                               SEQUENCE LISTING

<110> ALTOR BIOSCIENCE LLC
 
<120> ANTI-PDL1, IL-15 AND TGF-BETA RECEPTOR COMBINATION MOLECULES

<130> 055537-508001WO

<140> PCT/US2019/024077
<141> 2019-03-26

<150> 62/734,994
<151> 2018-09-21

<150> 62/648,373
<151> 2018-03-26

<160> 46    

<170> PatentIn version 3.5

<210> 1
<211> 1806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacatcac gtgtcctcct cctatgtccg tggaacacgc agacatctgg      960

gtcaagagct acagcttgta ctccagggag cggtacattt gtaactctgg tttcaagcgt     1020

aaagccggca cgtccagcct gacggagtgc gtgttgaaca aggccacgaa tgtcgcccac     1080

tggacaaccc ccagtctcaa atgcattaga gagccgaaat cttgtgacaa aactcacaca     1140

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1200

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1260

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1320

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1380

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1440

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1500

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1560

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1620

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1680

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1740

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctcct     1800

ggtaaa                                                                1806


<210> 2
<211> 602
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    370                 375                 380                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
385                 390                 395                 400 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                405                 410                 415     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            420                 425                 430         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        435                 440                 445             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    450                 455                 460                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
465                 470                 475                 480 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                485                 490                 495     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            500                 505                 510         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        515                 520                 525             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    530                 535                 540                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
545                 550                 555                 560 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                565                 570                 575     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            580                 585                 590         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600         


<210> 3
<211> 1123
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccaacatc       60

cagatgaccc agtcccctag ctccgtgtcc gcctccgtgg gagatcgggt gaccatcacc      120

tgtagggcct cccaggacat ctccaggtgg ctggcctggt accagcagaa gcccggcaag      180

gcccccaagc tgctgatcta cgccgcctcc tccctgcagt ccggagtgcc tagcaggttc      240

tccggctccg gatccggcac agacttcgcc ctgaccatct cctccctgca gcccgaggac      300

ttcgccacct actactgcca gcaggccgac tccaggttct ccatcacctt cggccagggc      360

accaggctgg agatcaagag ggggaggtgg cggatccgga ggtggaggtt ctggtggagg      420

tgggagtgag gtgcagctgg tgcagtccgg aggaggactg gtgcagcctg gcggatccct      480

gaggctgtcc tgtgccgctt ccggcttcac cttcagctcc tactccatga actgggtgag      540

gcaggcccct ggaaagggcc tggagtgggt gtcctacatc tccagctcct cctccaccat      600

ccagtacgcc gactccgtga agggcaggtt caccatctcc agggacaacg ccaagaactc      660

cctgtacctg cagatgaaca gcctgaggga cgaggacacc gccgtgtact actgcgccag      720

gggcgactat tactacggca tggacgtgtg gggccaggga accaccgtga ccgtgtcctc      780

caactgggtt aacgtaataa gtgatttgaa aaaaattgaa gatcttattc aatctatgca      840

tattgatgct actttatata cggaaagtga tgttcacccc agttgcaaag taacagcaat      900

gaagtgcttt ctcttggagt tacaagttat ttcacttgag tccggagatg caagtattca      960

tgatacagta gaaaatctga tcatcctagc aaacgacagt ttgtcttcta atgggaatgt     1020

aacagaatct ggatgcaaag aatgtgagga actggaggaa aaaaatatta aagaattttt     1080

gcagagtttt gtacatattg tccaaatgtt catcaacact tct                       1123


<210> 4
<211> 374
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
            20                  25                  30          


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    50                  55                  60                  


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
                85                  90                  95      


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
            100                 105                 110         


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
                165                 170                 175     


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
            180                 185                 190         


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
                245                 250                 255     


Thr Val Ser Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        275                 280                 285             


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    290                 295                 300                 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
305                 310                 315                 320 


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
                325                 330                 335     


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            340                 345                 350         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        355                 360                 365             


