                         SEQUENCE LISTING

<110>  Lange, Rdiger; Krane, Markus; Dreen, Martina; Lahm, Harald; Doppler, Stefanie
 
<120>  Method of diagnosing heart muscle damage

<130>  P73950

<150>  EP18164958.3
<151>  2018-03-29

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  1372
<212>  DNA
<213>  Homo sapiens

<400>  1
accagcagtg aaaatctaga gctggagctc agcctctggg aaggcccagc atggaggcag       60

ccacagctcc ggaggtggcc gcaggatcca agctgaaggt gaaagaagcc agcccagcgg      120

atgctgaacc accccaggct tcacctggac agggggctgg cagccccact ccccagctcc      180

tgccccctat agaagagcac cccaagatct ggctacctcg ggccctgagg cagacctaca      240

tccggaaggt tggggacaca gtgaacctac taatcccatt ccagggcaag cccaaacctc      300

aagccatctg gacacatgat ggctgtgcct tggacaccag gcgtgtgagt gtgcggaatg      360

gggagcaaga ctccatcctc ttcatccgag aagcccaacg tgctgactca ggtcgctacc      420

aactccgcgt gcagctgggt gggctggagg ccaccgccac cattgacatc ctggtgattg      480

agaggccagg ccctcctcag agtattaagc tggtggacgt ttggggcttc agcgctacac      540

tggaatggac accgccccaa gatacgggga atacagcact tctgggatac acggtgcaga      600

aggctgacac aaaatccggg ctgtggttca cggtgctgga gcactatcac cgcaccagct      660

gcatcgtctc tgacctcatc atcggcaact cctatgcctt ccgtgtcttt gctgaaaacc      720

agtgcggact cagtgaaaca gcccccatca ctacggacct cgcccacatc cagaaagcag      780

ctactgttta caagaccaag gggtttgccc aacgagactt ctctgaagcc ccaaagttta      840

cccagcctct ggccgactgc actacagtca ccggctataa tacccagctc ttctgctgtg      900

tccgcgcctc tccccggccc aagatcatct ggctgaagaa caagatggat atccaaggca      960

accctaagta cagagccctg actcacctgg gaatctgctc cctagagatc cgcaagccgg     1020

gtccctttga tggaggcatc tatacctgca aggcggtgaa ccccctaggg gaggcatctg     1080

tggactgtcg ggtggatgtg aaagttccta attgaggaca cctaagaagg catggtactc     1140

tgacaaagcc agtgcccagc aatgaagtga attcatggca caggagccag ggaccgtgac     1200

aacggtgccc tcagcagcct ggtgtcctct ggccatttgc tgtcatggct acaaagtgct     1260

ccctcttttc agtgcctcca ggaagcccgc cagtggtgag actgtgtcct caaggagctt     1320

cggcaccatg tctggtttgg attcatctaa ataaatatgt ggttccccag tg             1372


<210>  2
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  2
atggaggcag ccacagctcc ggaggtggcc gcaggatcca agctgaaggt gaaagaagcc       60

agcccagcgg atgctgaacc accccaggct tcacctggac agggggctgg cagccccact      120

ccccagctcc tgccccctat agaagagcac cccaagatct ggctacctcg ggccctgagg      180

cagacctaca tccggaaggt tggggacaca gtgaacctac taatcccatt ccagggcaag      240

cccaaacctc aagccatctg gacacatgat ggctgtgcct tggacaccag gcgtgtgagt      300

gtgcggaatg gggagcaaga ctccatcctc ttcatccgag aagcccaacg tgctgactca      360

ggtcgctacc aactccgcgt gcagctgggt gggctggagg ccaccgccac cattgacatc      420

ctggtgattg agaggccagg ccctcctcag agtattaagc tggtggacgt ttggggcttc      480

agcgctacac tggaatggac accgccccaa gatacgggga atacagcact tctgggatac      540

acggtgcaga aggctgacac aaaatccggg ctgtggttca cggtgctgga gcactatcac      600

cgcaccagct gcatcgtctc tgacctcatc atcggcaact cctatgcctt ccgtgtcttt      660

gctgaaaacc agtgcggact cagtgaaaca gcccccatca ctacggacct cgcccacatc      720

cagaaagcag ctactgttta caagaccaag gggtttgccc aacgagactt ctctgaagcc      780

ccaaagttta cccagcctct ggccgactgc actacagtca ccggctataa tacccagctc      840

ttctgctgtg tccgcgcctc tccccggccc aagatcatct ggctgaagaa caagatggat      900

atccaaggca accctaagta cagagccctg actcacctgg gaatctgctc cctagagatc      960

cgcaagccgg gtccctttga tggaggcatc tatacctgca aggcggtgaa ccccctaggg     1020

gaggcatctg tggactgtcg ggtggatgtg aaagttccta attga                     1065


<210>  3
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Ala Ala Thr Ala Pro Glu Val Ala Ala Gly Ser Lys Leu Lys 
1               5                   10                  15      


Val Lys Glu Ala Ser Pro Ala Asp Ala Glu Pro Pro Gln Ala Ser Pro 
            20                  25                  30          


Gly Gln Gly Ala Gly Ser Pro Thr Pro Gln Leu Leu Pro Pro Ile Glu 
        35                  40                  45              


Glu His Pro Lys Ile Trp Leu Pro Arg Ala Leu Arg Gln Thr Tyr Ile 
    50                  55                  60                  


Arg Lys Val Gly Asp Thr Val Asn Leu Leu Ile Pro Phe Gln Gly Lys 
65                  70                  75                  80  


Pro Lys Pro Gln Ala Ile Trp Thr His Asp Gly Cys Ala Leu Asp Thr 
                85                  90                  95      


Arg Arg Val Ser Val Arg Asn Gly Glu Gln Asp Ser Ile Leu Phe Ile 
            100                 105                 110         


Arg Glu Ala Gln Arg Ala Asp Ser Gly Arg Tyr Gln Leu Arg Val Gln 
        115                 120                 125             


Leu Gly Gly Leu Glu Ala Thr Ala Thr Ile Asp Ile Leu Val Ile Glu 
    130                 135                 140                 


Arg Pro Gly Pro Pro Gln Ser Ile Lys Leu Val Asp Val Trp Gly Phe 
145                 150                 155                 160 


Ser Ala Thr Leu Glu Trp Thr Pro Pro Gln Asp Thr Gly Asn Thr Ala 
                165                 170                 175     


Leu Leu Gly Tyr Thr Val Gln Lys Ala Asp Thr Lys Ser Gly Leu Trp 
            180                 185                 190         


Phe Thr Val Leu Glu His Tyr His Arg Thr Ser Cys Ile Val Ser Asp 
        195                 200                 205             


Leu Ile Ile Gly Asn Ser Tyr Ala Phe Arg Val Phe Ala Glu Asn Gln 
    210                 215                 220                 


Cys Gly Leu Ser Glu Thr Ala Pro Ile Thr Thr Asp Leu Ala His Ile 
225                 230                 235                 240 


Gln Lys Ala Ala Thr Val Tyr Lys Thr Lys Gly Phe Ala Gln Arg Asp 
                245                 250                 255     


Phe Ser Glu Ala Pro Lys Phe Thr Gln Pro Leu Ala Asp Cys Thr Thr 
            260                 265                 270         


Val Thr Gly Tyr Asn Thr Gln Leu Phe Cys Cys Val Arg Ala Ser Pro 
        275                 280                 285             


Arg Pro Lys Ile Ile Trp Leu Lys Asn Lys Met Asp Ile Gln Gly Asn 
    290                 295                 300                 


Pro Lys Tyr Arg Ala Leu Thr His Leu Gly Ile Cys Ser Leu Glu Ile 
305                 310                 315                 320 


Arg Lys Pro Gly Pro Phe Asp Gly Gly Ile Tyr Thr Cys Lys Ala Val 
                325                 330                 335     


Asn Pro Leu Gly Glu Ala Ser Val Asp Cys Arg Val Asp Val Lys Val 
            340                 345                 350         


Pro Asn 
        


<210>  4
<211>  1303
<212>  DNA
<213>  Homo sapiens

<400>  4
accagcagtg aaaatctaga gctggagctc agcctctggg aaggcccagc atggaggcag       60

ccacagctcc ggaggtggcc gcaggatcca agctgaaggt gaaagaagcc agcccagcgg      120

atgctgaacc accccaggct tcacctggac agggggctgg cagccccact ccccagctcc      180

tgccccctat agaagagcac cccaagatct ggctacctcg ggccctgagg cagacctaca      240

tccggaaggt tggggacaca gtgaacctac taatcccatt ccagggcaag cccaaacctc      300

aagccatctg gacacatgat ggctgtgcct tggacaccag gcgtgtgagt gtgcggaatg      360

gggagcaaga ctccatcctc ttcatccgag aagcccaacg tgctgactca gagaggccag      420

gccctcctca gagtattaag ctggtggacg tttggggctt cagcgctaca ctggaatgga      480

caccgcccca agatacgggg aatacagcac ttctgggata cacggtgcag aaggctgaca      540

caaaatccgg gctgtggttc acggtgctgg agcactatca ccgcaccagc tgcatcgtct      600

ctgacctcat catcggcaac tcctatgcct tccgtgtctt tgctgaaaac cagtgcggac      660

tcagtgaaac agcccccatc actacggacc tcgcccacat ccagaaagca gctactgttt      720

acaagaccaa ggggtttgcc caacgagact tctctgaagc cccaaagttt acccagcctc      780

tggccgactg cactacagtc accggctata atacccagct cttctgctgt gtccgcgcct      840

ctccccggcc caagatcatc tggctgaaga acaagatgga tatccaaggc aaccctaagt      900

acagagccct gactcacctg ggaatctgct ccctagagat ccgcaagccg ggtccctttg      960

atggaggcat ctatacctgc aaggcggtga accccctagg ggaggcatct gtggactgtc     1020

gggtggatgt gaaagttcct aattgaggac acctaagaag gcatggtact ctgacaaagc     1080

cagtgcccag caatgaagtg aattcatggc acaggagcca gggaccgtga caacggtgcc     1140

ctcagcagcc tggtgtcctc tggccatttg ctgtcatggc tacaaagtgc tccctctttt     1200

cagtgcctcc aggaagcccg ccagtggtga gactgtgtcc tcaaggagct tcggcaccat     1260

gtctggtttg gattcatcta aataaatatg tggttcccca gtg                       1303


<210>  5
<211>  996
<212>  DNA
<213>  Homo sapiens

<400>  5
atggaggcag ccacagctcc ggaggtggcc gcaggatcca agctgaaggt gaaagaagcc       60

agcccagcgg atgctgaacc accccaggct tcacctggac agggggctgg cagccccact      120

ccccagctcc tgccccctat agaagagcac cccaagatct ggctacctcg ggccctgagg      180

cagacctaca tccggaaggt tggggacaca gtgaacctac taatcccatt ccagggcaag      240

cccaaacctc aagccatctg gacacatgat ggctgtgcct tggacaccag gcgtgtgagt      300

gtgcggaatg gggagcaaga ctccatcctc ttcatccgag aagcccaacg tgctgactca      360

gagaggccag gccctcctca gagtattaag ctggtggacg tttggggctt cagcgctaca      420

ctggaatgga caccgcccca agatacgggg aatacagcac ttctgggata cacggtgcag      480

aaggctgaca caaaatccgg gctgtggttc acggtgctgg agcactatca ccgcaccagc      540

tgcatcgtct ctgacctcat catcggcaac tcctatgcct tccgtgtctt tgctgaaaac      600

cagtgcggac tcagtgaaac agcccccatc actacggacc tcgcccacat ccagaaagca      660

gctactgttt acaagaccaa ggggtttgcc caacgagact tctctgaagc cccaaagttt      720

acccagcctc tggccgactg cactacagtc accggctata atacccagct cttctgctgt      780

gtccgcgcct ctccccggcc caagatcatc tggctgaaga acaagatgga tatccaaggc      840

aaccctaagt acagagccct gactcacctg ggaatctgct ccctagagat ccgcaagccg      900

ggtccctttg atggaggcat ctatacctgc aaggcggtga accccctagg ggaggcatct      960

gtggactgtc gggtggatgt gaaagttcct aattga                                996


<210>  6
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Ala Ala Thr Ala Pro Glu Val Ala Ala Gly Ser Lys Leu Lys 
1               5                   10                  15      


Val Lys Glu Ala Ser Pro Ala Asp Ala Glu Pro Pro Gln Ala Ser Pro 
            20                  25                  30          


Gly Gln Gly Ala Gly Ser Pro Thr Pro Gln Leu Leu Pro Pro Ile Glu 
        35                  40                  45              


Glu His Pro Lys Ile Trp Leu Pro Arg Ala Leu Arg Gln Thr Tyr Ile 
    50                  55                  60                  


Arg Lys Val Gly Asp Thr Val Asn Leu Leu Ile Pro Phe Gln Gly Lys 
65                  70                  75                  80  


Pro Lys Pro Gln Ala Ile Trp Thr His Asp Gly Cys Ala Leu Asp Thr 
                85                  90                  95      


Arg Arg Val Ser Val Arg Asn Gly Glu Gln Asp Ser Ile Leu Phe Ile 
            100                 105                 110         


Arg Glu Ala Gln Arg Ala Asp Ser Glu Arg Pro Gly Pro Pro Gln Ser 
        115                 120                 125             


Ile Lys Leu Val Asp Val Trp Gly Phe Ser Ala Thr Leu Glu Trp Thr 
    130                 135                 140                 


Pro Pro Gln Asp Thr Gly Asn Thr Ala Leu Leu Gly Tyr Thr Val Gln 
145                 150                 155                 160 


Lys Ala Asp Thr Lys Ser Gly Leu Trp Phe Thr Val Leu Glu His Tyr 
                165                 170                 175     


His Arg Thr Ser Cys Ile Val Ser Asp Leu Ile Ile Gly Asn Ser Tyr 
            180                 185                 190         


Ala Phe Arg Val Phe Ala Glu Asn Gln Cys Gly Leu Ser Glu Thr Ala 
        195                 200                 205             


Pro Ile Thr Thr Asp Leu Ala His Ile Gln Lys Ala Ala Thr Val Tyr 
    210                 215                 220                 


Lys Thr Lys Gly Phe Ala Gln Arg Asp Phe Ser Glu Ala Pro Lys Phe 
225                 230                 235                 240 


Thr Gln Pro Leu Ala Asp Cys Thr Thr Val Thr Gly Tyr Asn Thr Gln 
                245                 250                 255     


Leu Phe Cys Cys Val Arg Ala Ser Pro Arg Pro Lys Ile Ile Trp Leu 
            260                 265                 270         


Lys Asn Lys Met Asp Ile Gln Gly Asn Pro Lys Tyr Arg Ala Leu Thr 
        275                 280                 285             


His Leu Gly Ile Cys Ser Leu Glu Ile Arg Lys Pro Gly Pro Phe Asp 
    290                 295                 300                 


Gly Gly Ile Tyr Thr Cys Lys Ala Val Asn Pro Leu Gly Glu Ala Ser 
305                 310                 315                 320 


Val Asp Cys Arg Val Asp Val Lys Val Pro Asn 
                325                 330     


<210>  7
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Met Glu Lys Asn Thr Ser Glu Gly Pro Ala Cys Ser Pro Glu Glu 
1               5                   10                  15      


Thr Ala Ser Glu Ser Ala Lys Val Pro Thr Ala Glu Pro Pro Gly Glu 
            20                  25                  30          


Val Ala Val Ser Glu Ser Thr Arg Glu Glu Gln Val Pro Lys Pro Gln 
        35                  40                  45              


Ala Pro Ala Pro Gln Ala Pro Thr Ala Ser Thr Ala Thr Lys Pro Ala 
    50                  55                  60                  


Pro Pro Ser Glu Asp Val Pro Ser Ala Pro Leu Leu Leu Thr Leu Asp 
65                  70                  75                  80  


Asp Val Ser Ser Ser Ser Val Thr Val Ser Trp Glu Pro Pro Glu Arg 
                85                  90                  95      


Leu Gly Arg Leu Gly Leu Gln Gly Tyr Val Leu Glu Leu Cys Arg Glu 
            100                 105                 110         


Gly Ala Ser Glu Trp Val Pro Val Ser Ala Arg Pro Met Met Val Thr 
        115                 120                 125             


Gln Gln Thr Val Arg Asn Leu Ala Leu Gly Asp Lys Phe Leu Leu Arg 
    130                 135                 140                 


Val Ser Ala Val Ser Ser Ala Gly Ala Gly Pro Pro Ala Met Leu Asp 
145                 150                 155                 160 


Gln Pro Ile His Ile Arg Glu Asn Ile Glu Ala Pro Lys Ile Arg Val 
                165                 170                 175     


Pro Arg His Leu Arg Gln Thr Tyr Ile Arg Gln Val Gly Glu Thr Val 
            180                 185                 190         


Asn Leu Gln Ile Pro Phe Gln Gly Lys Pro Lys Pro Gln Ala Thr Trp 
        195                 200                 205             


Thr His Asn Gly His Ala Leu Asp Ser Gln Arg Val Ser Met Arg Thr 
    210                 215                 220                 


Gly Asp Gln Asp Ser Ile Leu Phe Ile Arg Ser Ala Gln Arg Ser Asp 
225                 230                 235                 240 


Ser Gly Arg Tyr Glu Leu Thr Val Arg Val Glu Asp Leu Glu Ala Lys 
                245                 250                 255     


Ala Val Ile Asp Ile Leu Val Ile Glu Lys Pro Gly Pro Pro Ser Ser 
            260                 265                 270         


Ile Arg Leu Leu Asp Val Trp Gly Cys Asn Ala Ala Leu Gln Trp Thr 
        275                 280                 285             


Pro Pro Gln Asp Thr Gly Asn Thr Glu Leu Leu Gly Tyr Met Val Gln 
    290                 295                 300                 


Lys Ala Asp Lys Lys Thr Gly Gln Trp Phe Thr Val Leu Glu Arg Tyr 
305                 310                 315                 320 


His Pro Thr Thr Cys Thr Ile Ser Asp Leu Ile Ile Gly Asn Ser Tyr 
                325                 330                 335     


Ser Phe Arg Val Phe Ser Glu Asn Leu Cys Gly Leu Ser Thr Ser Ala 
            340                 345                 350         


Thr Val Thr Lys Glu Leu Ala His Ile Gln Lys Ala Asp Ile Ala Ala 
        355                 360                 365             


Lys Pro Lys Gly Phe Ile Glu Arg Asp Phe Ser Glu Ala Pro Ser Phe 
    370                 375                 380                 


Thr Gln Pro Leu Ala Asp His Thr Ser Thr Pro Gly Tyr Ser Thr Gln 
385                 390                 395                 400 


Leu Phe Cys Ser Val Arg Ala Ser Pro Lys Pro Lys Ile Ile Trp Met 
                405                 410                 415     


Lys Asn Lys Met Glu Ile Gln Gly Asn Pro Lys Tyr Arg Ala Leu Ser 
            420                 425                 430         


Glu Gln Gly Val Cys Thr Leu Glu Ile Arg Lys Pro Ser Pro Phe Asp 
        435                 440                 445             


Ser Gly Val Tyr Thr Cys Lys Ala Ile Asn Val Leu Gly Glu Ala Ser 
    450                 455                 460                 


Val Asp Cys Arg Leu Glu Val Lys Ala Ser Ala Ala His 
465                 470                 475         


<210>  8
<211>  1877
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Gly Ser Ser Val Lys Ser Val Gln Pro Glu Val Glu Leu Ser 
1               5                   10                  15      


Ser Gly Gly Gly Asp Glu Gly Ala Asp Glu Pro Arg Gly Ala Gly Arg 
            20                  25                  30          


Lys Ala Ala Ala Ala Asp Gly Arg Gly Met Leu Pro Lys Arg Ala Lys 
        35                  40                  45              


Ala Pro Gly Gly Gly Gly Gly Met Ala Lys Ala Ser Ala Ala Glu Leu 
    50                  55                  60                  


Lys Val Phe Lys Ser Gly Ser Val Asp Ser Arg Val Pro Gly Gly Pro 
65                  70                  75                  80  


Pro Ala Ser Asn Leu Arg Lys Gln Lys Ser Leu Thr Asn Leu Ser Phe 
                85                  90                  95      


Leu Thr Asp Ser Glu Lys Lys Leu Gln Leu Tyr Glu Pro Glu Trp Ser 
            100                 105                 110         


Asp Asp Met Ala Lys Ala Pro Lys Gly Leu Gly Lys Val Gly Ser Lys 
        115                 120                 125             


Gly Arg Glu Ala Pro Leu Met Ser Lys Thr Leu Ser Lys Ser Glu His 
    130                 135                 140                 


Ser Leu Phe Gln Ala Lys Gly Ser Pro Ala Gly Gly Ala Lys Thr Pro 
145                 150                 155                 160 


Leu Ala Pro Leu Ala Pro Asn Leu Gly Lys Pro Ser Arg Ile Pro Arg 
                165                 170                 175     


Gly Pro Tyr Ala Glu Val Lys Pro Leu Ser Lys Ala Pro Glu Ala Ala 
            180                 185                 190         


Val Ser Glu Asp Gly Lys Ser Asp Asp Glu Leu Leu Ser Ser Lys Ala 
        195                 200                 205             


Lys Ala Gln Lys Ser Ser Gly Pro Val Pro Ser Ala Lys Gly Gln Glu 
    210                 215                 220                 


Glu Arg Ala Phe Leu Lys Val Asp Pro Glu Leu Val Val Thr Val Leu 
225                 230                 235                 240 


Gly Asp Leu Glu Gln Leu Leu Phe Ser Gln Met Leu Asp Pro Glu Ser 
                245                 250                 255     


Gln Arg Lys Arg Thr Val Gln Asn Val Leu Asp Leu Arg Gln Asn Leu 
            260                 265                 270         


Glu Glu Thr Met Ser Ser Leu Arg Gly Ser Gln Val Thr His Ser Ser 
        275                 280                 285             


Leu Glu Met Thr Cys Tyr Asp Ser Asp Asp Ala Asn Pro Arg Ser Val 
    290                 295                 300                 


Ser Ser Leu Ser Asn Arg Ser Ser Pro Leu Ser Trp Arg Tyr Gly Gln 
305                 310                 315                 320 


Ser Ser Pro Arg Leu Gln Ala Gly Asp Ala Pro Ser Val Gly Gly Ser 
                325                 330                 335     


Cys Arg Ser Glu Gly Thr Pro Ala Trp Tyr Met His Gly Glu Arg Ala 
            340                 345                 350         


His Tyr Ser His Thr Met Pro Met Arg Ser Pro Ser Lys Leu Ser His 
        355                 360                 365             


Ile Ser Arg Leu Glu Leu Val Glu Ser Leu Asp Ser Asp Glu Val Asp 
    370                 375                 380                 


Leu Lys Ser Gly Tyr Met Ser Asp Ser Asp Leu Met Gly Lys Thr Met 
385                 390                 395                 400 


Thr Glu Asp Asp Asp Ile Thr Thr Gly Trp Asp Glu Ser Ser Ser Ile 
                405                 410                 415     


Ser Ser Gly Leu Ser Asp Ala Ser Asp Asn Leu Ser Ser Glu Glu Phe 
            420                 425                 430         


Asn Ala Ser Ser Ser Leu Asn Ser Leu Pro Ser Thr Pro Thr Ala Ser 
        435                 440                 445             


Arg Arg Asn Ser Thr Ile Val Leu Arg Thr Asp Ser Glu Lys Arg Ser 
    450                 455                 460                 


Leu Ala Glu Ser Gly Leu Ser Trp Phe Ser Glu Ser Glu Glu Lys Ala 
465                 470                 475                 480 


Pro Lys Lys Leu Glu Tyr Asp Ser Gly Ser Leu Lys Met Glu Pro Gly 
                485                 490                 495     


Thr Ser Lys Trp Arg Arg Glu Arg Pro Glu Ser Cys Asp Asp Ser Ser 
            500                 505                 510         


Lys Gly Gly Glu Leu Lys Lys Pro Ile Ser Leu Gly His Pro Gly Ser 
        515                 520                 525             


Leu Lys Lys Gly Lys Thr Pro Pro Val Ala Val Thr Ser Pro Ile Thr 
    530                 535                 540                 


His Thr Ala Gln Ser Ala Leu Lys Val Ala Gly Lys Pro Glu Gly Lys 
545                 550                 555                 560 


Ala Thr Asp Lys Gly Lys Leu Ala Val Lys Asn Thr Gly Leu Gln Arg 
                565                 570                 575     


Ser Ser Ser Asp Ala Gly Arg Asp Arg Leu Ser Asp Ala Lys Lys Pro 
            580                 585                 590         


Pro Ser Gly Ile Ala Arg Pro Ser Thr Ser Gly Ser Phe Gly Tyr Lys 
        595                 600                 605             


Lys Pro Pro Pro Ala Thr Gly Thr Ala Thr Val Met Gln Thr Gly Gly 
    610                 615                 620                 


Ser Ala Thr Leu Ser Lys Ile Gln Lys Ser Ser Gly Ile Pro Val Lys 
625                 630                 635                 640 


Pro Val Asn Gly Arg Lys Thr Ser Leu Asp Val Ser Asn Ser Ala Glu 
                645                 650                 655     


Pro Gly Phe Leu Ala Pro Gly Ala Arg Ser Asn Ile Gln Tyr Arg Ser 
            660                 665                 670         


Leu Pro Arg Pro Ala Lys Ser Ser Ser Met Ser Val Thr Gly Gly Arg 
        675                 680                 685             


Gly Gly Pro Arg Pro Val Ser Ser Ser Ile Asp Pro Ser Leu Leu Ser 
    690                 695                 700                 


Thr Lys Gln Gly Gly Leu Thr Pro Ser Arg Leu Lys Glu Pro Thr Lys 
705                 710                 715                 720 


Val Ala Ser Gly Arg Thr Thr Pro Ala Pro Val Asn Gln Thr Asp Arg 
                725                 730                 735     


Glu Lys Glu Lys Ala Lys Ala Lys Ala Val Ala Leu Asp Ser Asp Asn 
            740                 745                 750         


Ile Ser Leu Lys Ser Ile Gly Ser Pro Glu Ser Thr Pro Lys Asn Gln 
        755                 760                 765             


Ala Ser His Pro Thr Ala Thr Lys Leu Ala Glu Leu Pro Pro Thr Pro 
    770                 775                 780                 


Leu Arg Ala Thr Ala Lys Ser Phe Val Lys Pro Pro Ser Leu Ala Asn 
785                 790                 795                 800 


Leu Asp Lys Val Asn Ser Asn Ser Leu Asp Leu Pro Ser Ser Ser Asp 
                805                 810                 815     


Thr Thr His Ala Ser Lys Val Pro Asp Leu His Ala Thr Ser Ser Ala 
            820                 825                 830         


Ser Gly Gly Pro Leu Pro Ser Cys Phe Thr Pro Ser Pro Ala Pro Ile 
        835                 840                 845             


Leu Asn Ile Asn Ser Ala Ser Phe Ser Gln Gly Leu Glu Leu Met Ser 
    850                 855                 860                 


Gly Phe Ser Val Pro Lys Glu Thr Arg Met Tyr Pro Lys Leu Ser Gly 
865                 870                 875                 880 


Leu His Arg Ser Met Glu Ser Leu Gln Met Pro Met Ser Leu Pro Ser 
                885                 890                 895     


Ala Phe Pro Ser Ser Thr Pro Val Pro Thr Pro Pro Ala Pro Pro Ala 
            900                 905                 910         


Ala Pro Thr Glu Glu Glu Thr Glu Glu Leu Thr Trp Ser Gly Ser Pro 
        915                 920                 925             


Arg Ala Gly Gln Leu Asp Ser Asn Gln Arg Asp Arg Asn Thr Leu Pro 
    930                 935                 940                 


Lys Lys Gly Leu Arg Tyr Gln Leu Gln Ser Gln Glu Glu Thr Lys Glu 
945                 950                 955                 960 


Arg Arg His Ser His Thr Ile Gly Gly Leu Pro Glu Ser Asp Asp Gln 
                965                 970                 975     


Ser Glu Leu Pro Ser Pro Pro Ala Leu Pro Met Ser Leu Ser Ala Lys 
            980                 985                 990         


Gly Gln Leu Thr Asn Ile Val Ser  Pro Thr Ala Ala Thr  Thr Pro Arg 
        995                 1000                 1005             


Ile Thr  Arg Ser Asn Ser Ile  Pro Thr His Glu Ala  Ala Phe Glu 
    1010                 1015                 1020             


Leu Tyr  Ser Gly Ser Gln Met  Gly Ser Thr Leu Ser  Leu Ala Glu 
    1025                 1030                 1035             


Arg Pro  Lys Gly Met Ile Arg  Ser Gly Ser Phe Arg  Asp Pro Thr 
    1040                 1045                 1050             


Asp Asp  Val His Gly Ser Val  Leu Ser Leu Ala Ser  Ser Ala Ser 
    1055                 1060                 1065             


Ser Thr  Tyr Ser Ser Ala Glu  Glu Arg Met Gln Ser  Glu Gln Ile 
    1070                 1075                 1080             


Arg Lys  Leu Arg Arg Glu Leu  Glu Ser Ser Gln Glu  Lys Val Ala 
    1085                 1090                 1095             


Thr Leu  Thr Ser Gln Leu Ser  Ala Asn Ala Asn Leu  Val Ala Ala 
    1100                 1105                 1110             


Phe Glu  Gln Ser Leu Val Asn  Met Thr Ser Arg Leu  Arg His Leu 
    1115                 1120                 1125             


Ala Glu  Thr Ala Glu Glu Lys  Asp Thr Glu Leu Leu  Asp Leu Arg 
    1130                 1135                 1140             


Glu Thr  Ile Asp Phe Leu Lys  Lys Lys Asn Ser Glu  Ala Gln Ala 
    1145                 1150                 1155             


Val Ile  Gln Gly Ala Leu Asn  Ala Ser Glu Thr Thr  Pro Lys Glu 
    1160                 1165                 1170             


Leu Arg  Ile Lys Arg Gln Asn  Ser Ser Asp Ser Ile  Ser Ser Leu 
    1175                 1180                 1185             


Asn Ser  Ile Thr Ser His Ser  Ser Ile Gly Ser Ser  Lys Asp Ala 
    1190                 1195                 1200             


Asp Ala  Lys Lys Lys Lys Lys  Lys Ser Trp Val Tyr  Glu Leu Arg 
    1205                 1210                 1215             


Ser Ser  Phe Asn Lys Ala Phe  Ser Ile Lys Lys Gly  Pro Lys Ser 
    1220                 1225                 1230             


Ala Ser  Ser Tyr Ser Asp Ile  Glu Glu Ile Ala Thr  Pro Asp Ser 
    1235                 1240                 1245             


Ser Ala  Pro Ser Ser Pro Lys  Leu Gln His Gly Ser  Thr Glu Thr 
    1250                 1255                 1260             


Ala Ser  Pro Ser Ile Lys Ser  Ser Thr Ser Ser Ser  Val Gly Thr 
    1265                 1270                 1275             


Asp Val  Thr Glu Gly Pro Ala  His Pro Ala Pro His  Thr Arg Leu 
    1280                 1285                 1290             


Phe His  Ala Asn Glu Glu Glu  Glu Pro Glu Lys Lys  Glu Val Ser 
    1295                 1300                 1305             


Glu Leu  Arg Ser Glu Leu Trp  Glu Lys Glu Met Lys  Leu Thr Asp 
    1310                 1315                 1320             


Ile Arg  Leu Glu Ala Leu Asn  Ser Ala His Gln Leu  Asp Gln Leu 
    1325                 1330                 1335             


Arg Glu  Thr Met His Asn Met  Gln Leu Glu Val Asp  Leu Leu Lys 
    1340                 1345                 1350             


Ala Glu  Asn Asp Arg Leu Lys  Val Ala Pro Gly Pro  Ser Ser Gly 
    1355                 1360                 1365             


Ser Thr  Pro Gly Gln Val Pro  Gly Ser Ser Ala Leu  Ser Ser Pro 
    1370                 1375                 1380             


Arg Arg  Ser Leu Gly Leu Ala  Leu Thr His Ser Phe  Gly Pro Ser 
    1385                 1390                 1395             


Leu Ala  Asp Thr Asp Leu Ser  Pro Met Asp Gly Ile  Ser Thr Cys 
    1400                 1405                 1410             


Gly Pro  Lys Glu Glu Val Thr  Leu Arg Val Val Val  Arg Met Pro 
    1415                 1420                 1425             


Pro Gln  His Ile Ile Lys Gly  Asp Leu Lys Gln Gln  Glu Phe Phe 
    1430                 1435                 1440             


Leu Gly  Cys Ser Lys Val Ser  Gly Lys Val Asp Trp  Lys Met Leu 
    1445                 1450                 1455             


Asp Glu  Ala Val Phe Gln Val  Phe Lys Asp Tyr Ile  Ser Lys Met 
    1460                 1465                 1470             


Asp Pro  Ala Ser Thr Leu Gly  Leu Ser Thr Glu Ser  Ile His Gly 
    1475                 1480                 1485             


Tyr Ser  Ile Ser His Val Lys  Arg Val Leu Asp Ala  Glu Pro Pro 
    1490                 1495                 1500             


Glu Met  Pro Pro Cys Arg Arg  Gly Val Asn Asn Ile  Ser Val Ser 
    1505                 1510                 1515             


Leu Lys  Gly Leu Lys Glu Lys  Cys Val Asp Ser Leu  Val Phe Glu 
    1520                 1525                 1530             


Thr Leu  Ile Pro Lys Pro Met  Met Gln His Tyr Ile  Ser Leu Leu 
    1535                 1540                 1545             


Leu Lys  His Arg Arg Leu Val  Leu Ser Gly Pro Ser  Gly Thr Gly 
    1550                 1555                 1560             


Lys Thr  Tyr Leu Thr Asn Arg  Leu Ala Glu Tyr Leu  Val Glu Arg 
    1565                 1570                 1575             


Ser Gly  Arg Glu Val Thr Glu  Gly Ile Val Ser Thr  Phe Asn Met 
    1580                 1585                 1590             


His Gln  Gln Ser Cys Lys Asp  Leu Gln Leu Tyr Leu  Ser Asn Leu 
    1595                 1600                 1605             


Ala Asn  Gln Ile Asp Arg Glu  Thr Gly Ile Gly Asp  Val Pro Leu 
    1610                 1615                 1620             


Val Ile  Leu Leu Asp Asp Leu  Ser Glu Ala Gly Ser  Ile Ser Glu 
    1625                 1630                 1635             


Leu Val  Asn Gly Ala Leu Thr  Cys Lys Tyr His Lys  Cys Pro Tyr 
    1640                 1645                 1650             


Ile Ile  Gly Thr Thr Asn Gln  Pro Val Lys Met Thr  Pro Asn His 
    1655                 1660                 1665             


Gly Leu  His Leu Ser Phe Arg  Met Leu Thr Phe Ser  Asn Asn Val 
    1670                 1675                 1680             


Glu Pro  Ala Asn Gly Phe Leu  Val Arg Tyr Leu Arg  Arg Lys Leu 
    1685                 1690                 1695             


Val Glu  Ser Asp Ser Asp Ile  Asn Ala Asn Lys Glu  Glu Leu Leu 
    1700                 1705                 1710             


Arg Val  Leu Asp Trp Val Pro  Lys Leu Trp Tyr His  Leu His Thr 
    1715                 1720                 1725             


Phe Leu  Glu Lys His Ser Thr  Ser Asp Phe Leu Ile  Gly Pro Cys 
    1730                 1735                 1740             


Phe Phe  Leu Ser Cys Pro Ile  Gly Ile Glu Asp Phe  Arg Thr Trp 
    1745                 1750                 1755             


Phe Ile  Asp Leu Trp Asn Asn  Ser Ile Ile Pro Tyr  Leu Gln Glu 
    1760                 1765                 1770             


Gly Ala  Lys Asp Gly Ile Lys  Val His Gly Gln Lys  Ala Ala Trp 
    1775                 1780                 1785             


Glu Asp  Pro Val Glu Trp Val  Arg Asp Thr Leu Pro  Trp Pro Ser 
    1790                 1795                 1800             


Ala Gln  Gln Asp Gln Ser Lys  Leu Tyr His Leu Pro  Pro Pro Thr 
    1805                 1810                 1815             


Val Gly  Pro His Ser Ile Ala  Ser Pro Pro Glu Asp  Arg Thr Val 
    1820                 1825                 1830             


Lys Asp  Ser Thr Pro Ser Ser  Leu Asp Ser Asp Pro  Leu Met Ala 
    1835                 1840                 1845             


Met Leu  Leu Lys Leu Gln Glu  Ala Ala Asn Tyr Ile  Glu Ser Pro 
    1850                 1855                 1860             


Asp Arg  Glu Thr Ile Leu Asp  Pro Asn Leu Gln Ala  Thr Leu 
    1865                 1870                 1875         


<210>  9
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Phe Asn Tyr Glu Arg Pro Lys His Phe Ile Gln Ser Gln Asn Pro 
1               5                   10                  15      


Cys Gly Ser Arg Leu Gln Pro Pro Gly Pro Glu Thr Ser Ser Phe Ser 
            20                  25                  30          


Ser Gln Thr Lys Gln Ser Ser Ile Ile Ile Gln Pro Arg Gln Cys Thr 
        35                  40                  45              


Glu Gln Arg Phe Ser Ala Ser Ser Thr Leu Ser Ser His Ile Thr Met 
    50                  55                  60                  


Ser Ser Ser Ala Phe Pro Ala Ser Pro Lys Gln His Ala Gly Ser Asn 
65                  70                  75                  80  


Pro Gly Gln Arg Val Thr Thr Thr Tyr Asn Gln Ser Pro Ala Ser Phe 
                85                  90                  95      


Leu Ser Ser Ile Leu Pro Ser Gln Pro Asp Tyr Asn Ser Ser Lys Ile 
            100                 105                 110         


Pro Ser Ala Met Asp Ser Asn Tyr Gln Gln Ser Ser Ala Gly Gln Pro 
        115                 120                 125             


Ile Asn Ala Lys Pro Ser Gln Thr Ala Asn Ala Lys Pro Ile Pro Arg 
    130                 135                 140                 


Thr Pro Asp His Glu Ile Gln Gly Ser Lys Glu Ala Leu Ile Gln Asp 
145                 150                 155                 160 


Leu Glu Arg Lys Leu Lys Cys Lys Asp Thr Leu Leu His Asn Gly Asn 
                165                 170                 175     


Gln Arg Leu Thr Tyr Glu Glu Lys Met Ala Arg Arg Leu Leu Gly Pro 
            180                 185                 190         


Gln Asn Ala Ala Ala Val Phe Gln Ala Gln Asp Asp Ser Gly Ala Gln 
        195                 200                 205             


Asp Ser Gln Gln His Asn Ser Glu His Ala Arg Leu Gln Val Pro Thr 
    210                 215                 220                 


Ser Gln Val Arg Ser Arg Ser Thr Ser Arg Gly Asp Val Asn Asp Gln 
225                 230                 235                 240 


Asp Ala Ile Gln Glu Lys Phe Tyr Pro Pro Arg Phe Ile Gln Val Pro 
                245                 250                 255     


Glu Asn Met Ser Ile Asp Glu Gly Arg Phe Cys Arg Met Asp Phe Lys 
            260                 265                 270         


Val Ser Gly Leu Pro Ala Pro Asp Val Ser Trp Tyr Leu Asn Gly Arg 
        275                 280                 285             


Thr Val Gln Ser Asp Asp Leu His Lys Met Ile Val Ser Glu Lys Gly 
    290                 295                 300                 


Leu His Ser Leu Ile Phe Glu Val Val Arg Ala Ser Asp Ala Gly Ala 
305                 310                 315                 320 


Tyr Ala Cys Val Ala Lys Asn Arg Ala Gly Glu Ala Thr Phe Thr Val 
                325                 330                 335     


Gln Leu Asp Val Leu Ala Lys Glu His Lys Arg Ala Pro Met Phe Ile 
            340                 345                 350         


Tyr Lys Pro Gln Ser Lys Lys Val Leu Glu Gly Asp Ser Val Lys Leu 
        355                 360                 365             


Glu Cys Gln Ile Ser Ala Ile Pro Pro Pro Lys Leu Phe Trp Lys Arg 
    370                 375                 380                 


Asn Asn Glu Met Val Gln Phe Asn Thr Asp Arg Ile Ser Leu Tyr Gln 
385                 390                 395                 400 


Asp Asn Thr Gly Arg Val Thr Leu Leu Ile Lys Asp Val Asn Lys Lys 
                405                 410                 415     


Asp Ala Gly Trp Tyr Thr Val Ser Ala Val Asn Glu Ala Gly Val Thr 
            420                 425                 430         


Thr Cys Asn Thr Arg Leu Asp Val Thr Ala Arg Pro Asn Gln Thr Leu 
        435                 440                 445             


Pro Ala Pro Lys Gln Leu Arg Val Arg Pro Thr Phe Ser Lys Tyr Leu 
    450                 455                 460                 


Ala Leu Asn Gly Lys Gly Leu Asn Val Lys Gln Ala Phe Asn Pro Glu 
465                 470                 475                 480 


Gly Glu Phe Gln Arg Leu Ala Ala Gln Ser Gly Leu Tyr Glu Ser Glu 
                485                 490                 495     


Glu Leu 
        


<210>  10
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Cys Gly Ile Cys Cys Ser Val Asn Phe Ser Ala Glu His Phe Ser 
1               5                   10                  15      


Gln Asp Leu Lys Glu Asp Leu Leu Tyr Asn Leu Lys Gln Arg Gly Pro 
            20                  25                  30          


Asn Ser Ser Lys Gln Leu Leu Lys Ser Asp Val Asn Tyr Gln Cys Leu 
        35                  40                  45              


Phe Ser Ala His Val Leu His Leu Arg Gly Val Leu Thr Thr Gln Pro 
    50                  55                  60                  


Val Glu Asp Glu Arg Gly Asn Val Phe Leu Trp Asn Gly Glu Ile Phe 
65                  70                  75                  80  


Ser Gly Ile Lys Val Glu Ala Glu Glu Asn Asp Thr Gln Ile Leu Phe 
                85                  90                  95      


Asn Tyr Leu Ser Ser Cys Lys Asn Glu Ser Glu Ile Leu Ser Leu Phe 
            100                 105                 110         


Ser Glu Val Gln Gly Pro Trp Ser Phe Ile Tyr Tyr Gln Ala Ser Ser 
        115                 120                 125             


His Tyr Leu Trp Phe Gly Arg Asp Phe Phe Gly Arg Arg Ser Leu Leu 
    130                 135                 140                 


Trp His Phe Ser Asn Leu Gly Lys Ser Phe Cys Leu Ser Ser Val Gly 
145                 150                 155                 160 


Thr Gln Thr Ser Gly Leu Ala Asn Gln Trp Gln Glu Val Pro Ala Ser 
                165                 170                 175     


Gly Leu Phe Arg Ile Asp Leu Lys Ser Thr Val Ile Ser Gly Cys Ile 
            180                 185                 190         


Ile Leu Gln Leu Tyr Pro Trp Lys Tyr Ile Ser Arg Glu Asn Ile Ile 
        195                 200                 205             


Glu Glu Asn Val Asn Ser Leu Ser Gln Ile Ser Ala Asp Leu Pro Ala 
    210                 215                 220                 


