                         SEQUENCE LISTING

<110>  GeneTether, Inc
 
<120>  MODIFIED NUCLEIC ACID EDITING SYSTEMS FOR TETHERING DONOR DNA

<130>  120838598

<150>  2018900990
<151>  2018-03-25

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  DNA
<213>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(14)
<223>  n is a, c, g, or t

<400>  1
cggnnnnnnn nnnnccg                                                      17


<210>  2
<211>  13
<212>  DNA
<213>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  w is a or t

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  n is a, t, g, or c

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  r is a or g

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  r is a, or g

<400>  2
watcaannnn ttr                                                          13


<210>  3
<211>  13
<212>  PRT
<213>  Synthetic

<400>  3

Trp Ala Thr Cys Ala Ala Asn Asn Asn Asn Thr Thr Arg 
1               5                   10              


<210>  4
<211>  14
<212>  PRT
<213>  Synthetic

<400>  4

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  5
<211>  12
<212>  PRT
<213>  Synthetic

<400>  5

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  6
<211>  18
<212>  PRT
<213>  Synthetic

<400>  6

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Glu 
        


<210>  7
<211>  36
<212>  PRT
<213>  Synthetic

<400>  7

Gly Gly Ser Ala Gly Gly Ser Gly Ser Gly Ser Ser Gly Gly Ser Ser 
1               5                   10                  15      


Gly Ala Ser Gly Thr Gly Thr Ala Gly Gly Thr Gly Ser Gly Ser Gly 
            20                  25                  30          


Thr Gly Ser Gly 
        35      


<210>  8
<211>  5411
<212>  DNA
<213>  Synthetic


<220>
<221>  localisation cosing sequence
<222>  (1)..(117)

<220>
<221>  GGS linker coding sequence
<222>  (118)..(126)

<220>
<221>  lacI domian coding sequence
<222>  (127)..(1209)

<220>
<221>  XTEN linker coding sequence
<222>  (1210)..(1257)

<220>
<221>  Cas9 wild type protein coding sequence
<222>  (1258)..(5361)

<400>  8
atggactaca aagaccatga cggtgattat aaagatcatg acatcgatta caaggatgac       60

