                         SEQUENCE LISTING

<110>  BicycleTx Limited
 
<120>  HETEROTANDEM BICYCLIC PEPTIDE COMPLEXES

<130>  BIC-C-P2349PCT

<150>  1805492.4
<151>  2018-04-04

<150>  1820981.7
<151>  2018-12-21

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is Nle

<400>  1

Cys Ile Glu Glu Gly Gln Tyr Cys Phe Ala Asp Pro Tyr Xaa Cys 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is HyP

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is HArg

<400>  2

Cys Xaa Leu Val Asn Pro Leu Cys Leu His Pro Asp Trp Xaa Cys 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is tBuAla

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is Nle

<400>  3

Cys Xaa Pro Glu Ala Pro Tyr Cys Phe Ala Asp Pro Tyr Xaa Cys 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is Nle

<400>  4

Cys Ile Glu Glu Gly Gln Tyr Cys Phe Ala Asp Pro Tyr Xaa Cys 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is tBuAla

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is Nle

<400>  5

Cys Xaa Pro Lys Ala Pro Tyr Cys Phe Ala Asp Pro Tyr Xaa Cys 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is tBuAla

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is Nle

<400>  6

Cys Xaa Pro Glu Lys Pro Tyr Cys Phe Ala Asp Pro Tyr Xaa Cys 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is tBuAla

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is K(PYA)

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is Nle

<400>  7

Cys Xaa Pro Xaa Ala Pro Tyr Cys Phe Ala Asp Pro Tyr Xaa Cys 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is tBuAla

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is D-Lys(PYA)

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is Nle

<400>  8

Cys Xaa Pro Glu Xaa Pro Tyr Cys Phe Ala Asp Pro Tyr Xaa Cys 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is D-Lys(PYA)

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is Nle

<400>  9

Cys Ile Glu Glu Xaa Gln Tyr Cys Phe Ala Asp Pro Tyr Xaa Cys 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is K(PYA)

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is dNle

<400>  10

Cys Ile Glu Glu Xaa Gln Tyr Cys Phe Ala Asp Pro Tyr Xaa Cys 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is HArg

<400>  11

Cys Leu Trp Asp Pro Thr Pro Cys Ala Asn Leu His Leu Xaa Cys 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is HArg

<400>  12

Cys Xaa Asp Trp Cys His Trp Thr Phe Ser His Gly His Pro Cys 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  13

Cys Ser Ala Gly Trp Leu Thr Met Cys Gln Lys Leu His Leu Cys 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa is K(PYA)

<400>  14

Cys Ser Ala Gly Trp Leu Thr Met Cys Gln Xaa Leu His Leu Cys 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is 1Nal

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is HArg

<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa is HyP

<400>  15

Cys Pro Xaa Asp Cys Met Xaa Asp Trp Ser Thr Pro Xaa Trp Cys 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is 1Nal

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is HArg

<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa is HyP

<400>  16

Cys Pro Xaa Asp Cys Met Xaa Asp Trp Ser Thr Pro Xaa Trp Cys 
1               5                   10                  15  


<210>  17
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is 1Nal

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is (Sar10-(B-Ala))

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is HArg

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is HyP

<400>  17

Cys Pro Xaa Lys Xaa Cys Met Xaa Asp Trp Ser Thr Pro Xaa Trp Cys 
1               5                   10                  15      


<210>  18
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is HArg

<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa is HyP

<400>  18

Cys Pro Phe Gly Cys Met Xaa Asp Trp Ser Thr Pro Xaa Trp Cys 
1               5                   10                  15  