Phe Val Ser Val Val Ala Asn Glu Ala Lys Leu Tyr Leu Glu Lys Pro 
225                 230                 235                 240 


Val Val Pro Leu Asn Met Met Leu Pro Gln Ala Ala Leu Glu Thr His 
                245                 250                 255     


Cys Ser Asn Ile Ser Asn Val Pro Pro Thr Arg Glu Ile Leu Gln Val 
            260                 265                 270         


Phe Leu Thr Asp Val His Met Lys Glu Val Ile Gln Gln Phe Ile Asp 
        275                 280                 285             


Val Leu Ser Val Ala Val Lys Lys Arg Val Leu Cys Leu Pro Arg Asp 
    290                 295                 300                 


Glu Asn Leu Thr Ala Asn Glu Val Leu Lys Thr Cys Asp Arg Lys Ala 
305                 310                 315                 320 


Asn Val Ala Ile Leu Phe Ser Gly Gly Ile Asp Ser Met Val Ile Ala 
                325                 330                 335     


Thr Leu Ala Asp Arg His Ile Pro Leu Asp Glu Pro Ile Asp Leu Leu 
            340                 345                 350         


Asn Val Ala Phe Ile Ala Glu Glu Lys Thr Met Pro Thr Thr Phe Asn 
        355                 360                 365             


Arg Glu Gly Asn Lys Gln Lys Asn Lys Cys Glu Ile Pro Ser Glu Glu 
    370                 375                 380                 


Phe Ser Lys Asp Val Ala Ala Ala Ala Ala Asp Ser Pro Asn Lys His 
385                 390                 395                 400 


Val Ser Val Pro Asp Arg Ile Thr Gly Arg Ala Gly Leu Lys Glu Leu 
                405                 410                 415     


Gln Ala Val Ser Pro Ser Arg Ile Trp Asn Phe Val Glu Ile Asn Val 
            420                 425                 430         


Ser Met Glu Glu Leu Gln Lys Leu Arg Arg Thr Arg Ile Cys His Leu 
        435                 440                 445             


Ile Arg Pro Leu Asp Thr Val Leu Asp Asp Ser Ile Gly Cys Ala Val 
    450                 455                 460                 


Trp Phe Ala Ser Arg Gly Ile Gly Trp Leu Val Ala Gln Glu Gly Val 
465                 470                 475                 480 


Lys Ser Tyr Gln Ser Asn Ala Lys Val Val Leu Thr Gly Ile Gly Ala 
                485                 490                 495     


Asp Glu Gln Leu Ala Gly Tyr Ser Arg His Arg Val Arg Phe Gln Ser 
            500                 505                 510         


His Gly Leu Glu Gly Leu Asn Lys Glu Ile Met Met Glu Leu Gly Arg 
        515                 520                 525             


Ile Ser Ser Arg Asn Leu Gly Arg Asp Asp Arg Val Ile Gly Asp His 
    530                 535                 540                 


Gly Lys Glu Ala Arg Phe Pro Phe Leu Asp Glu Asn Val Val Ser Phe 
545                 550                 555                 560 


Leu Asn Ser Leu Pro Ile Trp Glu Lys Ala Asn Leu Thr Leu Pro Arg 
                565                 570                 575     


Gly Ile Gly Glu Lys Leu Leu Leu Arg Leu Ala Ala Val Glu Leu Gly 
            580                 585                 590         


Leu Thr Ala Ser Ala Leu Leu Pro Lys Arg Ala Met Gln Phe Gly Ser 
        595                 600                 605             


Arg Ile Ala Lys Met Glu Lys Ile Asn Glu Lys Ala Ser Asp Lys Cys 
    610                 615                 620                 


Gly Arg Leu Gln Ile Met Ser Leu Glu Asn Leu Ser Ile Glu Lys Glu 
625                 630                 635                 640 


Thr Lys Leu 
            


<210>  11
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Arg Pro Glu Glu Gly Lys Gln Ser Pro Pro Pro Gln Pro Trp 
1               5                   10                  15      


Gly Arg Leu Leu Arg Leu Gly Ala Glu Glu Gly Glu Pro His Val Leu 
            20                  25                  30          


Leu Arg Lys Arg Glu Trp Thr Ile Gly Arg Arg Arg Gly Cys Asp Leu 
        35                  40                  45              


Ser Phe Pro Ser Asn Lys Leu Val Ser Gly Asp His Cys Arg Ile Val 
    50                  55                  60                  


Val Asp Glu Lys Ser Gly Gln Val Thr Leu Glu Asp Thr Ser Thr Ser 
65                  70                  75                  80  


Gly Thr Val Ile Asn Lys Leu Lys Val Val Lys Lys Gln Thr Cys Pro 
                85                  90                  95      


Leu Gln Thr Gly Asp Val Ile Tyr Leu Val Tyr Arg Lys Asn Glu Pro 
            100                 105                 110         


Glu His Asn Val Ala Tyr Leu Tyr Glu Ser Leu Ser Glu Lys Gln Gly 
        115                 120                 125             


Met Thr Gln Glu Ser Phe Glu Ala Asn Lys Glu Asn Val Phe His Gly 
    130                 135                 140                 


Thr Lys Asp Thr Ser Gly Ala Gly Ala Gly Arg Gly Ala Asp Pro Arg 
145                 150                 155                 160 


Val Pro Pro Ser Ser Pro Ala Thr Gln Val Cys Phe Glu Glu Pro Gln 
                165                 170                 175     


Pro Ser Thr Ser Thr Ser Asp Leu Phe Pro Thr Ala Ser Ala Ser Ser 
            180                 185                 190         


Thr Glu Pro Ser Pro Ala Gly Arg Glu Arg Ser Ser Ser Cys Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ile Ser Pro Lys Gly Ser Gly Pro Ser Val Ala Ser 
    210                 215                 220                 


Asp Glu Val Ser Ser Phe Ala Ser Ala Leu Pro Asp Arg Lys Thr Ala 
225                 230                 235                 240 


Ser Phe Ser Ser Leu Glu Pro Gln Asp Gln Glu Asp Leu Glu Pro Val 
                245                 250                 255     


Lys Lys Lys Met Arg Gly Asp Gly Asp Leu Asp Leu Asn Gly Gln Leu 
            260                 265                 270         


Leu Val Ala Gln Pro Arg Arg Asn Ala Gln Thr Val His Glu Asp Val 
        275                 280                 285             


Arg Ala Ala Ala Gly Lys Pro Asp Lys Met Glu Glu Thr Leu Thr Cys 
    290                 295                 300                 


Ile Ile Cys Gln Asp Leu Leu His Asp Cys Val Ser Leu Gln Pro Cys 
305                 310                 315                 320 


Met His Thr Phe Cys Ala Ala Cys Tyr Ser Gly Trp Met Glu Arg Ser 
                325                 330                 335     


Ser Leu Cys Pro Thr Cys Arg Cys Pro Val Glu Arg Ile Cys Lys Asn 
            340                 345                 350         


His Ile Leu Asn Asn Leu Val Glu Ala Tyr Leu Ile Gln His Pro Asp 
        355                 360                 365             


Lys Ser Arg Ser Glu Glu Asp Val Gln Ser Met Asp Ala Arg Asn Lys 
    370                 375                 380                 


Ile Thr Gln Asp Met Leu Gln Pro Lys Val Arg Arg Ser Phe Ser Asp 
385                 390                 395                 400 


Glu Glu Gly Ser Ser Glu Asp Leu Leu Glu Leu Ser Asp Val Asp Ser 
                405                 410                 415     


Glu Ser Ser Asp Ile Ser Gln Pro Tyr Val Val Cys Arg Gln Cys Pro 
            420                 425                 430         


Glu Tyr Arg Arg Gln Ala Ala Gln Pro Pro His Cys Pro Ala Pro Glu 
        435                 440                 445             


Gly Glu Pro Gly Ala Pro Gln Ala Leu Gly Asp Ala Pro Ser Thr Ser 
    450                 455                 460                 


Val Ser Leu Thr Thr Ala Val Gln Asp Tyr Val Cys Pro Leu Gln Gly 
465                 470                 475                 480 


Ser His Ala Leu Cys Thr Cys Cys Phe Gln Pro Met Pro Asp Arg Arg 
                485                 490                 495     


Ala Glu Arg Glu Gln Asp Pro Arg Val Ala Pro Gln Gln Cys Ala Val 
            500                 505                 510         


Cys Leu Gln Pro Phe Cys His Leu Tyr Trp Gly Cys Thr Arg Thr Gly 
        515                 520                 525             


Cys Tyr Gly Cys Leu Ala Pro Phe Cys Glu Leu Asn Leu Gly Asp Lys 
    530                 535                 540                 


Cys Leu Asp Gly Val Leu Asn Asn Asn Ser Tyr Glu Ser Asp Ile Leu 
545                 550                 555                 560 


Lys Asn Tyr Leu Ala Thr Arg Gly Leu Thr Trp Lys Asn Met Leu Thr 
                565                 570                 575     


Glu Ser Leu Val Ala Leu Gln Arg Gly Val Phe Leu Leu Ser Asp Tyr 
            580                 585                 590         


Arg Val Thr Gly Asp Thr Val Leu Cys Tyr Cys Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Arg Glu Leu Thr Tyr Gln Tyr Arg Gln Asn Ile Pro Ala Ser Glu 
    610                 615                 620                 


Leu Pro Val Ala Val Thr Ser Arg Pro Asp Cys Tyr Trp Gly Arg Asn 
625                 630                 635                 640 


Cys Arg Thr Gln Val Lys Ala His His Ala Met Lys Phe Asn His Ile 
                645                 650                 655     


Cys Glu Gln Thr Arg Phe Lys Asn 
            660                 


<210>  12
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Asp Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn 
                325                 330                 335     


Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe 
            340                 345                 350         


Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys 
        355                 360                 365             


Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys 
    370                 375                 380                 


Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala 
385                 390                 395                 400 


Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys 
                405                 410                 415     


Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile 
            420                 425                 430         


Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile 
        435                 440                 445             


Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser 
    450                 455                 460                 


Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys 
465                 470                 475                 480 


Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys Lys Lys Asp Tyr Ala 
                485                 490                 495     


Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys 
            500                 505                 510         


Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile 
        515                 520                 525             


Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys 
    530                 535                 540                 


Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser 
                565                 570                 575     


Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe 
            580                 585                 590         


Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        595                 600                 


<210>  13
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Leu Trp Val Asp Lys Tyr Arg Pro Lys Ser Leu Asn Ala Leu 
1               5                   10                  15      


Ser His Asn Glu Glu Leu Thr Asn Phe Leu Lys Ser Leu Ser Asp Gln 
            20                  25                  30          


Pro Arg Asp Leu Pro His Leu Leu Leu Tyr Gly Pro Asn Gly Thr Gly 
        35                  40                  45              


Lys Lys Thr Arg Cys Met Ala Leu Leu Glu Ser Ile Phe Gly Pro Gly 
    50                  55                  60                  


Val Tyr Arg Leu Lys Ile Asp Val Arg Gln Phe Val Thr Ala Ser Asn 
65                  70                  75                  80  


Arg Lys Leu Glu Leu Asn Val Val Ser Ser Pro Tyr His Leu Glu Ile 
                85                  90                  95      


Thr Pro Ser Asp Met Gly Asn Asn Asp Arg Ile Val Ile Gln Glu Leu 
            100                 105                 110         


Leu Lys Glu Val Ala Gln Met Glu Gln Val Asp Phe Gln Asp Ser Lys 
        115                 120                 125             


Asp Gly Leu Ala His Arg Tyr Lys Cys Val Ile Ile Asn Glu Ala Asn 
    130                 135                 140                 


Ser Leu Thr Lys Asp Ala Gln Ala Ala Leu Arg Arg Thr Met Glu Lys 
145                 150                 155                 160 


Tyr Ser Lys Asn Ile Arg Leu Ile Met Val Cys Asp Ser Met Ser Pro 
                165                 170                 175     


Ile Ile Ala Pro Ile Lys Ser Arg Cys Leu Leu Ile Arg Cys Pro Ala 
            180                 185                 190         


Pro Ser Asp Ser Glu Ile Ser Thr Ile Leu Ser Asp Val Val Thr Asn 
        195                 200                 205             


Glu Arg Ile Gln Leu Glu Thr Lys Asp Ile Leu Lys Arg Ile Ala Gln 
    210                 215                 220                 


Ala Ser Asn Gly Asn Leu Arg Val Ser Leu Leu Met Leu Glu Ser Met 
225                 230                 235                 240 


Ala Leu Asn Asn Glu Leu Ala Leu Lys Ser Ser Ser Pro Ile Ile Lys 
                245                 250                 255     


Pro Asp Trp Ile Ile Val Ile His Lys Leu Thr Arg Lys Ile Val Lys 
            260                 265                 270         


Glu Arg Ser Val Asn Ser Leu Ile Glu Cys Arg Ala Val Leu Tyr Asp 
        275                 280                 285             


Leu Leu Ala His Cys Ile Pro Ala Asn Ile Ile Leu Lys Glu Leu Thr 
    290                 295                 300                 


Phe Ser Leu Leu Asp Val Glu Thr Leu Asn Thr Thr Asn Lys Ser Ser 
305                 310                 315                 320 


Ile Ile Glu Tyr Ser Ser Val Phe Asp Glu Arg Leu Ser Leu Gly Asn 
                325                 330                 335     


Lys Ala Ile Phe His Leu Glu Gly Phe Ile Ala Lys Val Met Cys Cys 
            340                 345                 350         


Leu Asp 
        


<210>  14
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Lys Leu Gly Val Glu Pro Glu Glu Glu Gly Gly Gly Asp Asp 
1               5                   10                  15      


Asp Glu Glu Asp Ala Glu Ala Trp Ala Met Glu Leu Ala Asp Val Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Gln Gly Val His Asp Gln Val Leu Pro Thr Pro 
        35                  40                  45              


Asn Ala Ser Ser Arg Val Ile Val His Val Asp Leu Asp Cys Phe Tyr 
    50                  55                  60                  


Ala Gln Val Glu Met Ile Ser Asn Pro Glu Leu Lys Asp Lys Pro Leu 
65                  70                  75                  80  


Gly Val Gln Gln Lys Tyr Leu Val Val Thr Cys Asn Tyr Glu Ala Arg 
                85                  90                  95      


Lys Leu Gly Val Lys Lys Leu Met Asn Val Arg Asp Ala Lys Glu Lys 
            100                 105                 110         


Cys Pro Gln Leu Val Leu Val Asn Gly Glu Asp Leu Thr Arg Tyr Arg 
        115                 120                 125             


Glu Met Ser Tyr Lys Val Thr Glu Leu Leu Glu Glu Phe Ser Pro Val 
    130                 135                 140                 


Val Glu Arg Leu Gly Phe Asp Glu Asn Phe Val Asp Leu Thr Glu Met 
145                 150                 155                 160 


Val Glu Lys Arg Leu Gln Gln Leu Gln Ser Asp Glu Leu Ser Ala Val 
                165                 170                 175     


Thr Val Ser Gly His Val Tyr Asn Asn Gln Ser Ile Asn Leu Leu Asp 
            180                 185                 190         


Val Leu His Ile Arg Leu Leu Val Gly Ser Gln Ile Ala Ala Glu Met 
        195                 200                 205             


Arg Glu Ala Met Tyr Asn Gln Leu Gly Leu Thr Gly Cys Ala Gly Val 
    210                 215                 220                 


Ala Ser Asn Lys Leu Leu Ala Lys Leu Val Ser Gly Val Phe Lys Pro 
225                 230                 235                 240 


Asn Gln Gln Thr Val Leu Leu Pro Glu Ser Cys Gln His Leu Ile His 
                245                 250                 255     


Ser Leu Asn His Ile Lys Glu Ile Pro Gly Ile Gly Tyr Lys Thr Ala 
            260                 265                 270         


Lys Cys Leu Glu Ala Leu Gly Ile Asn Ser Val Arg Asp Leu Gln Thr 
        275                 280                 285             


Phe Ser Pro Lys Ile Leu Glu Lys Glu Leu Gly Ile Ser Val Ala Gln 
    290                 295                 300                 


Arg Ile Gln Lys Leu Ser Phe Gly Glu Asp Asn Ser Pro Val Ile Leu 
305                 310                 315                 320 


Ser Gly Pro Pro Gln Ser Phe Ser Glu Glu Asp Ser Phe Lys Lys Cys 
                325                 330                 335     


Ser Ser Glu Val Glu Ala Lys Asn Lys Ile Glu Glu Leu Leu Ala Ser 
            340                 345                 350         


Leu Leu Asn Arg Val Cys Gln Asp Gly Arg Lys Pro His Thr Val Arg 
        355                 360                 365             


Leu Ile Ile Arg Arg Tyr Ser Ser Glu Lys His Tyr Gly Arg Glu Ser 
    370                 375                 380                 


Arg Gln Cys Pro Ile Pro Ser His Val Ile Gln Lys Leu Gly Thr Gly 
385                 390                 395                 400 


Asn Tyr Asp Val Met Thr Pro Met Val Asp Ile Leu Met Lys Leu Phe 
                405                 410                 415     


Arg Asn Met Val Asn Val Lys Met Pro Phe His Leu Thr Leu Leu Ser 
            420                 425                 430         


Val Cys Phe Cys Asn Leu Lys Ala Leu Asn Thr Ala Lys Lys Gly Leu 
        435                 440                 445             


Ile Asp Tyr Tyr Leu Met Pro Ser Leu Ser Thr Thr Ser Arg Ser Gly 
    450                 455                 460                 


Lys His Ser Phe Lys Met Lys Asp Thr His Met Glu Asp Phe Pro Lys 
465                 470                 475                 480 


Asp Lys Glu Thr Asn Arg Asp Phe Leu Pro Ser Gly Arg Ile Glu Ser 
                485                 490                 495     


Thr Arg Thr Arg Glu Ser Pro Leu Asp Thr Thr Asn Phe Ser Lys Glu 
            500                 505                 510         


Lys Asp Ile Asn Glu Phe Pro Leu Cys Ser Leu Pro Glu Gly Val Asp 
        515                 520                 525             


Gln Glu Val Phe Lys Gln Leu Pro Val Asp Ile Gln Glu Glu Ile Leu 
    530                 535                 540                 


Ser Gly Lys Ser Arg Glu Lys Phe Gln Gly Lys Gly Ser Val Ser Cys 
545                 550                 555                 560 


Pro Leu His Ala Ser Arg Gly Val Leu Ser Phe Phe Ser Lys Lys Gln 
                565                 570                 575     


Met Gln Asp Ile Pro Ile Asn Pro Arg Asp His Leu Ser Ser Ser Lys 
            580                 585                 590         


Gln Val Ser Ser Val Ser Pro Cys Glu Pro Gly Thr Ser Gly Phe Asn 
        595                 600                 605             


Ser Ser Ser Ser Ser Tyr Met Ser Ser Gln Lys Asp Tyr Ser Tyr Tyr 
    610                 615                 620                 


Leu Asp Asn Arg Leu Lys Asp Glu Arg Ile Ser Gln Gly Pro Lys Glu 
625                 630                 635                 640 


Pro Gln Gly Phe His Phe Thr Asn Ser Asn Pro Ala Val Ser Ala Phe 
                645                 650                 655     


His Ser Phe Pro Asn Leu Gln Ser Glu Gln Leu Phe Ser Arg Asn His 
            660                 665                 670         


Thr Thr Asp Ser His Lys Gln Thr Val Ala Thr Asp Ser His Glu Gly 
        675                 680                 685             


Leu Thr Glu Asn Arg Glu Pro Asp Ser Val Asp Glu Lys Ile Thr Phe 
    690                 695                 700                 


Pro Ser Asp Ile Asp Pro Gln Val Phe Tyr Glu Leu Pro Glu Ala Val 
705                 710                 715                 720 


Gln Lys Glu Leu Leu Ala Glu Trp Lys Arg Ala Gly Ser Asp Phe His 
                725                 730                 735     


Ile Gly His Lys 
            740 


<210>  15
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
65                  70                  75                  80  


Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
                85                  90                  95      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 
            100                 105                 110         


Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 
        115                 120                 125             


Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn 
    130                 135                 140                 


Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly 
145                 150                 155                 160 


Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln 
                165                 170                 175     


Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val 
            180                 185                 190         


Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro 
        195                 200                 205             


Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg 
    210                 215                 220                 


Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His 
225                 230                 235                 240 


Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala 
                245                 250                 255     


Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu 
            260                 265                 270         


Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg 
        275                 280                 285             


Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp 
    290                 295                 300                 


Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly 
305                 310                 315                 320 


Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln 
                325                 330                 335     


Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg 
            340                 345                 350         


Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly 
        355                 360                 365             


Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala 
    370                 375                 380                 


Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly 
385                 390                 395                 400 


Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro 
                405                 410                 415     


Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser 
            420                 425                 430         


Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys 
        435                 440                 445             


Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln 
    450                 455                 460                 


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser 
465                 470                 475                 480 


Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp 
                485                 490                 495     


Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys 
            500                 505                 510         


Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu 
        515                 520                 525             


Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp 
    530                 535                 540                 


Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile 
545                 550                 555                 560 


Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala 
                565                 570                 575     


Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr 
            580                 585                 590         


Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser 
        595                 600                 605             


Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
    610                 615                 620                 


Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val 
625                 630                 635                 640 


Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 
                645                 650                 655     


Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 
            660                 665                 670         


Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His 
        675                 680                 685             


Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu 
    690                 695                 700                 


Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly 
705                 710                 715                 720 


Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn 
                725                 730                 735     


Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His 
            740                 745                 750         


Gln Leu Arg Gln Ala 
        755         


<210>  16
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Ser Ser Tyr Trp Ser Glu Thr Ser Ser Ser Ser Cys Gly Thr 
1               5                   10                  15      


Gln Gln Leu Pro Glu Val Leu Gln Cys Gln Pro Gln His Tyr His Cys 
            20                  25                  30          


Tyr His Gln Ser Ser Gln Ala Gln Gln Pro Pro Glu Lys Asn Val Val 
        35                  40                  45              


Tyr Glu Arg Val Arg Thr Tyr Ser Gly Pro Met Asn Lys Val Val Gln 
    50                  55                  60                  


Ala Leu Asp Pro Phe Asn Ser Arg Glu Val Leu Ser Pro Leu Lys Thr 
65                  70                  75                  80  


Thr Ser Ser Tyr Gln Asn Leu Val Trp Ser Asp His Ser Gln Glu Leu 
                85                  90                  95      


His Ser Pro Thr Leu Lys Ile Ser Thr Cys Ala Pro Ser Thr Leu His 
            100                 105                 110         


Ile Thr Gln Asn Thr Glu Gln Glu Leu His Ser Pro Thr Val Lys Leu 
        115                 120                 125             


Thr Thr Tyr Pro Gln Thr Thr Ile Arg Lys Tyr Val Val Gln Asn Pro 
    130                 135                 140                 


Glu Gln Glu Pro Leu Ser Gln Phe Leu Arg Gly Ser His Phe Phe Pro 
145                 150                 155                 160 


Gly Asn Asn Val Ile Tyr Glu Lys Thr Ile Arg Lys Val Glu Lys Leu 
                165                 170                 175     


Asn Thr Asp Gln Gly Cys His Pro Gln Ala Gln Cys His His His Ile 
            180                 185                 190         


Ile Gln Gln Pro Gln Val Ile His Ser Ala His Trp Gln Gln Pro Asp 
        195                 200                 205             


Ser Ser Gln Gln Ile Gln Ala Ile Thr Gly Asn Asn Pro Ile Ser Thr 
    210                 215                 220                 


His Ile Gly Asn Glu Leu Cys His Ser Gly Ser Ser Gln Ile Cys Glu 
225                 230                 235                 240 


Gln Val Ile Ile Gln Asp Asp Gly Pro Glu Lys Leu Asp Pro Arg Tyr 
                245                 250                 255     


Phe Gly Glu Leu Leu Ala Asp Leu Ser Arg Lys Asn Thr Asp Leu Tyr 
            260                 265                 270         


His Cys Leu Leu Glu His Leu Gln Arg Ile Gly Gly Ser Lys Gln Asp 
        275                 280                 285             


Phe Glu Ser Thr Asp Glu Ser Glu Asp Ile Glu Ser Leu Ile Pro Lys 
    290                 295                 300                 


Gly Leu Ser Glu Phe Thr Lys Gln Gln Ile Arg Tyr Ile Leu Gln Met 
305                 310                 315                 320 


Arg Gly Met Ser Asp Lys Ser Leu Arg Leu Val Leu Ser Thr Phe Ser 
                325                 330                 335     


Asn Ile Arg Glu Glu Leu Gly His Leu Gln Asn Asp Met Thr Ser Leu 
            340                 345                 350         


Glu Asn Asp Lys Met Arg Leu Glu Lys Asp Leu Ser Phe Lys Asp Thr 
        355                 360                 365             


Gln Leu Lys Glu Tyr Glu Glu Leu Leu Ala Ser Val Arg Ala Asn Asn 
    370                 375                 380                 


His Gln Gln Gln Gln Gly Leu Gln Asp Ser Ser Ser Lys Cys Gln Ala 
385                 390                 395                 400 


Leu Glu Glu Asn Asn Leu Ser Leu Arg His Thr Leu Ser Asp Met Glu 
                405                 410                 415     


Tyr Arg Leu Lys Glu Leu Glu Tyr Cys Lys Arg Asn Leu Glu Gln Glu 
            420                 425                 430         


Asn Gln Asn Leu Arg Met Gln Val Ser Glu Thr Cys Thr Gly Pro Met 
        435                 440                 445             


Leu Gln Ala Lys Met Asp Glu Ile Gly Asn His Tyr Thr Glu Met Val 
    450                 455                 460                 


Lys Asn Leu Arg Met Glu Lys Asp Arg Glu Ile Cys Arg Leu Arg Ser 
465                 470                 475                 480 


Gln Leu Asn Gln Tyr His Lys Asp Val Ser Lys Arg Glu Gly Ser Cys 
                485                 490                 495     


Ser Asp Phe Gln Phe Lys Leu His Glu Leu Thr Ser Leu Leu Glu Glu 
            500                 505                 510         


Lys Asp Ser Leu Ile Lys Arg Gln Ser Glu Glu Leu Ser Lys Leu Arg 
        515                 520                 525             


Gln Glu Ile Tyr Ser Ser His Asn Gln Pro Ser Thr Gly Gly Arg Thr 
    530                 535                 540                 


Thr Ile Thr Thr Lys Lys Tyr Arg Thr Gln Tyr Pro Ile Leu Gly Leu 
545                 550                 555                 560 


Leu Tyr Asp Asp Tyr Glu Tyr Ile Pro Pro Gly Ser Glu Thr Gln Thr 
                565                 570                 575     


Ile Val Ile Glu Lys Thr Glu Asp Lys Tyr Thr Cys Pro 
            580                 585                 


<210>  17
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
1               5                   10                  15      


Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                85                  90                  95      


Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
            100                 105                 110         


Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
        115                 120                 125             


Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
    130                 135                 140                 


<210>  18
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Thr Ala Leu Val Tyr His Glu Asp Met Thr Ala Thr Arg Leu 
1               5                   10                  15      


Leu Trp Asp Asp Pro Glu Cys Glu Ile Glu Arg Pro Glu Arg Leu Thr 
            20                  25                  30          


Ala Ala Leu Asp Arg Leu Arg Gln Arg Gly Leu Glu Gln Arg Cys Leu 
        35                  40                  45              


Arg Leu Ser Ala Arg Glu Ala Ser Glu Glu Glu Leu Gly Leu Val His 
    50                  55                  60                  


Ser Pro Glu Tyr Val Ser Leu Val Arg Glu Thr Gln Val Leu Gly Lys 
65                  70                  75                  80  


Glu Glu Leu Gln Ala Leu Ser Gly Gln Phe Asp Ala Ile Tyr Phe His 
                85                  90                  95      


Pro Ser Thr Phe His Cys Ala Arg Leu Ala Ala Gly Ala Gly Leu Gln 
            100                 105                 110         


Leu Val Asp Ala Val Leu Thr Gly Ala Val Gln Asn Gly Leu Ala Leu 
        115                 120                 125             


Val Arg Pro Pro Gly His His Gly Gln Arg Ala Ala Ala Asn Gly Phe 
    130                 135                 140                 


Cys Val Phe Asn Asn Val Ala Ile Ala Ala Ala His Ala Lys Gln Lys 
145                 150                 155                 160 


His Gly Leu His Arg Ile Leu Val Val Asp Trp Asp Val His His Gly 
                165                 170                 175     


Gln Gly Ile Gln Tyr Leu Phe Glu Asp Asp Pro Ser Val Leu Tyr Phe 
            180                 185                 190         


Ser Trp His Arg Tyr Glu His Gly Arg Phe Trp Pro Phe Leu Arg Glu 
        195                 200                 205             


Ser Asp Ala Asp Ala Val Gly Arg Gly Gln Gly Leu Gly Phe Thr Val 
    210                 215                 220                 


Asn Leu Pro Trp Asn Gln Val Gly Met Gly Asn Ala Asp Tyr Val Ala 
225                 230                 235                 240 


Ala Phe Leu His Leu Leu Leu Pro Leu Ala Phe Glu Phe Asp Pro Glu 
                245                 250                 255     


Leu Val Leu Val Ser Ala Gly Phe Asp Ser Ala Ile Gly Asp Pro Glu 
            260                 265                 270         


Gly Gln Met Gln Ala Thr Pro Glu Cys Phe Ala His Leu Thr Gln Leu 
        275                 280                 285             


Leu Gln Val Leu Ala Gly Gly Arg Val Cys Ala Val Leu Glu Gly Gly 
    290                 295                 300                 


Tyr His Leu Glu Ser Leu Ala Glu Ser Val Cys Met Thr Val Gln Thr 
305                 310                 315                 320 


Leu Leu Gly Asp Pro Ala Pro Pro Leu Ser Gly Pro Met Ala Pro Cys 
                325                 330                 335     


Gln Ser Ala Leu Glu Ser Ile Gln Ser Ala Arg Ala Ala Gln Ala Pro 
            340                 345                 350         


His Trp Lys Ser Leu Gln Gln Gln Asp Val Thr Ala Val Pro Met Ser 
        355                 360                 365             


Pro Ser Ser His Ser Pro Glu Gly Arg Pro Pro Pro Leu Leu Pro Gly 
    370                 375                 380                 


Gly Pro Val Cys Lys Ala Ala Ala Ser Ala Pro Ser Ser Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Cys Leu Cys Pro Ala Pro Ser Val Arg Thr Ala Val Ala Leu 
                405                 410                 415     


Thr Thr Pro Asp Ile Thr Leu Val Leu Pro Pro Asp Val Ile Gln Gln 
            420                 425                 430         


Glu Ala Ser Ala Leu Arg Glu Glu Thr Glu Ala Trp Ala Arg Pro His 
        435                 440                 445             


Glu Ser Leu Ala Arg Glu Glu Ala Leu Thr Ala Leu Gly Lys Leu Leu 
    450                 455                 460                 


Tyr Leu Leu Asp Gly Met Leu Asp Gly Gln Val Asn Ser Gly Ile Ala 
465                 470                 475                 480 


Ala Thr Pro Ala Ser Ala Ala Ala Ala Thr Leu Asp Val Ala Val Arg 
                485                 490                 495     


Arg Gly Leu Ser His Gly Ala Gln Arg Leu Leu Cys Val Ala Leu Gly 
            500                 505                 510         


Gln Leu Asp Arg Pro Pro Asp Leu Ala His Asp Gly Arg Ser Leu Trp 
        515                 520                 525             


Leu Asn Ile Arg Gly Lys Glu Ala Ala Ala Leu Ser Met Phe His Val 
    530                 535                 540                 


Ser Thr Pro Leu Pro Val Met Thr Gly Gly Phe Leu Ser Cys Ile Leu 
545                 550                 555                 560 


Gly Leu Val Leu Pro Leu Ala Tyr Gly Phe Gln Pro Asp Leu Val Leu 
                565                 570                 575     


Val Ala Leu Gly Pro Gly His Gly Leu Gln Gly Pro His Ala Ala Leu 
            580                 585                 590         


Leu Ala Ala Met Leu Arg Gly Leu Ala Gly Gly Arg Val Leu Ala Leu 
        595                 600                 605             


Leu Glu Glu Asn Ser Thr Pro Gln Leu Ala Gly Ile Leu Ala Arg Val 
    610                 615                 620                 


Leu Asn Gly Glu Ala Pro Pro Ser Leu Gly Pro Ser Ser Val Ala Ser 
625                 630                 635                 640 


Pro Glu Asp Val Gln Ala Leu Met Tyr Leu Arg Gly Gln Leu Glu Pro 
                645                 650                 655     


Gln Trp Lys Met Leu Gln Cys His Pro His Leu Val Ala 
            660                 665                 


<210>  19
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Arg Ala Val Gly Pro Glu Arg Arg Leu Leu Ala Val Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Ile Gly Met Arg Ser Glu Leu Gly Val Leu Val Pro Gly 
            20                  25                  30          


Thr Gly Leu Ala Ala Ile Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu His Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser Arg Asn Gln Arg Ile Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Phe Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Val Cys Leu 
                85                  90                  95      


Ala Gln Thr Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Thr Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Ala Leu Trp Ser Asp Gly Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Met Ala Gly Gln Tyr Val Ile Pro Glu Val Cys Leu Phe Phe 
                165                 170                 175     


Gln Asn Gln Leu Phe Arg Gly Asn Arg Ala Thr Lys Val Asp Ala Arg 
            180                 185                 190         


Arg Phe Ala Ala Phe Cys Ser Pro Asn Leu Leu Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Ile Thr Ile Asn Arg Glu Leu Val Arg Lys Val Asp Gly 
    210                 215                 220                 


Lys Ala Gly Leu Val Val His Ser Ser Met Glu Gln Asp Val Gly Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Met Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Thr Lys Pro Asp Leu Leu Gln Glu Leu Arg Val Ala Thr Glu 
        275                 280                 285             


Arg Gly Leu Val Ile Val Asn Cys Thr His Cys Leu Gln Gly Ala Val 
    290                 295                 300                 


Thr Thr Asp Tyr Ala Ala Gly Met Ala Met Ala Gly Ala Gly Val Ile 
305                 310                 315                 320 


Ser Gly Phe Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr 
                325                 330                 335     


Val Leu Gly Gln Pro Gly Leu Ser Leu Asp Val Arg Lys Glu Leu Leu 
            340                 345                 350         


Thr Lys Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg 
        355                 360                 365             


Arg Pro Ser Leu Gln Gly Asn Thr Leu Gly Gly Gly Val Ser Trp Leu 
    370                 375                 380                 


Leu Ser Leu Ser Gly Ser Gln Glu Ala Asp Ala Leu Arg Asn Ala Leu 
385                 390                 395                 400 


Val Pro Ser Leu Ala Cys Ala Ala Ala His Ala Gly Asp Val Glu Ala 
                405                 410                 415     


Leu Gln Ala Leu Val Glu Leu Gly Ser Asp Leu Gly Leu Val Asp Phe 
            420                 425                 430         


Asn Gly Gln Thr Pro Leu His Ala Ala Ala Arg Gly Gly His Thr Glu 
        435                 440                 445             


Ala Val Thr Met Leu Leu Gln Arg Gly Val Asp Val Asn Thr Arg Asp 
    450                 455                 460                 


Thr Asp Gly Phe Ser Pro Leu Leu Leu Ala Val Arg Gly Arg His Pro 
465                 470                 475                 480 


Gly Val Ile Gly Leu Leu Arg Glu Ala Gly Ala Ser Leu Ser Thr Gln 
                485                 490                 495     


Glu Leu Glu Glu Ala Gly Thr Glu Leu Cys Arg Leu Ala Tyr Arg Ala 
            500                 505                 510         


Asp Leu Glu Gly Leu Gln Val Trp Trp Gln Ala Gly Ala Asp Leu Gly 
        515                 520                 525             


Gln Pro Gly Tyr Asp Gly His Ser Ala Leu His Val Ala Glu Ala Ala 
    530                 535                 540                 


Gly Asn Leu Ala Val Val Ala Phe Leu Gln Ser Leu Glu Gly Ala Val 
545                 550                 555                 560 


Gly Ala Gln Ala Pro Cys Pro Glu Val Leu Pro Gly Val 
                565                 570             


<210>  20
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gln Trp Thr Ser Leu Leu Leu Leu Ala Gly Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gln Ala Gln Tyr Glu Asp Asp Pro His Trp Trp Phe His Tyr Leu Arg 
            20                  25                  30          


Ser Gln Gln Ser Thr Tyr Tyr Asp Pro Tyr Asp Pro Tyr Pro Tyr Glu 
        35                  40                  45              


Thr Tyr Glu Pro Tyr Pro Tyr Gly Val Asp Glu Gly Pro Ala Tyr Thr 
    50                  55                  60                  


Tyr Gly Ser Pro Ser Pro Pro Asp Pro Arg Asp Cys Pro Gln Glu Cys 
65                  70                  75                  80  


Asp Cys Pro Pro Asn Phe Pro Thr Ala Met Tyr Cys Asp Asn Arg Asn 
                85                  90                  95      


Leu Lys Tyr Leu Pro Phe Val Pro Ser Arg Met Lys Tyr Val Tyr Phe 
            100                 105                 110         


Gln Asn Asn Gln Ile Thr Ser Ile Gln Glu Gly Val Phe Asp Asn Ala 
        115                 120                 125             


Thr Gly Leu Leu Trp Ile Ala Leu His Gly Asn Gln Ile Thr Ser Asp 
    130                 135                 140                 


Lys Val Gly Arg Lys Val Phe Ser Lys Leu Arg His Leu Glu Arg Leu 
145                 150                 155                 160 


Tyr Leu Asp His Asn Asn Leu Thr Arg Met Pro Gly Pro Leu Pro Arg 
                165                 170                 175     


Ser Leu Arg Glu Leu His Leu Asp His Asn Gln Ile Ser Arg Val Pro 
            180                 185                 190         


Asn Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu Tyr Leu Gln 
        195                 200                 205             


His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Arg Gly Leu Arg Ser 
    210                 215                 220                 


Leu Ile Leu Leu Asp Leu Ser Tyr Asn His Leu Arg Lys Val Pro Asp 
225                 230                 235                 240 


Gly Leu Pro Ser Ala Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val 
                245                 250                 255     


Tyr Thr Val Pro Asp Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr 
            260                 265                 270         


Val Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn 
        275                 280                 285             


Thr Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln 
    290                 295                 300                 


Leu Gln Lys Ile Pro Pro Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu 
305                 310                 315                 320 


Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe Cys Thr Val 
                325                 330                 335     


Val Asp Val Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp Gly 
            340                 345                 350         


Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys Leu 
        355                 360                 365             


Arg Leu Ala Ser Leu Ile Glu Ile 
    370                 375     


<210>  21
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Arg Leu Ser Trp Gly Tyr Arg Glu His Asn Gly Pro Ile His 
1               5                   10                  15      


Trp Lys Glu Phe Phe Pro Ile Ala Asp Gly Asp Gln Gln Ser Pro Ile 
            20                  25                  30          


Glu Ile Lys Thr Lys Glu Val Lys Tyr Asp Ser Ser Leu Arg Pro Leu 
        35                  40                  45              


Ser Ile Lys Tyr Asp Pro Ser Ser Ala Lys Ile Ile Ser Asn Ser Gly 
    50                  55                  60                  


His Ser Phe Asn Val Asp Phe Asp Asp Thr Glu Asn Lys Ser Val Leu 
65                  70                  75                  80  


Arg Gly Gly Pro Leu Thr Gly Ser Tyr Arg Leu Arg Gln Val His Leu 
                85                  90                  95      


His Trp Gly Ser Ala Asp Asp His Gly Ser Glu His Ile Val Asp Gly 
            100                 105                 110         


Val Ser Tyr Ala Ala Glu Leu His Val Val His Trp Asn Ser Asp Lys 
        115                 120                 125             


Tyr Pro Ser Phe Val Glu Ala Ala His Glu Pro Asp Gly Leu Ala Val 
    130                 135                 140                 


Leu Gly Val Phe Leu Gln Ile Gly Glu Pro Asn Ser Gln Leu Gln Lys 
145                 150                 155                 160 


Ile Thr Asp Thr Leu Asp Ser Ile Lys Glu Lys Gly Lys Gln Thr Arg 
                165                 170                 175     


Phe Thr Asn Phe Asp Leu Leu Ser Leu Leu Pro Pro Ser Trp Asp Tyr 
            180                 185                 190         


Trp Thr Tyr Pro Gly Ser Leu Thr Val Pro Pro Leu Leu Glu Ser Val 
        195                 200                 205             


Thr Trp Ile Val Leu Lys Gln Pro Ile Asn Ile Ser Ser Gln Gln Leu 
    210                 215                 220                 


Ala Lys Phe Arg Ser Leu Leu Cys Thr Ala Glu Gly Glu Ala Ala Ala 
225                 230                 235                 240 


Phe Leu Val Ser Asn His Arg Pro Pro Gln Pro Leu Lys Gly Arg Lys 
                245                 250                 255     


Val Arg Ala Ser Phe His 
            260         


<210>  22
<211>  1150
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Val Pro Ala Arg Thr Cys Gly Ala Ser Arg Pro Gly Pro Ala 
1               5                   10                  15      


Arg Thr Ala Arg Pro Trp Pro Gly Cys Gly Pro His Pro Gly Pro Gly 
            20                  25                  30          


Thr Arg Arg Pro Thr Ser Gly Pro Pro Arg Pro Leu Trp Leu Leu Leu 
        35                  40                  45              


Pro Leu Leu Pro Leu Leu Ala Ala Pro Gly Ala Ser Ala Tyr Ser Phe 
    50                  55                  60                  


Pro Gln Gln His Thr Met Gln His Trp Ala Arg Arg Leu Glu Gln Glu 
65                  70                  75                  80  


Val Asp Gly Val Met Arg Ile Phe Gly Gly Val Gln Gln Leu Arg Glu 
                85                  90                  95      


Ile Tyr Lys Asp Asn Arg Asn Leu Phe Glu Val Gln Glu Asn Glu Pro 
            100                 105                 110         


Gln Lys Leu Val Glu Lys Val Ala Gly Asp Ile Glu Ser Leu Leu Asp 
        115                 120                 125             


Arg Lys Val Gln Ala Leu Lys Arg Leu Ala Asp Ala Ala Glu Asn Phe 
    130                 135                 140                 


Gln Lys Ala His Arg Trp Gln Asp Asn Ile Lys Glu Glu Asp Ile Val 
145                 150                 155                 160 


Tyr Tyr Asp Ala Lys Ala Asp Ala Glu Leu Asp Asp Pro Glu Ser Glu 
                165                 170                 175     


Asp Val Glu Arg Gly Ser Lys Ala Ser Thr Leu Arg Leu Asp Phe Ile 
            180                 185                 190         


Glu Asp Pro Asn Phe Lys Asn Lys Val Asn Tyr Ser Tyr Ala Ala Val 
        195                 200                 205             


Gln Ile Pro Thr Asp Ile Tyr Lys Gly Ser Thr Val Ile Leu Asn Glu 
    210                 215                 220                 


Leu Asn Trp Thr Glu Ala Leu Glu Asn Val Phe Met Glu Asn Arg Arg 
225                 230                 235                 240 


Gln Asp Pro Thr Leu Leu Trp Gln Val Phe Gly Ser Ala Thr Gly Val 
                245                 250                 255     


Thr Arg Tyr Tyr Pro Ala Thr Pro Trp Arg Ala Pro Lys Lys Ile Asp 
            260                 265                 270         