gatgacaaga tggcccccaa gaagaagagg aaggtgggca ttcaccgcgg ggtacctgga      120

ggttctatga tgaagcccgt gaccctgtac gacgtggccg agtacgccgg cgtgagctac      180

cagaccgtga gccgcgtggt gaaccaggcc agccacgtga gcgccaagac ccgcgagaag      240

gtggaggccg ccatggccga gctgaactac atccccaacc gcgtggccca gcagctggcc      300

ggcaagcaga gcctgctgat cggcgtggcc accagcagcc tggccctgca cgcccccagc      360

cagatcgtgg ccgccatcaa gagccgcgcc gaccagctgg gcgccagcgt ggtggtgagc      420

atggtggagc gcagcggcgt ggaggcctgc aaggccgccg tgcacaacct gctggcccag      480

cgcgtgagcg gcctgatcat caactacccc ctggacgacc aggacgccat cgccgtggag      540

gccgcctgca ccaacgtgcc cgccctgttc ctggacgtga gcgaccagac ccccatcaac      600

agcatcatct tcagccacga ggacggcacc cgcctgggcg tggagcacct ggtggccctg      660

ggccaccagc agatcgccct gctggccggc cccctgagca gcgtgagcgc ccgcctgcgc      720

ctggccggct ggcacaagta cctgacccgc aaccagatcc agcccatcgc cgagcgcgag      780

ggcgactgga gcgccatgag cggcttccag cagaccatgc agatgctgaa cgagggcatc      840

gtgcccaccg ccatgctggt ggccaacgac cagatggccc tgggcgccat gcgcgccatc      900

accgagagcg gcctgcgcgt gggcgccgac atcagcgtgg tgggctacga cgacaccgag      960

gacagcagct gctacatccc ccccctgacc accatcaagc aggacttccg cctgctgggc     1020

cagaccagcg tggaccgcct gctgcagctg agccagggcc aggccgtgaa gggcaaccag     1080

ctgctgcccg tgagcctggt gaagcgcaag accaccctgg cccccaacac ccagaccgcc     1140

agcccccgcg ccctggccga cagcctgatg cagctggccc gccaggtgag ccgcctggag     1200

agcggccaga gcggcagcga gactcccggg acctcagagt ccgccacacc cgaaagtatg     1260

gataaaaagt attctattgg tttagctatc ggcactaatt ccgttggatg ggctgtcata     1320

accgatgaat acaaagtacc ttcaaagaaa tttaaggtgt tggggaacac agaccgtcat     1380

tcgattaaaa agaatcttat cggtgccctc ctattcgata gtggcgaaac ggcagaggcg     1440

actcgcctga aacgaaccgc tcggagaagg tatacacgtc gcaagaaccg aatatgttac     1500

ttacaagaaa tttttagcaa tgagatggcc aaagttgacg attctttctt tcaccgtttg     1560

gaagagtcct tccttgtcga agaggacaag aaacatgaac ggcaccccat ctttggaaac     1620

atagtagatg aggtggcata tcatgaaaag tacccaacga tttatcacct cagaaaaaag     1680

ctagttgact caactgataa agcggacctg aggttaatct acttggctct tgcccatatg     1740

ataaagttcc gtgggcactt tctcattgag ggtgatctaa atccggacaa ctcggatgtc     1800

gacaaactgt tcatccagtt agtacaaacc tataatcagt tgtttgaaga gaaccctata     1860

aatgcaagtg gcgtggatgc gaaggctatt cttagcgccc gcctctctaa atcccgacgg     1920

ctagaaaacc tgatcgcaca attacccgga gagaagaaaa atgggttgtt cggtaacctt     1980

atagcgctct cactaggcct gacaccaaat tttaagtcga acttcgactt agctgaagat     2040

gccaaattgc agcttagtaa ggacacgtac gatgacgatc tcgacaatct actggcacaa     2100

attggagatc agtatgcgga cttatttttg gctgccaaaa accttagcga tgcaatcctc     2160

ctatctgaca tactgagagt taatactgag attaccaagg cgccgttatc cgcttcaatg     2220

atcaaaaggt acgatgaaca tcaccaagac ttgacacttc tcaaggccct agtccgtcag     2280

caactgcctg agaaatataa ggaaatattc tttgatcagt cgaaaaacgg gtacgcaggt     2340

tatattgacg gcggagcgag tcaagaggaa ttctacaagt ttatcaaacc catattagag     2400

aagatggatg ggacggaaga gttgcttgta aaactcaatc gcgaagatct actgcgaaag     2460

cagcggactt tcgacaacgg tagcattcca catcaaatcc acttaggcga attgcatgct     2520

atacttagaa ggcaggagga tttttatccg ttcctcaaag acaatcgtga aaagattgag     2580

aaaatcctaa cctttcgcat accttactat gtgggacccc tggcccgagg gaactctcgg     2640

ttcgcatgga tgacaagaaa gtccgaagaa acgattactc catggaattt tgaggaagtt     2700

gtcgataaag gtgcgtcagc tcaatcgttc atcgagagga tgaccaactt tgacaagaat     2760

ttaccgaacg aaaaagtatt gcctaagcac agtttacttt acgagtattt cacagtgtac     2820

aatgaactca cgaaagttaa gtatgtcact gagggcatgc gtaaacccgc ctttctaagc     2880

ggagaacaga agaaagcaat agtagatctg ttattcaaga ccaaccgcaa agtgacagtt     2940

aagcaattga tcatctagac aataagttct ggttggcgtt tcactgtcaa ttcgttaact     3000

aagaggacta ctttaagaaa attgaatgct tcgattctgt cgagatctcc ggggtagaag     3060

atcgatttaa tgcgtcactt ggtacgtatc atgacctcct aaagataatt aaagataagg     3120

acttcctgga taacgaagag aatgaagata tcttagaaga tatagtgttg actcttaccc     3180

tctttgaaga tcgggaaatg attgaggaaa gactaaaaac atacgctcac ctgttcgacg     3240

ataaggttat gaaacagtta aagaggcgtc gctatacggg ctggggacga ttgtcgcgga     3300

aacttatcaa cgggataaga gacaagcaaa gtggtaaaac tattctcgat tttctaaaga     3360

gcgacggctt cgccaatagg aactttatgc agctgatcca tgatgactct ttaaccttca     3420

aagaggatat acaaaaggca caggtttccg gacaagggga ctcattgcac gaacatattg     3480

cgaatcttgc tggttcgcca gccatcaaaa agggcatact ccagacagtc aaagtagtgg     3540

atgagctagt taaggtcatg ggacgtcaca aaccggaaaa cattgtaatc gagatggcac     3600

gcgaaaatca aacgactcag aaggggcaaa aaaacagtcg agagcggatg aagagaatag     3660

aagagggtat taaagaactg ggcagccaga tcttaaagga gcatcctgtg gaaaataccc     3720

aattgcagaa cgagaaactt tacctctatt acctacaaaa tggaagggac atgtatgttg     3780

atcaggaact ggacataaac cgtttatctg attacgacgt cgatgccatt gtaccccaat     3840

cctttttgaa ggacgattca atcgacaata aagtgcttac acgctcggat aagaaccgag     3900

ggaaaagtga caatgttcca agcgaggaag tcgtaaagaa aatgaagaac tattggcggc     3960

agctcctaaa tgcgaaactg ataacgcaaa gaaagttcga taacttaact aaagctgaga     4020

ggggtggctt gtctgaactt gacaaggccg gatttattaa acgtcagctc gtggaaaccc     4080

gccaaatcac aaagcatgtt gcacagatac tagattcccg aatgaatacg aaatacgacg     4140

agaacgataa gctgattcgg gaagtcaaag taatcacttt aaagtcaaaa ttggtgtcgg     4200

acttcagaaa ggattttcaa ttctataaag ttagggagat aaataactac caccatgcgc     4260

acgacgctta tcttaatgcc gtcgtaggga ccgcactcat taagaaatac ccgaagctag     4320

aaagtgagtt tgtgtatggt gattacaaag tttatgacgt ccgtaagatg atcgcgaaaa     4380

gcgaacagga gataggcaag gctacagcca aatacttctt ttattctaac attatgaatt     4440

tctttaagac ggaaatcact ctggcaaacg gagagatacg caaacgacct ttaattgaaa     4500

ccaatgggga gacaggtgaa atcgtatggg ataagggccg ggacttcgcg acggtgagaa     4560

aagttttgtc catgccccaa gtcaacatag taaagaaaac tgaggtgcag accggagggt     4620

tttcaaagga atcgattctt ccaaaaagga atagtgataa gctcatcgct cgtaaaaagg     4680

actgggaccc gaaaaagtac ggtggcttcg atagccctac agttgcctat tctgtcctag     4740

tagtggcaaa agttgagaag ggaaaatcca agaaactgaa gtcagtcaaa gaattattgg     4800

ggataacgat tatggagcgc tcgtcttttg aaaagaaccc catcgacttc cttgaggcga     4860

aaggttacaa ggaagtaaaa aaggatctca taattaaact accaaagtat agtctgtttg     4920

agttagaaaa tggccgaaaa cggatgttgg ctagcgccgg agagcttcaa aaggggaacg     4980

aactcgcact accgtctaaa tacgtgaatt tcctgtattt agcgtcccat tacgagaagt     5040

tgaaaggttc acctgaagat aacgaacaga agcaactttt tgttgagcag cacaaacatt     5100

atctcgacga aatcatagag caaatttcgg aattcagtaa gagagtcatc ctagctgatg     5160

ccaatctgga caaagtatta agcgcataca acaagcacag ggataaaccc atacgtgagc     5220

aggcggaaaa tattatccat ttgtttactc ttaccaacct cggcgctcca gccgcattca     5280

agtattttga cacaacgata gatcgcaaac gatacacttc taccaaggag gtgctagacg     5340

cgacactgat tcaccaatcc atcacgggat tatatgaaac tcggatagat ttgtcacagc     5400

ttgggggtga c                                                          5411


<210>  9
<211>  1650
<212>  PRT
<213>  Synthetic


<220>
<221>  nuclear localization sequence
<222>  (1)..(39)

<220>
<221>  GGS linker
<222>  (40)..(42)

<220>
<221>  lacI domain
<222>  (43)..(403)

<220>
<221>  XTEN linker
<222>  (404)..(419)

<220>
<221>  Cas9 wild type
<222>  (420)..(1650)

<400>  9

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Arg Gly Val Pro Gly Gly Ser Met Met Lys Pro Val Thr 
        35                  40                  45              


Leu Tyr Asp Val Ala Glu Tyr Ala Gly Val Ser Tyr Gln Thr Val Ser 
    50                  55                  60                  


Arg Val Val Asn Gln Ala Ser His Val Ser Ala Lys Thr Arg Glu Lys 
65                  70                  75                  80  


Val Glu Ala Ala Met Ala Glu Leu Asn Tyr Ile Pro Asn Arg Val Ala 
                85                  90                  95      


Gln Gln Leu Ala Gly Lys Gln Ser Leu Leu Ile Gly Val Ala Thr Ser 
            100                 105                 110         


Ser Leu Ala Leu His Ala Pro Ser Gln Ile Val Ala Ala Ile Lys Ser 
        115                 120                 125             


Arg Ala Asp Gln Leu Gly Ala Ser Val Val Val Ser Met Val Glu Arg 
    130                 135                 140                 


Ser Gly Val Glu Ala Cys Lys Ala Ala Val His Asn Leu Leu Ala Gln 
145                 150                 155                 160 


Arg Val Ser Gly Leu Ile Ile Asn Tyr Pro Leu Asp Asp Gln Asp Ala 
                165                 170                 175     


Ile Ala Val Glu Ala Ala Cys Thr Asn Val Pro Ala Leu Phe Leu Asp 
            180                 185                 190         


Val Ser Asp Gln Thr Pro Ile Asn Ser Ile Ile Phe Ser His Glu Asp 
        195                 200                 205             


Gly Thr Arg Leu Gly Val Glu His Leu Val Ala Leu Gly His Gln Gln 
    210                 215                 220                 


Ile Ala Leu Leu Ala Gly Pro Leu Ser Ser Val Ser Ala Arg Leu Arg 
225                 230                 235                 240 


Leu Ala Gly Trp His Lys Tyr Leu Thr Arg Asn Gln Ile Gln Pro Ile 
                245                 250                 255     


Ala Glu Arg Glu Gly Asp Trp Ser Ala Met Ser Gly Phe Gln Gln Thr 
            260                 265                 270         


Met Gln Met Leu Asn Glu Gly Ile Val Pro Thr Ala Met Leu Val Ala 
        275                 280                 285             


Asn Asp Gln Met Ala Leu Gly Ala Met Arg Ala Ile Thr Glu Ser Gly 
    290                 295                 300                 


Leu Arg Val Gly Ala Asp Ile Ser Val Val Gly Tyr Asp Asp Thr Glu 
305                 310                 315                 320 


Asp Ser Ser Cys Tyr Ile Pro Pro Leu Thr Thr Ile Lys Gln Asp Phe 
                325                 330                 335     


Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu Leu Gln Leu Ser Gln 
            340                 345                 350         


Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro Val Ser Leu Val Lys 
        355                 360                 365             


Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr Ala Ser Pro Arg Ala 
    370                 375                 380                 


Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln Val Ser Arg Leu Glu 
385                 390                 395                 400 


Ser Gly Gln Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
                405                 410                 415     


Pro Glu Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
            420                 425                 430         


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
        435                 440                 445             


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
    450                 455                 460                 


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
465                 470                 475                 480 


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
                485                 490                 495     


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
            500                 505                 510         


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
        515                 520                 525             


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
    530                 535                 540                 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
545                 550                 555                 560 


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
                565                 570                 575     


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
            580                 585                 590         


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
        595                 600                 605             


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
    610                 615                 620                 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
625                 630                 635                 640 


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
                645                 650                 655     


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
            660                 665                 670         


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
        675                 680                 685             


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
    690                 695                 700                 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
705                 710                 715                 720 


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
                725                 730                 735     


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
            740                 745                 750         


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
        755                 760                 765             


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
    770                 775                 780                 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
785                 790                 795                 800 


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
                805                 810                 815     


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
            820                 825                 830         


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
        835                 840                 845             


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
    850                 855                 860                 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
865                 870                 875                 880 


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
                885                 890                 895     


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
            900                 905                 910         


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
        915                 920                 925             


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
    930                 935                 940                 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
945                 950                 955                 960 


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
                965                 970                 975     


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
            980                 985                 990         


Cys Phe Asp Ser Val Glu Ile Ser  Gly Val Glu Asp Arg  Phe Asn Ala 
        995                 1000                 1005             


Ser Leu  Gly Thr Tyr His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys 
    1010                 1015                 1020             


Asp Phe  Leu Asp Asn Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile 
    1025                 1030                 1035             


