                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       Hadasit Medical Research Services and Development Ltd.
       KOLODKIN-GAL, Ilana
       KEREN-PAZ, Alona
       KEREM, Eithan
       ZAMIR, Gideon
       KOLODKIN-GAL, Dror
       COHEN-CYMBERKNOH, Malena
 
<120>  METHODS OF DISRUPTING A BIOFILM AND/OR PREVENTING FORMATION OF 
       SAME

<130>  76658

<150>  IL 258467
<151>  2018-03-29

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
tcctgagcct gttgcttaac ccggtc                                            26


<210>  2
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
caattcgccc tatagtgagt cgttccgctc gtccactccc ctgctc                      46


<210>  3
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
ccagcttttg ttccctttag tgagattcat atgatataat cttaggggta atagcg           56


<210>  4
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
cctagtaaga ccgtctgtaa acaatacgc                                         29


<210>  5
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  5
atgctagtcg gttatacggg atg                                               23


<210>  6
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  6
caattcgccc tatagtgagt cgttcggatg tacctcctag aaataaactc g                51


<210>  7
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  7
ccagcttttg ttccctttag tgagggatac cgttcttaaa aaaccaggg                   49


<210>  8
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
gatcggttag gttttcttgt tcca                                              24


<210>  9
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
cgctttaatt tcgggatgct cgagga                                            26


<210>  10
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
caattcgccc tatagtgagt cgtataaaaa actccttctt gaatctttac g                51


<210>  11
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  11
ccagcttttg ttccctttag tgagcgttta caatagtgtt gagagtctat catcc            55


<210>  12
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  12
ctgatatttt ctttgaaacg ctcaccc                                           27


<210>  13
<211>  890
<212>  PRT
<213>  Bacillus subtilis

<400>  13

Met Lys Phe His Glu Met Gly Gln Thr Asp Leu Leu Glu Ala Thr Asn 
1               5                   10                  15      


Thr Ser Met Lys Gln Gly Leu Thr Glu Lys Glu Val Lys Lys Arg Leu 
            20                  25                  30          


Asp Lys His Gly Pro Asn Glu Leu Gln Glu Gly Lys Lys Thr Ser Ala 
        35                  40                  45              


Leu Leu Leu Phe Phe Ala Gln Phe Lys Asp Phe Met Val Leu Val Leu 
    50                  55                  60                  


Leu Ala Ala Thr Leu Ile Ser Gly Phe Leu Gly Glu Tyr Val Asp Ala 
65                  70                  75                  80  


Val Ala Ile Ile Ala Ile Val Phe Val Asn Gly Ile Leu Gly Phe Phe 
                85                  90                  95      


Gln Glu Arg Arg Ala Glu Gln Ser Leu Gln Ala Leu Lys Glu Leu Ser 
            100                 105                 110         


Thr Pro His Val Met Ala Leu Arg Glu Gly Ser Trp Thr Lys Ile Pro 
        115                 120                 125             


Ser Lys Glu Leu Val Pro Gly Asp Ile Val Lys Phe Thr Ser Gly Asp 
    130                 135                 140                 


Arg Ile Gly Ala Asp Val Arg Ile Val Glu Ala Arg Ser Leu Glu Ile 
145                 150                 155                 160 


Glu Glu Ser Ala Leu Thr Gly Glu Ser Ile Pro Val Val Lys His Ala 
                165                 170                 175     


Asp Lys Leu Lys Lys Pro Asp Val Ser Leu Gly Asp Ile Thr Asn Met 
            180                 185                 190         


Ala Phe Met Gly Thr Ile Val Thr Arg Gly Ser Gly Val Gly Val Val 
        195                 200                 205             


Val Gly Thr Gly Met Asn Thr Ala Met Gly Lys Ile Ala Asp Met Leu 
    210                 215                 220                 


Glu Ser Ala Gly Thr Leu Ser Thr Pro Leu Gln Arg Arg Leu Glu Gln 
225                 230                 235                 240 


Leu Gly Lys Ile Leu Ile Val Val Ala Leu Leu Leu Thr Val Leu Val 
                245                 250                 255     


Val Ala Val Gly Val Ile Gln Gly His Asp Leu Tyr Ser Met Phe Leu 
            260                 265                 270         


Ala Gly Val Ser Leu Ala Val Ala Ala Ile Pro Glu Gly Leu Pro Ala 
        275                 280                 285             


Ile Val Thr Val Ala Leu Ser Leu Gly Val Gln Arg Met Ile Lys Gln 
    290                 295                 300                 


Lys Ser Ile Val Arg Lys Leu Pro Ala Val Glu Thr Leu Gly Cys Ala 
305                 310                 315                 320 


Ser Ile Ile Cys Ser Asp Lys Thr Gly Thr Met Thr Gln Asn Lys Met 
                325                 330                 335     


Thr Val Thr His Val Trp Ser Gly Gly Lys Thr Trp Arg Val Ala Gly 
            340                 345                 350         


Ala Gly Tyr Glu Pro Lys Gly Ser Phe Thr Leu Asn Glu Lys Glu Ile 
        355                 360                 365             


Ser Val Asn Glu His Lys Pro Leu Gln Gln Met Leu Leu Phe Gly Ala 
    370                 375                 380                 


Leu Cys Asn Asn Ser Asn Ile Glu Lys Arg Asp Gly Glu Tyr Val Leu 
385                 390                 395                 400 


