                         SEQUENCE LISTING

<110>  Merus N.V.
 
<120>  Multivalent antibody

<130>  P118963PC00

<150>  US 62/650,467
<151>  2018-03-30

<160>  302   

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Ser Lys Tyr Gly Pro Pro 
1               5           


<210>  2
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  3

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  4

Glu Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  5

Glu Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  7

Glu Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro 
1               5                   10          


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  8

Glu Arg Lys Ser Ser Val Glu Ala Pro Pro Val Ala Gly 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  9

Glu Arg Lys Cys Ser Val Glu Ala Pro Pro Val Ala Gly 
1               5                   10              


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  10

Glu Ser Lys Tyr Gly Pro Pro Ala Pro Glu Phe Leu Gly Gly 
1               5                   10                  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  11

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  12

Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Pro Val Ala Gly 
1               5                   10                  15      


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  14

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  15

Glu Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  16

Glu Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  17

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  18

Glu Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  19
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  19

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  20
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  20

Glu Arg Lys Ser Ser Val Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Ala Pro Pro Val Ala Gly 
            20              


<210>  21
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  21

Glu Arg Lys Cys Ser Val Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Ala Pro Pro Val Ala Gly 
            20              


<210>  22
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  22

Glu Ser Lys Tyr Gly Pro Pro Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Ala Pro Glu Phe Leu Gly Gly 
            20                  


<210>  23
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  23

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Ala Pro Glu Leu Leu Gly Gly 
            20                  25          


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  24

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Ala Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Ala Lys Ala Pro Glu Phe Leu Gly Gly 
            20                  25                  


<210>  25
<211>  1072
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of construct MF1337xIgG4 UHxMF1122

<400>  25
ggcccagccg gccatggccg aggtgcagct ggtggagact ggggctgagg tgaagaagcc       60

gggggcctca gtgaaggtct cctgcaaggc ttctgactac atcttcacca aatatgacat      120

caactgggtg cgccaggccc ctggacaagg gcttgaatgg atgggatgga tgagcgctaa      180

cactggaaac acgggctatg cacagaagtt ccagggcaga gtcaccatga ccagggacac      240

gtccataaac acagcctaca tggagctgag cagcctgaca tctggtgaca cggccgttta      300

tttctgtgcg aggagtagtc ttttcaagac agagacggcg ccctactatc acttcgctct      360

ggacgtctgg ggccaaggga ccacggtcac cgtctccagt gctagcacca agggccccag      420

cgtgttcccc ctggccccct gcagccggag caccagcgag agcaccgccg ccctgggctg      480

cctggtgaag gactacttcc ccgagcccgt gaccgtgagc tggaacagcg gcgccctgac      540

cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgagcag      600

cgtggtgacg gtgcccagca gcagcctggg caccaagacc tacacctgca acgtggacca      660

caagcccagc aacaccaagg tggacaagcg ggtggagagc aagtacggcc cccccgaggt      720

gcagctggtg gagtctgggg gaggcgtggt ccagcctggg aggtccctga gactctcctg      780

tgcagcctct ggattcacct tcagtagcta tggcatgcac tgggtccgcc aggctccagg      840

caaggggctg gagtgggtgg cagttatatc atatgatgga agtaataaat actatgcaga      900

ctccgtgaag ggccgattca ccatctccag agacaattcc aagaacacgc tgtatctgca      960

aatgaacagc ctgagagctg aggacacggc cgtgtattac tgtgcaagag ccctcttcac     1020

gaccatcgcc atggactatt ggggccaagg tacccttgtc accgtctcga gt             1072


<210>  26
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of MF1122

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Phe Thr Thr Ile Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr 
        115     


<210>  27
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of MF1025

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Trp Trp Ala Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr 
        115 


<210>  28
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of MF1337

<400>  28

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Lys Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Ala Asn Thr Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr Ala Pro Tyr Tyr His Phe 
            100                 105                 110         


Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 


<210>  29
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of common light chain (cLC)

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  30
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  30

Cys Cys Thr Cys Ala Thr Gly Cys Ala Thr Cys Ala Cys Gly Gly Ala 
1               5                   10                  15      


Gly Cys Ala Thr Gly 
            20      


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  31

Cys Ala Ala Ala Gly Gly Cys Cys Ala Ala Ala Cys Thr Cys Thr Cys 
1               5                   10                  15      


Cys Ala Cys Thr Cys 
            20      


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  32

Cys Gly Cys Thr Gly Thr Gly Cys Cys Cys Cys Cys Ala Gly Ala Gly 
1               5                   10                  15      


Gly Thr Gly Cys 
            20  


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  33
gtaccggtga attggccgg                                                    19


<210>  34
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  34

Gly Cys Gly Cys Cys Cys Thr Ala Cys Thr Ala Thr Cys Ala Cys Thr 
1               5                   10                  15      


Thr Cys Gly Cys Thr Cys Thr Gly Gly 
            20                  25  


<210>  35
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Common light chain

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  36
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  common light chain variable domain (IGKV1-39/jk1)


<220>
<221>  CDS
<222>  (1)..(321)

