                         SEQUENCE LISTING

<110>  UMC Utrecht Holding B.V.
 
<120>  Targeted Thrombolysis for Treatment of Microvascular Thrombosis

<130>  P6074456PCT

<150>  18164232.3
<151>  2018-03-27

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hmUPA

<400>  1

Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile 
1               5                   10                  15      


Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala 
            20                  25                  30          


Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly 
        35                  40                  45              


Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile 
    50                  55                  60                  


Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg 
65                  70                  75                  80  


Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu 
                85                  90                  95      


Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp 
            100                 105                 110         


Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro 
        115                 120                 125             


Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro 
    130                 135                 140                 


Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser 
145                 150                 155                 160 


Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu 
                165                 170                 175     


Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val 
            180                 185                 190         


Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser 
        195                 200                 205             


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg 
    210                 215                 220                 


Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys 
225                 230                 235                 240 


Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile 
                245                 250                 255     


Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            260                 265             


<210>  2
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mmUPA

<400>  2

Gln Gly Phe Gln Cys Gly Gln Lys Ala Leu Arg Pro Arg Phe Lys Ile 
1               5                   10                  15      


Val Gly Gly Glu Phe Thr Glu Val Glu Asn Gln Pro Trp Phe Ala Ala 
            20                  25                  30          


Ile Tyr Gln Lys Asn Lys Gly Gly Ser Pro Pro Ser Phe Lys Cys Gly 
        35                  40                  45              


Gly Ser Leu Ile Ser Pro Cys Trp Val Ala Ser Ala Ala His Cys Phe 
    50                  55                  60                  


Ile Gln Leu Pro Lys Lys Glu Asn Tyr Val Val Tyr Leu Gly Gln Ser 
65                  70                  75                  80  


Lys Glu Ser Ser Tyr Asn Pro Gly Glu Met Lys Phe Glu Val Glu Gln 
                85                  90                  95      


Leu Ile Leu His Glu Tyr Tyr Arg Glu Asp Ser Leu Ala Tyr His Asn 
            100                 105                 110         


Asp Ile Ala Leu Leu Lys Ile Arg Thr Ser Thr Gly Gln Cys Ala Gln 
        115                 120                 125             


Pro Ser Arg Ser Ile Gln Thr Ile Cys Leu Pro Pro Arg Phe Thr Asp 
    130                 135                 140                 


Ala Pro Phe Gly Ser Asp Cys Glu Ile Thr Gly Phe Gly Lys Glu Ser 
145                 150                 155                 160 


Glu Ser Asp Tyr Leu Tyr Pro Lys Asn Leu Lys Met Ser Val Val Lys 
                165                 170                 175     


Leu Val Ser His Glu Gln Cys Met Gln Pro His Tyr Tyr Gly Ser Glu 
            180                 185                 190         


Ile Asn Tyr Lys Met Leu Cys Ala Ala Asp Pro Glu Trp Lys Thr Asp 
        195                 200                 205             


Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Cys Asn Ile Glu Gly 
    210                 215                 220                 


Arg Pro Thr Leu Ser Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Glu 
225                 230                 235                 240 


Lys Asn Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Asp Trp 
                245                 250                 255     


Ile Gln Ser His Ile Gly Glu Glu Lys Gly Leu Ala Phe 
            260                 265                 


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretion signal peptide

<400>  3

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  4
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP

<400>  4

Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Ser Ser Ala 
1               5                   10                  15      


Trp Ser His Pro Gln Phe Glu Lys 
            20                  


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV

<400>  5

Glu Phe Glu Asn Leu Tyr Phe Gln Ser 
1               5                   


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  6

Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala 
1               5                   10                  15      


<210>  7
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sVWF-hmUPA

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Thr Phe Ser Ser Asn Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr 
            100                 105                 110         


Tyr Tyr Leu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Gly Ser Ala Gly Leu Gly Tyr Val Gly 
145                 150                 155                 160 


Asp Pro Asp Ala Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val 
                165                 170                 175     


Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            180                 185                 190         


Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 
        195                 200                 205             


Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 
    210                 215                 220                 


Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 
225                 230                 235                 240 


Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 
                245                 250                 255     


Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 
            260                 265                 270         


Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 
        275                 280                 285             


Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 
    290                 295                 300                 


Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 
305                 310                 315                 320 


Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 
                325                 330                 335     


Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 
            340                 345                 350         


Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 
        355                 360                 365             


Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 
    370                 375                 380                 


Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 
385                 390                 395                 400 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 
                405                 410                 415     


Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 
            420                 425                 430         


Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 
        435                 440                 445             


Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460         


<210>  8
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D3-hmUPA

<400>  8

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Gln Thr Leu Ser Asn Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Glu Phe Val Ala Val Ile Ser Arg Val Gly Gly Ser Thr 
            100                 105                 110         


Ser Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Ala Ala Tyr Thr Ile Ala Val Val Thr 
145                 150                 155                 160 


Ala Met Arg Glu Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val 
                165                 170                 175     


Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            180                 185                 190         


Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 
        195                 200                 205             


Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 
    210                 215                 220                 


Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 
225                 230                 235                 240 


Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 
                245                 250                 255     


Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 
            260                 265                 270         


Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 
        275                 280                 285             


Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 
    290                 295                 300                 


Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 
305                 310                 315                 320 


Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 
                325                 330                 335     


Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 
            340                 345                 350         


Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 
        355                 360                 365             


Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 
    370                 375                 380                 


Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 
385                 390                 395                 400 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 
                405                 410                 415     


Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 
            420                 425                 430         


Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 
        435                 440                 445             


Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460         


<210>  9
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2-hmUPA

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Ala Thr Ser Gly His Gly His Tyr Gly Met Gly Trp Phe Arg Gln 
                85                  90                  95      


