                         SEQUENCE LISTING

<110>  Helmholtz-Zentrum Muenchen
 
<120>  Larval preparation of Heligmosomoides polygyrus bakeri as well as
        methods of making it and uses thereof

<130>  HEL16328PCT

<150>  EP 18000325.3
<151>  2018-04-05

<150>  EP 18165899.8
<151>  2018-04-05

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  537
<212>  PRT
<213>  Heligmosomoides polygyrus bakeri


<220>
<221>  MISC_FEATURE
<222>  (1)..(537)
<223>  Glutamate dehydrogenase; UniProtKB Accession Number: A0A183FP08

<400>  1

Met Leu Ser Thr Leu Ala Arg Thr Ser Gly Arg Leu Ile Phe Arg Arg 
1               5                   10                  15      


Ala Leu Ser Ser Ala Gln Met Asp Ala His Ala Gln Val Ile Asp Asp 
            20                  25                  30          


Leu Lys Pro Met Glu Glu Gln Ser Asn Pro Ser Phe Phe Lys Met Val 
        35                  40                  45              


Asp Tyr Tyr Phe Asp Lys Gly Ala Thr Val Ile Glu Pro Lys Leu Val 
    50                  55                  60                  


Glu Glu Met Lys Ser Asn Ser Met Ser Val Met Asp Lys Lys Asn Leu 
65                  70                  75                  80  


Val Ser Gly Ile Leu Lys Ala Ile Lys Pro Val Asn Lys Val Leu Tyr 
                85                  90                  95      


Ile Thr Phe Pro Ile Arg Arg Asp Asn Gly Glu Phe Glu Val Val Glu 
            100                 105                 110         


Ala Trp Arg Ala Gln His Ser Glu His Arg Thr Pro Thr Lys Gly Gly 
        115                 120                 125             


Ile Arg Tyr Ser Leu Asp Val Cys Glu Asp Glu Val Lys Ala Leu Ser 
    130                 135                 140                 


Ala Leu Met Thr Tyr Lys Cys Ala Ala Val Asp Val Pro Phe Gly Gly 
145                 150                 155                 160 


Ala Lys Gly Gly Val Lys Ile Asp Pro Lys Met Tyr Thr Asp Tyr Glu 
                165                 170                 175     


Ile Glu Lys Ile Thr Arg Arg Ile Ala Ile Glu Phe Ala Lys Lys Gly 
            180                 185                 190         


Phe Leu Gly Pro Gly Val Asp Val Pro Ala Pro Asp Met Gly Thr Gly 
        195                 200                 205             


Glu Arg Glu Met Gly Trp Ile Ala Asp Thr Tyr Ala Gln Thr Ile Gly 
    210                 215                 220                 


His Leu Asp Arg Asp Ala Ser Ala Cys Ile Thr Gly Lys Pro Ile Val 
225                 230                 235                 240 


Ala Gly Gly Ile His Gly Arg Val Ser Ala Thr Gly Arg Gly Val Trp 
                245                 250                 255     


Lys Gly Leu Glu Val Phe Ala Lys Glu Pro Glu Tyr Met Glu Lys Ile 
            260                 265                 270         


Gly Leu Thr Pro Gly Leu Pro Gly Lys Thr Val Ile Ile Gln Gly Phe 
        275                 280                 285             


Gly Asn Val Gly Leu His Thr Met Arg Tyr Leu His Arg Ala Gly Ser 
    290                 295                 300                 


Lys Val Val Gly Ile Gln Glu Trp Asp Cys Ala Ile His Asn Pro Ala 
305                 310                 315                 320 


Gly Ile His Pro Lys Glu Leu Glu Asp Trp Arg Asp Gln Thr Gly Ser 
                325                 330                 335     


Ile Lys Asn Phe Pro Gly Ala Lys Asn Phe Glu Pro Phe Gly Asp Leu 
            340                 345                 350         


Ile Tyr Glu Ala Cys Asp Ile Leu Val Pro Ala Ala Cys Glu Lys Ala 
        355                 360                 365             


Ile His Lys Glu Asn Ala Gly Arg Ile Gln Ala Lys Ile Ile Ala Glu 
    370                 375                 380                 


Ala Ala Asn Gly Pro Thr Thr Pro Ala Ala Asp Lys Ile Leu Leu Glu 
385                 390                 395                 400 


Arg Gly Asn Cys Leu Ile Ile Pro Asp Met Tyr Val Asn Ser Gly Gly 
                405                 410                 415     


Val Thr Val Ser Tyr Phe Glu Trp Leu Lys Asn Leu Asn His Val Ser 
            420                 425                 430         


Tyr Gly Arg Leu Ser Phe Lys Tyr Glu Glu Asp Ala Asn Leu Met Leu 
        435                 440                 445             


Leu Gln Ser Val Gln Asp Ser Leu Glu Lys Ala Ile Gly Lys Glu Ala 
    450                 455                 460                 


