                         SEQUENCE LISTING

<110>  Casebia Therapeutics Limited Liability Partnership
       Cohnen, Andre
       Schmidt, Moritz
       Coco, Wayne
       Gamalinda, Michael Biag
       Gupta, Ashish
       Pitzler, Christian
       Richter, Florian
       Tebbe, Jan
       Cheng, Christopher
       Takeuchi, Ryo
       Reiss, Caroline W
 
<120>  Novel RNA-Programmable Endonuclease Systems and Uses Thereof

<130>  052984-523001WO

<140>  PCT/US2019/023044
<141>  2019-03-19

<150>  EP 18162681.3
<151>  2013-03-19

<150>  EP 18162683.9
<151>  2018-03-19

<150>  EP 18172625.8
<151>  2018-05-16

<150>  EP 18174707.2
<151>  2018-05-16

<150>  EP 18181680.2
<151>  2018-07-04

<150>  US 62/745,238
<151>  2018-10-12

<150>  US 62/745,239
<151>  2018-10-12

<150>  US 62/745,240
<151>  2018-10-12

<150>  US 62/745,246
<151>  2018-10-12

<160>  538   

<170>  PatentIn version 3.5

<210>  1
<211>  1057
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of Gib11

<400>  1

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Leu Leu Leu Thr Glu Tyr Asp Leu Ile Asn Lys Glu 
65                  70                  75                  80  


Gln Ile Pro Thr Ser Asn Asn Pro Tyr Gln Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ile Leu Ser Lys Asp Glu Leu Ala Ile Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu 
        115                 120                 125             


Glu Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn 
    130                 135                 140                 


Ala Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr 
                165                 170                 175     


Lys Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln 
            180                 185                 190         


Tyr Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu 
        195                 200                 205             


Val Glu Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro 
    210                 215                 220                 


Phe Gly Trp Asn Gly Asp Leu Lys Lys Trp Tyr Glu Met Leu Met Gly 
225                 230                 235                 240 


His Cys Thr Tyr Phe Pro Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr 
                245                 250                 255     


Ser Ala Asp Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile 
            260                 265                 270         


Gln Arg Asp Asn Ser Glu Lys Leu Glu Tyr His Glu Lys Tyr His Ile 
        275                 280                 285             


Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile 
    290                 295                 300                 


Ala Lys Glu Ile Gly Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile 
305                 310                 315                 320 


Thr Lys Ser Gly Thr Pro Glu Phe Thr Ser Phe Lys Leu Phe His Asp 
                325                 330                 335     


Leu Lys Lys Val Val Lys Asp His Ala Ile Leu Asp Asp Ile Asp Leu 
            340                 345                 350         


Leu Asn Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser 
        355                 360                 365             


Ile Val Ala Glu Leu Gly Gln Leu Glu Tyr Leu Met Ser Glu Ala Asp 
    370                 375                 380                 


Lys Gln Ser Ile Ser Glu Leu Thr Gly Tyr Thr Gly Thr His Ser Leu 
385                 390                 395                 400 


Ser Leu Lys Cys Met Asn Met Ile Ile Asp Glu Leu Trp His Ser Ser 
                405                 410                 415     


Met Asn Gln Met Glu Val Phe Thr Tyr Leu Asn Met Arg Pro Lys Lys 
            420                 425                 430         


Tyr Glu Leu Lys Gly Tyr Gln Arg Ile Pro Thr Asp Met Ile Asp Asp 
        435                 440                 445             


Ala Ile Leu Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn 
    450                 455                 460                 


Val Ile Asn Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile 
465                 470                 475                 480 


Ile Glu Leu Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile 
                485                 490                 495     


Asn Asn Leu Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu 
            500                 505                 510         


Ile Ile Gly Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys 
        515                 520                 525             


Ile Arg Leu His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu 
    530                 535                 540                 


Ser Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val 
545                 550                 555                 560 


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn 
                565                 570                 575     


Lys Val Leu Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr 
            580                 585                 590         


Pro Tyr Gln Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln 
        595                 600                 605             


Phe Lys Gln His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser 
    610                 615                 620                 


Lys Lys Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe 
625                 630                 635                 640 


Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
                645                 650                 655     


Ala Thr Arg Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn 
            660                 665                 670         


Asn Met Asn Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr 
        675                 680                 685             


Leu Arg Lys Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys 
    690                 695                 700                 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe 
705                 710                 715                 720 


Lys Glu Asn Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro 
                725                 730                 735     


Glu Ile Glu Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn 
            740                 745                 750         


Tyr Ser Glu Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp 
        755                 760                 765             


Phe Arg Asn Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser 
785                 790                 795                 800 


Thr Tyr Ile Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr 
                805                 810                 815     


Thr Leu Lys Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr 
            820                 825                 830         


Gln His Asp Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln 
        835                 840                 845             


Tyr Ala Asn Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly 
    850                 855                 860                 


Glu Tyr Leu Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys 
865                 870                 875                 880 


Ser Leu Lys Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr 
                885                 890                 895     


His Gln Phe Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            900                 905                 910         


Pro Tyr Arg Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile 
        915                 920                 925             


Thr Ile Ser Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile 
    930                 935                 940                 


Pro Glu Gln Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys 
945                 950                 955                 960 


Asn Ala Lys Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
                965                 970                 975     


Asp Gly Glu Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn 
            980                 985                 990         


Met Ile Glu Leu Asp Leu Pro Asp  Ile Arg Tyr Lys Glu  Tyr Cys Glu 
        995                 1000                 1005             


Leu Asn  Asn Ile Lys Gly Glu  Pro Arg Ile Lys Lys  Thr Ile Gly 
    1010                 1015                 1020             


Lys Lys  Val Asn Ser Ile Glu  Lys Leu Thr Thr Asp  Val Leu Gly 
    1025                 1030                 1035             


Asn Val  Phe Thr Asn Thr Gln  Tyr Thr Lys Pro Gln  Leu Leu Phe 
    1040                 1045                 1050             


Lys Arg  Gly Asn 
    1055         


<210>  2
<211>  1057
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of Gib11Spa-1

<400>  2

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Leu Leu Leu Thr Glu Tyr Asp Leu Ile Asn Lys Glu 
65                  70                  75                  80  


Gln Ile Pro Thr Ser Asn Asn Pro Tyr Gln Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ile Leu Ser Lys Asp Glu Leu Ala Ile Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu 
        115                 120                 125             


Glu Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn 
    130                 135                 140                 


Ala Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr 
                165                 170                 175     


Lys Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln 
            180                 185                 190         


Tyr Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu 
        195                 200                 205             


Val Glu Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro 
    210                 215                 220                 


Phe Gly Trp Asn Gly Asp Leu Lys Lys Trp Tyr Glu Met Leu Met Gly 
225                 230                 235                 240 


His Cys Thr Tyr Phe Pro Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr 
                245                 250                 255     


Ser Ala Asp Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile 
            260                 265                 270         


Gln Arg Asp Asn Ser Glu Lys Leu Glu Tyr His Glu Lys Tyr His Ile 
        275                 280                 285             


Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile 
    290                 295                 300                 


Ala Lys Glu Ile Gly Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile 
305                 310                 315                 320 


Thr Lys Ser Gly Thr Pro Glu Phe Thr Ser Phe Lys Leu Phe His Asp 
                325                 330                 335     


Leu Lys Lys Val Val Lys Asp His Ala Ile Leu Asp Asp Ile Asp Leu 
            340                 345                 350         


Leu Asn Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser 
        355                 360                 365             


Ile Val Ala Glu Leu Gly Gln Leu Glu Tyr Leu Met Ser Glu Ala Asp 
    370                 375                 380                 


Lys Gln Ser Ile Ser Glu Leu Thr Gly Tyr Thr Gly Thr His Ser Leu 
385                 390                 395                 400 


Ser Leu Lys Cys Met Asn Met Ile Ile Asp Glu Leu Trp His Ser Ser 
                405                 410                 415     


Met Asn Gln Met Glu Val Phe Thr Tyr Leu Asn Met Arg Pro Lys Lys 
            420                 425                 430         


Tyr Glu Leu Lys Gly Tyr Gln Arg Ile Pro Thr Asp Met Ile Asp Asp 
        435                 440                 445             


Ala Ile Leu Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn 
    450                 455                 460                 


Val Ile Asn Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile 
465                 470                 475                 480 


Ile Glu Leu Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile 
                485                 490                 495     


Asn Asn Leu Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu 
            500                 505                 510         


Ile Ile Gly Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys 
        515                 520                 525             


Ile Arg Leu His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu 
    530                 535                 540                 


Ser Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val 
545                 550                 555                 560 


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn 
                565                 570                 575     


Lys Val Leu Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr 
            580                 585                 590         


Pro Tyr Gln Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln 
        595                 600                 605             


Phe Lys Gln His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser 
    610                 615                 620                 


Lys Lys Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe 
625                 630                 635                 640 


Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
                645                 650                 655     


Ala Thr Arg Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn 
            660                 665                 670         


Asn Met Asn Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr 
        675                 680                 685             


Leu Arg Lys Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys 
    690                 695                 700                 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe 
705                 710                 715                 720 


Lys Glu Asn Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro 
                725                 730                 735     


Glu Ile Glu Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn 
            740                 745                 750         


Tyr Ser Glu Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp 
        755                 760                 765             


Phe Arg Asn Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser 
785                 790                 795                 800 


Thr Tyr Ile Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr 
                805                 810                 815     


Thr Leu Lys Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr 
            820                 825                 830         


Gln His Asp Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln 
        835                 840                 845             


Tyr Ala Asn Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly 
    850                 855                 860                 


Glu Tyr Leu Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys 
865                 870                 875                 880 


Ser Leu Lys Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr 
                885                 890                 895     


His Gln Phe Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            900                 905                 910         


Asn Tyr Arg Phe Asp Val Tyr Leu Thr Glu Lys Gly Tyr Lys Phe Val 
        915                 920                 925             


Thr Ile Ala Tyr Leu Asn Val Phe Lys Lys Asp Asn Tyr Tyr Tyr Ile 
    930                 935                 940                 


Pro Lys Asp Lys Tyr Gln Glu Leu Lys Glu Lys Lys Lys Ile Lys Asp 
945                 950                 955                 960 


Thr Asp Gln Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
                965                 970                 975     


Asn Gly Asp Leu Tyr Lys Ile Ile Gly Val Asn Ser Asp Asp Arg Asn 
            980                 985                 990         


Ile Ile Glu Leu Asp Tyr Tyr Asp  Ile Lys Tyr Lys Asp  Tyr Cys Glu 
        995                 1000                 1005             


Ile Asn  Asn Ile Lys Gly Glu  Pro Arg Ile Lys Lys  Thr Ile Gly 
    1010                 1015                 1020             


Lys Lys  Thr Glu Ser Ile Glu  Lys Phe Thr Thr Asp  Val Leu Gly 
    1025                 1030                 1035             


Asn Leu  Tyr Leu His Ser Thr  Glu Lys Ala Pro Gln  Leu Ile Phe 
    1040                 1045                 1050             