<400>  36
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag agc att agc agc tac         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr           
            20                  25                  30                    

tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc        144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gct gca tcc agt ttg caa agt ggg gtc cca tca agg ttc agt ggc        192
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca act tac tac tgt caa cag agt tac agt acc cct cca        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro           
                85                  90                  95                

acg ttc ggc caa ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  37
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  38
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  common light chain constant region


<220>
<221>  CDS
<222>  (1)..(324)

<400>  38
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  39
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  40
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV1-39/jk5 common light chain variable domain

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  41
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-region IGKV1-39A

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  42
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  43
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  44
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  44

Cys Pro Pro Cys Pro 
1               5   


<210>  45
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Pro Glu Leu Leu Gly Gly 
1               5           


<210>  46
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  47
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  47

Glu Arg Lys Cys Cys Val Glu 
1               5           


<210>  48
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  48

Cys Pro Pro Cys Pro 
1               5   


<210>  49
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  49

Ala Pro Pro Val Ala Gly 
1               5       


<210>  50
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  50

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
    50                  55                  60                  


Glu Phe Leu Gly Gly 
65                  


<210>  51
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  51

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  52
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
1               5                   10                  15      


Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            20                  25                  30          


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        35                  40                  45              


Cys Pro 
    50  


<210>  53
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Pro Glu Phe Leu Gly Gly 
1               5           


<210>  54
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  54

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  55
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Ser Lys Tyr Gly Pro Pro 
1               5           


<210>  56
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  56

Cys Pro Ser Cys Pro 
1               5   


<210>  57
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  57

Ala Pro Glu Phe Leu Gly Gly 
1               5           


<210>  58
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val 
        35                  40                  45              


Val Gln Pro Gly 
    50          


<210>  59
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Val 
            20                  25                  30          


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45  


<210>  60
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Glu Val Gln Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Val Val Gln Pro Gly 
        35                  40  


<210>  61
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45      


<210>  62
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Ala Pro Glu Leu Leu Gly Gly Glu Val Gln Leu Val Glu 
        35                  40                  45              


Ser Gly Gly Gly Val Val Gln Pro Gly 
    50                  55          


<210>  63
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45          


<210>  64
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  64

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
            20                  25                  30          


Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45              


<210>  65
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40          


<210>  66
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  66

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Ser Ser Val Glu Ala Pro Pro Val Ala Gly Glu Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40              


<210>  67
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  67

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
            20                  25                  30          


Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45              


<210>  68
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  68

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40          


<210>  69
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  69

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Cys Ser Val Glu Ala Pro Pro Val Ala Gly Glu Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40              


<210>  70
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  70

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Pro Val Ala Gly Glu 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45      


<210>  71
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  71

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Val Val Gln Pro Gly 
        35                  40  


<210>  72
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  72

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Ser Ser Val Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30          


Ala Pro Pro Val Ala Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        35                  40                  45              


Val Val Gln Pro Gly 
    50              


<210>  73
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  73

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Cys Ser Val Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30          


Ala Pro Pro Val Ala Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        35                  40                  45              


Val Val Gln Pro Gly 
    50              


<210>  74
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  74

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Ala Pro Glu Phe Leu 
            20                  25                  30          


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
        35                  40                  45              


Gly 
    


<210>  75
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  75

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40          


<210>  76
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  76

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Ala Ala Ala Lys 
            20                  25                  30          


Glu Ala Ala Ala Lys Ala Pro Glu Phe Leu Gly Gly Glu Val Gln Leu 
        35                  40                  45              


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
    50                  55                  


<210>  77
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  77

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro Ala Pro Glu Phe Leu 
            20                  25                  30          


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
        35                  40                  45              


Gly 
    


<210>  78
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  78

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40          


<210>  79
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  79

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Ala Pro Glu Phe Leu Gly Gly Glu Val Gln 
            20                  25                  30          


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  


<210>  80
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  80

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly 
        35          


<210>  81
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  81

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30          


Ala Pro Glu Phe Leu Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
        35                  40                  45              


Gly Val Val Gln Pro Gly 
    50                  


<210>  82
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  82

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met 
    50          


<210>  83
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF6744

<400>  83
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc actgaaaatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctttcctg atgactctga taccagatac      180

agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag taccgcctac      240

ctgcagtgga gcagcctgaa accctcggac accgccatgt attactgtgt gagacttggt      300

ggatatagtg gctacgctga ggattttgtt gacttctggg gccagggaac cctggtcacc      360

gtctccagt                                                              369


<210>  84
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF6744 FW1

<400>  84

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            20                  25                  30  


<210>  85
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF6744 FW2

<400>  85

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  86
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF6744 FW3

<400>  86

Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Pro Ser Asp Thr Ala Met Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  87
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   FW4

<400>  87

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF6744 CDR1

<400>  88

Ser Tyr Trp Ile Gly 
1               5   


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF6744 CDR2

<400>  89

Ile Ile Phe Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF6744 CDR3

<400>  90

Leu Gly Gly Tyr Ser Gly Tyr Ala Glu Asp Phe Val Asp Phe 
1               5                   10                  


<210>  91
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF6744 VH

<400>  91

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Phe Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Leu Gly Gly Tyr Ser Gly Tyr Ala Glu Asp Phe Val Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  92
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF8057