Pro Val Arg Pro Asn Ala Gln Phe Ala Ala Lys Ile Ala Gly Ala Ser 
465                 470                 475                 480 


Glu Lys Asp Ile Val His Ser Gly Leu Glu Tyr Thr Met Ala Arg Ser 
                485                 490                 495     


Gly Glu Ala Ile Ile Arg Thr Ala Arg Lys Tyr Asn Leu Gly Leu Asp 
            500                 505                 510         


Met Arg Thr Ala Ala Tyr Ala Asn Ser Ile Glu Lys Val Tyr Asn Thr 
        515                 520                 525             


Tyr Arg Thr Ala Gly Phe Thr Phe Thr 
    530                 535         


<210>  2
<211>  152
<212>  PRT
<213>  Heligmosomoides polygyrus bakeri


<220>
<221>  MISC_FEATURE
<222>  (1)..(152)
<223>  Ferritin; UniProtKB Accession Number: A0A183FLG6

<400>  2

Leu Val Asn Ile Glu Leu Tyr Ala Ser Tyr Val Tyr Leu Ser Met Ser 
1               5                   10                  15      


Ala Tyr Phe Asp Arg Asp Asp Val Ala Leu Pro Asn Val Ser Lys Trp 
            20                  25                  30          


Leu Arg Lys Gln Ser Asp Glu Glu Arg Glu His Ala Ile Lys Leu Ile 
        35                  40                  45              


Asn Phe Gln Asn Leu Arg Gly Gly Arg Val Val Phe Gln Ala Val Asn 
    50                  55                  60                  


Lys Pro Glu Lys Asp Glu Trp Gly Ser Ala Leu Glu Ala Phe Gln Ala 
65                  70                  75                  80  


Ala Leu Ala Leu Glu Lys Phe Asn Asn Gln Ala Leu Leu Asp Leu His 
                85                  90                  95      


Ala Lys Ala Ala Ala Ala Asn Asp Ala Gln Met Ser Asp Phe Ile Glu 
            100                 105                 110         


Ser Thr Tyr Leu Gly Glu Gln Val Glu Ser Ile Ser Glu Ile Ala Lys 
        115                 120                 125             


Met Val Thr Asn Leu Lys Arg Leu Gly Pro Gly Met Gly Glu Tyr Val 
    130                 135                 140                 


Phe Asp Lys Glu Gln Phe Asp Ser 
145                 150         


<210>  3
<211>  408
<212>  PRT
<213>  Heligmosomoides polygyrus bakeri


<220>
<221>  MISC_FEATURE
<222>  (1)..(408)
<223>  Aspartate aminotransferase; UniProtKB Accession Number: 
       A0A183FI07

<400>  3

Met Ser Phe Phe Glu Gly Ile Ala Val Ala Pro Pro Ile Glu Val Phe 
1               5                   10                  15      


Phe Met Asn Lys Met Tyr Met Asp Glu Lys Asp Pro Asn Lys Val Asn 
            20                  25                  30          


Leu Thr Val Gly Ala Tyr Arg Thr Glu Glu Gly Lys Pro Trp Val Leu 
        35                  40                  45              


Pro Val Val Arg Glu Ala Glu Lys Ala Ile Ala Ala Asp Glu Thr Leu 
    50                  55                  60                  


Asn His Glu Tyr Leu Pro Val Leu Gly Met Glu Ala Phe Thr Glu Val 
65                  70                  75                  80  


Ala Cys Lys Leu Val Leu Gly Glu Gln Ser Pro Ala Ile Thr Gly Gly 
                85                  90                  95      


Arg Tyr Phe Gly Thr Gln Cys Leu Ser Gly Thr Gly Ser Leu Arg Ala 
            100                 105                 110         


Gly Ala Glu Phe Leu Ala Arg Val Leu Gly Tyr Lys Thr Val Leu Leu 
        115                 120                 125             


Ser Asn Pro Thr Trp Gly Asn His Lys Leu Val Phe His Asn Ala Gly 
    130                 135                 140                 


Phe Thr Asp Val Gly Ser Tyr Thr Tyr Trp Asp Ala Thr Asn Arg Lys 
145                 150                 155                 160 


Val Asp Met Gln Lys Met Leu Tyr Asp Leu Glu Glu Ala Pro Glu Lys 
                165                 170                 175     


Ser Val Ile Val Leu His Gly Cys Ala His Asn Pro Thr Gly Met Asp 
            180                 185                 190         


Pro Thr Gln Asp Gln Trp Arg Gln Ile Cys Glu Val Ile Lys Arg Arg 
        195                 200                 205             


His Leu Phe Pro Phe Phe Asp Ile Ala Tyr Gln Gly Phe Ala Ser Gly 
    210                 215                 220                 


Asn Pro Asp Ala Asp Ala Trp Ser Ile Arg Tyr Phe Val Glu Gln Gly 
225                 230                 235                 240 


Leu Glu Met Phe Ile Ala Gln Ser Phe Ala Lys Asn Phe Gly Leu Tyr 
                245                 250                 255     