Val Leu  Thr Leu Thr Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu 
    1040                 1045                 1050             


Arg Leu  Lys Thr Tyr Ala His  Leu Phe Asp Asp Lys  Val Met Lys 
    1055                 1060                 1065             


Gln Leu  Lys Arg Arg Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg 
    1070                 1075                 1080             


Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile 
    1085                 1090                 1095             


Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met 
    1100                 1105                 1110             


Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln 
    1115                 1120                 1125             


Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser Leu His  Glu His Ile 
    1130                 1135                 1140             


Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln 
    1145                 1150                 1155             


Thr Val  Lys Val Val Asp Glu  Leu Val Lys Val Met  Gly Arg His 
    1160                 1165                 1170             


Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr 
    1175                 1180                 1185             


Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile 
    1190                 1195                 1200             


Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His 
    1205                 1210                 1215             


Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr 
    1220                 1225                 1230             


Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp 
    1235                 1240                 1245             


Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp Ala Ile  Val Pro Gln 
    1250                 1255                 1260             


Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg 
    1265                 1270                 1275             


Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu 
    1280                 1285                 1290             


Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala 
    1295                 1300                 1305             


Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu 
    1310                 1315                 1320             


Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg 
    1325                 1330                 1335             


Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys His Val  Ala Gln Ile 
    1340                 1345                 1350             


Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu 
    1355                 1360                 1365             


Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser 
    1370                 1375                 1380             


Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn 
    1385                 1390                 1395             


Asn Tyr  His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Val Gly 
    1400                 1405                 1410             


Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
    1415                 1420                 1425             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1430                 1435                 1440             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1445                 1450                 1455             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1460                 1465                 1470             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1475                 1480                 1485             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1490                 1495                 1500             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1505                 1510                 1515             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1520                 1525                 1530             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1535                 1540                 1545             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1550                 1555                 1560             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1565                 1570                 1575             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1580                 1585                 1590             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1595                 1600                 1605             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1610                 1615                 1620             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1625                 1630                 1635             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  
    1640                 1645                 1650 


<210>  10
<211>  22
<212>  DNA
<213>  Synthetic

<400>  10
ccttctctgt gaacctctat ca                                                22


<210>  11
<211>  20
<212>  DNA
<213>  Synthetic

<400>  11
gcagagtacc tgaaacagga                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Synthetic

<400>  12
cattcacagt agcttaccca                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Synthetic

<400>  13
ataggaaaca ccaaagatga                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Synthetic

<400>  14
ataggaaaca ccaatgatat                                                   20


<210>  15
<211>  40
<212>  DNA
<213>  Synthetic

<400>  15
ataggaaaca ccaatgatat tttctttaat ggtgccaggc                             40


<210>  16
<211>  41
<212>  DNA
<213>  Synthetic

<400>  16
gaaaatatca ttggtgtttc ctatgatgaa tatagataca g                           41


<210>  17
<211>  19
<212>  DNA
<213>  Synthetic

<400>  17
tgagttagat gtttgacgc                                                    19


<210>  18
<211>  31
<212>  DNA
<213>  Synthetic

<400>  18
gctgtgcatt ttcctctggg taatacttta g                                      31


<210>  19
<211>  24
<212>  DNA
<213>  Synthetic

<400>  19
gtctctatta cttaatctgt acct                                              24


<210>  20
<211>  36
<212>  DNA
<213>  Synthetic

<400>  20
ctgtgaagat taaataaatt aatatagtta aagcac                                 36


<210>  21
<211>  28
<212>  DNA
<213>  Synthetic

<400>  21
atgctcattc cattaggcta tagtatta                                          28


<210>  22
<211>  26
<212>  DNA
<213>  Synthetic

<400>  22
ctaattctct gctggcagat caatgc                                            26


<210>  23
<211>  34
<212>  DNA
<213>  Synthetic

<400>  23
caagacgttg tgttaggtac attacatgta catc                                   34


<210>  24
<211>  28
<212>  DNA
<213>  Synthetic

<400>  24
ctcccatgag gacggtacgc gactgggc                                          28


<210>  25
<211>  28
<212>  DNA
<213>  Synthetic

<400>  25
gcccagtcgc gtaccgtcct catgggag                                          28


<210>  26
<211>  39
<212>  DNA
<213>  Synthetic

<400>  26
gtgggatacg acgataccga ggacagctca tgttatatc                              39


<210>  27
<211>  39
<212>  DNA
<213>  Synthetic

<400>  27
gatataacat gagctgtcct cggtatcgtc gtatcccac                              39


<210>  28
<211>  29
<212>  DNA
<213>  Synthetic

<400>  28
atgaaaccag taacgttata cgatgtcgc                                         29


<210>  29
<211>  18
<212>  DNA
<213>  Synthetic

<400>  29
tcactgcccg ctttccag                                                     18


<210>  30
<211>  43
<212>  DNA
<213>  Synthetic

<400>  30
ggtatccacg gagtcccagc agccatgaaa ccagtaacgt tat                         43


<210>  31
<211>  23
<212>  DNA
<213>  Synthetic

<400>  31
ctggagcacc tgcctgaaat cac                                               23


<210>  32
<211>  27
<212>  DNA
<213>  Synthetic

<400>  32
cgcgtgcgcc aattctgcag acaaatg                                           27


<210>  33
<211>  34
<212>  DNA
<213>  Synthetic

<400>  33
tgctgggact ccgtggatac cgaccttccg cttc                                   34


<210>  34
<211>  43
<212>  DNA
<213>  Synthetic

<400>  34
ggtatccacg gagtcccagc agccgtgaaa ccagtaacgt tat                         43


<210>  35
<211>  51
<212>  DNA
<213>  Synthetic

<400>  35
ggcggactct gaggtcccgg gagtctcgct gccgctctgc ccgctttcca g                51


<210>  36
<211>  49
<212>  DNA
<213>  Synthetic

<400>  36
cgggacctca gagtccgcca cacccgaaag tgacaagaag tacagcatc                   49


<210>  37
<211>  26
<212>  DNA
<213>  Synthetic

<400>  37
cgtccacctt ggccatctcg ttgctg                                            26


<210>  38
<211>  58
<212>  DNA
<213>  Synthetic

<400>  38
gttcggaata taaattgtga gcgctcacaa ttaagcttgc agagtacctg aaacagga         58


<210>  39
<211>  58
<212>  DNA
<213>  Synthetic

<400>  39
gttcggaata taaattgtga gcgctcacaa ttaagcttca ttcacagtag cttaccca         58


<210>  40
<211>  59
<212>  DNA
<213>  Synthetic

<400>  40
gttcggaata taaattgtga gcgctcacaa ttaagcttgc tgtgcatttt cctctgggt        59


<210>  41
<211>  69
<212>  DNA
<213>  Synthetic

<400>  41
gttcggaata taaattgtga gcgctcacaa ttaagcttca agacgttgtg ttaggtacat       60

tacatgtac                                                               69


<210>  42
<211>  58
<212>  DNA
<213>  Synthetic

<400>  42
gaattcgagc tcggtacccg gggatcccaa gacgttgtgt taggtacatt acatgtac         58


<210>  43
<211>  47
<212>  DNA
<213>  Synthetic

<400>  43
gaattcgagc tcggtacccg gggatcccat tcacagtagc ttaccca                     47


<210>  44
<211>  50
<212>  DNA
<213>  Synthetic

<400>  44
cactccctat cagtgataga gaaaagaaag ctgtgcattt tcctctgggt                  50


<210>  45
<211>  58
<212>  DNA
<213>  Synthetic

<400>  45
cactccctat cagtgataga gaaacaagac gttgtgttag gtacattaca tgtacatc         58


<210>  46
<211>  46
<212>  DNA
<213>  Synthetic

<400>  46
cactccctat cagtgataga gaaaaggcag agtacctgaa acagga                      46


<210>  47
<211>  46
<212>  DNA
<213>  Synthetic

<400>  47
cactccctat cagtgataga gaaaagcatt cacagtagct taccca                      46


<210>  48
<211>  24
<212>  DNA
<213>  Synthetic

<400>  48
cggagcctat ggaaaaacgc cagc                                              24


<210>  49
<211>  25
<212>  DNA
<213>  Synthetic

<400>  49
caccgattaa agaaaatatc atctt                                             25


<210>  50
<211>  25
<212>  DNA
<213>  Synthetic

<400>  50
aaacaagatg atattttctt taatc                                             25


<210>  51
<211>  25
<212>  DNA
<213>  Synthetic

<400>  51
caccgaaaga tgatattttc tttaa                                             25