Asp Gly Asp Pro Thr Glu Gly Ala Leu Leu Thr Ala Ala Arg Lys Gly 
                405                 410                 415     


Gly Phe Ser Lys Glu Phe Val Glu Ser Asn Tyr Arg Val Ile Glu Glu 
            420                 425                 430         


Phe Pro Phe Asp Ser Ala Arg Lys Met Met Thr Val Ile Val Glu Asn 
        435                 440                 445             


Gln Asp Arg Lys Arg Tyr Ile Ile Thr Lys Gly Ala Pro Asp Val Leu 
    450                 455                 460                 


Met Gln Arg Ser Ser Arg Ile Tyr Tyr Asp Gly Ser Ala Ala Leu Phe 
465                 470                 475                 480 


Ser Asn Glu Arg Lys Ala Glu Thr Glu Ala Val Leu Arg His Leu Ala 
                485                 490                 495     


Ser Gln Ala Leu Arg Thr Ile Ala Val Ala Tyr Arg Pro Ile Lys Ala 
            500                 505                 510         


Gly Glu Thr Pro Ser Met Glu Gln Ala Glu Lys Asp Leu Thr Met Leu 
        515                 520                 525             


Gly Leu Ser Gly Ile Ile Asp Pro Pro Arg Pro Glu Val Arg Gln Ala 
    530                 535                 540                 


Ile Lys Glu Cys Arg Glu Ala Gly Ile Lys Thr Val Met Ile Thr Gly 
545                 550                 555                 560 


Asp His Val Glu Thr Ala Lys Ala Ile Ala Lys Asp Leu Arg Leu Leu 
                565                 570                 575     


Pro Lys Ser Gly Lys Ile Met Asp Gly Lys Met Leu Asn Glu Leu Ser 
            580                 585                 590         


Gln Glu Glu Leu Ser His Val Val Glu Asp Val Tyr Val Phe Ala Arg 
        595                 600                 605             


Val Ser Pro Glu His Lys Leu Lys Ile Val Lys Ala Tyr Gln Glu Asn 
    610                 615                 620                 


Gly His Ile Val Ala Met Thr Gly Asp Gly Val Asn Asp Ala Pro Ala 
625                 630                 635                 640 


Ile Lys Gln Ala Asp Ile Gly Val Ser Met Gly Ile Thr Gly Thr Asp 
                645                 650                 655     


Val Ala Lys Glu Ala Ser Ser Leu Val Leu Val Asp Asp Asn Phe Ala 
            660                 665                 670         


Thr Ile Lys Ser Ala Ile Lys Glu Gly Arg Asn Ile Tyr Glu Asn Ile 
        675                 680                 685             


Arg Lys Phe Ile Arg Tyr Leu Leu Ala Ser Asn Val Gly Glu Ile Leu 
    690                 695                 700                 


Val Met Leu Phe Ala Met Leu Leu Ala Leu Pro Leu Pro Leu Val Pro 
705                 710                 715                 720 


Ile Gln Ile Leu Trp Val Asn Leu Val Thr Asp Gly Leu Pro Ala Met 
                725                 730                 735     


Ala Leu Gly Met Asp Gln Pro Glu Gly Asp Val Met Lys Arg Lys Pro 
            740                 745                 750         


Arg His Pro Lys Glu Gly Val Phe Ala Arg Lys Leu Gly Trp Lys Val 
        755                 760                 765             


Val Ser Arg Gly Phe Leu Ile Gly Val Ala Thr Ile Leu Ala Phe Ile 
    770                 775                 780                 


Ile Val Tyr His Arg Asn Pro Glu Asn Leu Ala Tyr Ala Gln Thr Ile 
785                 790                 795                 800 


Ala Phe Ala Thr Leu Val Leu Ala Gln Leu Ile His Val Phe Asp Cys 
                805                 810                 815     


Arg Ser Glu Thr Ser Val Phe Ser Arg Asn Pro Phe Gln Asn Leu Tyr 
            820                 825                 830         


Leu Ile Gly Ala Val Leu Ser Ser Ile Leu Leu Met Leu Val Val Ile 
        835                 840                 845             


Tyr Tyr Pro Pro Leu Gln Pro Ile Phe His Thr Val Ala Ile Thr Pro 
    850                 855                 860                 


Gly Asp Trp Met Leu Val Ile Gly Met Ser Ala Ile Pro Thr Phe Leu 
865                 870                 875                 880 


Leu Ala Gly Ser Leu Leu Thr Arg Lys Lys 
                885                 890 


<210>  14
<211>  83
<212>  PRT
<213>  Bacillus subtilis

<400>  14

Met Thr Lys Asn Gln Asn Gln Tyr Gln Gln Pro Asn Pro Asp Asp Arg 
1               5                   10                  15      


Ser Asp Asn Val Glu Lys Leu Gln Asp Met Val Gln Asn Thr Ile Glu 
            20                  25                  30          


Asn Ile Glu Glu Ala Glu Ala Ser Met Glu Phe Ala Ser Gly Glu Asp 
        35                  40                  45              


Lys Gln Arg Ile Lys Glu Lys Asn Ala Arg Arg Glu Gln Ser Ile Glu 
    50                  55                  60                  


Ala Phe Arg Asn Glu Ile Gln Asp Glu Ser Ala Ala Arg Gln Asn Gly 
65                  70                  75                  80  


Tyr Arg Ser 
            