Val Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Arg Trp Ser Gly 
            100                 105                 110         


Lys Glu Thr Trp Tyr Lys Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
    130                 135                 140                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Pro Val Arg Val 
145                 150                 155                 160 


Asp Asp Ile Ser Leu Pro Val Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
                165                 170                 175     


Gln Val Thr Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Ala Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu 
        195                 200                 205             


Arg Pro Arg Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn 
    210                 215                 220                 


Gln Pro Trp Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val 
225                 230                 235                 240 


Thr Tyr Val Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser 
                245                 250                 255     


Ala Thr His Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val 
            260                 265                 270         


Tyr Leu Gly Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys 
        275                 280                 285             


Phe Glu Val Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr 
    290                 295                 300                 


Leu Ala His His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu 
305                 310                 315                 320 


Gly Arg Cys Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro 
                325                 330                 335     


Ser Met Tyr Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly 
            340                 345                 350         


Phe Gly Lys Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys 
        355                 360                 365             


Met Thr Val Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His 
    370                 375                 380                 


Tyr Tyr Gly Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro 
385                 390                 395                 400 


Gln Trp Lys Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
                405                 410                 415     


Cys Ser Leu Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly 
            420                 425                 430         


Arg Gly Cys Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser 
        435                 440                 445             


His Phe Leu Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu 
    450                 455                 460                 


Ala Leu 
465     


<210>  10
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A11-hmUPA

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Ala Val Gln Leu Val Glu Ser Gly Gly Arg 
    50                  55                  60                  


Leu Val Lys Ala Gly Ala Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Thr Phe Ser Ser Leu Pro Met Ala Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Glu Phe Val Ala Phe Ile Gly Ser Asp Ser Ser Thr Leu 
            100                 105                 110         


Tyr Thr Ser Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
        115                 120                 125             


Lys Asn Thr Val Tyr Leu Gln Met Met Asn Leu Lys Pro Glu Asp Thr 
    130                 135                 140                 


Ala Val Tyr Tyr Cys Ala Ala Arg Ser Ser Ala Phe Ser Ser Gly Ile 
145                 150                 155                 160 


Tyr Tyr Arg Glu Gly Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val 
                165                 170                 175     


Thr Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Ala Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro 
        195                 200                 205             


Arg Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro 
    210                 215                 220                 


Trp Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr 
225                 230                 235                 240 


Val Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr 
                245                 250                 255     


His Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu 
            260                 265                 270         


Gly Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu 
        275                 280                 285             


Val Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala 
    290                 295                 300                 


His His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg 
305                 310                 315                 320 


Cys Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met 
                325                 330                 335     


Tyr Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly 
            340                 345                 350         


Lys Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr 
        355                 360                 365             


Val Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr 
    370                 375                 380                 


Gly Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp 
385                 390                 395                 400 


Lys Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser 
                405                 410                 415     


Leu Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly 
            420                 425                 430         


Cys Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe 
        435                 440                 445             


Leu Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460                 


<210>  11
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A12-hmUPA

<400>  11

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
65                  70                  75                  80  


Arg Thr Phe Ser Thr Tyr Ala Leu Gly Trp Phe Arg Gln Val Pro Gly 
                85                  90                  95      


Lys Gly Arg Glu Phe Ile Ala Val Ile Tyr Trp Arg Asp Gly Ser Ser 
            100                 105                 110         


Leu Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn 
        115                 120                 125             


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Asn Arg His Asp Ser Arg Gly Thr Tyr 
145                 150                 155                 160 


Tyr Ser Ser Arg Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
                165                 170                 175     


Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         


Ala Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
        195                 200                 205             


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
    210                 215                 220                 


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
225                 230                 235                 240 


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
                245                 250                 255     


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
            260                 265                 270         


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
        275                 280                 285             


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
    290                 295                 300                 


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
305                 310                 315                 320 


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
                325                 330                 335     


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
            340                 345                 350         


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
        355                 360                 365             


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
    370                 375                 380                 


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
385                 390                 395                 400 


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
                405                 410                 415     


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
            420                 425                 430         


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
        435                 440                 445             


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460             


<210>  12
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GP1B-17 hmUPA

<400>  12

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp 
65                  70                  75                  80  


Ile Phe Ser Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
                85                  90                  95      


Gln Arg Glu Leu Val Ala Ser Ile Thr Arg Gly Gly Asp Pro Trp Tyr 
            100                 105                 110         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Lys 
        115                 120                 125             


Asn Ala Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
    130                 135                 140                 


Asp Thr Ala Val Tyr Tyr Cys Asn Ala Met Gly Ile Arg Gly Ser Gly 
145                 150                 155                 160 


Gly Asp Tyr Ala Arg Glu Ala Gly Gly Gln Gly Thr Gln Val Thr Val 
                165                 170                 175     


Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            180                 185                 190         


Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 
        195                 200                 205             


Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 
    210                 215                 220                 


Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 
225                 230                 235                 240 


Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 
                245                 250                 255     


Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 
            260                 265                 270         


Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 
        275                 280                 285             


Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 
    290                 295                 300                 


Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 
305                 310                 315                 320 


Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 
                325                 330                 335     


Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 
            340                 345                 350         


Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 
        355                 360                 365             


Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 
    370                 375                 380                 


Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 
385                 390                 395                 400 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 
                405                 410                 415     


Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 
            420                 425                 430         


Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 
        435                 440                 445             


Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460         


<210>  13
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A5

<400>  13

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Ala Ser Gly Arg Ile Phe Ser Ile Gly 
            20                  25                  30          


Ala Met Gly Met Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Pro Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Pro Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asn Leu Lys Gln Gly Ser Tyr Gly Tyr Arg Phe Asn Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A5H1

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Ser Ile Gly 
            20                  25                  30          


