                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche Ltd
 
<120>  Diagnostic assays to detect tumor antigens in cancer patients

<130>  P34755

<160>  132   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G CDR H1 Kabat

<400>  1

Arg Tyr Trp Met Asn 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G CDR H2

<400>  2

Glu Ile Thr Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G CDR H3 Kabat

<400>  3

Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Ser 
1               5                   10  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G CDR L1 Kabat

<400>  4

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G CDR L2 Kabat

<400>  5

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G CDR L3 Kabat

<400>  6

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  7
<211>  433
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G-ds-scFv-CD28ATD-CD28CSD-CD3zSSD fusion

<400>  7

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Thr Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ile Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr 
    130                 135                 140                 


Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr 
145                 150                 155                 160 


Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp 
                165                 170                 175     


Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr 
            180                 185                 190         


Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile 
        195                 200                 205             


Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu 
    210                 215                 220                 


Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly 
225                 230                 235                 240 


Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Phe Trp Val 
                245                 250                 255     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            260                 265                 270         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        275                 280                 285             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    290                 295                 300                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
305                 310                 315                 320 


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                325                 330                 335     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            340                 345                 350         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        355                 360                 365             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    370                 375                 380                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
385                 390                 395                 400 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                405                 410                 415     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            420                 425                 430         


Arg 
    


<210>  8
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G-ds VH

<400>  8

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Thr Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ile Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  9
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G-ds VL

<400>  9

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  10
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G-ds-scFv

<400>  10

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Thr Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ile Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr 
    130                 135                 140                 


Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr 
145                 150                 155                 160 


Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp 
                165                 170                 175     


Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr 
            180                 185                 190         


Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile 
        195                 200                 205             


Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu 
    210                 215                 220                 


Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly 
225                 230                 235                 240 


Cys Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  11
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28ATD

<400>  11

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  12
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28CSD

<400>  12

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  13
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD3zSSD

<400>  13

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  14
<211>  180
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28ATD-CD28CSD-CD3zSSD

<400>  14

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
65                  70                  75                  80  


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                85                  90                  95      


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            100                 105                 110         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        115                 120                 125             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    130                 135                 140                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
145                 150                 155                 160 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                165                 170                 175     


Leu Pro Pro Arg 
            180 


<210>  15
<211>  238
<212>  PRT
<213>  Artificial sequence

<220>
<223>  eGFP

<400>  15

Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  16
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  (G4S)4 linker

<400>  16

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  17
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G4S linker

<400>  17

Gly Gly Gly Gly Ser 
1               5   


<210>  18
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T2A linker

<400>  18

Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  19
<211>  1356
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-P329G-ds-scFv-CD28ATD-CD28CSD-CD3zSSD fusion

<400>  19
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgaagctgc tggagagcgg cggcggcctg gtgcagcccg gcggcagcct gaagctgagc      120

tgcgccgcca gcggcttcga cttcagcagg tactggatga actgggtgag gcaggccccc      180

ggcaagtgtc tggagtggat cggcgagatc acccccgaca gcagcaccat caactacacc      240

cccagcctga aggacaagtt catcatcagc agggacaacg ccaagaacac cctgtacctg      300

cagatgatca aggtgaggag cgaggacacc gccctgtact actgcgtgag gccctacgac      360

tacggcgcct ggttcgccag ctggggccag ggcaccctgg tgaccgtgag cgccggaggg      420

ggcggaagtg gtggcggggg aagcggcggg ggtggcagcg gagggggcgg atctcaggcc      480

gtggtgaccc aggagagcgc cctgaccacc agccccggcg agaccgtgac cctgacctgc      540

aggagcagca ccggcgccgt gaccaccagc aactacgcca actgggtgca ggagaagccc      600

gaccacctgt tcaccggcct gatcggcggc accaacaaga gggcccccgg cgtgcccgcc      660

aggttcagcg gcagcctgat cggcgacaag gccgccctga ccatcaccgg cgcccagacc      720

gaggacgagg ccatctactt ctgcgccctg tggtacagca accactgggt gttcggctgt      780

ggcaccaagc tgaccgtgct gggagggggc ggatccttct gggtgctggt ggtggtgggc      840

ggcgtgctgg cctgctacag cctgctggtg accgtggcct tcatcatctt ctgggtgagg      900

agcaagagga gcaggctgct gcacagcgac tacatgaaca tgacccccag gaggcccggc      960

cccaccagga agcactacca gccctacgcc ccccccaggg acttcgccgc ctacaggagc     1020

agggtgaagt tcagcaggag cgccgacgcc cccgcctacc agcagggcca gaaccagctg     1080

tataacgagc tgaacctggg caggagggag gagtacgacg tgctggacaa gaggaggggc     1140

agggaccccg agatgggcgg caagcccagg aggaagaacc cccaggaggg cctgtataac     1200

gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagagg     1260

aggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggacacc     1320

tacgacgccc tgcacatgca ggccctgccc cccagg                               1356


<210>  20
<211>  357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-P329G-ds VH

<400>  20
gaggtgaagc tgctggagag cggcggcggc ctggtgcagc ccggcggcag cctgaagctg       60

agctgcgccg ccagcggctt cgacttcagc aggtactgga tgaactgggt gaggcaggcc      120

cccggcaagt gtctggagtg gatcggcgag atcacccccg acagcagcac catcaactac      180

acccccagcc tgaaggacaa gttcatcatc agcagggaca acgccaagaa caccctgtac      240

ctgcagatga tcaaggtgag gagcgaggac accgccctgt actactgcgt gaggccctac      300

gactacggcg cctggttcgc cagctggggc cagggcaccc tggtgaccgt gagcgcc         357


<210>  21
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-P329G-ds VL

<400>  21
caggccgtgg tgacccagga gagcgccctg accaccagcc ccggcgagac cgtgaccctg       60

acctgcagga gcagcaccgg cgccgtgacc accagcaact acgccaactg ggtgcaggag      120

aagcccgacc acctgttcac cggcctgatc ggcggcacca acaagagggc ccccggcgtg      180

cccgccaggt tcagcggcag cctgatcggc gacaaggccg ccctgaccat caccggcgcc      240

cagaccgagg acgaggccat ctacttctgc gccctgtggt acagcaacca ctgggtgttc      300

ggctgtggca ccaagctgac cgtgctg                                          327


<210>  22
<211>  801
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-P329G-ds-scFv

