                         SEQUENCE LISTING

<110>  Adagene Inc.
 
<120>  Anti-PD-L1 Antibodies and Use Thereof

<130>  F19W0502PCT

<150>  PCT/CN2018/081096
<151>  2018-03-29

<160>  182   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = G or S

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = I or V

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = E, G or S

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = K, P or S

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = F, W or Y

<400>  1

Arg Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Leu Ala 
1               5                   10      


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = E or Q

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = F, H or Y

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa = I or K

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa = A or D

<400>  2

Arg Ala Ser Xaa Ser Val Asp Phe Xaa Gly Xaa Ser Phe Leu Xaa 
1               5                   10                  15  


<210>  3
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa = Q or R

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = D, S or T

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = K, S or T

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa = A or N

<400>  3

Xaa Ala Ser Gln Xaa Ile Pro Xaa Phe Leu Xaa 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = I or V

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = P or S

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = W or Y

<400>  4

Arg Ala Ser Gln Gly Xaa Ser Xaa Xaa Leu Ala 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = S or T

<400>  5

Arg Ala Ser Gln Xaa Ile Pro Ser Phe Leu Asn 
1               5                   10      


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = N or S

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = L or R

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = A or E

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = S or T

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = I or V

<400>  6

Asp Ala Ser Xaa Xaa Xaa Xaa Gly Xaa 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = S or T

<400>  7

Ala Ala Ser Xaa Leu Gln Ser Gly Val 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = L or R

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = A or E

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = I or V

<400>  8

Asp Ala Ser Asn Xaa Xaa Thr Gly Xaa 
1               5                   


<210>  9
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = A, H, S or Y

<400>  9

Tyr Cys Gln Gln Tyr Asp Xaa Trp Pro Tyr Thr 
1               5                   10      


<210>  10
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = H or Q

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = G, I, S, T or V

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa = G, L, Q, R or V

<400>  10

Tyr Cys Gln Xaa Tyr Xaa Ser Trp Pro Arg Xaa Phe Thr 
1               5                   10              


<210>  11
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = A or S

<400>  11

Tyr Cys Gln Gln Tyr Asp Xaa Trp Pro Tyr Thr 
1               5                   10      


<210>  12
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = I or T

<400>  12

Tyr Cys Gln His Tyr Xaa Ser Trp Pro Arg Gln Phe Thr 
1               5                   10              


<210>  13
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  13

Arg Ala Ser Gln Gly Ile Gly Ser Phe Leu Ala 
1               5                   10      


<210>  14
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  14

Arg Ala Ser Glu Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Asp 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  15

Arg Ala Ser Gln Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Ala 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  16

Arg Ala Ser Glu Ser Val Asp Phe Phe Gly Lys Ser Phe Leu Ala 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  17

Arg Ala Ser Gln Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Asp 
1               5                   10                  15  


<210>  18
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  18

Arg Ala Ser Gln Ser Val Ser Ser Trp Leu Ala 
1               5                   10      


<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  19

Arg Ala Ser Glu Ser Val Asp Phe Phe Gly Lys Ser Phe Leu Ala 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  20

Arg Ala Ser Glu Ser Val Asp Phe His Gly Ile Ser Phe Leu Ala 
1               5                   10                  15  


<210>  21
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  21

Arg Ala Ser Gln Ser Val Ser Pro Tyr Leu Ala 
1               5                   10      


<210>  22
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  22

Arg Ala Ser Gln Ser Val Gly Ser Ile Tyr Leu Gly 
1               5                   10          


<210>  23
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  23

Arg Ala Ser Gln Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Ala 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  24

Arg Ala Ser Glu Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Ala 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  25

Arg Ala Ser Gln Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Asp 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  26

Arg Ala Ser Glu Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Asp 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  27

Arg Ala Ser Glu Ser Val Asp Phe His Gly Lys Ser Phe Leu Ala 
1               5                   10                  15  


