SEQUENCE LISTING

<110>   Anthony Peter Davenport, Robert Charles Glen and Janet Julie Maguire

<120>   COMPOUNDS FOR USE AS APELIN RECEPTOR ANTAGONISTS 

<130>   P072818GB

<160>   Number of SEQ ID NOs: 17

<210>   SEQ ID NO: 1 
<211>   13
<212>   PRT
<213>   UNKNOWN	

<220>	Xaa
<221>   PYRROLIDONE CARBOXYLIC ACID
<222>   1
<223>   N-terminal glutamate which has formed an internal cyclic lactam

<400>   1
Xaa Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              

<210>   SEQ ID NO:2
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Cys
<221>   DISULFID
<222>   1
<223>   FROM 1 TO 6

<220>	Cys	
<221>   DISULFID
<222>   9
<223>   FROM 9 TO 14

<220>	Cys
<221>   DISULFID 
<222>   6
<223>   FROM 1 TO 6

<220>	Cys
<221>   DISULFID 
<222>   14
<223>   FROM 9 TO 14

<400>   2
Cys Arg Pro Arg Leu Cys Lys His Cys Arg Pro Arg Leu Cys 
1               5                   10                  

<210>   SEQ ID NO: 3
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<400>   3
Cys Arg Pro Arg Leu Cys His Lys Cys Arg Pro Arg Leu Cys 
1               5                   10                  

<210>   SEQ ID NO: 4
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<400>   4
Cys Arg Pro Arg Leu Cys Lys His Cys Arg Pro Arg Leu Cys 
1               5                   10                  

<210>   SEQ ID NO: 5
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Xaa
<221>   Nle 
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine 

<220>	Xaa
<221>   (3,4,5-trifluoro-)F
<222>   14
<223>   3,4,5-trifluorophenyl-L-alanine

<400>   5
Cys Arg Pro Arg Xaa Cys Lys His Cys Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 6
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine 

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine 

<220>	Xaa
<221>   (3,4,5-trifluoro-)F
<222>   14
<223>   3,4,5-trifluorophenyl-L-alanine

<400>   6
Gln Arg Pro Arg Xaa Cys Lys His Cys Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 7
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Xaa
<221>   PYRROLIDONE CARBOXYLIC ACID
<222>   1
<223>   N-terminal glutamate which has formed an internal cyclic lactam	

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<220>	Xaa
<221>   (3,4,5-trifluoro-)F
<222>   14
<223>   3,4,5-trifluorophenyl-L-alanine

<400>   7
Xaa Arg Pro Arg Xaa Cys Lys His Cys Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 8
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine 

<220>	Xaa
<221>   Abu
<222>   6
<223>   (S)-2-Aminobutyric acid 

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine 
	
<220>	Xaa
<221>   3,4,5-trifluoro-)F
<222>   14
<223>   3,4,5-trifluorophenyl-L-alanine

<400>   8
Cys Arg Pro Arg Xaa Xaa Lys His Cys Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 9
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Abu
<222>   9
<223>   (S)-2-Aminobutyric acid 

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<220>	Xaa
<221>   (3,4,5-TRIFLUORO-)F
<222>   14
<223>   3,4,5-trifluorophenyl-L-alanine

<400>   9
Cys Arg Pro Arg Xaa Cys Lys His Xaa Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 10
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Cys
<221>   LIPID 
<222>   1
<223>   MYRISTATE

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<220>	Xaa
<221>   (3,4,5-TRIFLUORO-)F
<222>   14
<223>   3,4,5-trifluorophenyl-L-alanine

<400>   10
Cys Arg Pro Arg Xaa Cys Lys His Cys Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 11
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Xaa
<221>   PYRROLIDONE CARBOXYLIC ACID
<222>   1
<223>   

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Abu
<222>   6
<223>   (S)-2-Aminobutyric acid

<220>	Xaa
<221>   Abu
<222>   9
<223>   (S)-2-Aminobutyric acid

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<220>	Xaa
<221>   (3,4,5-TRIFLUORO-)F
<222>   14
<223>   3,4,5-trifluorophenyl-L-alanine

<400>   11
Xaa Arg Pro Arg Xaa Xaa Lys His Xaa Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 12
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 
	
<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<400>   12
Cys Arg Pro Arg Xaa Cys His Lys Cys Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 13
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>
<221>   Aib
<222>   9
<223>   2-Aminobutyric acid

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<220>	Xaa
<221>   (3,4,5-TRIFLUORO-)F
<222>   14
<223>   3,4,5-trifluorophenyl-L-alanine

<400>   13
Ala Arg Pro Arg Xaa Cys Lys His Xaa Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 14
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Ala
<221>   ACETYLATION 
<222>   1
<223>   N-terminal

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Abu
<222>   9
<223>   2-Aminobutyric acid 

<220>	Xaa
<221>   Aib
<222>   11
<223>   (S)-2-Aminobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<400>   14
Ala Arg Pro Arg Xaa Cys Lys His Xaa Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 15
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Abu
<222>   6
<223>   (S)-2-Aminobutyric acid

<220>	Xaa
<221>   Abu
<222>   9
<223>   (S)-2-Aminobutyric acid

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<400>   15
Ala Arg Pro Arg Xaa Xaa Lys His Xaa Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 16
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Ala
<221>   LIPID
<222>   1
<223>   MYRISTATE 

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Abu
<222>   6
<223>   (S)-2-Aminobutyric acid

<220>	Xaa
<221>   Abu
<222>   9
<223>   (S)-2-Aminobutyric acid

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<400>   16
Ala Arg Pro Arg Xaa Xaa Lys His Xaa Arg Xaa Arg Xaa Xaa 
1               5                   10                  

<210>   SEQ ID NO: 17
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   ARTIFICIAL SEQUENCE

<220>	Ala
<221>   LIPID
<222>   1
<223>   MYRISTATE 

<220>	Xaa
<221>   Nle
<222>   5
<223>   Norleucine

<220>	Xaa
<221>   Abu
<222>   6
<223>   (S)-2-Aminobutyric acid

<220>	Xaa
<221>   Abu
<222>   9
<223>   (S)-2-Aminobutyric acid

<220>	Xaa
<221>   Aib
<222>   11
<223>   2-Aminoisobutyric acid 

<220>	Xaa
<221>   Nle
<222>   13
<223>   Norleucine

<220>	Xaa
<221>   (3,4,5-TRIFLUORO-)F
<222>   14
<223>   3,4,5-trifluorophenyl-L-alanine

<400>   17
Ala Arg Pro Arg Xaa Xaa His Lys Xaa Arg Xaa Arg Xaa Xaa 
1               5                   10                  