<400>  22
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgaagctgc tggagagcgg cggcggcctg gtgcagcccg gcggcagcct gaagctgagc      120

tgcgccgcca gcggcttcga cttcagcagg tactggatga actgggtgag gcaggccccc      180

ggcaagtgtc tggagtggat cggcgagatc acccccgaca gcagcaccat caactacacc      240

cccagcctga aggacaagtt catcatcagc agggacaacg ccaagaacac cctgtacctg      300

cagatgatca aggtgaggag cgaggacacc gccctgtact actgcgtgag gccctacgac      360

tacggcgcct ggttcgccag ctggggccag ggcaccctgg tgaccgtgag cgccggaggg      420

ggcggaagtg gtggcggggg aagcggcggg ggtggcagcg gagggggcgg atctcaggcc      480

gtggtgaccc aggagagcgc cctgaccacc agccccggcg agaccgtgac cctgacctgc      540

aggagcagca ccggcgccgt gaccaccagc aactacgcca actgggtgca ggagaagccc      600

gaccacctgt tcaccggcct gatcggcggc accaacaaga gggcccccgg cgtgcccgcc      660

aggttcagcg gcagcctgat cggcgacaag gccgccctga ccatcaccgg cgcccagacc      720

gaggacgagg ccatctactt ctgcgccctg tggtacagca accactgggt gttcggctgt      780

ggcaccaagc tgaccgtgct g                                                801


<210>  23
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD28ATD

<400>  23
ttctgggtgc tggtggtggt gggcggcgtg ctggcctgct acagcctgct ggtgaccgtg       60

gccttcatca tcttctgggt g                                                 81


<210>  24
<211>  123
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD28CSD

<400>  24
aggagcaaga ggagcaggct gctgcacagc gactacatga acatgacccc caggaggccc       60

ggccccacca ggaagcacta ccagccctac gcccccccca gggacttcgc cgcctacagg      120

agc                                                                    123


<210>  25
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD3zSSD

<400>  25
agggtgaagt tcagcaggag cgccgacgcc cccgcctacc agcagggcca gaaccagctg       60

tataacgagc tgaacctggg caggagggag gagtacgacg tgctggacaa gaggaggggc      120

agggaccccg agatgggcgg caagcccagg aggaagaacc cccaggaggg cctgtataac      180

gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagagg      240

aggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggacacc      300

tacgacgccc tgcacatgca ggccctgccc cccagg                                336


<210>  26
<211>  540
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD28ATD-CD28CSD-CD3zSSD

<400>  26
ttctgggtgc tggtggtggt gggcggcgtg ctggcctgct acagcctgct ggtgaccgtg       60

gccttcatca tcttctgggt gaggagcaag aggagcaggc tgctgcacag cgactacatg      120

aacatgaccc ccaggaggcc cggccccacc aggaagcact accagcccta cgcccccccc      180

agggacttcg ccgcctacag gagcagggtg aagttcagca ggagcgccga cgcccccgcc      240

taccagcagg gccagaacca gctgtataac gagctgaacc tgggcaggag ggaggagtac      300

gacgtgctgg acaagaggag gggcagggac cccgagatgg gcggcaagcc caggaggaag      360

aacccccagg agggcctgta taacgagctg cagaaggaca agatggccga ggcctacagc      420

gagatcggca tgaagggcga gaggaggagg ggcaagggcc acgacggcct gtaccagggc      480

ctgagcaccg ccaccaagga cacctacgac gccctgcaca tgcaggccct gccccccagg      540


<210>  27
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  T2A element

<400>  27
tccggagagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct       60

agg                                                                     63


<210>  28
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  eGFP

<400>  28
gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc       60

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc      120

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc      180

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag      240

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc      300

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg      360

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag      420

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc      480

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac      540

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac      600

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg      660

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtga         717


<210>  29
<211>  2136
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-P329G-ds-scFv-CD28ATD-CD28CSD-CD3zSSD-eGFP fusion

<400>  29
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgaagctgc tggagagcgg cggcggcctg gtgcagcccg gcggcagcct gaagctgagc      120