Met Phe Ile Asn Thr Ser 
    370                 


<210> 5
<211> 1671
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccaacatc       60

cagatgaccc agtcccctag ctccgtgtcc gcctccgtgg gagatcgggt gaccatcacc      120

tgtagggcct cccaggacat ctccaggtgg ctggcctggt accagcagaa gcccggcaag      180

gcccccaagc tgctgatcta cgccgcctcc tccctgcagt ccggagtgcc tagcaggttc      240

tccggctccg gatccggcac agacttcgcc ctgaccatct cctccctgca gcccgaggac      300

ttcgccacct actactgcca gcaggccgac tccaggttct ccatcacctt cggccagggc      360

accaggctgg agatcaagag gggaggtggc ggatccggag gtggaggttc tggtggaggt      420

gggagtgagg tgcagctggt gcagtccgga ggaggactgg tgcagcctgg cggatccctg      480

aggctgtcct gtgccgcttc cggcttcacc ttcagctcct actccatgaa ctgggtgagg      540

caggcccctg gaaagggcct ggagtgggtg tcctacatct ccagctcctc ctccaccatc      600

cagtacgccg actccgtgaa gggcaggttc accatctcca gggacaacgc caagaactcc      660

ctgtacctgc agatgaacag cctgagggac gaggacaccg ccgtgtacta ctgcgccagg      720

ggcgactatt actacggcat ggacgtgtgg ggccagggaa ccaccgtgac cgtgtcctcc      780

atcacgtgtc ctcctcctat gtccgtggaa cacgcagaca tctgggtcaa gagctacagc      840

ttgtactcca gggagcggta catttgtaac tctggtttca agcgtaaagc cggcacgtcc      900

agcctgacgg agtgcgtgtt gaacaaggcc acgaatgtcg cccactggac aacccccagt      960

ctcaaatgca ttagagagcc gaaatcttgt gacaaaactc acacatgccc accgtgccca     1020

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1080

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1140

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1200

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1260

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1320

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1380

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1440

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1500

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1560

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1620

gctctgcaca accactacac gcagaagagc ctctccctgt ctcctggtaa a              1671


<210> 6
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
            20                  25                  30          


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    50                  55                  60                  


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
                85                  90                  95      


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
            100                 105                 110         


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
                165                 170                 175     


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
            180                 185                 190         


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
                245                 250                 255     


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
            260                 265                 270         


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
        275                 280                 285             


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
    290                 295                 300                 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
305                 310                 315                 320 


Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                325                 330                 335     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            340                 345                 350         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        355                 360                 365             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    370                 375                 380                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
385                 390                 395                 400 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                405                 410                 415     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            420                 425                 430         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        435                 440                 445             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    450                 455                 460                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
465                 470                 475                 480 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                485                 490                 495     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            500                 505                 510         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        515                 520                 525             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    530                 535                 540                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555         


<210> 7
<211> 1257
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacaactg ggttaacgta ataagtgatt tgaaaaaaat tgaagatctt      960

attcaatcta tgcatattga tgctacttta tatacggaaa gtgatgttca ccccagttgc     1020

aaagtaacag caatgaagtg ctttctcttg gagttacaag ttatttcact tgagtccgga     1080

gatgcaagta ttcatgatac agtagaaaat ctgatcatcc tagcaaacga cagtttgtct     1140

tctaatggga atgtaacaga atctggatgc aaagaatgtg aggaactgga ggaaaaaaat     1200

attaaagaat ttttgcagag ttttgtacat attgtccaaa tgttcatcaa cacttct        1257


<210> 8
<211> 419
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
305                 310                 315                 320 


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                325                 330                 335     


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
            340                 345                 350         


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
        355                 360                 365             


Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn 
    370                 375                 380                 


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
385                 390                 395                 400 


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                405                 410                 415     


Asn Thr Ser 
            


<210> 9
<211> 396
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccaactgg       60

gttaacgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacgac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttct                                396


