                         SEQUENCE LISTING

<110>  BRISTOL-MYERS SQUIBB COMPANY
 
<120>  ANTIBODIES AGAINST MICA AND/OR MICB AND USES THEREOF

<130>  3338.101PC02/ELE/C-K/BMD

<150>  US 62/667,170
<151>  2018-05-04

<150>  US 62/647,556
<151>  2018-03-23

<160>  133   
<170>  PatentIn version 3.5

<210>  1
<211>  345
<212>  DNA
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VH1

<400>  1
caggtgcaac tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt aactatgcca tgcactgggt ccgccaggct      120

ccaggcgagg ggctggaatg ggtggcactt atatggtatg atggaagtaa taaattctat      180

ggagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag cgccgaggac acggctgtgt attactgtgc gagagaggga      300

agtgggcact actggggcca gggaaccctg gtcaccgtct cctca                      345


<210>  2
<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VH1

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Phe Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Gly His Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  3
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VK1

<400>  3
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcatcagc agtgctttag cctggtatca gcagaaacca      120

gggaaagttc ctaagtccct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgatcac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210>  4
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VK1

<400>  4

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VH1_CDR1

<400>  5

Asn Tyr Ala Met His 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VH1_CDR2

<400>  6

Leu Ile Trp Tyr Asp Gly Ser Asn Lys Phe Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VH1_CDR3

<400>  7

Glu Gly Ser Gly His Tyr 
1               5       


<210>  8
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VK1_CDR1

<400>  8

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VK1_CDR2

<400>  9

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 VK1_CDR3

<400>  10

Gln Gln Phe Asn Ser Tyr Pro Ile Thr 
1               5                   


<210>  11
<211>  408
<212>  DNA
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VH1

<400>  11
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcagctgg tggagtctgg gggagacgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcagcgt ctggattcac cttcagtaac tataacatac actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata aggtatgatg gaattaataa atactatgca      240

gactccgtga agggccgatt catcatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag cgggccccct      360

gatgctttta atatctgggg ccaagggaca atggtcaccg tctcttca                   408


<210>  12
<211>  136
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VH1

<400>  12

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Asn Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Arg Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Gly Pro Pro Asp Ala Phe Asn Ile Trp Gly Gln 
        115                 120                 125             


Gly Thr Met Val Thr Val Ser Ser 
    130                 135     


<210>  13
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VK1

<400>  13
atgagggtcc ccgctcagct cctggggctt ctgctgctct ggctcccagg tgccagatgt       60

gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcaagtca gggcatcagc agtgctttag cctggtatca gcagaaacca      180

gggaaagttc ctaagtccct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      240

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgatcac cttcggccaa      360

gggacacgac tggagattaa a                                                381


<210>  14
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VK1

<400>  14

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro 
    50                  55                  60                  


Lys Ser Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn 
            100                 105                 110         


Ser Tyr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
        115                 120                 125         


<210>  15
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VH1_CDR1

<400>  15

Asn Tyr Asn Ile His 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VH1_CDR2

<400>  16

Val Ile Arg Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VH1_CDR3

<400>  17

Gly Pro Pro Asp Ala Phe Asn Ile 
1               5               


<210>  18
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VK1_CDR1

<400>  18

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VK1_CDR2

<400>  19

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VK1_CDR3

<400>  20

Gln Gln Phe Asn Ser Tyr Pro Ile Thr 
1               5                   


<210>  21
<211>  414
<212>  DNA
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VH1

<400>  21
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt ctgtgccgag       60

gtgcagctgg tgcagtctgg agcagaggtg aaaaagcccg gggagtctct gaagatctcc      120

tgtaagggtt ctggatacag ttttaccaac tactggatcg gctgggtgcg ccagatgccc      180

gggaaaggcc tggagtggtt ggggatcatc catcctggtg actcttatac cagatacagc      240

ccgtccttcc aaggccaggt caccatctca gccgacaagt ccatcagcac cgcctacctg      300

cagtggagca gcctgaaggc ctcggacacc gccatatatt actgtgcgag agagggtata      360

gcagcaactc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            414


<210>  22
<211>  138
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VH1

<400>  22

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Cys Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Ile Ile His Pro Gly Asp Ser Tyr Thr Arg Tyr Ser 
65                  70                  75                  80  