Ala Met Gly Met Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Pro Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Pro Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asn Leu Lys Gln Gly Ser Tyr Gly Tyr Arg Phe Asn Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2-mmUPA

<400>  15

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Ala Thr Ser Gly His Gly His Tyr Gly Met Gly Trp Phe Arg Gln 
                85                  90                  95      


Val Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Arg Trp Ser Gly 
            100                 105                 110         


Lys Glu Thr Trp Tyr Lys Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
    130                 135                 140                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Pro Val Arg Val 
145                 150                 155                 160 


Asp Asp Ile Ser Leu Pro Val Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
                165                 170                 175     


Gln Val Thr Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Ala Ala Ala Gln Gly Phe Gln Cys Gly Gln Lys Ala Leu 
        195                 200                 205             


Arg Pro Arg Phe Lys Ile Val Gly Gly Glu Phe Thr Glu Val Glu Asn 
    210                 215                 220                 


Gln Pro Trp Phe Ala Ala Ile Tyr Gln Lys Asn Lys Gly Gly Ser Pro 
225                 230                 235                 240 


Pro Ser Phe Lys Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ala 
                245                 250                 255     


Ser Ala Ala His Cys Phe Ile Gln Leu Pro Lys Lys Glu Asn Tyr Val 
            260                 265                 270         


Val Tyr Leu Gly Gln Ser Lys Glu Ser Ser Tyr Asn Pro Gly Glu Met 
        275                 280                 285             


Lys Phe Glu Val Glu Gln Leu Ile Leu His Glu Tyr Tyr Arg Glu Asp 
    290                 295                 300                 


Ser Leu Ala Tyr His Asn Asp Ile Ala Leu Leu Lys Ile Arg Thr Ser 
305                 310                 315                 320 


Thr Gly Gln Cys Ala Gln Pro Ser Arg Ser Ile Gln Thr Ile Cys Leu 
                325                 330                 335     


Pro Pro Arg Phe Thr Asp Ala Pro Phe Gly Ser Asp Cys Glu Ile Thr 
            340                 345                 350         


Gly Phe Gly Lys Glu Ser Glu Ser Asp Tyr Leu Tyr Pro Lys Asn Leu 
        355                 360                 365             


Lys Met Ser Val Val Lys Leu Val Ser His Glu Gln Cys Met Gln Pro 
    370                 375                 380                 


His Tyr Tyr Gly Ser Glu Ile Asn Tyr Lys Met Leu Cys Ala Ala Asp 
385                 390                 395                 400 


Pro Glu Trp Lys Thr Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu 
                405                 410                 415     


Ile Cys Asn Ile Glu Gly Arg Pro Thr Leu Ser Gly Ile Val Ser Trp 
            420                 425                 430         


Gly Arg Gly Cys Ala Glu Lys Asn Lys Pro Gly Val Tyr Thr Arg Val 
        435                 440                 445             


Ser His Phe Leu Asp Trp Ile Gln Ser His Ile Gly Glu Glu Lys Gly 
    450                 455                 460                 


Leu Ala Phe 
465         


<210>  16
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human uPA connecting peptide

<400>  16

Ala Asp Gly Lys Lys Pro Ser Ser Pro Pro Glu Glu Leu Lys Phe Gln 
1               5                   10                  15      


Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys 
            20                  25          


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human tPA connecting peptide

<400>  17

Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Arg 
1               5                   10                  


<210>  18
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human plasminogen connecting peptide

<400>  18

Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys Pro 
1               5                   10                  15      


Gly Arg 
        


<210>  19
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA catalytic domain

<400>  19

Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe Arg Ile Lys 
1               5                   10                  15      


Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala Ala Ile 
            20                  25                  30          


Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly Gly 
        35                  40                  45              


Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe Gln 
    50                  55                  60                  


Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr Tyr 
65                  70                  75                  80  


Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu Lys Tyr 
                85                  90                  95      


Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile Ala 
            100                 105                 110         


Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu Ser Ser 
        115                 120                 125             


Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu Pro Asp 
    130                 135                 140                 


Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu Ser 
145                 150                 155                 160 


Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu Tyr Pro 
                165                 170                 175     


Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val Thr Asp 
            180                 185                 190         


Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln Ala Asn 
        195                 200                 205             


Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Leu 
    210                 215                 220                 


Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu Gly 
225                 230                 235                 240 


Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn Tyr 
                245                 250                 255     


Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
            260                 265     


<210>  20
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-1 - hmUPA

<400>  20

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Phe Thr Phe Ser Ser Tyr Trp Met Tyr Trp Val Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gly Leu Glu Trp Val Ser Ala Ile Asn Thr Gly Gly Gly Ser Thr 
            100                 105                 110         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Lys Asp Leu Pro Asn Ser Asp Ser Leu 
145                 150                 155                 160 


Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser 
                165                 170                 175     


Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Leu 
            180                 185                 190         


Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile Ile 
        195                 200                 205             


Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala Ile 
    210                 215                 220                 


Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly Ser 
225                 230                 235                 240 


Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile Asp 
                245                 250                 255     


Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg Leu 
            260                 265                 270         


Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu Ile 
        275                 280                 285             


Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp Ile 
    290                 295                 300                 


Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro Ser 
305                 310                 315                 320 


Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro Gln 
                325                 330                 335     


Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser Thr 
            340                 345                 350         


Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu Ile 
        355                 360                 365             


Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val Thr 
    370                 375                 380                 


Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser Cys 
385                 390                 395                 400 


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg Met 
                405                 410                 415     


Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys Asp 
            420                 425                 430         


Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile Arg 
        435                 440                 445             


Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 


<210>  21
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-2-hmUPA

<400>  21

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Thr Cys Val Gly Ser Asp 
65                  70                  75                  80  