<210> 10
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser 
    130         


<210> 11
<211> 2079
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccaacatc       60

cagatgaccc agtcccctag ctccgtgtcc gcctccgtgg gagatcgggt gaccatcacc      120

tgtagggcct cccaggacat ctccaggtgg ctggcctggt accagcagaa gcccggcaag      180

gcccccaagc tgctgatcta cgccgcctcc tccctgcagt ccggagtgcc tagcaggttc      240

tccggctccg gatccggcac agacttcgcc ctgaccatct cctccctgca gcccgaggac      300

ttcgccacct actactgcca gcaggccgac tccaggttct ccatcacctt cggccagggc      360

accaggctgg agatcaagag gggaggtggc ggatccggag gtggaggttc tggtggaggt      420

gggagtgagg tgcagctggt gcagtccgga ggaggactgg tgcagcctgg cggatccctg      480

aggctgtcct gtgccgcttc cggcttcacc ttcagctcct actccatgaa ctgggtgagg      540

caggcccctg gaaagggcct ggagtgggtg tcctacatct ccagctcctc ctccaccatc      600

cagtacgccg actccgtgaa gggcaggttc accatctcca gggacaacgc caagaactcc      660

ctgtacctgc agatgaacag cctgagggac gaggacaccg ccgtgtacta ctgcgccagg      720

ggcgactatt actacggcat ggacgtgtgg ggccagggaa ccaccgtgac cgtgtcctcc      780

atcacgtgtc ctcctcctat gtccgtggaa cacgcagaca tctgggtcaa gagctacagc      840

ttgtactcca gggagcggta catttgtaac tctggtttca agcgtaaagc cggcacgtcc      900

agcctgacgg agtgcgtgtt gaacaaggcc acgaatgtcg cccactggac aacccccagt      960

ctcaaatgca ttagagagcc gaaatcttgt gacaaaactc acacatgccc accgtgccca     1020

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1080

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1140

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1200

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1260

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1320

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1380

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1440

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1500

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1560

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1620

gctctgcaca accactacac gcagaagagc ctctccctgt ctcctggtaa aatccccccc     1680

cacgtgcaga agtccgttaa caacgacatg atcgtgaccg acaacaacgg cgccgtgaag     1740

ttcccccagc tgtgcaagtt ctgcgacgtg aggttctcca cctgcgacaa ccagaagtcc     1800

tgcatgtcca actgctccat cacctccatc tgcgagaagc ctcaggaggt gtgcgtggct     1860

gtgtggcgga agaacgacga gaacatcacc ctggagaccg tgtgccacga ccccaagctg     1920

ccctaccacg acttcatcct ggaggacgcc gcctccccca agtgcatcat gaaggagaag     1980

aagaagcccg gcgagacctt ctttatgtgc tcctgctcca gcgacgagtg caacgacaac     2040

atcatcttct ccgaggagta caacacctcc aaccccgac                            2079


<210> 12
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
            20                  25                  30          


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    50                  55                  60                  


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
                85                  90                  95      


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
            100                 105                 110         


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
                165                 170                 175     


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
            180                 185                 190         


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
                245                 250                 255     


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
            260                 265                 270         


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
        275                 280                 285             


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
    290                 295                 300                 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
305                 310                 315                 320 


Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                325                 330                 335     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            340                 345                 350         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        355                 360                 365             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    370                 375                 380                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
385                 390                 395                 400 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                405                 410                 415     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            420                 425                 430         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        435                 440                 445             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    450                 455                 460                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
465                 470                 475                 480 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                485                 490                 495     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            500                 505                 510         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        515                 520                 525             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    530                 535                 540                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Pro Pro 
545                 550                 555                 560 


His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn 
                565                 570                 575     


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
            580                 585                 590         


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
        595                 600                 605             


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
    610                 615                 620                 


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
625                 630                 635                 640 


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
                645                 650                 655     


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
            660                 665                 670         


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
        675                 680                 685             


Thr Ser Asn Pro Asp 
    690             


<210> 13
<211> 2142
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccaacatc       60