Leu Tyr Asp Val Arg Arg Arg Pro Trp Tyr Ile Gln Gly Ala Ser Ser 
        275                 280                 285             


Pro Lys Asp Met Val Ile Ile Val Asp Val Ser Gly Ser Val Ser Gly 
    290                 295                 300                 


Leu Thr Leu Lys Leu Met Lys Thr Ser Val Cys Glu Met Leu Asp Thr 
305                 310                 315                 320 


Leu Ser Asp Asp Asp Tyr Val Asn Val Ala Ser Phe Asn Glu Lys Ala 
                325                 330                 335     


Gln Pro Val Ser Cys Phe Thr His Leu Val Gln Ala Asn Val Arg Asn 
            340                 345                 350         


Lys Lys Val Phe Lys Glu Ala Val Gln Gly Met Val Ala Lys Gly Thr 
        355                 360                 365             


Thr Gly Tyr Lys Ala Gly Phe Glu Tyr Ala Phe Asp Gln Leu Gln Asn 
    370                 375                 380                 


Ser Asn Ile Thr Arg Ala Asn Cys Asn Lys Met Ile Met Met Phe Thr 
385                 390                 395                 400 


Asp Gly Gly Glu Asp Arg Val Gln Asp Val Phe Glu Lys Tyr Asn Trp 
                405                 410                 415     


Pro Asn Arg Thr Val Arg Val Phe Thr Phe Ser Val Gly Gln His Asn 
            420                 425                 430         


Tyr Asp Val Thr Pro Leu Gln Trp Met Ala Cys Ala Asn Lys Gly Tyr 
        435                 440                 445             


Tyr Phe Glu Ile Pro Ser Ile Gly Ala Ile Arg Ile Asn Thr Gln Glu 
    450                 455                 460                 


Tyr Leu Asp Val Leu Gly Arg Pro Met Val Leu Ala Gly Lys Glu Ala 
465                 470                 475                 480 


Lys Gln Val Gln Trp Thr Asn Val Tyr Glu Asp Ala Leu Gly Leu Gly 
                485                 490                 495     


Leu Val Val Thr Gly Thr Leu Pro Val Phe Asn Leu Thr Gln Asp Gly 
            500                 505                 510         


Pro Gly Glu Lys Lys Asn Gln Leu Ile Leu Gly Val Met Gly Ile Asp 
        515                 520                 525             


Val Ala Leu Asn Asp Ile Lys Arg Leu Thr Pro Asn Tyr Thr Leu Gly 
    530                 535                 540                 


Ala Asn Gly Tyr Val Phe Ala Ile Asp Leu Asn Gly Tyr Val Leu Leu 
545                 550                 555                 560 


His Pro Asn Leu Lys Pro Gln Thr Thr Asn Phe Arg Glu Pro Val Thr 
                565                 570                 575     


Leu Asp Phe Leu Asp Ala Glu Leu Glu Asp Glu Asn Lys Glu Glu Ile 
            580                 585                 590         


Arg Arg Ser Met Ile Asp Gly Asn Lys Gly His Lys Gln Ile Arg Thr 
        595                 600                 605             


Leu Val Lys Ser Leu Asp Glu Arg Tyr Ile Asp Glu Val Thr Arg Asn 
    610                 615                 620                 


Tyr Thr Trp Val Pro Ile Arg Ser Thr Asn Tyr Ser Leu Gly Leu Val 
625                 630                 635                 640 


Leu Pro Pro Tyr Ser Thr Phe Tyr Leu Gln Ala Asn Leu Ser Asp Gln 
                645                 650                 655     


Ile Leu Gln Val Lys Leu Pro Ile Ser Lys Leu Lys Asp Phe Glu Phe 
            660                 665                 670         


Leu Leu Pro Ser Ser Phe Glu Ser Glu Gly His Val Phe Ile Ala Pro 
        675                 680                 685             


Arg Glu Tyr Cys Lys Asp Leu Asn Ala Ser Asp Asn Asn Thr Glu Phe 
    690                 695                 700                 


Leu Lys Asn Phe Ile Glu Leu Met Glu Lys Val Thr Pro Asp Ser Lys 
705                 710                 715                 720 


Gln Cys Asn Asn Phe Leu Leu His Asn Leu Ile Leu Asp Thr Gly Ile 
                725                 730                 735     


Thr Gln Gln Leu Val Glu Arg Val Trp Arg Asp Gln Asp Leu Asn Thr 
            740                 745                 750         


Tyr Ser Leu Leu Ala Val Phe Ala Ala Thr Asp Gly Gly Ile Thr Arg 
        755                 760                 765             


Val Phe Pro Asn Lys Ala Ala Glu Asp Trp Thr Glu Asn Pro Glu Pro 
    770                 775                 780                 


Phe Asn Ala Ser Phe Tyr Arg Arg Ser Leu Asp Asn His Gly Tyr Val 
785                 790                 795                 800 


Phe Lys Pro Pro His Gln Asp Ala Leu Leu Arg Pro Leu Glu Leu Glu 
                805                 810                 815     


Asn Asp Thr Val Gly Ile Leu Val Ser Thr Ala Val Glu Leu Ser Leu 
            820                 825                 830         


Gly Arg Arg Thr Leu Arg Pro Ala Val Val Gly Val Lys Leu Asp Leu 
        835                 840                 845             


Glu Ala Trp Ala Glu Lys Phe Lys Val Leu Ala Ser Asn Arg Thr His 
    850                 855                 860                 


Gln Asp Gln Pro Gln Lys Cys Gly Pro Asn Ser His Cys Glu Met Asp 
865                 870                 875                 880 


Cys Glu Val Asn Asn Glu Asp Leu Leu Cys Val Leu Ile Asp Asp Gly 
                885                 890                 895     


Gly Phe Leu Val Leu Ser Asn Gln Asn His Gln Trp Asp Gln Val Gly 
            900                 905                 910         


Arg Phe Phe Ser Glu Val Asp Ala Asn Leu Met Leu Ala Leu Tyr Asn 
        915                 920                 925             


Asn Ser Phe Tyr Thr Arg Lys Glu Ser Tyr Asp Tyr Gln Ala Ala Cys 
    930                 935                 940                 


Ala Pro Gln Pro Pro Gly Asn Leu Gly Ala Ala Pro Arg Gly Val Phe 
945                 950                 955                 960 


Val Pro Thr Val Ala Asp Phe Leu Asn Leu Ala Trp Trp Thr Ser Ala 
                965                 970                 975     


Ala Ala Trp Ser Leu Phe Gln Gln Leu Leu Tyr Gly Leu Ile Tyr His 
            980                 985                 990         


Ser Trp Phe Gln Ala Asp Pro Ala  Glu Ala Glu Gly Ser  Pro Glu Thr 
        995                 1000                 1005             


Arg Glu  Ser Ser Cys Val Met  Lys Gln Thr Gln Tyr  Tyr Phe Gly 
    1010                 1015                 1020             


Ser Val  Asn Ala Ser Tyr Asn  Ala Ile Ile Asp Cys  Gly Asn Cys 
    1025                 1030                 1035             


Ser Arg  Leu Phe His Ala Gln  Arg Leu Thr Asn Thr  Asn Leu Leu 
    1040                 1045                 1050             


Phe Val  Val Ala Glu Lys Pro  Leu Cys Ser Gln Cys  Glu Ala Gly 
    1055                 1060                 1065             


Arg Leu  Leu Gln Lys Glu Thr  His Ser Asp Gly Pro  Glu Gln Cys 
    1070                 1075                 1080             


Glu Leu  Val Gln Arg Pro Arg  Tyr Arg Arg Gly Pro  His Ile Cys 
    1085                 1090                 1095             


Phe Asp  Tyr Asn Ala Thr Glu  Asp Thr Ser Asp Cys  Gly Arg Gly 
    1100                 1105                 1110             


Ala Ser  Phe Pro Pro Ser Leu  Gly Val Leu Val Ser  Leu Gln Leu 
    1115                 1120                 1125             


Leu Leu  Leu Leu Gly Leu Pro  Pro Arg Pro Gln Pro  Gln Val Leu 
    1130                 1135                 1140             


Val His  Ala Ser Arg Arg Leu  
    1145                 1150 


<210>  23
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Met Lys Leu Arg His Lys Asn Lys Lys Pro Gly Glu Gly Ser Lys 
1               5                   10                  15      


Gly His Lys Lys Ile Ser Trp Pro Tyr Pro Gln Pro Ala Lys Gln Asn 
            20                  25                  30          


Gly Lys Lys Ala Thr Ser Lys Val Pro Ser Ala Pro His Phe Val His 
        35                  40                  45              


Pro Asn Asp His Ala Asn Arg Glu Ala Glu Leu Lys Lys Lys Trp Val 
    50                  55                  60                  


Glu Glu Met Arg Glu Lys Gln Gln Ala Ala Arg Glu Gln Glu Arg Gln 
65                  70                  75                  80  


Lys Arg Arg Thr Ile Glu Ser Tyr Cys Gln Asp Val Leu Arg Arg Gln 
                85                  90                  95      


Glu Glu Phe Glu His Lys Glu Glu Val Leu Gln Glu Leu Asn Met Phe 
            100                 105                 110         


Pro Gln Leu Asp Asp Glu Ala Thr Arg Lys Ala Tyr Tyr Lys Glu Phe 
        115                 120                 125             


Arg Lys Val Val Glu Tyr Ser Asp Val Ile Leu Glu Val Leu Asp Ala 
    130                 135                 140                 


Arg Asp Pro Leu Gly Cys Arg Cys Phe Gln Met Glu Glu Ala Val Leu 
145                 150                 155                 160 


Arg Ala Gln Gly Asn Lys Lys Leu Val Leu Val Leu Asn Lys Ile Asp 
                165                 170                 175     


Leu Val Pro Lys Glu Val Val Glu Lys Trp Leu Asp Tyr Leu Arg Asn 
            180                 185                 190         


Glu Leu Pro Thr Val Ala Phe Lys Ala Ser Thr Gln His Gln Val Lys 
        195                 200                 205             


Asn Leu Asn Arg Cys Ser Val Pro Val Asp Gln Ala Ser Glu Ser Leu 
    210                 215                 220                 


Leu Lys Ser Lys Ala Cys Phe Gly Ala Glu Asn Leu Met Arg Val Leu 
225                 230                 235                 240 


Gly Asn Tyr Cys Arg Leu Gly Glu Val Arg Thr His Ile Arg Val Gly 
                245                 250                 255     


Val Val Gly Leu Pro Asn Val Gly Lys Ser Ser Leu Ile Asn Ser Leu 
            260                 265                 270         


Lys Arg Ser Arg Ala Cys Ser Val Gly Ala Val Pro Gly Ile Thr Lys 
        275                 280                 285             


Phe Met Gln Glu Val Tyr Leu Asp Lys Phe Ile Arg Leu Leu Asp Ala 
    290                 295                 300                 


Pro Gly Ile Val Pro Gly Pro Asn Ser Glu Val Gly Thr Ile Leu Arg 
305                 310                 315                 320 


Asn Cys Val His Val Gln Lys Leu Ala Asp Pro Val Thr Pro Val Glu 
                325                 330                 335     


Thr Ile Leu Gln Arg Cys Asn Leu Glu Glu Ile Ser Asn Tyr Tyr Gly 
            340                 345                 350         


Val Ser Gly Phe Gln Thr Thr Glu His Phe Leu Thr Ala Val Ala His 
        355                 360                 365             


Arg Leu Gly Lys Lys Lys Lys Gly Gly Leu Tyr Ser Gln Glu Gln Ala 
    370                 375                 380                 


Ala Lys Ala Val Leu Ala Asp Trp Val Ser Gly Lys Ile Ser Phe Tyr 
385                 390                 395                 400 


Ile Pro Pro Pro Ala Thr His Thr Leu Pro Thr His Leu Ser Ala Glu 
                405                 410                 415     


Ile Val Lys Glu Met Thr Glu Val Phe Asp Ile Glu Asp Thr Glu Gln 
            420                 425                 430         


Ala Asn Glu Asp Thr Met Glu Cys Leu Ala Thr Gly Glu Ser Asp Glu 
        435                 440                 445             


Leu Leu Gly Asp Thr Asp Pro Leu Glu Met Glu Ile Lys Leu Leu His 
    450                 455                 460                 


Ser Pro Met Thr Lys Ile Ala Asp Ala Ile Glu Asn Lys Thr Thr Val 
465                 470                 475                 480 


Tyr Lys Ile Gly Asp Leu Thr Gly Tyr Cys Thr Asn Pro Asn Arg His 
                485                 490                 495     


Gln Met Gly Trp Ala Lys Arg Asn Val Asp His Arg Pro Lys Ser Asn 
            500                 505                 510         


Ser Met Val Asp Val Cys Ser Val Asp Arg Arg Ser Val Leu Gln Arg 
        515                 520                 525             


Ile Met Glu Thr Asp Pro Leu Gln Gln Gly Gln Ala Leu Ala Ser Ala 
    530                 535                 540                 


Leu Lys Asn Lys Lys Lys Met Gln Lys Arg Ala Asp Lys Ile Ala Ser 
545                 550                 555                 560 


Lys Leu Ser Asp Ser Met Met Ser Ala Leu Asp Leu Ser Gly Asn Ala 
                565                 570                 575     


Asp Asp Gly Val Gly Asp 
            580         


<210>  24
<211>  1487
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 
        35                  40                  45              


Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 
    50                  55                  60                  


Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 
65                  70                  75                  80  


Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 
                85                  90                  95      


Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 
            100                 105                 110         


Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 
    130                 135                 140                 


Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 
                165                 170                 175     


Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 
            180                 185                 190         


Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 
        195                 200                 205             


Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
    210                 215                 220                 


Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 
225                 230                 235                 240 


Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 
                245                 250                 255     


Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 
            260                 265                 270         


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 
        275                 280                 285             


His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 
    290                 295                 300                 


Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 
305                 310                 315                 320 


Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 
                325                 330                 335     


Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 
    370                 375                 380                 


Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 
                405                 410                 415     


Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 
            420                 425                 430         


Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 
        435                 440                 445             


Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 
    450                 455                 460                 


Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 
465                 470                 475                 480 


Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 
                485                 490                 495     


Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 
        515                 520                 525             


Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 
    530                 535                 540                 


Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 
545                 550                 555                 560 


Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 
                565                 570                 575     


Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
            580                 585                 590         


Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 
        595                 600                 605             


Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 
    610                 615                 620                 


Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 
625                 630                 635                 640 


Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 
                645                 650                 655     


Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 
    690                 695                 700                 


Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 
                725                 730                 735     


Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 
            740                 745                 750         


Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 
        755                 760                 765             


Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 
    770                 775                 780                 


Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 
                805                 810                 815     


Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 
            820                 825                 830         


Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 
        835                 840                 845             


Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 
865                 870                 875                 880 


Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 
                885                 890                 895     


Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 
        915                 920                 925             


Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
    930                 935                 940                 


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
945                 950                 955                 960 


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 
                965                 970                 975     


Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 
            980                 985                 990         


Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 
        995                 1000                 1005             


Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 
    1010                 1015                 1020             


Pro Pro  Gly Leu Thr Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 
    1040                 1045                 1050             


Val Lys  Gly Asp Arg Gly Glu  Thr Gly Ala Val Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Thr Gly 
    1070                 1075                 1080             


Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 
    1085                 1090                 1095             


Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 
    1100                 1105                 1110             


Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 
    1115                 1120                 1125             


Leu Lys  Gly His Arg Gly Phe  Thr Gly Leu Gln Gly  Leu Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 
    1145                 1150                 1155             


Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 
    1160                 1165                 1170             


Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Arg  Gly Arg Ser Gly Glu  Thr Gly Pro Ala Gly  Pro Pro Gly 
    1190                 1195                 1200             


Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 
    1205                 1210                 1215             


Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 
    1220                 1225                 1230             


Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 
    1235                 1240                 1245             


Arg Gln  His Asp Ala Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1250                 1255                 1260             


Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 
    1265                 1270                 1275             


Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 
    1280                 1285                 1290             


Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Leu 
    1295                 1300                 1305             


Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Thr Gly  Glu Thr Cys 
    1310                 1315                 1320             


Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 
    1325                 1330                 1335             


Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Thr Ile 
    1340                 1345                 1350             


Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 
    1355                 1360                 1365             


Asn Thr  Ala Asn Val Gln Met  Thr Phe Leu Arg Leu  Leu Ser Thr 
    1370                 1375                 1380             


Glu Gly  Ser Gln Asn Ile Thr  Tyr His Cys Lys Asn  Ser Ile Ala 
    1385                 1390                 1395             


Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 
    1400                 1405                 1410             


Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 
    1415                 1420                 1425             


Phe Thr  Tyr Thr Ala Leu Lys  Asp Gly Cys Thr Lys  His Thr Gly 
    1430                 1435                 1440             


Lys Trp  Gly Lys Thr Val Ile  Glu Tyr Arg Ser Gln  Lys Thr Ser 
    1445                 1450                 1455             


Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 
    1460                 1465                 1470             


Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 
    1475                 1480                 1485         


<210>  25
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Pro His Ser Val Thr Leu Arg Gly Pro Ser Pro Trp Gly Phe Arg 
1               5                   10                  15      


Leu Val Gly Gly Arg Asp Phe Ser Ala Pro Leu Thr Ile Ser Arg Val 
            20                  25                  30          


His Ala Gly Ser Lys Ala Ala Leu Ala Ala Leu Cys Pro Gly Asp Leu 
        35                  40                  45              


Ile Gln Ala Ile Asn Gly Glu Ser Thr Glu Leu Met Thr His Leu Glu 
    50                  55                  60                  


Ala Gln Asn Arg Ile Lys Gly Cys His Asp His Leu Thr Leu Ser Val 
65                  70                  75                  80  


Ser Arg Pro Glu Gly Arg Ser Trp Pro Ser Ala Pro Asp Asp Ser Lys 
                85                  90                  95      


Ala Gln Ala His Arg Ile His Ile Asp Pro Glu Ile Gln Asp Gly Ser 
            100                 105                 110         


Pro Thr Thr Ser Arg Arg Pro Ser Gly Thr Gly Thr Gly Pro Glu Asp 
        115                 120                 125             


Gly Arg Pro Ser Leu Gly Ser Pro Tyr Gly Gln Pro Pro Arg Phe Pro 
    130                 135                 140                 


Val Pro His Asn Gly Ser Ser Glu Ala Thr Leu Pro Ala Gln Met Ser 
145                 150                 155                 160 


Thr Leu His Val Ser Pro Pro Pro Ser Ala Asp Pro Ala Arg Gly Leu 
                165                 170                 175     


Pro Arg Ser Arg Asp Cys Arg Val Asp Leu Gly Ser Glu Val Tyr Arg 
            180                 185                 190         


Met Leu Arg Glu Pro Ala Glu Pro Val Ala Ala Glu Pro Lys Gln Ser 
        195                 200                 205             


Gly Ser Phe Arg Tyr Leu Gln Gly Met Leu Glu Ala Gly Glu Gly Gly 
    210                 215                 220                 


Asp Trp Pro Gly Pro Gly Gly Pro Arg Asn Leu Lys Pro Thr Ala Ser 
225                 230                 235                 240 


Lys Leu Gly Ala Pro Leu Ser Gly Leu Gln Gly Leu Pro Glu Cys Thr 
                245                 250                 255     


Arg Cys Gly His Gly Ile Val Gly Thr Ile Val Lys Ala Arg Asp Lys 
            260                 265                 270         


Leu Tyr His Pro Glu Cys Phe Met Cys Ser Asp Cys Gly Leu Asn Leu 
        275                 280                 285             


Lys Gln Arg Gly Tyr Phe Phe Leu Asp Glu Arg Leu Tyr Cys Glu Ser 
    290                 295                 300                 


His Ala Lys Ala Arg Val Lys Pro Pro Glu Gly Tyr Asp Val Val Ala 
305                 310                 315                 320 


Val Tyr Pro Asn Ala Lys Val Glu Leu Val 
                325                 330 


<210>  26
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Glu Arg Ile Trp Ala Pro Pro Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Pro Pro Pro Leu Trp Gly Gly Pro Pro Asp Ser Pro Arg Arg 
            20                  25                  30          


Glu Leu Glu Leu Glu Pro Gly Pro Leu Gln Pro Phe Asp Leu Leu Tyr 
        35                  40                  45              


Ala Ser Gly Ala Ala Ala Tyr Tyr Ser Gly Asp Tyr Glu Arg Ala Val 
    50                  55                  60                  


Arg Asp Leu Glu Ala Ala Leu Arg Ser His Arg Arg Leu Arg Glu Ile 
65                  70                  75                  80  


Arg Thr Arg Cys Ala Arg His Cys Ala Ala Arg His Pro Leu Pro Pro 
                85                  90                  95      


Pro Pro Pro Gly Glu Gly Pro Gly Ala Glu Leu Pro Leu Phe Arg Ser 
            100                 105                 110         


Leu Leu Gly Arg Ala Arg Cys Tyr Arg Ser Cys Glu Thr Gln Arg Leu 
        115                 120                 125             


Gly Gly Pro Ala Ser Arg His Arg Val Ser Glu Asp Val Arg Ser Asp 
    130                 135                 140                 


Phe Gln Arg Arg Val Pro Tyr Asn Tyr Leu Gln Arg Ala Tyr Ile Lys 
145                 150                 155                 160 


Leu Asn Gln Leu Glu Lys Ala Val Glu Ala Ala His Thr Phe Phe Val 
                165                 170                 175     


Ala Asn Pro Glu His Met Glu Met Gln Gln Asn Ile Glu Asn Tyr Arg 
            180                 185                 190         


Ala Thr Ala Gly Val Glu Ala Leu Gln Leu Val Asp Arg Glu Ala Lys 
        195                 200                 205             


Pro His Met Glu Ser Tyr Asn Ala Gly Val Lys His Tyr Glu Ala Asp 
    210                 215                 220                 


Asp Phe Glu Met Ala Ile Arg His Phe Glu Gln Ala Leu Arg Glu Tyr 
225                 230                 235                 240 


Phe Val Glu Asp Thr Glu Cys Arg Thr Leu Cys Glu Gly Pro Gln Arg 
                245                 250                 255     


Phe Glu Glu Tyr Glu Tyr Leu Gly Tyr Lys Ala Gly Leu Tyr Glu Ala 
            260                 265                 270         


Ile Ala Asp His Tyr Met Gln Val Leu Val Cys Gln His Glu Cys Val 
        275                 280                 285             


Arg Glu Leu Ala Thr Arg Pro Gly Arg Leu Ser Pro Ile Glu Asn Phe 
    290                 295                 300                 


Leu Pro Leu His Tyr Asp Tyr Leu Gln Phe Ala Tyr Tyr Arg Val Gly 
305                 310                 315                 320 


Glu Tyr Val Lys Ala Leu Glu Cys Ala Lys Ala Tyr Leu Leu Cys His 
                325                 330                 335     


Pro Asp Asp Glu Asp Val Leu Asp Asn Val Asp Tyr Tyr Glu Ser Leu 
            340                 345                 350         


Leu Asp Asp Ser Ile Asp Pro Ala Ser Ile Glu Ala Arg Glu Asp Leu 
        355                 360                 365             


Thr Met Phe Val Lys Arg His Lys Leu Glu Ser Glu Leu Ile Lys Ser 
    370                 375                 380                 


Ala Ala Glu Gly Leu Gly Phe Ser Tyr Thr Glu Pro Asn Tyr Trp Ile 
385                 390                 395                 400 


Arg Tyr Gly Gly Arg Gln Asp Glu Asn Arg Val Pro Ser Gly Val Asn 
                405                 410                 415     


Val Glu Gly Ala Glu Val His Gly Phe Ser Met Gly Lys Lys Leu Ser 
            420                 425                 430         


Pro Lys Ile Asp Arg Asp Leu Arg Glu Gly Gly Pro Leu Leu Tyr Glu 
        435                 440                 445             


Asn Ile Thr Phe Val Tyr Asn Ser Glu Gln Leu Asn Gly Thr Gln Arg 
    450                 455                 460                 


Val Leu Leu Asp Asn Val Leu Ser Glu Glu Gln Cys Arg Glu Leu His 
465                 470                 475                 480 


Ser Val Ala Ser Gly Ile Met Leu Val Gly Asp Gly Tyr Arg Gly Lys 
                485                 490                 495     


Thr Ser Pro His Thr Pro Asn Glu Lys Phe Glu Gly Ala Thr Val Leu 
            500                 505                 510         


Lys Ala Leu Lys Ser Gly Tyr Glu Gly Arg Val Pro Leu Lys Ser Ala 
        515                 520                 525             


Arg Leu Phe Tyr Asp Ile Ser Glu Lys Ala Arg Arg Ile Val Glu Ser 
    530                 535                 540                 


Tyr Phe Met Leu Asn Ser Thr Leu Tyr Phe Ser Tyr Thr His Met Val 
545                 550                 555                 560 


Cys Arg Thr Ala Leu Ser Gly Gln Gln Asp Arg Arg Asn Asp Leu Ser 
                565                 570                 575     


His Pro Ile His Ala Asp Asn Cys Leu Leu Asp Pro Glu Ala Asn Glu 
            580                 585                 590         


Cys Trp Lys Glu Pro Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala Leu 
        595                 600                 605             


Leu Tyr Met Asn Asp Asp Phe Glu Gly Gly Glu Phe Ile Phe Thr Glu 
    610                 615                 620                 


Met Asp Ala Lys Thr Val Thr Ala Ser Ile Lys Pro Lys Cys Gly Arg 
625                 630                 635                 640 


Met Ile Ser Phe Ser Ser Gly Gly Glu Asn Pro His Gly Val Lys Ala 
                645                 650                 655     


Val Thr Lys Gly Lys Arg Cys Ala Val Ala Leu Trp Phe Thr Leu Asp 
            660                 665                 670         


Pro Leu Tyr Arg Glu Leu Glu Arg Ile Gln Ala Asp Glu Val Ile Ala 
        675                 680                 685             


Ile Leu Asp Gln Glu Gln Gln Gly Lys His Glu Leu Asn Ile Asn Pro 
    690                 695                 700                 


Lys Asp Glu Leu 
705             


<210>  27
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Phe Leu Ser Pro Ile Tyr Val Ile Phe Phe Phe Phe Gly Val 
1               5                   10                  15      


Lys Val His Cys Gln Tyr Glu Thr Tyr Gln Trp Asp Glu Asp Tyr Asp 
            20                  25                  30          


Gln Glu Pro Asp Asp Asp Tyr Gln Thr Gly Phe Pro Phe Arg Gln Asn 
        35                  40                  45              


Val Asp Tyr Gly Val Pro Phe His Gln Tyr Thr Leu Gly Cys Val Ser 
    50                  55                  60                  


Glu Cys Phe Cys Pro Thr Asn Phe Pro Ser Ser Met Tyr Cys Asp Asn 
65                  70                  75                  80  


Arg Lys Leu Lys Thr Ile Pro Asn Ile Pro Met His Ile Gln Gln Leu 
                85                  90                  95      


Tyr Leu Gln Phe Asn Glu Ile Glu Ala Val Thr Ala Asn Ser Phe Ile 
            100                 105                 110         


Asn Ala Thr His Leu Lys Glu Ile Asn Leu Ser His Asn Lys Ile Lys 
        115                 120                 125             


Ser Gln Lys Ile Asp Tyr Gly Val Phe Ala Lys Leu Pro Asn Leu Leu 
    130                 135                 140                 


Gln Leu His Leu Glu His Asn Asn Leu Glu Glu Phe Pro Phe Pro Leu 
145                 150                 155                 160 


Pro Lys Ser Leu Glu Arg Leu Leu Leu Gly Tyr Asn Glu Ile Ser Lys 
                165                 170                 175     


Leu Gln Thr Asn Ala Met Asp Gly Leu Val Asn Leu Thr Met Leu Asp 
            180                 185                 190         


Leu Cys Tyr Asn Tyr Leu His Asp Ser Leu Leu Lys Asp Lys Ile Phe 
        195                 200                 205             


Ala Lys Met Glu Lys Leu Met Gln Leu Asn Leu Cys Ser Asn Arg Leu 
    210                 215                 220                 


Glu Ser Met Pro Pro Gly Leu Pro Ser Ser Leu Met Tyr Leu Ser Leu 
225                 230                 235                 240 


Glu Asn Asn Ser Ile Ser Ser Ile Pro Glu Lys Tyr Phe Asp Lys Leu 
                245                 250                 255     


Pro Lys Leu His Thr Leu Arg Met Ser His Asn Lys Leu Gln Asp Ile 
            260                 265                 270         


Pro Tyr Asn Ile Phe Asn Leu Pro Asn Ile Val Glu Leu Ser Val Gly 
        275                 280                 285             


His Asn Lys Leu Lys Gln Ala Phe Tyr Ile Pro Arg Asn Leu Glu His 
    290                 295                 300                 


Leu Tyr Leu Gln Asn Asn Glu Ile Glu Lys Met Asn Leu Thr Val Met 
305                 310                 315                 320 


Cys Pro Ser Ile Asp Pro Leu His Tyr His His Leu Thr Tyr Ile Arg 
                325                 330                 335     


Val Asp Gln Asn Lys Leu Lys Glu Pro Ile Ser Ser Tyr Ile Phe Phe 
            340                 345                 350         


Cys Phe Pro His Ile His Thr Ile Tyr Tyr Gly Glu Gln Arg Ser Thr 
        355                 360                 365             


Asn Gly Gln Thr Ile Gln Leu Lys Thr Gln Val Phe Arg Arg Phe Pro 
    370                 375                 380                 


Asp Asp Asp Asp Glu Ser Glu Asp His Asp Asp Pro Asp Asn Ala His 
385                 390                 395                 400 


Glu Ser Pro Glu Gln Glu Gly Ala Glu Gly His Phe Asp Leu His Tyr 
                405                 410                 415     


Tyr Glu Asn Gln Glu 
            420     


<210>  28
<211>  1117
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Thr Phe Phe Arg Arg His Phe Arg Gly Lys Val Pro Gly Pro 
1               5                   10                  15      


Gly Glu Gly Gln Gln Arg Pro Ser Ser Val Gly Leu Pro Thr Gly Lys 
            20                  25                  30          


Ala Arg Arg Arg Ser Pro Ala Gly Gln Ala Ser Ser Ser Leu Ala Gln 
        35                  40                  45              


Arg Arg Arg Ser Ser Ala Gln Leu Gln Gly Cys Leu Leu Ser Cys Gly 
    50                  55                  60                  


Val Arg Ala Gln Gly Ser Ser Arg Arg Arg Ser Ser Thr Val Pro Pro 
65                  70                  75                  80  


Ser Cys Asn Pro Arg Phe Ile Val Asp Lys Val Leu Thr Pro Gln Pro 
                85                  90                  95      


Thr Thr Val Gly Ala Gln Leu Leu Gly Ala Pro Leu Leu Leu Thr Gly 
            100                 105                 110         


Leu Val Gly Met Asn Glu Glu Glu Gly Val Gln Glu Asp Val Val Ala 
        115                 120                 125             


Glu Ala Ser Ser Ala Ile Gln Pro Gly Thr Lys Thr Pro Gly Pro Pro 
    130                 135                 140                 


Pro Pro Arg Gly Ala Gln Pro Leu Leu Pro Leu Pro Arg Tyr Leu Arg 
145                 150                 155                 160 


Arg Ala Ser Ser His Leu Leu Pro Ala Asp Ala Val Tyr Asp His Ala 
                165                 170                 175     


Leu Trp Gly Leu His Gly Tyr Tyr Arg Arg Leu Ser Gln Arg Arg Pro 
            180                 185                 190         


Ser Gly Gln His Pro Gly Pro Gly Gly Arg Arg Ala Ser Gly Thr Thr 
        195                 200                 205             


Ala Gly Thr Met Leu Pro Thr Arg Val Arg Pro Leu Ser Arg Arg Arg 
    210                 215                 220                 


Gln Val Ala Leu Arg Arg Lys Ala Ala Gly Pro Gln Ala Trp Ser Ala 
225                 230                 235                 240 


Leu Leu Ala Lys Ala Ile Thr Lys Ser Gly Leu Gln His Leu Ala Pro 
                245                 250                 255     


Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu Arg Gln Ile 
            260                 265                 270         


Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly Glu His Ile 
        275                 280                 285             


Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val Gly Glu Gln 
    290                 295                 300                 


Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg Lys Cys Ala 
305                 310                 315                 320 


Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln Leu Glu Lys 
                325                 330                 335     


Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly Ser Arg Asn 
            340                 345                 350         


Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His Arg Arg Arg 
        355                 360                 365             


Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln Gln Lys Phe 
    370                 375                 380                 


Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp Cys Lys 
385                 390                 395                 400 


Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln Gln Ile Glu 
                405                 410                 415     


Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile Pro Pro Thr 
            420                 425                 430         


Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys Ala Ser Lys 
        435                 440                 445             


Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys Lys Gly Pro 
    450                 455                 460                 


Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr Pro Ser Pro 
465                 470                 475                 480 


Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Asn 
                485                 490                 495     


Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu Asn Pro Arg 
            500                 505                 510         


Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala Leu Glu Met 
        515                 520                 525             


Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly Gly Asp Gly 
    530                 535                 540                 


Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg Leu Lys Pro 
545                 550                 555                 560 


Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala 
                565                 570                 575     


Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro Val Ser Lys 
            580                 585                 590         


Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu Asp Arg Trp 
        595                 600                 605             


Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu Asp Arg Asp 
    610                 615                 620                 


Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn Asn Tyr Phe 
625                 630                 635                 640 


Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His Glu Ser Arg 
                645                 650                 655     


Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn Lys Met Phe 
            660                 665                 670         


Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser Ser Lys Asp 
        675                 680                 685             


Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp Leu Thr Pro 
    690                 695                 700                 


Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu Asn Ile Pro 
705                 710                 715                 720 


Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly Glu His His 
                725                 730                 735     


Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu Val Ile Gly 
            740                 745                 750         


Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly His Gly Glu 
        755                 760                 765             


Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser Lys Ala Ile 
    770                 775                 780                 


Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala Ser Arg Ile 
785                 790                 795                 800 


Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys Ala Lys Arg 
                805                 810                 815     


Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val Pro Glu Gln 
            820                 825                 830         


Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr Glu Ala Leu 
        835                 840                 845             


His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro Leu Gly Thr 
    850                 855                 860                 


Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg Ala His Ile 
865                 870                 875                 880 


Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys Ser Pro Thr 
                885                 890                 895     


Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala Thr Thr Ala 
            900                 905                 910         


Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu Asn Tyr Val 
        915                 920                 925             


Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro Glu Leu Leu 
    930                 935                 940                 


Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser Pro Leu Pro 
945                 950                 955                 960 


Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly Asp Ala Ala 
                965                 970                 975     


Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg Asn Asp Phe 
            980                 985                 990         


Cys Lys Leu Gln Glu Leu His Arg  Ala Gly Gly Asp Leu  Met His Arg 
        995                 1000                 1005             


Asp Glu  Gln Ser Arg Thr Leu  Leu His His Ala Val  Ser Thr Gly 
    1010                 1015                 1020             


Ser Lys  Asp Val Val Arg Tyr  Leu Leu Asp His Ala  Pro Pro Glu 
    1025                 1030                 1035             


Ile Leu  Asp Ala Val Glu Glu  Asn Gly Glu Thr Cys  Leu His Gln 
    1040                 1045                 1050             


Ala Ala  Ala Leu Gly Gln Arg  Thr Ile Cys His Tyr  Ile Val Glu 
    1055                 1060                 1065             


Ala Gly  Ala Ser Leu Met Lys  Thr Asp Gln Gln Gly  Asp Thr Pro 
    1070                 1075                 1080             


Arg Gln  Arg Ala Glu Lys Ala  Gln Asp Thr Glu Leu  Ala Ala Tyr 
    1085                 1090                 1095             


Leu Glu  Asn Arg Gln His Tyr  Gln Met Ile Gln Arg  Glu Asp Gln 
    1100                 1105                 1110             


Glu Thr  Ala Val 
    1115         


<210>  29
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Val Glu Ser Gly Ser Ala Gln Glu Arg Gly Ile Leu Leu Glu 
1               5                   10                  15      


Ser Leu Ser Thr Leu Leu Glu Lys Thr Thr Ala Ser His Glu Gly Arg 
            20                  25                  30          


Ala Pro Gly Asn Arg Glu Leu Thr Asp Leu Leu Pro Pro Glu Val Cys 
        35                  40                  45              


Ser Leu Leu Asn Pro Ala Ala Ile Tyr Ala Asn Asn Glu Ile Ser Leu 
    50                  55                  60                  


Arg Asp Val Glu Val Tyr Gly Phe Asp Tyr Asp Tyr Thr Leu Ala Gln 
65                  70                  75                  80  


Tyr Ala Asp Ala Leu His Pro Glu Ile Phe Ser Thr Ala Arg Asp Ile 
                85                  90                  95      


Leu Ile Glu His Tyr Lys Tyr Pro Glu Gly Ile Arg Lys Tyr Asp Tyr 
            100                 105                 110         


Asn Pro Ser Phe Ala Ile Arg Gly Leu His Tyr Asp Ile Gln Lys Ser 
        115                 120                 125             


Leu Leu Met Lys Ile Asp Ala Phe His Tyr Val Gln Leu Gly Thr Ala 
    130                 135                 140                 


Tyr Arg Gly Leu Gln Pro Val Pro Asp Glu Glu Val Ile Glu Leu Tyr 
145                 150                 155                 160 


Gly Gly Thr Gln His Ile Pro Leu Tyr Gln Met Ser Gly Phe Tyr Gly 
                165                 170                 175     


Lys Gly Pro Ser Ile Lys Gln Phe Met Asp Ile Phe Ser Leu Pro Glu 
            180                 185                 190         


Met Ala Leu Leu Ser Cys Val Val Asp Tyr Phe Leu Gly His Ser Leu 
        195                 200                 205             


Glu Phe Asp Gln Ala His Leu Tyr Lys Asp Val Thr Asp Ala Ile Arg 
    210                 215                 220                 


Asp Val His Val Lys Gly Leu Met Tyr Gln Trp Ile Glu Gln Asp Met 
225                 230                 235                 240 


Glu Lys Tyr Ile Leu Arg Gly Asp Glu Thr Phe Ala Val Leu Ser Arg 
                245                 250                 255     


Leu Val Ala His Gly Lys Gln Leu Phe Leu Ile Thr Asn Ser Pro Phe 
            260                 265                 270         


Ser Phe Val Asp Lys Gly Met Arg His Met Val Gly Pro Asp Trp Arg 
        275                 280                 285             


Gln Leu Phe Asp Val Val Ile Val Gln Ala Asp Lys Pro Ser Phe Phe 
    290                 295                 300                 


Thr Asp Arg Arg Lys Pro Phe Arg Lys Leu Asp Glu Lys Gly Ser Leu 
305                 310                 315                 320 


Gln Trp Asp Arg Ile Thr Arg Leu Glu Lys Gly Lys Ile Tyr Arg Gln 
                325                 330                 335     


Gly Asn Leu Phe Asp Phe Leu Arg Leu Thr Glu Trp Arg Gly Pro Arg 
            340                 345                 350         


Val Leu Tyr Phe Gly Asp His Leu Tyr Ser Asp Leu Ala Asp Leu Met 
        355                 360                 365             


Leu Arg His Gly Trp Arg Thr Gly Ala Ile Ile Pro Glu Leu Glu Arg 
    370                 375                 380                 


Glu Ile Arg Ile Ile Asn Thr Glu Gln Tyr Met His Ser Leu Thr Trp 
385                 390                 395                 400 


Gln Gln Ala Leu Thr Gly Leu Leu Glu Arg Met Gln Thr Tyr Gln Asp 
                405                 410                 415     


Ala Glu Ser Arg Gln Val Leu Ala Ala Trp Met Lys Glu Arg Gln Glu 
            420                 425                 430         


Leu Arg Cys Ile Thr Lys Ala Leu Phe Asn Ala Gln Phe Gly Ser Ile 
        435                 440                 445             


Phe Arg Thr Phe His Asn Pro Thr Tyr Phe Ser Arg Arg Leu Val Arg 
    450                 455                 460                 


Phe Ser Asp Leu Tyr Met Ala Ser Leu Ser Cys Leu Leu Asn Tyr Arg 
465                 470                 475                 480 


Val Asp Phe Thr Phe Tyr Pro Arg Arg Thr Pro Leu Gln His Glu Ala 
                485                 490                 495     


Pro Leu Trp Met Asp Gln Leu Cys Thr Gly Cys Met Lys Thr Pro Phe 
            500                 505                 510         


Leu Gly Asp Met Ala His Ile Arg 
        515                 520 


<210>  30
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asn Gln Leu Ser Phe Leu Leu Phe Leu Ile Ala Thr Thr Arg Gly 
1               5                   10                  15      


Trp Ser Thr Asp Glu Ala Asn Thr Tyr Phe Lys Glu Trp Thr Cys Ser 
            20                  25                  30          


Ser Ser Pro Ser Leu Pro Arg Ser Cys Lys Glu Ile Lys Asp Glu Cys 
        35                  40                  45              


Pro Ser Ala Phe Asp Gly Leu Tyr Phe Leu Arg Thr Glu Asn Gly Val 
    50                  55                  60                  


Ile Tyr Gln Thr Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr 
65                  70                  75                  80  


Leu Val Ala Ser Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val 
                85                  90                  95      


Gly Asp Arg Trp Ser Ser Gln Gln Gly Ser Lys Ala Val Tyr Pro Glu 
            100                 105                 110         


Gly Asp Gly Asn Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala 
        115                 120                 125             


Ala Thr Ser Asp Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala 
    130                 135                 140                 


Lys Asp Leu Gly Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His 
145                 150                 155                 160 


Trp Arg Asn Ser Ser Leu Leu Arg Tyr Arg Thr Asp Thr Gly Phe Leu 
                165                 170                 175     


Gln Thr Leu Gly His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val 
            180                 185                 190         


Lys Tyr Gly Glu Gly Lys Cys Trp Thr Asp Asn Gly Pro Val Ile Pro 
        195                 200                 205             


Val Val Tyr Asp Phe Gly Asp Ala Gln Lys Thr Ala Ser Tyr Tyr Ser 
    210                 215                 220                 


Pro Tyr Gly Gln Arg Glu Phe Thr Ala Gly Phe Val Gln Phe Arg Val 
225                 230                 235                 240 


Phe Asn Asn Glu Arg Ala Ala Asn Ala Leu Cys Ala Gly Met Arg Val 
                245                 250                 255     


Thr Gly Cys Asn Thr Glu His His Cys Ile Gly Gly Gly Gly Tyr Phe 
            260                 265                 270         


Pro Glu Ala Ser Pro Gln Gln Cys Gly Asp Phe Ser Gly Phe Asp Trp 
        275                 280                 285             


Ser Gly Tyr Gly Thr His Val Gly Tyr Ser Ser Ser Arg Glu Ile Thr 
    290                 295                 300                 


Glu Ala Ala Val Leu Leu Phe Tyr Arg 
305                 310             


<210>  31
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
                85                  90                  95      


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
    130                 135                 140                 


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
                165                 170                 175     


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
            180                 185                 190         


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
        195                 200                 205             


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
    210                 215                 220                 


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
225                 230                 235                 240 


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
                245                 250                 255     


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
            260                 265                 270         


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
        275                 280                 285             


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
    290                 295                 300                 


Asn Ala Ser Ile Met Leu Phe Gly Pro Gly Ala Val Ser Glu Val Ser 
305                 310                 315                 320 