<400>  92
gaggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttccgc agctttggta tcagttgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggagga ttcatccctg tccttggtac agcaaactac      180

gcacagaaat tccagggcag agtgacgatt atcgcggaca aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gcgaaggggt      300

aactggaacc cgttcgaccc ctggggccag ggaaccctgg tcaccgtctc gagt            354


<210>  93
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8057 FW1

<400>  93

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg 
            20                  25                  30  


<210>  94
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8057 FW2

<400>  94

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  95
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8057 FW3

<400>  95

Arg Val Thr Ile Ile Ala Asp Lys Ser Thr Asn Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8057 FW4

<400>  96

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  97
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8057 CDR1

<400>  97

Ser Phe Gly Ile Ser 
1               5   


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8057 CDR2

<400>  98

Gly Phe Ile Pro Val Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8057 CDR3

<400>  99

Arg Gly Asn Trp Asn Pro Phe Asp Pro 
1               5                   


<210>  100
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8057 VH

<400>  100

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Val Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ile Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asn Trp Asn Pro Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  101
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF8058

<400>  101
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggaga cgccttcaaa agcaaaacct ttactatcag ctgggtgcga      120

caggcccctg gacaggggct tgagtggctg ggggggatca tccctctttt tggtacaatt      180

acctacgcac agaagttcca gggcagagtc acgattaccg cggacaaatc cacgaacact      240

gccttcatgg aactgagcag cctgagatct gaggacacgg ccatgtatta ttgtacgcga      300

cgggggaact ggaacccctt cgacccctgg ggccagggaa ccctggtcac cgtctcgagt      360


<210>  102
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8058 FW1

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Ala Phe Lys 
            20                  25                  30  


<210>  103
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8058 FW2

<400>  103

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  104
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8058 FW3

<400>  104

Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Phe Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8058 FW4

<400>  105

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8058 CDR1

<400>  106

Ser Lys Thr Phe Thr Ile Ser 
1               5           


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8058 CDR2

<400>  107

Gly Ile Ile Pro Leu Phe Gly Thr Ile Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8058 CDR3

<400>  108

Arg Gly Asn Trp Asn Pro Phe Asp Pro 
1               5                   


<210>  109
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8058 VH

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Ala Phe Lys Ser Lys 
            20                  25                  30          


Thr Phe Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Gly Ile Ile Pro Leu Phe Gly Thr Ile Thr Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr 
65                  70                  75                  80  


Ala Phe Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Arg Gly Asn Trp Asn Pro Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  110
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF8078

<400>  110
gaggtgcagc tggtgcagtc tgggtctgag ttgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagt caccttcaac agcagaacct ttactatcag ttgggtgcga      120

caggcccctg gacaagggct tgagtggctg gggagtatca tccctatttt tggtacaata      180

acctacgcac agaagttcca gggcagagtc acgattaccg cggacaaatc cacgagcact      240

gccttcatgg aactgaccag cctgagatct gaggacacgg ccatatatta ttgtacgaga      300

cgggggaact ggaacccctt cgacccctgg ggccagggca ccctggtcac cgtctcgagt      360


<210>  111
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8078 FW1

<400>  111

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Thr Phe Asn 
            20                  25                  30  


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8078 FW2

<400>  112

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  113
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8078 FW3

<400>  113

Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Phe Met Glu 
1               5                   10                  15      


Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8078 FW4

<400>  114

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8078 CDR1

<400>  115

Ser Arg Thr Phe Thr Ile Ser 
1               5           


<210>  116
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8078 CDR2

<400>  116

Ser Ile Ile Pro Ile Phe Gly Thr Ile Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8078 CDR3

<400>  117

Arg Gly Asn Trp Asn Pro Phe Asp Pro 
1               5                   


<210>  118
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8078 VH

<400>  118

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Thr Phe Asn Ser Arg 
            20                  25                  30          


Thr Phe Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Ser Ile Ile Pro Ile Phe Gly Thr Ile Thr Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr 
65                  70                  75                  80  


Ala Phe Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Arg Gly Asn Trp Asn Pro Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  119
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF8397

<400>  119
caggtgcagc tggtgcagtc tgggggaggc ctggtacagc ctggggggtc cctgagactc       60

tcctgtgcaa cctctggatt caaattcagt agctatgccc tgagctgggt ccgccaggca      120

ccagggaagg gactggagtg ggtctcaggt attagtggta gtggtcgcac cacatggtat      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagagacggt      300

ggatacagct atggccctta ctggtacttc gatctctggg gccgtggaac cctggtcacc      360

gtctccagt                                                              369


<210>  120
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8397 FW1

<400>  120

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Lys Phe Ser 
            20                  25                  30  


<210>  121
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8397 FW2

<400>  121

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  122
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8397 FW3

<400>  122

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8397 FW4

<400>  123

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8397 CDR1

<400>  124

Ser Tyr Ala Leu Ser 
1               5   


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8397 CDR2

<400>  125

Gly Ile Ser Gly Ser Gly Arg Thr Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8397 CDR3

<400>  126

Asp Gly Gly Tyr Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  127
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8397 VH

<400>  127

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Lys Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Arg Thr Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Tyr Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  128
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF8508