Arg Thr Phe Ser Asn Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Gln Phe Val Ser Thr Ile Ser Arg His Gly Thr Ser Thr 
            100                 105                 110         


Ala Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Glu Asn Ile Val Tyr Leu Gln Met Asn Ser Leu Glu Pro Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Ala Arg Pro His Thr Gln His Tyr Val 
145                 150                 155                 160 


Arg Val Glu Ser Tyr Gly Val Trp Gly Gln Gly Thr Gln Val Thr Val 
                165                 170                 175     


Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            180                 185                 190         


Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 
        195                 200                 205             


Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 
    210                 215                 220                 


Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 
225                 230                 235                 240 


Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 
                245                 250                 255     


Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 
            260                 265                 270         


Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 
        275                 280                 285             


Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 
    290                 295                 300                 


Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 
305                 310                 315                 320 


Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 
                325                 330                 335     


Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 
            340                 345                 350         


Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 
        355                 360                 365             


Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 
    370                 375                 380                 


Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 
385                 390                 395                 400 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 
                405                 410                 415     


Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 
            420                 425                 430         


Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 
        435                 440                 445             


Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460         


<210>  22
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-3- hmUPA

<400>  22

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Ser Ile Asn Ser Ile Arg Ala Met Gly Trp Tyr Arg Gln Pro Pro Gly 
                85                  90                  95      


Lys Gln Arg Glu Leu Val Ala Thr Ile Thr Arg Asp Gly Arg Thr Asn 
            100                 105                 110         


Tyr Pro Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Ile Asp Asn Ala 
        115                 120                 125             


Arg Asn Thr Val Ser Leu Gln Arg Asn Ser Leu Lys Pro Glu Asp Thr 
    130                 135                 140                 


Ala Val Tyr Tyr Cys Val Ala Asp Trp Gly Glu Gly Tyr Leu Thr Arg 
145                 150                 155                 160 


Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Ala Ala Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Leu Lys Phe Gln 
            180                 185                 190         


Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile Ile Gly Gly Glu 
        195                 200                 205             


Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala Ile Tyr Arg Arg 
    210                 215                 220                 


His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly Ser Leu Ile Ser 
225                 230                 235                 240 


Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile Asp Tyr Pro Lys 
                245                 250                 255     


Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg Leu Asn Ser Asn 
            260                 265                 270         


Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu Ile Leu His Lys 
        275                 280                 285             


Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp Ile Ala Leu Leu 
    290                 295                 300                 


Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro Ser Arg Thr Ile 
305                 310                 315                 320 


Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro Gln Phe Gly Thr 
                325                 330                 335     


Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser Thr Asp Tyr Leu 
            340                 345                 350         


Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu Ile Ser His Arg 
        355                 360                 365             


Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val Thr Thr Lys Met 
    370                 375                 380                 


Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser Cys Gln Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg Met Thr Leu Thr 
                405                 410                 415     


Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys Asp Lys Pro Gly 
            420                 425                 430         


Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile Arg Ser His Thr 
        435                 440                 445             


Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455     


<210>  23
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-4 hmUPA

<400>  23

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu 
65                  70                  75                  80  


Thr Phe Ser Ile Arg Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
                85                  90                  95      


Gln Arg Glu Leu Val Ala Tyr Ile Thr Ser Gly Gly Ser Thr Asn Tyr 
            100                 105                 110         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Arg 
        115                 120                 125             


Asn Thr Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
    130                 135                 140                 


Val Tyr Tyr Cys Tyr Gln Ala Pro Arg Ser Gly Tyr Asp Pro Val Tyr 
145                 150                 155                 160 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Ala Ala Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Leu Lys Phe Gln Cys 
            180                 185                 190         


Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile Ile Gly Gly Glu Phe 
        195                 200                 205             


Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala Ile Tyr Arg Arg His 
    210                 215                 220                 


Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly Ser Leu Ile Ser Pro 
225                 230                 235                 240 


Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile Asp Tyr Pro Lys Lys 
                245                 250                 255     


Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg Leu Asn Ser Asn Thr 
            260                 265                 270         


Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu Ile Leu His Lys Asp 
        275                 280                 285             


Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp Ile Ala Leu Leu Lys 
    290                 295                 300                 


Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro Ser Arg Thr Ile Gln 
305                 310                 315                 320 


Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro Gln Phe Gly Thr Ser 
                325                 330                 335     


Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser Thr Asp Tyr Leu Tyr 
            340                 345                 350         


Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu Ile Ser His Arg Glu 
        355                 360                 365             


Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val Thr Thr Lys Met Leu 
    370                 375                 380                 


Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser Cys Gln Gly Asp Ser 
385                 390                 395                 400 


Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg Met Thr Leu Thr Gly 
                405                 410                 415     


Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys Asp Lys Pro Gly Val 
            420                 425                 430         


Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile Arg Ser His Thr Lys 
        435                 440                 445             


Glu Glu Asn Gly Leu Ala Leu 
    450                 455 


<210>  24
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-5 hmUPA

<400>  24

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu 
65                  70                  75                  80  


Phe Thr Phe Ser Lys His Trp Met Tyr Trp Val Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Leu Gly Gly Asp Ser Thr 
            100                 105                 110         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Lys Ser Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Lys Gly Ala Ser Ser Trp Phe Gly Asp 
145                 150                 155                 160 


Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Ala 
                165                 170                 175     


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Leu Lys 
            180                 185                 190         


Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile Ile Gly 
        195                 200                 205             


Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala Ile Tyr 
    210                 215                 220                 


Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly Ser Leu 
225                 230                 235                 240 


Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile Asp Tyr 
                245                 250                 255     


Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg Leu Asn 
            260                 265                 270         


Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu Ile Leu 
        275                 280                 285             


His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp Ile Ala 
    290                 295                 300                 


Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro Ser Arg 
305                 310                 315                 320 


Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro Gln Phe 
                325                 330                 335     


Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser Thr Asp 
            340                 345                 350         


Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu Ile Ser 
        355                 360                 365             


His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val Thr Thr 
    370                 375                 380                 


Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser Cys Gln 
385                 390                 395                 400 


Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg Met Thr 
                405                 410                 415     


Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys Asp Lys 
            420                 425                 430         


Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile Arg Ser 
        435                 440                 445             


His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455             


<210>  25
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-6 hmUPA

<400>  25

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Phe Thr Phe Ser Asn Phe Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gly Leu Glu Trp Val Ser Phe Ile Asn Arg Gly Gly Gly Ser Thr 
            100                 105                 110         


Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Lys Phe Ser Arg Ser Val Pro Pro Tyr 
145                 150                 155                 160 


Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
                165                 170                 175     


Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala 
            180                 185                 190         


Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile 
        195                 200                 205             


Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala 
    210                 215                 220                 


Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly 
225                 230                 235                 240 


Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile 
                245                 250                 255     


Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg 
            260                 265                 270         


Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu 
        275                 280                 285             


Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp 
    290                 295                 300                 


Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro 
305                 310                 315                 320 


Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro 
                325                 330                 335     


Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser 
            340                 345                 350         


Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu 
        355                 360                 365             


Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val 
    370                 375                 380                 


Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser 
385                 390                 395                 400 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg 
                405                 410                 415     


Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys 
            420                 425                 430         


Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile 
        435                 440                 445             


Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460 


<210>  26
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1 - 7 hmUPA

<400>  26

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Val Asp Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                85                  90                  95      


Glu Phe Val Ala Thr Ile Thr Trp Ser Asp Ser Lys Ile Tyr Tyr Ala 
            100                 105                 110         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gly Glu Arg Ala Lys Asn 
        115                 120                 125             


Thr Met Tyr Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Val 
    130                 135                 140                 


Tyr Tyr Cys Ala Ala Ala His Arg Pro Tyr Arg Ser Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Met Gln Ser Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                165                 170                 175     


Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            180                 185                 190         


Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 
        195                 200                 205             


Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 
    210                 215                 220                 


Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 
225                 230                 235                 240 


Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 
                245                 250                 255     


Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 
            260                 265                 270         


Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 
        275                 280                 285             


Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 
    290                 295                 300                 


Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 
305                 310                 315                 320 


Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 
                325                 330                 335     


Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 
            340                 345                 350         


Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 
        355                 360                 365             


Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 
    370                 375                 380                 


Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 
385                 390                 395                 400 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 
                405                 410                 415     


Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 
            420                 425                 430         


Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 
        435                 440                 445             


Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460         


<210>  27
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-8 hmUPA

<400>  27

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Ser 
65                  70                  75                  80  


Met Phe Ser Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Arg 
                85                  90                  95      


Gln Arg Glu Leu Val Ala Thr Ile Thr Ser Gly Asp Ser Thr Tyr Tyr 
            100                 105                 110         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        115                 120                 125             


Tyr Thr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
    130                 135                 140                 


Asp Thr Ala Val Tyr Tyr Cys Asn Ala Ala His Ile Arg Gly Ser Gly 
145                 150                 155                 160 


Gly Asp Tyr Ala Arg Glu Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
                165                 170                 175     


Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            180                 185                 190         


Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 
        195                 200                 205             


Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 
    210                 215                 220                 


Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 
225                 230                 235                 240 


Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 
                245                 250                 255     


Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 
            260                 265                 270         


Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 
        275                 280                 285             


Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 
    290                 295                 300                 


Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 
305                 310                 315                 320 


Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 
                325                 330                 335     


Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 
            340                 345                 350         


Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 
        355                 360                 365             


Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 
    370                 375                 380                 


Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 
385                 390                 395                 400 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 
                405                 410                 415     


Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 
            420                 425                 430         


Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 
        435                 440                 445             


Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460         


<210>  28
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-9 hmUPA

<400>  28

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Pro Thr Val Ser Asn Tyr Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Asp Phe Val Ala Gly Ile Ser Arg Ser Gly Val Glu Lys 
            100                 105                 110         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Leu Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    130                 135                 140                 


Thr Ala Ala Tyr Tyr Cys Ala Ala Arg Glu Arg Val Gly Ile Thr Phe 
145                 150                 155                 160 


Ala His Ser Thr Val Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
                165                 170                 175     


Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            180                 185                 190         


Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 
        195                 200                 205             


Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 
    210                 215                 220                 


Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 
225                 230                 235                 240 


Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 
                245                 250                 255     


Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 
            260                 265                 270         


Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 
        275                 280                 285             


Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 
    290                 295                 300                 


Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 
305                 310                 315                 320 


Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 
                325                 330                 335     


Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 
            340                 345                 350         


Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 
        355                 360                 365             


Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 
    370                 375                 380                 


Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 
385                 390                 395                 400 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 
                405                 410                 415     


Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 
            420                 425                 430         


Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 
        435                 440                 445             


Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460         


<210>  29
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-10 hmUPA

<400>  29

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Phe Thr Phe Ser Lys Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gly Leu Glu Trp Val Ser Ile Ile Asp Ser Gly Gly Gly Ala Ile 
            100                 105                 110         


Gly Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Val Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr His Cys Val Phe Gly Asp Tyr Lys Gly Gln Gly Thr 
145                 150                 155                 160 


Gln Val Thr Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Ala Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu 
            180                 185                 190         


Arg Pro Arg Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn 
        195                 200                 205             


Gln Pro Trp Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val 
    210                 215                 220                 


Thr Tyr Val Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser 
225                 230                 235                 240 


Ala Thr His Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val 
                245                 250                 255     


Tyr Leu Gly Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys 
            260                 265                 270         


Phe Glu Val Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr 
        275                 280                 285             