cagatgaccc agtcccctag ctccgtgtcc gcctccgtgg gagatcgggt gaccatcacc      120

tgtagggcct cccaggacat ctccaggtgg ctggcctggt accagcagaa gcccggcaag      180

gcccccaagc tgctgatcta cgccgcctcc tccctgcagt ccggagtgcc tagcaggttc      240

tccggctccg gatccggcac agacttcgcc ctgaccatct cctccctgca gcccgaggac      300

ttcgccacct actactgcca gcaggccgac tccaggttct ccatcacctt cggccagggc      360

accaggctgg agatcaagag gggaggtggc ggatccggag gtggaggttc tggtggaggt      420

gggagtgagg tgcagctggt gcagtccgga ggaggactgg tgcagcctgg cggatccctg      480

aggctgtcct gtgccgcttc cggcttcacc ttcagctcct actccatgaa ctgggtgagg      540

caggcccctg gaaagggcct ggagtgggtg tcctacatct ccagctcctc ctccaccatc      600

cagtacgccg actccgtgaa gggcaggttc accatctcca gggacaacgc caagaactcc      660

ctgtacctgc agatgaacag cctgagggac gaggacaccg ccgtgtacta ctgcgccagg      720

ggcgactatt actacggcat ggacgtgtgg ggccagggaa ccaccgtgac cgtgtcctcc      780

atcacgtgtc ctcctcctat gtccgtggaa cacgcagaca tctgggtcaa gagctacagc      840

ttgtactcca gggagcggta catttgtaac tctggtttca agcgtaaagc cggcacgtcc      900

agcctgacgg agtgcgtgtt gaacaaggcc acgaatgtcg cccactggac aacccccagt      960

ctcaaatgca ttagagagcc gaaatcttgt gacaaaactc acacatgccc accgtgccca     1020

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1080

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1140

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1200

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1260

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1320

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1380

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1440

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1500

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1560

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1620

gctctgcaca accactacac gcagaagagc ctctccctgt ctcctggtaa aggaggaggt     1680

ggctccggag gcggtggctc cggtggaggt ggctccggag gtggcggttc cggtatcccc     1740

ccccacgtgc agaagtccgt taacaacgac atgatcgtga ccgacaacaa cggcgccgtg     1800

aagttccccc agctgtgcaa gttctgcgac gtgaggttct ccacctgcga caaccagaag     1860

tcctgcatgt ccaactgctc catcacctcc atctgcgaga agcctcagga ggtgtgcgtg     1920

gctgtgtggc ggaagaacga cgagaacatc accctggaga ccgtgtgcca cgaccccaag     1980

ctgccctacc acgacttcat cctggaggac gccgcctccc ccaagtgcat catgaaggag     2040

aagaagaagc ccggcgagac cttctttatg tgctcctgct ccagcgacga gtgcaacgac     2100

aacatcatct tctccgagga gtacaacacc tccaaccccg ac                        2142


<210> 14
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
            20                  25                  30          


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    50                  55                  60                  


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
                85                  90                  95      


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
            100                 105                 110         


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
                165                 170                 175     


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
            180                 185                 190         


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
                245                 250                 255     


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
            260                 265                 270         


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
        275                 280                 285             


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
    290                 295                 300                 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
305                 310                 315                 320 


Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                325                 330                 335     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            340                 345                 350         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        355                 360                 365             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    370                 375                 380                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
385                 390                 395                 400 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                405                 410                 415     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            420                 425                 430         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        435                 440                 445             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    450                 455                 460                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
465                 470                 475                 480 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                485                 490                 495     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            500                 505                 510         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        515                 520                 525             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    530                 535                 540                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            580                 585                 590         


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        595                 600                 605             


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    610                 615                 620                 


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
625                 630                 635                 640 


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                645                 650                 655     


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            660                 665                 670         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        675                 680                 685             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    690                 695                 700                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
705                 710                 


<210> 15
<211> 1260
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacaactg ggtgaatgta ataagtgatt tgaaaaaaat tgaagatctt      960

attcaatcta tgcatattga tgctacttta tatacggaaa gtgatgttca ccccagttgc     1020

aaagtaacag caatgaagtg ctttctcttg gagttacaag ttatttcact tgagtccgga     1080

gatgcaagta ttcatgatac agtagaaaat ctgatcatcc tagcaaacga cagtttgtct     1140

tctaatggga atgtaacaga atctggatgc aaagaatgtg aggaactgga ggaaaaaaat     1200

attaaagaat ttttgcagag ttttgtacat attgtccaaa tgttcatcaa cacttcttaa     1260


<210> 16
<211> 1161
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcac gatcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atgagcccaa atcttgtgac      480