<210>  52
<211>  25
<212>  DNA
<213>  Guide

<400>  52
aaacttaaag aaaatatcat ctttc                                             25


<210>  53
<211>  25
<212>  DNA
<213>  Synthetic

<400>  53
caccgaccat taaagaaaat atcat                                             25


<210>  54
<211>  25
<212>  DNA
<213>  Synthetic

<400>  54
aaacatgata ttttctttaa tggtc                                             25


<210>  55
<211>  25
<212>  DNA
<213>  Synthetic

<400>  55
caccgaccaa tgatattttc tttaa                                             25


<210>  56
<211>  25
<212>  DNA
<213>  Synthetic

<400>  56
aaacttaaag aaaatatcat tggtc                                             25


<210>  57
<211>  20
<212>  DNA
<213>  Synthetic

<400>  57
aattgtgagc gctcacaatt                                                   20


<210>  58
<211>  24
<212>  DNA
<213>  Synthetic

<400>  58
cactccctat cagtgataga gaaa                                              24


<210>  59
<211>  42
<212>  DNA
<213>  Synthetic

<400>  59
tcgagtttac cactccctat cagtgataga gaaaagtgaa ag                          42


<210>  60
<211>  42
<212>  DNA
<213>  Synthetic

<400>  60
tcgactttca cttttctcta tcactgatag ggagtggtaa ac                          42


<210>  61
<211>  44
<212>  DNA
<213>  Synthetic

<400>  61
tcgagtttag tggaattgtg agcggataac aatttcactg aaag                        44


<210>  62
<211>  44
<212>  DNA
<213>  Synthetic

<400>  62
tcgactttca gtgaaattgt tatccgctca caattccact aaac                        44


<210>  63
<211>  10417
<212>  DNA
<213>  Synthetic

<400>  63
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg ggtcttcgag aagacctgtt ttagagctag aaatagcaag ttaaaataag      300

gctagtccgt tatcaacttg aaaaagtggc accgagtcgg tgcttttttg ttttagagct      360

agaaatagca agttaaaata aggctagtcc gtttttagcg cgtgcgccaa ttctgcagac      420

aaatggctct agaggtaccc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      480

ccaacgaccc ccgcccattg acgtcaatag taacgccaat agggactttc cattgacgtc      540

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      600

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tgtgcccagt      660

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      720

ccatggtcga ggtgagcccc acgttctgct tcactctccc catctccccc ccctccccac      780

ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg      840

ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga      900

gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc      960

ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgacgc     1020

tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg     1080

accgcgttac tcccacaggt gagcgggcgg gacggccctt ctcctccggg ctgtaattag     1140

ctgagcaaga ggtaagggtt taagggatgg ttggttggtg gggtattaat gtttaattac     1200

ctggagcacc tgcctgaaat cacttttttt caggttggac cggtgccacc atggactata     1260

aggaccacga cggagactac aaggatcatg atattgatta caaagacgat gacgataaga     1320

tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc gtgaaaccag     1380

taacgttata cgatgtcgca gagtatgccg gtgtctctta tcagaccgtt tcccgcgtgg     1440

tgaaccaggc cagccacgtt tctgcgaaaa cgcgggaaaa agtggaagcg gcgatggcgg     1500

agctgaatta cattcccaac cgcgtggcac aacaactggc gggcaaacag tcgttgctga     1560

ttggcgttgc cacctccagt ctggccctgc acgcgccgtc gcaaattgtc gcggcgatta     1620

aatctcgcgc cgatcaactg ggtgccagcg tggtggtgtc gatggtagaa cgaagcggcg     1680

tcgaagcctg taaagcggcg gtgcacaatc ttctcgcgca acgcgtcagt gggctgatca     1740

ttaactatcc gctggatgac caggatgcca ttgctgtgga agctgcctgc actaatgttc     1800

cggcgttatt tcttgatgtc tctgaccaga cacccatcaa cagtattatt ttctcccatg     1860

aggacggtac gcgactgggc gtggagcatc tggtcgcatt gggtcaccag caaatcgcgc     1920

tgttagcggg cccattaagt tctgtctcgg cgcgtctgcg tctggctggc tggcataaat     1980

atctcactcg caatcaaatt cagccgatag cggaacggga aggcgactgg agtgccatgt     2040

ccggttttca acaaaccatg caaatgctga atgagggcat cgttcccact gcgatgctgg     2100

ttgccaacga tcagatggcg ctgggcgcaa tgcgcgccat taccgagtcc gggctgcgcg     2160

ttggtgcgga tatctcggta gtgggatacg acgataccga ggacagctca tgttatatcc     2220

cgccgttaac caccatcaaa caggattttc gcctgctggg gcaaaccagc gtggaccgct     2280

tgctgcaact ctctcagggc caggcggtga agggcaatca gctgttgccc gtctcactgg     2340

tgaaaagaaa aaccaccctg gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg     2400

attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag agcggcagcg     2460

agactcccgg gacctcagag tccgccacac ccgaaagtga caagaagtac agcatcggcc     2520

tggacatcgg caccaactct gtgggctggg ccgtgatcac cgacgagtac aaggtgccca     2580

gcaagaaatt caaggtgctg ggcaacaccg accggcacag catcaagaag aacctgatcg     2640

gagccctgct gttcgacagc ggcgaaacag ccgaggccac ccggctgaag agaaccgcca     2700

gaagaagata caccagacgg aagaaccgga tctgctatct gcaagagatc ttcagcaacg     2760

agatggccaa ggtggacgac agcttcttcc acagactgga agagtccttc ctggtggaag     2820

aggataagaa gcacgagcgg caccccatct tcggcaacat cgtggacgag gtggcctacc     2880

acgagaagta ccccaccatc taccacctga gaaagaaact ggtggacagc accgacaagg     2940

ccgacctgcg gctgatctat ctggccctgg cccacatgat caagttccgg ggccacttcc     3000

tgatcgaggg cgacctgaac cccgacaaca gcgacgtgga caagctgttc atccagctgg     3060

tgcagaccta caaccagctg ttcgaggaaa accccatcaa cgccagcggc gtggacgcca     3120

aggccatcct gtctgccaga ctgagcaaga gcagacggct ggaaaatctg atcgcccagc     3180

tgcccggcga gaagaagaat ggcctgttcg gaaacctgat tgccctgagc ctgggcctga     3240

cccccaactt caagagcaac ttcgacctgg ccgaggatgc caaactgcag ctgagcaagg     3300

acacctacga cgacgacctg gacaacctgc tggcccagat cggcgaccag tacgccgacc     3360

tgtttctggc cgccaagaac ctgtccgacg ccatcctgct gagcgacatc ctgagagtga     3420

acaccgagat caccaaggcc cccctgagcg cctctatgat caagagatac gacgagcacc     3480

accaggacct gaccctgctg aaagctctcg tgcggcagca gctgcctgag aagtacaaag     3540

agattttctt cgaccagagc aagaacggct acgccggcta cattgacggc ggagccagcc     3600

aggaagagtt ctacaagttc atcaagccca tcctggaaaa gatggacggc accgaggaac     3660

tgctcgtgaa gctgaacaga gaggacctgc tgcggaagca gcggaccttc gacaacggca     3720

gcatccccca ccagatccac ctgggagagc tgcacgccat tctgcggcgg caggaagatt     3780

tttacccatt cctgaaggac aaccgggaaa agatcgagaa gatcctgacc ttccgcatcc     3840

cctactacgt gggccctctg gccaggggaa acagcagatt cgcctggatg accagaaaga     3900

gcgaggaaac catcaccccc tggaacttcg aggaagtggt ggacaagggc gcttccgccc     3960

agagcttcat cgagcggatg accaacttcg ataagaacct gcccaacgag aaggtgctgc     4020

ccaagcacag cctgctgtac gagtacttca ccgtgtataa cgagctgacc aaagtgaaat     4080

acgtgaccga gggaatgaga aagcccgcct tcctgagcgg cgagcagaaa aaggccatcg     4140

tggacctgct gttcaagacc aaccggaaag tgaccgtgaa gcagctgaaa gaggactact     4200

tcaagaaaat cgagtgcttc gactccgtgg aaatctccgg cgtggaagat cggttcaacg     4260

cctccctggg cacataccac gatctgctga aaattatcaa ggacaaggac ttcctggaca     4320

atgaggaaaa cgaggacatt ctggaagata tcgtgctgac cctgacactg tttgaggaca     4380

gagagatgat cgaggaacgg ctgaaaacct atgcccacct gttcgacgac aaagtgatga     4440

agcagctgaa gcggcggaga tacaccggct ggggcaggct gagccggaag ctgatcaacg     4500

gcatccggga caagcagtcc ggcaagacaa tcctggattt cctgaagtcc gacggcttcg     4560

ccaacagaaa cttcatgcag ctgatccacg acgacagcct gacctttaaa gaggacatcc     4620

agaaagccca ggtgtccggc cagggcgata gcctgcacga gcacattgcc aatctggccg     4680

gcagccccgc cattaagaag ggcatcctgc agacagtgaa ggtggtggac gagctcgtga     4740

aagtgatggg ccggcacaag cccgagaaca tcgtgatcga aatggccaga gagaaccaga     4800

ccacccagaa gggacagaag aacagccgcg agagaatgaa gcggatcgaa gagggcatca     4860

aagagctggg cagccagatc ctgaaagaac accccgtgga aaacacccag ctgcagaacg     4920

agaagctgta cctgtactac ctgcagaatg ggcgggatat gtacgtggac caggaactgg     4980

acatcaaccg gctgtccgac tacgatgtgg accatatcgt gcctcagagc tttctgaagg     5040

acgactccat cgacaacaag gtgctgacca gaagcgacaa gaaccggggc aagagcgaca     5100

acgtgccctc cgaagaggtc gtgaagaaga tgaagaacta ctggcggcag ctgctgaacg     5160

ccaagctgat tacccagaga aagttcgaca atctgaccaa ggccgagaga ggcggcctga     5220

gcgaactgga taaggccggc ttcatcaaga gacagctggt ggaaacccgg cagatcacaa     5280

agcacgtggc acagatcctg gactcccgga tgaacactaa gtacgacgag aatgacaagc     5340

tgatccggga agtgaaagtg atcaccctga agtccaagct ggtgtccgat ttccggaagg     5400

atttccagtt ttacaaagtg cgcgagatca acaactacca ccacgcccac gacgcctacc     5460

tgaacgccgt cgtgggaacc gccctgatca aaaagtaccc taagctggaa agcgagttcg     5520

tgtacggcga ctacaaggtg tacgacgtgc ggaagatgat cgccaagagc gagcaggaaa     5580

tcggcaaggc taccgccaag tacttcttct acagcaacat catgaacttt ttcaagaccg     5640

agattaccct ggccaacggc gagatccgga agcggcctct gatcgagaca aacggcgaaa     5700

ccggggagat cgtgtgggat aagggccggg attttgccac cgtgcggaaa gtgctgagca     5760

tgccccaagt gaatatcgtg aaaaagaccg aggtgcagac aggcggcttc agcaaagagt     5820

ctatcctgcc caagaggaac agcgataagc tgatcgccag aaagaaggac tgggacccta     5880

agaagtacgg cggcttcgac agccccaccg tggcctattc tgtgctggtg gtggccaaag     5940

tggaaaaggg caagtccaag aaactgaaga gtgtgaaaga gctgctgggg atcaccatca     6000

tggaaagaag cagcttcgag aagaatccca tcgactttct ggaagccaag ggctacaaag     6060

aagtgaaaaa ggacctgatc atcaagctgc ctaagtactc cctgttcgag ctggaaaacg     6120

gccggaagag aatgctggcc tctgccggcg aactgcagaa gggaaacgaa ctggccctgc     6180

cctccaaata tgtgaacttc ctgtacctgg ccagccacta tgagaagctg aagggctccc     6240

ccgaggataa tgagcagaaa cagctgtttg tggaacagca caagcactac ctggacgaga     6300

tcatcgagca gatcagcgag ttctccaaga gagtgatcct ggccgacgct aatctggaca     6360

aagtgctgtc cgcctacaac aagcaccggg ataagcccat cagagagcag gccgagaata     6420

tcatccacct gtttaccctg accaatctgg gagcccctgc cgccttcaag tactttgaca     6480

ccaccatcga ccggaagagg tacaccagca ccaaagaggt gctggacgcc accctgatcc     6540

accagagcat caccggcctg tacgagacac ggatcgacct gtctcagctg ggaggcgaca     6600

aaaggccggc ggccacgaaa aaggccggcc aggcaaaaaa gaaaaaggaa ttcggcagtg     6660

gagagggcag aggaagtctg ctaacatgcg gtgacgtcga ggagaatcct ggcccagtga     6720

gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg     6780

taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc     6840

tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga     6900

ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg     6960

acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg     7020

acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc     7080

gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg     7140

agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca     7200

aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact     7260

accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga     7320

gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg     7380

agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag gaattctaac     7440

tagagctcgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc     7500

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     7560

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     7620

gcaggacagc aagggggagg attgggaaga gaatagcagg catgctgggg agcggccgca     7680

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     7740

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg     7800

agcgcgcagc tgcctgcagg ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg     7860

tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc     7920

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     7980

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     8040

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     8100

aaacttgatt tgggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     8160

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     8220

ctcaacccta tctcgggcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     8280

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     8340

tttacaattt tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag     8400

ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc     8460

gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca     8520

tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc     8580

atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc     8640

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     8700

tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc     8760

gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg     8820

gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat     8880

ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc     8940

acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa     9000

ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa     9060

aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt     9120

gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct     9180

tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat     9240

gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg     9300

cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg     9360

atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt     9420

attgctgata aatctggagc cggtgagcgt ggaagccgcg gtatcattgc agcactgggg     9480

ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg     9540

gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg     9600

tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa     9660

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     9720

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     9780

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     9840

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     9900

ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta     9960

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat    10020

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg    10080

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg    10140

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac    10200

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga    10260

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt    10320

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta    10380

cggttcctgg ccttttgctg gccttttgct cacatgt                             10417


<210>  64
<211>  9958
<212>  DNA
<213>  Synthetic

<400>  64
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg ggtcttcgag aagacctgtt ttagagctag aaatagcaag ttaaaataag      300

gctagtccgt tatcaacttg aaaaagtggc accgagtcgg tgcttttttg ttttagagct      360

agaaatagca agttaaaata aggctagtcc gtttttagcg cgtgcgccaa ttctgcagac      420

aaatggctct agaggtaccc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      480