<210>  28
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  28

Arg Ala Ser Gln Gly Val Ser Pro Trp Leu Ala 
1               5                   10      


<210>  29
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  29

Arg Ala Ser Gln Ser Val Ser Pro Tyr Leu Ala 
1               5                   10      


<210>  30
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  30

Arg Ala Ser Gln Ser Val Asp Phe His Gly Lys Ser Phe Leu Asp 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  31

Arg Ala Ser Gln Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Ala 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  32

Arg Ala Ser Glu Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Ala 
1               5                   10                  15  


<210>  33
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  33

Arg Ala Ser Gln Ser Ile Glu Lys Trp Leu Ala 
1               5                   10      


<210>  34
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  34

Arg Ala Ser Gln Ser Val Asp Phe His Gly Ile Ser Phe Leu Asp 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  35

Arg Ala Ser Gln Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Asp 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  36

Arg Ala Ser Gln Ser Val Asp Phe His Gly Ile Ser Phe Leu Asp 
1               5                   10                  15  


<210>  37
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  37

Arg Ala Ser Gln Gly Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  38

Arg Ala Ser Gln Gly Ile Ser Pro Trp Leu Ala 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  39

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  40
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  40

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  41

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  42

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  43

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  44

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  45

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  46

Asp Ala Ser Asn Leu Glu Thr Gly Val 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  47

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  48

Asp Ala Ser Asn Leu Glu Thr Gly Val 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  49

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  50

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  51

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  52

Asp Ala Ser Asn Leu Glu Thr Gly Val 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  53

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  54

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  55

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  56

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  57

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  58

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  59

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  60

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  61

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  62

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  63

Asp Ala Ser Asn Leu Glu Thr Gly Val 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  64

Asp Ala Ser Asn Leu Glu Thr Gly Val 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  65

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  66

Asp Ala Ser Asn Leu Glu Thr Gly Val 
1               5                   


<210>  67
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  67

Tyr Cys Gln Gln Tyr Asp Tyr Trp Pro Tyr Thr 
1               5                   10      


<210>  68
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  68

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  69
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  69

Tyr Cys Gln Gln Tyr Asp His Trp Pro Tyr Thr 
1               5                   10      


<210>  70
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  70

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  71
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  71

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  72
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  72

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  73
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  73

Tyr Cys Gln Gln Tyr Asp His Trp Pro Tyr Thr 
1               5                   10      


<210>  74
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  74

Tyr Cys Gln Gln Tyr Asp His Trp Pro Tyr Thr 
1               5                   10      


<210>  75
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  75

Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr Thr 
1               5                   10      


<210>  76
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  76

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  77
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  77

Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr Thr 
1               5                   10      


<210>  78
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  78

Tyr Cys Gln Gln Tyr Asp Tyr Trp Pro Tyr Thr 
1               5                   10      


<210>  79
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  79

Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr Thr 
1               5                   10      


<210>  80
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  80

Tyr Cys Gln Gln Tyr Asp His Trp Pro Tyr Thr 
1               5                   10      


<210>  81
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  81

Tyr Cys Gln Gln Tyr Asp His Trp Pro Tyr Thr 
1               5                   10      


<210>  82
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  82

Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr Thr 
1               5                   10      


<210>  83
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  83

Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr Thr 
1               5                   10      


<210>  84
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  84

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  85
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  85

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  86
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  86

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  87
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  87

Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr Thr 
1               5                   10      


<210>  88
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  88

Tyr Cys Gln Gln Tyr Asp His Trp Pro Tyr Thr 
1               5                   10      


<210>  89
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  89

Tyr Cys Gln Gln Tyr Asp His Trp Pro Tyr Thr 
1               5                   10      


<210>  90
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  90

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  91
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  91

Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr Thr 
1               5                   10      


<210>  92
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  92

Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr Thr 
1               5                   10      


<210>  93
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  93

Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr Thr 
1               5                   10      


<210>  94
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  94

Gln Ala Ser Gln Asp Ile Pro Thr Phe Leu Ala 
1               5                   10      