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      540

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      600

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      660

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      720

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      780

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      840

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac      900

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg      960

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1020

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1080

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1140

tccctgtctc cgggtaaata a                                               1161


<210> 17
<211> 1809
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcac gatcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg cacaatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacatcac gtgtcctcct cctatgtccg tggaacacgc agacatctgg      960

gtcaagagct acagcttgta ctccagggag cggtacattt gtaactctgg tttcaagcgt     1020

aaagccggca cgtccagcct gacggagtgc gtgttgaaca aggccacgaa tgtcgcccac     1080

tggacaaccc ccagtctcaa atgtattaga gagcccaaat cttgtgacaa aactcacaca     1140

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1200

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1260

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1320

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1380

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1440

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1500

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1560

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1620

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1680

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1740

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1800

ggtaaataa                                                             1809


<210> 18
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
aactgggtga atgtaataag tgatttgaaa aaaattgaag atcttatcca gtccatgcac       60

atcgacgcca ccctgtacac cgagagcgac gtgcacccct cctgcaaggt gaccgccatg      120

aagtgcttcc tgctggagct gcaggtgatc tccctggagt ccggcgacgc ctccatccac      180

gacaccgtgg agaacctgat catcctggcc aacgactccc tgtcctccaa cggcaacgtg      240

accgagtccg gctgcaagga gtgcgaggag ctggaggaga agaacatcaa ggagttcctg      300

cagtccttcg tgcacatcgt ccaaatgttc atcaacactt ct                         342


<210> 19
<211> 2148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ccaccggtgt ccactccaac       60

atccagatga cccagtctcc atcttctgtg tctgcatctg taggagacag agtcaccatc      120

acttgtcggg cgagtcagga tattagccgc tggttagcct ggtatcagca gaaaccaggg      180

aaagccccta aactcctgat ctatgctgca tccagtttgc aaagtggggt cccatcgagg      240

ttcagcggca gtggatctgg gacagatttc gctctcacta tcagcagcct gcagcctgaa      300

gattttgcaa cttactattg tcaacaggct gacagtcgtt tctcgatcac cttcggccaa      360

gggacacgac tggagattaa acgaggaggt ggcggatccg gaggtggagg ttctggtgga      420

ggtgggagtg aggtgcagct ggtgcagtct gggggaggct tggtacagcc tggggggtcc      480

ctgagactct cctgtgcagc ctctggattc accttcagta gctatagcat gaactgggtc      540

cgccaggctc cagggaaggg gctggagtgg gtttcataca ttagtagtag tagtagtacc      600

atacagtacg cagactctgt gaagggccga ttcaccatct ccagagacaa tgccaagaac      660

tcactgtatc tgcaaatgaa cagcctgaga gacgaggaca cggctgtgta ttactgtgcg      720

agaggggact actactacgg tatggacgtc tggggccaag ggaccacggt caccgtgagc      780

tcaatcacgt gtcctcctcc tatgtccgtg gaacacgcag acatctgggt caagagctac      840

agcttgtact ccagggagcg gtacatttgt aactctggtt tcaagcgtaa agccggcacg      900

tccagcctga cggagtgcgt gttgaacaag gccacgaatg tcgcccactg gacaaccccc      960

agtctcaaat gcattagaga gccgaaatct tgtgacaaaa ctcacacatg cccaccgtgc     1020

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1080

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1140

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1200

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1260

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1320

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1380

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1440

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1500

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1560

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1620

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctcctgg taaaggagga     1680

ggtggctccg gaggcggtgg ctccggtgga ggtggctccg gaggtggcgg ttccggtatc     1740

cccccccacg tgcagaagtc cgttaacaac gacatgatcg tgaccgacaa caacggcgcc     1800

gtgaagttcc cccagctgtg caagttctgc gacgtgaggt tctccacctg cgacaaccag     1860

aagtcctgca tgtccaactg cccaatcacc tccatctgcg agaagcctca ggaggtgtgc     1920

gtggctgtgt ggcggaagaa cgacgagaac atcaccctgg agaccgtgtg ccacgacccc     1980

aagctgccct accacgactt catcctggag gacgccgcct cccccaagtg catcatgaag     2040

gagaagaaga agcccggcga gaccttcttt atgtgctcct gctccagcga cgagtgcaac     2100

gacaacatca tcttctccga ggagtacaac acctccaacc ccgactga                  2148


<210> 20
<211> 114
<212> PRT
<213> Homo sapiens

<400> 20
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 21
<211> 810
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
        115                 120                 125             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
    130                 135                 140                 


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
145                 150                 155                 160 


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
        195                 200                 205             


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
225                 230                 235                 240 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                245                 250                 255     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
            260                 265                 270         