Asn Gly Thr Ser Arg Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu 
                325                 330                 335     


Val Leu His Leu Leu Leu Lys Phe 
            340                 


<210>  32
<211>  762
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Asn Gly Ser Val Lys Pro Lys His Ser Lys His Pro Asp Gly 
1               5                   10                  15      


His Ser Gly Asn Leu Thr Thr Asp Ala Leu Arg Asn Lys Val Thr Glu 
            20                  25                  30          


Leu Glu Arg Glu Leu Arg Arg Lys Asp Ala Glu Ile Gln Glu Arg Glu 
        35                  40                  45              


Tyr His Leu Lys Glu Leu Arg Glu Gln Leu Ser Lys Gln Thr Val Ala 
    50                  55                  60                  


Ile Ala Glu Leu Thr Glu Glu Leu Gln Asn Lys Cys Ile Gln Leu Asn 
65                  70                  75                  80  


Lys Leu Gln Asp Val Val His Met Gln Gly Gly Ser Pro Leu Gln Ala 
                85                  90                  95      


Ser Pro Asp Lys Val Pro Leu Glu Val His Arg Lys Thr Ser Gly Leu 
            100                 105                 110         


Val Ser Leu His Ser Arg Arg Gly Ala Lys Ala Gly Val Ser Ala Glu 
        115                 120                 125             


Pro Thr Thr Arg Thr Tyr Asp Leu Asn Lys Pro Pro Glu Phe Ser Phe 
    130                 135                 140                 


Glu Lys Ala Arg Val Arg Lys Asp Ser Ser Glu Lys Lys Leu Ile Thr 
145                 150                 155                 160 


Asp Ala Leu Asn Lys Asn Gln Phe Leu Lys Arg Leu Asp Pro Gln Gln 
                165                 170                 175     


Ile Lys Asp Met Val Glu Cys Met Tyr Gly Arg Asn Tyr Gln Gln Gly 
            180                 185                 190         


Ser Tyr Ile Ile Lys Gln Gly Glu Pro Gly Asn His Ile Phe Val Leu 
        195                 200                 205             


Ala Glu Gly Arg Leu Glu Val Phe Gln Gly Glu Lys Leu Leu Ser Ser 
    210                 215                 220                 


Ile Pro Met Trp Thr Thr Phe Gly Glu Leu Ala Ile Leu Tyr Asn Cys 
225                 230                 235                 240 


Thr Arg Thr Ala Ser Val Lys Ala Ile Thr Asn Val Lys Thr Trp Ala 
                245                 250                 255     


Leu Asp Arg Glu Val Phe Gln Asn Ile Met Arg Arg Thr Ala Gln Ala 
            260                 265                 270         


Arg Asp Glu Gln Tyr Arg Asn Phe Leu Arg Ser Val Ser Leu Leu Lys 
        275                 280                 285             


Asn Leu Pro Glu Asp Lys Leu Thr Lys Ile Ile Asp Cys Leu Glu Val 
    290                 295                 300                 


Glu Tyr Tyr Asp Lys Gly Asp Tyr Ile Ile Arg Glu Gly Glu Glu Gly 
305                 310                 315                 320 


Ser Thr Phe Phe Ile Leu Ala Lys Gly Lys Val Lys Val Thr Gln Ser 
                325                 330                 335     


Thr Glu Gly His Asp Gln Pro Gln Leu Ile Lys Thr Leu Gln Lys Gly 
            340                 345                 350         


Glu Tyr Phe Gly Glu Lys Ala Leu Ile Ser Asp Asp Val Arg Ser Ala 
        355                 360                 365             


Asn Ile Ile Ala Glu Glu Asn Asp Val Ala Cys Leu Val Ile Asp Arg 
    370                 375                 380                 


Glu Thr Phe Asn Gln Thr Val Gly Thr Phe Glu Glu Leu Gln Lys Tyr 
385                 390                 395                 400 


Leu Glu Gly Tyr Val Ala Asn Leu Asn Arg Asp Asp Glu Lys Arg His 
                405                 410                 415     


Ala Lys Arg Ser Met Ser Asn Trp Lys Leu Ser Lys Ala Leu Ser Leu 
            420                 425                 430         


Glu Met Ile Gln Leu Lys Glu Lys Val Ala Arg Phe Ser Ser Ser Ser 
        435                 440                 445             


Pro Phe Gln Asn Leu Glu Ile Ile Ala Thr Leu Gly Val Gly Gly Phe 
    450                 455                 460                 


Gly Arg Val Glu Leu Val Lys Val Lys Asn Glu Asn Val Ala Phe Ala 
465                 470                 475                 480 


Met Lys Cys Ile Arg Lys Lys His Ile Val Asp Thr Lys Gln Gln Glu 
                485                 490                 495     


His Val Tyr Ser Glu Lys Arg Ile Leu Glu Glu Leu Cys Ser Pro Phe 
            500                 505                 510         


Ile Val Lys Leu Tyr Arg Thr Phe Lys Asp Asn Lys Tyr Val Tyr Met 
        515                 520                 525             


Leu Leu Glu Ala Cys Leu Gly Gly Glu Leu Trp Ser Ile Leu Arg Asp 
    530                 535                 540                 


Arg Gly Ser Phe Asp Glu Pro Thr Ser Lys Phe Cys Val Ala Cys Val 
545                 550                 555                 560 


Thr Glu Ala Phe Asp Tyr Leu His Arg Leu Gly Ile Ile Tyr Arg Asp 
                565                 570                 575     


Leu Lys Pro Glu Asn Leu Ile Leu Asp Ala Glu Gly Tyr Leu Lys Leu 
            580                 585                 590         


Val Asp Phe Gly Phe Ala Lys Lys Ile Gly Ser Gly Gln Lys Thr Trp 
        595                 600                 605             


Thr Phe Cys Gly Thr Pro Glu Tyr Val Ala Pro Glu Val Ile Leu Asn 
    610                 615                 620                 


Lys Gly His Asp Phe Ser Val Asp Phe Trp Ser Leu Gly Ile Leu Val 
625                 630                 635                 640 


Tyr Glu Leu Leu Thr Gly Asn Pro Pro Phe Ser Gly Val Asp Gln Met 
                645                 650                 655     


Met Thr Tyr Asn Leu Ile Leu Lys Gly Ile Glu Lys Met Asp Phe Pro 
            660                 665                 670         


Arg Lys Ile Thr Arg Arg Pro Glu Asp Leu Ile Arg Arg Leu Cys Arg 
        675                 680                 685             


Gln Asn Pro Thr Glu Arg Leu Gly Asn Leu Lys Asn Gly Ile Asn Asp 
    690                 695                 700                 


Ile Lys Lys His Arg Trp Leu Asn Gly Phe Asn Trp Glu Gly Leu Lys 
705                 710                 715                 720 


Ala Arg Ser Leu Pro Ser Pro Leu Gln Arg Glu Leu Lys Gly Pro Ile 
                725                 730                 735     


Asp His Ser Tyr Phe Asp Lys Tyr Pro Pro Glu Lys Gly Met Pro Pro 
            740                 745                 750         


Asp Glu Leu Ser Gly Trp Asp Lys Asp Phe 
        755                 760         


<210>  33
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gln Pro Thr Leu Leu Leu Ser Leu Leu Gly Ala Val Gly Leu Ala 
1               5                   10                  15      


Ala Val Asn Ser Met Pro Val Asp Asn Arg Asn His Asn Glu Gly Met 
            20                  25                  30          


Val Thr Arg Cys Ile Ile Glu Val Leu Ser Asn Ala Leu Ser Lys Ser 
        35                  40                  45              


Ser Ala Pro Pro Ile Thr Pro Glu Cys Arg Gln Val Leu Lys Thr Ser 
    50                  55                  60                  


Arg Lys Asp Val Lys Asp Lys Glu Thr Thr Glu Asn Glu Asn Thr Lys 
65                  70                  75                  80  


Phe Glu Val Arg Leu Leu Arg Asp Pro Ala Asp Ala Ser Glu Ala His 
                85                  90                  95      


Glu Ser Ser Ser Arg Gly Glu Ala Gly Ala Pro Gly Glu Glu Asp Ile 
            100                 105                 110         


Gln Gly Pro Thr Lys Ala Asp Thr Glu Lys Trp Ala Glu Gly Gly Gly 
        115                 120                 125             


His Ser Arg Glu Arg Ala Asp Glu Pro Gln Trp Ser Leu Tyr Pro Ser 
    130                 135                 140                 


Asp Ser Gln Val Ser Glu Glu Val Lys Thr Arg His Ser Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Glu Asp Glu Glu Glu Glu Glu Gly Glu Asn Tyr Gln Lys Gly 
                165                 170                 175     


Glu Arg Gly Glu Asp Ser Ser Glu Glu Lys His Leu Glu Glu Pro Gly 
            180                 185                 190         


Glu Thr Gln Asn Ala Phe Leu Asn Glu Arg Lys Gln Ala Ser Ala Ile 
        195                 200                 205             


Lys Lys Glu Glu Leu Val Ala Arg Ser Glu Thr His Ala Ala Gly His 
    210                 215                 220                 


Ser Gln Glu Lys Thr His Ser Arg Glu Lys Ser Ser Gln Glu Ser Gly 
225                 230                 235                 240 


Glu Glu Thr Gly Ser Gln Glu Asn His Pro Gln Glu Ser Lys Gly Gln 
                245                 250                 255     


Pro Arg Ser Gln Glu Glu Ser Glu Glu Gly Glu Glu Asp Ala Thr Ser 
            260                 265                 270         


Glu Val Asp Lys Arg Arg Thr Arg Pro Arg His His His Gly Arg Ser 
        275                 280                 285             


Arg Pro Asp Arg Ser Ser Gln Gly Gly Ser Leu Pro Ser Glu Glu Lys 
    290                 295                 300                 


Gly His Pro Gln Glu Glu Ser Glu Glu Ser Asn Val Ser Met Ala Ser 
305                 310                 315                 320 


Leu Gly Glu Lys Arg Asp His His Ser Thr His Tyr Arg Ala Ser Glu 
                325                 330                 335     


Glu Glu Pro Glu Tyr Gly Glu Glu Ile Lys Gly Tyr Pro Gly Val Gln 
            340                 345                 350         


Ala Pro Glu Asp Leu Glu Trp Glu Arg Tyr Arg Gly Arg Gly Ser Glu 
        355                 360                 365             


Glu Tyr Arg Ala Pro Arg Pro Gln Ser Glu Glu Ser Trp Asp Glu Glu 
    370                 375                 380                 


Asp Lys Arg Asn Tyr Pro Ser Leu Glu Leu Asp Lys Met Ala His Gly 
385                 390                 395                 400 


Tyr Gly Glu Glu Ser Glu Glu Glu Arg Gly Leu Glu Pro Gly Lys Gly 
                405                 410                 415     


Arg His His Arg Gly Arg Gly Gly Glu Pro Arg Ala Tyr Phe Met Ser 
            420                 425                 430         


Asp Thr Arg Glu Glu Lys Arg Phe Leu Gly Glu Gly His His Arg Val 
        435                 440                 445             


Gln Glu Asn Gln Met Asp Lys Ala Arg Arg His Pro Gln Gly Ala Trp 
    450                 455                 460                 


Lys Glu Leu Asp Arg Asn Tyr Leu Asn Tyr Gly Glu Glu Gly Ala Pro 
465                 470                 475                 480 


Gly Lys Trp Gln Gln Gln Gly Asp Leu Gln Asp Thr Lys Glu Asn Arg 
                485                 490                 495     


Glu Glu Ala Arg Phe Gln Asp Lys Gln Tyr Ser Ser His His Thr Ala 
            500                 505                 510         


Glu Lys Arg Lys Arg Leu Gly Glu Leu Phe Asn Pro Tyr Tyr Asp Pro 
        515                 520                 525             


Leu Gln Trp Lys Ser Ser His Phe Glu Arg Arg Asp Asn Met Asn Asp 
    530                 535                 540                 


Asn Phe Leu Glu Gly Glu Glu Glu Asn Glu Leu Thr Leu Asn Glu Lys 
545                 550                 555                 560 


Asn Phe Phe Pro Glu Tyr Asn Tyr Asp Trp Trp Glu Lys Lys Pro Phe 
                565                 570                 575     


Ser Glu Asp Val Asn Trp Gly Tyr Glu Lys Arg Asn Leu Ala Arg Val 
            580                 585                 590         


Pro Lys Leu Asp Leu Lys Arg Gln Tyr Asp Arg Val Ala Gln Leu Asp 
        595                 600                 605             


Gln Leu Leu His Tyr Arg Lys Lys Ser Ala Glu Phe Pro Asp Phe Tyr 
    610                 615                 620                 


Asp Ser Glu Glu Pro Val Ser Thr His Gln Glu Ala Glu Asn Glu Lys 
625                 630                 635                 640 


Asp Arg Ala Asp Gln Thr Val Leu Thr Glu Asp Glu Lys Lys Glu Leu 
                645                 650                 655     


Glu Asn Leu Ala Ala Met Asp Leu Glu Leu Gln Lys Ile Ala Glu Lys 
            660                 665                 670         


Phe Ser Gln Arg Gly 
        675         


<210>  34
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Thr Arg Asp Asp Val Pro Glu Ala Lys Val Leu Val Pro Val 
1               5                   10                  15      


Ala Val Tyr Cys Gly Ser Ile Pro Arg Thr Ser Ala Gly Pro Arg Val 
            20                  25                  30          


Leu Pro Pro Gly Ser Ile Asn Ser Ser Leu Pro His Gly Glu Gly Ser 
        35                  40                  45              


Leu Gln Pro Glu Pro Arg Ala Leu Leu Asn Asn Glu Glu Pro Ser Gln 
    50                  55                  60                  


Leu Leu Arg Gly Leu Gly Gln Leu Gly Gly Leu Lys Leu Asp Thr Pro 
65                  70                  75                  80  


Ser Lys Gly Trp Gln Ala Arg Asn Gly His Pro Arg Asn Leu Arg Ala 
                85                  90                  95      


Leu Ser Leu Gly Asp Gln Pro Leu Val Leu Leu Pro Ser Pro Glu Ser 
            100                 105                 110         


Glu Ala Asn Ser Val Ala Arg Asp Thr Ile Gln Ile Lys Asp Lys Leu 
        115                 120                 125             


Lys Lys Arg Arg Leu Ser Glu Gly Leu Ala Ala Ser Ser Arg Ala Ser 
    130                 135                 140                 


Leu Asp Pro Gly Gly Gly Pro Gln Gly Val Pro Leu His Ser Thr Ile 
145                 150                 155                 160 


Pro Arg Ala Thr Ser Gln Arg Leu Leu Arg Val Pro Arg Pro Met Pro 
                165                 170                 175     


Leu Ile Gln Ser Ile Pro Thr Thr Pro Glu Ala Ser Gly Val Lys Glu 
            180                 185                 190         


Lys Gly Leu Asp Leu Pro Gly Ser Ile Pro Gly Pro His Glu Leu Arg 
        195                 200                 205             


Pro Gly Ala Gln Glu Ala Gln Ile Ser Trp Gln Tyr Leu His Cys Asn 
    210                 215                 220                 


Asp Glu Lys Met Gln Lys Ser Leu Gly Ala Ile Val Ile Pro Pro Ile 
225                 230                 235                 240 


Pro Lys Ala Arg Thr Val Ala Ala Thr Pro Ser Arg Val Pro Gly Ser 
                245                 250                 255     


Leu Pro Ser Pro Leu Pro Pro Gly Gln Gly Val Leu Thr Gly Leu Arg 
            260                 265                 270         


Ala Pro Arg Thr Arg Leu Ala Arg Gly Ser Gly Pro Arg Glu Lys Thr 
        275                 280                 285             


Pro Ala Ser Leu Glu Pro Lys Pro Leu Ala Ser Pro Ile Arg Asp Arg 
    290                 295                 300                 


Pro Ala Ala Ala Lys Lys Pro Ala Leu Pro Phe Ser Gln Ser Ala Pro 
305                 310                 315                 320 


Thr Leu Thr Ala Phe Ser Phe Asp Cys Ala Arg Glu Ala Cys Pro Pro 
                325                 330                 335     


Leu Lys Glu Glu Asp Gln Lys Glu Ile Gly Thr Lys Ile Gln Val Thr 
            340                 345                 350         


Ile Ser Lys Ser Ala Arg Glu Lys Met Gln Leu Lys Gln Met Lys Glu 
        355                 360                 365             


Met Glu Leu Leu Arg Arg Leu Glu Glu Pro Arg Thr Gly Gln Glu Leu 
    370                 375                 380                 


Thr Ser Gln Cys Leu Gly Ser Gln Arg Ala Phe Met Lys Glu Gly Leu 
385                 390                 395                 400 


Leu Pro Leu Arg Gly Ser Gly Thr Leu Ser Val Pro Thr Arg Leu Ser 
                405                 410                 415     


Gly Pro Cys Arg Asn Asp Val Ser Ile Ile Leu Arg Lys Trp Ala Ser 
            420                 425                 430         


Arg Ala Ser Leu Pro Ser Ile Pro Ile Ser Arg Gln Glu Pro Arg Phe 
        435                 440                 445             


Ala Arg His Ala Ser Ala Asn Ser Leu Pro Ala Val Leu Thr Leu Gly 
    450                 455                 460                 


Ser Pro Glu Trp Glu Glu Glu Glu Glu Met Asp Leu Arg Ala Cys Lys 
465                 470                 475                 480 


Glu Leu Arg Pro Phe Ser Asn Pro Glu Leu Gly Leu Arg Asp Ala Leu 
                485                 490                 495     


Gln Cys Leu Asn Ser Ser Asp Trp Gln Met Lys Glu Lys Gly Leu Val 
            500                 505                 510         


Ser Ile Gln Arg Leu Ala Ala Cys His Ser Glu Val Leu Thr Gly Lys 
        515                 520                 525             


Leu His Asp Val Cys Leu Val Val Thr Gly Glu Val Thr Asn Leu Arg 
    530                 535                 540                 


Ser Lys Val Ser His Leu Ala Ile Ser Thr Leu Gly Asp Leu Phe Gln 
545                 550                 555                 560 


Ala Leu Lys Lys Asn Met Asp Gln Glu Ala Glu Glu Ile Ala Arg Cys 
                565                 570                 575     


Leu Leu Gln Lys Met Ala Asp Thr Asn Glu Phe Ile Gln Arg Ala Ala 
            580                 585                 590         


Gly Gln Ser Leu Arg Ala Met Val Glu Asn Val Thr Leu Ala Arg Ser 
        595                 600                 605             


Leu Val Val Leu Thr Ser Ala Gly Val Tyr His Arg Asn Pro Leu Ile 
    610                 615                 620                 


Arg Lys Tyr Ala Ala Glu His Leu Ser Ala Val Leu Glu Gln Ile Gly 
625                 630                 635                 640 


Ala Glu Lys Leu Leu Ser Gly Thr Arg Asp Ser Thr Asp Met Leu Val 
                645                 650                 655     


His Asn Leu Val Arg Leu Ala Gln Asp Ser Asn Gln Asp Thr Arg Phe 
            660                 665                 670         


Tyr Gly Arg Lys Met Val Asn Ile Leu Met Ala Asn Thr Lys Phe Asp 
        675                 680                 685             


Ala Phe Leu Lys Gln Ser Leu Pro Ser Tyr Asp Leu Gln Lys Val Met 
    690                 695                 700                 


Ala Ala Ile Lys Gln Gln Gly Ile Glu Asp Asn Asp Glu Leu Pro Ser 
705                 710                 715                 720 


Ala Lys Gly Arg Lys Val Leu Arg Ser Leu Val Val Cys Glu Asn Gly 
                725                 730                 735     


Leu Pro Ile Lys Glu Gly Leu Ser Cys Asn Gly Pro Arg Leu Val Gly 
            740                 745                 750         


Leu Arg Ser Thr Leu Gln Gly Arg Gly Glu Met Val Glu Gln Leu Arg 
        755                 760                 765             


Glu Leu Thr Arg Leu Leu Glu Ala Lys Asp Phe Arg Ser Arg Met Glu 
    770                 775                 780                 


Gly Val Gly Gln Leu Leu Glu Leu Cys Lys Ala Lys Thr Glu Leu Val 
785                 790                 795                 800 


Thr Ala His Leu Val Gln Val Phe Asp Ala Phe Thr Pro Arg Leu Gln 
                805                 810                 815     


Asp Ser Asn Lys Lys Val Asn Gln Trp Ala Leu Glu Ser Phe Ala Lys 
            820                 825                 830         


Met Ile Pro Leu Leu Arg Glu Ser Leu His Pro Met Leu Leu Ser Ile 
        835                 840                 845             


Ile Ile Thr Val Ala Asp Asn Leu Asn Ser Lys Asn Ser Gly Ile Tyr 
    850                 855                 860                 


Ala Ala Ala Val Ala Val Leu Asp Ala Met Val Glu Ser Leu Asp Asn 
865                 870                 875                 880 


Leu Cys Leu Leu Pro Ala Leu Ala Gly Arg Val Arg Phe Leu Ser Gly 
                885                 890                 895     


Arg Ala Val Leu Asp Val Thr Asp Arg Leu Ala Val Leu Val Ala Ser 
            900                 905                 910         


Val Tyr Pro Arg Lys Pro Gln Ala Val Glu Arg His Val Leu Pro Ile 
        915                 920                 925             


Leu Trp His Phe Leu Asn Thr Ala Thr Arg Asn Gly Thr Leu Pro Gly 
    930                 935                 940                 


Pro Ser Gly Asn Ile Arg Gly Val Val Cys Arg Leu Ser Arg Ser Leu 
945                 950                 955                 960 


Gln Glu His Met Gly Ser Arg Leu Leu Asp Phe Ala Ala Ser Gln Pro 
                965                 970                 975     


Lys His Val Leu Lys Thr Leu Gln Glu Leu Leu Asp Ser Glu Ser Leu 
            980                 985                 990         


Gly Gly Ser Arg Lys Ala Thr Asp  Arg Gly Val Ala Pro  Asp Ser Lys 
        995                 1000                 1005             


Thr Thr  Gly Ser Ser Tyr Pro  Phe Gln Leu Asp 
    1010                 1015                 


<210>  35
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
    290                 295                 300                 


Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
305                 310                 315                 320 


Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                325                 330                 335     


Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
            340                 345                 350         


Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
        355                 360                 365             


Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
    370                 375                 380                 


Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
385                 390                 395                 400 


Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                405                 410                 415     


His 
    


<210>  36
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Val Val Gly Ile Lys 
    290                 295             


<210>  37
<211>  1303
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Pro Gly Pro Arg Gly Ala Ala Gly Gly Leu Ala Pro Glu Met Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Gly Leu Leu Ala Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gly Leu Gly Gly Arg Val Glu Gly Gly Pro Ala Gly Glu 
        35                  40                  45              


Arg Gly Ala Gly Gly Gly Gly Ala Leu Ala Arg Glu Arg Phe Lys Val 
    50                  55                  60                  


Val Phe Ala Pro Val Ile Cys Lys Arg Thr Cys Leu Lys Gly Gln Cys 
65                  70                  75                  80  


Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn 
                85                  90                  95      


Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Val Val Val 
            100                 105                 110         


Cys Pro Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asn Gln 
        115                 120                 125             


Cys Leu Cys Pro Pro Asp Phe Thr Gly Arg Phe Cys Gln Val Pro Ala 
    130                 135                 140                 


Gly Gly Ala Gly Gly Gly Thr Gly Gly Ser Gly Pro Gly Leu Ser Arg 
145                 150                 155                 160 


Thr Gly Ala Leu Ser Thr Gly Ala Leu Pro Pro Leu Ala Pro Glu Gly 
                165                 170                 175     


Asp Ser Val Ala Ser Lys His Ala Ile Tyr Ala Val Gln Val Ile Ala 
            180                 185                 190         


Asp Pro Pro Gly Pro Gly Glu Gly Pro Pro Ala Gln His Ala Ala Phe 
        195                 200                 205             


Leu Val Pro Leu Gly Pro Gly Gln Ile Ser Ala Glu Val Gln Ala Pro 
    210                 215                 220                 


Pro Pro Val Val Asn Val Arg Val His His Pro Pro Glu Ala Ser Val 
225                 230                 235                 240 


Gln Val His Arg Ile Glu Ser Ser Asn Ala Glu Ser Ala Ala Pro Ser 
                245                 250                 255     


Gln His Leu Leu Pro His Pro Lys Pro Ser His Pro Arg Pro Pro Thr 
            260                 265                 270         


Gln Lys Pro Leu Gly Arg Cys Phe Gln Asp Thr Leu Pro Lys Gln Pro 
        275                 280                 285             


Cys Gly Ser Asn Pro Leu Pro Gly Leu Thr Lys Gln Glu Asp Cys Cys 
    290                 295                 300                 


Gly Ser Ile Gly Thr Ala Trp Gly Gln Ser Lys Cys His Lys Cys Pro 
305                 310                 315                 320 


Gln Leu Gln Tyr Thr Gly Val Gln Lys Pro Gly Pro Val Arg Gly Glu 
                325                 330                 335     


Val Gly Ala Asp Cys Pro Gln Gly Tyr Lys Arg Leu Asn Ser Thr His 
            340                 345                 350         


Cys Gln Asp Ile Asn Glu Cys Ala Met Pro Gly Val Cys Arg His Gly 
        355                 360                 365             


Asp Cys Leu Asn Asn Pro Gly Ser Tyr Arg Cys Val Cys Pro Pro Gly 
    370                 375                 380                 


His Ser Leu Gly Pro Ser Arg Thr Gln Cys Ile Ala Asp Lys Pro Glu 
385                 390                 395                 400 


Glu Lys Ser Leu Cys Phe Arg Leu Val Ser Pro Glu His Gln Cys Gln 
                405                 410                 415     


His Pro Leu Thr Thr Arg Leu Thr Arg Gln Leu Cys Cys Cys Ser Val 
            420                 425                 430         


Gly Lys Ala Trp Gly Ala Arg Cys Gln Arg Cys Pro Thr Asp Gly Thr 
        435                 440                 445             


Ala Ala Phe Lys Glu Ile Cys Pro Ala Gly Lys Gly Tyr His Ile Leu 
    450                 455                 460                 


Thr Ser His Gln Thr Leu Thr Ile Gln Gly Glu Ser Asp Phe Ser Leu 
465                 470                 475                 480 


Phe Leu His Pro Asp Gly Pro Pro Lys Pro Gln Gln Leu Pro Glu Ser 
                485                 490                 495     


Pro Ser Gln Ala Pro Pro Pro Glu Asp Thr Glu Glu Glu Arg Gly Val 
            500                 505                 510         


Thr Thr Asp Ser Pro Val Ser Glu Glu Arg Ser Val Gln Gln Ser His 
        515                 520                 525             


Pro Thr Ala Thr Thr Thr Pro Ala Arg Pro Tyr Pro Glu Leu Ile Ser 
    530                 535                 540                 


Arg Pro Ser Pro Pro Thr Met Arg Trp Phe Leu Pro Asp Leu Pro Pro 
545                 550                 555                 560 


Ser Arg Ser Ala Val Glu Ile Ala Pro Thr Gln Val Thr Glu Thr Asp 
                565                 570                 575     


Glu Cys Arg Leu Asn Gln Asn Ile Cys Gly His Gly Glu Cys Val Pro 
            580                 585                 590         


Gly Pro Pro Asp Tyr Ser Cys His Cys Asn Pro Gly Tyr Arg Ser His 
        595                 600                 605             


Pro Gln His Arg Tyr Cys Val Asp Val Asn Glu Cys Glu Ala Glu Pro 
    610                 615                 620                 


Cys Gly Pro Gly Arg Gly Ile Cys Met Asn Thr Gly Gly Ser Tyr Asn 
625                 630                 635                 640 


Cys His Cys Asn Arg Gly Tyr Arg Leu His Val Gly Ala Gly Gly Arg 
                645                 650                 655     


Ser Cys Val Asp Leu Asn Glu Cys Ala Lys Pro His Leu Cys Gly Asp 
            660                 665                 670         


Gly Gly Phe Cys Ile Asn Phe Pro Gly His Tyr Lys Cys Asn Cys Tyr 
        675                 680                 685             


Pro Gly Tyr Arg Leu Lys Ala Ser Arg Pro Pro Val Cys Glu Asp Ile 
    690                 695                 700                 


Asp Glu Cys Arg Asp Pro Ser Ser Cys Pro Asp Gly Lys Cys Glu Asn 
705                 710                 715                 720 


Lys Pro Gly Ser Phe Lys Cys Ile Ala Cys Gln Pro Gly Tyr Arg Ser 
                725                 730                 735     


Gln Gly Gly Gly Ala Cys Arg Asp Val Asn Glu Cys Ala Glu Gly Ser 
            740                 745                 750         


Pro Cys Ser Pro Gly Trp Cys Glu Asn Leu Pro Gly Ser Phe Arg Cys 
        755                 760                 765             


Thr Cys Ala Gln Gly Tyr Ala Pro Ala Pro Asp Gly Arg Ser Cys Leu 
    770                 775                 780                 


Asp Val Asp Glu Cys Glu Ala Gly Asp Val Cys Asp Asn Gly Ile Cys 
785                 790                 795                 800 


Ser Asn Thr Pro Gly Ser Phe Gln Cys Gln Cys Leu Ser Gly Tyr His 
                805                 810                 815     


Leu Ser Arg Asp Arg Ser His Cys Glu Asp Ile Asp Glu Cys Asp Phe 
            820                 825                 830         


Pro Ala Ala Cys Ile Gly Gly Asp Cys Ile Asn Thr Asn Gly Ser Tyr 
        835                 840                 845             


Arg Cys Leu Cys Pro Gln Gly His Arg Leu Val Gly Gly Arg Lys Cys 
    850                 855                 860                 


Gln Asp Ile Asp Glu Cys Ser Gln Asp Pro Ser Leu Cys Leu Pro His 
865                 870                 875                 880 


Gly Ala Cys Lys Asn Leu Gln Gly Ser Tyr Val Cys Val Cys Asp Glu 
                885                 890                 895     


Gly Phe Thr Pro Thr Gln Asp Gln His Gly Cys Glu Glu Val Glu Gln 
            900                 905                 910         


Pro His His Lys Lys Glu Cys Tyr Leu Asn Phe Asp Asp Thr Val Phe 
        915                 920                 925             


Cys Asp Ser Val Leu Ala Thr Asn Val Thr Gln Gln Glu Cys Cys Cys 
    930                 935                 940                 


Ser Leu Gly Ala Gly Trp Gly Asp His Cys Glu Ile Tyr Pro Cys Pro 
945                 950                 955                 960 


Val Tyr Ser Ser Ala Glu Phe His Ser Leu Cys Pro Asp Gly Lys Gly 
                965                 970                 975     


Tyr Thr Gln Asp Asn Asn Ile Val Asn Tyr Gly Ile Pro Ala His Arg 
            980                 985                 990         


Asp Ile Asp Glu Cys Met Leu Phe  Gly Ser Glu Ile Cys  Lys Glu Gly 
        995                 1000                 1005             


Lys Cys  Val Asn Thr Gln Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1010                 1015                 1020             


Gly Phe  Tyr Tyr Asp Gly Asn  Leu Leu Glu Cys Val  Asp Val Asp 
    1025                 1030                 1035             


Glu Cys  Leu Asp Glu Ser Asn  Cys Arg Asn Gly Val  Cys Glu Asn 
    1040                 1045                 1050             


Thr Arg  Gly Gly Tyr Arg Cys  Ala Cys Thr Pro Pro  Ala Glu Tyr 
    1055                 1060                 1065             


Ser Pro  Ala Gln Arg Gln Cys  Leu Ser Pro Glu Glu  Met Asp Val 
    1070                 1075                 1080             


Asp Glu  Cys Gln Asp Pro Ala  Ala Cys Arg Pro Gly  Arg Cys Val 
    1085                 1090                 1095             


Asn Leu  Pro Gly Ser Tyr Arg  Cys Glu Cys Arg Pro  Pro Trp Val 
    1100                 1105                 1110             


Pro Gly  Pro Ser Gly Arg Asp  Cys Gln Leu Pro Glu  Ser Pro Ala 
    1115                 1120                 1125             


Glu Arg  Ala Pro Glu Arg Arg  Asp Val Cys Trp Ser  Gln Arg Gly 
    1130                 1135                 1140             


Glu Asp  Gly Met Cys Ala Gly  Pro Leu Ala Gly Pro  Ala Leu Thr 
    1145                 1150                 1155             


Phe Asp  Asp Cys Cys Cys Arg  Gln Gly Arg Gly Trp  Gly Ala Gln 
    1160                 1165                 1170             


Cys Arg  Pro Cys Pro Pro Arg  Gly Ala Gly Ser His  Cys Pro Thr 
    1175                 1180                 1185             


Ser Gln  Ser Glu Ser Asn Ser  Phe Trp Asp Thr Ser  Pro Leu Leu 
    1190                 1195                 1200             


Leu Gly  Lys Pro Pro Arg Asp  Glu Asp Ser Ser Glu  Glu Asp Ser 
    1205                 1210                 1215             


Asp Glu  Cys Arg Cys Val Ser  Gly Arg Cys Val Pro  Arg Pro Gly 
    1220                 1225                 1230             


Gly Ala  Val Cys Glu Cys Pro  Gly Gly Phe Gln Leu  Asp Ala Ser 
    1235                 1240                 1245             


Arg Ala  Arg Cys Val Asp Ile  Asp Glu Cys Arg Glu  Leu Asn Gln 
    1250                 1255                 1260             


Arg Gly  Leu Leu Cys Lys Ser  Glu Arg Cys Val Asn  Thr Ser Gly 
    1265                 1270                 1275             


Ser Phe  Arg Cys Val Cys Lys  Ala Gly Phe Ala Arg  Ser Arg Pro 
    1280                 1285                 1290             


His Gly  Ala Cys Val Pro Gln  Arg Arg Arg 
    1295                 1300             


<210>  38
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Ile Leu Val Pro Leu Leu Gln Leu Leu Val Leu Leu Leu Thr 
1               5                   10                  15      


Leu Pro Leu His Leu Met Ala Leu Leu Gly Cys Trp Gln Pro Leu Cys 
            20                  25                  30          


Lys Ser Tyr Phe Pro Tyr Leu Met Ala Val Leu Thr Pro Lys Ser Asn 
        35                  40                  45              


Arg Lys Met Glu Ser Lys Lys Arg Glu Leu Phe Ser Gln Ile Lys Gly 
    50                  55                  60                  


Leu Thr Gly Ala Ser Gly Lys Val Ala Leu Leu Glu Leu Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Gln Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Leu Asp Pro Asn Pro His Phe Glu Lys Phe Leu Thr Lys Ser Met Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Tyr Glu Arg Phe Val Val Ala Pro Gly Glu 
        115                 120                 125             


Asp Met Arg Gln Leu Ala Asp Gly Ser Met Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Gln Ser Pro Arg Lys Val Leu Gln Glu Val 
145                 150                 155                 160 


Arg Arg Val Leu Arg Pro Gly Gly Val Leu Phe Phe Trp Glu His Val 
                165                 170                 175     


Ala Glu Pro Tyr Gly Ser Trp Ala Phe Met Trp Gln Gln Val Phe Glu 
            180                 185                 190         


Pro Thr Trp Lys His Ile Gly Asp Gly Cys Cys Leu Thr Arg Glu Thr 
        195                 200                 205             


Trp Lys Asp Leu Glu Asn Ala Gln Phe Ser Glu Ile Gln Met Glu Arg 
    210                 215                 220                 


Gln Pro Pro Pro Leu Lys Trp Leu Pro Val Gly Pro His Ile Met Gly 
225                 230                 235                 240 


Lys Ala Val Lys 
                


<210>  39
<211>  1821
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Arg Pro Arg Thr Lys Ala Arg Ser Pro Gly Arg Ala Leu Arg Asn 
1               5                   10                  15      


Pro Trp Arg Gly Phe Leu Pro Leu Thr Leu Ala Leu Phe Val Gly Ala 
            20                  25                  30          


Gly His Ala Gln Arg Asp Pro Val Gly Arg Tyr Glu Pro Ala Gly Gly 
        35                  40                  45              


Asp Ala Asn Arg Leu Arg Arg Pro Gly Gly Ser Tyr Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Lys Val Tyr Ser Leu Phe Arg Glu Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Glu Arg Ala Gln Pro Gly Trp Gly Ser Pro Arg 
                85                  90                  95      


Arg Pro Thr Glu Ala Glu Ala Arg Arg Pro Ser Arg Ala Gln Gln Ser 
            100                 105                 110         


Arg Arg Val Gln Pro Pro Ala Gln Thr Arg Arg Ser Thr Pro Leu Gly 
        115                 120                 125             


Gln Gln Gln Pro Ala Pro Arg Thr Arg Ala Ala Pro Ala Leu Pro Arg 
    130                 135                 140                 


Leu Gly Thr Pro Gln Arg Ser Gly Ala Ala Pro Pro Thr Pro Pro Arg 
145                 150                 155                 160 


Gly Arg Leu Thr Gly Arg Asn Val Cys Gly Gly Gln Cys Cys Pro Gly 
                165                 170                 175     


Trp Thr Thr Ala Asn Ser Thr Asn His Cys Ile Lys Pro Val Cys Glu 
            180                 185                 190         


Pro Pro Cys Gln Asn Arg Gly Ser Cys Ser Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Arg Ser Gly Phe Arg Gly Ala Arg Cys Glu Glu Val Ile Pro Asp 
    210                 215                 220                 


Glu Glu Phe Asp Pro Gln Asn Ser Arg Leu Ala Pro Arg Arg Trp Ala 
225                 230                 235                 240 


Glu Arg Ser Pro Asn Leu Arg Arg Ser Ser Ala Ala Gly Glu Gly Thr 
                245                 250                 255     


Leu Ala Arg Ala Gln Pro Pro Ala Pro Gln Ser Pro Pro Ala Pro Gln 
            260                 265                 270         


Ser Pro Pro Ala Gly Thr Leu Ser Gly Leu Ser Gln Thr His Pro Ser 
        275                 280                 285             


Gln Gln His Val Gly Leu Ser Arg Thr Val Arg Leu His Pro Thr Ala 
    290                 295                 300                 


Thr Ala Ser Ser Gln Leu Ser Ser Asn Ala Leu Pro Pro Gly Pro Gly 
305                 310                 315                 320 


Leu Glu Gln Arg Asp Gly Thr Gln Gln Ala Val Pro Leu Glu His Pro 
                325                 330                 335     


Ser Ser Pro Trp Gly Leu Asn Leu Thr Glu Lys Ile Lys Lys Ile Lys 
            340                 345                 350         


Ile Val Phe Thr Pro Thr Ile Cys Lys Gln Thr Cys Ala Arg Gly His 
        355                 360                 365             


Cys Ala Asn Ser Cys Glu Arg Gly Asp Thr Thr Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Gly Gly His Gly His Asp Pro Lys Ser Gly Phe Arg Ile Tyr Phe Cys 
385                 390                 395                 400 


Gln Ile Pro Cys Leu Asn Gly Gly Arg Cys Ile Gly Arg Asp Glu Cys 
                405                 410                 415     


Trp Cys Pro Ala Asn Ser Thr Gly Lys Phe Cys His Leu Pro Ile Pro 
            420                 425                 430         


Gln Pro Asp Arg Glu Pro Pro Gly Arg Gly Ser Arg Pro Arg Ala Leu 
        435                 440                 445             


Leu Glu Ala Pro Leu Lys Gln Ser Thr Phe Thr Leu Pro Leu Ser Asn 
    450                 455                 460                 


Gln Leu Ala Ser Val Asn Pro Ser Leu Val Lys Val His Ile His His 
465                 470                 475                 480 


Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ala Gln Val Arg Gly 
                485                 490                 495     


Gly Val Glu Glu Ala Leu Val Glu Asn Ser Val Glu Thr Arg Pro Pro 
            500                 505                 510         


Pro Trp Leu Pro Ala Ser Pro Gly His Ser Leu Trp Asp Ser Asn Asn 
        515                 520                 525             


Ile Pro Ala Arg Ser Gly Glu Pro Pro Arg Pro Leu Pro Pro Ala Ala 
    530                 535                 540                 


Pro Arg Pro Arg Gly Leu Leu Gly Arg Cys Tyr Leu Asn Thr Val Asn 
545                 550                 555                 560 


Gly Gln Cys Ala Asn Pro Leu Leu Glu Leu Thr Thr Gln Glu Asp Cys 
                565                 570                 575     


Cys Gly Ser Val Gly Ala Phe Trp Gly Val Thr Leu Cys Ala Pro Cys 
            580                 585                 590         


Pro Pro Arg Pro Ala Ser Pro Val Ile Glu Asn Gly Gln Leu Glu Cys 
        595                 600                 605             


Pro Gln Gly Tyr Lys Arg Leu Asn Leu Thr His Cys Gln Asp Ile Asn 
    610                 615                 620                 


Glu Cys Leu Thr Leu Gly Leu Cys Lys Asp Ala Glu Cys Val Asn Thr 
625                 630                 635                 640 


Arg Gly Ser Tyr Leu Cys Thr Cys Arg Pro Gly Leu Met Leu Asp Pro 
                645                 650                 655     


Ser Arg Ser Arg Cys Val Ser Asp Lys Ala Ile Ser Met Leu Gln Gly 
            660                 665                 670         


Leu Cys Tyr Arg Ser Leu Gly Pro Gly Thr Cys Thr Leu Pro Leu Ala 
        675                 680                 685             


Gln Arg Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg Val Gly Lys Ala 
    690                 695                 700                 


Trp Gly Ser Glu Cys Glu Lys Cys Pro Leu Pro Gly Thr Glu Ala Phe 
705                 710                 715                 720 


Arg Glu Ile Cys Pro Ala Gly His Gly Tyr Thr Tyr Ala Ser Ser Asp 
                725                 730                 735     


Ile Arg Leu Ser Met Arg Lys Ala Glu Glu Glu Glu Leu Ala Arg Pro 
            740                 745                 750         


Pro Arg Glu Gln Gly Gln Arg Ser Ser Gly Ala Leu Pro Gly Pro Ala 
        755                 760                 765             


Glu Arg Gln Pro Leu Arg Val Val Thr Asp Thr Trp Leu Glu Ala Gly 
    770                 775                 780                 


Thr Ile Pro Asp Lys Gly Asp Ser Gln Ala Gly Gln Val Thr Thr Ser 
785                 790                 795                 800 


Val Thr His Ala Pro Ala Trp Val Thr Gly Asn Ala Thr Thr Pro Pro 
                805                 810                 815     


Met Pro Glu Gln Gly Ile Ala Glu Ile Gln Glu Glu Gln Val Thr Pro 
            820                 825                 830         


Ser Thr Asp Val Leu Val Thr Leu Ser Thr Pro Gly Ile Asp Arg Cys 
        835                 840                 845             


Ala Ala Gly Ala Thr Asn Val Cys Gly Pro Gly Thr Cys Val Asn Leu 
    850                 855                 860                 


Pro Asp Gly Tyr Arg Cys Val Cys Ser Pro Gly Tyr Gln Leu His Pro 
865                 870                 875                 880 


Ser Gln Ala Tyr Cys Thr Asp Asp Asn Glu Cys Leu Arg Asp Pro Cys 
                885                 890                 895     


Lys Gly Lys Gly Arg Cys Ile Asn Arg Val Gly Ser Tyr Ser Cys Phe 
            900                 905                 910         