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Ile Ala Ala Thr Pro Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135             


<210>  23
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VK1

<400>  23
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agctacttag cctggttcca acagaaacct      180

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      240

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      300

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccgac gttcggccaa      360

gggaccaagg tggaaatcaa a                                                381


<210>  24
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VK1

<400>  24

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125         


<210>  25
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VH1_CDR1

<400>  25

Asn Tyr Trp Ile Gly 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VH1_CDR2

<400>  26

Ile Ile His Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VH1_CDR3

<400>  27

Glu Gly Ile Ala Ala Thr Pro Phe Asp Tyr 
1               5                   10  


<210>  28
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VK1_CDR1

<400>  28

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VK1_CDR2

<400>  29

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 VK1_CDR3

<400>  30

Gln Gln Arg Ser Asn Trp Pro Pro Thr 
1               5                   


<210>  31
<211>  414
<212>  DNA
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VH1

<400>  31
atggagttgg ggctgtgctg gattttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcaactgg tggaatctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac cttcagtacc tatagcatga actgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ttcatacatt agttatcgta gtcgtaccat atactacgca      240

gactctgtga agggccgatt caccatctcc agagacaatg ccaggaactc actgtatctg      300

caaatgaaca gcctgagaga cgaggacacg gctgtgtatt actgtgcgag atggggctat      360

ggttcggggg gctttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            414


<210>  32
<211>  138
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VH1

<400>  32

Met Glu Leu Gly Leu Cys Trp Ile Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Tyr Ile Ser Tyr Arg Ser Arg Thr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly Tyr Gly Ser Gly Gly Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135             


<210>  33
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VK1

<400>  33
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcattcac tttcggccct      360

gggaccaaag tggatatcaa a                                                381


<210>  34
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VK1

<400>  34

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
        115                 120                 125         


<210>  35
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VH1_CDR1

<400>  35

Thr Tyr Ser Met Asn 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VH1_CDR2

<400>  36

Tyr Ile Ser Tyr Arg Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VH1_CDR3

<400>  37

Trp Gly Tyr Gly Ser Gly Gly Phe Asp Tyr 
1               5                   10  


<210>  38
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VK1_CDR1

<400>  38

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  39
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VK1_CDR2

<400>  39

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  40
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 VK1_CDR3

<400>  40

Gln Gln Tyr Gly Ser Ser Phe Thr 
1               5               


<210>  41
<211>  420
<212>  DNA
<213>  artificial sequence

<220>
<223>  71C2 VH1

<400>  41
atggagttgg gactgagctg gattttcctt ttggctattt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggagtctgg gggaggcttg gtacagcctg gcaggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttaataat tatgccatgc actgggtccg gcaagctcca      180

gggaagggcc tggagtgggt ctcaggtatt acttggaata gtgatagcat aggctatgcg      240

gactctgtga agggccgatt caccatctcc agagacaacg ccaagaactc cctgtatctg      300

caaatgaaca gtctgagagc tgaggacacg gccttgtatt actgtgcaaa agattccgta      360

ttactatggt tcgggggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      420


<210>  42
<211>  140
<212>  PRT
<213>  artificial sequence

<220>
<223>  71C2 VH1

<400>  42

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Asn Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Thr Trp Asn Ser Asp Ser Ile Gly Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Ser Val Leu Leu Trp Phe Gly Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140 


<210>  43
<211>  387
<212>  DNA
<213>  artificial sequence

<220>
<223>  71C2 VK1

<400>  43
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcc gtacactttt      360

ggccagggga ccaagctgga gatcaaa                                          387


<210>  44
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  71C2 VK1

<400>  44

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys 
    


<210>  45
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  71C2 VH1_CDR1

<400>  45

Asn Tyr Ala Met His 
1               5   


<210>  46
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  71C2 VH1_CDR2

<400>  46

Gly Ile Thr Trp Asn Ser Asp Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  71C2 VH1_CDR3

<400>  47

Asp Ser Val Leu Leu Trp Phe Gly Gly Met Asp Val 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  71C2 VK1_CDR1