Lys Arg  Gly Leu 
    1055         


<210>  3
<211>  1057
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of Gib11Spa-2

<400>  3

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Leu Leu Leu Thr Glu Tyr Asp Leu Ile Asn Lys Glu 
65                  70                  75                  80  


Gln Ile Pro Thr Ser Asn Asn Pro Tyr Gln Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ile Leu Ser Lys Asp Glu Leu Ala Ile Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu 
        115                 120                 125             


Glu Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn 
    130                 135                 140                 


Ala Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr 
                165                 170                 175     


Lys Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln 
            180                 185                 190         


Tyr Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu 
        195                 200                 205             


Val Glu Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro 
    210                 215                 220                 


Phe Gly Trp Asn Gly Asp Leu Lys Lys Trp Tyr Glu Met Leu Met Gly 
225                 230                 235                 240 


His Cys Thr Tyr Phe Pro Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr 
                245                 250                 255     


Ser Ala Asp Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile 
            260                 265                 270         


Gln Arg Asp Asn Ser Glu Lys Leu Glu Tyr His Glu Lys Tyr His Ile 
        275                 280                 285             


Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile 
    290                 295                 300                 


Ala Lys Glu Ile Gly Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile 
305                 310                 315                 320 


Thr Lys Ser Gly Thr Pro Glu Phe Thr Ser Phe Lys Leu Phe His Asp 
                325                 330                 335     


Leu Lys Lys Val Val Lys Asp His Ala Ile Leu Asp Asp Ile Asp Leu 
            340                 345                 350         


Leu Asn Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser 
        355                 360                 365             


Ile Val Ala Glu Leu Gly Gln Leu Glu Tyr Leu Met Ser Glu Ala Asp 
    370                 375                 380                 


Lys Gln Ser Ile Ser Glu Leu Thr Gly Tyr Thr Gly Thr His Ser Leu 
385                 390                 395                 400 


Ser Leu Lys Cys Met Asn Met Ile Ile Asp Glu Leu Trp His Ser Ser 
                405                 410                 415     


Met Asn Gln Met Glu Val Phe Thr Tyr Leu Asn Met Arg Pro Lys Lys 
            420                 425                 430         


Tyr Glu Leu Lys Gly Tyr Gln Arg Ile Pro Thr Asp Met Ile Asp Asp 
        435                 440                 445             


Ala Ile Leu Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn 
    450                 455                 460                 


Val Ile Asn Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile 
465                 470                 475                 480 


Ile Glu Leu Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile 
                485                 490                 495     


Asn Asn Leu Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu 
            500                 505                 510         


Ile Ile Gly Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys 
        515                 520                 525             


Ile Arg Leu His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu 
    530                 535                 540                 


Ser Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val 
545                 550                 555                 560 


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn 
                565                 570                 575     


Lys Val Leu Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr 
            580                 585                 590         


Pro Tyr Gln Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln 
        595                 600                 605             


Phe Lys Gln His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser 
    610                 615                 620                 


Lys Lys Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe 
625                 630                 635                 640 


Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
                645                 650                 655     


Ala Thr Arg Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn 
            660                 665                 670         


Asn Met Asn Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr 
        675                 680                 685             


Leu Arg Lys Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys 
    690                 695                 700                 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe 
705                 710                 715                 720 


Lys Glu Asn Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro 
                725                 730                 735     


Glu Ile Glu Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn 
            740                 745                 750         


Tyr Ser Glu Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp 
        755                 760                 765             


Phe Arg Asn Phe Lys Phe Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Met Lys Asp Glu His 
785                 790                 795                 800 


Asp Tyr Ile Val Gln Thr Ile Thr Asp Ile Tyr Gly Lys Asp Asn Thr 
                805                 810                 815     


Asn Leu Lys Lys Gln Phe Asn Lys Asn Pro Glu Lys Phe Leu Met Tyr 
            820                 825                 830         


Gln Asn Asp Pro Lys Thr Phe Glu Lys Leu Ser Ile Ile Met Lys Gln 
        835                 840                 845             


Tyr Ser Asp Glu Lys Asn Pro Leu Ala Lys Tyr Tyr Glu Glu Thr Gly 
    850                 855                 860                 


Glu Tyr Leu Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys 
865                 870                 875                 880 


Lys Ile Lys Leu Leu Gly Asn Lys Val Gly Asn His Leu Asp Val Thr 
                885                 890                 895     


Asn Lys Tyr Glu Asn Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            900                 905                 910         


Asn Tyr Arg Phe Asp Val Tyr Leu Thr Glu Lys Gly Tyr Lys Phe Val 
        915                 920                 925             


Thr Ile Ala Tyr Leu Asn Val Phe Lys Lys Asp Asn Tyr Tyr Tyr Ile 
    930                 935                 940                 


Pro Lys Asp Lys Tyr Gln Glu Leu Lys Glu Lys Lys Lys Ile Lys Asp 
945                 950                 955                 960 


Thr Asp Gln Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
                965                 970                 975     


Asn Gly Asp Leu Tyr Lys Ile Ile Gly Val Asn Ser Asp Asp Arg Asn 
            980                 985                 990         


Ile Ile Glu Leu Asp Tyr Tyr Asp  Ile Lys Tyr Lys Asp  Tyr Cys Glu 
        995                 1000                 1005             


Ile Asn  Asn Ile Lys Gly Glu  Pro Arg Ile Lys Lys  Thr Ile Gly 
    1010                 1015                 1020             


Lys Lys  Thr Glu Ser Ile Glu  Lys Phe Thr Thr Asp  Val Leu Gly 
    1025                 1030                 1035             


Asn Leu  Tyr Leu His Ser Thr  Glu Lys Ala Pro Gln  Leu Ile Phe 
    1040                 1045                 1050             


Lys Arg  Gly Leu 
    1055         


<210>  4
<211>  1057
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of Gib11Spa-3

<400>  4

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Leu Leu Leu Thr Glu Tyr Asp Leu Ile Asn Lys Glu 
65                  70                  75                  80  


Gln Ile Pro Thr Ser Asn Asn Pro Tyr Gln Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ile Leu Ser Lys Asp Glu Leu Ala Ile Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu 
        115                 120                 125             


Glu Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn 
    130                 135                 140                 


Ala Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr 
                165                 170                 175     


Lys Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln 
            180                 185                 190         


Tyr Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu 
        195                 200                 205             


Val Glu Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro 
    210                 215                 220                 


Phe Gly Trp Asn Gly Asp Leu Lys Lys Trp Tyr Glu Met Leu Met Gly 
225                 230                 235                 240 


His Cys Thr Tyr Phe Pro Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr 
                245                 250                 255     


Ser Ala Asp Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile 
            260                 265                 270         


Gln Arg Asp Asn Ser Glu Lys Leu Glu Tyr His Glu Lys Tyr His Ile 
        275                 280                 285             


Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile 
    290                 295                 300                 


Ala Lys Glu Ile Gly Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile 
305                 310                 315                 320 


Thr Lys Ser Gly Thr Pro Glu Phe Thr Ser Phe Lys Leu Phe His Asp 
                325                 330                 335     


Leu Lys Lys Val Val Lys Asp His Ala Ile Leu Asp Asp Ile Asp Leu 
            340                 345                 350         


Leu Asn Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser 
        355                 360                 365             


Ile Val Ala Glu Leu Gly Gln Leu Glu Tyr Leu Met Ser Glu Ala Asp 
    370                 375                 380                 


Lys Gln Ser Ile Ser Glu Leu Thr Gly Tyr Thr Gly Thr His Ser Leu 
385                 390                 395                 400 


Ser Leu Lys Cys Met Asn Met Ile Ile Asp Glu Leu Trp His Ser Ser 
                405                 410                 415     


Met Asn Gln Met Glu Val Phe Thr Tyr Leu Asn Met Arg Pro Lys Lys 
            420                 425                 430         


Tyr Glu Leu Lys Gly Tyr Gln Arg Ile Pro Thr Asp Met Ile Asp Asp 
        435                 440                 445             


Ala Ile Leu Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn 
    450                 455                 460                 


Val Ile Asn Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile 
465                 470                 475                 480 


Ile Glu Leu Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile 
                485                 490                 495     


Asn Asn Leu Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu 
            500                 505                 510         


Ile Ile Gly Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys 
        515                 520                 525             


Ile Arg Leu His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu 
    530                 535                 540                 


Ser Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val 
545                 550                 555                 560 


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn 
                565                 570                 575     


Lys Val Leu Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr 
            580                 585                 590         


Pro Tyr Gln Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln 
        595                 600                 605             


Phe Lys Gln His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser 
    610                 615                 620                 


Lys Lys Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe 
625                 630                 635                 640 


Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
                645                 650                 655     


Ala Thr Arg Glu Leu Thr Ser Tyr Leu Lys Ala Tyr Phe Ser Ala Asn 
            660                 665                 670         


Asn Met Asp Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asn His 
        675                 680                 685             


Leu Arg Lys Val Trp Arg Phe Asp Lys Tyr Arg Asn His Gly Tyr Lys 
    690                 695                 700                 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe 
705                 710                 715                 720 


Lys Glu Asn Lys Lys Leu Gln Asn Thr Asn Lys Ile Leu Glu Lys Pro 
                725                 730                 735     


Thr Ile Glu Asn Asn Thr Lys Lys Val Thr Val Glu Lys Glu Glu Asp 
            740                 745                 750         


Tyr Asn Asn Val Phe Glu Thr Pro Lys Leu Val Glu Asp Ile Lys Gln 
        755                 760                 765             


Tyr Arg Asp Tyr Lys Phe Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Met Lys Asp Glu His 
785                 790                 795                 800 


Asp Tyr Ile Val Gln Thr Ile Thr Asp Ile Tyr Gly Lys Asp Asn Thr 
                805                 810                 815     


Asn Leu Lys Lys Gln Phe Asn Lys Asn Pro Glu Lys Phe Leu Met Tyr 
            820                 825                 830         


Gln Asn Asp Pro Lys Thr Phe Glu Lys Leu Ser Ile Ile Met Lys Gln 
        835                 840                 845             


Tyr Ser Asp Glu Lys Asn Pro Leu Ala Lys Tyr Tyr Glu Glu Thr Gly 
    850                 855                 860                 


Glu Tyr Leu Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys 
865                 870                 875                 880 


Lys Ile Lys Leu Leu Gly Asn Lys Val Gly Asn His Leu Asp Val Thr 
                885                 890                 895     


Asn Lys Tyr Glu Asn Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            900                 905                 910         


Asn Tyr Arg Phe Asp Val Tyr Leu Thr Glu Lys Gly Tyr Lys Phe Val 
        915                 920                 925             


Thr Ile Ala Tyr Leu Asn Val Phe Lys Lys Asp Asn Tyr Tyr Tyr Ile 
    930                 935                 940                 


Pro Lys Asp Lys Tyr Gln Glu Leu Lys Glu Lys Lys Lys Ile Lys Asp 
945                 950                 955                 960 