ccaacgaccc ccgcccattg acgtcaatag taacgccaat agggactttc cattgacgtc      540

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      600

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tgtgcccagt      660

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      720

ccatggtcga ggtgagcccc acgttctgct tcactctccc catctccccc ccctccccac      780

ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg      840

ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga      900

gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc      960

ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgacgc     1020

tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg     1080

accgcgttac tcccacaggt gagcgggcgg gacggccctt ctcctccggg ctgtaattag     1140

ctgagcaaga ggtaagggtt taagggatgg ttggttggtg gggtattaat gtttaattac     1200

ctggagcacc tgcctgaaat cacttttttt caggttggac cggtgccacc atggactata     1260

aggaccacga cggagactac aaggatcatg atattgatta caaagacgat gacgataaga     1320

tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc atgtctagac     1380

tggataaaag taaagtgatt aacagcgcac tggagctgct taatgaggtc ggaatcgaag     1440

gtctgacaac cagaaaactc gcccagaagc tgggtgtaga gcagcctaca ttgtattggc     1500

atgtaaaaaa taagcgggct ttgctcgacg ccctggccat tgagatgctg gataggcacc     1560

atactcactt ttgccctctg gaaggggaaa gctggcaaga ttttctgaga aataacgcta     1620

aaagttttag atgtgctctg ctgagtcatc gcgatggagc aaaagtacat ctgggtacac     1680

ggcctacaga aaaacagtat gaaactctcg aaaatcaact ggcctttctg tgccaacaag     1740

gtttttcact ggagaatgca ctgtatgcac tcagcgctgt ggggcatttt actctgggtt     1800

gcgtattgga agatcaagag catcaagtcg ctaaagaaga aagggaaaca cctactactg     1860

atagtatgcc gccactgctg cgacaagcta tcgaactgtt tgatcaccaa ggtgcagagc     1920

cagccttcct gttcggcctt gaattgatca tatgcggact ggaaaaacaa cttaaatgtg     1980

aaagtgggtc tagcggcagc gagactcccg ggacctcaga gtccgccaca cccgaaagtg     2040

acaagaagta cagcatcggc ctggacatcg gcaccaactc tgtgggctgg gccgtgatca     2100

ccgacgagta caaggtgccc agcaagaaat tcaaggtgct gggcaacacc gaccggcaca     2160

gcatcaagaa gaacctgatc ggagccctgc tgttcgacag cggcgaaaca gccgaggcca     2220

cccggctgaa gagaaccgcc agaagaagat acaccagacg gaagaaccgg atctgctatc     2280

tgcaagagat cttcagcaac gagatggcca aggtggacga cagcttcttc cacagactgg     2340

aagagtcctt cctggtggaa gaggataaga agcacgagcg gcaccccatc ttcggcaaca     2400

tcgtggacga ggtggcctac cacgagaagt accccaccat ctaccacctg agaaagaaac     2460

tggtggacag caccgacaag gccgacctgc ggctgatcta tctggccctg gcccacatga     2520

tcaagttccg gggccacttc ctgatcgagg gcgacctgaa ccccgacaac agcgacgtgg     2580

acaagctgtt catccagctg gtgcagacct acaaccagct gttcgaggaa aaccccatca     2640

acgccagcgg cgtggacgcc aaggccatcc tgtctgccag actgagcaag agcagacggc     2700

tggaaaatct gatcgcccag ctgcccggcg agaagaagaa tggcctgttc ggaaacctga     2760

ttgccctgag cctgggcctg acccccaact tcaagagcaa cttcgacctg gccgaggatg     2820

ccaaactgca gctgagcaag gacacctacg acgacgacct ggacaacctg ctggcccaga     2880

tcggcgacca gtacgccgac ctgtttctgg ccgccaagaa cctgtccgac gccatcctgc     2940

tgagcgacat cctgagagtg aacaccgaga tcaccaaggc ccccctgagc gcctctatga     3000

tcaagagata cgacgagcac caccaggacc tgaccctgct gaaagctctc gtgcggcagc     3060

agctgcctga gaagtacaaa gagattttct tcgaccagag caagaacggc tacgccggct     3120

acattgacgg cggagccagc caggaagagt tctacaagtt catcaagccc atcctggaaa     3180

agatggacgg caccgaggaa ctgctcgtga agctgaacag agaggacctg ctgcggaagc     3240

agcggacctt cgacaacggc agcatccccc accagatcca cctgggagag ctgcacgcca     3300

ttctgcggcg gcaggaagat ttttacccat tcctgaagga caaccgggaa aagatcgaga     3360

agatcctgac cttccgcatc ccctactacg tgggccctct ggccagggga aacagcagat     3420

tcgcctggat gaccagaaag agcgaggaaa ccatcacccc ctggaacttc gaggaagtgg     3480

tggacaaggg cgcttccgcc cagagcttca tcgagcggat gaccaacttc gataagaacc     3540

tgcccaacga gaaggtgctg cccaagcaca gcctgctgta cgagtacttc accgtgtata     3600

acgagctgac caaagtgaaa tacgtgaccg agggaatgag aaagcccgcc ttcctgagcg     3660

gcgagcagaa aaaggccatc gtggacctgc tgttcaagac caaccggaaa gtgaccgtga     3720

agcagctgaa agaggactac ttcaagaaaa tcgagtgctt cgactccgtg gaaatctccg     3780

gcgtggaaga tcggttcaac gcctccctgg gcacatacca cgatctgctg aaaattatca     3840

aggacaagga cttcctggac aatgaggaaa acgaggacat tctggaagat atcgtgctga     3900

ccctgacact gtttgaggac agagagatga tcgaggaacg gctgaaaacc tatgcccacc     3960

tgttcgacga caaagtgatg aagcagctga agcggcggag atacaccggc tggggcaggc     4020

tgagccggaa gctgatcaac ggcatccggg acaagcagtc cggcaagaca atcctggatt     4080

tcctgaagtc cgacggcttc gccaacagaa acttcatgca gctgatccac gacgacagcc     4140

tgacctttaa agaggacatc cagaaagccc aggtgtccgg ccagggcgat agcctgcacg     4200

agcacattgc caatctggcc ggcagccccg ccattaagaa gggcatcctg cagacagtga     4260

aggtggtgga cgagctcgtg aaagtgatgg gccggcacaa gcccgagaac atcgtgatcg     4320

aaatggccag agagaaccag accacccaga agggacagaa gaacagccgc gagagaatga     4380

agcggatcga agagggcatc aaagagctgg gcagccagat cctgaaagaa caccccgtgg     4440

aaaacaccca gctgcagaac gagaagctgt acctgtacta cctgcagaat gggcgggata     4500

tgtacgtgga ccaggaactg gacatcaacc ggctgtccga ctacgatgtg gaccatatcg     4560

tgcctcagag ctttctgaag gacgactcca tcgacaacaa ggtgctgacc agaagcgaca     4620

agaaccgggg caagagcgac aacgtgccct ccgaagaggt cgtgaagaag atgaagaact     4680

actggcggca gctgctgaac gccaagctga ttacccagag aaagttcgac aatctgacca     4740

aggccgagag aggcggcctg agcgaactgg ataaggccgg cttcatcaag agacagctgg     4800

tggaaacccg gcagatcaca aagcacgtgg cacagatcct ggactcccgg atgaacacta     4860

agtacgacga gaatgacaag ctgatccggg aagtgaaagt gatcaccctg aagtccaagc     4920

tggtgtccga tttccggaag gatttccagt tttacaaagt gcgcgagatc aacaactacc     4980

accacgccca cgacgcctac ctgaacgccg tcgtgggaac cgccctgatc aaaaagtacc     5040

ctaagctgga aagcgagttc gtgtacggcg actacaaggt gtacgacgtg cggaagatga     5100

tcgccaagag cgagcaggaa atcggcaagg ctaccgccaa gtacttcttc tacagcaaca     5160

tcatgaactt tttcaagacc gagattaccc tggccaacgg cgagatccgg aagcggcctc     5220

tgatcgagac aaacggcgaa accggggaga tcgtgtggga taagggccgg gattttgcca     5280

ccgtgcggaa agtgctgagc atgccccaag tgaatatcgt gaaaaagacc gaggtgcaga     5340

caggcggctt cagcaaagag tctatcctgc ccaagaggaa cagcgataag ctgatcgcca     5400

gaaagaagga ctgggaccct aagaagtacg gcggcttcga cagccccacc gtggcctatt     5460

ctgtgctggt ggtggccaaa gtggaaaagg gcaagtccaa gaaactgaag agtgtgaaag     5520

agctgctggg gatcaccatc atggaaagaa gcagcttcga gaagaatccc atcgactttc     5580

tggaagccaa gggctacaaa gaagtgaaaa aggacctgat catcaagctg cctaagtact     5640

ccctgttcga gctggaaaac ggccggaaga gaatgctggc ctctgccggc gaactgcaga     5700

agggaaacga actggccctg ccctccaaat atgtgaactt cctgtacctg gccagccact     5760

atgagaagct gaagggctcc cccgaggata atgagcagaa acagctgttt gtggaacagc     5820

acaagcacta cctggacgag atcatcgagc agatcagcga gttctccaag agagtgatcc     5880

tggccgacgc taatctggac aaagtgctgt ccgcctacaa caagcaccgg gataagccca     5940

tcagagagca ggccgagaat atcatccacc tgtttaccct gaccaatctg ggagcccctg     6000

ccgccttcaa gtactttgac accaccatcg accggaagag gtacaccagc accaaagagg     6060

tgctggacgc caccctgatc caccagagca tcaccggcct gtacgagaca cggatcgacc     6120

tgtctcagct gggaggcgac aaaaggccgg cggccacgaa aaaggccggc caggcaaaaa     6180

agaaaaagga attcggcagt ggagagggca gaggaagtct gctaacatgc ggtgacgtcg     6240

aggagaatcc tggcccagtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc     6300

tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg     6360

gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg     6420

tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc     6480

ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg     6540

agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg     6600

agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca     6660

acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg     6720

acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca     6780

gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc     6840

tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc     6900

gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg     6960

agctgtacaa ggaattctaa ctagagctcg ctgatcagcc tcgactgtgc cttctagttg     7020

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     7080

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     7140

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag agaatagcag     7200

gcatgctggg gagcggccgc aggaacccct agtgatggag ttggccactc cctctctgcg     7260

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     7320

ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag gggcgcctga tgcggtattt     7380

tctccttacg catctgtgcg gtatttcaca ccgcatacgt caaagcaacc atagtacgcg     7440

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     7500

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     7560

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct     7620

ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg gttcacgtag tgggccatcg     7680