tgcgccgcca gcggcttcga cttcagcagg tactggatga actgggtgag gcaggccccc      180

ggcaagtgtc tggagtggat cggcgagatc acccccgaca gcagcaccat caactacacc      240

cccagcctga aggacaagtt catcatcagc agggacaacg ccaagaacac cctgtacctg      300

cagatgatca aggtgaggag cgaggacacc gccctgtact actgcgtgag gccctacgac      360

tacggcgcct ggttcgccag ctggggccag ggcaccctgg tgaccgtgag cgccggaggg      420

ggcggaagtg gtggcggggg aagcggcggg ggtggcagcg gagggggcgg atctcaggcc      480

gtggtgaccc aggagagcgc cctgaccacc agccccggcg agaccgtgac cctgacctgc      540

aggagcagca ccggcgccgt gaccaccagc aactacgcca actgggtgca ggagaagccc      600

gaccacctgt tcaccggcct gatcggcggc accaacaaga gggcccccgg cgtgcccgcc      660

aggttcagcg gcagcctgat cggcgacaag gccgccctga ccatcaccgg cgcccagacc      720

gaggacgagg ccatctactt ctgcgccctg tggtacagca accactgggt gttcggctgt      780

ggcaccaagc tgaccgtgct gggagggggc ggatccttct gggtgctggt ggtggtgggc      840

ggcgtgctgg cctgctacag cctgctggtg accgtggcct tcatcatctt ctgggtgagg      900

agcaagagga gcaggctgct gcacagcgac tacatgaaca tgacccccag gaggcccggc      960

cccaccagga agcactacca gccctacgcc ccccccaggg acttcgccgc ctacaggagc     1020

agggtgaagt tcagcaggag cgccgacgcc cccgcctacc agcagggcca gaaccagctg     1080

tataacgagc tgaacctggg caggagggag gagtacgacg tgctggacaa gaggaggggc     1140

agggaccccg agatgggcgg caagcccagg aggaagaacc cccaggaggg cctgtataac     1200

gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagagg     1260

aggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggacacc     1320

tacgacgccc tgcacatgca ggccctgccc cccaggtccg gagagggcag aggaagtctt     1380

ctaacatgcg gtgacgtgga ggagaatccc ggccctaggg tgagcaaggg cgaggagctg     1440

ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc     1500

agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc     1560

tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc     1620

gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc     1680

atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag     1740

acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc     1800

atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc     1860

cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc     1920

cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc     1980

atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg     2040

agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc     2100

gggatcactc tcggcatgga cgagctgtac aagtga                               2136


<210>  30
<211>  407
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G-Fab-heavy chain- CD28ATD-CD28CSD-CD3zSSD fusion

<400>  30

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Thr Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ile Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Gly 
    210                 215                 220                 


Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
225                 230                 235                 240 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
                245                 250                 255     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            260                 265                 270         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        275                 280                 285             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    290                 295                 300                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
305                 310                 315                 320 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                325                 330                 335     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            340                 345                 350         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        355                 360                 365             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    370                 375                 380                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
385                 390                 395                 400 


Met Gln Ala Leu Pro Pro Arg 
                405         


<210>  31
<211>  222
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G-Fab heavy chain

<400>  31

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Thr Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ile Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  32
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G-Fab light chain

<400>  32

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  33
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G VL

<400>  33

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  34
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CL

<400>  34

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  35
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-P329G VH

<400>  35

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Thr Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ile Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  36
<211>  103
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CH1

<400>  36

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys 
            100             


<210>  37
<211>  2645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-P329G-Fab-heavy chain- CD28ATD-CD28CSD-CD3zSSD fusion

<400>  37
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacgggtgt gcattcccag       60

gccgtggtga cccaggagag cgccctgacc accagccccg gcgagaccgt gaccctgacc      120

tgcaggagca gcaccggcgc cgtgaccacc agcaactacg ccaactgggt gcaggagaag      180

cccgaccacc tgttcaccgg cctgatcggc ggcaccaaca agagggcccc cggcgtgccc      240

gccaggttca gcggcagcct gatcggcgac aaggccgccc tgaccatcac cggcgcccag      300

accgaggacg aggccatcta cttctgcgcc ctgtggtaca gcaaccactg ggtgttcggc      360

ggtggcacca agctgaccgt gctgcgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttagga attccccgaa      720

gtaacttaga agctgtaaat caacgatcaa tagcaggtgt ggcacaccag tcataccttg      780

atcaagcact tctgtttccc cggactgagt atcaataggc tgctcgcgcg gctgaaggag      840

aaaacgttcg ttacccgacc aactacttcg agaagcttag taccaccatg aacgaggcag      900

ggtgtttcgc tcagcacaac cccagtgtag atcaggctga tgagtcactg caacccccat      960

gggcgaccat ggcagtggct gcgttggcgg cctgcccatg gagaaatcca tgggacgctc     1020

taattctgac atggtgtgaa gtgcctattg agctaactgg tagtcctccg gcccctgatt     1080

gcggctaatc ctaactgcgg agcacatgct cacaaaccag tgggtggtgt gtcgtaacgg     1140

gcaactctgc agcggaaccg actactttgg gtgtccgtgt ttccttttat tcctatattg     1200

gctgcttatg gtgacaatca aaaagttgtt accatatagc tattggattg gccatccggt     1260

gtgcaacagg gcaactgttt acctatttat tggttttgta ccattatcac tgaagtctgt     1320

gatcactctc aaattcattt tgaccctcaa cacaatcaaa cgccaccatg ggatggagct     1380

gtatcatcct cttcttggta gcaacagcta ccggtgtgca ctccgaggtg aagctgctgg     1440

agagcggcgg cggcctggtg cagcccggcg gcagcctgaa gctgagctgc gccgccagcg     1500

gcttcgactt cagcaggtac tggatgaact gggtgaggca ggcccccggc aagggtctgg     1560

agtggatcgg cgagatcacc cccgacagca gcaccatcaa ctacaccccc agcctgaagg     1620

acaagttcat catcagcagg gacaacgcca agaacaccct gtacctgcag atgatcaagg     1680

tgaggagcga ggacaccgcc ctgtactact gcgtgaggcc ctacgactac ggcgcctggt     1740

tcgccagctg gggccagggc accctggtga ccgtgagcgc cgctagcacc aagggcccct     1800

ccgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcacagcc gctctgggct     1860