Thr Asp Gln Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
                965                 970                 975     


Asn Gly Asp Leu Tyr Lys Ile Ile Gly Val Asn Ser Asp Asp Arg Asn 
            980                 985                 990         


Ile Ile Glu Leu Asp Tyr Tyr Asp  Ile Lys Tyr Lys Asp  Tyr Cys Glu 
        995                 1000                 1005             


Ile Asn  Asn Ile Lys Gly Glu  Pro Arg Ile Lys Lys  Thr Ile Gly 
    1010                 1015                 1020             


Lys Lys  Thr Glu Ser Ile Glu  Lys Phe Thr Thr Asp  Val Leu Gly 
    1025                 1030                 1035             


Asn Leu  Tyr Leu His Ser Thr  Glu Lys Ala Pro Gln  Leu Ile Phe 
    1040                 1045                 1050             


Lys Arg  Gly Leu 
    1055         


<210>  5
<211>  1054
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of P2H12

<400>  5

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser 
65                  70                  75                  80  


Gln Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Ile Asn Val Ser Ser Glu Asp Glu 
        115                 120                 125             


Asp Ala Ser Asn Glu Leu Ser Thr Lys Glu Gln Ile Asn Arg Asn Asn 
    130                 135                 140                 


Lys Leu Leu Lys Asp Lys Tyr Val Cys Glu Val Gln Leu Gln Arg Leu 
145                 150                 155                 160 


Lys Glu Gly Gln Ile Arg Gly Glu Lys Asn Arg Phe Lys Thr Thr Asp 
                165                 170                 175     


Ile Leu Lys Glu Ile Asp Gln Leu Leu Lys Val Gln Lys Asp Tyr His 
            180                 185                 190         


Asn Leu Asp Ile Asp Phe Ile Asn Gln Tyr Lys Glu Ile Val Glu Thr 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp 
    210                 215                 220                 


Glu Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp 
            260                 265                 270         


Gly Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu 
    290                 295                 300                 


Ile Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser 
305                 310                 315                 320 


Gly Lys Pro Glu Phe Thr Ser Phe Lys Leu Phe His Asp Leu Lys Lys 
                325                 330                 335     


Val Val Lys Asp His Ala Ile Leu Asp Asp Ile Asp Leu Leu Asn Gln 
            340                 345                 350         


Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Val Ala 
        355                 360                 365             


Glu Leu Gly Gln Leu Glu Tyr Leu Met Ser Glu Ala Asp Lys Gln Ser 
    370                 375                 380                 


Ile Ser Glu Leu Thr Gly Tyr Thr Gly Thr His Ser Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Met Asn Met Ile Ile Asp Glu Leu Trp His Ser Ser Met Asn Gln 
                405                 410                 415     


Met Glu Val Phe Thr Tyr Leu Asn Met Arg Pro Lys Lys Tyr Glu Leu 
            420                 425                 430         


Lys Gly Tyr Gln Arg Ile Pro Thr Asp Met Ile Asp Asp Ala Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn Val Ile Asn 
    450                 455                 460                 


Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile Asn Asn Leu 
                485                 490                 495     


Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly 
            500                 505                 510         


Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys Ile Arg Leu 
        515                 520                 525             


His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro 
    530                 535                 540                 


Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu 
                565                 570                 575     


Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys 
    610                 615                 620                 


Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys 
        675                 680                 685             


Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu 
                725                 730                 735     


Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu 
            740                 745                 750         


Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn 
        755                 760                 765             


Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile 
785                 790                 795                 800 


Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys 
                805                 810                 815     


Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp 
            820                 825                 830         


Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn 
        835                 840                 845             


Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys 
865                 870                 875                 880 


Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe 
                885                 890                 895     


Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser 
        915                 920                 925             


Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln 
    930                 935                 940                 


Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu 
                965                 970                 975     


Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu 
            980                 985                 990         


Leu Asp Leu Pro Asp Ile Arg Tyr  Lys Glu Tyr Cys Glu  Leu Asn Asn 
        995                 1000                 1005             


Ile Lys  Gly Glu Pro Arg Ile  Lys Lys Thr Ile Gly  Lys Lys Val 
    1010                 1015                 1020             


Asn Ser  Ile Glu Lys Leu Thr  Thr Asp Val Leu Gly  Asn Val Phe 
    1025                 1030                 1035             


Thr Asn  Thr Gln Tyr Thr Lys  Pro Gln Leu Leu Phe  Lys Arg Gly 
    1040                 1045                 1050             


Asn 
    


<210>  6
<211>  1057
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of E2

<400>  6

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Asp Arg Val Lys His Leu Leu Ala Glu Tyr Asp Leu Leu Asp Leu Thr 
65                  70                  75                  80  


Asn Ile Pro Lys Ser Thr Asn Pro Tyr Gln Thr Arg Val Lys Gly Leu 
                85                  90                  95      


Asn Glu Lys Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu 
        115                 120                 125             


Glu Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn 
    130                 135                 140                 


Ala Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr 
                165                 170                 175     


Lys Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln 
            180                 185                 190         


Tyr Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu 
        195                 200                 205             


Val Glu Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro 
    210                 215                 220                 


Phe Gly Trp Glu Gly Asn Ile Lys Lys Trp Phe Glu Gln Met Met Gly 
225                 230                 235                 240 


His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ser Tyr 
                245                 250                 255     


Ser Ala Glu Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile 
            260                 265                 270         


Thr Arg Asp Glu Asp Ala Lys Leu Asn Tyr Gly Glu Lys Phe Gln Ile 
        275                 280                 285             


Ile Glu Asn Val Phe Lys Gln Lys Lys Thr Pro Asn Leu Lys Gln Ile 
    290                 295                 300                 


Ala Ile Glu Ile Gly Val His Glu Thr Glu Ile Lys Gly Tyr Arg Val 
305                 310                 315                 320 


Asn Lys Ser Gly Thr Pro Glu Phe Thr Glu Phe Lys Leu Tyr His Asp 
                325                 330                 335     


Leu Lys Ser Ile Val Phe Asp Lys Ser Ile Leu Glu Asn Glu Ala Ile 
            340                 345                 350         


Leu Asp Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Glu Gln Ser 
        355                 360                 365             


Ile Lys Glu Glu Leu Asn Lys Leu Pro Glu Ile Leu Asn Glu Gln Asp 
    370                 375                 380                 


Lys Ala Glu Ile Ala Lys Leu Ile Gly Tyr Asn Gly Thr His Arg Leu 
385                 390                 395                 400 


Ser Leu Lys Cys Ile His Leu Ile Asn Glu Glu Leu Trp Gln Thr Ser 
                405                 410                 415     


Arg Asn Gln Met Glu Ile Phe Asn Tyr Leu Asn Ile Lys Pro Asn Lys 
            420                 425                 430         


Val Asp Leu Ser Glu Gln Asn Lys Ile Pro Lys Asp Met Val Asn Asp 
        435                 440                 445             


Phe Ile Leu Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn 
    450                 455                 460                 


Val Ile Asn Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile 
465                 470                 475                 480 


Ile Glu Leu Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile 
                485                 490                 495     


Asn Asn Leu Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu 
            500                 505                 510         


Ile Ile Gly Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys 
        515                 520                 525             


Ile Arg Leu His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Lys 
    530                 535                 540                 


Asp Ile Pro Leu Glu Asp Leu Leu Arg Asn Pro Asn Asn Tyr Asp Ile 
545                 550                 555                 560 


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asp Ser Met His Asn 
                565                 570                 575     


Lys Val Leu Val Arg Arg Glu Gln Asn Ala Lys Lys Asn Asn Gln Thr 
            580                 585                 590         


Pro Tyr Gln Tyr Leu Thr Ser Gly Tyr Ala Asp Ile Lys Tyr Ser Val 
        595                 600                 605             


Phe Lys Gln His Val Leu Asn Leu Ala Glu Asn Lys Asp Arg Met Thr 
    610                 615                 620                 


Lys Lys Lys Arg Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe 
625                 630                 635                 640 


Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
                645                 650                 655     


Ala Thr Arg Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn 
            660                 665                 670         


Asn Met Asn Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr 
        675                 680                 685             


Leu Arg Lys Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys 
    690                 695                 700                 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe 
705                 710                 715                 720 


Lys Glu Asn Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro 
                725                 730                 735     


Glu Ile Glu Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn 
            740                 745                 750         


Tyr Ser Glu Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp 
        755                 760                 765             


Phe Arg Asn Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser 
785                 790                 795                 800 


Thr Tyr Ile Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr 
                805                 810                 815     


Thr Leu Lys Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr 
            820                 825                 830         


Gln His Asp Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln 
        835                 840                 845             


Tyr Ala Asn Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly 
    850                 855                 860                 


Glu Tyr Leu Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys 
865                 870                 875                 880 


Ser Leu Lys Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr 
                885                 890                 895     


His Gln Phe Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            900                 905                 910         


Pro Tyr Arg Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile 
        915                 920                 925             


Thr Ile Ser Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile 
    930                 935                 940                 


Pro Glu Gln Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys 
945                 950                 955                 960 


Asn Ala Lys Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
                965                 970                 975     


Asp Gly Glu Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn 
            980                 985                 990         


Met Ile Glu Leu Asp Leu Pro Asp  Ile Arg Tyr Lys Glu  Tyr Cys Glu 
        995                 1000                 1005             


Leu Asn  Asn Ile Lys Gly Glu  Pro Arg Ile Lys Lys  Thr Ile Gly 
    1010                 1015                 1020             


Lys Lys  Val Asn Ser Ile Glu  Lys Leu Thr Thr Asp  Val Leu Gly 
    1025                 1030                 1035             


Asn Val  Phe Thr Asn Thr Gln  Tyr Thr Lys Pro Gln  Leu Leu Phe 
    1040                 1045                 1050             


Lys Arg  Gly Asn 
    1055         


<210>  7
<211>  1057
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of E2-K741D-L743K

<400>  7

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Asp Arg Val Lys His Leu Leu Ala Glu Tyr Asp Leu Leu Asp Leu Thr 
65                  70                  75                  80  


Asn Ile Pro Lys Ser Thr Asn Pro Tyr Gln Thr Arg Val Lys Gly Leu 
                85                  90                  95      


Asn Glu Lys Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu 
        115                 120                 125             


Glu Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn 
    130                 135                 140                 


Ala Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr 
                165                 170                 175     


Lys Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln 
            180                 185                 190         


Tyr Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu 
        195                 200                 205             


Val Glu Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro 
    210                 215                 220                 


Phe Gly Trp Glu Gly Asn Ile Lys Lys Trp Phe Glu Gln Met Met Gly 
225                 230                 235                 240 


His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ser Tyr 
                245                 250                 255     


Ser Ala Glu Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile 
            260                 265                 270         


Thr Arg Asp Glu Asp Ala Lys Leu Asn Tyr Gly Glu Lys Phe Gln Ile 
        275                 280                 285             


Ile Glu Asn Val Phe Lys Gln Lys Lys Thr Pro Asn Leu Lys Gln Ile 
    290                 295                 300                 