<400>  128
gaggtgcagc tggtggagtc tgggggagga ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcaa cctctggatt caactttgat gattatacca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcagat attagttgga gtagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtgg      240

ctgcaaatga acagtctgag aactgaggac acggccttgt atttctgtgc aaaagatcat      300

agggggtacg gtgactacga gggtggtggc tttgactact ggggccaggg aaccctggtc      360

accgtctcca gt                                                          372


<210>  129
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8508 FW1

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Asn Phe Asp 
            20                  25                  30  


<210>  130
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8508 FW2

<400>  130

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  131
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8508 FW3

<400>  131

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Trp Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Phe Cys Ala Lys 
            20                  25                  30          


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8508 FW4

<400>  132

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  133
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8508 CDR1

<400>  133

Asp Tyr Thr Met His 
1               5   


<210>  134
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8508 CDR2

<400>  134

Asp Ile Ser Trp Ser Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8508 CDR3

<400>  135

Asp His Arg Gly Tyr Gly Asp Tyr Glu Gly Gly Gly Phe Asp Tyr 
1               5                   10                  15  


<210>  136
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8508 VH

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Asn Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Trp Ser Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Trp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp His Arg Gly Tyr Gly Asp Tyr Glu Gly Gly Gly Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  137
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF9249

<400>  137
gaggtgcagc tggtgcagtc tggagcagaa gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttact aggttttgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccaccag taccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accggcatgt attattgtgt gagacatata      300

cgatattttg actggtcgga agactaccac tattacctgg acgtctgggg caaagggacc      360

acggtcaccg tctccagt                                                    378


<210>  138
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9249 FW1

<400>  138

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            20                  25                  30  


<210>  139
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9249 FW2

<400>  139

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  140
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9249 FW3

<400>  140

Gln Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Gly Met Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9249 FW4

<400>  141

Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9249 CDR1

<400>  142

Arg Phe Trp Ile Gly 
1               5   


<210>  143
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9249 CDR2

<400>  143

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  144
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9249 CDR3

<400>  144

His Ile Arg Tyr Phe Asp Trp Ser Glu Asp Tyr His Tyr Tyr Leu Asp 
1               5                   10                  15      


Val 
    


<210>  145
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9249 VH

<400>  145

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Arg Phe 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Gly Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Ile Arg Tyr Phe Asp Trp Ser Glu Asp Tyr His Tyr Tyr 
            100                 105                 110         


Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  146
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF9267

<400>  146
gaggtgcagc tggtggagtc tggggcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttact aggtattgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag tactgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attattgtgt gagaaatata      300

cgatattttg tctggtcgga ggactaccac tactacatgg acgtctgggg caaagggacc      360

acggtcaccg tctccagt                                                    378


<210>  147
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9267 FW1

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
            20                  25                  30  


<210>  148
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9267 FW2

<400>  148

Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  149
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9267 FW3

<400>  149

Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9267 FW4

<400>  150

Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  151
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9267 CDR1

<400>  151

Arg Tyr Trp Ile Gly 
1               5   


<210>  152
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9267 CDR2

<400>  152

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  153
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9267 CDR3

<400>  153

Asn Ile Arg Tyr Phe Val Trp Ser Glu Asp Tyr His Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  154
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9267 VH

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Arg Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asn Ile Arg Tyr Phe Val Trp Ser Glu Asp Tyr His Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  155
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5377

<400>  155
gaggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg catcttcagc acctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttgatac accaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggacctga gcagcctgag atctgaggac acggccgtat attactgtgc gaaaaacgtg      300

cgtggatata gtgcctacga ccttgactac tggggccagg gcaccctggt caccgtctcc      360

agt                                                                    363


<210>  156
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5377 FW1

<400>  156

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser 
            20                  25                  30  


<210>  157
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5377 FW2

<400>  157

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  158
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5377 FW3

<400>  158

Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Asp 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  159
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5377 FW4

<400>  159

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  160
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5377 CDR1

<400>  160

Thr Tyr Ala Ile Ser 
1               5   


<210>  161
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5377 CDR2

<400>  161

Gly Ile Ile Pro Ile Phe Asp Thr Pro Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  162
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5377 CDR3

<400>  162

Asn Val Arg Gly Tyr Ser Ala Tyr Asp Leu Asp Tyr 
1               5                   10          


<210>  163
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5377 VH

<400>  163

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Val Arg Gly Tyr Ser Ala Tyr Asp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  164
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5444

<400>  164
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctattcta tgaattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacacca acactgggaa cccaacgtat      180

gcccagggct tcacaggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaggac actgccgtgt attactgtgc gagagatcac      300

gattttcgga ctgggagggc ttttgatatc tggggccaag ggaccacggt caccgtctcc      360

agt                                                                    363


<210>  165
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5444 FW1

<400>  165

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  166
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5444 FW2

<400>  166

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  167
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5444 FW3

<400>  167

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  168
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5444 FW4

<400>  168

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  169
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5444 CDR1

<400>  169

Ser Tyr Ser Met Asn 
1               5   


<210>  170
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5444 CDR2

<400>  170

Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  171
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5444 CDR3

<400>  171

Asp His Asp Phe Arg Thr Gly Arg Ala Phe Asp Ile 
1               5                   10          


<210>  172
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5444 VH

<400>  172

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Asp Phe Arg Thr Gly Arg Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  173
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5380