gcctggtcaa ggactacttc cccgagcccg tgaccgtgtc ctggaacagc ggagccctga     1920

cctccggcgt gcacaccttc cccgccgtgc tgcagagttc tggcctgtat agcctgagca     1980

gcgtggtcac cgtgccttct agcagcctgg gcacccagac ctacatctgc aacgtgaacc     2040

acaagcccag caacaccaag gtggacaaga aggtggagcc caagagctgc ggagggggcg     2100

gatccttctg ggtgctggtg gtggtgggcg gcgtgctggc ctgctacagc ctgctggtga     2160

ccgtggcctt catcatcttc tgggtgagga gcaagaggag caggctgctg cacagcgact     2220

acatgaacat gacccccagg aggcccggcc ccaccaggaa gcactaccag ccctacgccc     2280

cccccaggga cttcgccgcc tacaggagca gggtgaagtt cagcaggagc gccgacgccc     2340

ccgcctacca gcagggccag aaccagctgt ataacgagct gaacctgggc aggagggagg     2400

agtacgacgt gctggacaag aggaggggca gggaccccga gatgggcggc aagcccagga     2460

ggaagaaccc ccaggagggc ctgtataacg agctgcagaa ggacaagatg gccgaggcct     2520

acagcgagat cggcatgaag ggcgagagga ggaggggcaa gggccacgac ggcctgtacc     2580

agggcctgag caccgccacc aaggacacct acgacgccct gcacatgcag gccctgcccc     2640

ccagg                                                                 2645


<210>  38
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-P329G VL

<400>  38
caggccgtgg tgacccagga gagcgccctg accaccagcc ccggcgagac cgtgaccctg       60

acctgcagga gcagcaccgg cgccgtgacc accagcaact acgccaactg ggtgcaggag      120

aagcccgacc acctgttcac cggcctgatc ggcggcacca acaagagggc ccccggcgtg      180

cccgccaggt tcagcggcag cctgatcggc gacaaggccg ccctgaccat caccggcgcc      240

cagaccgagg acgaggccat ctacttctgc gccctgtggt acagcaacca ctgggtgttc      300

ggcggtggca ccaagctgac cgtgctg                                          327


<210>  39
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CL

<400>  39
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  40
<211>  357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-P329G VH

<400>  40
gaggtgaagc tgctggagag cggcggcggc ctggtgcagc ccggcggcag cctgaagctg       60

agctgcgccg ccagcggctt cgacttcagc aggtactgga tgaactgggt gaggcaggcc      120

cccggcaagg gtctggagtg gatcggcgag atcacccccg acagcagcac catcaactac      180

acccccagcc tgaaggacaa gttcatcatc agcagggaca acgccaagaa caccctgtac      240

ctgcagatga tcaaggtgag gagcgaggac accgccctgt actactgcgt gaggccctac      300

gactacggcg cctggttcgc cagctggggc cagggcaccc tggtgaccgt gagcgcc         357


<210>  41
<211>  309
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CH1

<400>  41
gctagcacca agggcccctc cgtgttcccc ctggccccca gcagcaagag caccagcggc       60

ggcacagccg ctctgggctg cctggtcaag gactacttcc ccgagcccgt gaccgtgtcc      120

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagttct      180

ggcctgtata gcctgagcag cgtggtcacc gtgccttcta gcagcctggg cacccagacc      240

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      300

aagagctgc                                                              309


<210>  42
<211>  647
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IRES EV71, internal ribosomal entry side

<400>  42
cccgaagtaa cttagaagct gtaaatcaac gatcaatagc aggtgtggca caccagtcat       60

accttgatca agcacttctg tttccccgga ctgagtatca ataggctgct cgcgcggctg      120

aaggagaaaa cgttcgttac ccgaccaact acttcgagaa gcttagtacc accatgaacg      180

aggcagggtg tttcgctcag cacaacccca gtgtagatca ggctgatgag tcactgcaac      240

ccccatgggc gaccatggca gtggctgcgt tggcggcctg cccatggaga aatccatggg      300

acgctctaat tctgacatgg tgtgaagtgc ctattgagct aactggtagt cctccggccc      360

ctgattgcgg ctaatcctaa ctgcggagca catgctcaca aaccagtggg tggtgtgtcg      420

taacgggcaa ctctgcagcg gaaccgacta ctttgggtgt ccgtgtttcc ttttattcct      480

atattggctg cttatggtga caatcaaaaa gttgttacca tatagctatt ggattggcca      540

tccggtgtgc aacagggcaa ctgtttacct atttattggt tttgtaccat tatcactgaa      600

gtctgtgatc actctcaaat tcattttgac cctcaacaca atcaaac                    647


<210>  43
<211>  3425
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-P329G-Fab-heavy chain- CD28ATD-CD28CSD-CD3zSSD-eGFP fusion

<400>  43
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacgggtgt gcattcccag       60

gccgtggtga cccaggagag cgccctgacc accagccccg gcgagaccgt gaccctgacc      120

tgcaggagca gcaccggcgc cgtgaccacc agcaactacg ccaactgggt gcaggagaag      180

cccgaccacc tgttcaccgg cctgatcggc ggcaccaaca agagggcccc cggcgtgccc      240

gccaggttca gcggcagcct gatcggcgac aaggccgccc tgaccatcac cggcgcccag      300

accgaggacg aggccatcta cttctgcgcc ctgtggtaca gcaaccactg ggtgttcggc      360

ggtggcacca agctgaccgt gctgcgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttagga attccccgaa      720