<400>  48

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  49
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  71C2 VK1_CDR2

<400>  49

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  50
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  71C2 VK1_CDR3

<400>  50

Gln Gln Tyr Gly Ser Ser Pro Pro Tyr Thr 
1               5                   10  


<210>  51
<211>  332
<212>  PRT
<213>  artificial sequence

<220>
<223>  human MICA aa sequence

<400>  51

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Glu Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Ile Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Arg Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Gly Cys Cys 
305                 310                 315                 320 


Tyr Phe Cys Tyr Tyr Tyr Phe Leu Cys Pro Leu Leu 
                325                 330         


<210>  52
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.36 NF G236A Epitope Region 1

<400>  52

Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met 
1               5                   10                  


<210>  53
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.36 NF G236A Epitope Region 2

<400>  53

Tyr Pro Arg Asn Ile Ile Leu Thr 
1               5               


<210>  54
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.36 NF G236A Epitope Region 3.1

<400>  54

Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln 
1               5                   10      


<210>  55
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.36 NF G236A Epitope Region 3.2

<400>  55

Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp 
1               5                   10                  15  


<210>  56
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.2 Epitope Region 1

<400>  56

Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu Ala 
1               5                   10                  15      


Ser Glu Gly Asn 
            20  


<210>  57
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.2 Epitope Region 2

<400>  57

Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln 
1               5                   10                  15  


<210>  58
<211>  444
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 Heavy Chain AA

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Phe Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Gly His Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  59
<211>  1332
<212>  DNA
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 Heavy Chain NT

<400>  59
caggtgcaac tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt aactatgcca tgcactgggt ccgccaggct      120

ccaggcgagg ggctggaatg ggtggcactt atatggtatg atggaagtaa taaattctat      180

ggagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag cgccgaggac acggctgtgt attactgtgc gagagaggga      300

agtgggcact actggggcca gggaaccctg gtcaccgtct cctcagctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaactcctgg cgggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctatagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtccccgg gt                                                         1332


<210>  60
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 Light Chain AA

<400>  60

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  61
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  19G6-MICA.36 Light Chain NT

<400>  61
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcatcagc agtgctttag cctggtatca gcagaaacca      120

gggaaagttc ctaagtccct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgatcac cttcggccaa      300

gggacacgac tggagattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  62
<211>  446
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 Heavy Chain AA

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Arg Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Pro Pro Asp Ala Phe Asn Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  63
<211>  1338
<212>  DNA
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 Heavy Chain NT

<400>  63
caggtgcagc tggtggagtc tgggggagac gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt aactataaca tacactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt ataaggtatg atggaattaa taaatactat      180

gcagactccg tgaagggccg attcatcatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagcgggccc      300

cctgatgctt ttaatatctg gggccaaggg acaatggtca ccgtctcttc agctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ccccgggt                                                   1338


<210>  64
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 Light Chain AA

<400>  64

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  65
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 Light Chain NT

<400>  65
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcatcagc agtgctttag cctggtatca gcagaaacca      120

gggaaagttc ctaagtccct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgatcac cttcggccaa      300

gggacacgac tggagattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  66
<211>  448
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 Heavy Chain AA

<400>  66

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ile Ile His Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ile Ala Ala Thr Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  67
<211>  1344
<212>  DNA
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 Heavy Chain NT

<400>  67
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc aactactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gttggggatc atccatcctg gtgactctta taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatat attactgtgc gagagagggt      300

atagcagcaa ctccctttga ctactggggc cagggaaccc tggtcaccgt ctcctcagct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtcccc gggt                                            1344


<210>  68
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 Light Chain AA

<400>  68

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  69
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  24G11-MICA.54 Light Chain NT

<400>  69
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggttcca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccgac gttcggccaa      300

gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  70
<211>  448
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 Heavy Chain AA

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Tyr Arg Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Gly Ser Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  71
<211>  1344
<212>  DNA
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 Heavy Chain NT

<400>  71
gaggtgcaac tggtggaatc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagttatc gtagtcgtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaggaa ctcactgtat      240

ctgcaaatga acagcctgag agacgaggac acggctgtgt attactgtgc gagatggggc      300

tatggttcgg ggggctttga ctactggggc cagggaaccc tggtcaccgt ctcctcagct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtcccc gggt                                            1344