<400>  173
gaggtgcagc tggtggagtc tgggggagac gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca actccaagag cacgctgttt      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt atttctgtgt gagaggcctc      300

cccataacta tggttcgggg agcgtactcc tttgactact ggggccaggg caccctggtc      360

accgtctcca gt                                                          372


<210>  174
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5380 FW1

<400>  174

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  175
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5380 FW2

<400>  175

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  176
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5380 FW3

<400>  176

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Phe Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Val Arg 
            20                  25                  30          


<210>  177
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5380 FW4

<400>  177

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  178
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5380 CDR1

<400>  178

Ser Tyr Gly Met His 
1               5   


<210>  179
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5380 CDR2

<400>  179

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  180
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5380 CDR3

<400>  180

Gly Leu Pro Ile Thr Met Val Arg Gly Ala Tyr Ser Phe Asp Tyr 
1               5                   10                  15  


<210>  181
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF5380 VH

<400>  181

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Gly Leu Pro Ile Thr Met Val Arg Gly Ala Tyr Ser Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  182
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF8233

<400>  182
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatgccaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggctgtgt attactgtgc aaaagatcgt      300

cattggcatt ggtggctgga cgcctttgat tattggggcc aaggtaccct ggtcaccgtc      360

tccagt                                                                 366


<210>  183
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8233 FW1

<400>  183

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  184
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8233 FW2

<400>  184

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  185
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8233 FW3

<400>  185

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8233 FW4

<400>  186

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  187
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8233 CDR1

<400>  187

Ser Tyr Gly Ile Ser 
1               5   


<210>  188
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8233 CDR2

<400>  188

Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  189
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8233 CDR3

<400>  189

Asp Arg His Trp His Trp Trp Leu Asp Ala Phe Asp Tyr 
1               5                   10              


<210>  190
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF8233 VH

<400>  190

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg His Trp His Trp Trp Leu Asp Ala Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  191
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF9891

<400>  191
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatgccaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggctgtgt attactgtgc aaaagatctg      300

tacggtcatt ggtggctgga tgcctttgat tattggggcc aaggtaccct ggtcaccgtc      360

tccagt                                                                 366


<210>  192
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9891 FW1

<400>  192

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  193
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9891 FW2

<400>  193

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  194
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9891 FW3

<400>  194

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  195
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9891 FW4

<400>  195

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  196
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9891 CDR1

<400>  196

Ser Tyr Gly Ile Ser 
1               5   


<210>  197
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9891 CDR2

<400>  197

Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  198
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9891 CDR3

<400>  198

Asp Leu Tyr Gly His Trp Trp Leu Asp Ala Phe Asp Tyr 
1               5                   10              


<210>  199
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9891 VH

<400>  199

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Tyr Gly His Trp Trp Leu Asp Ala Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  200
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF9886

<400>  200
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatgccaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggctgtgt attactgtgc aaaaggtcca      300

ggttctcatt ggtggctgga tgcctttgat tattggggcc aaggtaccct ggtcaccgtc      360

tccagt                                                                 366


<210>  201
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9886 FW1

<400>  201

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  202
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9886 FW2

<400>  202

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  203
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9886 FW3

<400>  203

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  204
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9886 FW4

<400>  204

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  205
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9886 CDR1

<400>  205

Ser Tyr Gly Ile Ser 
1               5   


<210>  206
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9886 CDR2

<400>  206

Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  207
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9886 CDR3

<400>  207

Gly Pro Gly Ser His Trp Trp Leu Asp Ala Phe Asp Tyr 
1               5                   10              


<210>  208
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9886 VH

<400>  208

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Gly Ser His Trp Trp Leu Asp Ala Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  209
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF9873

<400>  209
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatgccaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggctgtgt attactgtgc aaaagataga      300

ggttggcatt ggtggctgga tgcctttgat tattggggcc aaggtaccct ggtcaccgtc      360

tccagt                                                                 366


<210>  210
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9873 FW1

<400>  210

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  211
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9873 FW2

<400>  211

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  212
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9873 FW3

<400>  212

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  213
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9873 FW4

<400>  213

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  214
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9873 CDR1

<400>  214

Ser Tyr Gly Ile Ser 
1               5   


<210>  215
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9873 CDR2

<400>  215

Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  216
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9873 CDR3

<400>  216

Asp Arg Gly Trp His Trp Trp Leu Asp Ala Phe Asp Tyr 
1               5                   10              


<210>  217
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9873 VH

<400>  217

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Gly Trp His Trp Trp Leu Asp Ala Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  218
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF9988

<400>  218
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatgccaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggctgtgt attactgtgc aaaagatcgt      300

cattggcatt ggtggctgga cggctttgat tattggggcc aaggtaccct ggtcaccgtc      360

tcgagtgtct ccagt                                                       375


<210>  219
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9988 FW1

<400>  219

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  220
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9988 FW2

<400>  220

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  221
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9988 FW3

<400>  221

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  222
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9988 FW4

<400>  222

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  223
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9988 CDR1

<400>  223

Ser Tyr Gly Ile Ser 
1               5   


<210>  224
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9988 CDR2

<400>  224

Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  225
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9988 CDR3

<400>  225

Asp Arg His Trp His Trp Trp Leu Asp Gly Phe Asp Tyr 
1               5                   10              