Cys Tyr Pro Gly Tyr Thr Leu Ala Thr Ser Gly Ala Thr Gln Glu Cys 
        915                 920                 925             


Gln Asp Ile Asn Glu Cys Glu Gln Pro Gly Val Cys Ser Gly Gly Gln 
    930                 935                 940                 


Cys Thr Asn Thr Glu Gly Ser Tyr His Cys Glu Cys Asp Gln Gly Tyr 
945                 950                 955                 960 


Ile Met Val Arg Lys Gly His Cys Gln Asp Ile Asn Glu Cys Arg His 
                965                 970                 975     


Pro Gly Thr Cys Pro Asp Gly Arg Cys Val Asn Ser Pro Gly Ser Tyr 
            980                 985                 990         


Thr Cys Leu Ala Cys Glu Glu Gly  Tyr Arg Gly Gln Ser  Gly Ser Cys 
        995                 1000                 1005             


Val Asp  Val Asn Glu Cys Leu  Thr Pro Gly Val Cys  Ala His Gly 
    1010                 1015                 1020             


Lys Cys  Thr Asn Leu Glu Gly  Ser Phe Arg Cys Ser  Cys Glu Gln 
    1025                 1030                 1035             


Gly Tyr  Glu Val Thr Ser Asp  Glu Lys Gly Cys Gln  Asp Val Asp 
    1040                 1045                 1050             


Glu Cys  Ala Ser Arg Ala Ser  Cys Pro Thr Gly Leu  Cys Leu Asn 
    1055                 1060                 1065             


Thr Glu  Gly Ser Phe Ala Cys  Ser Ala Cys Glu Asn  Gly Tyr Trp 
    1070                 1075                 1080             


Val Asn  Glu Asp Gly Thr Ala  Cys Glu Asp Leu Asp  Glu Cys Ala 
    1085                 1090                 1095             


Phe Pro  Gly Val Cys Pro Ser  Gly Val Cys Thr Asn  Thr Ala Gly 
    1100                 1105                 1110             


Ser Phe  Ser Cys Lys Asp Cys  Asp Gly Gly Tyr Arg  Pro Ser Pro 
    1115                 1120                 1125             


Leu Gly  Asp Ser Cys Glu Asp  Val Asp Glu Cys Glu  Asp Pro Gln 
    1130                 1135                 1140             


Ser Ser  Cys Leu Gly Gly Glu  Cys Lys Asn Thr Val  Gly Ser Tyr 
    1145                 1150                 1155             


Gln Cys  Leu Cys Pro Gln Gly  Phe Gln Leu Ala Asn  Gly Thr Val 
    1160                 1165                 1170             


Cys Glu  Asp Val Asn Glu Cys  Met Gly Glu Glu His  Cys Ala Pro 
    1175                 1180                 1185             


His Gly  Glu Cys Leu Asn Ser  His Gly Ser Phe Phe  Cys Leu Cys 
    1190                 1195                 1200             


Ala Pro  Gly Phe Val Ser Ala  Glu Gly Gly Thr Ser  Cys Gln Asp 
    1205                 1210                 1215             


Val Asp  Glu Cys Ala Thr Thr  Asp Pro Cys Val Gly  Gly His Cys 
    1220                 1225                 1230             


Val Asn  Thr Glu Gly Ser Phe  Asn Cys Leu Cys Glu  Thr Gly Phe 
    1235                 1240                 1245             


Gln Pro  Ser Pro Glu Ser Gly  Glu Cys Val Asp Ile  Asp Glu Cys 
    1250                 1255                 1260             


Glu Asp  Tyr Gly Asp Pro Val  Cys Gly Thr Trp Lys  Cys Glu Asn 
    1265                 1270                 1275             


Ser Pro  Gly Ser Tyr Arg Cys  Val Leu Gly Cys Gln  Pro Gly Phe 
    1280                 1285                 1290             


His Met  Ala Pro Asn Gly Asp  Cys Ile Asp Ile Asp  Glu Cys Ala 
    1295                 1300                 1305             


Asn Asp  Thr Met Cys Gly Ser  His Gly Phe Cys Asp  Asn Thr Asp 
    1310                 1315                 1320             


Gly Ser  Phe Arg Cys Leu Cys  Asp Gln Gly Phe Glu  Ile Ser Pro 
    1325                 1330                 1335             


Ser Gly  Trp Asp Cys Val Asp  Val Asn Glu Cys Glu  Leu Met Leu 
    1340                 1345                 1350             


Ala Val  Cys Gly Ala Ala Leu  Cys Glu Asn Val Glu  Gly Ser Phe 
    1355                 1360                 1365             


Leu Cys  Leu Cys Ala Ser Asp  Leu Glu Glu Tyr Asp  Ala Gln Glu 
    1370                 1375                 1380             


Gly His  Cys Arg Pro Arg Gly  Ala Gly Gly Gln Ser  Met Ser Glu 
    1385                 1390                 1395             


Ala Pro  Thr Gly Asp His Ala  Pro Ala Pro Thr Arg  Met Asp Cys 
    1400                 1405                 1410             


Tyr Ser  Gly Gln Lys Gly His  Ala Pro Cys Ser Ser  Val Leu Gly 
    1415                 1420                 1425             


Arg Asn  Thr Thr Gln Ala Glu  Cys Cys Cys Thr Gln  Gly Ala Ser 
    1430                 1435                 1440             


Trp Gly  Asp Ala Cys Asp Leu  Cys Pro Ser Glu Asp  Ser Ala Glu 
    1445                 1450                 1455             


Phe Ser  Glu Ile Cys Pro Ser  Gly Lys Gly Tyr Ile  Pro Val Glu 
    1460                 1465                 1470             


Gly Ala  Trp Thr Phe Gly Gln  Thr Met Tyr Thr Asp  Ala Asp Glu 
    1475                 1480                 1485             


Cys Val  Ile Phe Gly Pro Gly  Leu Cys Pro Asn Gly  Arg Cys Leu 
    1490                 1495                 1500             


Asn Thr  Val Pro Gly Tyr Val  Cys Leu Cys Asn Pro  Gly Phe His 
    1505                 1510                 1515             


Tyr Asp  Ala Ser His Lys Lys  Cys Glu Asp His Asp  Glu Cys Gln 
    1520                 1525                 1530             


Asp Leu  Ala Cys Glu Asn Gly  Glu Cys Val Asn Thr  Glu Gly Ser 
    1535                 1540                 1545             


Phe His  Cys Phe Cys Ser Pro  Pro Leu Thr Leu Asp  Leu Ser Gln 
    1550                 1555                 1560             


Gln Arg  Cys Met Asn Ser Thr  Ser Ser Thr Glu Asp  Leu Pro Asp 
    1565                 1570                 1575             


His Asp  Ile His Met Asp Ile  Cys Trp Lys Lys Val  Thr Asn Asp 
    1580                 1585                 1590             


Val Cys  Ser Glu Pro Leu Arg  Gly His Arg Thr Thr  Tyr Thr Glu 
    1595                 1600                 1605             


Cys Cys  Cys Gln Asp Gly Glu  Ala Trp Ser Gln Gln  Cys Ala Leu 
    1610                 1615                 1620             


Cys Pro  Pro Arg Ser Ser Glu  Val Tyr Ala Gln Leu  Cys Asn Val 
    1625                 1630                 1635             


Ala Arg  Ile Glu Ala Glu Arg  Glu Ala Gly Val His  Phe Arg Pro 
    1640                 1645                 1650             


Gly Tyr  Glu Tyr Gly Pro Gly  Pro Asp Asp Leu His  Tyr Ser Ile 
    1655                 1660                 1665             


Tyr Gly  Pro Asp Gly Ala Pro  Phe Tyr Asn Tyr Leu  Gly Pro Glu 
    1670                 1675                 1680             


Asp Thr  Val Pro Glu Pro Ala  Phe Pro Asn Thr Ala  Gly His Ser 
    1685                 1690                 1695             


Ala Asp  Arg Thr Pro Ile Leu  Glu Ser Pro Leu Gln  Pro Ser Glu 
    1700                 1705                 1710             


Leu Gln  Pro His Tyr Val Ala  Ser His Pro Glu Pro  Pro Ala Gly 
    1715                 1720                 1725             


Phe Glu  Gly Leu Gln Ala Glu  Glu Cys Gly Ile Leu  Asn Gly Cys 
    1730                 1735                 1740             


Glu Asn  Gly Arg Cys Val Arg  Val Arg Glu Gly Tyr  Thr Cys Asp 
    1745                 1750                 1755             


Cys Phe  Glu Gly Phe Gln Leu  Asp Ala Ala His Met  Ala Cys Val 
    1760                 1765                 1770             


Asp Val  Asn Glu Cys Asp Asp  Leu Asn Gly Pro Ala  Val Leu Cys 
    1775                 1780                 1785             


Val His  Gly Tyr Cys Glu Asn  Thr Glu Gly Ser Tyr  Arg Cys His 
    1790                 1795                 1800             


Cys Ser  Pro Gly Tyr Val Ala  Glu Ala Gly Pro Pro  His Cys Thr 
    1805                 1810                 1815             


Ala Lys  Glu 
    1820     


<210>  40
<211>  1010
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Gln Leu Arg Leu Leu Pro Ser Arg Leu Gly Val Gln Ala Ala 
1               5                   10                  15      


Arg Leu Leu Ala Ala His Asp Val Pro Val Phe Gly Trp Arg Ser Arg 
            20                  25                  30          


Ser Ser Gly Pro Pro Ala Thr Phe Pro Ser Ser Lys Gly Gly Gly Gly 
        35                  40                  45              


Ser Ser Tyr Met Glu Glu Met Tyr Phe Ala Trp Leu Glu Asn Pro Gln 
    50                  55                  60                  


Ser Val His Lys Ser Trp Asp Ser Phe Phe Arg Glu Ala Ser Glu Glu 
65                  70                  75                  80  


Ala Phe Ser Gly Ser Ala Gln Pro Arg Pro Pro Ser Val Val His Glu 
                85                  90                  95      


Ser Arg Ser Ala Val Ser Ser Arg Thr Lys Thr Ser Lys Leu Val Glu 
            100                 105                 110         


Asp His Leu Ala Val Gln Ser Leu Ile Arg Ala Tyr Gln Ile Arg Gly 
        115                 120                 125             


His His Val Ala Gln Leu Asp Pro Leu Gly Ile Leu Asp Ala Asp Leu 
    130                 135                 140                 


Asp Ser Phe Val Pro Ser Asp Leu Ile Thr Thr Ile Asp Lys Leu Ala 
145                 150                 155                 160 


Phe Tyr Asp Leu Gln Glu Ala Asp Leu Asp Lys Glu Phe Gln Leu Pro 
                165                 170                 175     


Thr Thr Thr Phe Ile Gly Gly Ser Glu Asn Thr Leu Ser Leu Arg Glu 
            180                 185                 190         


Ile Ile Arg Arg Leu Glu Asn Thr Tyr Cys Gln His Ile Gly Leu Glu 
        195                 200                 205             


Phe Met Phe Ile Asn Asp Val Glu Gln Cys Gln Trp Ile Arg Gln Lys 
    210                 215                 220                 


Phe Glu Thr Pro Gly Val Met Gln Phe Ser Ser Glu Glu Lys Arg Thr 
225                 230                 235                 240 


Leu Leu Ala Arg Leu Val Arg Ser Met Arg Phe Glu Asp Phe Leu Ala 
                245                 250                 255     


Arg Lys Trp Ser Ser Glu Lys Arg Phe Gly Leu Glu Gly Cys Glu Val 
            260                 265                 270         


Met Ile Pro Ala Leu Lys Thr Ile Ile Asp Lys Ser Ser Glu Met Gly 
        275                 280                 285             


Ile Glu Asn Val Ile Leu Gly Met Pro His Arg Gly Arg Leu Asn Val 
    290                 295                 300                 


Leu Ala Asn Val Ile Arg Lys Asp Leu Glu Gln Ile Phe Cys Gln Phe 
305                 310                 315                 320 


Asp Pro Lys Leu Glu Ala Ala Asp Glu Gly Ser Gly Asp Val Lys Tyr 
                325                 330                 335     


His Leu Gly Met Tyr His Glu Arg Ile Asn Arg Val Thr Asn Arg Asn 
            340                 345                 350         


Ile Thr Leu Ser Leu Val Ala Asn Pro Ser His Leu Glu Ala Val Asp 
        355                 360                 365             


Pro Val Val Gln Gly Lys Thr Lys Ala Glu Gln Phe Tyr Arg Gly Asp 
    370                 375                 380                 


Ala Gln Gly Lys Lys Val Met Ser Ile Leu Val His Gly Asp Ala Ala 
385                 390                 395                 400 


Phe Ala Gly Gln Gly Val Val Tyr Glu Thr Phe His Leu Ser Asp Leu 
                405                 410                 415     


Pro Ser Tyr Thr Thr Asn Gly Thr Val His Val Val Val Asn Asn Gln 
            420                 425                 430         


Ile Gly Phe Thr Thr Asp Pro Arg Met Ala Arg Ser Ser Pro Tyr Pro 
        435                 440                 445             


Thr Asp Val Ala Arg Val Val Asn Ala Pro Ile Phe His Val Asn Ala 
    450                 455                 460                 


Asp Asp Pro Glu Ala Val Ile Tyr Val Cys Ser Val Ala Ala Glu Trp 
465                 470                 475                 480 


Arg Asn Thr Phe Asn Lys Asp Val Val Val Asp Leu Val Cys Tyr Arg 
                485                 490                 495     


Arg Arg Gly His Asn Glu Met Asp Glu Pro Met Phe Thr Gln Pro Leu 
            500                 505                 510         


Met Tyr Lys Gln Ile His Arg Gln Val Pro Val Leu Lys Lys Tyr Ala 
        515                 520                 525             


Asp Lys Leu Ile Ala Glu Gly Thr Val Thr Leu Gln Glu Phe Glu Glu 
    530                 535                 540                 


Glu Ile Ala Lys Tyr Asp Arg Ile Cys Glu Glu Ala Tyr Gly Arg Ser 
545                 550                 555                 560 


Lys Asp Lys Lys Ile Leu His Ile Lys His Trp Leu Asp Ser Pro Trp 
                565                 570                 575     


Pro Gly Phe Phe Asn Val Asp Gly Glu Pro Lys Ser Met Thr Cys Pro 
            580                 585                 590         


Ala Thr Gly Ile Pro Glu Asp Met Leu Thr His Ile Gly Ser Val Ala 
        595                 600                 605             


Ser Ser Val Pro Leu Glu Asp Phe Lys Ile His Thr Gly Leu Ser Arg 
    610                 615                 620                 


Ile Leu Arg Gly Arg Ala Asp Met Thr Lys Asn Arg Thr Val Asp Trp 
625                 630                 635                 640 


Ala Leu Ala Glu Tyr Met Ala Phe Gly Ser Leu Leu Lys Glu Gly Ile 
                645                 650                 655     


His Val Arg Leu Ser Gly Gln Asp Val Glu Arg Gly Thr Phe Ser His 
            660                 665                 670         


Arg His His Val Leu His Asp Gln Glu Val Asp Arg Arg Thr Cys Val 
        675                 680                 685             


Pro Met Asn His Leu Trp Pro Asp Gln Ala Pro Tyr Thr Val Cys Asn 
    690                 695                 700                 


Ser Ser Leu Ser Glu Tyr Gly Val Leu Gly Phe Glu Leu Gly Tyr Ala 
705                 710                 715                 720 


Met Ala Ser Pro Asn Ala Leu Val Leu Trp Glu Ala Gln Phe Gly Asp 
                725                 730                 735     


Phe His Asn Thr Ala Gln Cys Ile Ile Asp Gln Phe Ile Ser Thr Gly 
            740                 745                 750         


Gln Ala Lys Trp Val Arg His Asn Gly Ile Val Leu Leu Leu Pro His 
        755                 760                 765             


Gly Met Glu Gly Met Gly Pro Glu His Ser Ser Ala Arg Pro Glu Arg 
    770                 775                 780                 


Phe Leu Gln Met Ser Asn Asp Asp Ser Asp Ala Tyr Pro Ala Phe Thr 
785                 790                 795                 800 


Lys Asp Phe Glu Val Ser Gln Leu Tyr Asp Cys Asn Trp Ile Val Val 
                805                 810                 815     


Asn Cys Ser Thr Pro Ala Asn Tyr Phe His Val Leu Arg Arg Gln Ile 
            820                 825                 830         


Leu Leu Pro Phe Arg Lys Pro Leu Ile Ile Phe Thr Pro Lys Ser Leu 
        835                 840                 845             


Leu Arg His Pro Glu Ala Lys Ser Ser Phe Asp Gln Met Val Ser Gly 
    850                 855                 860                 


Thr Ser Phe Gln Arg Val Ile Pro Glu Asp Gly Ala Ala Ala Arg Ala 
865                 870                 875                 880 


Pro Glu Gln Val Gln Arg Leu Ile Phe Cys Thr Gly Lys Val Tyr Tyr 
                885                 890                 895     


Asp Leu Val Lys Glu Arg Ser Ser Gln Asp Leu Glu Glu Lys Val Ala 
            900                 905                 910         


Ile Thr Arg Leu Glu Gln Ile Ser Pro Phe Pro Phe Asp Leu Ile Lys 
        915                 920                 925             


Gln Glu Ala Glu Lys Tyr Pro Gly Ala Glu Leu Ala Trp Cys Gln Glu 
    930                 935                 940                 


Glu His Lys Asn Met Gly Tyr Tyr Asp Tyr Ile Ser Pro Arg Phe Met 
945                 950                 955                 960 


Thr Ile Leu Arg Arg Ala Arg Pro Ile Trp Tyr Val Gly Arg Asp Pro 
                965                 970                 975     


Ala Ala Ala Pro Ala Thr Gly Asn Arg Asn Thr His Leu Val Ser Leu 
            980                 985                 990         


Lys Lys Phe Leu Asp Thr Ala Phe  Asn Leu Gln Ala Phe  Glu Gly Lys 
        995                 1000                 1005             


Thr Phe  
    1010 


<210>  41
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly Arg 
            900                 905                 910         


Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala 
        915                 920                 925             


Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu 
    930                 935                 940                 


Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu 
945                 950                 955                 960 


Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970             


<210>  42
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Arg Arg Ala Ser Glu Thr Pro Glu Asp Gly Asp Pro Glu Glu 
1               5                   10                  15      


Asp Thr Ala Thr Ala Leu Gln Arg Leu Val Glu Leu Thr Thr Ser Arg 
            20                  25                  30          


Val Thr Pro Val Arg Ser Leu Arg Asp Gln Tyr His Leu Ile Arg Lys 
        35                  40                  45              


Leu Gly Ser Gly Ser Tyr Gly Arg Val Leu Leu Ala Gln Pro His Gln 
    50                  55                  60                  


Gly Gly Pro Ala Val Ala Leu Lys Leu Leu Arg Arg Asp Leu Val Leu 
65                  70                  75                  80  


Arg Ser Thr Phe Leu Arg Glu Phe Cys Val Gly Arg Cys Val Ser Ala 
                85                  90                  95      


His Pro Gly Leu Leu Gln Thr Leu Ala Gly Pro Leu Gln Thr Pro Arg 
            100                 105                 110         


Tyr Phe Ala Phe Ala Gln Glu Tyr Ala Pro Cys Gly Asp Leu Ser Gly 
        115                 120                 125             


Met Leu Gln Glu Arg Gly Leu Pro Glu Leu Leu Val Lys Arg Val Val 
    130                 135                 140                 


Ala Gln Leu Ala Gly Ala Leu Asp Phe Leu His Ser Arg Gly Leu Val 
145                 150                 155                 160 


His Ala Asp Val Lys Pro Asp Asn Val Leu Val Phe Asp Pro Val Cys 
                165                 170                 175     


Ser Arg Val Ala Leu Gly Asp Leu Gly Leu Thr Arg Pro Glu Gly Ser 
            180                 185                 190         


Pro Thr Pro Ala Pro Pro Val Pro Leu Pro Thr Ala Pro Pro Glu Leu 
        195                 200                 205             


Cys Leu Leu Leu Pro Pro Asp Thr Leu Pro Leu Arg Pro Ala Val Asp 
    210                 215                 220                 


Ser Trp Gly Leu Gly Val Leu Leu Phe Cys Ala Ala Thr Ala Cys Phe 
225                 230                 235                 240 


Pro Trp Asp Val Ala Leu Ala Pro Asn Pro Glu Phe Glu Ala Phe Ala 
                245                 250                 255     


Gly Trp Val Thr Thr Lys Pro Gln Pro Pro Gln Pro Pro Pro Pro Trp 
            260                 265                 270         


Asp Gln Phe Ala Pro Pro Ala Leu Ala Leu Leu Gln Gly Leu Leu Asp 
        275                 280                 285             


Leu Asp Pro Glu Thr Arg Ser Pro Pro Leu Ala Val Leu Asp Phe Leu 
    290                 295                 300                 


Gly Asp Asp Trp Gly Leu Gln Gly Asn Arg Glu Gly Pro Gly Val Leu 
305                 310                 315                 320 


Gly Ser Ala Val Ser Tyr Glu Asp Arg Glu Glu Gly Gly Ser Ser Leu 
                325                 330                 335     


Glu Glu Trp Thr Asp Glu Gly Asp Asp Ser Lys Ser Gly Gly Arg Thr 
            340                 345                 350         


Gly Thr Asp Gly Gly Ala Pro 
        355                 


<210>  43
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gly Ile Gly Arg Ser Glu Gly Gly Arg Arg Gly Ala Ala Leu Gly 
1               5                   10                  15      


Val Leu Leu Ala Leu Gly Ala Ala Leu Leu Ala Val Gly Ser Ala Ser 
            20                  25                  30          


Glu Tyr Asp Tyr Val Ser Phe Gln Ser Asp Ile Gly Pro Tyr Gln Ser 
        35                  40                  45              


Gly Arg Phe Tyr Thr Lys Pro Pro Gln Cys Val Asp Ile Pro Ala Asp 
    50                  55                  60                  


Leu Arg Leu Cys His Asn Val Gly Tyr Lys Lys Met Val Leu Pro Asn 
65                  70                  75                  80  


Leu Leu Glu His Glu Thr Met Ala Glu Val Lys Gln Gln Ala Ser Ser 
                85                  90                  95      


Trp Val Pro Leu Leu Asn Lys Asn Cys His Ala Gly Thr Gln Val Phe 
            100                 105                 110         


Leu Cys Ser Leu Phe Ala Pro Val Cys Leu Asp Arg Pro Ile Tyr Pro 
        115                 120                 125             


Cys Arg Trp Leu Cys Glu Ala Val Arg Asp Ser Cys Glu Pro Val Met 
    130                 135                 140                 


Gln Phe Phe Gly Phe Tyr Trp Pro Glu Met Leu Lys Cys Asp Lys Phe 
145                 150                 155                 160 


Pro Glu Gly Asp Val Cys Ile Ala Met Thr Pro Pro Asn Ala Thr Glu 
                165                 170                 175     


Ala Ser Lys Pro Gln Gly Thr Thr Val Cys Pro Pro Cys Asp Asn Glu 
            180                 185                 190         


Leu Lys Ser Glu Ala Ile Ile Glu His Leu Cys Ala Ser Glu Phe Ala 
        195                 200                 205             


Leu Arg Met Lys Ile Lys Glu Val Lys Lys Glu Asn Gly Asp Lys Lys 
    210                 215                 220                 


Ile Val Pro Lys Lys Lys Lys Pro Leu Lys Leu Gly Pro Ile Lys Lys 
225                 230                 235                 240 


Lys Asp Leu Lys Lys Leu Val Leu Tyr Leu Lys Asn Gly Ala Asp Cys 
                245                 250                 255     


Pro Cys His Gln Leu Asp Asn Leu Ser His His Phe Leu Ile Met Gly 
            260                 265                 270         


Arg Lys Val Lys Ser Gln Tyr Leu Leu Thr Ala Ile His Lys Trp Asp 
        275                 280                 285             


Lys Lys Asn Lys Glu Phe Lys Asn Phe Met Lys Lys Met Lys Asn His 
    290                 295                 300                 


Glu Cys Pro Thr Phe Gln Ser Val Phe Lys 
305                 310                 


<210>  44
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Thr Glu Arg Phe Asp Cys His His Cys Asn Glu Ser Leu Phe Gly 
1               5                   10                  15      


Lys Lys Tyr Ile Leu Arg Glu Glu Ser Pro Tyr Cys Val Val Cys Phe 
            20                  25                  30          


Glu Thr Leu Phe Ala Asn Thr Cys Glu Glu Cys Gly Lys Pro Ile Gly 
        35                  40                  45              


Cys Asp Cys Lys Asp Leu Ser Tyr Lys Asp Arg His Trp His Glu Ala 
    50                  55                  60                  


Cys Phe His Cys Ser Gln Cys Arg Asn Ser Leu Val Asp Lys Pro Phe 
65                  70                  75                  80  


Ala Ala Lys Glu Asp Gln Leu Leu Cys Thr Asp Cys Tyr Ser Asn Glu 
                85                  90                  95      


Tyr Ser Ser Lys Cys Gln Glu Cys Lys Lys Thr Ile Met Pro Gly Thr 
            100                 105                 110         


Arg Lys Met Glu Tyr Lys Gly Ser Ser Trp His Glu Thr Cys Phe Ile 
        115                 120                 125             


Cys His Arg Cys Gln Gln Pro Ile Gly Thr Lys Ser Phe Ile Pro Lys 
    130                 135                 140                 


Asp Asn Gln Asn Phe Cys Val Pro Cys Tyr Glu Lys Gln His Ala Met 
145                 150                 155                 160 


Gln Cys Val Gln Cys Lys Lys Pro Ile Thr Thr Gly Gly Val Thr Tyr 
                165                 170                 175     


Arg Glu Gln Pro Trp His Lys Glu Cys Phe Val Cys Thr Ala Cys Arg 
            180                 185                 190         


Lys Gln Leu Ser Gly Gln Arg Phe Thr Ala Arg Asp Asp Phe Ala Tyr 
        195                 200                 205             


Cys Leu Asn Cys Phe Cys Asp Leu Tyr Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Thr Asn Pro Ile Ser Gly Leu Gly Gly Thr Lys Tyr Ile Ser Phe Glu 
225                 230                 235                 240 


Glu Arg Gln Trp His Asn Asp Cys Phe Asn Cys Lys Lys Cys Ser Leu 
                245                 250                 255     


Ser Leu Val Gly Arg Gly Phe Leu Thr Glu Arg Asp Asp Ile Leu Cys 
            260                 265                 270         


Pro Asp Cys Gly Lys Asp Ile 
        275                 


<210>  45
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Arg Ala Glu Gly Leu Gly Gly Leu Glu Arg Phe Cys Ser Pro Gly 
1               5                   10                  15      


Lys Gly Arg Gly Leu Arg Ala Leu Gln Pro Phe Gln Val Gly Asp Leu 
            20                  25                  30          


Leu Phe Ser Cys Pro Ala Tyr Ala Tyr Val Leu Thr Val Asn Glu Arg 
        35                  40                  45              


Gly Asn His Cys Glu Tyr Cys Phe Thr Arg Lys Glu Gly Leu Ser Lys 
    50                  55                  60                  


Cys Gly Arg Cys Lys Gln Ala Phe Tyr Cys Asn Val Glu Cys Gln Lys 
65                  70                  75                  80  


Glu Asp Trp Pro Met His Lys Leu Glu Cys Ser Pro Met Val Val Phe 
                85                  90                  95      


Gly Glu Asn Trp Asn Pro Ser Glu Thr Val Arg Leu Thr Ala Arg Ile 
            100                 105                 110         


Leu Ala Lys Gln Lys Ile His Pro Glu Arg Thr Pro Ser Glu Lys Leu 
        115                 120                 125             


Leu Ala Val Lys Glu Phe Glu Ser His Leu Asp Lys Leu Asp Asn Glu 
    130                 135                 140                 


Lys Lys Asp Leu Ile Gln Ser Asp Ile Ala Ala Leu His His Phe Tyr 
145                 150                 155                 160 


Ser Lys His Leu Gly Phe Pro Asp Asn Asp Ser Leu Val Val Leu Phe 
                165                 170                 175     


Ala Gln Val Asn Cys Asn Gly Phe Thr Ile Glu Asp Glu Glu Leu Ser 
            180                 185                 190         


His Leu Gly Ser Ala Ile Phe Pro Asp Val Ala Leu Met Asn His Ser 
        195                 200                 205             


Cys Cys Pro Asn Val Ile Val Thr Tyr Lys Gly Thr Leu Ala Glu Val 
    210                 215                 220                 


Arg Ala Val Gln Glu Ile Lys Pro Gly Glu Glu Val Phe Thr Ser Tyr 
225                 230                 235                 240 


Ile Asp Leu Leu Tyr Pro Thr Glu Asp Arg Asn Asp Arg Leu Arg Asp 
                245                 250                 255     


Ser Tyr Phe Phe Thr Cys Glu Cys Gln Glu Cys Thr Thr Lys Asp Lys 
            260                 265                 270         


Asp Lys Ala Lys Val Glu Ile Arg Lys Leu Ser Asp Pro Pro Lys Ala 
        275                 280                 285             


Glu Ala Ile Arg Asp Met Val Arg Tyr Ala Arg Asn Val Ile Glu Glu 
    290                 295                 300                 


Phe Arg Arg Ala Lys His Tyr Lys Ser Pro Ser Glu Leu Leu Glu Ile 
305                 310                 315                 320 


Cys Glu Leu Ser Gln Glu Lys Met Ser Ser Val Phe Glu Asp Ser Asn 
                325                 330                 335     


Val Tyr Met Leu His Met Met Tyr Gln Ala Met Gly Val Cys Leu Tyr 
            340                 345                 350         


Met Gln Asp Trp Glu Gly Ala Leu Gln Tyr Gly Gln Lys Ile Ile Lys 
        355                 360                 365             


Pro Tyr Ser Lys His Tyr Pro Leu Tyr Ser Leu Asn Val Ala Ser Met 
    370                 375                 380                 


Trp Leu Lys Leu Gly Arg Leu Tyr Met Gly Leu Glu His Lys Ala Ala 
385                 390                 395                 400 


Gly Glu Lys Ala Leu Lys Lys Ala Ile Ala Ile Met Glu Val Ala His 
                405                 410                 415     


Gly Lys Asp His Pro Tyr Ile Ser Glu Ile Lys Gln Glu Ile Glu Ser 
            420                 425                 430         


His 
    


<210>  46
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Lys Lys Thr Pro Val Phe Leu Glu Ser Leu Val Thr Asn Met Leu 
1               5                   10                  15      


Arg Leu Arg Ala Ile Cys Pro Phe Ser Trp Arg Val Phe Gln Phe Arg 
            20                  25                  30          


Pro Ile Ser Cys Glu Pro Leu Ile Ile Gln Met Asn Lys Cys Thr Asp 
        35                  40                  45              


Glu Glu Gln Met Phe Gly Phe Ile Glu Arg Asn Lys Ala Ile Leu Ser 
    50                  55                  60                  


Glu Lys Gln Val Gly Cys Ala Phe Asp Met Leu Trp Lys Leu Gln Lys 
65                  70                  75                  80  


Gln Lys Thr Ser Leu Leu Lys Asn Ala Glu Tyr Val Arg Asp His Pro 
                85                  90                  95      


Gln Phe Leu Thr Leu His Asn Leu Ala Thr Asn Lys Phe Lys Leu Met 
            100                 105                 110         


Asn Asp Asp Thr Leu Val Asn Val Leu Tyr Val Thr Gln Gln Phe Ala 
        115                 120                 125             


Gly Glu Ala His Asp Pro Leu Val Glu Ala Leu Val Thr Glu Ala Trp 
    130                 135                 140                 


Arg Arg Leu Glu Arg Phe Asp Ile Lys Leu Leu Ser Glu Phe Ser Ser 
145                 150                 155                 160 


Cys Leu Ala Asp Gln His Leu Tyr Phe Ser Pro Leu Met Gly Lys Ile 
                165                 170                 175     


Ala Asp Ile Val His Arg Asn Leu Glu Thr Thr Gln Asp Leu Ser Ser 
            180                 185                 190         


Leu Ser Val Leu Met Val Asn Ile Ser Ser Leu Ile Ser Arg His Phe 
        195                 200                 205             


Gln Gln Gln Leu Val Asn Lys Thr Glu Leu Leu Phe Asp Thr Ile Asp 
    210                 215                 220                 


Ser Ser Glu Val Asn Val Ala Lys Ser Ile Ala Lys Phe Leu Arg Asn 
225                 230                 235                 240 


Val Arg Tyr Arg Tyr Gln Pro Leu Leu Glu Arg Cys Asn Asn Val Phe 
                245                 250                 255     


Leu Ser Asn Val Asp His Leu Asp Leu Asp Ser Ile Ser Lys Ile Leu 
            260                 265                 270         


Ser Val Tyr Lys Phe Leu Gln Phe Asn Ser Phe Glu Phe Ile Ile Met 
        275                 280                 285             


Ala Lys Lys Lys Leu Thr Glu Met Ile Pro Leu Cys Asn His Pro Ala 
    290                 295                 300                 


Ser Phe Val Lys Leu Phe Val Ala Leu Gly Pro Ile Ala Gly Pro Glu 
305                 310                 315                 320 


Glu Lys Lys Gln Leu Lys Ser Thr Met Leu Leu Met Ser Glu Asp Leu 
                325                 330                 335     


Thr Gly Glu Gln Ala Leu Ala Val Leu Gly Ala Met Gly Asp Met Glu 
            340                 345                 350         


Ser Arg Asn Ser Cys Leu Ile Lys Arg Val Thr Ser Val Leu His Lys 
        355                 360                 365             


His Leu Asp Gly Tyr Lys Pro Leu Glu Leu Leu Lys Ile Thr Gln Glu 
    370                 375                 380                 


Leu Thr Phe Leu His Phe Gln Arg Lys Glu Phe Phe Ala Lys Leu Arg 
385                 390                 395                 400 


Glu Leu Leu Leu Ser Tyr Leu Lys Asn Ser Phe Ile Pro Thr Glu Val 
                405                 410                 415     


Ser Val Leu Val Arg Ala Ile Ser Leu Leu Pro Ser Pro His Leu Asp 
            420                 425                 430         


Glu Val Gly Ile Ser Arg Ile Glu Ala Val Leu Pro Gln Cys Asp Leu 
        435                 440                 445             


Asn Asn Leu Ser Ser Phe Ala Thr Ser Val Leu Arg Trp Ile Gln His 
    450                 455                 460                 


Asp His Met Tyr Leu Asp Asn Met Thr Ala Lys Gln Leu Lys Leu Leu 
465                 470                 475                 480 


Gln Lys Leu Asp His Tyr Gly Arg Gln Arg Leu Gln His Ser Asn Ser 
                485                 490                 495     


Leu Asp Leu Leu Arg Lys Glu Leu Lys Ser Leu Lys Gly Asn Thr Phe 
            500                 505                 510         


Pro Glu Ser Leu Leu Glu Glu Met Ile Ala Thr Leu Gln His Phe Met 
        515                 520                 525             


Asp Asp Ile Asn Tyr Ile Asn Val Gly Glu Ile Ala Ser Phe Ile Ser 
    530                 535                 540                 


Ser Thr Asp Tyr Leu Ser Thr Leu Leu Leu Asp Arg Ile Ala Ser Val 
545                 550                 555                 560 


Ala Val Gln Gln Ile Glu Lys Ile His Pro Phe Thr Ile Pro Ala Ile 
                565                 570                 575     


Ile Arg Pro Phe Ser Val Leu Asn Tyr Asp Pro Pro Gln Arg Asp Glu 
            580                 585                 590         


Phe Leu Gly Thr Cys Val Gln His Leu Asn Ser Tyr Leu Gly Ile Leu 
        595                 600                 605             


Asp Pro Phe Ile Leu Val Phe Leu Gly Phe Ser Leu Ala Thr Leu Glu 
    610                 615                 620                 


Tyr Phe Pro Glu Asp Leu Leu Lys Ala Ile Phe Asn Ile Lys Phe Leu 
625                 630                 635                 640 


Ala Arg Leu Asp Ser Gln Leu Glu Ile Leu Ser Pro Ser Arg Ser Ala 
                645                 650                 655     


Arg Val Gln Phe His Leu Met Glu Leu Asn Arg Ser Val Cys Leu Glu 
            660                 665                 670         


Cys Pro Glu Phe Gln Ile Pro Trp Phe His Asp Arg Phe Cys Gln Gln 
        675                 680                 685             


Tyr Asn Lys Gly Ile Gly Gly Met Asp Gly Thr Gln Gln Gln Ile Phe 
    690                 695                 700                 


Lys Met Leu Ala Glu Val Leu Gly Gly Ile Asn Cys Val Lys Ala Ser 
705                 710                 715                 720 


Val Leu Thr Pro Tyr Tyr His Lys Val Asp Phe Glu Cys Ile Leu Asp 
                725                 730                 735     


Lys Arg Lys Lys Pro Leu Pro Tyr Gly Ser His Asn Ile Ala Leu Gly 
            740                 745                 750         


Gln Leu Pro Glu Met Pro Trp Glu Ser Asn Ile Glu Ile Val Gly Ser 
        755                 760                 765             


Arg Leu Pro Pro Gly Ala Glu Arg Ile Ala Leu Glu Phe Leu Asp Ser 
    770                 775                 780                 


Lys Ala Leu Cys Arg Asn Ile Pro His Met Lys Gly Lys Ser Ala Met 
785                 790                 795                 800 


Lys Lys Arg His Leu Glu Ile Leu Gly Tyr Arg Val Ile Gln Ile Ser 
                805                 810                 815     


Gln Phe Glu Trp Asn Ser Met Ala Leu Ser Thr Lys Asp Ala Arg Met 
            820                 825                 830         


Asp Tyr Leu Arg Glu Cys Ile Phe Gly Glu Val Lys Ser Cys Leu 
        835                 840                 845         


<210>  47
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Pro Gln Val Val Ala Ser Ala Pro Glu Pro Thr Arg Pro Pro 
1               5                   10                  15      


Ser Gly Phe Val Pro Val Ser Gly Gly Gly Gly Thr His Val Thr Gln 
            20                  25                  30          


Val His Ile Gln Leu Ala Pro Ser Pro His Asn Gly Thr Pro Glu Pro 
        35                  40                  45              


Pro Arg Thr Ala Pro Glu Val Gly Ser Asn Ser Gln Asp Gly Asp Ala 
    50                  55                  60                  


Thr Pro Ser Pro Pro Arg Ala Gln Pro Leu Val Pro Val Ala His Ile 
65                  70                  75                  80  


Arg Pro Leu Pro Thr Thr Val Gln Ala Ala Ser Pro Leu Pro Glu Glu 
                85                  90                  95      


Pro Pro Val Pro Arg Pro Pro Pro Gly Phe Gln Ala Ser Val Pro Arg 
            100                 105                 110         


Glu Ala Ser Ala Arg Val Val Val Pro Ile Ala Pro Thr Cys Arg Ser 
        115                 120                 125             


Leu Glu Ser Ser Pro His Ser Leu Val Pro Met Gly Pro Gly Arg Glu 
    130                 135                 140                 


His Leu Glu Glu Pro Pro Met Ala Gly Pro Ala Ala Glu Ala Glu Arg 
145                 150                 155                 160 


Val Ser Ser Pro Ala Trp Ala Ser Ser Pro Thr Pro Pro Ser Gly Pro 
                165                 170                 175     


His Pro Cys Pro Val Pro Lys Val Ala Pro Lys Pro Arg Leu Ser Gly 
            180                 185                 190         


Trp Thr Trp Leu Lys Lys Gln Leu Leu Glu Glu Ala Pro Glu Pro Pro 
        195                 200                 205             


Cys Pro Glu Pro Arg Gln Ser Leu Glu Pro Glu Val Pro Thr Pro Thr 
    210                 215                 220                 


Glu Gln Glu Val Pro Ala Pro Thr Glu Gln Glu Val Pro Ala Leu Thr 
225                 230                 235                 240 


Ala Pro Arg Ala Pro Ala Ser Arg Thr Ser Arg Met Trp Asp Ala Val 
                245                 250                 255     


Leu Tyr Arg Met Ser Val Ala Glu Ala Gln Gly Arg Leu Ala Gly Pro 
            260                 265                 270         


Ser Gly Gly Glu His Thr Pro Ala Ser Leu Thr Arg Leu Pro Phe Leu 
        275                 280                 285             


Tyr Arg Pro Arg Phe Asn Ala Arg Lys Leu Gln Glu Ala Thr Arg Pro 
    290                 295                 300                 


Pro Pro Thr Val Arg Ser Ile Leu Glu Leu Ser Pro Gln Pro Lys Asn 
305                 310                 315                 320 


Phe Asn Arg Thr Ala Thr Gly Trp Arg Leu Gln 
                325                 330     


<210>  48
<211>  1100
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
    50                  55                  60                  


Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg Pro Lys Asp 
                85                  90                  95      


Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val His Lys Pro Asp 
            100                 105                 110         


Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr Asn Ala Gly Leu 
        115                 120                 125             


Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro Ala Ala Lys Thr Gln 
    130                 135                 140                 


Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn Ser Pro Asn Ala 
145                 150                 155                 160 


Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro His Val Pro Pro Pro 
                165                 170                 175     


Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr Glu Lys His Asp 
            180                 185                 190         


Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu 
        195                 200                 205             


Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln 
    210                 215                 220                 


His Glu Arg Pro Ala Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu 
225                 230                 235                 240 


Glu Arg Pro Met Ser Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg 
                245                 250                 255     


Arg Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln 
            260                 265                 270         


Ser Ala Ser Arg Thr Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser 
        275                 280                 285             


Thr Thr Leu Thr Lys Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser 
    290                 295                 300                 


Arg Ala Lys Gly Gly Asp Asp Ser Lys Ile Cys Pro Ser Leu Cys Ser 
305                 310                 315                 320 


Tyr Ser Gly Leu Asn Gly Asn Pro Ser Ser Glu Leu Asp Tyr Cys Ser 
                325                 330                 335     


Thr Tyr Arg Gln His Leu Asp Val Pro Arg Asp Ser Pro Arg Ala Ile 
            340                 345                 350         


Ser Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn Ala Glu Ile Trp 
        355                 360                 365             


Ser Ser Thr Glu Glu Thr Val Ser Pro Lys Ile Lys Ser Arg Ser Cys 
    370                 375                 380                 


Asp Asp Leu Leu Asn Asp Asp Cys Asp Ser Phe Pro Asp Pro Lys Val 
385                 390                 395                 400 


Lys Ser Glu Ser Met Gly Ser Leu Leu Cys Glu Glu Asp Ser Lys Glu 
                405                 410                 415     


Ser Cys Pro Met Ala Trp Gly Ser Pro Tyr Val Pro Glu Val Arg Ser 
            420                 425                 430         


Asn Gly Arg Ser Arg Ile Arg His Arg Ser Ala Arg Asn Ala Pro Gly 
        435                 440                 445             


Phe Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn Arg Lys Asp Leu 
    450                 455                 460                 


Met Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg Ile Leu Gln Tyr 
465                 470                 475                 480 


Glu Ser Glu Gln Gln His Lys Asp Leu Leu Arg Ala Trp Ser Gln Cys 
                485                 490                 495     


Ser Thr Glu Glu Val Pro Arg Asp Met Val Pro Thr Arg Ile Ser Glu 
            500                 505                 510         