<210>  95
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  95

Arg Ala Ser Gln Thr Ile Pro Ser Phe Leu Asn 
1               5                   10      


<210>  96
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  96

Arg Ala Ser Gln Asp Ile Pro Lys Phe Leu Ala 
1               5                   10      


<210>  97
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  97

Arg Ala Ser Gln Thr Ile Pro Ser Phe Leu Asn 
1               5                   10      


<210>  98
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  98

Arg Ala Ser Gln Ser Ile Pro Ser Phe Leu Asn 
1               5                   10      


<210>  99
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  99

Arg Ala Ser Gln Ser Ile Pro Thr Phe Leu Asn 
1               5                   10      


<210>  100
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  100

Arg Ala Ser Gln Ser Ile Pro Ser Phe Leu Asn 
1               5                   10      


<210>  101
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  101

Arg Ala Ser Gln Thr Ile Pro Ser Phe Leu Asn 
1               5                   10      


<210>  102
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  102

Arg Ala Ser Gln Thr Ile Pro Ser Phe Leu Asn 
1               5                   10      


<210>  103
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  103

Ala Ala Ser Ser Leu Gln Ser Gly Val 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  104

Ala Ala Ser Thr Leu Gln Ser Gly Val 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  105

Ala Ala Ser Thr Leu Gln Ser Gly Val 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  106

Ala Ala Ser Ser Leu Gln Ser Gly Val 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  107

Ala Ala Ser Thr Leu Gln Ser Gly Val 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  108

Ala Ala Ser Thr Leu Gln Ser Gly Val 
1               5                   


<210>  109
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  109

Ala Ala Ser Ser Leu Gln Ser Gly Val 
1               5                   


<210>  110
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  110

Ala Ala Ser Thr Leu Gln Ser Gly Val 
1               5                   


<210>  111
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  111

Ala Ala Ser Ser Leu Gln Ser Gly Val 
1               5                   


<210>  112
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  112

Tyr Cys Gln Gln Tyr Val Ser Trp Pro Arg Gly Phe Thr 
1               5                   10              


<210>  113
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  113

Tyr Cys Gln His Tyr Ser Ser Trp Pro Arg Gly Phe Thr 
1               5                   10              


<210>  114
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  114

Tyr Cys Gln His Tyr Val Ser Trp Pro Arg Gln Phe Thr 
1               5                   10              


<210>  115
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  115

Tyr Cys Gln His Tyr Thr Ser Trp Pro Arg Gln Phe Thr 
1               5                   10              


<210>  116
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  116

Tyr Cys Gln Gln Tyr Ser Ser Trp Pro Arg Leu Phe Thr 
1               5                   10              


<210>  117
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  117

Tyr Cys Gln His Tyr Val Ser Trp Pro Arg Leu Phe Thr 
1               5                   10              


<210>  118
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  118

Tyr Cys Gln His Tyr Ile Ser Trp Pro Arg Gln Phe Thr 
1               5                   10              


<210>  119
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  119

Tyr Cys Gln His Tyr Ile Ser Trp Pro Arg Val Phe Thr 
1               5                   10              


<210>  120
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  120

Tyr Cys Gln His Tyr Gly Ser Trp Pro Arg Arg Phe Thr 
1               5                   10              


<210>  121
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  Xaa = G or S

<220>
<221>  VARIANT
<222>  (29)..(29)
<223>  Xaa = I or V

<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  Xaa = E, G or S

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Xaa = K, P or S

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  Xaa = F, W or Y

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  Xaa = N or S

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  Xaa = L or R

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  Xaa = A or E

<220>
<221>  VARIANT
<222>  (56)..(56)
<223>  Xaa = S or T

<220>
<221>  VARIANT
<222>  (58)..(58)
<223>  Xaa = I or V

<220>
<221>  VARIANT
<222>  (93)..(93)
<223>  Xaa = A, S or Y

<400>  121

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Xaa Xaa Xaa Xaa Gly Xaa Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Xaa Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  122
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  Xaa = E or Q