<210>  72
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 Light Chain AA

<400>  72

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  73
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  3F5-MICA.2 Light Chain NT

<400>  73
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcattcac tttcggccct      300

gggaccaaag tggatatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  74

<400>  74
000

<210>  75

<400>  75
000

<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR VH

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Glu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Met Val Arg Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120             


<210>  79
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR VL

<400>  79

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  80
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR VH

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Ala Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Leu Asp Tyr Tyr Tyr Tyr Tyr Val Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  81
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR VL

<400>  81

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  82
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR VH

<400>  82

Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Val Ile Trp Tyr Ala Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Arg Ile Ala Val Ala Phe Tyr Tyr Ser Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR VL

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  84
<211>  449
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR Heavy Chain

<400>  84

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Glu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Met Val Arg Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
    210                 215                 220                 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  85
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR Light Chain

<400>  85

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  86
<211>  453
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR Heavy Chain

<400>  86

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Glu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Met Val Arg Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210>  87
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  GITR Light Chain

<400>  87

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  88
<211>  287
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human MICA Isoform 2 (MICA2)

<400>  88

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Val Pro Pro Met 
            100                 105                 110         


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
        115                 120                 125             


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
    130                 135                 140                 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
145                 150                 155                 160 


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
                165                 170                 175     


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
            180                 185                 190         


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
        195                 200                 205             


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
    210                 215                 220                 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
225                 230                 235                 240 


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
                245                 250                 255     


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
            260                 265                 270         


Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala 
        275                 280                 285         


<210>  89
<211>  284
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA EC Domain

<400>  89

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser Gly Lys Val Leu Val Leu Gln Ser His Trp 
        275                 280                 


<210>  90
<211>  274
<212>  PRT
<213>  artificial sequence

<220>
<223>  Cynomolgus monkey MICA (partial) UniProt-Q2MGE0

<400>  90

Glu Leu His Ser Leu Arg Tyr Asn Val Thr Val Leu Ser Arg Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln Leu 
            20                  25                  30          


Phe Leu Leu Tyr Asp Arg Gln Lys Cys Arg Ala Arg Pro Gln Gly Glu 
        35                  40                  45              


Trp Ser Glu Asp Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr Gly 
    50                  55                  60                  


Asp Leu Thr Glu Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Gly Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Lys Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Gly Gly Leu Arg His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Trp Thr 
        115                 120                 125             


Glu Leu Gln Ser Ser Arg Ala Gln Thr Leu Ala Leu Asn Ile Arg Asn 
    130                 135                 140                 


Phe Trp Lys Glu Asp Thr Met Lys Thr Lys Thr His Tyr Arg Ala Val 
145                 150                 155                 160 


Gln Ala Asp Cys Leu Lys Lys Leu Gln Gln Tyr Leu Glu Ser Gly Val 
                165                 170                 175     


Ala Val Arg Arg Thr Ala Pro Pro Met Val Asn Val Thr His Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Arg Asn Ile Ala Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Asn 
    210                 215                 220                 


His Asn Ala Gln Gln Trp Gly Gly Ile Leu Pro Asp Gln Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Ala Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser 
        


<210>  91
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Wild-type human IgG

<400>  91

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  92
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Allotypic variant of human IgG

<400>  92

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  93
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1.1f - effectorless human IgG1 constant domain

<400>  93

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  94
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1.3f - effectorless human IgG1 constant domain

<400>  94

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  95
<211>  327
<212>  PRT
<213>  artificial sequence

<220>
<223>  human IgG4

<400>  95

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  96
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human IgG1 kappa light chain

<400>  96

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  97
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain constant region C-terminus

<400>  97

Leu Ser Pro Gly Lys 
1               5   


<210>  98
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain constant region C-terminus

<400>  98

Leu Ser Pro Gly 
1               


<210>  99
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain constant region C-terminus

<400>  99

Leu Ser Pro 
1           


<210>  100
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  100

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  101
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  101

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  102
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  102

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  103
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  103

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  104
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  104

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Trp Leu 
1               5                   10                  15      