Leu Ala His His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu 
    290                 295                 300                 


Gly Arg Cys Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro 
305                 310                 315                 320 


Ser Met Tyr Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly 
                325                 330                 335     


Phe Gly Lys Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys 
            340                 345                 350         


Met Thr Val Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His 
        355                 360                 365             


Tyr Tyr Gly Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro 
    370                 375                 380                 


Gln Trp Lys Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
385                 390                 395                 400 


Cys Ser Leu Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly 
                405                 410                 415     


Arg Gly Cys Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser 
            420                 425                 430         


His Phe Leu Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu 
        435                 440                 445             


Ala Leu 
    450 


<210>  30
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-11 hmUPA

<400>  30

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Phe Thr Phe Ser Ser Ser Ala Met Thr Trp Val Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gly Leu Glu Trp Val Ser Ala Ile Asn Ser Gly Gly Ser Gly Thr 
            100                 105                 110         


Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Lys Arg Arg Asp Gly Gln Asn Trp Tyr 
145                 150                 155                 160 


Pro Gly Ile Ser Tyr Glu Ser Met Tyr Arg Gly Gln Gly Thr Gln Val 
                165                 170                 175     


Thr Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Ala Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro 
        195                 200                 205             


Arg Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro 
    210                 215                 220                 


Trp Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr 
225                 230                 235                 240 


Val Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr 
                245                 250                 255     


His Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu 
            260                 265                 270         


Gly Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu 
        275                 280                 285             


Val Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala 
    290                 295                 300                 


His His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg 
305                 310                 315                 320 


Cys Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met 
                325                 330                 335     


Tyr Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly 
            340                 345                 350         


Lys Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr 
        355                 360                 365             


Val Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr 
    370                 375                 380                 


Gly Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp 
385                 390                 395                 400 


Lys Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser 
                405                 410                 415     


Leu Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly 
            420                 425                 430         


Cys Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe 
        435                 440                 445             


Leu Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460                 


<210>  31
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-12 hmUPA

<400>  31

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Thr Phe Ser Ser Tyr Thr Met Ala Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Glu Phe Val Gly Leu Ile Ser Trp Asn Ala Lys Ser Thr 
            100                 105                 110         


Tyr Val Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Arg Glu Asn 
        115                 120                 125             


Ala Lys Asp Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    130                 135                 140                 


Ser Ala Thr Tyr Tyr Cys Ala Ala Asn Arg Tyr Gly Ser Ser Val Pro 
145                 150                 155                 160 


Gly Ala Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                165                 170                 175     


Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala 
            180                 185                 190         


Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile 
        195                 200                 205             


Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala 
    210                 215                 220                 


Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly 
225                 230                 235                 240 


Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile 
                245                 250                 255     


Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg 
            260                 265                 270         


Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu 
        275                 280                 285             


Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp 
    290                 295                 300                 


Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro 
305                 310                 315                 320 


Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro 
                325                 330                 335     


Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser 
            340                 345                 350         


Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu 
        355                 360                 365             


Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val 
    370                 375                 380                 


Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser 
385                 390                 395                 400 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg 
                405                 410                 415     


Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys 
            420                 425                 430         


Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile 
        435                 440                 445             


Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460 


<210>  32
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-13 hmUPA

<400>  32

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Phe Thr Phe Ser Ser Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gly Leu Glu Trp Val Ser Ala Ile Asn Met Gly Gly Gly Ser Thr 
            100                 105                 110         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Gly Leu Lys Pro Glu Asp 
    130                 135                 140                 


Thr Ala Leu Tyr Tyr Cys Val Arg Gly Gly Ser Ala Tyr Ser Val Arg 
145                 150                 155                 160 


Tyr Glu Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                165                 170                 175     


Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala 
            180                 185                 190         


Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile 
        195                 200                 205             


Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala 
    210                 215                 220                 


Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly 
225                 230                 235                 240 


Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile 
                245                 250                 255     


Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg 
            260                 265                 270         


Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu 
        275                 280                 285             


Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp 
    290                 295                 300                 


Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro 
305                 310                 315                 320 


Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro 
                325                 330                 335     


Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser 
            340                 345                 350         


Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu 
        355                 360                 365             


Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val 
    370                 375                 380                 


Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser 
385                 390                 395                 400 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg 
                405                 410                 415     


Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys 
            420                 425                 430         


Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile 
        435                 440                 445             


Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460 


<210>  33
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1-14 hmUPA

<400>  33

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ala Ala 
65                  70                  75                  80  


Ser Trp Phe Ser Ile Tyr Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gln Arg Glu Leu Val Ala Ile Ile Leu Ser Asp Gly Asp Thr Asp 
            100                 105                 110         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        115                 120                 125             


Lys Asn Thr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    130                 135                 140                 


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Arg Gly Ile Arg Gly Ser 
145                 150                 155                 160 


Gly Gly Asp Tyr Ala Arg Glu Ala Trp Gly Gln Gly Thr Gln Val Thr 
                165                 170                 175     


Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         


Ala Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
        195                 200                 205             


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
    210                 215                 220                 


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
225                 230                 235                 240 


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
                245                 250                 255     


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
            260                 265                 270         


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
        275                 280                 285             


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
    290                 295                 300                 


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
305                 310                 315                 320 


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
                325                 330                 335     


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
            340                 345                 350         


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
        355                 360                 365             


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
    370                 375                 380                 


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
385                 390                 395                 400 


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
                405                 410                 415     


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
            420                 425                 430         


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
        435                 440                 445             


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460             


<210>  34
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   GPB1- 15 hmUPA

<400>  34

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Ser Met Phe Ser Ile Asn Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gln Arg Glu Leu Val Ala Thr Ile Thr Arg Gly Gly Asn Thr Tyr 
            100                 105                 110         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        115                 120                 125             