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  Xaa = F, H or Y

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  Xaa = I or K

<220>
<221>  VARIANT
<222>  (38)..(38)
<223>  Xaa = A or D

<220>
<221>  VARIANT
<222>  (57)..(57)
<223>  Xaa = N or S

<220>
<221>  VARIANT
<222>  (58)..(58)
<223>  Xaa = L or R

<220>
<221>  VARIANT
<222>  (59)..(59)
<223>  Xaa = A or E

<220>
<221>  VARIANT
<222>  (60)..(60)
<223>  Xaa = S or T

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  Xaa = I or V

<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  Xaa = A, H, S or Y

<400>  122

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Xaa Ser Val Asp Phe Xaa 
            20                  25                  30          


Gly Xaa Ser Phe Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Xaa Xaa Xaa Xaa Gly Xaa Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Xaa Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  123
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Xaa = Q or R

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  Xaa = D, S or T

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Xaa = K, S or T

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  Xaa = A or N

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  Xaa = S or T

<220>
<221>  VARIANT
<222>  (90)..(90)
<223>  Xaa = H or Q

<220>
<221>  VARIANT
<222>  (92)..(92)
<223>  Xaa = G, I, S, T or V

<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  Xaa = G, L, Q, R or V

<400>  123

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Xaa Ala Ser Gln Xaa Ile Pro Xaa Phe 
            20                  25                  30          


Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Xaa Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Xaa Tyr Xaa Ser Trp Pro Arg 
                85                  90                  95      


Xaa Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  124
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (29)..(29)
<223>  Xaa = I or V

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Xaa = P or S

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  Xaa = W or Y

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  Xaa = L or R

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  Xaa = A or E

<220>
<221>  VARIANT
<222>  (58)..(58)
<223>  Xaa = I or V

<220>
<221>  VARIANT
<222>  (93)..(93)
<223>  Xaa = A or S

<400>  124

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Xaa Ser Xaa Xaa 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Xaa Xaa Thr Gly Xaa Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Xaa Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  125
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  Xaa = S or T

<220>
<221>  VARIANT
<222>  (92)..(92)
<223>  Xaa = I or T

<400>  125

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Xaa Ile Pro Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Xaa Ser Trp Pro Arg 
                85                  90                  95      


Gln Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  126
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Ser Gly Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Gly Tyr Gly Tyr Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  127
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ile Ile Tyr Pro Ser Gly Gly Gly Thr Asn Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Gly Leu Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  128
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  128

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Pro Thr Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Val Ser Trp Pro Arg 
                85                  90                  95      


Gly Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  129
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  129

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Tyr Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  130
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  130

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Ser Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  131
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  131

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  132
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  132

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Phe Phe 
            20                  25                  30          


Gly Lys Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Ser Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  133
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  133

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Ser Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  134
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  134

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  135
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  135

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Phe Phe 
            20                  25                  30          


Gly Lys Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  136
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  136

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Phe His 
            20                  25                  30          


Gly Ile Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  137
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  137

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Pro Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  138
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  138

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Gly Ser Ile 
            20                  25                  30          


Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Trp Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  139
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  139

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Ala Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  140
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  140

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Tyr Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  141
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  141

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Ala Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  142
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  142

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  143
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  143

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Phe His 
            20                  25                  30          


Gly Lys Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  144
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  144

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Ser Pro Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  145
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  145

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Pro Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  146
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  146

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe His 
            20                  25                  30          


Gly Lys Ser Phe Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Ser Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  147
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  147

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Ser Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  148
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  148

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Ser Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  149
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  149

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Lys Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  150
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  150

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe His 
            20                  25                  30          


Gly Ile Ser Phe Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  151
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  151

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  152
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  152

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe His 
            20                  25                  30          


Gly Ile Ser Phe Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp 
                85                  90                  95      


Ser Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  153
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  153

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Pro Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Ser Ser Trp Pro Arg 
                85                  90                  95      


Gly Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  154
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  154