<210>  226
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF9988 VH

<400>  226

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Ala Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg His Trp His Trp Trp Leu Asp Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  227
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF1337

<400>  227
gaggtgcagc tggtggagac tggggctgag gtgaagaagc cgggggcctc agtgaaggtc       60

tcctgcaagg cttctgacta catcttcacc aaatatgaca tcaactgggt gcgccaggcc      120

cctggacaag ggcttgaatg gatgggatgg atgagcgcta acactggaaa cacgggctat      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccataaa cacagcctac      240

atggagctga gcagcctgac atctggtgac acggccgttt atttctgtgc gaggagtagt      300

cttttcaaga cagagacggc gccctactat cacttcgctc tggacgtctg gggccaaggg      360

accacggtca ccgtctccag t                                                381


<210>  228
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1337 FW1

<400>  228

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr 
            20                  25                  30  


<210>  229
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1337 FW2

<400>  229

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  230
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1337 FW3

<400>  230

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  231
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1337 FW4

<400>  231

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  232
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  232

Lys Tyr Asp Ile Asn 
1               5   


<210>  233
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1337 CDR2

<400>  233

Trp Met Ser Ala Asn Thr Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  234
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1337 CDR3

<400>  234

Ser Ser Leu Phe Lys Thr Glu Thr Ala Pro Tyr Tyr His Phe Ala Leu 
1               5                   10                  15      


Asp Val 
        


<210>  235
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1337 VH

<400>  235

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Lys Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Ala Asn Thr Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr Ala Pro Tyr Tyr His Phe 
            100                 105                 110         


Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  236
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF1122

<400>  236
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggccgtgt attactgtgc aagagccctc      300

ttcacgacca tcgccatgga ctattggggc caaggtaccc tggtcaccgt ctccagt         357


<210>  237
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1122 FW1

<400>  237

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  238
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1122 FW2

<400>  238

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  239
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1122 FW3

<400>  239

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  240
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1122 FW4

<400>  240

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  241
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1122 CDR1

<400>  241

Ser Tyr Gly Met His 
1               5   


<210>  242
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1122 CDR2

<400>  242

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  243
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1122 CDR3

<400>  243

Ala Leu Phe Thr Thr Ile Ala Met Asp Tyr 
1               5                   10  


<210>  244
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1122 VH

<400>  244

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Phe Thr Thr Ile Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  245
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF1025

<400>  245
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc aagggccgat      300

tggtgggcga cttttgacta ctggggccaa ggtaccctgg tcaccgtctc cagt            354


<210>  246
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1025 FW1

<400>  246

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  247
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1025 FW2

<400>  247

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  248
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1025 FW3

<400>  248

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  249
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1025 FW4

<400>  249

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  250
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1025 CDR1

<400>  250

Ser Tyr Ala Met Ser 
1               5   


<210>  251
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1025 CDR2

<400>  251

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  252
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1025 CDR3

<400>  252

Ala Asp Trp Trp Ala Thr Phe Asp Tyr 
1               5                   


<210>  253
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1025 VH

<400>  253

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Trp Trp Ala Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  254
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR1

<400>  254

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  255
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR2

<400>  255

Ala Ala Ser 
1           


<210>  256
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR3

<400>  256

Gln Gln Ser Tyr Ser Thr Pro 
1               5           


<210>  257
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  258
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  259
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG1H

<400>  259

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Glu Val Gln Leu 
        115                 120                 


<210>  260
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG1MH

<400>  260

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser 
            100                 105                 110         


Pro Glu Val Gln Leu 
        115         


<210>  261
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG1 UH

<400>  261

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Glu Val Gln Leu 
            100                 105                 110         


<210>  262
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG1G4S

<400>  262

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Val Gln Leu 
        115             


<210>  263
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG1UL

<400>  263

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ala Pro Glu Leu 
            100                 105                 110         


Leu Gly Gly Glu Val Gln Leu 
        115                 


<210>  264
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG1R

<400>  264

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Glu Ala Ala Ala 
            100                 105                 110         


Lys Glu Ala Ala Ala Lys Ala Pro Glu Leu Leu Gly Gly Glu Val Gln 
        115                 120                 125             


Leu 
    


<210>  265
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG2AH

<400>  265

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Glu Val Gln Leu 
        115                 120 


<210>  266
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of Ig G2AMH

<400>  266

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro Glu Val 
            100                 105                 110         


Gln Leu 
        


<210>  267
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG2AUL

<400>  267

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Ser Ser Val Glu Ala Pro Pro Val Ala Gly Glu 
            100                 105                 110         


Val Gln Leu 
        115 


<210>  268
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG2AG4SS

<400>  268

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
            100                 105                 110         


<210>  269
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG2AG4SL

<400>  269

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Pro Val 
            100                 105                 110         


Ala Gly Glu Val Gln Leu 
        115             


<210>  270
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG2AR

<400>  270

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Ser Ser Val Glu Glu Ala Ala Ala Lys Glu Ala 
            100                 105                 110         


Ala Ala Lys Ala Pro Pro Val Ala Gly Glu Val Gln Leu 
        115                 120                 125 