Thr Tyr Thr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    130                 135                 140                 


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Arg His Ile Arg Gly Ser 
145                 150                 155                 160 


Gly Gly Asp Tyr Ala Arg Glu Ala Trp Gly Gln Gly Thr Gln Val Thr 
                165                 170                 175     


Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         


Ala Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
        195                 200                 205             


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
    210                 215                 220                 


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
225                 230                 235                 240 


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
                245                 250                 255     


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
            260                 265                 270         


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
        275                 280                 285             


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
    290                 295                 300                 


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
305                 310                 315                 320 


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
                325                 330                 335     


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
            340                 345                 350         


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
        355                 360                 365             


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
    370                 375                 380                 


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
385                 390                 395                 400 


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
                405                 410                 415     


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
            420                 425                 430         


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
        435                 440                 445             


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460             


<210>  35
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1- 16 hmUPA

<400>  35

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg 
65                  70                  75                  80  


Arg Thr Phe Ser Asn Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Glu Ser Val Thr Ala Ile Gly Arg Ser Gly Thr Ile Leu 
            100                 105                 110         


Tyr Ala Asp Ser Met Lys Gly Arg Ile Thr Ile Ser Arg Asp Asn Ala 
        115                 120                 125             


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Thr Pro Asp Asp Thr 
    130                 135                 140                 


Ala Val Tyr Tyr Cys Ala Ala Ser Ser Gly Ser Met Gln Gln Phe Trp 
145                 150                 155                 160 


Arg Met Glu Tyr Asp Tyr Glu Gly Gln Gly Thr Gln Val Thr Val Ser 
                165                 170                 175     


Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala 
            180                 185                 190         


Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys 
        195                 200                 205             


Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala 
    210                 215                 220                 


Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly 
225                 230                 235                 240 


Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe 
                245                 250                 255     


Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser 
            260                 265                 270         


Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn 
        275                 280                 285             


Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn 
    290                 295                 300                 


Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln 
305                 310                 315                 320 


Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp 
                325                 330                 335     


Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn 
            340                 345                 350         


Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys 
        355                 360                 365             


Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu 
    370                 375                 380                 


Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp 
385                 390                 395                 400 


Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly 
                405                 410                 415     


Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu 
            420                 425                 430         


Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp 
        435                 440                 445             


Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460     


<210>  36
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1- 19 hmUPA

<400>  36

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Thr Phe Gly Ser Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Glu Phe Val Ala Ala Ile Gly Arg Ser Gly Thr Thr Tyr 
            100                 105                 110         


Tyr Leu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        115                 120                 125             


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
    130                 135                 140                 


Ala Val Tyr Tyr Cys Gly Ala Ser Leu Lys Gly Thr Val Leu Gly Ile 
145                 150                 155                 160 


Ala Arg Tyr Glu Tyr Asp Val Arg Gly Gln Gly Thr Gln Val Thr Val 
                165                 170                 175     


Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
            180                 185                 190         


Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 
        195                 200                 205             


Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 
    210                 215                 220                 


Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 
225                 230                 235                 240 


Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 
                245                 250                 255     


Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 
            260                 265                 270         


Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 
        275                 280                 285             


Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 
    290                 295                 300                 


Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 
305                 310                 315                 320 


Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 
                325                 330                 335     


Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 
            340                 345                 350         


Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 
        355                 360                 365             


Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 
    370                 375                 380                 


Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 
385                 390                 395                 400 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 
                405                 410                 415     


Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 
            420                 425                 430         


Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 
        435                 440                 445             


Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
    450                 455                 460         


<210>  37
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPB1- 20 hmUPA

<400>  37

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Thr Leu Ser Ser Leu Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Glu Phe Val Ala Ala Asp Arg Arg Asn Gly Gly Tyr Thr 
            100                 105                 110         


Val Val Ala Asp Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Phe 
        115                 120                 125             


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys 
    130                 135                 140                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Ser Asp Arg Thr 
145                 150                 155                 160 


Met Ser Leu Arg Ser Thr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
                165                 170                 175     


Val Thr Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Ala Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg 
        195                 200                 205             


Pro Arg Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln 
    210                 215                 220                 


Pro Trp Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr 
225                 230                 235                 240 


Tyr Val Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala 
                245                 250                 255     


Thr His Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr 
            260                 265                 270         


Leu Gly Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe 
        275                 280                 285             


Glu Val Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu 
    290                 295                 300                 


Ala His His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly 
305                 310                 315                 320 


Arg Cys Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser 
                325                 330                 335     


Met Tyr Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe 
            340                 345                 350         


Gly Lys Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met 
        355                 360                 365             


Thr Val Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr 
    370                 375                 380                 


Tyr Gly Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln 
385                 390                 395                 400 


Trp Lys Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
                405                 410                 415     


Ser Leu Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg 
            420                 425                 430         


Gly Cys Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His 
        435                 440                 445             


Phe Leu Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala 
    450                 455                 460                 


Leu 
465 


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker

<400>  38

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker

<400>  39

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  40
<211>  791
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dsDNA