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     7740

ttgttccaaa ctggaacaac actcaaccct atctcgggct attcttttga tttataaggg     7800

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     7860

aattttaaca aaatattaac gtttacaatt ttatggtgca ctctcagtac aatctgctct     7920

gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc gccctgacgg     7980

gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg     8040

tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc     8100

ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt     8160

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat     8220

ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg     8280

agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt     8340

tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga     8400

gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa     8460

gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt     8520

attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt     8580

gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc     8640

agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga     8700

ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat     8760

cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct     8820

gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc     8880

cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg     8940

gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tggaagccgc     9000

ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg     9060

acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca     9120

ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta     9180

aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc     9240

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     9300

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     9360

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     9420

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     9480

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     9540

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     9600

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     9660

cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt     9720

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     9780

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     9840

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     9900

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgt       9958


<210>  65
<211>  3465
<212>  DNA
<213>  Synthetic

<400>  65
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt accactttcg      420

ggtgtggcgg actctgaggt cccgggagtc tcgctgccgc tagacccact ttcacattta      480

agttgttttt ccagtccgca tatgatcaat tcaaggccga acaggaaggc tggctctgca      540

ccttggtgat caaacagttc gatagcttgt cgcagcagtg gcggcatact atcagtagta      600

ggtgtttccc tttcttcttt agcgacttga tgctcttgat cttccaatac gcaacccaga      660

gtaaaatgcc ccacagcgct gagtgcatac agtgcattct ccagtgaaaa accttgttgg      720

cacagaaagg ccagttgatt ttcgagagtt tcatactgtt tttctgtagg ccgtgtaccc      780

agatgtactt ttgctccatc gcgatgactc agcagagcac atctaaaact tttagcgtta      840

tttctcagaa aatcttgcca gctttcccct tccagagggc aaaagtgagt atggtgccta      900

tccagcatct caatggccag ggcgtcgagc aaagcccgct tattttttac atgccaatac      960

aatgtaggct gctctacacc cagcttctgg gcgagttttc tggttgtcag accttcgatt     1020

ccgacctcat taagcagctc cagtgcgctg ttaatcactt tacttttatc cagtctagac     1080

atggctgctg ggactccgtg gataccgacc ttccgcttct tctttggggc catcttatcg     1140

tcatcgtctt tgtaatcaat atcatgatcc ttgtagtctc cgtcgtggtc cttatagtcc     1200

atgtcgactg cagaggcctg catgcaagct tggcgtaatc atggtcatag ctgtttcctg     1260

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     1320

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     1380

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     1440

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     1500

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     1560

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     1620

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     1680

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     1740

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     1800

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     1860

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     1920

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     1980

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     2040

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta     2100

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     2160

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     2220

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     2280

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     2340

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     2400

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     2460

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     2520

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     2580

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     2640

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     2700

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     2760

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     2820

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     2880

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     2940

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     3000

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag     3060

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     3120

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     3180

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     3240

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     3300

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     3360

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc attattatca     3420

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtc                     3465


<210>  66
<211>  29
<212>  DNA
<213>  Synthetic

<400>  66
gtggaattgt gagcggataa caatttcac                                         29


<210>  67
<211>  19
<212>  DNA
<213>  Synthetic

<400>  67
tccctatcag tgatagaga                                                    19


<210>  68
<211>  33
<212>  DNA
<213>  Syntehtic

<400>  68
aaactatcgt actagttaac tagtacgata gtt                                    33


<210>  69
<211>  3792
<212>  DNA
<213>  Homo sapiens

<400>  69
atgaataacg gaactaataa cttccaaaac ttcatcggga tcagttcctt gcagaaaact       60