Ala Ile Glu Ile Gly Val His Glu Thr Glu Ile Lys Gly Tyr Arg Val 
305                 310                 315                 320 


Asn Lys Ser Gly Thr Pro Glu Phe Thr Glu Phe Lys Leu Tyr His Asp 
                325                 330                 335     


Leu Lys Ser Ile Val Phe Asp Lys Ser Ile Leu Glu Asn Glu Ala Ile 
            340                 345                 350         


Leu Asp Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Glu Gln Ser 
        355                 360                 365             


Ile Lys Glu Glu Leu Asn Lys Leu Pro Glu Ile Leu Asn Glu Gln Asp 
    370                 375                 380                 


Lys Ala Glu Ile Ala Lys Leu Ile Gly Tyr Asn Gly Thr His Arg Leu 
385                 390                 395                 400 


Ser Leu Lys Cys Ile His Leu Ile Asn Glu Glu Leu Trp Gln Thr Ser 
                405                 410                 415     


Arg Asn Gln Met Glu Ile Phe Asn Tyr Leu Asn Ile Lys Pro Asn Lys 
            420                 425                 430         


Val Asp Leu Ser Glu Gln Asn Lys Ile Pro Lys Asp Met Val Asn Asp 
        435                 440                 445             


Phe Ile Leu Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn 
    450                 455                 460                 


Val Ile Asn Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile 
465                 470                 475                 480 


Ile Glu Leu Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile 
                485                 490                 495     


Asn Asn Leu Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu 
            500                 505                 510         


Ile Ile Gly Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys 
        515                 520                 525             


Ile Arg Leu His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Lys 
    530                 535                 540                 


Asp Ile Pro Leu Glu Asp Leu Leu Arg Asn Pro Asn Asn Tyr Asp Ile 
545                 550                 555                 560 


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asp Ser Met His Asn 
                565                 570                 575     


Lys Val Leu Val Arg Arg Glu Gln Asn Ala Lys Lys Asn Asn Gln Thr 
            580                 585                 590         


Pro Tyr Gln Tyr Leu Thr Ser Gly Tyr Ala Asp Ile Lys Tyr Ser Val 
        595                 600                 605             


Phe Lys Gln His Val Leu Asn Leu Ala Glu Asn Lys Asp Arg Met Thr 
    610                 615                 620                 


Lys Lys Lys Arg Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe 
625                 630                 635                 640 


Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
                645                 650                 655     


Ala Thr Arg Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn 
            660                 665                 670         


Asn Met Asn Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr 
        675                 680                 685             


Leu Arg Lys Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys 
    690                 695                 700                 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe 
705                 710                 715                 720 


Lys Glu Asn Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro 
                725                 730                 735     


Glu Ile Glu Thr Asp Gln Lys Asp Ile Gln Val Asp Ser Glu Asp Asn 
            740                 745                 750         


Tyr Ser Glu Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp 
        755                 760                 765             


Phe Arg Asn Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser 
785                 790                 795                 800 


Thr Tyr Ile Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr 
                805                 810                 815     


Thr Leu Lys Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr 
            820                 825                 830         


Gln His Asp Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln 
        835                 840                 845             


Tyr Ala Asn Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly 
    850                 855                 860                 


Glu Tyr Leu Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys 
865                 870                 875                 880 


Ser Leu Lys Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr 
                885                 890                 895     


His Gln Phe Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            900                 905                 910         


Pro Tyr Arg Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile 
        915                 920                 925             


Thr Ile Ser Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile 
    930                 935                 940                 


Pro Glu Gln Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys 
945                 950                 955                 960 


Asn Ala Lys Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
                965                 970                 975     


Asp Gly Glu Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn 
            980                 985                 990         


Met Ile Glu Leu Asp Leu Pro Asp  Ile Arg Tyr Lys Glu  Tyr Cys Glu 
        995                 1000                 1005             


Leu Asn  Asn Ile Lys Gly Glu  Pro Arg Ile Lys Lys  Thr Ile Gly 
    1010                 1015                 1020             


Lys Lys  Val Asn Ser Ile Glu  Lys Leu Thr Thr Asp  Val Leu Gly 
    1025                 1030                 1035             


Asn Val  Phe Thr Asn Thr Gln  Tyr Thr Lys Pro Gln  Leu Leu Phe 
    1040                 1045                 1050             


Lys Arg  Gly Asn 
    1055         


<210>  8
<211>  1057
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of E2-S670T-N675D

<400>  8

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Asp Arg Val Lys His Leu Leu Ala Glu Tyr Asp Leu Leu Asp Leu Thr 
65                  70                  75                  80  


Asn Ile Pro Lys Ser Thr Asn Pro Tyr Gln Thr Arg Val Lys Gly Leu 
                85                  90                  95      


Asn Glu Lys Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu 
        115                 120                 125             


Glu Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn 
    130                 135                 140                 


Ala Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr 
                165                 170                 175     


Lys Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln 
            180                 185                 190         


Tyr Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu 
        195                 200                 205             


Val Glu Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro 
    210                 215                 220                 


Phe Gly Trp Glu Gly Asn Ile Lys Lys Trp Phe Glu Gln Met Met Gly 
225                 230                 235                 240 


His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ser Tyr 
                245                 250                 255     


Ser Ala Glu Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile 
            260                 265                 270         


Thr Arg Asp Glu Asp Ala Lys Leu Asn Tyr Gly Glu Lys Phe Gln Ile 
        275                 280                 285             


Ile Glu Asn Val Phe Lys Gln Lys Lys Thr Pro Asn Leu Lys Gln Ile 
    290                 295                 300                 


Ala Ile Glu Ile Gly Val His Glu Thr Glu Ile Lys Gly Tyr Arg Val 
305                 310                 315                 320 


Asn Lys Ser Gly Thr Pro Glu Phe Thr Glu Phe Lys Leu Tyr His Asp 
                325                 330                 335     


Leu Lys Ser Ile Val Phe Asp Lys Ser Ile Leu Glu Asn Glu Ala Ile 
            340                 345                 350         


Leu Asp Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Glu Gln Ser 
        355                 360                 365             


Ile Lys Glu Glu Leu Asn Lys Leu Pro Glu Ile Leu Asn Glu Gln Asp 
    370                 375                 380                 


Lys Ala Glu Ile Ala Lys Leu Ile Gly Tyr Asn Gly Thr His Arg Leu 
385                 390                 395                 400 


Ser Leu Lys Cys Ile His Leu Ile Asn Glu Glu Leu Trp Gln Thr Ser 
                405                 410                 415     


Arg Asn Gln Met Glu Ile Phe Asn Tyr Leu Asn Ile Lys Pro Asn Lys 
            420                 425                 430         


Val Asp Leu Ser Glu Gln Asn Lys Ile Pro Lys Asp Met Val Asn Asp 
        435                 440                 445             


Phe Ile Leu Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn 
    450                 455                 460                 


Val Ile Asn Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile 
465                 470                 475                 480 


Ile Glu Leu Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile 
                485                 490                 495     


Asn Asn Leu Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu 
            500                 505                 510         


Ile Ile Gly Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys 
        515                 520                 525             


Ile Arg Leu His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Lys 
    530                 535                 540                 


Asp Ile Pro Leu Glu Asp Leu Leu Arg Asn Pro Asn Asn Tyr Asp Ile 
545                 550                 555                 560 


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asp Ser Met His Asn 
                565                 570                 575     


Lys Val Leu Val Arg Arg Glu Gln Asn Ala Lys Lys Asn Asn Gln Thr 
            580                 585                 590         


Pro Tyr Gln Tyr Leu Thr Ser Gly Tyr Ala Asp Ile Lys Tyr Ser Val 
        595                 600                 605             


Phe Lys Gln His Val Leu Asn Leu Ala Glu Asn Lys Asp Arg Met Thr 
    610                 615                 620                 


Lys Lys Lys Arg Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe 
625                 630                 635                 640 


Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
                645                 650                 655     


Ala Thr Arg Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Thr Ala Asn 
            660                 665                 670         


Asn Met Asp Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr 
        675                 680                 685             


Leu Arg Lys Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys 
    690                 695                 700                 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe 
705                 710                 715                 720 


Lys Glu Asn Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro 
                725                 730                 735     


Glu Ile Glu Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn 
            740                 745                 750         


Tyr Ser Glu Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp 
        755                 760                 765             


Phe Arg Asn Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser 
785                 790                 795                 800 


Thr Tyr Ile Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr 
                805                 810                 815     


Thr Leu Lys Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr 
            820                 825                 830         


Gln His Asp Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln 
        835                 840                 845             


Tyr Ala Asn Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly 
    850                 855                 860                 


Glu Tyr Leu Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys 
865                 870                 875                 880 


Ser Leu Lys Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr 
                885                 890                 895     


His Gln Phe Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            900                 905                 910         


Pro Tyr Arg Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile 
        915                 920                 925             


Thr Ile Ser Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile 
    930                 935                 940                 


Pro Glu Gln Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys 
945                 950                 955                 960 


Asn Ala Lys Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
                965                 970                 975     


Asp Gly Glu Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn 
            980                 985                 990         


Met Ile Glu Leu Asp Leu Pro Asp  Ile Arg Tyr Lys Glu  Tyr Cys Glu 
        995                 1000                 1005             


Leu Asn  Asn Ile Lys Gly Glu  Pro Arg Ile Lys Lys  Thr Ile Gly 
    1010                 1015                 1020             


Lys Lys  Val Asn Ser Ile Glu  Lys Leu Thr Thr Asp  Val Leu Gly 
    1025                 1030                 1035             


Asn Val  Phe Thr Asn Thr Gln  Tyr Thr Lys Pro Gln  Leu Leu Phe 
    1040                 1045                 1050             


Lys Arg  Gly Asn 
    1055         


<210>  9
<211>  1057
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of E2-K741N-L743N

<400>  9

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Asp Arg Val Lys His Leu Leu Ala Glu Tyr Asp Leu Leu Asp Leu Thr 
65                  70                  75                  80  


Asn Ile Pro Lys Ser Thr Asn Pro Tyr Gln Thr Arg Val Lys Gly Leu 
                85                  90                  95      


Asn Glu Lys Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu 
        115                 120                 125             


Glu Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn 
    130                 135                 140                 


Ala Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr 
                165                 170                 175     


Lys Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln 
            180                 185                 190         


Tyr Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu 
        195                 200                 205             


Val Glu Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro 
    210                 215                 220                 


Phe Gly Trp Glu Gly Asn Ile Lys Lys Trp Phe Glu Gln Met Met Gly 
225                 230                 235                 240 


His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ser Tyr 
                245                 250                 255     


Ser Ala Glu Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile 
            260                 265                 270         


Thr Arg Asp Glu Asp Ala Lys Leu Asn Tyr Gly Glu Lys Phe Gln Ile 
        275                 280                 285             


Ile Glu Asn Val Phe Lys Gln Lys Lys Thr Pro Asn Leu Lys Gln Ile 
    290                 295                 300                 