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
        275                 280                 285             


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
    290                 295                 300                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
305                 310                 315                 320 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                325                 330                 335     


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            340                 345                 350         


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        355                 360                 365             


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    370                 375                 380                 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
385                 390                 395                 400 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                405                 410                 415     


Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            420                 425                 430         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
        675                 680                 685             


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
    690                 695                 700                 


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Gln 
705                 710                 715                 720 


Asn Cys Pro Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
                725                 730                 735     


Ala Val Trp Arg Lys Gln Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
            740                 745                 750         


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
        755                 760                 765             


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
    770                 775                 780                 


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
785                 790                 795                 800 


Ser Glu Glu Tyr Gln Thr Ser Asn Pro Asp 
                805                 810 


<210> 22
<211> 810
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
        115                 120                 125             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
    130                 135                 140                 


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
145                 150                 155                 160 


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
        195                 200                 205             


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
225                 230                 235                 240 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                245                 250                 255     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
            260                 265                 270         


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
        275                 280                 285             


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
    290                 295                 300                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
305                 310                 315                 320 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                325                 330                 335     


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            340                 345                 350         


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        355                 360                 365             


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    370                 375                 380                 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
385                 390                 395                 400 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                405                 410                 415     


Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            420                 425                 430         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
        675                 680                 685             


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
    690                 695                 700                 


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Gln 
705                 710                 715                 720 


Asn Cys Pro Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
                725                 730                 735     


Ala Val Trp Arg Lys Gln Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
            740                 745                 750         


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
        755                 760                 765             


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
    770                 775                 780                 


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
785                 790                 795                 800 


Ser Glu Glu Tyr Gln Thr Ser Asn Pro Asp 
                805                 810 


<210> 23
<211> 810
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
        115                 120                 125             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
    130                 135                 140                 


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
145                 150                 155                 160 


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
        195                 200                 205             


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
225                 230                 235                 240 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                245                 250                 255     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
            260                 265                 270         


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
        275                 280                 285             


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
    290                 295                 300                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
305                 310                 315                 320 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                325                 330                 335     


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            340                 345                 350         


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        355                 360                 365             


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    370                 375                 380                 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
385                 390                 395                 400 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                405                 410                 415     


Leu Lys Cys Ile Arg Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
            420                 425                 430         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
        675                 680                 685             


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
    690                 695                 700                 


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Gln 
705                 710                 715                 720 


Asn Cys Pro Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
                725                 730                 735     


Ala Val Trp Arg Lys Gln Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
            740                 745                 750         


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
        755                 760                 765             


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
    770                 775                 780                 


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
785                 790                 795                 800 


Ser Glu Glu Tyr Gln Thr Ser Asn Pro Asp 
                805                 810 


<210> 24
<211> 805
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
        115                 120                 125             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
    130                 135                 140                 


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
145                 150                 155                 160 


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
        195                 200                 205             


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
225                 230                 235                 240 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                245                 250                 255     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
            260                 265                 270         


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
        275                 280                 285             


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
    290                 295                 300                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
305                 310                 315                 320 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                325                 330                 335     


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            340                 345                 350         


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        355                 360                 365             


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    370                 375                 380                 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
385                 390                 395                 400 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                405                 410                 415     


Leu Lys Cys Ile Arg Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            420                 425                 430         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        435                 440                 445             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    450                 455                 460                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
465                 470                 475                 480 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                485                 490                 495     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            500                 505                 510         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        515                 520                 525             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    530                 535                 540                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
545                 550                 555                 560 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                565                 570                 575     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            580                 585                 590         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        595                 600                 605             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    610                 615                 620                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
625                 630                 635                 640 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Pro Pro 
            660                 665                 670         


His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn 
        675                 680                 685             


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
    690                 695                 700                 


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Asn Asn Cys Pro Ile Thr 
705                 710                 715                 720 


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
                725                 730                 735     


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
            740                 745                 750         


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
        755                 760                 765             


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
    770                 775                 780                 


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
785                 790                 795                 800 


Thr Ser Asn Pro Asp 
                805 


<210> 25
<211> 810
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Gln Cys Phe Leu Ser Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Thr Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Tyr Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Ala Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
        115                 120                 125             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
    130                 135                 140                 


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
145                 150                 155                 160 