gtaacttaga agctgtaaat caacgatcaa tagcaggtgt ggcacaccag tcataccttg      780

atcaagcact tctgtttccc cggactgagt atcaataggc tgctcgcgcg gctgaaggag      840

aaaacgttcg ttacccgacc aactacttcg agaagcttag taccaccatg aacgaggcag      900

ggtgtttcgc tcagcacaac cccagtgtag atcaggctga tgagtcactg caacccccat      960

gggcgaccat ggcagtggct gcgttggcgg cctgcccatg gagaaatcca tgggacgctc     1020

taattctgac atggtgtgaa gtgcctattg agctaactgg tagtcctccg gcccctgatt     1080

gcggctaatc ctaactgcgg agcacatgct cacaaaccag tgggtggtgt gtcgtaacgg     1140

gcaactctgc agcggaaccg actactttgg gtgtccgtgt ttccttttat tcctatattg     1200

gctgcttatg gtgacaatca aaaagttgtt accatatagc tattggattg gccatccggt     1260

gtgcaacagg gcaactgttt acctatttat tggttttgta ccattatcac tgaagtctgt     1320

gatcactctc aaattcattt tgaccctcaa cacaatcaaa cgccaccatg ggatggagct     1380

gtatcatcct cttcttggta gcaacagcta ccggtgtgca ctccgaggtg aagctgctgg     1440

agagcggcgg cggcctggtg cagcccggcg gcagcctgaa gctgagctgc gccgccagcg     1500

gcttcgactt cagcaggtac tggatgaact gggtgaggca ggcccccggc aagggtctgg     1560

agtggatcgg cgagatcacc cccgacagca gcaccatcaa ctacaccccc agcctgaagg     1620

acaagttcat catcagcagg gacaacgcca agaacaccct gtacctgcag atgatcaagg     1680

tgaggagcga ggacaccgcc ctgtactact gcgtgaggcc ctacgactac ggcgcctggt     1740

tcgccagctg gggccagggc accctggtga ccgtgagcgc cgctagcacc aagggcccct     1800

ccgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcacagcc gctctgggct     1860

gcctggtcaa ggactacttc cccgagcccg tgaccgtgtc ctggaacagc ggagccctga     1920

cctccggcgt gcacaccttc cccgccgtgc tgcagagttc tggcctgtat agcctgagca     1980

gcgtggtcac cgtgccttct agcagcctgg gcacccagac ctacatctgc aacgtgaacc     2040

acaagcccag caacaccaag gtggacaaga aggtggagcc caagagctgc ggagggggcg     2100

gatccttctg ggtgctggtg gtggtgggcg gcgtgctggc ctgctacagc ctgctggtga     2160

ccgtggcctt catcatcttc tgggtgagga gcaagaggag caggctgctg cacagcgact     2220

acatgaacat gacccccagg aggcccggcc ccaccaggaa gcactaccag ccctacgccc     2280

cccccaggga cttcgccgcc tacaggagca gggtgaagtt cagcaggagc gccgacgccc     2340

ccgcctacca gcagggccag aaccagctgt ataacgagct gaacctgggc aggagggagg     2400

agtacgacgt gctggacaag aggaggggca gggaccccga gatgggcggc aagcccagga     2460

ggaagaaccc ccaggagggc ctgtataacg agctgcagaa ggacaagatg gccgaggcct     2520

acagcgagat cggcatgaag ggcgagagga ggaggggcaa gggccacgac ggcctgtacc     2580

agggcctgag caccgccacc aaggacacct acgacgccct gcacatgcag gccctgcccc     2640

ccaggtccgg agagggcaga ggaagtcttc taacatgcgg tgacgtggag gagaatcccg     2700

gccctagggt gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc     2760

tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca     2820

cctacggcaa gctgaccctg aagttcatct gcaccaccgg caagctgccc gtgccctggc     2880

ccaccctcgt gaccaccctg acctacggcg tgcagtgctt cagccgctac cccgaccaca     2940

tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca     3000

tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca     3060

ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg     3120

ggcacaagct ggagtacaac tacaacagcc acaacgtcta tatcatggcc gacaagcaga     3180

agaacggcat caaggtgaac ttcaagatcc gccacaacat cgaggacggc agcgtgcagc     3240

tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca     3300

accactacct gagcacccag tccgccctga gcaaagaccc caacgagaag cgcgatcaca     3360

tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac gagctgtaca     3420

agtga                                                                 3425


<210>  44
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA CDR H1 Kabat

<400>  44

Ser Tyr Gly Met Ser 
1               5   


<210>  45
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA CDR H2 Kabat

<400>  45

Ser Ser Gly Gly Ser Tyr 
1               5       


<210>  46
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA CDR H3 Kabat

<400>  46

Leu Gly Met Ile Thr Thr Gly Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  47
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA CDR L1 Kabat

<400>  47

Arg Ser Ser Gln Thr Ile Val His Ser Thr Gly His Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  48
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA CDR L2 Kabat

<400>  48

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  49
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA CDR L3 Kabat

<400>  49

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  50
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA-scFv-CD28ATD-CD28CSD-CD3zSSD fusion

<400>  50

Met Asn Phe Gly Leu Ser Leu Val Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Met Ile Thr Thr Gly Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
                165                 170                 175     


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            180                 185                 190         


Thr Gly His Thr Tyr Leu Glu Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        195                 200                 205             


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
225                 230                 235                 240 


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                245                 250                 255     


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 270         


Gly Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        275                 280                 285             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    290                 295                 300                 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
305                 310                 315                 320 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
                325                 330                 335     


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
            340                 345                 350         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        355                 360                 365             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    370                 375                 380                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
385                 390                 395                 400 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                405                 410                 415     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            420                 425                 430         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        435                 440                 445             


Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455         


<210>  51
<211>  272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA-scFv

<400>  51

Met Asn Phe Gly Leu Ser Leu Val Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Met Ile Thr Thr Gly Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
                165                 170                 175     


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            180                 185                 190         


Thr Gly His Thr Tyr Leu Glu Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        195                 200                 205             


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
225                 230                 235                 240 


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                245                 250                 255     


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 270         


<210>  52
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA VH

<400>  52

Met Asn Phe Gly Leu Ser Leu Val Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Met Ile Thr Thr Gly Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  53
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA VL