Pro Gly Ala Arg Cys 
            20      


<210>  105
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  105

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  106
<211>  51
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  106

Ala Thr Gly Ala Gly Gly Gly Cys Thr Thr Gly Gly Ala Thr Cys Thr 
1               5                   10                  15      


Thr Cys Thr Thr Thr Cys Thr Gly Cys Thr Cys Thr Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Cys Gly Gly Gly Ala Gly Ala Gly Cys Gly Cys Thr Cys 
        35                  40                  45              


Gly Cys Ala 
    50      


<210>  107
<211>  51
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  107

Ala Thr Gly Ala Gly Gly Gly Cys Thr Thr Gly Gly Ala Thr Cys Thr 
1               5                   10                  15      


Thr Cys Thr Thr Thr Cys Thr Gly Cys Thr Cys Thr Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Cys Gly Gly Gly Cys Gly Cys Gly Cys Cys Thr Thr Gly 
        35                  40                  45              


Gly Cys Cys 
    50      


<210>  108
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  108

Pro Val Gly Val Val 
1               5   


<210>  109
<211>  383
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA1 (MICA Variant)

<400>  109

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  110
<211>  383
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA*002

<400>  110

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Gly Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Glu Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Thr 
    370                 375                 380             


<210>  111
<211>  385
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA*004

<400>  111

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Val Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Glu Ser Ser Val Val Leu Arg Arg Arg Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Ser Thr Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ile Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys 
                325                 330                 335     


Thr Ser Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp 
            340                 345                 350         


Gln His Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly 
        355                 360                 365             


Phe Gln Pro Leu Met Ser Ala Leu Gly Ser Thr Gly Ser Thr Glu Gly 
    370                 375                 380                 


Ala 
385 


<210>  112
<211>  331
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA*008

<400>  112

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Glu Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Ile Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Arg Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys 
                325                 330     


<210>  113
<211>  383
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA*009

<400>  113

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Glu Ser Ser Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Ala Leu Gly Ser Thr Gly Ser Thr Glu Gly Thr 
    370                 375                 380             


<210>  114
<211>  384
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA*010

<400>  114

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Pro Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Glu Glu Trp Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Glu Ser Ser Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Ile Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Arg Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ile Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr 
                325                 330                 335     


Ser Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln 
            340                 345                 350         


His Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe 
        355                 360                 365             


Gln Pro Leu Met Ser Ala Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380                 


<210>  115
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.20 VH

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Tyr Arg Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Gly Ser Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  116
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.20 VL

<400>  116

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  117
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.21 VH

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Tyr Arg Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Gly Ser Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  118
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.21 VL

<400>  118

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  119
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.22 VH

<400>  119

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Tyr Arg Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Gly Ser Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  120
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.22 VL

<400>  120

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  121
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.38 VH

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Tyr Arg Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Gly Ser Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  122
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  MICA.38 VL

<400>  122

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Ser 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  123

<400>  123
000

<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127
<211>  387
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VK2

<400>  127

Ala Thr Gly Gly Ala Cys Ala Thr Gly Ala Gly Gly Gly Thr Cys Cys 
1               5                   10                  15      


Cys Cys Gly Cys Thr Cys Ala Gly Cys Thr Cys Cys Thr Gly Gly Gly 
            20                  25                  30          


Gly Cys Thr Thr Cys Thr Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly 
        35                  40                  45              


Cys Thr Cys Cys Cys Ala Gly Gly Thr Gly Cys Cys Ala Gly Ala Thr 
    50                  55                  60                  


Gly Thr Gly Cys Cys Ala Thr Cys Cys Ala Gly Thr Thr Gly Ala Cys 
65                  70                  75                  80  


Cys Cys Ala Gly Thr Cys Thr Cys Cys Ala Thr Cys Cys Thr Cys Cys 
                85                  90                  95      


Cys Thr Gly Thr Cys Thr Gly Cys Ala Thr Cys Thr Gly Thr Ala Gly 
            100                 105                 110         


Gly Ala Gly Ala Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr 
        115                 120                 125             


Cys Ala Cys Thr Thr Gly Cys Cys Gly Gly Gly Cys Ala Ala Gly Thr 
    130                 135                 140                 