<400>  40
ggatccgaag tccagcttgt agaatcagga ggaggccttg tccagccagg tggtagcctt       60

cgtctgtcgt gtgctgcttc gggccgcaca ttttcgtata accctatggg ttggtttcgc      120

caagcacccg gcaagggacg cgagttggtg gccgcgatta gtcgtacggg tggttccacc      180

tactacccgg attcagtgga aggacgcttt acgattagcc gtgataacgc gaagcgtatg      240

gtctacttac agatgaatag cttgcgcgcg gaagacaccg cggtatacta ttgtgctgca      300

gcaggagtcc gtgctgagga tggacgcgtc cgcacgttac ctagtgagta tacattctgg      360

ggccagggca cccaagttac cgtatccagt gcagcagcgg aagtacaact ggtcgaatct      420

ggaggaggac ttgtacaacc agggggttcc ttacgtttgt catgtgcggc aagtgggcgc      480

acatttagtt acaaccctat gggctggttc cgtcaagccc cgggaaaagg gcgcgaactt      540

gtagccgcca tttcgcgtac agggggaagt acctattacc cggactcagt agagggacgc      600

ttcacgattt ctcgtgacaa cgcaaagcgc atggtttatc tgcaaatgaa tagtttacgc      660

gccgaagata cagcagttta ctattgcgcc gcagctggag tccgcgccga agacggccgt      720

gtacgcacct tgccttctga atacactttt tggggtcaag gaacacaggt gaccgtgtca      780

tctgcggccg c                                                           791


<210>  41
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caplacizumab in pTH4.0 protein sequence

<400>  41

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Gln Ser Gly His His His His His His His 
            20                  25                  30          


His Asp Tyr Asp Ile Pro Ser Ser Glu Asn Leu Tyr Phe Gln Gly Ser 
        35                  40                  45              


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    50                  55                  60                  


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Tyr Asn 
65                  70                  75                  80  


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
                85                  90                  95      


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
            100                 105                 110         


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
        115                 120                 125             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    130                 135                 140                 


Ala Ala Ala Gly Val Arg Ala Glu Asp Gly Arg Val Arg Thr Leu Pro 
145                 150                 155                 160 


Ser Glu Tyr Thr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                165                 170                 175     


Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            180                 185                 190         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        195                 200                 205             


Ser Tyr Asn Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg 
    210                 215                 220                 


Glu Leu Val Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro 
225                 230                 235                 240 


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg 
                245                 250                 255     


Met Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            260                 265                 270         


Tyr Tyr Cys Ala Ala Ala Gly Val Arg Ala Glu Asp Gly Arg Val Arg 
        275                 280                 285             


Thr Leu Pro Ser Glu Tyr Thr Phe Trp Gly Gln Gly Thr Gln Val Thr 
    290                 295                 300                 


Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
305                 310                 315                 320 


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
taatacgact cactataggg                                                   20


<210>  43
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer Rv

<400>  43
gctagttatt gctcagcgg                                                    19


<210>  44
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cablivi-hmUPA

<400>  44

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Thr Phe Ser Tyr Asn Pro Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gly Arg Glu Leu Val Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr 
            100                 105                 110         


Tyr Tyr Pro Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Lys Arg Met Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Ala Ala Gly Val Arg Ala Glu Asp Gly 
145                 150                 155                 160 


Arg Val Arg Thr Leu Pro Ser Glu Tyr Thr Phe Trp Gly Gln Gly Thr 
                165                 170                 175     


Gln Val Thr Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Ala Ala Ala Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu 
        195                 200                 205             


Arg Pro Arg Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn 
    210                 215                 220                 


Gln Pro Trp Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val 
225                 230                 235                 240 


Thr Tyr Val Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser 
                245                 250                 255     


Ala Thr His Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val 
            260                 265                 270         


Tyr Leu Gly Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys 
        275                 280                 285             


Phe Glu Val Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr 
    290                 295                 300                 


Leu Ala His His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu 
305                 310                 315                 320 


Gly Arg Cys Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro 
                325                 330                 335     


Ser Met Tyr Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly 
            340                 345                 350         


Phe Gly Lys Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys 
        355                 360                 365             


Met Thr Val Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His 
    370                 375                 380                 


Tyr Tyr Gly Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro 
385                 390                 395                 400 


Gln Trp Lys Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
                405                 410                 415     


Cys Ser Leu Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly 
            420                 425                 430         


Arg Gly Cys Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser 
        435                 440                 445             


His Phe Leu Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu 
    450                 455                 460                 


Ala Leu 
465     


<210>  45
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   Cablivi-mmUPA

<400>  45

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Glu Phe Glu 
        35                  40                  45              


Asn Leu Tyr Phe Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    50                  55                  60                  


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
65                  70                  75                  80  


Arg Thr Phe Ser Tyr Asn Pro Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gly Arg Glu Leu Val Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr 
            100                 105                 110         


Tyr Tyr Pro Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        115                 120                 125             


Ala Lys Arg Met Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    130                 135                 140                 


Thr Ala Val Tyr Tyr Cys Ala Ala Ala Gly Val Arg Ala Glu Asp Gly 
145                 150                 155                 160 


Arg Val Arg Thr Leu Pro Ser Glu Tyr Thr Phe Trp Gly Gln Gly Thr 
                165                 170                 175     


Gln Val Thr Val Ser Ser Ser Ala Ala Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Ala Ala Ala Gln Gly Phe Gln Cys Gly Gln Lys Ala Leu 
        195                 200                 205             


Arg Pro Arg Phe Lys Ile Val Gly Gly Glu Phe Thr Glu Val Glu Asn 
    210                 215                 220                 


Gln Pro Trp Phe Ala Ala Ile Tyr Gln Lys Asn Lys Gly Gly Ser Pro 
225                 230                 235                 240 


Pro Ser Phe Lys Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ala 
                245                 250                 255     


Ser Ala Ala His Cys Phe Ile Gln Leu Pro Lys Lys Glu Asn Tyr Val 
            260                 265                 270         


Val Tyr Leu Gly Gln Ser Lys Glu Ser Ser Tyr Asn Pro Gly Glu Met 
        275                 280                 285             


Lys Phe Glu Val Glu Gln Leu Ile Leu 
    290                 295         


<210>  46
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cablivi VHH

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Tyr Asn 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Val Arg Ala Glu Asp Gly Arg Val Arg Thr Leu Pro 
            100                 105                 110         


Ser Glu Tyr Thr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