Phe Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro Asn Leu Gly Asp 
        515                 520                 525             


Asp Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln Asn Gly Leu Cys 
    530                 535                 540                 


Pro Lys Arg Arg Phe Ser Ile Glu Tyr Leu Leu Glu Glu Glu Asn Gln 
545                 550                 555                 560 


Ser Gly Pro Pro Ala Arg Gly Arg Arg Gly Cys Gln Ser Asn Ala Leu 
                565                 570                 575     


Val Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln Pro Arg Ala His 
            580                 585                 590         


Val Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val Ser Asp His Ser 
        595                 600                 605             


Asp Tyr Ile His Leu Glu Gly Ser Ser Phe Cys Ser Glu Ser Asp Phe 
    610                 615                 620                 


Asp His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr Gly Ser Ser His 
625                 630                 635                 640 


His His His His His His His His His His Arg His Leu Ile Ser Ser 
                645                 650                 655     


Cys Lys Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe Thr Thr Met Leu 
            660                 665                 670         


Lys His Glu Arg Ala Arg His Glu Asn Thr Glu Glu Pro Arg Arg Gln 
        675                 680                 685             


Glu Met Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu Val Ser Pro Val 
    690                 695                 700                 


Pro Phe Arg Arg Lys Lys Asn Ser Ala Pro Lys Lys Gln Thr Glu Lys 
705                 710                 715                 720 


Ala Lys Cys Lys Ala Ser Val Phe Glu Ala Leu Asp Ser Ala Leu Lys 
                725                 730                 735     


Asp Ile Cys Asp Gln Ile Lys Ala Glu Lys Lys Arg Gly Ser Leu Pro 
            740                 745                 750         


Asp Asn Ser Ile Leu His Arg Leu Ile Ser Glu Leu Leu Pro Asp Val 
        755                 760                 765             


Pro Glu Arg Asn Ser Ser Leu Arg Ala Leu Arg Arg Ser Pro Leu His 
    770                 775                 780                 


Gln Pro Leu His Pro Leu Pro Pro Asp Gly Ala Ile His Cys Pro Pro 
785                 790                 795                 800 


Tyr Gln Asn Asp Cys Gly Arg Met Pro Arg Ser Ala Ser Phe Gln Asp 
                805                 810                 815     


Val Asp Thr Ala Asn Ser Ser Cys His His Gln Asp Arg Gly Gly Ala 
            820                 825                 830         


Leu Gln Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp 
        835                 840                 845             


Met Gly Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu 
    850                 855                 860                 


Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys 
865                 870                 875                 880 


Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile 
                885                 890                 895     


Asp Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe 
            900                 905                 910         


Pro Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro 
        915                 920                 925             


Ala Arg Pro Pro Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile 
    930                 935                 940                 


Ala Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg 
945                 950                 955                 960 


Lys Gly Asp Arg Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr 
                965                 970                 975     


Glu Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser 
            980                 985                 990         


Tyr Val Glu Val Val Lys Lys Asn  Thr Lys Gly Ala Glu  Asp Tyr Pro 
        995                 1000                 1005             


Asp Pro  Pro Ile Pro His Ser  Tyr Ser Ser Asp Arg  Ile His Ser 
    1010                 1015                 1020             


Leu Ser  Ser Asn Lys Pro Gln  Arg Pro Val Phe Thr  His Glu Asn 
    1025                 1030                 1035             


Ile Gln  Gly Gly Gly Glu Pro  Phe Gln Ala Leu Tyr  Asn Tyr Thr 
    1040                 1045                 1050             


Pro Arg  Asn Glu Asp Glu Leu  Glu Leu Arg Glu Ser  Asp Val Ile 
    1055                 1060                 1065             


Asp Val  Met Glu Lys Cys Asp  Asp Gly Trp Phe Val  Gly Thr Ser 
    1070                 1075                 1080             


Arg Arg  Thr Lys Phe Phe Gly  Thr Phe Pro Gly Asn  Tyr Val Lys 
    1085                 1090                 1095             


Arg Leu  
    1100 


<210>  49
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Lys Cys Thr Ala Arg Glu Trp Leu Arg Val Thr Thr Val Leu Phe 
1               5                   10                  15      


Met Ala Arg Ala Ile Pro Ala Met Val Val Pro Asn Ala Thr Leu Leu 
            20                  25                  30          


Glu Lys Leu Leu Glu Lys Tyr Met Asp Glu Asp Gly Glu Trp Trp Ile 
        35                  40                  45              


Ala Lys Gln Arg Gly Lys Arg Ala Ile Thr Asp Asn Asp Met Gln Ser 
    50                  55                  60                  


Ile Leu Asp Leu His Asn Lys Leu Arg Ser Gln Val Tyr Pro Thr Ala 
65                  70                  75                  80  


Ser Asn Met Glu Tyr Met Thr Trp Asp Val Glu Leu Glu Arg Ser Ala 
                85                  90                  95      


Glu Ser Trp Ala Glu Ser Cys Leu Trp Glu His Gly Pro Ala Ser Leu 
            100                 105                 110         


Leu Pro Ser Ile Gly Gln Asn Leu Gly Ala His Trp Gly Arg Tyr Arg 
        115                 120                 125             


Pro Pro Thr Phe His Val Gln Ser Trp Tyr Asp Glu Val Lys Asp Phe 
    130                 135                 140                 


Ser Tyr Pro Tyr Glu His Glu Cys Asn Pro Tyr Cys Pro Phe Arg Cys 
145                 150                 155                 160 


Ser Gly Pro Val Cys Thr His Tyr Thr Gln Val Val Trp Ala Thr Ser 
                165                 170                 175     


Asn Arg Ile Gly Cys Ala Ile Asn Leu Cys His Asn Met Asn Ile Trp 
            180                 185                 190         


Gly Gln Ile Trp Pro Lys Ala Val Tyr Leu Val Cys Asn Tyr Ser Pro 
        195                 200                 205             


Lys Gly Asn Trp Trp Gly His Ala Pro Tyr Lys His Gly Arg Pro Cys 
    210                 215                 220                 


Ser Ala Cys Pro Pro Ser Phe Gly Gly Gly Cys Arg Glu Asn Leu Cys 
225                 230                 235                 240 


Tyr Lys Glu Gly Ser Asp Arg Tyr Tyr Pro Pro Arg Glu Glu Glu Thr 
                245                 250                 255     


Asn Glu Ile Glu Arg Gln Gln Ser Gln Val His Asp Thr His Val Arg 
            260                 265                 270         


Thr Arg Ser Asp Asp Ser Ser Arg Asn Glu Val Ile Ser Ala Gln Gln 
        275                 280                 285             


Met Ser Gln Ile Val Ser Cys Glu Val Arg Leu Arg Asp Gln Cys Lys 
    290                 295                 300                 


Gly Thr Thr Cys Asn Arg Tyr Glu Cys Pro Ala Gly Cys Leu Asp Ser 
305                 310                 315                 320 


Lys Ala Lys Val Ile Gly Ser Val His Tyr Glu Met Gln Ser Ser Ile 
                325                 330                 335     


Cys Arg Ala Ala Ile His Tyr Gly Ile Ile Asp Asn Asp Gly Gly Trp 
            340                 345                 350         


Val Asp Ile Thr Arg Gln Gly Arg Lys His Tyr Phe Ile Lys Ser Asn 
        355                 360                 365             


Arg Asn Gly Ile Gln Thr Ile Gly Lys Tyr Gln Ser Ala Asn Ser Phe 
    370                 375                 380                 


Thr Val Ser Lys Val Thr Val Gln Ala Val Thr Cys Glu Thr Thr Val 
385                 390                 395                 400 


Glu Gln Leu Cys Pro Phe His Lys Pro Ala Ser His Cys Pro Arg Val 
                405                 410                 415     


Tyr Cys Pro Arg Asn Cys Met Gln Ala Asn Pro His Tyr Ala Arg Val 
            420                 425                 430         


Ile Gly Thr Arg Val Tyr Ser Asp Leu Ser Ser Ile Cys Arg Ala Ala 
        435                 440                 445             


Val His Ala Gly Val Val Arg Asn His Gly Gly Tyr Val Asp Val Met 
    450                 455                 460                 


Pro Val Asp Lys Arg Lys Thr Tyr Ile Ala Ser Phe Gln Asn Gly Ile 
465                 470                 475                 480 


Phe Ser Glu Ser Leu Gln Asn Pro Pro Gly Gly Lys Ala Phe Arg Val 
                485                 490                 495     


Phe Ala Val Val 
            500 


<210>  50
<211>  1426
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asn Asp Trp His Arg Ile Phe Thr Gln Asn Val Leu Val Pro Pro 
1               5                   10                  15      


His Pro Gln Arg Ala Arg Gln Pro Trp Lys Glu Ser Thr Ala Phe Gln 
            20                  25                  30          


Cys Val Leu Lys Trp Leu Asp Gly Pro Val Ile Arg Gln Gly Val Leu 
        35                  40                  45              


Glu Val Leu Ser Glu Val Glu Cys His Leu Arg Val Ser Phe Phe Asp 
    50                  55                  60                  


Val Thr Tyr Arg His Phe Phe Gly Arg Thr Trp Lys Thr Thr Val Lys 
65                  70                  75                  80  


Pro Thr Lys Arg Pro Pro Ser Arg Ile Val Phe Asn Glu Pro Leu Tyr 
                85                  90                  95      


Phe His Thr Ser Leu Asn His Pro His Ile Val Ala Val Val Glu Val 
            100                 105                 110         


Val Ala Glu Gly Lys Lys Arg Asp Gly Ser Leu Gln Thr Leu Ser Cys 
        115                 120                 125             


Gly Phe Gly Ile Leu Arg Ile Phe Ser Asn Gln Pro Asp Ser Pro Ile 
    130                 135                 140                 


Ser Ala Ser Gln Asp Lys Arg Leu Arg Leu Tyr His Gly Thr Pro Arg 
145                 150                 155                 160 


Ala Leu Leu His Pro Leu Leu Gln Asp Pro Ala Glu Gln Asn Arg His 
                165                 170                 175     


Met Thr Leu Ile Glu Asn Cys Ser Leu Gln Tyr Thr Leu Lys Pro His 
            180                 185                 190         


Pro Ala Leu Glu Pro Ala Phe His Leu Leu Pro Glu Asn Leu Leu Val 
        195                 200                 205             


Ser Gly Leu Gln Gln Ile Pro Gly Leu Leu Pro Ala His Gly Glu Ser 
    210                 215                 220                 


Gly Asp Ala Leu Arg Lys Pro Arg Leu Gln Lys Pro Ile Thr Gly His 
225                 230                 235                 240 


Leu Asp Asp Leu Phe Phe Thr Leu Tyr Pro Ser Leu Glu Lys Phe Glu 
                245                 250                 255     


Glu Glu Leu Leu Glu Leu His Val Gln Asp His Phe Gln Glu Gly Cys 
            260                 265                 270         


Gly Pro Leu Asp Gly Gly Ala Leu Glu Ile Leu Glu Arg Arg Leu Arg 
        275                 280                 285             


Val Gly Val His Asn Gly Leu Gly Phe Val Gln Arg Pro Gln Val Val 
    290                 295                 300                 


Val Leu Val Pro Glu Met Asp Val Ala Leu Thr Arg Ser Ala Ser Phe 
305                 310                 315                 320 


Ser Arg Lys Val Val Ser Ser Ser Lys Thr Ser Ser Gly Ser Gln Ala 
                325                 330                 335     


Leu Val Leu Arg Ser Arg Leu Arg Leu Pro Glu Met Val Gly His Pro 
            340                 345                 350         


Ala Phe Ala Val Ile Phe Gln Leu Glu Tyr Val Phe Ser Ser Pro Ala 
        355                 360                 365             


Gly Val Asp Gly Asn Ala Ala Ser Val Thr Ser Leu Ser Asn Leu Ala 
    370                 375                 380                 


Cys Met His Met Val Arg Trp Ala Val Trp Asn Pro Leu Leu Glu Ala 
385                 390                 395                 400 


Asp Ser Gly Arg Val Thr Leu Pro Leu Gln Gly Gly Ile Gln Pro Asn 
                405                 410                 415     


Pro Ser His Cys Leu Val Tyr Lys Val Pro Ser Ala Ser Met Ser Ser 
            420                 425                 430         


Glu Glu Val Lys Gln Val Glu Ser Gly Thr Leu Arg Phe Gln Phe Ser 
        435                 440                 445             


Leu Gly Ser Glu Glu His Leu Asp Ala Pro Thr Glu Pro Val Ser Gly 
    450                 455                 460                 


Pro Lys Val Glu Arg Arg Pro Ser Arg Lys Pro Pro Thr Ser Pro Ser 
465                 470                 475                 480 


Ser Pro Pro Ala Pro Val Pro Arg Val Leu Ala Ala Pro Gln Asn Ser 
                485                 490                 495     


Pro Val Gly Pro Gly Leu Ser Ile Ser Gln Leu Ala Ala Ser Pro Arg 
            500                 505                 510         


Ser Pro Thr Gln His Cys Leu Ala Arg Pro Thr Ser Gln Leu Pro His 
        515                 520                 525             


Gly Ser Gln Ala Ser Pro Ala Gln Ala Gln Glu Phe Pro Leu Glu Ala 
    530                 535                 540                 


Gly Ile Ser His Leu Glu Ala Asp Leu Ser Gln Thr Ser Leu Val Leu 
545                 550                 555                 560 


Glu Thr Ser Ile Ala Glu Gln Leu Gln Glu Leu Pro Phe Thr Pro Leu 
                565                 570                 575     


His Ala Pro Ile Val Val Gly Thr Gln Thr Arg Ser Ser Ala Gly Gln 
            580                 585                 590         


Pro Ser Arg Ala Ser Met Val Leu Leu Gln Ser Ser Gly Phe Pro Glu 
        595                 600                 605             


Ile Leu Asp Ala Asn Lys Gln Pro Ala Glu Ala Val Ser Ala Thr Glu 
    610                 615                 620                 


Pro Val Thr Phe Asn Pro Gln Lys Glu Glu Ser Asp Cys Leu Gln Ser 
625                 630                 635                 640 


Asn Glu Met Val Leu Gln Phe Leu Ala Phe Ser Arg Val Ala Gln Asp 
                645                 650                 655     


Cys Arg Gly Thr Ser Trp Pro Lys Thr Val Tyr Phe Thr Phe Gln Phe 
            660                 665                 670         


Tyr Arg Phe Pro Pro Ala Thr Thr Pro Arg Leu Gln Leu Val Gln Leu 
        675                 680                 685             


Asp Glu Ala Gly Gln Pro Ser Ser Gly Ala Leu Thr His Ile Leu Val 
    690                 695                 700                 


Pro Val Ser Arg Asp Gly Thr Phe Asp Ala Gly Ser Pro Gly Phe Gln 
705                 710                 715                 720 


Leu Arg Tyr Met Val Gly Pro Gly Phe Leu Lys Pro Gly Glu Arg Arg 
                725                 730                 735     


Cys Phe Ala Arg Tyr Leu Ala Val Gln Thr Leu Gln Ile Asp Val Trp 
            740                 745                 750         


Asp Gly Asp Ser Leu Leu Leu Ile Gly Ser Ala Ala Val Gln Met Lys 
        755                 760                 765             


His Leu Leu Arg Gln Gly Arg Pro Ala Val Gln Ala Ser His Glu Leu 
    770                 775                 780                 


Glu Val Val Ala Thr Glu Tyr Glu Gln Asp Asn Met Val Val Ser Gly 
785                 790                 795                 800 


Asp Met Leu Gly Phe Gly Arg Val Lys Pro Ile Gly Val His Ser Val 
                805                 810                 815     


Val Lys Gly Arg Leu His Leu Thr Leu Ala Asn Val Gly His Pro Cys 
            820                 825                 830         


Glu Gln Lys Val Arg Gly Cys Ser Thr Leu Pro Pro Ser Arg Ser Arg 
        835                 840                 845             


Val Ile Ser Asn Asp Gly Ala Ser Arg Phe Ser Gly Gly Ser Leu Leu 
    850                 855                 860                 


Thr Thr Gly Ser Ser Arg Arg Lys His Val Val Gln Ala Gln Lys Leu 
865                 870                 875                 880 


Ala Asp Val Asp Ser Glu Leu Ala Ala Met Leu Leu Thr His Ala Arg 
                885                 890                 895     


Gln Gly Lys Gly Pro Gln Asp Val Ser Arg Glu Ser Asp Ala Thr Arg 
            900                 905                 910         


Arg Arg Lys Leu Glu Arg Met Arg Ser Val Arg Leu Gln Glu Ala Gly 
        915                 920                 925             


Gly Asp Leu Gly Arg Arg Gly Thr Ser Val Leu Ala Gln Gln Ser Val 
    930                 935                 940                 


Arg Thr Gln His Leu Arg Asp Leu Gln Val Ile Ala Ala Tyr Arg Glu 
945                 950                 955                 960 


Arg Thr Lys Ala Glu Ser Ile Ala Ser Leu Leu Ser Leu Ala Ile Thr 
                965                 970                 975     


Thr Glu His Thr Leu His Ala Thr Leu Gly Val Ala Glu Phe Phe Glu 
            980                 985                 990         


Phe Val Leu Lys Asn Pro His Asn  Thr Gln His Thr Val  Thr Val Glu 
        995                 1000                 1005             


Ile Asp  Asn Pro Glu Leu Ser  Val Ile Val Asp Ser  Gln Glu Trp 
    1010                 1015                 1020             


Arg Asp  Phe Lys Gly Ala Ala  Gly Leu His Thr Pro  Val Glu Glu 
    1025                 1030                 1035             


Asp Met  Phe His Leu Arg Gly  Ser Leu Ala Pro Gln  Leu Tyr Leu 
    1040                 1045                 1050             


Arg Pro  His Glu Thr Ala His  Val Pro Phe Lys Phe  Gln Ser Phe 
    1055                 1060                 1065             


Ser Ala  Gly Gln Leu Ala Met  Val Gln Ala Ser Pro  Gly Leu Ser 
    1070                 1075                 1080             


Asn Glu  Lys Gly Met Asp Ala  Val Ser Pro Trp Lys  Ser Ser Ala 
    1085                 1090                 1095             


Val Pro  Thr Lys His Ala Lys  Val Leu Phe Arg Ala  Ser Gly Gly 
    1100                 1105                 1110             


Lys Pro  Ile Ala Val Leu Cys  Leu Thr Val Glu Leu  Gln Pro His 
    1115                 1120                 1125             


Val Val  Asp Gln Val Phe Arg  Phe Tyr His Pro Glu  Leu Ser Phe 
    1130                 1135                 1140             


Leu Lys  Lys Ala Ile Arg Leu  Pro Pro Trp His Thr  Phe Pro Gly 
    1145                 1150                 1155             


Ala Pro  Val Gly Met Leu Gly  Glu Asp Pro Pro Val  His Val Arg 
    1160                 1165                 1170             


Cys Ser  Asp Pro Asn Val Ile  Cys Glu Thr Gln Asn  Val Gly Pro 
    1175                 1180                 1185             


Gly Glu  Pro Arg Asp Ile Phe  Leu Lys Val Ala Ser  Gly Pro Ser 
    1190                 1195                 1200             


Pro Glu  Ile Lys Asp Phe Phe  Val Ile Ile Tyr Ser  Asp Arg Trp 
    1205                 1210                 1215             


Leu Ala  Thr Pro Thr Gln Thr  Trp Gln Val Tyr Leu  His Ser Leu 
    1220                 1225                 1230             


Gln Arg  Val Asp Val Ser Cys  Val Ala Gly Gln Leu  Thr Arg Leu 
    1235                 1240                 1245             


Ser Leu  Val Leu Arg Gly Thr  Gln Thr Val Arg Lys  Val Arg Ala 
    1250                 1255                 1260             


Phe Thr  Ser His Pro Gln Glu  Leu Lys Thr Asp Pro  Lys Gly Val 
    1265                 1270                 1275             


Phe Val  Leu Pro Pro Arg Gly  Val Gln Asp Leu His  Val Gly Val 
    1280                 1285                 1290             


Arg Pro  Leu Arg Ala Gly Ser  Arg Phe Val His Leu  Asn Leu Val 
    1295                 1300                 1305             


Asp Val  Asp Cys His Gln Leu  Val Ala Ser Trp Leu  Val Cys Leu 
    1310                 1315                 1320             


Cys Cys  Arg Gln Pro Leu Ile  Ser Lys Ala Phe Glu  Ile Met Leu 
    1325                 1330                 1335             


Ala Ala  Gly Glu Gly Lys Gly  Val Asn Lys Arg Ile  Thr Tyr Thr 
    1340                 1345                 1350             


Asn Pro  Tyr Pro Ser Arg Arg  Thr Phe His Leu His  Ser Asp His 
    1355                 1360                 1365             


Pro Glu  Leu Leu Arg Phe Arg  Glu Asp Ser Phe Gln  Val Gly Gly 
    1370                 1375                 1380             


Gly Glu  Thr Tyr Thr Ile Gly  Leu Gln Phe Ala Pro  Ser Gln Arg 
    1385                 1390                 1395             


Val Gly  Glu Glu Glu Ile Leu  Ile Tyr Ile Asn Asp  His Glu Asp 
    1400                 1405                 1410             


Lys Asn  Glu Glu Ala Phe Cys  Val Lys Val Ile Tyr  Gln 
    1415                 1420                 1425     


<210>  51
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Lys Ala Pro Ser Trp Ala Gly Val Gly Ala Leu Ala Tyr Lys 
1               5                   10                  15      


Ala Pro Glu Ala Leu Trp Pro Ala Glu Ala Val Met Asp Gly Thr Met 
            20                  25                  30          


Glu Asp Ser Glu Ala Val Gln Arg Ala Thr Ala Leu Ile Glu Gln Arg 
        35                  40                  45              


Leu Ala Gln Glu Glu Glu Asn Glu Lys Leu Arg Gly Asp Ala Arg Gln 
    50                  55                  60                  


Lys Leu Pro Met Asp Leu Leu Val Leu Glu Asp Glu Lys His His Gly 
65                  70                  75                  80  


Ala Gln Ser Ala Ala Leu Gln Lys Val Lys Gly Gln Glu Arg Val Arg 
                85                  90                  95      


Lys Thr Ser Leu Asp Leu Arg Arg Glu Ile Ile Asp Val Gly Gly Ile 
            100                 105                 110         


Gln Asn Leu Ile Glu Leu Arg Lys Lys Arg Lys Gln Lys Lys Arg Asp 
        115                 120                 125             


Ala Leu Ala Ala Ser His Glu Pro Pro Pro Glu Pro Glu Glu Ile Thr 
    130                 135                 140                 


Gly Pro Val Asp Glu Glu Thr Phe Leu Lys Ala Ala Val Glu Gly Lys 
145                 150                 155                 160 


Met Lys Val Ile Glu Lys Phe Leu Ala Asp Gly Gly Ser Ala Asp Thr 
                165                 170                 175     


Cys Asp Gln Phe Arg Arg Thr Ala Leu His Arg Ala Ser Leu Glu Gly 
            180                 185                 190         


His Met Glu Ile Leu Glu Lys Leu Leu Asp Asn Gly Ala Thr Val Asp 
        195                 200                 205             


Phe Gln Asp Arg Leu Asp Cys Thr Ala Met His Trp Ala Cys Arg Gly 
    210                 215                 220                 


Gly His Leu Glu Val Val Lys Leu Leu Gln Ser His Gly Ala Asp Thr 
225                 230                 235                 240 


Asn Val Arg Asp Lys Leu Leu Ser Thr Pro Leu His Val Ala Val Arg 
                245                 250                 255     


Thr Gly Gln Val Glu Ile Val Glu His Phe Leu Ser Leu Gly Leu Glu 
            260                 265                 270         


Ile Asn Ala Arg Asp Arg Glu Gly Asp Thr Ala Leu His Asp Ala Val 
        275                 280                 285             


Arg Leu Asn Arg Tyr Lys Ile Ile Lys Leu Leu Leu Leu His Gly Ala 
    290                 295                 300                 


Asp Met Met Thr Lys Asn Leu Ala Gly Lys Thr Pro Thr Asp Leu Val 
305                 310                 315                 320 


Gln Leu Trp Gln Ala Asp Thr Arg His Ala Leu Glu His Pro Glu Pro 
                325                 330                 335     


Gly Ala Glu His Asn Gly Leu Glu Gly Pro Asn Asp Ser Gly Arg Glu 
            340                 345                 350         


Thr Pro Gln Pro Val Pro Ala Gln 
        355                 360 


<210>  52
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Lys Glu Glu Pro Gln Ser Ile Ser Arg Asp Leu Gln Glu Leu 
1               5                   10                  15      


Gln Lys Lys Leu Ser Leu Leu Ile Asp Ser Phe Gln Asn Asn Ser Lys 
            20                  25                  30          


Val Val Ala Phe Met Lys Ser Pro Val Gly Gln Tyr Leu Asp Ser His 
        35                  40                  45              


Pro Phe Leu Ala Phe Thr Leu Leu Val Phe Ile Val Met Ser Ala Val 
    50                  55                  60                  


Pro Val Gly Phe Phe Leu Leu Ile Val Val Leu Thr Thr Leu Ala Ala 
65                  70                  75                  80  


Leu Leu Gly Val Ile Ile Leu Glu Gly Leu Val Ile Ser Val Gly Gly 
                85                  90                  95      


Phe Ser Leu Leu Cys Ile Leu Cys Gly Leu Gly Phe Val Ser Leu Ala 
            100                 105                 110         


Met Ser Gly Met Met Ile Ala Ser Tyr Val Val Val Ser Ser Leu Ile 
        115                 120                 125             


Ser Cys Trp Phe Ser Pro Arg Pro Leu Thr Gln Gln Asn Thr Ser Cys 
    130                 135                 140                 


Asp Phe Leu Pro Ala Met Lys Ser Ala Glu Phe Glu Gly Leu Tyr Gln 
145                 150                 155                 160 


Glu 
    


<210>  53
<211>  1500
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly 
1               5                   10                  15      


Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys 
            20                  25                  30          


Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala 
        35                  40                  45              


Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu 
    50                  55                  60                  


Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp Pro 
65                  70                  75                  80  


Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser Leu 
                85                  90                  95      


Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly 
            100                 105                 110         


Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val Thr 
        115                 120                 125             


Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val Pro 
    130                 135                 140                 


Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala Cys 
145                 150                 155                 160 


Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met Lys 
                165                 170                 175     


Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys 
            180                 185                 190         


Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn 
        195                 200                 205             


Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu Glu 
    210                 215                 220                 


Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys Lys 
225                 230                 235                 240 


Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu Lys 
                245                 250                 255     


Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro Ser 
            260                 265                 270         


Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His Cys 
        275                 280                 285             


Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr 
    290                 295                 300                 


Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys 
305                 310                 315                 320 


Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile Glu 
                325                 330                 335     


Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val Glu 
            340                 345                 350         


Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro Leu 
        355                 360                 365             


Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp 
    370                 375                 380                 


Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser 
385                 390                 395                 400 


Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser Asn 
                405                 410                 415     


Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg 
            420                 425                 430         


Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn 
        435                 440                 445             


Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu 
    450                 455                 460                 


Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln Asp 
465                 470                 475                 480 


Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg 
            500                 505                 510         


Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala Glu 
    530                 535                 540                 


Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp 
545                 550                 555                 560 


Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly Ile 
            580                 585                 590         


Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser 
    610                 615                 620                 


Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His 
625                 630                 635                 640 


Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val 
                645                 650                 655     


Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Ile Tyr Met Met 
            660                 665                 670         


Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met Ser 
        675                 680                 685             


Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg Gln 
    690                 695                 700                 


Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu Cys 
705                 710                 715                 720 


Val Pro Val Gln Phe Phe Gly Gly Trp Tyr Phe Tyr Ile Gln Ala Tyr 
                725                 730                 735     


Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val Leu 
            740                 745                 750         


Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Ile Ile Leu Leu Val Ala 
        755                 760                 765             


Met Tyr Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp Thr Pro 
    770                 775                 780                 


Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Ile 
785                 790                 795                 800 


Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu Gln 
                805                 810                 815     


Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu Leu 
            820                 825                 830         


Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile Ile 
        835                 840                 845             


Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile Glu 
    850                 855                 860                 


Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro 
865                 870                 875                 880 


Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Gln 
                885                 890                 895     


Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp Thr Thr 
            900                 905                 910         


Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys Ala 
        915                 920                 925             


Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro Phe 
    930                 935                 940                 


Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val Ile Gly 
945                 950                 955                 960 


Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr Asn Arg 
                965                 970                 975     


Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln Ala Ser 
            980                 985                 990         


Ile Thr Val Leu Cys Ile Ala Cys  Pro Cys Ser Leu Gly  Leu Ala Thr 
        995                 1000                 1005             


Pro Thr  Ala Val Met Val Gly  Thr Gly Val Gly Ala  Gln Asn Gly 
    1010                 1015                 1020             


Ile Leu  Ile Lys Gly Gly Glu  Pro Leu Glu Met Ala  His Lys Val 
    1025                 1030                 1035             


Lys Val  Val Val Phe Asp Lys  Thr Gly Thr Ile Thr  His Gly Thr 
    1040                 1045                 1050             


Pro Val  Val Asn Gln Val Lys  Val Leu Thr Glu Ser  Asn Arg Ile 
    1055                 1060                 1065             


Ser His  His Lys Ile Leu Ala  Ile Val Gly Thr Ala  Glu Ser Asn 
    1070                 1075                 1080             


Ser Glu  His Pro Leu Gly Thr  Ala Ile Thr Lys Tyr  Cys Lys Gln 
    1085                 1090                 1095             


Glu Leu  Asp Thr Glu Thr Leu  Gly Thr Cys Ile Asp  Phe Gln Val 
    1100                 1105                 1110             


Val Pro  Gly Cys Gly Ile Ser  Cys Lys Val Thr Asn  Ile Glu Gly 
    1115                 1120                 1125             


Leu Leu  His Lys Asn Asn Trp  Asn Ile Glu Asp Asn  Asn Ile Lys 
    1130                 1135                 1140             


Asn Ala  Ser Leu Val Gln Ile  Asp Ala Ser Asn Glu  Gln Ser Ser 
    1145                 1150                 1155             


Thr Ser  Ser Ser Met Ile Ile  Asp Ala Gln Ile Ser  Asn Ala Leu 
    1160                 1165                 1170             


Asn Ala  Gln Gln Tyr Lys Val  Leu Ile Gly Asn Arg  Glu Trp Met 
    1175                 1180                 1185             


Ile Arg  Asn Gly Leu Val Ile  Asn Asn Asp Val Asn  Asp Phe Met 
    1190                 1195                 1200             


Thr Glu  His Glu Arg Lys Gly  Arg Thr Ala Val Leu  Val Ala Val 
    1205                 1210                 1215             


Asp Asp  Glu Leu Cys Gly Leu  Ile Ala Ile Ala Asp  Thr Val Lys 
    1220                 1225                 1230             


Pro Glu  Ala Glu Leu Ala Ile  His Ile Leu Lys Ser  Met Gly Leu 
    1235                 1240                 1245             


Glu Val  Val Leu Met Thr Gly  Asp Asn Ser Lys Thr  Ala Arg Ser 
    1250                 1255                 1260             


Ile Ala  Ser Gln Val Gly Ile  Thr Lys Val Phe Ala  Glu Val Leu 
    1265                 1270                 1275             


Pro Ser  His Lys Val Ala Lys  Val Lys Gln Leu Gln  Glu Glu Gly 
    1280                 1285                 1290             


Lys Arg  Val Ala Met Val Gly  Asp Gly Ile Asn Asp  Ser Pro Ala 
    1295                 1300                 1305             


Leu Ala  Met Ala Asn Val Gly  Ile Ala Ile Gly Thr  Gly Thr Asp 
    1310                 1315                 1320             


Val Ala  Ile Glu Ala Ala Asp  Val Val Leu Ile Arg  Asn Asp Leu 
    1325                 1330                 1335             


Leu Asp  Val Val Ala Ser Ile  Asp Leu Ser Arg Glu  Thr Val Lys 
    1340                 1345                 1350             


Arg Ile  Arg Ile Asn Phe Val  Phe Ala Leu Ile Tyr  Asn Leu Val 
    1355                 1360                 1365             


Gly Ile  Pro Ile Ala Ala Gly  Val Phe Met Pro Ile  Gly Leu Val 
    1370                 1375                 1380             


Leu Gln  Pro Trp Met Gly Ser  Ala Ala Met Ala Ala  Ser Ser Val 
    1385                 1390                 1395             


Ser Val  Val Leu Ser Ser Leu  Phe Leu Lys Leu Tyr  Arg Lys Pro 
    1400                 1405                 1410             


Thr Tyr  Glu Ser Tyr Glu Leu  Pro Ala Arg Ser Gln  Ile Gly Gln 
    1415                 1420                 1425             


Lys Ser  Pro Ser Glu Ile Ser  Val His Val Gly Ile  Asp Asp Thr 
    1430                 1435                 1440             


Ser Arg  Asn Ser Pro Lys Leu  Gly Leu Leu Asp Arg  Ile Val Asn 
    1445                 1450                 1455             


Tyr Ser  Arg Ala Ser Ile Asn  Ser Leu Leu Ser Asp  Lys Arg Ser 
    1460                 1465                 1470             


Leu Asn  Ser Val Val Thr Ser  Glu Pro Asp Lys His  Ser Leu Leu 
    1475                 1480                 1485             


Val Gly  Asp Phe Arg Glu Asp  Asp Asp Thr Ala Leu  
    1490                 1495                 1500 


<210>  54
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Thr Ile Pro Glu Ile Pro Pro Lys Arg Gly Glu Leu 
        35                  40                  45              


Lys Thr Glu Leu Leu Gly Leu Lys Glu Arg Lys His Lys Pro Gln Val 
    50                  55                  60                  


Ser Gln Gln Glu Glu Leu Lys 
65                  70      


<210>  55
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala 
1               5                   10                  15      


Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu 
            20                  25                  30          


Leu Arg Ala Ala Pro Thr Ala Val His Pro Val Arg Asp Tyr Ala Ala 
        35                  40                  45              


Gln Thr Ser Pro Ser Pro Lys Ala Gly Ala Ala Thr Gly Arg Ile Val 
    50                  55                  60                  


Ala Val Ile Gly Ala Val Val Asp Val Gln Phe Asp Glu Gly Leu Pro 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Leu Glu Val Gln Gly Arg Glu Thr Arg Leu Val 
                85                  90                  95      


Leu Glu Val Ala Gln His Leu Gly Glu Ser Thr Val Arg Thr Ile Ala 
            100                 105                 110         


Met Asp Gly Thr Glu Gly Leu Val Arg Gly Gln Lys Val Leu Asp Ser 
        115                 120                 125             


Gly Ala Pro Ile Lys Ile Pro Val Gly Pro Glu Thr Leu Gly Arg Ile 
    130                 135                 140                 


Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile Lys Thr 
145                 150                 155                 160 


Lys Gln Phe Ala Pro Ile His Ala Glu Ala Pro Glu Phe Met Glu Met 
                165                 170                 175     


Ser Val Glu Gln Glu Ile Leu Val Thr Gly Ile Lys Val Val Asp Leu 
            180                 185                 190         


Leu Ala Pro Tyr Ala Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
        195                 200                 205             


Gly Val Gly Lys Thr Val Leu Ile Met Glu Leu Ile Asn Asn Val Ala 
    210                 215                 220                 


Lys Ala His Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
225                 230                 235                 240 


Arg Glu Gly Asn Asp Leu Tyr His Glu Met Ile Glu Ser Gly Val Ile 
                245                 250                 255     


Asn Leu Lys Asp Ala Thr Ser Lys Val Ala Leu Val Tyr Gly Gln Met 
            260                 265                 270         


Asn Glu Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr 
        275                 280                 285             


Val Ala Glu Tyr Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu Phe 
    290                 295                 300                 


Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala 
305                 310                 315                 320 


Leu Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala 
                325                 330                 335     


Thr Asp Met Gly Thr Met Gln Glu Arg Ile Thr Thr Thr Lys Lys Gly 
            340                 345                 350         


Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr 
        355                 360                 365             


Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala Thr Thr Val 
    370                 375                 380                 


Leu Ser Arg Ala Ile Ala Glu Leu Gly Ile Tyr Pro Ala Val Asp Pro 
385                 390                 395                 400 


Leu Asp Ser Thr Ser Arg Ile Met Asp Pro Asn Ile Val Gly Ser Glu 
                405                 410                 415     


His Tyr Asp Val Ala Arg Gly Val Gln Lys Ile Leu Gln Asp Tyr Lys 
            420                 425                 430         


Ser Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu 
        435                 440                 445             


Glu Asp Lys Leu Thr Val Ser Arg Ala Arg Lys Ile Gln Arg Phe Leu 
    450                 455                 460                 


Ser Gln Pro Phe Gln Val Ala Glu Val Phe Thr Gly His Met Gly Lys 
465                 470                 475                 480 


Leu Val Pro Leu Lys Glu Thr Ile Lys Gly Phe Gln Gln Ile Leu Ala 
                485                 490                 495     


Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Pro 
            500                 505                 510         


Ile Glu Glu Ala Val Ala Lys Ala Asp Lys Leu Ala Glu Glu His Ser 
        515                 520                 525             


Ser 
    


<210>  56
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ser His Arg Thr Ser Ser Thr Phe Arg Ala Glu Arg Ser Phe His 
1               5                   10                  15      


Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ser Ser Ser Ala Ser Arg 
            20                  25                  30          


Ala Leu Pro Ala Gln Asp Pro Pro Met Glu Lys Ala Leu Ser Met Phe 
        35                  40                  45              


Ser Asp Asp Phe Gly Ser Phe Met Arg Pro His Ser Glu Pro Leu Ala 
    50                  55                  60                  


Phe Pro Ala Arg Pro Gly Gly Ala Gly Asn Ile Lys Thr Leu Gly Asp 
65                  70                  75                  80  


Ala Tyr Glu Phe Ala Val Asp Val Arg Asp Phe Ser Pro Glu Asp Ile 
                85                  90                  95      


Ile Val Thr Thr Ser Asn Asn His Ile Glu Val Arg Ala Glu Lys Leu 
            100                 105                 110         


Ala Ala Asp Gly Thr Val Met Asn Thr Phe Ala His Lys Cys Gln Leu 
        115                 120                 125             


Pro Glu Asp Val Asp Pro Thr Ser Val Thr Ser Ala Leu Arg Glu Asp 
    130                 135                 140                 


Gly Ser Leu Thr Ile Arg Ala Arg Arg His Pro His Thr Glu His Val 
145                 150                 155                 160 


Gln Gln Thr Phe Arg Thr Glu Ile Lys Ile 
                165                 170 


<210>  57
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Asp Val Pro Gly Ala Gln Arg Ala Val Pro Gly Asp Gly Pro 
1               5                   10                  15      


Glu Pro Arg Asp Pro Leu Asp Cys Trp Ala Cys Ala Val Leu Val Thr 
            20                  25                  30          


Ala Gln Asn Leu Leu Val Ala Ala Phe Asn Leu Leu Leu Leu Val Leu 
        35                  40                  45              


Val Leu Gly Thr Ile Leu Leu Pro Ala Val Thr Met Leu Gly Phe Gly 
    50                  55                  60                  


Phe Leu Cys His Ser Gln Phe Leu Arg Ser Gln Ala Pro Pro Cys Thr 
65                  70                  75                  80  


Ala His Leu Arg Asp Pro Gly Phe Thr Ala Leu Leu Val Thr Gly Phe 
                85                  90                  95      


Leu Leu Leu Val Pro Leu Leu Val Leu Ala Leu Ala Ser Tyr Arg Arg 
            100                 105                 110         


Leu Cys Leu Arg Leu Arg Leu Ala Asp Cys Leu Val Pro Tyr Ser Arg 
        115                 120                 125             


Ala Leu Tyr Arg Arg Arg Arg Ala Pro Gln Pro Arg Gln Ile Arg Ala 
    130                 135                 140                 


Ser Pro Gly Ser Gln Ala Val Pro Thr Ser Gly Lys Val Trp Val 
145                 150                 155                 


<210>  58
<211>  1518
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Ala Val Gly Ser Gly Gly Tyr Ala Arg Asn Asp Ala Gly Glu 
1               5                   10                  15      


Lys Leu Pro Ser Val Met Ala Gly Val Pro Ala Arg Arg Gly Gln Ser 
            20                  25                  30          


Ser Pro Pro Pro Ala Pro Pro Ile Cys Leu Arg Arg Arg Thr Arg Leu 
        35                  40                  45              


Ser Thr Ala Ser Glu Glu Thr Val Gln Asn Arg Val Ser Leu Glu Lys 
    50                  55                  60                  


Val Leu Gly Ile Thr Ala Gln Asn Ser Ser Gly Leu Thr Cys Asp Pro 
65                  70                  75                  80  


Gly Thr Gly His Val Ala Tyr Leu Ala Gly Cys Val Val Val Ile Leu 
                85                  90                  95      


Asp Pro Lys Glu Asn Lys Gln Gln His Ile Phe Asn Thr Ala Arg Lys 
            100                 105                 110         


Ser Leu Ser Ala Leu Ala Phe Ser Pro Asp Gly Lys Tyr Ile Val Thr 
        115                 120                 125             


Gly Glu Asn Gly His Arg Pro Ala Val Arg Ile Trp Asp Val Glu Glu 
    130                 135                 140                 


Lys Asn Gln Val Ala Glu Met Leu Gly His Lys Tyr Gly Val Ala Cys 
145                 150                 155                 160 


Val Ala Phe Ser Pro Asn Met Lys His Ile Val Ser Met Gly Tyr Gln 
                165                 170                 175     


His Asp Met Val Leu Asn Val Trp Asp Trp Lys Lys Asp Ile Val Val 
            180                 185                 190         


Ala Ser Asn Lys Val Ser Cys Arg Val Ile Ala Leu Ser Phe Ser Glu 
        195                 200                 205             


Asp Ser Ser Tyr Phe Val Thr Val Gly Asn Arg His Val Arg Phe Trp 
    210                 215                 220                 


Phe Leu Glu Val Ser Thr Glu Thr Lys Val Thr Ser Thr Val Pro Leu 
225                 230                 235                 240 


Val Gly Arg Ser Gly Ile Leu Gly Glu Leu His Asn Asn Ile Phe Cys 
                245                 250                 255     


Gly Val Ala Cys Gly Arg Gly Arg Met Ala Gly Ser Thr Phe Cys Val 
            260                 265                 270         


Ser Tyr Ser Gly Leu Leu Cys Gln Phe Asn Glu Lys Arg Val Leu Glu 
        275                 280                 285             


Lys Trp Ile Asn Leu Lys Val Ser Leu Ser Ser Cys Leu Cys Val Ser 
    290                 295                 300                 


Gln Glu Leu Ile Phe Cys Gly Cys Thr Asp Gly Ile Val Arg Ile Phe 
305                 310                 315                 320 


Gln Ala His Ser Leu His Tyr Leu Ala Asn Leu Pro Lys Pro His Tyr 
                325                 330                 335     


Leu Gly Val Asp Val Ala Gln Gly Leu Glu Pro Ser Phe Leu Phe His 
            340                 345                 350         


Arg Lys Ala Glu Ala Val Tyr Pro Asp Thr Val Ala Leu Thr Phe Asp 
        355                 360                 365             


Pro Ile His Gln Trp Leu Ser Cys Val Tyr Lys Asp His Ser Ile Tyr 
    370                 375                 380                 