<400>  53

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Thr Gly His Thr Tyr Leu Glu Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  54
<211>  428
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA-Fab-heavy chain-CD28ATD-CD28CSD-CD3zSSD fusion

<400>  54

Met Asn Phe Gly Leu Ser Leu Val Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Met Ile Thr Thr Gly Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Gly Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly 
                245                 250                 255     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            260                 265                 270         


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        275                 280                 285             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    290                 295                 300                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
305                 310                 315                 320 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                325                 330                 335     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            340                 345                 350         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        355                 360                 365             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    370                 375                 380                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
385                 390                 395                 400 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                405                 410                 415     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425             


<210>  55
<211>  243
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA-Fab heavy chain

<400>  55

Met Asn Phe Gly Leu Ser Leu Val Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Met Ile Thr Thr Gly Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys 
            


<210>  56
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-AAA-Fab light chain

<400>  56

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Thr Gly His Thr Tyr Leu Glu Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  57
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG CDR H1 Kabat

<400>  57

Asp Tyr Ala Met Ser 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG CDR H2 Kabat

<400>  58

Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG CDR H3 Kabat

<400>  59

Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met Ala Tyr 
1               5                   10                  15      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG CDR L1 Kabat

<400>  60

Arg Ala Ser Gln Asp Ile Lys Asn Tyr Leu Asn 
1               5                   10      


<210>  61
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG CDR L2 Kabat

<400>  61

Tyr Ser Ser Thr Leu Leu Ser 
1               5           


<210>  62
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG CDR L3 Kabat

<400>  62

Gln Gln Ser Ile Thr Leu Pro Pro Thr 
1               5                   


<210>  63
<211>  437
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG-ds-scFv-CD28ATD-CD28CSD-CD3zSSD fusion

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn 
                165                 170                 175     


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
            180                 185                 190         


Ile Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro 
225                 230                 235                 240 


Pro Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            260                 265                 270         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        275                 280                 285             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    290                 295                 300                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
305                 310                 315                 320 


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                325                 330                 335     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            340                 345                 350         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        355                 360                 365             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    370                 375                 380                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
385                 390                 395                 400 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                405                 410                 415     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            420                 425                 430         


Ala Leu Pro Pro Arg 
        435         


<210>  64
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG-ds VH

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  65
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG-ds VL

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  66
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG-ds-scFv

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn 
                165                 170                 175     


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
            180                 185                 190         


Ile Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro 
225                 230                 235                 240 


Pro Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
                245                 250         


<210>  67
<211>  413
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG-Fab-heavy chain-CD28ATD-CD28CSD-CD3zSSD fusion

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Gly Gly Gly Gly Ser Phe Trp Val Leu Val Val Val 
225                 230                 235                 240 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                245                 250                 255     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            260                 265                 270         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        275                 280                 285             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
    290                 295                 300                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
305                 310                 315                 320 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                325                 330                 335     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            340                 345                 350         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        355                 360                 365             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    370                 375                 380                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
385                 390                 395                 400 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410             


<210>  68
<211>  228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG-Fab heavy chain

<400>  68

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys 
225             


<210>  69
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG-Fab light chain

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  70
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG VH

<400>  70

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  71
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-DIG VL

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  72
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC CDR H1 Kabat

<400>  72

His Tyr Trp Met Asn 
1               5   


<210>  73
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC CDR H2 Kabat

<400>  73

Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  74
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC CDR H3 Kabat

<400>  74

Ala Ser Tyr Gly Met Glu Tyr 
1               5           


<210>  75
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC CDR L1 Kabat

<400>  75

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg 
1               5                   10                  15      


<210>  76
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC CDR L2 Kabat

<400>  76

Lys Val Ser Asn Arg Val Ser 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC CDR L3 Kabat

<400>  77

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  78
<211>  436
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC-scFv-CD28ATD-CD28CSD-CD3zSSD fusion

<400>  78

Gly Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ala Met Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln 
    130                 135                 140                 


Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser 
145                 150                 155                 160 


Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu 
                165                 170                 175     


Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr 
            180                 185                 190         


Lys Val Ser Asn Arg Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu 
    210                 215                 220                 


Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  79
<211>  250
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC-scFv

<400>  79

Gly Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ala Met Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln 
    130                 135                 140                 


Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser 
145                 150                 155                 160 


Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu 
                165                 170                 175     


Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr 
            180                 185                 190         


Lys Val Ser Asn Arg Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu 
    210                 215                 220                 


Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250 


<210>  80
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC VH

<400>  80

Gly Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ala Met Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  81
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FITC VL

<400>  81

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  82
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA CDR H1 Kabat

<400>  82

Asn Tyr Asp Met Ala 
1               5   


<210>  83
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA CDR H2 Kabat

<400>  83

Thr Ile Ser His Asp Gly Arg Asn Thr Asn Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA CDR H3 Kabat

<400>  84

Pro Gly Phe Ala His 
1               5   


<210>  85
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA CDR L1 Kabat

<400>  85

Arg Ser Ser Lys Thr Leu Leu Asn Thr Arg Gly Ile Thr Ser Leu Tyr 
1               5                   10                  15      


<210>  86
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA CDR L2 Kabat

<400>  86

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  87
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA CDR L3 Kabat

<400>  87

Ala Gln Phe Leu Glu Phe Pro Leu Thr 
1               5                   


<210>  88
<211>  431
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA-scFv-CD28ATD-CD28CSD-CD3zSSD fusion

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Val Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Lys Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser His Asp Gly Arg Asn Thr Asn Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Gly Ser Arg Asp Ser Ala Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Gly Pro Gly Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ala Pro Leu Ser 
    130                 135                 140                 


Val Ser Val Ser Pro Gly Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Lys Thr Leu Leu Asn Thr Arg Gly Ile Thr Ser Leu Tyr Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn 
            180                 185                 190         


Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr 
        195                 200                 205             


His Phe Thr Leu Gln Ile Ser Lys Val Glu Thr Glu Asp Val Gly Ile 
    210                 215                 220                 


Tyr Tyr Cys Ala Gln Phe Leu Glu Phe Pro Leu Thr Phe Gly Cys Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Phe Trp Val Leu Val 
                245                 250                 255     


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
            260                 265                 270         


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        275                 280                 285             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    290                 295                 300                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
305                 310                 315                 320 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                325                 330                 335     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            340                 345                 350         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        355                 360                 365             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    370                 375                 380                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                405                 410                 415     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430     


<210>  89
<211>  246
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA-scFv

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Val Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Lys Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser His Asp Gly Arg Asn Thr Asn Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Gly Ser Arg Asp Ser Ala Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Gly Pro Gly Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ala Pro Leu Ser 
    130                 135                 140                 


Val Ser Val Ser Pro Gly Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Lys Thr Leu Leu Asn Thr Arg Gly Ile Thr Ser Leu Tyr Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn 
            180                 185                 190         


Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr 
        195                 200                 205             


His Phe Thr Leu Gln Ile Ser Lys Val Glu Thr Glu Asp Val Gly Ile 
    210                 215                 220                 


Tyr Tyr Cys Ala Gln Phe Leu Glu Phe Pro Leu Thr Phe Gly Cys Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  90
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA VH

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Val Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Lys Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser His Asp Gly Arg Asn Thr Asn Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Gly Ser Arg Asp Ser Ala Gln Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Gly Pro Gly Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  91
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-HA VL

<400>  91

Asp Ile Val Leu Thr Gln Ala Pro Leu Ser Val Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Thr Leu Leu Asn Thr 
            20                  25                  30          


Arg Gly Ile Thr Ser Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr His Phe Thr Leu Gln Ile 
65                  70                  75                  80  


Ser Lys Val Glu Thr Glu Asp Val Gly Ile Tyr Tyr Cys Ala Gln Phe 
                85                  90                  95      


Leu Glu Phe Pro Leu Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  92
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc CDR H1 Kabat

<400>  92

His Tyr Gly Met Ser 
1               5   


<210>  93
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc CDR H2 Kabat

<400>  93

Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  94
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc CDR H3 Kabat

<400>  94

Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr Ser Ala Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  95
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc CDR L1 Kabat

<400>  95

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Phe Ser Phe Met Asn 
1               5                   10                  15  


<210>  96
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc CDR L2 Kabat

<400>  96

Ala Ile Ser Asn Arg Gly Ser 
1               5           


<210>  97
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc CDR L3 Kabat

<400>  97

Gln Gln Thr Lys Glu Val Pro Trp Thr 
1               5                   


<210>  98
<211>  414
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc-Fab-heavy chain-CD28ATD-CD28CSD-CD3zSSD fusion

<400>  98

Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr Ser 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser Ala 
        115                 120                 125             


Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala 
    130                 135                 140                 


Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
            180                 185                 190         


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr 
        195                 200                 205             


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
    210                 215                 220                 


Val Pro Arg Asp Cys Gly Gly Gly Gly Ser Phe Trp Val Leu Val Val 
225                 230                 235                 240 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                245                 250                 255     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            260                 265                 270         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        275                 280                 285             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
    290                 295                 300                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
305                 310                 315                 320 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                325                 330                 335     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            340                 345                 350         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        355                 360                 365             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    370                 375                 380                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
385                 390                 395                 400 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410                 


<210>  99
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc-Fab heavy chain

<400>  99

Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr Ser 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser Ala 
        115                 120                 125             


Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala 
    130                 135                 140                 


Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
            180                 185                 190         


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr 
        195                 200                 205             


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
    210                 215                 220                 


Val Pro Arg Asp Cys 
225                 


<210>  100
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc-Fab light chain

<400>  100

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
        115                 120                 125             


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
145                 150                 155                 160 


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
            180                 185                 190         


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
        195                 200                 205             


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215             


<210>  101
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc VH

<400>  101

Glu Val His Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn Thr Tyr Tyr Tyr Ser 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125         


<210>  102
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-myc VL

<400>  102

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  103
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HA tag

<400>  103

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  104
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Myc tag

<400>  104

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  105
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GCN4 tag

<400>  105

Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys 
1               5                   10          


<210>  106
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AviTag

<400>  106

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  107
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  108
<211>  492
<212>  DNA
<213>  Homo sapiens

<400>  108
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

gcacagagct ttggcctgct ggatcccaaa ctctgctacc tgctggatgg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgcagag      180

ccccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      240

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      300

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      360

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      420

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      480

ccccctcgct aa                                                          492


<210>  109
<211>  164
<212>  PRT
<213>  Mus musculus

<400>  109

Met Lys Trp Lys Val Ser Val Leu Ala Cys Ile Leu His Val Arg Phe 
1               5                   10                  15      


Pro Gly Ala Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Ile Thr Ala 
        35                  40                  45              


Leu Tyr Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn 
    50                  55                  60                  


Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn 
            100                 105                 110         


Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr 
145                 150                 155                 160 