Ala Ile Glu Ile Gly Val His Glu Thr Glu Ile Lys Gly Tyr Arg Val 
305                 310                 315                 320 


Asn Lys Ser Gly Thr Pro Glu Phe Thr Glu Phe Lys Leu Tyr His Asp 
                325                 330                 335     


Leu Lys Ser Ile Val Phe Asp Lys Ser Ile Leu Glu Asn Glu Ala Ile 
            340                 345                 350         


Leu Asp Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Glu Gln Ser 
        355                 360                 365             


Ile Lys Glu Glu Leu Asn Lys Leu Pro Glu Ile Leu Asn Glu Gln Asp 
    370                 375                 380                 


Lys Ala Glu Ile Ala Lys Leu Ile Gly Tyr Asn Gly Thr His Arg Leu 
385                 390                 395                 400 


Ser Leu Lys Cys Ile His Leu Ile Asn Glu Glu Leu Trp Gln Thr Ser 
                405                 410                 415     


Arg Asn Gln Met Glu Ile Phe Asn Tyr Leu Asn Ile Lys Pro Asn Lys 
            420                 425                 430         


Val Asp Leu Ser Glu Gln Asn Lys Ile Pro Lys Asp Met Val Asn Asp 
        435                 440                 445             


Phe Ile Leu Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn 
    450                 455                 460                 


Val Ile Asn Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile 
465                 470                 475                 480 


Ile Glu Leu Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile 
                485                 490                 495     


Asn Asn Leu Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu 
            500                 505                 510         


Ile Ile Gly Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys 
        515                 520                 525             


Ile Arg Leu His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Lys 
    530                 535                 540                 


Asp Ile Pro Leu Glu Asp Leu Leu Arg Asn Pro Asn Asn Tyr Asp Ile 
545                 550                 555                 560 


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asp Ser Met His Asn 
                565                 570                 575     


Lys Val Leu Val Arg Arg Glu Gln Asn Ala Lys Lys Asn Asn Gln Thr 
            580                 585                 590         


Pro Tyr Gln Tyr Leu Thr Ser Gly Tyr Ala Asp Ile Lys Tyr Ser Val 
        595                 600                 605             


Phe Lys Gln His Val Leu Asn Leu Ala Glu Asn Lys Asp Arg Met Thr 
    610                 615                 620                 


Lys Lys Lys Arg Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe 
625                 630                 635                 640 


Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
                645                 650                 655     


Ala Thr Arg Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn 
            660                 665                 670         


Asn Met Asn Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr 
        675                 680                 685             


Leu Arg Lys Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys 
    690                 695                 700                 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe 
705                 710                 715                 720 


Lys Glu Asn Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro 
                725                 730                 735     


Glu Ile Glu Thr Asn Gln Asn Asp Ile Gln Val Asp Ser Glu Asp Asn 
            740                 745                 750         


Tyr Ser Glu Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp 
        755                 760                 765             


Phe Arg Asn Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
    770                 775                 780                 


Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser 
785                 790                 795                 800 


Thr Tyr Ile Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr 
                805                 810                 815     


Thr Leu Lys Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr 
            820                 825                 830         


Gln His Asp Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln 
        835                 840                 845             


Tyr Ala Asn Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly 
    850                 855                 860                 


Glu Tyr Leu Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys 
865                 870                 875                 880 


Ser Leu Lys Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr 
                885                 890                 895     


His Gln Phe Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            900                 905                 910         


Pro Tyr Arg Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile 
        915                 920                 925             


Thr Ile Ser Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile 
    930                 935                 940                 


Pro Glu Gln Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys 
945                 950                 955                 960 


Asn Ala Lys Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
                965                 970                 975     


Asp Gly Glu Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn 
            980                 985                 990         


Met Ile Glu Leu Asp Leu Pro Asp  Ile Arg Tyr Lys Glu  Tyr Cys Glu 
        995                 1000                 1005             


Leu Asn  Asn Ile Lys Gly Glu  Pro Arg Ile Lys Lys  Thr Ile Gly 
    1010                 1015                 1020             


Lys Lys  Val Asn Ser Ile Glu  Lys Leu Thr Thr Asp  Val Leu Gly 
    1025                 1030                 1035             


Asn Val  Phe Thr Asn Thr Gln  Tyr Thr Lys Pro Gln  Leu Leu Phe 
    1040                 1045                 1050             


Lys Arg  Gly Asn 
    1055         


<210>  10
<211>  1053
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of F8

<400>  10

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Ser Leu Leu Ser Glu Tyr Lys Ile Ile Ser Gly Leu 
65                  70                  75                  80  


Ala Pro Thr Asn Asn Gln Pro Tyr Asn Ile Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Lys Asp Glu Leu Ala Val Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp Asp 
        115                 120                 125             


Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser Lys 
    130                 135                 140                 


Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met Asn 
145                 150                 155                 160 


Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp Ile 
                165                 170                 175     


Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His Gln 
            180                 185                 190         


Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met Arg 
        195                 200                 205             


Arg Glu Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro Phe Gly Trp Asn 
    210                 215                 220                 


Gly Asp Leu Lys Lys Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu 
                245                 250                 255     


Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile Gln Arg Asp Asn 
            260                 265                 270         


Ser Glu Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile 
    290                 295                 300                 


Gly Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly 
305                 310                 315                 320 


Thr Pro Glu Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Val 
                325                 330                 335     


Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln Ile 
            340                 345                 350         


Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser Lys 
        355                 360                 365             


Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn Ile 
    370                 375                 380                 


Ala Gln Leu Thr Gly Tyr Asn Gly Thr His Arg Leu Ser Leu Lys Cys 
385                 390                 395                 400 


Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln Met 
                405                 410                 415     


Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu Thr 
            420                 425                 430         


Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn Val Ile Asn Lys 
    450                 455                 460                 


Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile Asn Asn Leu Gln 
                485                 490                 495     


Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Gln 
            500                 505                 510         


Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys Ile Arg Leu His 
        515                 520                 525             


Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Ala Leu 
    530                 535                 540                 


Met Asp Leu Leu Asn Asn Pro Gln Asn Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ala Phe Asp Asn Ser Ile His Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Ile Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Tyr Gln Tyr 
            580                 585                 590         


Leu Asn Ser Ser Asp Ala Lys Leu Ser Tyr Asn Gln Phe Lys Gln His 
        595                 600                 605             


Ile Leu Asn Leu Ser Lys Ser Lys Asp Arg Ile Ser Lys Lys Lys Lys 
    610                 615                 620                 


Asp Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln Lys 
625                 630                 635                 640 


Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Glu 
                645                 650                 655     


Leu Thr Ser Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asp Val 
            660                 665                 670         


Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asn His Leu Arg Lys Val 
        675                 680                 685             


Trp Arg Phe Asp Lys Tyr Arg Asn His Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys 
705                 710                 715                 720 


Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu Thr 
                725                 730                 735     


Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu Met 
            740                 745                 750         


Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn Phe 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile Val 
785                 790                 795                 800 


Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys Lys 
                805                 810                 815     


Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp Pro 
            820                 825                 830         


Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn Glu 
        835                 840                 845             


Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu Thr 
    850                 855                 860                 


Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys Tyr 
865                 870                 875                 880 


Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe Lys 
                885                 890                 895     


Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg Phe 
            900                 905                 910         


Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser Tyr 
        915                 920                 925             


Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln Lys 
    930                 935                 940                 


Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys Phe 
945                 950                 955                 960 


Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu Ile 
                965                 970                 975     


Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu Leu 
            980                 985                 990         


Asp Leu Pro Asp Ile Arg Tyr Lys  Glu Tyr Cys Glu Leu  Asn Asn Ile 
        995                 1000                 1005             


Lys Gly  Glu Pro Arg Ile Lys  Lys Thr Ile Gly Lys  Lys Val Asn 
    1010                 1015                 1020             


Ser Ile  Glu Lys Leu Thr Thr  Asp Val Leu Gly Asn  Val Phe Thr 
    1025                 1030                 1035             


Asn Thr  Gln Tyr Thr Lys Pro  Gln Leu Leu Phe Lys  Arg Gly Asn 
    1040                 1045                 1050             


<210>  11
<211>  1053
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of F8-K737D-L739K

<400>  11

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Ser Leu Leu Ser Glu Tyr Lys Ile Ile Ser Gly Leu 
65                  70                  75                  80  


Ala Pro Thr Asn Asn Gln Pro Tyr Asn Ile Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Lys Asp Glu Leu Ala Val Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp Asp 
        115                 120                 125             


Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser Lys 
    130                 135                 140                 


Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met Asn 
145                 150                 155                 160 


Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp Ile 
                165                 170                 175     


Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His Gln 
            180                 185                 190         


Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met Arg 
        195                 200                 205             


Arg Glu Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro Phe Gly Trp Asn 
    210                 215                 220                 


Gly Asp Leu Lys Lys Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu 
                245                 250                 255     


Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile Gln Arg Asp Asn 
            260                 265                 270         


Ser Glu Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile 
    290                 295                 300                 


Gly Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly 
305                 310                 315                 320 


Thr Pro Glu Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Val 
                325                 330                 335     


Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln Ile 
            340                 345                 350         


Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser Lys 
        355                 360                 365             


Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn Ile 
    370                 375                 380                 


Ala Gln Leu Thr Gly Tyr Asn Gly Thr His Arg Leu Ser Leu Lys Cys 
385                 390                 395                 400 


Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln Met 
                405                 410                 415     


Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu Thr 
            420                 425                 430         


Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn Val Ile Asn Lys 
    450                 455                 460                 


Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile Asn Asn Leu Gln 
                485                 490                 495     


Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Gln 
            500                 505                 510         


Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys Ile Arg Leu His 
        515                 520                 525             


Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Ala Leu 
    530                 535                 540                 


Met Asp Leu Leu Asn Asn Pro Gln Asn Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ala Phe Asp Asn Ser Ile His Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Ile Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Tyr Gln Tyr 
            580                 585                 590         


Leu Asn Ser Ser Asp Ala Lys Leu Ser Tyr Asn Gln Phe Lys Gln His 
        595                 600                 605             


Ile Leu Asn Leu Ser Lys Ser Lys Asp Arg Ile Ser Lys Lys Lys Lys 
    610                 615                 620                 


Asp Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln Lys 
625                 630                 635                 640 


Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Glu 
                645                 650                 655     


Leu Thr Ser Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asp Val 
            660                 665                 670         


Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asn His Leu Arg Lys Val 
        675                 680                 685             


Trp Arg Phe Asp Lys Tyr Arg Asn His Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys 
705                 710                 715                 720 


Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu Thr 
                725                 730                 735     


Asp Gln Lys Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu Met 
            740                 745                 750         


Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn Phe 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile Val 
785                 790                 795                 800 


Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys Lys 
                805                 810                 815     


Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp Pro 
            820                 825                 830         


Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn Glu 
        835                 840                 845             


Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu Thr 
    850                 855                 860                 


Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys Tyr 
865                 870                 875                 880 


Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe Lys 
                885                 890                 895     


Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg Phe 
            900                 905                 910         


Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser Tyr 
        915                 920                 925             


Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln Lys 
    930                 935                 940                 


Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys Phe 
945                 950                 955                 960 


Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu Ile 
                965                 970                 975     


Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu Leu 
            980                 985                 990         


Asp Leu Pro Asp Ile Arg Tyr Lys  Glu Tyr Cys Glu Leu  Asn Asn Ile 
        995                 1000                 1005             


Lys Gly  Glu Pro Arg Ile Lys  Lys Thr Ile Gly Lys  Lys Val Asn 
    1010                 1015                 1020             


Ser Ile  Glu Lys Leu Thr Thr  Asp Val Leu Gly Asn  Val Phe Thr 
    1025                 1030                 1035             


Asn Thr  Gln Tyr Thr Lys Pro  Gln Leu Leu Phe Lys  Arg Gly Asn 
    1040                 1045                 1050             


<210>  12
<211>  1053
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Polypeptide sequence of F8-K737N-L739N

<400>  12

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Ser Leu Leu Ser Glu Tyr Lys Ile Ile Ser Gly Leu 
65                  70                  75                  80  


Ala Pro Thr Asn Asn Gln Pro Tyr Asn Ile Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Lys Asp Glu Leu Ala Val Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp Asp 
        115                 120                 125             


Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser Lys 
    130                 135                 140                 


Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met Asn 
145                 150                 155                 160 


Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp Ile 
                165                 170                 175     


Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His Gln 
            180                 185                 190         


Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met Arg 
        195                 200                 205             


Arg Glu Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro Phe Gly Trp Asn 
    210                 215                 220                 


Gly Asp Leu Lys Lys Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu 
                245                 250                 255     


Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile Gln Arg Asp Asn 
            260                 265                 270         


Ser Glu Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile 
    290                 295                 300                 


Gly Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly 
305                 310                 315                 320 


Thr Pro Glu Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Val 
                325                 330                 335     


Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln Ile 
            340                 345                 350         


Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser Lys 
        355                 360                 365             


Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn Ile 
    370                 375                 380                 


Ala Gln Leu Thr Gly Tyr Asn Gly Thr His Arg Leu Ser Leu Lys Cys 
385                 390                 395                 400 


Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln Met 
                405                 410                 415     


Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu Thr 
            420                 425                 430         


Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn Val Ile Asn Lys 
    450                 455                 460                 


Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile Asn Asn Leu Gln 
                485                 490                 495     


Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Gln 
            500                 505                 510         


Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys Ile Arg Leu His 
        515                 520                 525             


Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Ala Leu 
    530                 535                 540                 


Met Asp Leu Leu Asn Asn Pro Gln Asn Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ala Phe Asp Asn Ser Ile His Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Ile Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Tyr Gln Tyr 
            580                 585                 590         


Leu Asn Ser Ser Asp Ala Lys Leu Ser Tyr Asn Gln Phe Lys Gln His 
        595                 600                 605             


Ile Leu Asn Leu Ser Lys Ser Lys Asp Arg Ile Ser Lys Lys Lys Lys 
    610                 615                 620                 


Asp Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln Lys 
625                 630                 635                 640 


Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Glu 
                645                 650                 655     


Leu Thr Ser Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asp Val 
            660                 665                 670         


Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asn His Leu Arg Lys Val 
        675                 680                 685             


Trp Arg Phe Asp Lys Tyr Arg Asn His Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys 
705                 710                 715                 720 


Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu Thr 
                725                 730                 735     


Asn Gln Asn Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu Met 
            740                 745                 750         


Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn Phe 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile Val 
785                 790                 795                 800 


Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys Lys 
                805                 810                 815     


Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp Pro 
            820                 825                 830         


Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn Glu 
        835                 840                 845             


Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu Thr 
    850                 855                 860                 


Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys Tyr 
865                 870                 875                 880 


Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe Lys 
                885                 890                 895     


Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg Phe 
            900                 905                 910         


Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser Tyr 
        915                 920                 925             


Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln Lys 
    930                 935                 940                 


Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys Phe 
945                 950                 955                 960 


Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu Ile 
                965                 970                 975     


Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu Leu 
            980                 985                 990         


Asp Leu Pro Asp Ile Arg Tyr Lys  Glu Tyr Cys Glu Leu  Asn Asn Ile 
        995                 1000                 1005             


Lys Gly  Glu Pro Arg Ile Lys  Lys Thr Ile Gly Lys  Lys Val Asn 
    1010                 1015                 1020             


Ser Ile  Glu Lys Leu Thr Thr  Asp Val Leu Gly Asn  Val Phe Thr 
    1025                 1030                 1035             


Asn Thr  Gln Tyr Thr Lys Pro  Gln Leu Leu Phe Lys  Arg Gly Asn 
    1040                 1045                 1050             


<210>  13
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding Gib11

<400>  13
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggaacgtgt taaactgctg ctgaccgaat atgatctgat taacaaagag      240

cagattccga ccagcaataa cccgtatcag attcgtgtta aaggtctgag cgaaatcctg      300

agcaaagatg aactggcaat tgcactgctg catctggcaa aacgccgtgg cattcataat      360

gttgatgttg cagcagataa agaagaaacc gcaagcgata gcctgagcac caaagatcag      420

attaacaaaa acgccaaatt tctggaaagc cgctatgttt gtgaactgca gaaagaacgt      480

ctggaaaatg aaggtcatgt tcgtggtgtt gaaaatcgct ttctgacgaa agatattgtg      540

cgtgaggcca aaaaaatcat cgatacccag atgcagtatt acccggaaat tgatgaaacc      600

ttcaaagaga aatatatcag cctggttgaa acccgtcgcg aatattttga aggtcctggt      660

cagggtagcc cgtttggttg gaatggtgat ctgaaaaaat ggtacgaaat gctgatgggt      720

cactgtacct attttccgca agaactgcgt agcgttaaat atgcctatag cgcagacctg      780

tttaatgcac tgaatgatct gaacaacctg attattcagc gcgataatag cgagaaactg      840

gaataccatg agaagtatca catcatcgag aacgtgttca agcagaaaaa aaagccgacg      900

ctgaaacaaa tcgcaaaaga gattggcgtt aacccggaag atattaaagg ttatcgtatt      960

accaaaagcg gcacaccgga gtttacatcc tttaaactgt tccacgatct gaaaaaagtg     1020

gtgaaagatc atgccatcct ggatgatatt gatctgctga atcagattgc agaaatcctg     1080

accatctatc aggataaaga tagcattgtt gcagaactgg gtcagctgga atatctgatg     1140

agcgaagccg ataaacagag cattagcgaa ctgaccggtt ataccggtac acatagcctg     1200

tcactgaaat gcatgaacat gattatcgat gaactgtggc atagcagcat gaaccagatg     1260

gaagttttta cctatctgaa tatgcgtccg aaaaagtatg agctgaaagg ttatcagcgt     1320

attccgaccg atatgattga tgatgcaatt ctgagtccgg ttgtgaaacg cacctttatt     1380

cagagcatca acgtgatcaa caaagtgatc gagaaatatg gcatccccga agatatcatt     1440

atcgaactgg cacgtgaaaa taactccgat gatcgcaaaa agttcatcaa caacctgcag     1500

aaaaagaatg aagcaacccg caaacgcatt aacgaaatta ttggtcagac cggtaatcag     1560

aatgccaaac gtattgtgga aaaaatccgt ctgcatgatc agcaagaggg caaatgtctg     1620

tatagcctgg aaagcattcc tctggaagat ctgctgaaca atccgaatca ttatgaagtg     1680

gatcacatta ttccgcgtag cgtgagcttt gataattcct atcataataa agtgctggtg     1740

aaacagagcg aaaactccaa aaaatccaac ctgacaccgt atcagtattt caatagcggc     1800

aaatccaaac tgagctacaa ccagtttaaa cagcatattc tgaacctgag caaaagccag     1860

gatcgcatca gcaagaagaa gaaggagtac ctgctggaag aacgcgacat caacaaattt     1920

gaagtgcaga aagaatttat caaccgcaac ctggttgata cccgttatgc aacccgtgaa     1980

ctgaccaatt atctgaaagc atatttcagc gccaacaaca tgaacgtgaa agtgaaaacg     2040

attaacggca gctttaccga ttatctgcgt aaagtgtgga aattcaaaaa agaacgcaac     2100

cacggctata aacatcatgc cgaagatgcc ctgattattg caaatgcaga tttcctgttt     2160

aaagaaaaca aaaaactgaa agccgtcaac agcgtgctgg aaaaaccgga aattgagaca     2220

aaacagctgg acattcaggt tgatagcgaa gataattaca gcgaaatgtt tatcatcccg     2280

aaacaggtgc aggatatcaa agattttcgc aacttcaaat atagccaccg cgttgacaaa     2340

aaacctaatc gtcagctgat taacgatacc ctgtatagca cccgcaaaaa agataacagc     2400

acctatattg tgcagaccat taaagacatc tacgccaaag ataataccac cctgaaaaaa     2460

cagttcgaca aaagcccaga aaaatttctg atgtatcagc atgatccgcg taccttcgaa     2520

aaactggaag ttattatgaa acagtatgcc aacgagaaaa atccgctggc caaatatcac     2580

gaagaaaccg gtgaatatct gaccaaatat tccaagaaga acaacggtcc gatcgttaaa     2640

tccctgaaat atatcggtaa taaactgggc agccatctgg atgttaccca tcagtttaaa     2700

agctccacaa agaagctggt taaactgtcc atcaaaccgt atcgctttga tgtgtatctg     2760

accgacaaag gctataaatt cattaccatc agctatctgg acgtgctgaa aaaagacaac     2820

tattattata tcccggaaca gaaatatgat aaactgaaac tgggtaaagc catcgataaa     2880

aacgccaaat ttatcgccag cttctacaaa aacgacctga ttaaactgga tggcgagatc     2940

tataaaatca tcggtgttaa tagcgacacc cgcaatatga ttgagctgga tctgccggat     3000

attcgctata aagaatattg cgaactgaac aacattaaag gcgaaccgcg tatcaaaaag     3060

accatcggca aaaaagtgaa tagcatcgag aaactgacca ccgatgttct gggtaatgtg     3120

tttaccaata cccagtatac caaacctcag ctgctgttca aacgcggtaa t              3171


<210>  14
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding Gib11Spa-1

<400>  14
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggaacgtgt taaactgctg ctgaccgaat atgatctgat taacaaagag      240