<210>  271
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG2BH

<400>  271

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Glu Val Gln Leu 
        115                 120 


<210>  272
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG2BMH

<400>  272

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro Glu Val 
            100                 105                 110         


Gln Leu 
        


<210>  273
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG2BUL

<400>  273

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Ser Val Glu Ala Pro Pro Val Ala Gly Glu 
            100                 105                 110         


Val Gln Leu 
        115 


<210>  274
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG2BR

<400>  274

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Ser Val Glu Glu Ala Ala Ala Lys Glu Ala 
            100                 105                 110         


Ala Ala Lys Ala Pro Pro Val Ala Gly Glu Val Gln Leu 
        115                 120                 125 


<210>  275
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG3ULH

<400>  275

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Glu Val Gln Leu 
        115                 120     


<210>  276
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG3UH

<400>  276

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Val 
            100                 105                 110         


Gln Leu 
        


<210>  277
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG3R

<400>  277

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Ala 
            100                 105                 110         


Ala Ala Lys Glu Ala Ala Ala Lys Ala Pro Glu Phe Leu Gly Gly Glu 
        115                 120                 125             


Val Gln Leu 
    130     


<210>  278
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG4H

<400>  278

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Glu Val Gln Leu 
        115                 120     


<210>  279
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG4UH

<400>  279

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Glu Val Gln Leu 
            100                 105                 


<210>  280
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG4MH

<400>  280

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro Glu Val 
            100                 105                 110         


Gln Leu 
        


<210>  281
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG4R

<400>  281

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Glu Ala Ala Ala Lys Glu Ala 
            100                 105                 110         


Ala Ala Lys Ala Pro Glu Phe Leu Gly Gly Glu Val Gln Leu 
        115                 120                 125     


<210>  282
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of IgG4UL

<400>  282

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Ala Pro Glu Phe Leu Gly Gly 
            100                 105                 110         


Glu Val Gln Leu 
        115     


<210>  283
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus

<400>  283

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Lys Ser Thr Ser Glu Val Gln Leu 
            100                 105         


<210>  284
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of construct MF1337xIgG4 UHxMF1122


<220>
<221>  CDS
<222>  (1)..(1053)

<400>  284
gag gtg cag ctg gtg gag act ggg gct gag gtg aag aag ccg ggg gcc         48
Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc aag gct tct gac tac atc ttc acc aaa tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Lys Tyr           
            20                  25                  30                    

gac atc aac tgg gtg cgc cag gcc cct gga caa ggg ctt gaa tgg atg        144
Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atg agc gct aac act gga aac acg ggc tat gca cag aag ttc        192
Gly Trp Met Ser Ala Asn Thr Gly Asn Thr Gly Tyr Ala Gln Lys Phe           
    50                  55                  60                            

cag ggc aga gtc acc atg acc agg gac acg tcc ata aac aca gcc tac        240
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg agc agc ctg aca tct ggt gac acg gcc gtt tat ttc tgt        288
Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg agg agt agt ctt ttc aag aca gag acg gcg ccc tac tat cac ttc        336
Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr Ala Pro Tyr Tyr His Phe           
            100                 105                 110                   

gct ctg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc agt gct        384
Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala           
        115                 120                 125                       

agc acc aag ggc ccc agc gtg ttc ccc ctg gcc ccc tgc agc cgg agc        432
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser           
    130                 135                 140                           

acc agc gag agc acc gcc gcc ctg ggc tgc ctg gtg aag gac tac ttc        480
Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe           
145                 150                 155                 160           

ccc gag ccc gtg acc gtg agc tgg aac agc ggc gcc ctg acc agc ggc        528
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly           
                165                 170                 175               

gtg cac acc ttc ccc gcc gtg ctg cag agc agc ggc ctg tac agc ctg        576
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu           
            180                 185                 190                   

agc agc gtg gtg acg gtg ccc agc agc agc ctg ggc acc aag acc tac        624
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr           
        195                 200                 205                       

acc tgc aac gtg gac cac aag ccc agc aac acc aag gtg gac aag cgg        672
Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg           
    210                 215                 220                           

gtg gag agc aag tac ggc ccc ccc gag gtg cag ctg gtg gag tct ggg        720
Val Glu Ser Lys Tyr Gly Pro Pro Glu Val Gln Leu Val Glu Ser Gly           
225                 230                 235                 240           

gga ggc gtg gtc cag cct ggg agg tcc ctg aga ctc tcc tgt gca gcc        768
Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala           
                245                 250                 255               

tct gga ttc acc ttc agt agc tat ggc atg cac tgg gtc cgc cag gct        816
Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala           
            260                 265                 270                   

cca ggc aag ggg ctg gag tgg gtg gca gtt ata tca tat gat gga agt        864
Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser           
        275                 280                 285                       

aat aaa tac tat gca gac tcc gtg aag ggc cga ttc acc atc tcc aga        912
Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg           
    290                 295                 300                           

gac aat tcc aag aac acg ctg tat ctg caa atg aac agc ctg aga gct        960
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala           
305                 310                 315                 320           

gag gac acg gcc gtg tat tac tgt gca aga gcc ctc ttc acg acc atc       1008
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Phe Thr Thr Ile           
                325                 330                 335               

gcc atg gac tat tgg ggc caa ggt acc ctt gtc acc gtc tcg agt           1053
Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser               
            340                 345                 350                   