Ile Trp Asp Val Lys Asp Ile Asn Arg Val Gly Lys Val Trp Ser Glu 
385                 390                 395                 400 


Leu Phe His Ser Ser Tyr Val Trp Asn Val Glu Val Tyr Pro Glu Phe 
                405                 410                 415     


Glu Asp Gln Arg Ala Cys Leu Pro Ser Gly Ser Phe Leu Thr Cys Ser 
            420                 425                 430         


Ser Asp Asn Thr Ile Arg Phe Trp Asn Leu Asp Ser Ser Pro Asp Ser 
        435                 440                 445             


His Trp Gln Lys Asn Ile Phe Ser Asn Thr Leu Leu Lys Val Val Tyr 
    450                 455                 460                 


Val Glu Asn Asp Ile Gln His Leu Gln Asp Met Ser His Phe Pro Asp 
465                 470                 475                 480 


Arg Gly Ser Glu Asn Gly Thr Pro Met Asp Val Lys Ala Gly Val Arg 
                485                 490                 495     


Val Met Gln Val Ser Pro Asp Gly Gln His Leu Ala Ser Gly Asp Arg 
            500                 505                 510         


Ser Gly Asn Leu Arg Ile His Glu Leu His Phe Met Asp Glu Leu Val 
        515                 520                 525             


Lys Val Glu Ala His Asp Ala Glu Val Leu Cys Leu Glu Tyr Ser Lys 
    530                 535                 540                 


Pro Glu Thr Gly Leu Thr Leu Leu Ala Ser Ala Ser Arg Asp Arg Leu 
545                 550                 555                 560 


Ile His Val Leu Asn Val Glu Lys Asn Tyr Asn Leu Glu Gln Thr Leu 
                565                 570                 575     


Asp Asp His Ser Ser Ser Ile Thr Ala Ile Lys Phe Ala Gly Asn Arg 
            580                 585                 590         


Asp Ile Gln Met Ile Ser Cys Gly Ala Asp Lys Ser Ile Tyr Phe Arg 
        595                 600                 605             


Ser Ala Gln Gln Gly Ser Asp Gly Leu His Phe Val Arg Thr His His 
    610                 615                 620                 


Val Ala Glu Lys Thr Thr Leu Tyr Asp Met Asp Ile Asp Ile Thr Gln 
625                 630                 635                 640 


Lys Tyr Val Ala Val Ala Cys Gln Asp Arg Asn Val Arg Val Tyr Asn 
                645                 650                 655     


Thr Val Asn Gly Lys Gln Lys Lys Cys Tyr Lys Gly Ser Gln Gly Asp 
            660                 665                 670         


Glu Gly Ser Leu Leu Lys Val His Val Asp Pro Ser Gly Thr Phe Leu 
        675                 680                 685             


Ala Thr Ser Cys Ser Asp Lys Ser Ile Ser Val Ile Asp Phe Tyr Ser 
    690                 695                 700                 


Gly Glu Cys Ile Ala Lys Met Phe Gly His Ser Glu Ile Ile Thr Ser 
705                 710                 715                 720 


Met Lys Phe Thr Tyr Asp Cys His His Leu Ile Thr Val Ser Gly Asp 
                725                 730                 735     


Ser Cys Val Phe Ile Trp His Leu Gly Pro Glu Ile Thr Asn Cys Met 
            740                 745                 750         


Lys Gln His Leu Leu Glu Ile Asp His Arg Gln Gln Gln Gln His Thr 
        755                 760                 765             


Asn Asp Lys Lys Arg Ser Gly His Pro Arg Gln Asp Thr Tyr Val Ser 
    770                 775                 780                 


Thr Pro Ser Glu Ile His Ser Leu Ser Pro Gly Glu Gln Thr Glu Asp 
785                 790                 795                 800 


Asp Leu Glu Glu Glu Cys Glu Pro Glu Glu Met Leu Lys Thr Pro Ser 
                805                 810                 815     


Lys Asp Ser Leu Asp Pro Asp Pro Arg Cys Leu Leu Thr Asn Gly Lys 
            820                 825                 830         


Leu Pro Leu Trp Ala Lys Arg Leu Leu Gly Asp Asp Asp Val Ala Asp 
        835                 840                 845             


Gly Leu Ala Phe His Ala Lys Arg Ser Tyr Gln Pro His Gly Arg Trp 
    850                 855                 860                 


Ala Glu Arg Ala Gly Gln Glu Pro Leu Lys Thr Ile Leu Asp Ala Gln 
865                 870                 875                 880 


Asp Leu Asp Cys Tyr Phe Thr Pro Met Lys Pro Glu Ser Leu Glu Asn 
                885                 890                 895     


Ser Ile Leu Asp Ser Leu Glu Pro Gln Ser Leu Ala Ser Leu Leu Ser 
            900                 905                 910         


Glu Ser Glu Ser Pro Gln Glu Ala Gly Arg Gly His Pro Ser Phe Leu 
        915                 920                 925             


Pro Gln Gln Lys Glu Ser Ser Glu Ala Ser Glu Leu Ile Leu Tyr Ser 
    930                 935                 940                 


Leu Glu Ala Glu Val Thr Val Thr Gly Thr Asp Ser Gln Tyr Cys Arg 
945                 950                 955                 960 


Lys Glu Val Glu Ala Gly Pro Gly Asp Gln Gln Gly Asp Ser Tyr Leu 
                965                 970                 975     


Arg Val Ser Ser Asp Ser Pro Lys Asp Gln Ser Pro Pro Glu Asp Ser 
            980                 985                 990         


Gly Glu Ser Glu Ala Asp Leu Glu  Cys Ser Phe Ala Ala  Ile His Ser 
        995                 1000                 1005             


Pro Ala  Pro Pro Pro Asp Pro  Ala Pro Arg Phe Ala  Thr Ser Leu 
    1010                 1015                 1020             


Pro His  Phe Pro Gly Cys Ala  Gly Pro Thr Glu Asp  Glu Leu Ser 
    1025                 1030                 1035             


Leu Pro  Glu Gly Pro Ser Val  Pro Ser Ser Ser Leu  Pro Gln Thr 
    1040                 1045                 1050             


Pro Glu  Gln Glu Lys Phe Leu  Arg His His Phe Glu  Thr Leu Thr 
    1055                 1060                 1065             


Glu Ser  Pro Cys Arg Ala Leu  Gly Asp Val Glu Ala  Ser Glu Ala 
    1070                 1075                 1080             


Glu Asp  His Phe Phe Asn Pro  Arg Leu Ser Ile Ser  Thr Gln Phe 
    1085                 1090                 1095             


Leu Ser  Ser Leu Gln Lys Ala  Ser Arg Phe Thr His  Thr Phe Pro 
    1100                 1105                 1110             


Pro Arg  Ala Thr Gln Cys Leu  Val Lys Ser Pro Glu  Val Lys Leu 
    1115                 1120                 1125             


Met Asp  Arg Gly Gly Ser Gln  Pro Arg Ala Gly Thr  Gly Tyr Ala 
    1130                 1135                 1140             


Ser Pro  Asp Arg Thr His Val  Leu Ala Ala Gly Lys  Ala Glu Glu 
    1145                 1150                 1155             


Thr Leu  Glu Ala Trp Arg Pro  Pro Pro Pro Cys Leu  Thr Ser Leu 
    1160                 1165                 1170             


Ala Ser  Cys Val Pro Ala Ser  Ser Val Leu Pro Thr  Asp Arg Asn 
    1175                 1180                 1185             


Leu Pro  Thr Pro Thr Ser Ala  Pro Thr Pro Gly Leu  Ala Gln Gly 
    1190                 1195                 1200             


Val His  Ala Pro Ser Thr Cys  Ser Tyr Met Glu Ala  Thr Ala Ser 
    1205                 1210                 1215             


Ser Arg  Ala Arg Ile Ser Arg  Ser Ile Ser Leu Gly  Asp Ser Glu 
    1220                 1225                 1230             


Gly Pro  Ile Val Ala Thr Leu  Ala Gln Pro Leu Arg  Arg Pro Ser 
    1235                 1240                 1245             


Ser Val  Gly Glu Leu Ala Ser  Leu Gly Gln Glu Leu  Gln Ala Ile 
    1250                 1255                 1260             


Thr Thr  Ala Thr Thr Pro Ser  Leu Asp Ser Glu Gly  Gln Glu Pro 
    1265                 1270                 1275             


Ala Leu  Arg Ser Trp Gly Asn  His Glu Ala Arg Ala  Asn Leu Arg 
    1280                 1285                 1290             


Leu Thr  Leu Ser Ser Ala Cys  Asp Gly Leu Leu Gln  Pro Pro Val 
    1295                 1300                 1305             


Asp Thr  Gln Pro Gly Val Thr  Val Pro Ala Val Ser  Phe Pro Ala 
    1310                 1315                 1320             


Pro Ser  Pro Val Glu Glu Ser  Ala Leu Arg Leu His  Gly Ser Ala 
    1325                 1330                 1335             


Phe Arg  Pro Ser Leu Pro Ala  Pro Glu Ser Pro Gly  Leu Pro Ala 
    1340                 1345                 1350             


His Pro  Ser Asn Pro Gln Leu  Pro Glu Ala Arg Pro  Gly Ile Pro 
    1355                 1360                 1365             


Gly Gly  Thr Ala Ser Leu Leu  Glu Pro Thr Ser Gly  Ala Leu Gly 
    1370                 1375                 1380             


Leu Leu  Gln Gly Ser Pro Ala  Arg Trp Ser Glu Pro  Trp Val Pro 
    1385                 1390                 1395             


Val Glu  Ala Leu Pro Pro Ser  Pro Leu Glu Leu Ser  Arg Val Gly 
    1400                 1405                 1410             


Asn Ile  Leu His Arg Leu Gln  Thr Thr Phe Gln Glu  Ala Leu Asp 
    1415                 1420                 1425             


Leu Tyr  Arg Val Leu Val Ser  Ser Gly Gln Val Asp  Thr Gly Gln 
    1430                 1435                 1440             


Gln Gln  Ala Arg Thr Glu Leu  Val Ser Thr Phe Leu  Trp Ile His 
    1445                 1450                 1455             


Ser Gln  Leu Glu Ala Glu Cys  Leu Val Gly Thr Ser  Val Ala Pro 
    1460                 1465                 1470             


Ala Gln  Ala Leu Pro Ser Pro  Gly Pro Pro Ser Pro  Pro Thr Leu 
    1475                 1480                 1485             


Tyr Pro  Leu Ala Ser Pro Asp  Leu Gln Ala Leu Leu  Glu His Tyr 
    1490                 1495                 1500             


Ser Glu  Leu Leu Val Gln Ala  Val Arg Arg Lys Ala  Arg Gly His 
    1505                 1510                 1515             


<210>  59
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Met Met Val Met Gln Pro Glu Gly Leu Gly Ala Gly Glu Gly Arg 
1               5                   10                  15      


Phe Ala Gly Gly Gly Gly Gly Gly Glu Tyr Met Glu Gln Glu Glu Asp 
            20                  25                  30          


Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln Gln Arg 
        35                  40                  45              


Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu Arg Lys Ala Gly Thr 
    50                  55                  60                  


Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asn Gly Leu Lys Leu Met 
65                  70                  75                  80  


Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Pro Arg Pro Asp Lys 
                85                  90                  95      


Gly Lys Met Arg Phe His Lys Ile Ala Asn Val Asn Lys Ala Leu Asp 
            100                 105                 110         


Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala Glu Glu 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Met Thr Leu Gly Met Ile Trp Thr Ile 
    130                 135                 140                 


Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Thr Ser Ala 
145                 150                 155                 160 


Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Thr Ala Pro Tyr Arg 
                165                 170                 175     


Asn Val Asn Val Gln Asn Phe His Thr Ser Trp Lys Asp Gly Leu Ala 
            180                 185                 190         


Leu Cys Ala Leu Ile His Arg His Arg Pro Asp Leu Ile Asp Tyr Ala 
        195                 200                 205             


Lys Leu Arg Lys Asp Asp Pro Ile Gly Asn Leu Asn Thr Ala Phe Glu 
    210                 215                 220                 


Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala Glu Asp 
225                 230                 235                 240 


Ile Val Asn Thr Pro Lys Pro Asp Glu Lys Ala Ile Met Thr Tyr Val 
                245                 250                 255     


Ser Cys Phe Tyr His Ala Phe Ala Gly Ala Glu Gln Ala Glu Thr Ala 
            260                 265                 270         


Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn Glu Lys 
        275                 280                 285             


Leu Met Glu Glu Tyr Glu Lys Leu Ala Ser Glu Leu Leu Glu Trp Ile 
    290                 295                 300                 


Arg Arg Thr Val Pro Trp Leu Glu Asn Arg Val Gly Glu Pro Ser Met 
305                 310                 315                 320 


Ser Ala Met Gln Arg Lys Leu Glu Asp Phe Arg Asp Tyr Arg Arg Leu 
                325                 330                 335     


His Lys Pro Pro Arg Ile Gln Glu Lys Cys Gln Leu Glu Ile Asn Phe 
            340                 345                 350         


Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser His Arg Pro Ala Phe Met 
        355                 360                 365             


Pro Ser Glu Gly Lys Leu Val Ser Asp Ile Ala Asn Ala Trp Arg Gly 
    370                 375                 380                 


Leu Glu Gln Val Glu Lys Gly Tyr Glu Asp Trp Leu Leu Ser Glu Ile 
385                 390                 395                 400 


Arg Arg Leu Gln Arg Leu Gln His Leu Ala Glu Lys Phe Arg Gln Lys 
                405                 410                 415     


Ala Ser Leu His Glu Ala Trp Thr Arg Gly Lys Glu Glu Met Leu Ser 
            420                 425                 430         


Gln Arg Asp Tyr Asp Ser Ala Leu Leu Gln Glu Val Arg Ala Leu Leu 
        435                 440                 445             


Arg Arg His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln Asp Arg 
    450                 455                 460                 


Val Glu His Ile Ala Ala Leu Ala Gln Glu Leu Asn Glu Leu Asp Tyr 
465                 470                 475                 480 


His Glu Ala Ala Ser Val Asn Ser Arg Cys Gln Ala Ile Cys Asp Gln 
                485                 490                 495     


Trp Asp Asn Leu Gly Thr Leu Thr Gln Lys Arg Arg Asp Ala Leu Glu 
            500                 505                 510         


Arg Met Glu Lys Leu Leu Glu Thr Ile Asp Arg Leu Gln Leu Glu Phe 
        515                 520                 525             


Ala Arg Arg Ala Ala Pro Phe Asn Asn Trp Leu Asp Gly Ala Val Glu 
    530                 535                 540                 


Asp Leu Gln Asp Val Trp Leu Val His Ser Val Glu Glu Thr Gln Ser 
545                 550                 555                 560 


Leu Leu Thr Ala His Asp Gln Phe Lys Ala Thr Leu Pro Glu Ala Asp 
                565                 570                 575     


Arg Glu Arg Gly Ala Ile Met Gly Ile Gln Gly Glu Ile Gln Lys Ile 
            580                 585                 590         


Cys Gln Thr Tyr Gly Leu Arg Pro Cys Ser Thr Asn Pro Tyr Ile Thr 
        595                 600                 605             


Leu Ser Pro Gln Asp Ile Asn Thr Lys Trp Asp Met Val Arg Lys Leu 
    610                 615                 620                 


Val Pro Ser Cys Asp Gln Thr Leu Gln Glu Glu Leu Ala Arg Gln Gln 
625                 630                 635                 640 


Val Asn Glu Arg Leu Arg Arg Gln Phe Ala Ala Gln Ala Asn Ala Ile 
                645                 650                 655     


Gly Pro Trp Ile Gln Ala Lys Val Glu Glu Val Gly Arg Leu Ala Ala 
            660                 665                 670         


Gly Leu Ala Gly Ser Leu Glu Glu Gln Met Ala Gly Leu Arg Gln Gln 
        675                 680                 685             


Glu Gln Asn Ile Ile Asn Tyr Lys Thr Asn Ile Asp Arg Leu Glu Gly 
    690                 695                 700                 


Asp His Gln Leu Leu Gln Glu Ser Leu Val Phe Asp Asn Lys His Thr 
705                 710                 715                 720 


Val Tyr Ser Met Glu His Ile Arg Val Gly Trp Glu Gln Leu Leu Thr 
                725                 730                 735     


Ser Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Val Leu Thr Arg 
            740                 745                 750         


Asp Ala Lys Gly Leu Ser Gln Glu Gln Leu Asn Glu Phe Arg Ala Ser 
        755                 760                 765             


Phe Asn His Phe Asp Arg Lys Gln Asn Gly Met Met Glu Pro Asp Asp 
    770                 775                 780                 


Phe Arg Ala Cys Leu Ile Ser Met Gly Tyr Asp Leu Gly Glu Val Glu 
785                 790                 795                 800 


Phe Ala Arg Ile Met Thr Met Val Asp Pro Asn Ala Ala Gly Val Val 
                805                 810                 815     


Thr Phe Gln Ala Phe Ile Asp Phe Met Thr Arg Glu Thr Ala Glu Thr 
            820                 825                 830         


Asp Thr Thr Glu Gln Val Val Ala Ser Phe Lys Ile Leu Ala Gly Asp 
        835                 840                 845             


Lys Asn Tyr Ile Thr Pro Glu Glu Leu Arg Arg Glu Leu Pro Ala Lys 
    850                 855                 860                 


Gln Ala Glu Tyr Cys Ile Arg Arg Met Val Pro Tyr Lys Gly Ser Gly 
865                 870                 875                 880 


Ala Pro Ala Gly Ala Leu Asp Tyr Val Ala Phe Ser Ser Ala Leu Tyr 
                885                 890                 895     


Gly Glu Ser Asp Leu 
            900     


<210>  60
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  61
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15      


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30          


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45              


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60                  


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80  


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95      


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110         


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125             


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140                 


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160 


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175     


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190         


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205             


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220                 


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240 


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255     


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270         


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285             


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300                 


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320 


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335     


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350         


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365             


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380                 


Val Ile Gln Tyr Pro Gln Phe Phe Gly His Ser Tyr Val Thr Phe Glu 
385                 390                 395                 400 


Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln Ile Thr Leu Glu Phe Arg 
                405                 410                 415     


Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr Cys Gly Glu Asn Glu His 
            420                 425                 430         


Gly Arg Gly Asp Phe Met Ser Leu Ala Ile Ile Arg Arg Ser Leu Gln 
        435                 440                 445             


Phe Arg Phe Asn Cys Gly Thr Gly Val Ala Ile Ile Val Ser Glu Thr 
    450                 455                 460                 


Lys Ile Lys Leu Gly Gly Trp His Thr Val Met Leu Tyr Arg Asp Gly 
465                 470                 475                 480 


Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly Thr Pro Val Thr Gly Gln 
                485                 490                 495     


Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe Arg Thr Pro Leu Tyr Leu 
            500                 505                 510         


Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val Arg Ala Thr Gly Thr Asn 
        515                 520                 525             


Arg Gly Phe Gln Gly Cys Val Gln Ser Leu Ala Val Asn Gly Arg Arg 
    530                 535                 540                 


Ile Asp Met Arg Pro Trp Pro Leu Gly Lys Ala Leu Ser Gly Ala Asp 
545                 550                 555                 560 


Val Gly Glu Cys Ser Ser Gly Ile Cys Asp Glu Ala Ser Cys Ile His 
                565                 570                 575     


Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp Ser Tyr Ile Cys Leu Cys 
            580                 585                 590         


Pro Leu Gly Phe Lys Gly Arg His Cys Glu Asp Ala Phe Thr Leu Thr 
        595                 600                 605             


Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser Tyr Ala Ala Thr Pro Trp 
    610                 615                 620                 


Pro Leu Glu Pro Gln His Tyr Leu Ser Phe Met Glu Phe Glu Ile Thr 
625                 630                 635                 640 


Phe Arg Pro Asp Ser Gly Asp Gly Val Leu Leu Tyr Ser Tyr Asp Thr 
                645                 650                 655     


Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu Ala Gly Gly His Val Glu 
            660                 665                 670         


Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly Val Leu Arg Ser Glu Asp 
        675                 680                 685             


Pro Leu Thr Leu Gly Asn Trp His Glu Leu Arg Val Ser Arg Thr Ala 
    690                 695                 700                 


Lys Asn Gly Ile Leu Gln Val Asp Lys Gln Lys Ile Val Glu Gly Met 
705                 710                 715                 720 


Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys Asn Thr Asp Ile Phe Ile 
                725                 730                 735     


Gly Gly Val Pro Asn Tyr Asp Asp Val Lys Lys Asn Ser Gly Val Leu 
            740                 745                 750         


Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile Ile Leu Asn Asp Arg Thr 
        755                 760                 765             


Ile His Val Lys His Asp Phe Thr Ser Gly Val Asn Val Glu Asn Ala 
    770                 775                 780                 


Ala His Pro Cys Val Arg Ala Pro Cys Ala His Gly Gly Ser Cys Arg 
785                 790                 795                 800 


Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys Pro Leu Gly Phe Glu Gly 
                805                 810                 815     


Leu His Cys Gln Lys Glu Cys Gly Asn Tyr Cys Leu Asn Thr Ile Ile 
            820                 825                 830         


Glu Ala Ile Glu Ile Pro Gln Phe Ile Gly Arg Ser Tyr Leu Thr Tyr 
        835                 840                 845             


Asp Asn Pro Asp Ile Leu Lys Arg Val Ser Gly Ser Arg Ser Asn Val 
    850                 855                 860                 


Phe Met Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg 
865                 870                 875                 880 


Gly Asp Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu 
                885                 890                 895     


Arg Asp Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala 
            900                 905                 910         


Ser Ile Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val 
        915                 920                 925             


Lys Ala Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr 
    930                 935                 940                 


Gly Ala Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile 
945                 950                 955                 960 


Asn Gly Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr 
                965                 970                 975     


Asn Arg Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr 
            980                 985                 990         


Leu Ser Thr Asp Tyr His Ile Ser  Leu Val Glu Asp Ala  Val Asp Gly 
        995                 1000                 1005             


Lys Asn  Ile Asn Thr Cys Gly  Ala Lys 
    1010                 1015         


<210>  62
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Thr Glu Asn Val Val Cys Thr Gly Ala Val Asn Ala Val Lys Glu 
1               5                   10                  15      


Val Trp Glu Lys Arg Ile Lys Lys Leu Asn Glu Asp Leu Lys Arg Glu 
            20                  25                  30          


Lys Glu Phe Gln His Lys Leu Val Arg Ile Trp Glu Glu Arg Val Ser 
        35                  40                  45              


Leu Thr Lys Leu Arg Glu Lys Val Thr Arg Glu Asp Gly Arg Val Ile 
    50                  55                  60                  


Leu Lys Ile Glu Lys Glu Glu Trp Lys Thr Leu Pro Ser Ser Leu Leu 
65                  70                  75                  80  


Lys Leu Asn Gln Leu Gln Glu Trp Gln Leu His Arg Thr Gly Leu Leu 
                85                  90                  95      


Lys Ile Pro Glu Phe Ile Gly Arg Phe Gln Asn Leu Ile Val Leu Asp 
            100                 105                 110         


Leu Ser Arg Asn Thr Ile Ser Glu Ile Pro Pro Gly Ile Gly Leu Leu 
        115                 120                 125             


Thr Arg Leu Gln Glu Leu Ile Leu Ser Tyr Asn Lys Ile Lys Thr Val 
    130                 135                 140                 


Pro Lys Glu Leu Ser Asn Cys Ala Ser Leu Glu Lys Leu Glu Leu Ala 
145                 150                 155                 160 


Val Asn Arg Asp Ile Cys Asp Leu Pro Gln Glu Leu Ser Asn Leu Leu 
                165                 170                 175     


Lys Leu Thr His Leu Asp Leu Ser Met Asn Asp Phe Thr Thr Ile Pro 
            180                 185                 190         


Leu Ala Val Leu Asn Met Pro Ala Leu Glu Trp Leu Asp Met Gly Ser 
        195                 200                 205             


Asn Lys Leu Glu Gln Leu Pro Asp Thr Ile Glu Arg Met Gln Asn Leu 
    210                 215                 220                 


His Thr Leu Trp Leu Gln Arg Asn Glu Ile Thr Cys Leu Pro Gln Thr 
225                 230                 235                 240 


Ile Ser Asn Met Lys Asn Leu Gly Thr Leu Val Leu Ser Asn Asn Lys 
                245                 250                 255     


Leu Gln Asp Ile Pro Val Cys Met Glu Glu Met Ala Asn Leu Arg Phe 
            260                 265                 270         


Val Asn Phe Arg Asp Asn Pro Leu Lys Leu Lys Val Ser Leu Pro Pro 
        275                 280                 285             


Ser Glu Gly Thr Asp Glu Glu Glu Glu Arg Glu Leu Phe Gly Leu Gln 
    290                 295                 300                 


Phe Met His Thr Tyr Ile Gln Glu Ser Arg Arg Arg Ala Asp His Gln 
305                 310                 315                 320 


Val Asn Gly Ser Thr Thr Leu Pro Ile Ser Ile Asn Thr Asp Gly 
                325                 330                 335 


<210>  63
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ser Phe Gln Gly Lys Lys Ser Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Arg Gly Gly Arg Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Val His Val Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Ile Lys Thr Ile Asp Ala His Gly Leu Met 
    50                  55                  60                  


Val Leu Pro Gly Gly Val Asp Val His Thr Arg Leu Gln Met Pro Val 
65                  70                  75                  80  


Leu Gly Met Thr Pro Ala Asp Asp Phe Cys Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Leu Asp His Val Phe Pro Asp Thr 
            100                 105                 110         


Gly Val Ser Leu Leu Ala Ala Tyr Glu Gln Trp Arg Glu Arg Ala Asp 
        115                 120                 125             


Ser Ala Ala Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Arg Trp 
    130                 135                 140                 


His Glu Ser Ile Lys Glu Glu Leu Glu Ala Leu Val Lys Glu Lys Gly 
145                 150                 155                 160 


Val Asn Ser Phe Leu Val Phe Met Ala Tyr Lys Asp Arg Cys Gln Cys 
                165                 170                 175     


Ser Asp Ser Gln Met Tyr Glu Ile Phe Ser Ile Ile Arg Asp Leu Gly 
            180                 185                 190         


Ala Leu Ala Gln Val His Ala Glu Asn Gly Asp Ile Val Glu Glu Glu 
        195                 200                 205             


Gln Lys Arg Leu Leu Glu Leu Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser His Pro Glu Glu Val Glu Ala Glu Ala Val Tyr Arg Ala Val 
225                 230                 235                 240 


Thr Ile Ala Lys Gln Ala Asn Cys Pro Leu Tyr Val Thr Lys Val Met 
                245                 250                 255     


Ser Lys Gly Ala Ala Asp Ala Ile Ala Gln Ala Lys Arg Arg Gly Val 
            260                 265                 270         


Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Val Asn Pro Asp Pro Thr Thr Ala Asp His Leu Thr Cys Leu 
305                 310                 315                 320 


Leu Ser Ser Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Thr Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Ala Leu Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Ile Glu Glu Arg Met Ser Met Val Trp Glu Lys 
        355                 360                 365             


Cys Val Ala Ser Gly Lys Met Asp Glu Asn Glu Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Ile Phe Asn Phe Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Val Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asn Pro Lys Ala 
                405                 410                 415     


Thr Lys Ile Ile Ser Ala Lys Thr His Asn Leu Asn Val Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Val Glu Cys Arg Gly Ala Pro Ala Val Val Ile Ser 
        435                 440                 445             


Gln Gly Arg Val Ala Leu Glu Asp Gly Lys Met Phe Val Thr Pro Gly 
    450                 455                 460                 


Ala Gly Arg Phe Val Pro Arg Lys Thr Phe Pro Asp Phe Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Asn Arg Leu Ala Glu Ile His Gly Val Pro Arg 
                485                 490                 495     


Gly Leu Tyr Asp Gly Pro Val His Glu Val Met Val Pro Ala Lys Pro 
            500                 505                 510         


Gly Ser Gly Ala Pro Ala Arg Ala Ser Cys Pro Gly Lys Ile Ser Val 
        515                 520                 525             


Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ser 
    530                 535                 540                 


Gln Ala Asp Asp His Ile Ala Arg Arg Thr Ala Gln Lys Ile Met Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
                565                 570         


<210>  64
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ser Gly Ala Ser Ser Ser Glu Gln Asn Asn Asn Ser Tyr Glu Thr 
1               5                   10                  15      


Lys Thr Pro Asn Leu Arg Met Ser Glu Lys Lys Cys Ser Trp Ala Ser 
            20                  25                  30          


Tyr Met Thr Asn Ser Pro Thr Leu Ile Val Met Ile Gly Leu Pro Ala 
        35                  40                  45              


Arg Gly Lys Thr Tyr Val Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp 
    50                  55                  60                  


Ile Gly Val Pro Thr Lys Val Phe Asn Leu Gly Val Tyr Arg Arg Glu 
65                  70                  75                  80  


Ala Val Lys Ser Tyr Lys Ser Tyr Asp Phe Phe Arg His Asp Asn Glu 
                85                  90                  95      


Glu Ala Met Lys Ile Arg Lys Gln Cys Ala Leu Val Ala Leu Glu Asp 
            100                 105                 110         


Val Lys Ala Tyr Leu Thr Glu Glu Asn Gly Gln Ile Ala Val Phe Asp 
        115                 120                 125             


Ala Thr Asn Thr Thr Arg Glu Arg Arg Asp Met Ile Leu Asn Phe Ala 
    130                 135                 140                 


Glu Gln Asn Ser Phe Lys Val Phe Phe Val Glu Ser Val Cys Asp Asp 
145                 150                 155                 160 


Pro Asp Val Ile Ala Ala Asn Ile Leu Glu Val Lys Val Ser Ser Pro 
                165                 170                 175     


Asp Tyr Pro Glu Arg Asn Arg Glu Asn Val Met Glu Asp Phe Leu Lys 
            180                 185                 190         


Arg Ile Glu Cys Tyr Lys Val Thr Tyr Arg Pro Leu Asp Pro Asp Asn 
        195                 200                 205             


Tyr Asp Lys Asp Leu Ser Phe Ile Lys Val Ile Asn Val Gly Gln Arg 
    210                 215                 220                 


Phe Leu Val Asn Arg Val Gln Asp Tyr Ile Gln Ser Lys Ile Val Tyr 
225                 230                 235                 240 


Tyr Leu Met Asn Ile His Val Gln Pro Arg Thr Ile Tyr Leu Cys Arg 
                245                 250                 255     


His Gly Glu Ser Glu Phe Asn Leu Leu Gly Lys Ile Gly Gly Asp Ser 
            260                 265                 270         


Gly Leu Ser Val Arg Gly Lys Gln Phe Ala Gln Ala Leu Arg Lys Phe 
        275                 280                 285             


Leu Glu Glu Gln Glu Ile Thr Asp Leu Lys Val Trp Thr Ser Gln Leu 
    290                 295                 300                 


Lys Arg Thr Ile Gln Thr Ala Glu Ser Leu Gly Val Pro Tyr Glu Gln 
305                 310                 315                 320 


Trp Lys Ile Leu Asn Glu Ile Asp Ala Gly Val Cys Glu Glu Met Thr 
                325                 330                 335     


Tyr Ala Glu Ile Glu Lys Arg Tyr Pro Glu Glu Phe Ala Leu Arg Asp 
            340                 345                 350         


Gln Glu Lys Tyr Leu Tyr Arg Tyr Pro Gly Gly Glu Ser Tyr Gln Asp 
        355                 360                 365             


Leu Val Gln Arg Leu Glu Pro Val Ile Met Glu Leu Glu Arg Gln Gly 
    370                 375                 380                 


Asn Val Leu Val Ile Ser His Gln Ala Val Met Arg Cys Leu Leu Ala 
385                 390                 395                 400 


Tyr Phe Leu Asp Lys Gly Ala Asp Glu Leu Pro Tyr Leu Arg Cys Pro 
                405                 410                 415     


Leu His Thr Ile Phe Lys Leu Thr Pro Val Ala Tyr Gly Cys Lys Val 
            420                 425                 430         


Glu Thr Ile Lys Leu Asn Val Glu Ala Val Asn Thr His Arg Asp Lys 
        435                 440                 445             


Pro Thr Asn Asn Phe Pro Lys Asn Gln Thr Pro Val Arg Met Arg Arg 
    450                 455                 460                 


Asn Ser Phe Thr Pro Leu Ser Ser Ser Asn Thr Ile Arg Arg Pro Arg 
465                 470                 475                 480 


Asn Tyr Ser Val Gly Ser Arg Pro Leu Lys Pro Leu Ser Pro Leu Arg 
                485                 490                 495     


Ala Gln Asp Met Gln Glu Gly Ala Asp 
            500                 505 


<210>  65
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Val Thr Val Gly Asn Tyr Cys Glu Ala Glu Gly Pro Val Gly Pro 
1               5                   10                  15      


Ala Trp Met Gln Asp Gly Leu Ser Pro Cys Phe Phe Phe Thr Leu Val 
            20                  25                  30          


Pro Ser Thr Arg Met Ala Leu Gly Thr Leu Ala Leu Val Leu Ala Leu 
        35                  40                  45              


Pro Cys Arg Arg Arg Glu Arg Pro Ala Gly Ala Asp Ser Leu Ser Trp 
    50                  55                  60                  


Gly Ala Gly Pro Arg Ile Ser Pro Tyr Val Leu Gln Leu Leu Leu Ala 
65                  70                  75                  80  


Thr Leu Gln Ala Ala Leu Pro Leu Ala Gly Leu Ala Gly Arg Val Gly 
                85                  90                  95      


Thr Ala Arg Gly Ala Pro Leu Pro Ser Tyr Leu Leu Leu Ala Ser Val 
            100                 105                 110         


Leu Glu Ser Leu Ala Gly Ala Cys Gly Leu Trp Leu Leu Val Val Glu 
        115                 120                 125             


Arg Ser Gln Ala Arg Gln Arg Leu Ala Met Gly Ile Trp Ile Lys Phe 
    130                 135                 140                 


Arg His Ser Pro Gly Leu Leu Leu Leu Trp Thr Val Ala Phe Ala Ala 
145                 150                 155                 160 


Glu Asn Leu Ala Leu Val Ser Trp Asn Ser Pro Gln Trp Trp Trp Ala 
                165                 170                 175     


Arg Ala Asp Leu Gly Gln Gln Val Gln Phe Ser Leu Trp Val Leu Arg 
            180                 185                 190         


Tyr Val Val Ser Gly Gly Leu Phe Val Leu Gly Leu Trp Ala Pro Gly 
        195                 200                 205             


Leu Arg Pro Gln Ser Tyr Thr Leu Gln Val His Glu Glu Asp Gln Asp 
    210                 215                 220                 


Val Glu Arg Ser Gln Val Arg Ser Ala Ala Gln Gln Ser Thr Trp Arg 
225                 230                 235                 240 


Asp Phe Gly Arg Lys Leu Arg Leu Leu Ser Gly Tyr Leu Trp Pro Arg 
                245                 250                 255     


Gly Ser Pro Ala Leu Gln Leu Val Val Leu Ile Cys Leu Gly Leu Met 
            260                 265                 270         


Gly Leu Glu Arg Ala Leu Asn Val Leu Val Pro Ile Phe Tyr Arg Asn 
        275                 280                 285             


Ile Val Asn Leu Leu Thr Glu Lys Ala Pro Trp Asn Ser Leu Ala Trp 
    290                 295                 300                 


Thr Val Thr Ser Tyr Val Phe Leu Lys Phe Leu Gln Gly Gly Gly Thr 
305                 310                 315                 320 


Gly Ser Thr Gly Phe Val Ser Asn Leu Arg Thr Phe Leu Trp Ile Arg 
                325                 330                 335     


Val Gln Gln Phe Thr Ser Arg Arg Val Glu Leu Leu Ile Phe Ser His 
            340                 345                 350         


Leu His Glu Leu Ser Leu Arg Trp His Leu Gly Arg Arg Thr Gly Glu 
        355                 360                 365             


Val Leu Arg Ile Ala Asp Arg Gly Thr Ser Ser Val Thr Gly Leu Leu 
    370                 375                 380                 


Ser Tyr Leu Val Phe Asn Val Ile Pro Thr Leu Ala Asp Ile Ile Ile 
385                 390                 395                 400 


Gly Ile Ile Tyr Phe Ser Met Phe Phe Asn Ala Trp Phe Gly Leu Ile 
                405                 410                 415     


Val Phe Leu Cys Met Ser Leu Tyr Leu Thr Leu Thr Ile Val Val Thr 
            420                 425                 430         


Glu Trp Arg Thr Lys Phe Arg Arg Ala Met Asn Thr Gln Glu Asn Ala 
        435                 440                 445             


Thr Arg Ala Arg Ala Val Asp Ser Leu Leu Asn Phe Glu Thr Val Lys 
    450                 455                 460                 


Tyr Tyr Asn Ala Glu Ser Tyr Glu Val Glu Arg Tyr Arg Glu Ala Ile 
465                 470                 475                 480 


Ile Lys Tyr Gln Gly Leu Glu Trp Lys Ser Ser Ala Ser Leu Val Leu 
                485                 490                 495     


Leu Asn Gln Thr Gln Asn Leu Val Ile Gly Leu Gly Leu Leu Ala Gly 
            500                 505                 510         


Ser Leu Leu Cys Ala Tyr Phe Val Thr Glu Gln Lys Leu Gln Val Gly 
        515                 520                 525             


Asp Tyr Val Leu Phe Gly Thr Tyr Ile Ile Gln Leu Tyr Met Pro Leu 
    530                 535                 540                 


Asn Trp Phe Gly Thr Tyr Tyr Arg Met Ile Gln Thr Asn Phe Ile Asp 
545                 550                 555                 560 


Met Glu Asn Met Phe Asp Leu Leu Lys Glu Glu Thr Glu Val Lys Asp 
                565                 570                 575     


Leu Pro Gly Ala Gly Pro Leu Arg Phe Gln Lys Gly Arg Ile Glu Phe 
            580                 585                 590         


Glu Asn Val His Phe Ser Tyr Ala Asp Gly Arg Glu Thr Leu Gln Asp 
        595                 600                 605             


Val Ser Phe Thr Val Met Pro Gly Gln Thr Leu Ala Leu Val Gly Pro 
    610                 615                 620                 


Ser Gly Ala Gly Lys Ser Thr Ile Leu Arg Leu Leu Phe Arg Phe Tyr 
625                 630                 635                 640 


Asp Ile Ser Ser Gly Cys Ile Arg Ile Asp Gly Gln Asp Ile Ser Gln 
                645                 650                 655     


Val Thr Gln Ala Ser Leu Arg Ser His Ile Gly Val Val Pro Gln Asp 
            660                 665                 670         


Thr Val Leu Phe Asn Asp Thr Ile Ala Asp Asn Ile Arg Tyr Gly Arg 
        675                 680                 685             


Val Thr Ala Gly Asn Asp Glu Val Glu Ala Ala Ala Gln Ala Ala Gly 
    690                 695                 700                 


Ile His Asp Ala Ile Met Ala Phe Pro Glu Gly Tyr Arg Thr Gln Val 
705                 710                 715                 720 


Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Glu Lys Gln Arg Val Ala 
                725                 730                 735     


Ile Ala Arg Thr Ile Leu Lys Ala Pro Gly Ile Ile Leu Leu Asp Glu 
            740                 745                 750         


Ala Thr Ser Ala Leu Asp Thr Ser Asn Glu Arg Ala Ile Gln Ala Ser 
        755                 760                 765             


Leu Ala Lys Val Cys Ala Asn Arg Thr Thr Ile Val Val Ala His Arg 
    770                 775                 780                 


Leu Ser Thr Val Val Asn Ala Asp Gln Ile Leu Val Ile Lys Asp Gly 
785                 790                 795                 800 


Cys Ile Val Glu Arg Gly Arg His Glu Ala Leu Leu Ser Arg Gly Gly 
                805                 810                 815     


Val Tyr Ala Asp Met Trp Gln Leu Gln Gln Gly Gln Glu Glu Thr Ser 
            820                 825                 830         


Glu Asp Thr Lys Pro Gln Thr Met Glu Arg 
        835                 840         


<210>  66
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Gly Ser Tyr Pro Glu Gly Ala Pro Ala Ile Leu Ala Asp Lys 
1               5                   10                  15      


Arg Gln Gln Phe Gly Ser Arg Phe Leu Ser Asp Pro Ala Arg Val Phe 
            20                  25                  30          


His His Asn Ala Trp Asp Asn Val Glu Trp Ser Glu Glu Gln Ala Ala 
        35                  40                  45              


Ala Ala Glu Arg Lys Val Gln Glu Asn Ser Ile Gln Arg Val Cys Gln 
    50                  55                  60                  


Glu Lys Gln Val Asp Tyr Glu Ile Asn Ala His Lys Tyr Trp Asn Asp 
65                  70                  75                  80  


Phe Tyr Lys Ile His Glu Asn Gly Phe Phe Lys Asp Arg His Trp Leu 
                85                  90                  95      


Phe Thr Glu Phe Pro Glu Leu Ala Pro Ser Gln Asn Gln Asn His Leu 
            100                 105                 110         


Lys Asp Trp Phe Leu Glu Asn Lys Ser Glu Val Cys Glu Cys Arg Asn 
        115                 120                 125             


Asn Glu Asp Gly Pro Gly Leu Ile Met Glu Glu Gln His Lys Cys Ser 
    130                 135                 140                 


Ser Lys Ser Leu Glu His Lys Thr Gln Thr Pro Pro Val Glu Glu Asn 
145                 150                 155                 160 


Val Thr Gln Lys Ile Ser Asp Leu Glu Ile Cys Ala Asp Glu Phe Pro 
                165                 170                 175     


Gly Ser Ser Ala Thr Tyr Arg Ile Leu Glu Val Gly Cys Gly Val Gly 
            180                 185                 190         


Asn Thr Val Phe Pro Ile Leu Gln Thr Asn Asn Asp Pro Gly Leu Phe 
        195                 200                 205             


Val Tyr Cys Cys Asp Phe Ser Ser Thr Ala Ile Glu Leu Val Gln Thr 
    210                 215                 220                 


Asn Ser Glu Tyr Asp Pro Ser Arg Cys Phe Ala Phe Val His Asp Leu 
225                 230                 235                 240 


Cys Asp Glu Glu Lys Ser Tyr Pro Val Pro Lys Gly Ser Leu Asp Ile 
                245                 250                 255     


Ile Ile Leu Ile Phe Val Leu Ser Ala Val Val Pro Asp Lys Met Gln 
            260                 265                 270         


Lys Ala Ile Asn Arg Leu Ser Arg Leu Leu Lys Pro Gly Gly Met Val 
        275                 280                 285             


Leu Leu Arg Asp Tyr Gly Arg Tyr Asp Met Ala Gln Leu Arg Phe Lys 
    290                 295                 300                 


Lys Gly Gln Cys Leu Ser Gly Asn Phe Tyr Val Arg Gly Asp Gly Thr 
305                 310                 315                 320 


Arg Val Tyr Phe Phe Thr Gln Glu Glu Leu Asp Thr Leu Phe Thr Thr 
                325                 330                 335     


Ala Gly Leu Glu Lys Val Gln Asn Leu Val Asp Arg Arg Leu Gln Val 
            340                 345                 350         


Asn Arg Gly Lys Gln Leu Thr Met Tyr Arg Val Trp Ile Gln Cys Lys 
        355                 360                 365             