Cys Ala Gly Gly Gly Cys Ala Thr Thr Ala Gly Cys Ala Gly Thr Gly 
145                 150                 155                 160 


Cys Thr Thr Thr Ala Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala 
                165                 170                 175     


Gly Cys Ala Gly Ala Ala Ala Cys Cys Ala Gly Gly Gly Ala Ala Ala 
            180                 185                 190         


Gly Cys Thr Cys Cys Thr Ala Ala Gly Cys Thr Cys Cys Thr Gly Ala 
        195                 200                 205             


Thr Cys Thr Ala Thr Gly Ala Thr Gly Cys Cys Thr Cys Cys Ala Gly 
    210                 215                 220                 


Thr Thr Thr Gly Gly Ala Ala Ala Gly Thr Gly Gly Gly Gly Thr Cys 
225                 230                 235                 240 


Cys Cys Ala Thr Cys Ala Ala Gly Gly Thr Thr Cys Ala Gly Cys Gly 
                245                 250                 255     


Gly Cys Ala Gly Thr Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Cys 
            260                 265                 270         


Ala Gly Ala Thr Thr Thr Cys Ala Cys Thr Cys Thr Cys Ala Cys Cys 
        275                 280                 285             


Ala Thr Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Cys Ala Gly Cys 
    290                 295                 300                 


Cys Thr Gly Ala Ala Gly Ala Thr Thr Thr Thr Gly Cys Ala Ala Cys 
305                 310                 315                 320 


Thr Thr Ala Thr Thr Ala Cys Thr Gly Thr Cys Ala Ala Cys Ala Gly 
                325                 330                 335     


Thr Thr Thr Ala Ala Thr Ala Gly Thr Thr Ala Cys Cys Cys Ala Thr 
            340                 345                 350         


Thr Cys Ala Cys Thr Thr Thr Cys Gly Gly Cys Cys Cys Thr Gly Gly 
        355                 360                 365             


Gly Ala Cys Cys Ala Ala Ala Gly Thr Gly Gly Ala Thr Ala Thr Cys 
    370                 375                 380                 


Ala Ala Ala 
385         


<210>  128
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  16A5-MICA.52 VK2

<400>  128

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Phe Asn Ser Tyr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys 
    


<210>  129

<400>  129
000

<210>  130
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19G6-MICA.36 Heavy Chain AA (236G)

<400>  130

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Phe Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Gly His Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  131
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  19G6-MICA.36 Heavy Chain NT (236G)

<400>  131
caggtgcaac tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt aactatgcca tgcactgggt ccgccaggct      120

ccaggcgagg ggctggaatg ggtggcactt atatggtatg atggaagtaa taaattctat      180

ggagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag cgccgaggac acggctgtgt attactgtgc gagagaggga      300

agtgggcact actggggcca gggaaccctg gtcaccgtct cctcagctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctatagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtccccgg gt                                                         1332


<210>  132
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Met Val Leu Ser Gln Asp Glu Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Ala Lys 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
                85                  90                  95      


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg 
        115                 120                 125             


Gly Ser Arg His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Gly Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe 
305                 310                 315                 320 


Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  133
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Met Val Leu Ser Gln Asp Glu Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Ala Lys 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
                85                  90                  95      


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Val Pro Gln Ser 
            100                 105                 110         


Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu 
        115                 120                 125             


Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys 
    130                 135                 140                 


Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg 
145                 150                 155                 160 


Thr Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly 
                165                 170                 175     


Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile 
            180                 185                 190         


Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln 
        195                 200                 205             


Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp 
    210                 215                 220                 


Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr 
225                 230                 235                 240 


Met Glu His Ser Gly Asn His Gly Thr His Pro Val Pro Ser Gly Lys 
                245                 250                 255     


Val Leu Val Leu Gln Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala 
            260                 265                 270         


Ala Met Pro Cys Phe Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys 
        275                 280                 285             


Lys Lys Lys Thr Ser Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln 
    290                 295                 300                 


Val Leu Asp Gln His Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala 
305                 310                 315                 320 


Gln Leu Gly Phe Gln Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser 
                325                 330                 335     


Thr Glu Gly Ala 
            340 