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
        195                 200                 205             


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
225                 230                 235                 240 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                245                 250                 255     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
            260                 265                 270         


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
        275                 280                 285             


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
    290                 295                 300                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
305                 310                 315                 320 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                325                 330                 335     


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            340                 345                 350         


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        355                 360                 365             


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    370                 375                 380                 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
385                 390                 395                 400 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                405                 410                 415     


Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            420                 425                 430         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
        675                 680                 685             


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
    690                 695                 700                 


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
705                 710                 715                 720 


Asn Cys Pro Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
                725                 730                 735     


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
            740                 745                 750         


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
        755                 760                 765             


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
    770                 775                 780                 


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
785                 790                 795                 800 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
                805                 810 


<210> 26
<211> 810
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Ser Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
        115                 120                 125             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
    130                 135                 140                 


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
145                 150                 155                 160 


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
        195                 200                 205             


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
225                 230                 235                 240 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                245                 250                 255     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
            260                 265                 270         


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
        275                 280                 285             


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
    290                 295                 300                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
305                 310                 315                 320 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                325                 330                 335     


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            340                 345                 350         


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        355                 360                 365             


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    370                 375                 380                 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
385                 390                 395                 400 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                405                 410                 415     


Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            420                 425                 430         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
        675                 680                 685             


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
    690                 695                 700                 


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
705                 710                 715                 720 


Asn Cys Pro Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
                725                 730                 735     


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
            740                 745                 750         


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
        755                 760                 765             


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
    770                 775                 780                 


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
785                 790                 795                 800 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
                805                 810 


<210> 27
<211> 356
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg Phe Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser 
                165                 170                 175     


Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asp 
    210                 215                 220                 


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
                245                 250                 255     


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
            260                 265                 270         


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
        275                 280                 285             


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
    290                 295                 300                 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly 
305                 310                 315                 320 


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
                325                 330                 335     


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
            340                 345                 350         


Ile Asn Thr Ser 
        355     


<210> 28
<211> 454
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
65                  70                  75                  80  


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                85                  90                  95      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        115                 120                 125             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    130                 135                 140                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
145                 150                 155                 160 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                165                 170                 175     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            180                 185                 190         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        195                 200                 205             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    210                 215                 220                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
225                 230                 235                 240 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                245                 250                 255     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            260                 265                 270         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        275                 280                 285             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Pro 
305                 310                 315                 320 


Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn 
                325                 330                 335     


Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg 
            340                 345                 350         


Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Pro Ile 
        355                 360                 365             


Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg 
    370                 375                 380                 


Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys 
385                 390                 395                 400 


Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys 
                405                 410                 415     


Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser 
            420                 425                 430         


Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr 
        435                 440                 445             


Asn Thr Ser Asn Pro Asp 
    450                 


<210> 29
<211> 356
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg Phe Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser 
                165                 170                 175     


Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asp 
    210                 215                 220                 


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
                245                 250                 255     


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
            260                 265                 270         


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
        275                 280                 285             


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
    290                 295                 300                 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly 
305                 310                 315                 320 


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
                325                 330                 335     


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
            340                 345                 350         


Ile Asn Thr Ser 
        355     


<210> 30
<211> 454
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
65                  70                  75                  80  


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                85                  90                  95      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        115                 120                 125             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    130                 135                 140                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
145                 150                 155                 160 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                165                 170                 175     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            180                 185                 190         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        195                 200                 205             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    210                 215                 220                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
225                 230                 235                 240 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                245                 250                 255     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            260                 265                 270         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        275                 280                 285             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Pro 
305                 310                 315                 320 


Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn 
                325                 330                 335     


Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg 
            340                 345                 350         


Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Gln Asn Cys Pro Ile 
        355                 360                 365             


Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg 
    370                 375                 380                 


Lys Gln Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys 
385                 390                 395                 400 


Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys 
                405                 410                 415     


Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser 
            420                 425                 430         


Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr 
        435                 440                 445             


Gln Thr Ser Asn Pro Asp 
    450                 


<210> 31
<211> 356
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg Phe Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser 
                165                 170                 175     


Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asp 
    210                 215                 220                 


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
                245                 250                 255     


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
            260                 265                 270         


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
        275                 280                 285             


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
    290                 295                 300                 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly 
305                 310                 315                 320 


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
                325                 330                 335     