cagattccga ccagcaataa cccgtatcag attcgtgtta aaggtctgag cgaaatcctg      300

agcaaagatg aactggcaat tgcactgctg catctggcaa aacgccgtgg cattcataat      360

gttgatgttg cagcagataa agaagaaacc gcaagcgata gcctgagcac caaagatcag      420

attaacaaaa acgccaaatt tctggaaagc cgctatgttt gtgaactgca gaaagaacgt      480

ctggaaaatg aaggtcatgt tcgtggtgtt gaaaatcgct ttctgacgaa agatattgtg      540

cgtgaggcca aaaaaatcat cgatacccag atgcagtatt acccggaaat tgatgaaacc      600

ttcaaagaga aatatatcag cctggttgaa acccgtcgcg aatattttga aggtcctggt      660

cagggtagcc cgtttggttg gaatggtgat ctgaaaaaat ggtacgaaat gctgatgggt      720

cactgtacct attttccgca agaactgcgt agcgttaaat atgcctatag cgcagacctg      780

tttaatgcac tgaatgatct gaacaacctg attattcagc gcgataatag cgagaaactg      840

gaataccatg agaagtatca catcatcgag aacgtgttca agcagaaaaa aaagccgacg      900

ctgaaacaaa tcgcaaaaga gattggcgtt aacccggaag atattaaagg ttatcgtatt      960

accaaaagcg gcacaccgga gtttacatcc tttaaactgt tccacgatct gaaaaaagtg     1020

gtgaaagatc atgccatcct ggatgatatt gatctgctga atcagattgc agaaatcctg     1080

accatctatc aggataaaga tagcattgtt gcagaactgg gtcagctgga atatctgatg     1140

agcgaagccg ataaacagag cattagcgaa ctgaccggtt ataccggtac acatagcctg     1200

tcactgaaat gcatgaacat gattatcgat gaactgtggc atagcagcat gaaccagatg     1260

gaagttttta cctatctgaa tatgcgtccg aaaaagtatg agctgaaagg ttatcagcgt     1320

attccgaccg atatgattga tgatgcaatt ctgagtccgg ttgtgaaacg cacctttatt     1380

cagagcatca acgtgatcaa caaagtgatc gagaaatatg gcatccccga agatatcatt     1440

atcgaactgg cacgtgaaaa taactccgat gatcgcaaaa agttcatcaa caacctgcag     1500

aaaaagaatg aagcaacccg caaacgcatt aacgaaatta ttggtcagac cggtaatcag     1560

aatgccaaac gtattgtgga aaaaatccgt ctgcatgatc agcaagaggg caaatgtctg     1620

tatagcctgg aaagcattcc tctggaagat ctgctgaaca atccgaatca ttatgaagtg     1680

gatcacatta ttccgcgtag cgtgagcttt gataattcct atcataataa agtgctggtg     1740

aaacagagcg aaaactccaa aaaatccaac ctgacaccgt atcagtattt caatagcggc     1800

aaatccaaac tgagctacaa ccagtttaaa cagcatattc tgaacctgag caaaagccag     1860

gatcgcatca gcaagaagaa gaaggagtac ctgctggaag aacgcgatat taacaaattt     1920

gaagtgcaga aagaatttat caaccgcaac ctggttgata cccgttatgc aacccgtgaa     1980

ctgaccaatt atctgaaagc atatttcagc gccaacaaca tgaacgtgaa agtgaaaacg     2040

attaacggca gctttaccga ttatctgcgt aaagtgtgga aattcaaaaa agaacgcaac     2100

cacggctata aacatcatgc cgaagatgcc ctgattattg caaatgcaga tttcctgttt     2160

aaagaaaaca aaaaactgaa agccgtcaac agcgtgctgg aaaaaccgga aattgagaca     2220

aaacagctgg acattcaggt tgatagcgaa gataattaca gcgaaatgtt tatcatcccg     2280

aaacaggtgc aggatatcaa agattttcgc aacttcaaat atagccaccg cgttgacaaa     2340

aaacctaatc gtcagctgat taacgatacc ctgtatagca cccgcaaaaa agataacagc     2400

acctatattg tgcagaccat taaagacatc tacgccaaag ataataccac cctgaaaaaa     2460

cagttcgaca aaagcccaga aaaatttctg atgtatcagc atgatccgcg taccttcgaa     2520

aaactggaag ttattatgaa acagtatgcc aacgagaaaa atccgctggc caaatatcac     2580

gaagaaaccg gtgaatatct gaccaaatat tccaagaaga acaacggtcc gatcgttaaa     2640

tccctgaaat atatcggtaa taaactgggc agccatctgg atgttaccca tcagtttaaa     2700

agctccacaa agaagctggt taagctgtcc attaaaaact atcgcttcga tgtgtatctg     2760

accgagaaag gttataagtt tgtgaccatt gcctacctga atgtgttcaa aaaagacaac     2820

tattactata ttccgaaaga caaataccaa gaacttaaag agaagaagaa aatcaaggac     2880

accgatcagt ttatcgccag cttctataaa aacgatctga tcaagctgaa cggcgacctg     2940

tataaaatca ttggtgtgaa tagtgatgac cgcaacatca ttgagctgga ttattacgac     3000

atcaaataca aggattactg cgagatcaac aacattaaag gtgaaccgcg tatcaaaaag     3060

accattggca aaaaaacgga aagcatcgaa aagtttacca ccgatgttct gggtaatctg     3120

tatctgcata gtaccgaaaa agcaccgcag ctgattttca aacgcggtct g              3171


<210>  15
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Codon-optimized Gib11Spa-1 polynucleotide

<400>  15
atgaaccaga agttcattct cggtctggac attggcatta ctagcgtggg atacggcttg       60

attgactacg agactaagaa catcatcgat gccggcgtcc gcctgttccc ggaagccaac      120

gtggagaaca atgagggccg gaggtcgaag agaggctccc gccgcctgaa gcggcggcga      180

atccaccggc tggagagagt gaagctgctg ctcaccgaat acgacctgat caacaaagaa      240

cagatcccga cctccaacaa cccgtaccag atcagagtga agggtctgtc agaaatcctg      300

tccaaggacg aactggcaat cgccctgctg cacctggcca agcggcgcgg aatccacaac      360

gtggatgtgg ctgccgacaa ggaagaaacc gcttccgact ccctgagcac taaggaccag      420

atcaacaaga acgccaagtt cttggagtcc cgctacgtgt gcgagctgca gaaggaacgg      480

ctggaaaacg aaggtcacgt gcgcggagtg gaaaaccggt tcctgacaaa ggacattgtg      540

cgcgaagcga agaagatcat tgatacccaa atgcagtact accctgaaat cgacgagact      600

ttcaaggaaa agtacatttc cctggtggaa acccggcggg aatacttcga aggccccgga      660

cagggatcgc cgttcggatg gaacggggac ctcaagaagt ggtacgagat gctgatgggg      720

cactgtacct actttccgca agaactgcgc tccgtgaagt acgcgtactc cgcggatctc      780

ttcaacgcgt tgaatgacct gaacaacctg atcattcaga gagacaattc cgaaaagctc      840

gagtaccacg agaagtatca catcatcgag aatgtgttca agcagaagaa gaaaccgacc      900

ctcaagcaaa tcgccaagga gattggcgtc aacccagagg acatcaaggg atatcggatt      960

accaagagcg gcactcccga gtttacctct ttcaagctgt ttcatgatct gaagaaagtc     1020

gtgaaggacc atgccattct cgacgacatt gatctcctga atcagatcgc agagatcctg     1080

actatctacc aagacaagga ctcgattgtg gcagagctgg gtcagctcga atacctgatg     1140

tccgaggccg acaagcagtc catctccgaa ctgacagggt acacggggac tcatagcctg     1200

tcgctgaagt gcatgaacat gatcattgat gaactgtggc acagctccat gaaccaaatg     1260

gaagtgttta cctacctcaa catgcgccct aagaagtacg aactgaaagg ctaccagcgc     1320

atccccaccg acatgatcga cgacgcgatc ttgtcccctg tggtcaagag gaccttcatt     1380

caatccatca acgtgatcaa caaggtcatc gaaaagtacg gaataccaga agatatcatc     1440

attgagctcg ctcgggagaa caactcggat gaccggaaga agttcatcaa caatcttcag     1500

aagaagaacg aagcgactcg gaaacggatc aacgagatca tcggacagac cggaaaccag     1560

aacgccaaac ggattgtcga aaagattaga ctgcacgacc agcaggaagg gaagtgcctg     1620

tactcactcg agtcaatacc gctcgaggac ctgttgaaca accctaacca ctatgaagtg     1680

gaccacatca tccctcggtc cgtgagcttc gacaactcgt accacaacaa agtgctcgtg     1740

aagcagtccg aaaactccaa gaaatccaac ctgaccccgt accaatactt caattcggga     1800

aagtcgaagc tgtcgtacaa ccagttcaaa caacacatac tcaaccttag caaaagccag     1860

gatcgcattt ccaagaagaa gaaggaatac ctcctcgagg aaagggacat caacaagttc     1920

gaagtgcaga aagagttcat caatcgcaac ttggtggata ccagatatgc cacccgggaa     1980

ctcaccaact atctcaaggc ctacttttcc gccaacaaca tgaacgtgaa ggtcaagacc     2040

atcaacgggt ccttcactga ctacctgaga aaggtctgga agttcaagaa ggaacgcaac     2100

cacggataca agcaccacgc tgaggacgct ctgatcatcg ccaatgccga cttcctgttc     2160

aaggaaaaca agaagctgaa agctgtcaac tcagtgctgg aaaagcctga aatcgagact     2220

aagcagctgg atatccaagt ggactctgag gacaactaca gcgagatgtt catcatccct     2280

aaacaagtgc aggatatcaa ggactttcgc aacttcaagt actcacaccg ggtggacaag     2340

aaaccgaata gacagctgat caacgacacg ttgtattcca cccggaagaa ggataactca     2400

acctacattg tgcagactat caaggatatc tacgccaaag ataacactac tctgaagaaa     2460

caattcgaca agtccccaga gaagttcctg atgtaccagc acgacccccg aacctttgag     2520

aagcttgaag tgatcatgaa gcagtacgcc aacgagaaga acccgctggc caagtaccat     2580

gaagaaaccg gagaatacct gaccaagtac agcaagaaga acaacggtcc cattgtcaag     2640

agcctgaagt acatcggcaa caagctggga tcccacctcg acgtgacaca tcagttcaag     2700

tcgtcgacta agaagcttgt gaagctgtca atcaagaact atagattcga cgtgtacttg     2760

accgaaaagg gatacaagtt cgtgaccata gcctatctga acgtgttcaa gaaagataac     2820

tactactaca tccccaagga caagtaccag gagctcaaag aaaagaagaa gatcaaagac     2880

accgaccagt tcattgcctc cttctacaag aacgacctga tcaaactgaa cggcgacctc     2940

tacaagatca ttggagtgaa cagcgatgac aggaacatca ttgagctgga ctactacgac     3000

atcaagtaca aggactactg cgagatcaac aacatcaagg gcgaaccccg gatcaagaaa     3060

actattggaa agaaaaccga gtccattgag aagttcacca ctgacgtgct gggaaacctt     3120

tacctccact ccaccgagaa ggcaccacaa ctgatcttca agcgcggcct g              3171


<210>  16
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding Gib11Spa-2

<400>  16
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggaacgtgt taaactgctg ctgaccgaat atgatctgat taacaaagag      240