<210>  285
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  285

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Lys Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Ala Asn Thr Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr Ala Pro Tyr Tyr His Phe 
            100                 105                 110         


Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
    130                 135                 140                 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
        195                 200                 205             


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Ser Lys Tyr Gly Pro Pro Glu Val Gln Leu Val Glu Ser Gly 
225                 230                 235                 240 


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
                245                 250                 255     


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser 
        275                 280                 285             


Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    290                 295                 300                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
305                 310                 315                 320 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Phe Thr Thr Ile 
                325                 330                 335     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            340                 345                 350     


<210>  286
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of MF1122

<400>  286

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Phe Thr Thr Ile Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  287
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of MF1025

<400>  287

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Trp Trp Ala Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  288
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation of MF1337

<400>  288

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Lys Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Ala Asn Thr Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr Ala Pro Tyr Tyr His Phe 
            100                 105                 110         


Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  289
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Met Asp Ser Asn Tyr 
            100                 105                 110         


Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro Asp Ile 
        115                 120                 125             


Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser 
    130                 135                 140                 


Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val 
145                 150                 155                 160 


Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu 
                165                 170                 175     


Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser 
            180                 185                 190         


Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile 
        195                 200                 205             


Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys 
    210                 215                 220                 


Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  290
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Arg Ile Arg Leu Leu Cys Cys Val Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Ile Ala Gly Ile Thr Gln Ala Pro Thr Ser Gln Ile Leu 
            20                  25                  30          


Ala Ala Gly Arg Arg Met Thr Leu Arg Cys Thr Gln Asp Met Arg His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Arg Gln Asp Leu Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Asn Thr Ala Gly Thr Thr Gly Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Ala Asn Thr Asp Asp Phe Pro Leu Thr 
                85                  90                  95      


Leu Ala Ser Ala Val Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Glu Ala Gly Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Phe 
305                 310 


<210>  291
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CH1


<220>
<221>  CDS
<222>  (1)..(294)

<400>  291
gct agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtc gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt                                                                294
Arg Val                                                                   
                                                                          


<210>  292
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  292

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  293
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-hinge


<220>
<221>  CDS
<222>  (1)..(45)

<400>  293
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca             45
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro               
1               5                   10                  15                


<210>  294
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  294

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  295
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CH2


<220>
<221>  CDS
<222>  (1)..(330)

<400>  295
gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa         48
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys           
1               5                   10                  15                

ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg         96
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val           
            20                  25                  30                    

gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac        144
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr           
        35                  40                  45                        

gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag        192
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu           
    50                  55                  60                            

cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac        240
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His           
65                  70                  75                  80            

cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa        288
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys           
                85                  90                  95                

gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa                330
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys                   
            100                 105                 110                   


<210>  296
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  296

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  297
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CH2 L235G G236R


<220>
<221>  CDS
<222>  (1)..(330)

<400>  297
gca cct gaa ctc ggc agg gga ccg tca gtc ttc ctc ttc ccc cca aaa         48
Ala Pro Glu Leu Gly Arg Gly Pro Ser Val Phe Leu Phe Pro Pro Lys           
1               5                   10                  15                

ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg         96
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val           
            20                  25                  30                    

gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac        144
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr           
        35                  40                  45                        

gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag        192
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu           
    50                  55                  60                            

cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac        240
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His           
65                  70                  75                  80            

cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa        288
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys           
                85                  90                  95                

gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa                330
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys                   
            100                 105                 110                   


<210>  298
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  298

Ala Pro Glu Leu Gly Arg Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  299
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CH3


<220>
<221>  CDS
<222>  (1)..(321)

<400>  299
ggg cag ccc cga gaa cca cag gtg tac acc aag ccc cca tcc cgg gag         48
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu           
1               5                   10                  15                

gag atg acc aag aac cag gtc agc ctg aag tgc ctg gtc aaa ggc ttc         96
Glu Met Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe           
            20                  25                  30                    

tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag        144
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu           
        35                  40                  45                        

aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc        192
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe           
    50                  55                  60                            

ttc ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg        240
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly           
65                  70                  75                  80            

aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac        288
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr           
                85                  90                  95                

acg cag aag agc ctc tcc ctg tct ccg ggt tga                            321
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly                                   
            100                 105                                       


<210>  300
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  300

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  301
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CH3


<220>
<221>  CDS
<222>  (1)..(321)

<400>  301
ggg cag ccc cga gaa cca cag gtg tac acc gac ccc cca tcc cgg gag         48
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Glu           
1               5                   10                  15                

gag atg acc aag aac cag gtc agc ctg acc tgc gag gtc aaa ggc ttc         96
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Glu Val Lys Gly Phe           
            20                  25                  30                    

tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag        144
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu           
        35                  40                  45                        

aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc        192
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe           
    50                  55                  60                            

ttc ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg        240
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly           
65                  70                  75                  80            

aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac        288
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr           
                85                  90                  95                

acg cag aag agc ctc tcc ctg tct ccg ggt tga                            321
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly                                   
            100                 105                                       


<210>  302
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  302

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Glu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