Leu Ala Pro Arg 
                


<210>  110
<211>  495
<212>  DNA
<213>  Mus musculus

<400>  110
atgaagtgga aagtgtctgt tctcgcctgc atcctccacg tgcggttccc aggagcagag       60

gcacagagct ttggtctgct ggatcccaaa ctctgctact tgctagatgg aatcctcttc      120

atctacggag tcatcatcac agccctgtac ctgagagcaa aattcagcag gagtgcagag      180

actgctgcca acctgcagga ccccaaccag ctctacaatg agctcaatct agggcgaaga      240

gaggaatatg acgtcttgga gaagaagcgg gctcgggatc cagagatggg aggcaaacag      300

cagaggagga ggaaccccca ggaaggcgta tacaatgcac tgcagaaaga caagatggca      360

gaagcctaca gtgagatcgg cacaaaaggc gagaggcgga gaggcaaggg gcacgatggc      420

ctttaccagg gtctcagcac tgccaccaag gacacctatg atgccctgca tatgcagacc      480

ctggcccctc gctaa                                                       495


<210>  111
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  111
atgctgcgcc tgctgctggc gctgaacctg tttccgagca ttcaggtgac cggcaacaaa       60

attctggtga aacagagccc gatgctggtg gcgtatgata acgcggtgaa cctgagctgc      120

aaatatagct ataacctgtt tagccgcgaa tttcgcgcga gcctgcataa aggcctggat      180

agcgcggtgg aagtgtgcgt ggtgtatggc aactatagcc agcagctgca ggtgtatagc      240

aaaaccggct ttaactgcga tggcaaactg ggcaacgaaa gcgtgacctt ttatctgcag      300

aacctgtatg tgaaccagac cgatatttat ttttgcaaaa ttgaagtgat gtatccgccg      360

ccgtatctgg ataacgaaaa aagcaacggc accattattc atgtgaaagg caaacatctg      420

tgcccgagcc cgctgtttcc gggcccgagc aaaccgtttt gggtgctggt ggtggtgggc      480

ggcgtgctgg cgtgctatag cctgctggtg accgtggcgt ttattatttt ttgggtgcgc      540

agcaaacgca gccgcctgct gcatagcgat tatatgaaca tgaccccgcg ccgcccgggc      600

ccgacccgca aacattatca gccgtatgcg ccgccgcgcg attttgcggc gtatcgcagc      660


<210>  112
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  113
<211>  654
<212>  DNA
<213>  Mus musculus

<400>  113
atgaccctgc gcctgctgtt tctggcgctg aactttttta gcgtgcaggt gaccgaaaac       60

aaaattctgg tgaaacagag cccgctgctg gtggtggata gcaacgaagt gagcctgagc      120

tgccgctata gctataacct gctggcgaaa gaatttcgcg cgagcctgta taaaggcgtg      180

aacagcgatg tggaagtgtg cgtgggcaac ggcaacttta cctatcagcc gcagtttcgc      240

agcaacgcgg aatttaactg cgatggcgat tttgataacg aaaccgtgac ctttcgcctg      300

tggaacctgc atgtgaacca taccgatatt tatttttgca aaattgaatt tatgtatccg      360

ccgccgtatc tggataacga acgcagcaac ggcaccatta ttcatattaa agaaaaacat      420

ctgtgccata cccagagcag cccgaaactg ttttgggcgc tggtggtggt ggcgggcgtg      480

ctgttttgct atggcctgct ggtgaccgtg gcgctgtgcg tgatttggac caacagccgc      540

cgcaaccgcc tgctgcagag cgattatatg aacatgaccc cgcgccgccc gggcctgacc      600

cgcaaaccgt atcagccgta tgcgccggcg cgcgattttg cggcgtatcg cccg            654


<210>  114
<211>  218
<212>  PRT
<213>  Mus musculus

<400>  114

Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      


Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          


Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              


Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  


Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  


Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      


Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             


<210>  115
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28 YMNM

<400>  115

Tyr Met Asn Met 
1               


<210>  116
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28 PYAP

<400>  116

Pro Tyr Ala Pro 
1               


<210>  117
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  117

Ala Thr Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala 
1               5                   10                  15      


Thr Gly Val His Ser 
            20      


<210>  118
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide DNA sequence

<400>  118
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcactcc          57


<210>  119
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-CD20 (GA101) PGLALA heavy chain

<400>  119

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  120
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-CD20 (GA101) light chain

<400>  120

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  121
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-CEA (CH1A1A98/992F1) PGLALA heavy chain

<400>  121

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  122
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-CEA (CH1A1A98/992F1) light chain

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  123
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human IgG1 Fc

<400>  123

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  124
<211>  372
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-WT1 (33F05) PGLALA heavy chain

<400>  124

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Tyr Tyr Glu Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        115                 120                 125             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  125
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-WT1 (33F05) light chain

<400>  125

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Pro Asp Met Asn Gly Asn Ala 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  126
<211>  376
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-WT1 (11D06) PGLALA heavy chain

<400>  126

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ile Glu Leu Trp Trp Gly Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        115                 120                 125             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    130                 135                 140                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
145                 150                 155                 160 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                165                 170                 175     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            180                 185                 190         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        195                 200                 205             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    210                 215                 220                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
225                 230                 235                 240 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                245                 250                 255     


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            260                 265                 270         


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        275                 280                 285             


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
    290                 295                 300                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
305                 310                 315                 320 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
                325                 330                 335     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            340                 345                 350         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        355                 360                 365             


Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375     


<210>  127
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-WT1 (11D06) light chain

<400>  127

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Asp Tyr Thr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  128
<211>  375
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-WT1 (33H09) PGLALA heavy chain

<400>  128

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Asp Leu Phe Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        115                 120                 125             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    130                 135                 140                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                245                 250                 255     


Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
                325                 330                 335     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys 
    370                 375 


<210>  129
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-WT1 (33H09) light chain

<400>  129

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Gly Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  130
<211>  375
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-WT1 (5E11) PGLALA heavy chain

<400>  130

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Tyr Asp Leu Tyr Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        115                 120                 125             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    130                 135                 140                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                245                 250                 255     


Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
                325                 330                 335     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys 
    370                 375 


<210>  131
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-WT1 (5E11) light chain

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Phe Pro Pro Met 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  132
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  132

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