Tyr Cys Lys Pro Leu Leu Ser Ser Thr Ser 
    370                 375             


<210>  67
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ala Gly Ser Tyr Pro Glu Gly Ala Pro Ala Val Leu Ala Asp Lys 
1               5                   10                  15      


Arg Gln Gln Phe Gly Ser Arg Phe Leu Arg Asp Pro Ala Arg Val Phe 
            20                  25                  30          


His His Asn Ala Trp Asp Asn Val Glu Trp Ser Glu Glu Gln Ala Ala 
        35                  40                  45              


Ala Ala Glu Arg Lys Val Gln Glu Asn Ser Ile Gln Arg Val Cys Gln 
    50                  55                  60                  


Glu Lys Gln Val Asp Tyr Glu Ile Asn Ala His Lys Tyr Trp Asn Asp 
65                  70                  75                  80  


Phe Tyr Lys Ile His Glu Asn Gly Phe Phe Lys Asp Arg His Trp Leu 
                85                  90                  95      


Phe Thr Glu Phe Pro Glu Leu Ala Pro Ser Gln Asn Gln Asn His Leu 
            100                 105                 110         


Lys Asp Trp Phe Leu Glu Asn Lys Ser Glu Val Pro Glu Cys Arg Asn 
        115                 120                 125             


Asn Glu Asp Gly Pro Gly Leu Ile Met Glu Glu Gln His Lys Cys Ser 
    130                 135                 140                 


Ser Lys Ser Leu Glu His Lys Thr Gln Thr Leu Pro Val Glu Glu Asn 
145                 150                 155                 160 


Val Thr Gln Lys Ile Ser Asp Leu Glu Ile Cys Ala Asp Glu Phe Pro 
                165                 170                 175     


Gly Ser Ser Ala Thr Tyr Arg Ile Leu Glu Val Gly Cys Gly Val Gly 
            180                 185                 190         


Asn Thr Val Phe Pro Ile Leu Gln Thr Asn Asn Asp Pro Gly Leu Phe 
        195                 200                 205             


Val Tyr Cys Cys Asp Phe Ser Ser Thr Ala Ile Glu Leu Val Gln Thr 
    210                 215                 220                 


Asn Ser Glu Tyr Asp Pro Ser Arg Cys Phe Ala Phe Val His Asp Leu 
225                 230                 235                 240 


Cys Asp Glu Glu Lys Ser Tyr Pro Val Pro Lys Gly Ser Leu Asp Ile 
                245                 250                 255     


Ile Ile Leu Ile Phe Val Leu Ser Ala Ile Val Pro Asp Lys Met Gln 
            260                 265                 270         


Lys Ala Ile Asn Arg Leu Ser Arg Leu Leu Lys Pro Gly Gly Met Met 
        275                 280                 285             


Leu Leu Arg Asp Tyr Gly Arg Tyr Asp Met Ala Gln Leu Arg Phe Lys 
    290                 295                 300                 


Lys Gly Gln Cys Leu Ser Gly Asn Phe Tyr Val Arg Gly Asp Gly Thr 
305                 310                 315                 320 


Arg Val Tyr Phe Phe Thr Gln Glu Glu Leu Asp Thr Leu Phe Thr Thr 
                325                 330                 335     


Ala Gly Leu Glu Lys Val Gln Asn Leu Val Asp Arg Arg Leu Gln Val 
            340                 345                 350         


Asn Arg Gly Lys Gln Leu Thr Met Tyr Arg Val Trp Ile Gln Cys Lys 
        355                 360                 365             


Tyr Cys Lys Pro Leu Leu Ser Ser Thr Ser 
    370                 375             


<210>  68
<211>  827
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Leu Leu Cys Leu Ser Pro Ala Trp Leu Met Lys Val Pro Ala Pro 
1               5                   10                  15      


Gly Gln Pro Gly Glu Ala Ala Leu Leu Val Ser Lys Ala Val Ser Phe 
            20                  25                  30          


His Pro Gly Gly Leu Thr Phe Leu Asp Asp Phe Val Pro Pro Arg Arg 
        35                  40                  45              


Ala Thr Tyr Phe Leu Ala Gly Leu Gly Leu Gly Pro Gly Arg Gly Arg 
    50                  55                  60                  


Glu Ala Ala Glu Leu Ala Arg Asp Leu Thr Cys Pro Thr Gly Ala Ser 
65                  70                  75                  80  


Ala Glu Leu Ala Arg Leu Leu Glu Asp Arg Leu Leu Thr Arg Gln Leu 
                85                  90                  95      


Leu Ala Gln Gln Gly Gly Val Ala Val Pro Ala Thr Leu Ala Phe Thr 
            100                 105                 110         


Tyr Lys Pro Pro Gly Leu Leu Arg Gly Gly Asp Ala Ser Leu Gly Leu 
        115                 120                 125             


Arg Leu Val Glu Leu Ser Gly Lys Glu Gly Gln Glu Thr Leu Val Lys 
    130                 135                 140                 


Glu Glu Val Glu Ala Phe Leu Arg Ser Glu Ala Leu Gly Asp Ile Leu 
145                 150                 155                 160 


Gln Val Ala Val Lys Leu Ser Gly Trp Arg Trp Arg Gly Arg Gln Ala 
                165                 170                 175     


Trp Arg Leu His Pro Arg Ala Glu Leu Gly Ala Val Val Asp Thr Val 
            180                 185                 190         


Leu Ala Leu Leu Glu Lys Leu Glu Glu Glu Glu Ser Val Leu Val Glu 
        195                 200                 205             


Ala Val Tyr Pro Pro Ala Gln Leu Pro Cys Ser Asp Gly Pro Ser Pro 
    210                 215                 220                 


Gly Pro Gly Leu Ala Val Arg Ile Cys Ala Val Val Cys Arg Thr Gln 
225                 230                 235                 240 


Gly Asp Arg Pro Leu Leu Ser Lys Val Val Cys Gly Val Gly Arg Gly 
                245                 250                 255     


Asp Arg Pro Leu Arg His His Asn Ser Leu Pro Arg Thr Leu Glu Val 
            260                 265                 270         


Ala Leu Ala Gln Cys Gly Leu Gly Glu Glu Ala Gln Val Ala Ala Val 
        275                 280                 285             


Arg Gln Arg Val Lys Ala Ala Ala Glu Ala Ala Leu Ala Ala Val Leu 
    290                 295                 300                 


Ala Leu Glu Ala Gly Leu Ser Ala Glu Gln Arg Gly Gly Arg Arg Ala 
305                 310                 315                 320 


His Thr Asp Phe Leu Gly Val Asp Phe Ala Leu Thr Ala Ala Gly Gly 
                325                 330                 335     


Val Leu Thr Pro Val Ala Leu Glu Leu Asn Gly Gly Leu Cys Leu Glu 
            340                 345                 350         


Ala Cys Gly Ala Leu Glu Gly Leu Trp Ala Ala Pro Arg Leu Gly Pro 
        355                 360                 365             


Ala Ala Asp Glu Ala Val Ala Ala Pro Leu Val Glu Thr Met Leu Arg 
    370                 375                 380                 


Arg Ser Ala Arg Cys Leu Met Glu Gly Lys Gln Leu Leu Val Val Gly 
385                 390                 395                 400 


Ala Gly Gly Val Ser Lys Lys Phe Val Trp Glu Ala Ala Arg Asp Tyr 
                405                 410                 415     


Gly Leu Gln Leu His Leu Val Glu Ser Asp Pro Asn His Phe Ala Ser 
            420                 425                 430         


Gln Leu Val Gln Thr Phe Ile His Phe Asp Met Thr Glu His Arg Arg 
        435                 440                 445             


Asp Glu Glu Asn Ala Arg Leu Leu Ala Glu Leu Val Arg Ala Arg Gly 
    450                 455                 460                 


Leu Lys Leu Asp Gly Cys Phe Ser Tyr Trp Asp Asp Cys Leu Val Leu 
465                 470                 475                 480 


Thr Ala Leu Leu Cys Gln Glu Leu Gly Leu Pro Cys Ser Ser Pro Ala 
                485                 490                 495     


Ala Met Arg Leu Ala Lys Gln Lys Ser Leu Thr Gln Leu His Leu Leu 
            500                 505                 510         


His His His Gly Pro Pro Trp Pro Ala Pro Ser Leu His Ala Val Pro 
        515                 520                 525             


Cys Cys Pro Leu Glu Ser Glu Ala Asp Val Glu Arg Ala Val His Gln 
    530                 535                 540                 


Val Pro Leu Pro Gly Val Met Lys Leu Glu Phe Gly Ala Gly Ala Val 
545                 550                 555                 560 


Gly Val Arg Leu Val Glu Asp Ala Pro Gln Cys His Glu His Phe Ser 
                565                 570                 575     


Arg Ile Thr Arg Asp Leu Gln Gly Glu Ala Asp His Pro Gly Ile Gly 
            580                 585                 590         


Leu Gly Trp Gly Asn Ala Met Leu Leu Met Glu Phe Val Glu Gly Thr 
        595                 600                 605             


Glu His Asp Val Asp Leu Val Leu Phe Gly Gly Arg Leu Leu Ala Ala 
    610                 615                 620                 


Phe Val Ser Asp Asn Gly Pro Thr Arg Leu Pro Gly Phe Thr Glu Thr 
625                 630                 635                 640 


Ala Ala Cys Met Pro Thr Gly Leu Ala Pro Glu Gln Glu Ala Gln Met 
                645                 650                 655     


Val Gln Ala Ala Phe Arg Cys Cys Leu Gly Cys Gly Leu Leu Asp Gly 
            660                 665                 670         


Val Phe Asn Val Glu Leu Lys Leu Thr Gly Ala Gly Pro Arg Leu Ile 
        675                 680                 685             


Glu Ile Asn Pro Arg Met Gly Gly Phe Tyr Leu Arg Asp Trp Ile Leu 
    690                 695                 700                 


Glu Leu Tyr Gly Val Asp Leu Leu Leu Ala Ala Val Met Val Ala Cys 
705                 710                 715                 720 


Gly Leu Arg Pro Ala Leu Pro Thr Arg Pro Arg Ala Arg Gly His Leu 
                725                 730                 735     


Val Gly Val Met Cys Leu Val Ser Gln His Leu Gln Ala Leu Ser Ser 
            740                 745                 750         


Thr Ala Ser Arg Glu Thr Leu Gln Ala Leu His Asp Arg Gly Leu Leu 
        755                 760                 765             


Arg Leu Asn Leu Leu Glu Glu Ala Leu Val Pro Gly Glu Tyr Glu Glu 
    770                 775                 780                 


Pro Tyr Cys Ser Val Ala Cys Ala Gly Pro Ser Pro Thr Glu Ala Arg 
785                 790                 795                 800 


Leu Arg Leu Leu Gly Leu Cys Gln Gly Leu Gly Ile Asp Gly Pro Ser 
                805                 810                 815     


Tyr Pro Val Ala His Phe Leu Ser His Phe Lys 
            820                 825         


<210>  69
<211>  2364
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Thr Thr Thr Val Ala Thr Asp Tyr Asp Asn Ile Glu Ile Gln Gln 
1               5                   10                  15      


Gln Tyr Ser Asp Val Asn Asn Arg Trp Asp Val Asp Asp Trp Asp Asn 
            20                  25                  30          


Glu Asn Ser Ser Ala Arg Leu Phe Glu Arg Ser Arg Ile Lys Ala Leu 
        35                  40                  45              


Ala Asp Glu Arg Glu Ala Val Gln Lys Lys Thr Phe Thr Lys Trp Val 
    50                  55                  60                  


Asn Ser His Leu Ala Arg Val Ser Cys Arg Ile Thr Asp Leu Tyr Thr 
65                  70                  75                  80  


Asp Leu Arg Asp Gly Arg Met Leu Ile Lys Leu Leu Glu Val Leu Ser 
                85                  90                  95      


Gly Glu Arg Leu Pro Lys Pro Thr Lys Gly Arg Met Arg Ile His Cys 
            100                 105                 110         


Leu Glu Asn Val Asp Lys Ala Leu Gln Phe Leu Lys Glu Gln Arg Val 
        115                 120                 125             


His Leu Glu Asn Met Gly Ser His Asp Ile Val Asp Gly Asn His Arg 
    130                 135                 140                 


Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu Arg Phe Gln Ile Gln 
145                 150                 155                 160 


Asp Ile Ser Val Glu Thr Glu Asp Asn Lys Glu Lys Lys Ser Ala Lys 
                165                 170                 175     


Asp Ala Leu Leu Leu Trp Cys Gln Met Lys Thr Ala Gly Tyr Pro Asn 
            180                 185                 190         


Val Asn Ile His Asn Phe Thr Thr Ser Trp Arg Asp Gly Met Ala Phe 
        195                 200                 205             


Asn Ala Leu Ile His Lys His Arg Pro Asp Leu Ile Asp Phe Asp Lys 
    210                 215                 220                 


Leu Lys Lys Ser Asn Ala His Tyr Asn Leu Gln Asn Ala Phe Asn Leu 
225                 230                 235                 240 


Ala Glu Gln His Leu Gly Leu Thr Lys Leu Leu Asp Pro Glu Asp Ile 
                245                 250                 255     


Ser Val Asp His Pro Asp Glu Lys Ser Ile Ile Thr Tyr Val Val Thr 
            260                 265                 270         


Tyr Tyr His Tyr Phe Ser Lys Met Lys Ala Leu Ala Val Glu Gly Lys 
        275                 280                 285             


Arg Ile Gly Lys Val Leu Asp Asn Ala Ile Glu Thr Glu Lys Met Ile 
    290                 295                 300                 


Glu Lys Tyr Glu Ser Leu Ala Ser Asp Leu Leu Glu Trp Ile Glu Gln 
305                 310                 315                 320 


Thr Ile Ile Ile Leu Asn Asn Arg Lys Phe Ala Asn Ser Leu Val Gly 
                325                 330                 335     


Val Gln Gln Gln Leu Gln Ala Phe Asn Thr Tyr Arg Thr Val Glu Lys 
            340                 345                 350         


Pro Pro Lys Phe Thr Glu Lys Gly Asn Leu Glu Val Leu Leu Phe Thr 
        355                 360                 365             


Ile Gln Ser Lys Met Arg Ala Asn Asn Gln Lys Val Tyr Met Pro Arg 
    370                 375                 380                 


Glu Gly Lys Leu Ile Ser Asp Ile Asn Lys Ala Trp Glu Arg Leu Glu 
385                 390                 395                 400 


Lys Ala Glu His Glu Arg Glu Leu Ala Leu Arg Asn Glu Leu Ile Arg 
                405                 410                 415     


Gln Glu Lys Leu Glu Gln Leu Ala Arg Arg Phe Asp Arg Lys Ala Ala 
            420                 425                 430         


Met Arg Glu Thr Trp Leu Ser Glu Asn Gln Arg Leu Val Ser Gln Asp 
        435                 440                 445             


Asn Phe Gly Phe Asp Leu Pro Ala Val Glu Ala Ala Thr Lys Lys His 
    450                 455                 460                 


Glu Ala Ile Glu Thr Asp Ile Ala Ala Tyr Glu Glu Arg Val Gln Ala 
465                 470                 475                 480 


Val Val Ala Val Ala Arg Glu Leu Glu Ala Glu Asn Tyr His Asp Ile 
                485                 490                 495     


Lys Arg Ile Thr Ala Arg Lys Asp Asn Val Ile Arg Leu Trp Glu Tyr 
            500                 505                 510         


Leu Leu Glu Leu Leu Arg Ala Arg Arg Gln Arg Leu Glu Met Asn Leu 
        515                 520                 525             


Gly Leu Gln Lys Ile Phe Gln Glu Met Leu Tyr Ile Met Asp Trp Met 
    530                 535                 540                 


Asp Glu Met Lys Val Leu Val Leu Ser Gln Asp Tyr Gly Lys His Leu 
545                 550                 555                 560 


Leu Gly Val Glu Asp Leu Leu Gln Lys His Thr Leu Val Glu Ala Asp 
                565                 570                 575     


Ile Gly Ile Gln Ala Glu Arg Val Arg Gly Val Asn Ala Ser Ala Gln 
            580                 585                 590         


Lys Phe Ala Thr Asp Gly Glu Gly Tyr Lys Pro Cys Asp Pro Gln Val 
        595                 600                 605             


Ile Arg Asp Arg Val Ala His Met Glu Phe Cys Tyr Gln Glu Leu Cys 
    610                 615                 620                 


Gln Leu Ala Ala Glu Arg Arg Ala Arg Leu Glu Glu Ser Arg Arg Leu 
625                 630                 635                 640 


Trp Lys Phe Phe Trp Glu Met Ala Glu Glu Glu Gly Trp Ile Arg Glu 
                645                 650                 655     


Lys Glu Lys Ile Leu Ser Ser Asp Asp Tyr Gly Lys Asp Leu Thr Ser 
            660                 665                 670         


Val Met Arg Leu Leu Ser Lys His Arg Ala Phe Glu Asp Glu Met Ser 
        675                 680                 685             


Gly Arg Ser Gly His Phe Glu Gln Ala Ile Lys Glu Gly Glu Asp Met 
    690                 695                 700                 


Ile Ala Glu Glu His Phe Gly Ser Glu Lys Ile Arg Glu Arg Ile Ile 
705                 710                 715                 720 


Tyr Ile Arg Glu Gln Trp Ala Asn Leu Glu Gln Leu Ser Ala Ile Arg 
                725                 730                 735     


Lys Lys Arg Leu Glu Glu Ala Ser Leu Leu His Gln Phe Gln Ala Asp 
            740                 745                 750         


Ala Asp Asp Ile Asp Ala Trp Met Leu Asp Ile Leu Lys Ile Val Ser 
        755                 760                 765             


Ser Ser Asp Val Gly His Asp Glu Tyr Ser Thr Gln Ser Leu Val Lys 
    770                 775                 780                 


Lys His Lys Asp Val Ala Glu Glu Ile Ala Asn Tyr Arg Pro Thr Leu 
785                 790                 795                 800 


Asp Thr Leu His Glu Gln Ala Ser Ala Leu Pro Gln Glu His Ala Glu 
                805                 810                 815     


Ser Pro Asp Val Arg Gly Arg Leu Ser Gly Ile Glu Glu Arg Tyr Lys 
            820                 825                 830         


Glu Val Ala Glu Leu Thr Arg Leu Arg Lys Gln Ala Leu Gln Asp Thr 
        835                 840                 845             


Leu Ala Leu Tyr Lys Met Phe Ser Glu Ala Asp Ala Cys Glu Leu Trp 
    850                 855                 860                 


Ile Asp Glu Lys Glu Gln Trp Leu Asn Asn Met Gln Ile Pro Glu Lys 
865                 870                 875                 880 


Leu Glu Asp Leu Glu Val Ile Gln His Arg Phe Glu Ser Leu Glu Pro 
                885                 890                 895     


Glu Met Asn Asn Gln Ala Ser Arg Val Ala Val Val Asn Gln Ile Ala 
            900                 905                 910         


Arg Gln Leu Met His Ser Gly His Pro Ser Glu Lys Glu Ile Lys Ala 
        915                 920                 925             


Gln Gln Asp Lys Leu Asn Thr Arg Trp Ser Gln Phe Arg Glu Leu Val 
    930                 935                 940                 


Asp Arg Lys Lys Asp Ala Leu Leu Ser Ala Leu Ser Ile Gln Asn Tyr 
945                 950                 955                 960 


His Leu Glu Cys Asn Glu Thr Lys Ser Trp Ile Arg Glu Lys Thr Lys 
                965                 970                 975     


Val Ile Glu Ser Thr Gln Asp Leu Gly Asn Asp Leu Ala Gly Val Met 
            980                 985                 990         


Ala Leu Gln Arg Lys Leu Thr Gly  Met Glu Arg Asp Leu  Val Ala Ile 
        995                 1000                 1005             


Glu Ala  Lys Leu Ser Asp Leu  Gln Lys Glu Ala Glu  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  His Pro Asp Gln Ala  Gln Ala Ile Leu Ser  Arg Leu Ala 
    1025                 1030                 1035             


Glu Ile  Ser Asp Val Trp Glu  Glu Met Lys Thr Thr  Leu Lys Asn 
    1040                 1045                 1050             


Arg Glu  Ala Ser Leu Gly Glu  Ala Ser Lys Leu Gln  Gln Phe Leu 
    1055                 1060                 1065             


Arg Asp  Leu Asp Asp Phe Gln  Ser Trp Leu Ser Arg  Thr Gln Thr 
    1070                 1075                 1080             


Ala Ile  Ala Ser Glu Asp Met  Pro Asn Thr Leu Thr  Glu Ala Glu 
    1085                 1090                 1095             


Lys Leu  Leu Thr Gln His Glu  Asn Ile Lys Asn Glu  Ile Asp Asn 
    1100                 1105                 1110             


Tyr Glu  Glu Asp Tyr Gln Lys  Met Arg Asp Met Gly  Glu Met Val 
    1115                 1120                 1125             


Thr Gln  Gly Gln Thr Asp Ala  Gln Tyr Met Phe Leu  Arg Gln Arg 
    1130                 1135                 1140             


Leu Gln  Ala Leu Asp Thr Gly  Trp Asn Glu Leu His  Lys Met Trp 
    1145                 1150                 1155             


Glu Asn  Arg Gln Asn Leu Leu  Ser Gln Ser His Ala  Tyr Gln Gln 
    1160                 1165                 1170             


Phe Leu  Arg Asp Thr Lys Gln  Ala Glu Ala Phe Leu  Asn Asn Gln 
    1175                 1180                 1185             


Glu Tyr  Val Leu Ala His Thr  Glu Met Pro Thr Thr  Leu Glu Gly 
    1190                 1195                 1200             


Ala Glu  Ala Ala Ile Lys Lys  Gln Glu Asp Phe Met  Thr Thr Met 
    1205                 1210                 1215             


Asp Ala  Asn Glu Glu Lys Ile  Asn Ala Val Val Glu  Thr Gly Arg 
    1220                 1225                 1230             


Arg Leu  Val Ser Asp Gly Asn  Ile Asn Ser Asp Arg  Ile Gln Glu 
    1235                 1240                 1245             


Lys Val  Asp Ser Ile Asp Asp  Arg His Arg Lys Asn  Arg Glu Thr 
    1250                 1255                 1260             


Ala Ser  Glu Leu Leu Met Arg  Leu Lys Asp Asn Arg  Asp Leu Gln 
    1265                 1270                 1275             


Lys Phe  Leu Gln Asp Cys Gln  Glu Leu Ser Leu Trp  Ile Asn Glu 
    1280                 1285                 1290             


Lys Met  Leu Thr Ala Gln Asp  Met Ser Tyr Asp Glu  Ala Arg Asn 
    1295                 1300                 1305             


Leu His  Ser Lys Trp Leu Lys  His Gln Ala Phe Met  Ala Glu Leu 
    1310                 1315                 1320             


Ala Ser  Asn Lys Glu Trp Leu  Asp Lys Ile Glu Lys  Glu Gly Met 
    1325                 1330                 1335             


Gln Leu  Ile Ser Glu Lys Pro  Glu Thr Glu Ala Val  Val Lys Glu 
    1340                 1345                 1350             


Lys Leu  Thr Gly Leu His Lys  Met Trp Glu Val Leu  Glu Ser Thr 
    1355                 1360                 1365             


Thr Gln  Thr Lys Ala Gln Arg  Leu Phe Asp Ala Asn  Lys Ala Glu 
    1370                 1375                 1380             


Leu Phe  Thr Gln Ser Cys Ala  Asp Leu Asp Lys Trp  Leu His Gly 
    1385                 1390                 1395             


Leu Glu  Ser Gln Ile Gln Ser  Asp Asp Tyr Gly Lys  Asp Leu Thr 
    1400                 1405                 1410             


Ser Val  Asn Ile Leu Leu Lys  Lys Gln Gln Met Leu  Glu Asn Gln 
    1415                 1420                 1425             


Met Glu  Val Arg Lys Lys Glu  Ile Glu Glu Leu Gln  Ser Gln Ala 
    1430                 1435                 1440             


Gln Ala  Leu Ser Gln Glu Gly  Lys Ser Thr Asp Glu  Val Asp Ser 
    1445                 1450                 1455             


Lys Arg  Leu Thr Val Gln Thr  Lys Phe Met Glu Leu  Leu Glu Pro 
    1460                 1465                 1470             


Leu Asn  Glu Arg Lys His Asn  Leu Leu Ala Ser Lys  Glu Ile His 
    1475                 1480                 1485             


Gln Phe  Asn Arg Asp Val Glu  Asp Glu Ile Leu Trp  Val Gly Glu 
    1490                 1495                 1500             


Arg Met  Pro Leu Ala Thr Ser  Thr Asp His Gly His  Asn Leu Gln 
    1505                 1510                 1515             


Thr Val  Gln Leu Leu Ile Lys  Lys Asn Gln Thr Leu  Gln Lys Glu 
    1520                 1525                 1530             


Ile Gln  Gly His Gln Pro Arg  Ile Asp Asp Ile Phe  Glu Arg Ser 
    1535                 1540                 1545             


Gln Asn  Ile Val Thr Asp Ser  Ser Ser Leu Ser Ala  Glu Ala Ile 
    1550                 1555                 1560             


Arg Gln  Arg Leu Ala Asp Leu  Lys Gln Leu Trp Gly  Leu Leu Ile 
    1565                 1570                 1575             


Glu Glu  Thr Glu Lys Arg His  Arg Arg Leu Glu Glu  Ala His Arg 
    1580                 1585                 1590             


Ala Gln  Gln Tyr Tyr Phe Asp  Ala Ala Glu Ala Glu  Ala Trp Met 
    1595                 1600                 1605             


Ser Glu  Gln Glu Leu Tyr Met  Met Ser Glu Glu Lys  Ala Lys Asp 
    1610                 1615                 1620             


Glu Gln  Ser Ala Val Ser Met  Leu Lys Lys His Gln  Ile Leu Glu 
    1625                 1630                 1635             


Gln Ala  Val Glu Asp Tyr Ala  Glu Thr Val His Gln  Leu Ser Lys 
    1640                 1645                 1650             


Thr Ser  Arg Ala Leu Val Ala  Asp Ser His Pro Glu  Ser Glu Arg 
    1655                 1660                 1665             


Ile Ser  Met Arg Gln Ser Lys  Val Asp Lys Leu Tyr  Ala Gly Leu 
    1670                 1675                 1680             


Lys Asp  Leu Ala Glu Glu Arg  Arg Gly Lys Leu Asp  Glu Arg His 
    1685                 1690                 1695             


Arg Leu  Phe Gln Leu Asn Arg  Glu Val Asp Asp Leu  Glu Gln Trp 
    1700                 1705                 1710             


Ile Ala  Glu Arg Glu Val Val  Ala Gly Ser His Glu  Leu Gly Gln 
    1715                 1720                 1725             


Asp Tyr  Glu His Val Thr Met  Leu Gln Glu Arg Phe  Arg Glu Phe 
    1730                 1735                 1740             


Ala Arg  Asp Thr Gly Asn Ile  Gly Gln Glu Arg Val  Asp Thr Val 
    1745                 1750                 1755             


Asn His  Leu Ala Asp Glu Leu  Ile Asn Ser Gly His  Ser Asp Ala 
    1760                 1765                 1770             


Ala Thr  Ile Ala Glu Trp Lys  Asp Gly Leu Asn Glu  Ala Trp Ala 
    1775                 1780                 1785             


Asp Leu  Leu Glu Leu Ile Asp  Thr Arg Thr Gln Ile  Leu Ala Ala 
    1790                 1795                 1800             


Ser Tyr  Glu Leu His Lys Phe  Tyr His Asp Ala Lys  Glu Ile Phe 
    1805                 1810                 1815             


Gly Arg  Ile Gln Asp Lys His  Lys Lys Leu Pro Glu  Glu Leu Gly 
    1820                 1825                 1830             


Arg Asp  Gln Asn Thr Val Glu  Thr Leu Gln Arg Met  His Thr Thr 
    1835                 1840                 1845             


Phe Glu  His Asp Ile Gln Ala  Leu Gly Thr Gln Val  Arg Gln Leu 
    1850                 1855                 1860             


Gln Glu  Asp Ala Ala Arg Leu  Gln Ala Ala Tyr Ala  Gly Asp Lys 
    1865                 1870                 1875             


Ala Asp  Asp Ile Gln Lys Arg  Glu Asn Glu Val Leu  Glu Ala Trp 
    1880                 1885                 1890             


Lys Ser  Leu Leu Asp Ala Cys  Glu Ser Arg Arg Val  Arg Leu Val 
    1895                 1900                 1905             


Asp Thr  Gly Asp Lys Phe Arg  Phe Phe Ser Met Val  Arg Asp Leu 
    1910                 1915                 1920             


Met Leu  Trp Met Glu Asp Val  Ile Arg Gln Ile Glu  Ala Gln Glu 
    1925                 1930                 1935             


Lys Pro  Arg Asp Val Ser Ser  Val Glu Leu Leu Met  Asn Asn His 
    1940                 1945                 1950             


Gln Gly  Ile Lys Ala Glu Ile  Asp Ala Arg Asn Asp  Ser Phe Thr 
    1955                 1960                 1965             


Thr Cys  Ile Glu Leu Gly Lys  Ser Leu Leu Ala Arg  Lys His Tyr 
    1970                 1975                 1980             


Ala Ser  Glu Glu Ile Lys Glu  Lys Leu Leu Gln Leu  Thr Glu Lys 
    1985                 1990                 1995             


Arg Lys  Glu Met Ile Asp Lys  Trp Glu Asp Arg Trp  Glu Trp Leu 
    2000                 2005                 2010             


Arg Leu  Ile Leu Glu Val His  Gln Phe Ser Arg Asp  Ala Ser Val 
    2015                 2020                 2025             


Ala Glu  Ala Trp Leu Leu Gly  Gln Glu Pro Tyr Leu  Ser Ser Arg 
    2030                 2035                 2040             


Glu Ile  Gly Gln Ser Val Asp  Glu Val Glu Lys Leu  Ile Lys Arg 
    2045                 2050                 2055             


His Glu  Ala Phe Glu Lys Ser  Ala Ala Thr Trp Asp  Glu Arg Phe 
    2060                 2065                 2070             


Ser Ala  Leu Glu Arg Leu Thr  Thr Leu Glu Leu Leu  Glu Val Arg 
    2075                 2080                 2085             


Arg Gln  Gln Glu Glu Glu Glu  Arg Lys Arg Arg Pro  Pro Ser Pro 
    2090                 2095                 2100             


Glu Pro  Ser Thr Lys Val Ser  Glu Glu Ala Glu Ser  Gln Gln Gln 
    2105                 2110                 2115             


Trp Asp  Thr Ser Lys Gly Glu  Gln Val Ser Gln Asn  Gly Leu Pro 
    2120                 2125                 2130             


Ala Glu  Gln Gly Ser Pro Arg  Met Ala Glu Thr Val  Asp Thr Ser 
    2135                 2140                 2145             


Glu Met  Val Asn Gly Ala Thr  Glu Gln Arg Thr Ser  Ser Lys Glu 
    2150                 2155                 2160             


Ser Ser  Pro Ile Pro Ser Pro  Thr Ser Asp Arg Lys  Ala Lys Thr 
    2165                 2170                 2175             


Ala Leu  Pro Ala Gln Ser Ala  Ala Thr Leu Pro Ala  Arg Thr Gln 
    2180                 2185                 2190             


Glu Thr  Pro Ser Ala Gln Met  Glu Gly Phe Leu Asn  Arg Lys His 
    2195                 2200                 2205             


Glu Trp  Glu Ala His Asn Lys  Lys Ala Ser Ser Arg  Ser Trp His 
    2210                 2215                 2220             


Asn Val  Tyr Cys Val Ile Asn  Asn Gln Glu Met Gly  Phe Tyr Lys 
    2225                 2230                 2235             


Asp Ala  Lys Thr Ala Ala Ser  Gly Ile Pro Tyr His  Ser Glu Val 
    2240                 2245                 2250             


Pro Val  Ser Leu Lys Glu Ala  Val Cys Glu Val Ala  Leu Asp Tyr 
    2255                 2260                 2265             


Lys Lys  Lys Lys His Val Phe  Lys Leu Arg Leu Asn  Asp Gly Asn 
    2270                 2275                 2280             


Glu Tyr  Leu Phe Gln Ala Lys  Asp Asp Glu Glu Met  Asn Thr Trp 
    2285                 2290                 2295             


Ile Gln  Ala Ile Ser Ser Ala  Ile Ser Ser Asp Lys  His Glu Val 
    2300                 2305                 2310             


Ser Ala  Ser Thr Gln Ser Thr  Pro Ala Ser Ser Arg  Ala Gln Thr 
    2315                 2320                 2325             


Leu Pro  Thr Ser Val Val Thr  Ile Thr Ser Glu Ser  Ser Pro Gly 
    2330                 2335                 2340             


Lys Arg  Glu Lys Asp Lys Glu  Lys Asp Lys Glu Lys  Arg Phe Ser 
    2345                 2350                 2355             


Leu Phe  Gly Lys Lys Lys 
    2360                 


<210>  70
<211>  1148
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Ser Ala Pro Ala Glu Ala Glu Thr Arg Gln Arg Leu Leu Arg 
1               5                   10                  15      


Thr Val Lys Lys Glu Val Lys Gln Ile Met Glu Glu Ala Val Thr Arg 
            20                  25                  30          


Lys Phe Val His Glu Asp Ser Ser His Ile Ile Ser Phe Cys Ala Ala 
        35                  40                  45              


Val Glu Ala Cys Val Leu His Gly Leu Arg Arg Arg Ala Ala Gly Phe 
    50                  55                  60                  


Leu Arg Ser Asn Lys Ile Ala Ala Leu Phe Met Lys Val Gly Lys Asn 
65                  70                  75                  80  


Phe Pro Pro Ala Glu Asp Leu Ser Arg Lys Val Gln Asp Leu Glu Gln 
                85                  90                  95      


Leu Ile Glu Ser Ala Arg Asn Gln Ile Gln Gly Leu Gln Glu Asn Val 
            100                 105                 110         


Arg Lys Leu Pro Lys Leu Pro Asn Leu Ser Pro Leu Ala Ile Lys His 
        115                 120                 125             


Leu Trp Ile Arg Thr Ala Leu Phe Glu Lys Val Leu Asp Lys Ile Val 
    130                 135                 140                 


His Tyr Leu Val Glu Asn Ser Ser Lys Tyr Tyr Glu Lys Glu Ala Leu 
145                 150                 155                 160 


Leu Met Asp Pro Val Asp Gly Pro Ile Leu Ala Ser Leu Leu Val Gly 
                165                 170                 175     


Pro Cys Ala Leu Glu Tyr Thr Lys Met Lys Thr Ala Asp His Phe Trp 
            180                 185                 190         


Thr Asp Pro Ser Ala Asp Glu Leu Val Gln Arg His Arg Ile His Ser 
        195                 200                 205             


Ser His Val Arg Gln Asp Ser Pro Thr Lys Arg Pro Ala Leu Cys Ile 
    210                 215                 220                 


Gln Lys Arg His Ser Ser Gly Ser Met Asp Asp Arg Pro Ser Leu Ser 
225                 230                 235                 240 


Ala Arg Asp Tyr Val Glu Ser Leu His Gln Asn Ser Arg Ala Thr Leu 
                245                 250                 255     


Leu Tyr Gly Lys Asn Asn Val Leu Val Gln Pro Arg Asp Asp Met Glu 
            260                 265                 270         


Ala Val Pro Gly Tyr Leu Ser Leu His Gln Thr Ala Asp Val Met Thr 
        275                 280                 285             


Leu Lys Trp Thr Pro Asn Gln Leu Met Asn Gly Ser Val Gly Asp Leu 
    290                 295                 300                 


Asp Tyr Glu Lys Ser Val Tyr Trp Asp Tyr Ala Met Thr Ile Arg Leu 
305                 310                 315                 320 


Glu Glu Ile Val Tyr Leu His Cys His Gln Gln Val Asp Ser Gly Gly 
                325                 330                 335     


Thr Val Val Leu Val Ser Gln Asp Gly Ile Gln Arg Pro Pro Phe Arg 
            340                 345                 350         


Phe Pro Lys Gly Gly His Leu Leu Gln Phe Leu Ser Cys Leu Glu Asn 
        355                 360                 365             


Gly Leu Leu Pro His Gly Gln Leu Asp Pro Pro Leu Trp Ser Gln Arg 
    370                 375                 380                 


Gly Lys Gly Lys Val Phe Pro Lys Leu Arg Lys Arg Ser Pro Gln Gly 
385                 390                 395                 400 


Ser Ala Glu Ser Thr Ser Ser Asp Lys Asp Asp Asp Glu Ala Thr Asp 
                405                 410                 415     


Tyr Val Phe Arg Ile Ile Tyr Pro Gly Met Gln Ser Glu Phe Val Ala 
            420                 425                 430         


Pro Asp Phe Leu Gly Ser Thr Ser Ser Val Ser Val Gly Pro Ala Trp 
        435                 440                 445             


Met Met Val Pro Ala Gly Arg Ser Met Leu Val Val Ala Arg Gly Ser 
    450                 455                 460                 


Gln Trp Glu Pro Ala Arg Trp Asp Thr Thr Leu Pro Thr Pro Ser Pro 
465                 470                 475                 480 


Lys Glu Gln Pro Pro Met Pro Gln Asp Leu Met Asp Val Ser Val Ser 
                485                 490                 495     


Asn Leu Pro Ser Leu Trp Gln Pro Ser Pro Arg Lys Ser Ser Cys Ser 
            500                 505                 510         


Ser Cys Ser Gln Ser Gly Ser Ala Asp Gly Ser Ser Thr Asn Gly Cys 
        515                 520                 525             


Asn His Glu Arg Ala Pro Leu Lys Leu Leu Cys Asp Asn Met Lys Tyr 
    530                 535                 540                 


Gln Ile Leu Ser Arg Ala Phe Tyr Gly Trp Leu Ala Tyr Cys Arg His 
545                 550                 555                 560 


Leu Ser Thr Val Arg Thr His Leu Ser Ala Leu Val Asn His Met Ile 
                565                 570                 575     


Val Ser Pro Asp Leu Pro Cys Asp Ala Gly Gln Gly Leu Thr Ala Arg 
            580                 585                 590         


Ile Trp Glu Gln Tyr Leu His Asp Ser Thr Ser Tyr Glu Glu Gln Glu 
        595                 600                 605             


Leu Leu Arg Leu Ile Tyr Tyr Gly Gly Ile Gln Pro Glu Ile Arg Lys 
    610                 615                 620                 


Ala Val Trp Pro Phe Leu Leu Gly His Tyr Gln Phe Gly Met Thr Glu 
625                 630                 635                 640 


Thr Glu Arg Lys Glu Val Asp Glu Gln Ile His Ala Cys Tyr Ala Gln 
                645                 650                 655     


Thr Met Ala Glu Trp Leu Gly Cys Glu Ala Ile Val Arg Gln Arg Glu 
            660                 665                 670         


Arg Glu Ser His Ala Ala Ala Leu Ala Lys Cys Ser Ser Gly Ala Ser 
        675                 680                 685             


Leu Asp Ser His Leu His Arg Met Leu His Arg Asp Ser Thr Ile Ser 
    690                 695                 700                 


Asn Glu Ser Ser Gln Ser Cys Ser Ser Gly Arg Gln Asn Ile Arg Leu 
705                 710                 715                 720 


His Ser Asp Ser Ser Ser Ser Thr Gln Val Phe Glu Ser Val Asp Glu 
                725                 730                 735     


Val Glu Gln Val Glu Ala Glu Gly Arg Leu Glu Glu Lys Gln Pro Lys 
            740                 745                 750         


Ile Pro Asn Gly Asn Leu Val Asn Gly Thr Cys Ser Pro Asp Ser Gly 
        755                 760                 765             


His Pro Ser Ser His Asn Phe Ser Ser Gly Leu Ser Glu His Ser Glu 
    770                 775                 780                 


Pro Ser Leu Ser Thr Glu Asp Ser Val Leu Asp Ala Gln Arg Asn Thr 
785                 790                 795                 800 


Pro Thr Val Leu Arg Pro Arg Asp Gly Ser Val Asp Asp Arg Gln Ser 
                805                 810                 815     


Ser Glu Ala Thr Thr Ser Gln Asp Glu Ala Pro Arg Glu Glu Leu Ala 
            820                 825                 830         


Val Gln Asp Ser Leu Glu Ser Asp Leu Leu Ala Asn Glu Ser Met Asp 
        835                 840                 845             


Glu Phe Met Ser Ile Thr Gly Ser Leu Asp Met Ala Leu Pro Glu Lys 
    850                 855                 860                 


Asp Asp Val Val Met Glu Gly Trp Arg Ser Ser Glu Thr Glu Lys His 
865                 870                 875                 880 


Gly Gln Ala Asp Ser Glu Asp Asn Leu Ser Glu Glu Pro Glu Met Glu 
                885                 890                 895     


Ser Leu Phe Pro Ala Leu Ala Ser Leu Ala Val Thr Thr Ser Ala Asn 
            900                 905                 910         


Glu Val Ser Pro Val Ser Ser Ser Gly Val Thr Tyr Ser Pro Glu Leu 
        915                 920                 925             


Leu Asp Leu Tyr Thr Val Asn Leu His Arg Ile Glu Lys Asp Val Gln 
    930                 935                 940                 


Arg Cys Asp Arg Asn Tyr Trp Tyr Phe Thr Pro Ala Asn Leu Glu Lys 
945                 950                 955                 960 


Leu Arg Asn Ile Met Cys Ser Tyr Ile Trp Gln His Ile Glu Ile Gly 
                965                 970                 975     


Tyr Val Gln Gly Met Cys Asp Leu Leu Ala Pro Leu Leu Val Ile Leu 
            980                 985                 990         


Asp Asp Glu Ala Leu Ala Phe Ser  Cys Phe Thr Glu Leu  Met Lys Arg 
        995                 1000                 1005             


Met Asn  Gln Asn Phe Pro His  Gly Gly Ala Met Asp  Thr His Phe 
    1010                 1015                 1020             


Ala Asn  Met Arg Ser Leu Ile  Gln Ile Leu Asp Ser  Glu Leu Phe 
    1025                 1030                 1035             


Glu Leu  Met His Gln Asn Gly  Asp Tyr Thr His Phe  Tyr Phe Cys 
    1040                 1045                 1050             


Tyr Arg  Trp Phe Leu Leu Asp  Phe Lys Arg Glu Leu  Val Tyr Asp 
    1055                 1060                 1065             


Asp Val  Phe Leu Val Trp Glu  Thr Ile Trp Ala Ala  Lys His Val 
    1070                 1075                 1080             


Ser Ser  Ala His Tyr Val Leu  Phe Ile Ala Leu Ala  Leu Val Glu 
    1085                 1090                 1095             


Val Tyr  Arg Asp Ile Ile Leu  Glu Asn Asn Met Asp  Phe Thr Asp 
    1100                 1105                 1110             


Ile Ile  Lys Phe Phe Asn Glu  Met Ala Glu Arg His  Asn Thr Lys 
    1115                 1120                 1125             


Gln Val  Leu Lys Leu Ala Arg  Asp Leu Val Tyr Lys  Val Gln Thr 
    1130                 1135                 1140             


Leu Ile  Glu Asn Lys 
    1145             