ctccggaatg ctctcatccc aactgagact actcagcagt tcattgttaa gaatggaatc      120

ataaaagagg acgagcttag gggggaaaat aggcaaatcc tcaaggatat catggatgac      180

tattataggg gctttatatc cgagacactg agcagcattg atgatataga ctggacctct      240

cttttcgaaa agatggaaat acaacttaaa aatggagata acaaggacac cctgataaag      300

gaacagaccg aatataggaa ggcaattcat aaaaagtttg ctaacgatga taggtttaaa      360

aacatgttct cagcaaaact catttcagat atactgcccg aattcgttat ccacaacaac      420

aactactccg ctagcgaaaa agaggaaaag acccaagtca taaagctgtt ctctcgattc      480

gcgacgagtt ttaaagatta tttcaagaat cgcgcaaact gtttctcagc tgatgatatc      540

agcagctcat cctgtcatcg gatcgttaac gataatgctg aaatcttctt ctccaatgca      600

cttgtttata ggcgcattgt taaatctctc tcaaacgatg atatcaataa gatttccggc      660

gatatgaagg acagtcttaa ggagatgagc ctcgaagaga tatactcata cgagaaatat      720

ggcgaattta tcacccagga agggatttcc ttctataatg acatttgcgg caaagtcaat      780

tccttcatga acctgtattg ccaaaaaaat aaagaaaaca agaacctcta taagctgcaa      840

aagttgcata agcaaatact ttgtatcgcg gatacaagct atgaagttcc ctacaagttc      900

gagagtgatg aggaggtgta tcaatctgtc aatggtttcc ttgataatat ttcttctaag      960

catattgttg aacgactccg aaagatagga gacaactata atggatacaa tttggataaa     1020

atctacatcg tgtctaaatt ttacgagagt gtgtcacaaa aaacatatag agactgggag     1080

acaattaata ccgccctgga gatacattac aacaatatac ttcccgggaa cgggaagtct     1140

aaggcagaca aggtgaagaa agccgtgaag aacgacttgc aaaagtcaat taccgaaatc     1200

aatgagcttg tttcaaacta taaactttgt tcagatgaca atattaaagc cgaaacctat     1260

attcatgaaa tctctcatat tctgaataac tttgaggcgc aagaactgaa atataaccca     1320

gaaatacacc tcgttgagtc cgaactgaaa gcaagcgaac tgaaaaatgt tttggacgtg     1380

ataatgaacg cttttcattg gtgctcagtc tttatgacag aggagcttgt tgacaaggat     1440

aacaatttct atgcggaact ggaagagatt tacgacgaaa tctatccggt catatccctg     1500

tataacctgg ttcgcaacta tgtcacgcaa aaaccataca gcacgaagaa gattaaactg     1560

aactttggta ttccgacgct ggccgatgga tggtcaaaat ctaaggaata ctcaaacaat     1620

gccataatcc tgatgcgaga taacctctac taccttggaa tctttaatgc taaaaataaa     1680

cccgataaaa aaattatcga agggaacacg agtgaaaaca aaggtgatta taaaaaaatg     1740

atatataatc tgcttccagg accaaataag atgataccca aagttttcct ttcttcaaag     1800

accggcgtcg agacatataa accatccgcg tacatacttg aaggctacaa acaaaataaa     1860

catatcaaat catctaagga ttttgacatt acgttctgtc atgatttgat tgactatttc     1920

aaaaattgca tagccattca tccagagtgg aaaaactttg ggtttgactt ctctgatacc     1980

agtacatatg aagacataag tggattttac cgagaagtag agctccaagg ttataaaata     2040

gactggacct atatatctga aaaggatata gaccttttgc aagagaaggg acagctttat     2100

cttttccaaa tctacaacaa agacttcagt aagaaaagta ccgggaatga caatcttcat     2160

accatgtatc tgaagaacct gttctccgaa gaaaatctga aggacatagt cctgaagctt     2220

aatggcgaag cggaaatttt tttccgaaag agctctatta agaaccccat aatacataag     2280

aagggaagca ttctcgttaa tcgaacgtat gaggccgaag agaaagatca atttgggaat     2340

atccaaatcg ttcgaaagaa cataccagaa aatatttacc aagaattgta caaatatttt     2400

aacgataaaa gcgacaaaga actgtctgat gaagctgcta agctgaaaaa cgtcgtcggc     2460

catcatgagg ccgcgacgaa tatagtcaag gattaccgat atacatacga taagtatttc     2520

ctgcatatgc ccatcactat caactttaag gcaaataaga ctggattcat taatgacaga     2580

atactgcaat acatagctaa agaaaaagat ttgcatgtta ttggcattga caggggtgag     2640

cgcaatctta tctatgtaag cgtcattgat acttgcggga atatcgtaga gcagaagtca     2700

tttaatattg taaatgggta cgattaccaa atcaagttga agcagcaaga gggagcacga     2760

cagattgccc gcaaggagtg gaaagagatc ggaaagataa aggagatcaa ggaggggtat     2820

ttgtcccttg ttatacacga aatttccaag atggtaatca agtacaacgc tataattgct     2880

atggaggatc tctcctatgg atttaaaaag ggaagattta aagtcgagcg gcaggtatat     2940

cagaaatttg aaacaatgct tattaataaa cttaattatc tcgttttcaa agacattagt     3000

atcaccgaaa acggtgggct gttgaagggc tatcaactta cgtacatacc agataagctt     3060

aagaatgtgg gtcaccaatg cggatgcata ttctacgtgc ccgcagctta tacaagcaaa     3120

atcgacccaa caacgggttt cgtaaacata tttaagttca aggatctcac cgtggatgcc     3180

aagcgagagt tcataaaaaa atttgactca atcagatatg actcagaaaa gaatcttttt     3240

tgttttacct tcgactacaa taatttcatt acacaaaata cggttatgag caagtcatcc     3300

tggtccgtat atacgtatgg agtgcgcata aagcggagat tcgttaacgg gcgattttct     3360

aatgagtccg atacaatcga tataacaaag gatatggaaa aaactctgga aatgactgat     3420

ataaattgga gggacggtca tgacctcagg caagacatta tcgattatga gatcgtgcaa     3480

catatttttg agatctttcg gttgactgtc caaatgagga actctctgtc tgaattggaa     3540

gatagggact acgatcgcct gataagcccc gtgttgaacg agaataacat attctacgat     3600

tccgcgaaag ccggggatgc gctccctaag gacgccgatg caaatggggc ctattgtatt     3660

gctttgaaag ggctgtacga aatcaaacag atcaccgaaa actggaaaga agacgggaag     3720

tttagtcggg ataaactgaa gatatccaac aaggactggt ttgactttat ccaaaataag     3780

cgatatttgt aa                                                         3792


<210>  70
<211>  3792
<212>  DNA
<213>  E. coli

<400>  70
atgaacaacg gcacaaataa ttttcagaac ttcatcggga tctcaagttt gcagaaaacg       60

ctgcgcaatg ctctgatccc cacggaaacc acgcaacagt tcatcgtcaa gaacggaata      120

attaaagaag atgagttacg tggcgagaac cgccagattc tgaaagatat catggatgac      180

tactaccgcg gattcatctc tgagactctg agttctattg atgacataga ttggactagc      240

ctgttcgaaa aaatggaaat tcagctgaaa aatggtgata ataaagatac cttaattaag      300

gaacagacag agtatcggaa agcaatccat aaaaaatttg cgaacgacga tcggtttaag      360

aacatgttta gcgccaaact gattagtgac atattacctg aatttgtcat ccacaacaat      420

aattattcgg catcagagaa agaggaaaaa acccaggtga taaaattgtt ttcgcgcttt      480

gcgactagct ttaaagatta cttcaagaac cgtgcaaatt gcttttcagc ggacgatatt      540

tcatcaagca gctgccatcg catcgtcaac gacaatgcag agatattctt ttcaaatgcg      600

ctggtctacc gccggatcgt aaaatcgctg agcaatgacg atatcaacaa aatttcgggc      660

gatatgaaag attcattaaa agaaatgagt ctggaagaaa tatattctta cgagaagtat      720

ggggaattta ttacccagga aggcattagc ttctataatg atatctgtgg gaaagtgaat      780

tcttttatga acctgtattg tcagaaaaat aaagaaaaca aaaatttata caaacttcag      840

aaacttcaca aacagattct atgcattgcg gacactagct atgaggtccc gtataaattt      900

gaaagtgacg aggaagtgta ccaatcagtt aacggcttcc ttgataacat tagcagcaaa      960

catatagtcg aaagattacg caaaatcggc gataactata acggctacaa cctggataaa     1020

atttatatcg tgtccaaatt ttacgagagc gttagccaaa aaacctaccg cgactgggaa     1080

acaattaata ccgccctcga aattcattac aataatatct tgccgggtaa cggtaaaagt     1140

aaagccgaca aagtaaaaaa agcggttaag aatgatttac agaaatccat caccgaaata     1200

aatgaactag tgtcaaacta taagctgtgc agtgacgaca acatcaaagc ggagacttat     1260

atacatgaga ttagccatat cttgaataac tttgaagcac aggaattgaa atacaatccg     1320

gaaattcacc tagttgaatc cgagctcaaa gcgagtgagc ttaaaaacgt gctggacgtg     1380

atcatgaatg cgtttcattg gtgttcggtt tttatgactg aggaacttgt tgataaagac     1440

aacaattttt atgcggaact ggaggagatt tacgatgaaa tttatccagt aattagtctg     1500

tacaacctgg ttcgtaacta cgttacccag aaaccgtaca gcacgaaaaa gattaaattg     1560

aactttggaa taccgacgtt agcagacggt tggtcaaagt ccaaagagta ttctaataac     1620

gctatcatac tgatgcgcga caatctgtat tatctgggca tctttaatgc gaagaataaa     1680

ccggacaaga agattatcga gggtaatacg tcagaaaata agggtgacta caaaaagatg     1740

atttataatt tgctcccggg tcccaacaaa atgatcccga aagttttctt gagcagcaag     1800

acgggggtgg aaacgtataa accgagcgcc tatatcctag aggggtataa acagaataaa     1860

catatcaagt cttcaaaaga ctttgatatc actttctgtc atgatctgat cgactacttc     1920

aaaaactgta ttgcaattca tcccgagtgg aaaaacttcg gttttgattt tagcgacacc     1980

agtacttatg aagacatttc cgggttttat cgtgaggtag agttacaagg ttacaagatt     2040

gattggacat acattagcga aaaagacatt gatctgctgc aggaaaaagg tcaactgtat     2100

ctgttccaga tatataacaa agatttttcg aaaaaatcaa ccgggaatga caaccttcac     2160

accatgtacc tgaaaaatct tttctcagaa gaaaatctta aggatatcgt cctgaaactt     2220

aacggcgaag cggaaatctt cttcaggaag agcagcataa agaacccaat cattcataaa     2280

aaaggctcga ttttagtcaa ccgtacctac gaagcagaag aaaaagacca gtttggcaac     2340

attcaaattg tgcgtaaaaa tattccggaa aacatttatc aggagctgta caaatacttc     2400

aacgataaaa gcgacaaaga gctgtctgat gaagcagcca aactgaagaa tgtagtggga     2460

caccacgagg cagcgacgaa tatagtcaag gactatcgct acacgtatga taaatacttc     2520

cttcatatgc ctattacgat caatttcaaa gccaataaaa cgggttttat taatgatagg     2580

atcttacagt atatcgctaa agaaaaagac ttacatgtga tcggcattga tcggggcgag     2640

cgtaacctga tctacgtgtc cgtgattgat acttgtggta atatagttga acagaaaagc     2700

tttaacattg taaacggcta cgactatcag ataaaactga aacaacagga gggcgctaga     2760

cagattgcgc ggaaagaatg gaaagaaatt ggtaaaatta aagagatcaa agagggctac     2820

ctgagcttag taatccacga gatctctaaa atggtaatca aatacaatgc aattatagcg     2880

atggaggatt tgtcttatgg ttttaaaaaa gggcgcttta aggtcgaacg gcaagtttac     2940

cagaaatttg aaaccatgct catcaataaa ctcaactatc tggtatttaa agatatttcg     3000

attaccgaga atggcggtct cctgaaaggt tatcagctga catacattcc tgataaactt     3060

aaaaacgtgg gtcatcagtg cggctgcatt ttttatgtgc ctgctgcata cacgagcaaa     3120

attgatccga ccaccggctt tgtgaatatc tttaaattta aagacctgac agtggacgca     3180

aaacgtgaat tcattaaaaa atttgactca attcgttatg acagtgaaaa aaatctgttc     3240

tgctttacat ttgactacaa taactttatt acgcaaaaca cggtcatgag caaatcatcg     3300

tggagtgtgt atacatacgg cgtgcgcatc aaacgtcgct ttgtgaacgg ccgcttctca     3360

aacgaaagtg ataccattga cataaccaaa gatatggaga aaacgttgga aatgacggac     3420

attaactggc gcgatggcca cgatcttcgt caagacatta tagattatga aattgttcag     3480

cacatattcg aaattttccg tttaacagtg caaatgcgta actccttgtc tgaactggag     3540

gaccgtgatt acgatcgtct catttcacct gtactgaacg aaaataacat tttttatgac     3600

agcgcgaaag cgggggatgc acttcctaag gatgccgatg caaatggtgc gtattgtatt     3660

gcattaaaag ggttatatga aattaaacaa attaccgaaa attggaaaga agatggtaaa     3720

ttttcgcgcg ataaactcaa aatcagcaat aaagattggt tcgactttat ccagaataag     3780

cgctatctct aa                                                         3792