Asn Glu Arg Val Gly Asn Leu Cys Ala Val Val Lys Asp Pro Ser Val 
            260                 265                 270         


Leu Pro Gly Tyr Lys Ser Gln Met Ser Leu Ile Ile Arg Ala Asn Trp 
        275                 280                 285             


Ser Asn Pro Pro Val His Gly Ala Arg Ile Val His Lys Val Leu Ser 
    290                 295                 300                 


Thr Pro Ala Leu Arg Ala Thr Trp Asp Gln Asn Ile Gln Thr Met Ser 
305                 310                 315                 320 


Ser Arg Ile Lys Gln Met Arg Ser Leu Leu Gln Ser His Leu Glu Lys 
                325                 330                 335     


Leu Gly Thr Pro Gly Ser Trp Thr His Ile Thr Gln Gln Ile Gly Met 
            340                 345                 350         


Phe Ser Phe Thr Gly Leu Thr Pro Ala Gln Val Asp His Leu Val Lys 
        355                 360                 365             


Lys His Lys Ile Phe Leu Leu Lys Asn Gly Arg Ile Ser Val Cys Gly 
    370                 375                 380                 


Leu Asn Thr Lys Asn Val Glu Tyr Val Ala Lys Ala Ile Asp Asp Ala 
385                 390                 395                 400 


Val Arg Asn Val Pro Ser Asn Leu 
                405             


<210>  4
<211>  450
<212>  PRT
<213>  Heligmosomoides polygyrus bakeri


<220>
<221>  MISC_FEATURE
<222>  (1)..(450)
<223>  Tubulin alpha chain; UniProtKB Accession Number: A0A183GTY4

<400>  4

Met Val Gly Tyr Phe Arg Glu Val Ile Ser Ile His Val Gly Gln Ala 
1               5                   10                  15      


Gly Val Gln Ile Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His 
            20                  25                  30          


Gly Ile Gln Pro Asp Gly Ile Met Pro Thr Lys Asn Val Asn Glu Ser 
        35                  40                  45              


Phe Thr Thr Phe Phe Ser Glu Thr Gly Asn Ser Arg Phe Val Pro Arg 
    50                  55                  60                  


Ala Ile Met Val Asp Leu Glu Pro Thr Val Val Asp Glu Ile Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Lys Gln Leu Phe His Pro Glu Gln Met Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Val Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Thr Arg Arg Leu Ala Asp Asn 
        115                 120                 125             


Cys Ser Gly Leu Gln Gly Phe Leu Ile Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Val Glu Arg Pro Ser Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Ile Ile Ser Gln Val Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Glu Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ser Pro Leu Ile Ser Ala Glu Lys Ala Tyr His Glu Ala Leu Ser Val 
        275                 280                 285             


Gly Asp Ile Thr Asn Met Cys Phe Glu Pro Cys Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg Asn Gly Lys Tyr Met Ala Val Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Gln Ala Ile Ser Ala Ile Lys 
                325                 330                 335     


Ala Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Ile 
        355                 360                 365             


Ala Lys Val Pro Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Leu Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Ser Asp Ser Asn Glu Glu Gly Tyr Glu Glu Gly Glu 
        435                 440                 445             


Glu Tyr 
    450 


<210>  5
<211>  123
<212>  PRT
<213>  Heligmosomoides polygyrus bakeri


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  Histone H2B; UniProtKB Accession Number: A0A183FWH9

<400>  5

Met Pro Pro Lys Pro Ser Ala Lys Gly Ala Lys Lys Ala Ala Lys Ser 
1               5                   10                  15      


Gln Lys Ala Ala Arg Thr Gly Asp Lys Lys Lys Arg His Arg Arg Lys 
            20                  25                  30          


Glu Ser Tyr Ser Val Tyr Ile Tyr Arg Val Leu Lys Gln Val His Pro 
        35                  40                  45              


Asp Thr Gly Val Ser Ser Lys Ala Met Ser Ile Met Asn Ser Phe Val 
    50                  55                  60                  


Asn Asp Val Phe Glu Arg Ile Ala Ala Glu Ala Ser Arg Leu Ala His 
65                  70                  75                  80  


Tyr Asn Lys Arg Ser Thr Ile Ser Ser Arg Glu Ile Gln Thr Ala Val 
                85                  90                  95      


Arg Leu Ile Leu Pro Gly Glu Leu Ala Lys His Ala Val Ser Glu Gly 
            100                 105                 110         


Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120             


<210>  6
<211>  13
<212>  PRT
<213>  Heligmosomoides polygyrus bakeri

<400>  6

Ala Gln His Ser Glu His Arg Thr Pro Thr Lys Gly Gly 
1               5                   10              


<210>  7
<211>  12
<212>  PRT
<213>  Heligmosomoides polygyrus bakeri

<400>  7

Leu Lys Pro Met Glu Glu Gln Ser Asn Pro Ser Phe 
1               5                   10          