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Pro Lys Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Val Ser Trp Pro Arg 
                85                  90                  95      


Gln Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  155
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  155

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Pro Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Thr Ser Trp Pro Arg 
                85                  90                  95      


Gln Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  156
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  156

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Pro Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Trp Pro Arg 
                85                  90                  95      


Leu Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  157
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  157

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Pro Thr Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Val Ser Trp Pro Arg 
                85                  90                  95      


Leu Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  158
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  158

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Pro Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Ile Ser Trp Pro Arg 
                85                  90                  95      


Gln Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  159
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  159

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Pro Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Ile Ser Trp Pro Arg 
                85                  90                  95      


Val Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  160
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  160

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Pro Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Gly Ser Trp Pro Arg 
                85                  90                  95      


Arg Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  161
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  161

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  162
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  162

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Pro Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  163
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  163

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  164
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  164

Tyr Thr Phe Ser Asn Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  165
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  165

Ile Gly Trp Ile Tyr Pro Ser Gly Gly Gly Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  166
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  166

Ala Arg Glu Gly Gly Gly Tyr Gly Tyr Ala Leu Asp Tyr 
1               5                   10              


<210>  167
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  167

Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile 
1               5                   10          


<210>  168
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  168

Ile Gly Ile Ile Tyr Pro Ser Gly Gly Gly Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  169
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  169

Ala Arg Gly Gly Gly Leu Gly Phe Asp Tyr 
1               5                   10  


<210>  170
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  171
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  171

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  172
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa = F or Y

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = S or T

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = G, N or S

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = A, G or W

<400>  172

Xaa Thr Phe Xaa Xaa Tyr Xaa Ile His Trp Val 
1               5                   10      


<210>  173
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = S or T

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = H or Y

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = H or Y

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa = A, D, G, N, S or T

<400>  173

Tyr Ser Ile Xaa Ser Gly Xaa Xaa Trp Xaa Trp Ile 
1               5                   10          


<210>  174
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = G or S

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = A or G

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa = A, G, S or T

<400>  174

Phe Ser Leu Ser Thr Xaa Gly Val Xaa Val Xaa Trp Ile 
1               5                   10              


<210>  175
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = A, D or Y

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = D or G

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa = R, S or Y

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa = P or T

<400>  175

Leu Ala Leu Ile Asp Trp Xaa Xaa Asp Lys Xaa Tyr Ser Xaa Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  176
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = D or E

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = N or S

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa = N or S

<400>  176

Ile Gly Xaa Ile Tyr His Ser Gly Xaa Thr Tyr Tyr Xaa Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  177
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = A, G, S, V or Y

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = A, D, S or Y

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = D, G or S

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa = S or T

<400>  177

Val Ser Xaa Ile Ser Gly Xaa Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  178
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = E or G

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = E or S

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = D or T

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = A, T or V

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = A, I, L, T or V

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa = A, D or G

<400>  178

Ala Arg Xaa Gly Xaa Xaa Xaa Val Xaa Gly Asp Trp Phe Xaa Tyr 
1               5                   10                  15  


<210>  179
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa = Q or R

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = D, G or S

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = I or V

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = G, R, S or T

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = P, R, S or T

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = A, D, F, S, V or Y

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa = L or V

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa = A, G or N

<400>  179

Xaa Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  180
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa = A or D

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = N, S or T

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = L or R

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = A, E or Q

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = S or T

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = I or V

<400>  180

Xaa Ala Ser Xaa Xaa Xaa Xaa Gly Xaa 
1               5                   


<210>  181
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = A, G, S or Y

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Q, S or Y

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = I, L, T or Y

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = I, S, V or W

<400>  181

Tyr Cys Gln Gln Xaa Tyr Xaa Xaa Xaa Thr 
1               5                   10  


<210>  182
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = E or Q

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = P, S or Y

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = D, L, S, T or Y

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = D, E, H, S or T

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = D, L, T or W

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa = L, P, R or V

<400>  182

Tyr Cys Xaa Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   10      