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
            340                 345                 350         


Ile Asn Thr Ser 
        355     


<210> 32
<211> 433
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Ile Thr Cys Pro Pro Pro Met Ser 
    130                 135                 140                 


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
145                 150                 155                 160 


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
                165                 170                 175     


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
            180                 185                 190         


Thr Thr Pro Ser Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys 
        195                 200                 205             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    210                 215                 220                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
225                 230                 235                 240 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                245                 250                 255     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            260                 265                 270         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        275                 280                 285             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                325                 330                 335     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            340                 345                 350         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        355                 360                 365             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
385                 390                 395                 400 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430         


Lys 
    


<210> 33
<211> 356
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg Phe Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser 
                165                 170                 175     


Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asp 
    210                 215                 220                 


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
                245                 250                 255     


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
            260                 265                 270         


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
        275                 280                 285             


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
    290                 295                 300                 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly 
305                 310                 315                 320 


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
                325                 330                 335     


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
            340                 345                 350         


Ile Asn Thr Ser 
        355     


<210> 34
<211> 433
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Gln Asn Cys 
        35                  40                  45              


Pro Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Gln Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Gln Thr Ser Asn Pro Asp Ile Thr Cys Pro Pro Pro Met Ser 
    130                 135                 140                 


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
145                 150                 155                 160 


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
                165                 170                 175     


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
            180                 185                 190         


Thr Thr Pro Ser Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys 
        195                 200                 205             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    210                 215                 220                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
225                 230                 235                 240 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                245                 250                 255     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            260                 265                 270         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        275                 280                 285             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                325                 330                 335     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            340                 345                 350         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        355                 360                 365             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
385                 390                 395                 400 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430         


Lys 
    


<210> 35
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Gln Asn Cys 
        35                  40                  45              


Pro Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Gln Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Gln Thr Ser Asn Pro Asp 
    130                 135     


<210> 36
<211> 297
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
65                  70                  75                  80  


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                85                  90                  95      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        115                 120                 125             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    130                 135                 140                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
145                 150                 155                 160 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                165                 170                 175     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            180                 185                 190         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        195                 200                 205             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    210                 215                 220                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
225                 230                 235                 240 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                245                 250                 255     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            260                 265                 270         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        275                 280                 285             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295         


<210> 37
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
65                  70                  75                  80  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Lys 
    290         


<210> 38
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Gln Cys Phe Leu Ser Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Thr Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Tyr Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Ala Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 39
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Ser Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 40
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Glu Pro Lys Ser Cys 
1               5   


<210> 41
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Pro Glu Leu Leu Gly Gly 
1               5       


<210> 42
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Pro Glu Ala Ala Gly Gly 
1               5       


<210> 43
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Lys Cys Lys Ser Leu 
1               5   


<210> 44
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Lys Cys Ala Ser Leu 
1               5   


<210> 45
<211> 297
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
65                  70                  75                  80  


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                85                  90                  95      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        115                 120                 125             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    130                 135                 140                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
145                 150                 155                 160 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                165                 170                 175     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            180                 185                 190         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        195                 200                 205             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    210                 215                 220                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
225                 230                 235                 240 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                245                 250                 255     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            260                 265                 270         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        275                 280                 285             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295         


<210> 46
<211> 810
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
        115                 120                 125             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser 
    130                 135                 140                 


Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
145                 150                 155                 160 


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu 
            180                 185                 190         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Arg 
        195                 200                 205             


Phe Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
225                 230                 235                 240 


Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                245                 250                 255     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
            260                 265                 270         


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr 
        275                 280                 285             


Ile Ser Ser Ser Ser Ser Thr Ile Gln Tyr Ala Asp Ser Val Lys Gly 
    290                 295                 300                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
305                 310                 315                 320 


Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                325                 330                 335     


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            340                 345                 350         


Thr Val Ser Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        355                 360                 365             


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    370                 375                 380                 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
385                 390                 395                 400 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                405                 410                 415     


Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            420                 425                 430         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
        675                 680                 685             


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
    690                 695                 700                 


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Asn 
705                 710                 715                 720 


Asn Cys Pro Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
                725                 730                 735     


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
            740                 745                 750         


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
        755                 760                 765             


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
    770                 775                 780                 


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
785                 790                 795                 800 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
                805                 810 


