                               SEQUENCE LISTING

<110> ASKLEPIOS BIOPHARMACEUTICAL, INC.
 
<120> LIVER TROPIC RECOMBINANT AAV6 VECTORS THAT EVADE NEUTRALIZATION

<130> 046192-091920WOPT

<140>
<141>

<150> 62/649,691
<151> 2018-03-29

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 732
<212> PRT
<213> Adeno-associated virus 6

<400> 1
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Thr Pro Ala Ala Val Gly Pro Thr Thr Ala Ser Gly Gly Gly Ala Pro 
        195                 200                 205             


Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly 
    210                 215                 220                 


Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr 
225                 230                 235                 240 


Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys 
                245                 250                 255     


Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His Tyr Phe 
            260                 265                 270         


Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys 
        275                 280                 285             


His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly 
    290                 295                 300                 


Phe Arg Pro Lys Arg Leu Asn Phe Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr Gln Asn 
        435                 440                 445             


Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser Arg Gly Ser 
    450                 455                 460                 


Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn Gly Arg Glu 
            500                 505                 510         


Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys Asp Asp Lys 
        515                 520                 525             


Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly Glu Ser Ala 
    530                 535                 540                 


Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile Thr Asp Glu Glu 
545                 550                 555                 560 


Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg Phe Gly Thr Val 
                565                 570                 575     


Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala Thr Gly Asp Val 
            580                 585                 590         


His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val 
        595                 600                 605             


Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His 
    610                 615                 620                 


Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro 
625                 630                 635                 640 


Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Ala 
                645                 650                 655     


Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr 
            660                 665                 670         


Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser 
        675                 680                 685             


Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr Ala Lys Ser 
    690                 695                 700                 


Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr Thr Glu Pro 
705                 710                 715                 720 


Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730         


<210> 2
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Ser Glu Glu Arg 
1               


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Thr Pro Gly Gly Asn Ala Thr Arg 
1               5               


<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Asp Leu Asp Pro Lys Ala Thr Glu Val Glu 
1               5                   10  


<210> 5
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (25)..(29)
<223> a, c, t, g, unknown or other

<400> 5
ccctacacga cgctcttccg atctnnnnnc agaactcaaa atcagtccgg aagt             54


<210> 6
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (33)..(37)
<223> a, c, t, g, unknown or other

<400> 6
gactggagtt cagacgtgtg ctcttccgat ctnnnnngcc aggtaatgct cccatagc         58


<210> 7
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
ccttcgcttc aaaaaatgga ac                                                22


<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
aaaagcactc tgattgacaa atac                                              24