cagattccga ccagcaataa cccgtatcag attcgtgtta aaggtctgag cgaaatcctg      300

agcaaagatg aactggcaat tgcactgctg catctggcaa aacgccgtgg cattcataat      360

gttgatgttg cagcagataa agaagaaacc gcaagcgata gcctgagcac caaagatcag      420

attaacaaaa acgccaaatt tctggaaagc cgctatgttt gtgaactgca gaaagaacgt      480

ctggaaaatg aaggtcatgt tcgtggtgtt gaaaatcgct ttctgacgaa agatattgtg      540

cgtgaggcca aaaaaatcat cgatacccag atgcagtatt acccggaaat tgatgaaacc      600

ttcaaagaga aatatatcag cctggttgaa acccgtcgcg aatattttga aggtcctggt      660

cagggtagcc cgtttggttg gaatggtgat ctgaaaaaat ggtacgaaat gctgatgggt      720

cactgtacct attttccgca agaactgcgt agcgttaaat atgcctatag cgcagacctg      780

tttaatgcac tgaatgatct gaacaacctg attattcagc gcgataatag cgagaaactg      840

gaataccatg agaagtatca catcatcgag aacgtgttca agcagaaaaa aaagccgacg      900

ctgaaacaaa tcgcaaaaga gattggcgtt aacccggaag atattaaagg ttatcgtatt      960

accaaaagcg gcacaccgga gtttacatcc tttaaactgt tccacgatct gaaaaaagtg     1020

gtgaaagatc atgccatcct ggatgatatt gatctgctga atcagattgc agaaatcctg     1080

accatctatc aggataaaga tagcattgtt gcagaactgg gtcagctgga atatctgatg     1140

agcgaagccg ataaacagag cattagcgaa ctgaccggtt ataccggtac acatagcctg     1200

tcactgaaat gcatgaacat gattatcgat gaactgtggc atagcagcat gaaccagatg     1260

gaagttttta cctatctgaa tatgcgtccg aaaaagtatg agctgaaagg ttatcagcgt     1320

attccgaccg atatgattga tgatgcaatt ctgagtccgg ttgtgaaacg cacctttatt     1380

cagagcatca acgtgatcaa caaagtgatc gagaaatatg gcatccccga agatatcatt     1440

atcgaactgg cacgtgaaaa taactccgat gatcgcaaaa agttcatcaa caacctgcag     1500

aaaaagaatg aagcaacccg caaacgcatt aacgaaatta ttggtcagac cggtaatcag     1560

aatgccaaac gtattgtgga aaaaatccgt ctgcatgatc agcaagaggg caaatgtctg     1620

tatagcctgg aaagcattcc tctggaagat ctgctgaaca atccgaatca ttatgaagtg     1680

gatcacatta ttccgcgtag cgtgagcttt gataattcct atcataataa agtgctggtg     1740

aaacagagcg aaaactccaa aaaatccaac ctgacaccgt atcagtattt caatagcggc     1800

aaatccaaac tgagctacaa ccagtttaaa cagcatattc tgaacctgag caaaagccag     1860

gatcgcatca gcaagaagaa gaaggagtac ctgctggaag aacgcgatat taacaaattt     1920

gaagtgcaga aagaatttat caaccgcaac ctggttgata cccgttatgc aacccgtgaa     1980

ctgaccaatt atctgaaagc atatttcagc gccaacaaca tgaacgtgaa agtgaaaacg     2040

attaacggca gctttaccga ttatctgcgt aaagtgtgga aattcaaaaa agaacgcaac     2100

cacggctata aacatcatgc cgaagatgcc ctgattattg caaatgcaga tttcctgttt     2160

aaagaaaaca aaaaactgaa agccgtcaac agcgtgctgg aaaaaccgga aattgagaca     2220

aaacagctgg acattcaggt tgatagcgaa gataattaca gcgaaatgtt tatcatcccg     2280

aaacaggtgc aggatatcaa agattttcgc aacttcaaat tcagccaccg cgttgataaa     2340

aaaccgaatc gtcagctgat taacgatacc ctgtatagca cccgtatgaa agatgagcat     2400

gattatattg tgcagaccat cacggatatc tatggcaaag ataataccaa cctgaaaaaa     2460

cagttcaaca aaaacccgga aaaatttctg atgtatcaga acgatccgaa aacctttgag     2520

aaactgagca tcatcatgaa acagtacagc gacgaaaaaa acccgctggc caaatattac     2580

gaagaaaccg gtgaatatct gaccaaatat agcaagaaaa acaacggtcc gatcgtgaaa     2640

aagatcaaac tgctgggtaa taaagtgggc aatcatctgg atgtgaccaa caaatatgaa     2700

aactccacga agaagctggt taagctgtcc attaaaaact atcgcttcga tgtgtatctg     2760

accgagaaag gttataagtt tgtgaccatt gcctacctga atgtgttcaa aaaagacaac     2820

tattactata ttccgaaaga caaataccaa gaacttaaag agaagaagaa aatcaaggac     2880

accgatcagt ttatcgccag cttctataaa aacgatctga tcaagctgaa cggcgacctg     2940

tataaaatca ttggtgtgaa tagtgatgac cgcaacatca ttgagctgga ttattacgac     3000

atcaaataca aggattactg cgagatcaac aacattaaag gtgaaccgcg tatcaaaaag     3060

accattggca aaaaaacgga aagcatcgaa aagtttacca ccgatgttct gggtaatctg     3120

tatctgcata gtaccgaaaa agcaccgcag ctgattttca aacgcggtct g              3171


<210>  17
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding Gib11Spa-3

<400>  17
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggaacgtgt taaactgctg ctgaccgaat atgatctgat taacaaagag      240

cagattccga ccagcaataa cccgtatcag attcgtgtta aaggtctgag cgaaatcctg      300

agcaaagatg aactggcaat tgcactgctg catctggcaa aacgccgtgg cattcataat      360

gttgatgttg cagcagataa agaagaaacc gcaagcgata gcctgagcac caaagatcag      420

attaacaaaa acgccaaatt tctggaaagc cgctatgttt gtgaactgca gaaagaacgt      480

ctggaaaatg aaggtcatgt tcgtggtgtt gaaaatcgct ttctgacgaa agatattgtg      540

cgtgaggcca aaaaaatcat cgatacccag atgcagtatt acccggaaat tgatgaaacc      600

ttcaaagaga aatatatcag cctggttgaa acccgtcgcg aatattttga aggtcctggt      660

cagggtagcc cgtttggttg gaatggtgat ctgaaaaaat ggtacgaaat gctgatgggt      720

cactgtacct attttccgca agaactgcgt agcgttaaat atgcctatag cgcagacctg      780

tttaatgcac tgaatgatct gaacaacctg attattcagc gcgataatag cgagaaactg      840

gaataccatg agaagtatca catcatcgag aacgtgttca agcagaaaaa aaagccgacg      900

ctgaaacaaa tcgcaaaaga gattggcgtt aacccggaag atattaaagg ttatcgtatt      960

accaaaagcg gcacaccgga gtttacatcc tttaaactgt tccacgatct gaaaaaagtg     1020

gtgaaagatc atgccatcct ggatgatatt gatctgctga atcagattgc agaaatcctg     1080

accatctatc aggataaaga tagcattgtt gcagaactgg gtcagctgga atatctgatg     1140

agcgaagccg ataaacagag cattagcgaa ctgaccggtt ataccggtac acatagcctg     1200

tcactgaaat gcatgaacat gattatcgat gaactgtggc atagcagcat gaaccagatg     1260

gaagttttta cctatctgaa tatgcgtccg aaaaagtatg agctgaaagg ttatcagcgt     1320

attccgaccg atatgattga tgatgcaatt ctgagtccgg ttgtgaaacg cacctttatt     1380

cagagcatca acgtgatcaa caaagtgatc gagaaatatg gcatccccga agatatcatt     1440

atcgaactgg cacgtgaaaa taactccgat gatcgcaaaa agttcatcaa caacctgcag     1500

aaaaagaatg aagcaacccg caaacgcatt aacgaaatta ttggtcagac cggtaatcag     1560

aatgccaaac gtattgtgga aaaaatccgt ctgcatgatc agcaagaggg caaatgtctg     1620

tatagcctgg aaagcattcc tctggaagat ctgctgaaca atccgaatca ttatgaagtg     1680

gatcacatta ttccgcgtag cgtgagcttt gataattcct atcataataa agtgctggtg     1740

aaacagagcg aaaactccaa aaaatccaac ctgacaccgt atcagtattt caatagcggc     1800

aaatccaaac tgagctacaa ccagtttaaa cagcatattc tgaacctgag caaaagccag     1860

gatcgcatca gcaagaagaa gaaggagtac ctgctggaag aacgcgatat caacaaattt     1920

gaagtccaga aagagtttat caaccgcaat ctggttgata cccgttatgc aacccgtgaa     1980

ctgaccagct atctgaaagc atatttcagc gccaataaca tggacgtgaa agtgaaaaca     2040

attaacggca gctttaccaa ccatctgcgt aaagtttggc gctttgataa atatcgcaac     2100

cacggctata aacatcatgc cgaagatgca ctgattattg ccaatgcaga tttcctgttc     2160

aaagaaaaca aaaaactgca gaacaccaac aagatcctgg aaaaaccgac cattgaaaac     2220

aacaccaaaa aagtgaccgt cgagaaagaa gaggattaca acaacgtttt tgaaaccccg     2280

aaactggtcg aggatattaa acagtatcgc gactataaat tcagccaccg cgttgataaa     2340

aaaccgaatc gtcagctgat taacgatacc ctgtatagca cccgtatgaa agatgagcat     2400

gattatattg tgcagaccat cacggatatc tatggcaaag ataataccaa cctgaaaaaa     2460

cagttcaaca aaaacccgga aaaatttctg atgtatcaga acgatccgaa aacctttgag     2520

aaactgagca tcatcatgaa acagtacagc gacgaaaaaa acccgctggc caaatattac     2580

gaagaaaccg gtgaatatct gaccaaatat agcaagaaaa acaacggtcc gatcgtgaaa     2640

aagatcaaac tgctgggtaa taaagtgggc aatcatctgg atgtgaccaa caaatatgaa     2700

aactccacga agaagctggt taagctgtcc attaaaaact atcgcttcga tgtgtatctg     2760

accgagaaag gttataagtt tgtgaccatt gcctacctga atgtgttcaa aaaagacaac     2820

tattactata ttccgaaaga caaataccaa gaacttaaag agaagaagaa aatcaaggac     2880

accgatcagt ttatcgccag cttctataaa aacgatctga tcaagctgaa cggcgacctg     2940

tataaaatca ttggtgtgaa tagtgatgac cgcaacatca ttgagctgga ttattacgac     3000

atcaaataca aggattactg cgagatcaac aacattaaag gtgaaccgcg tatcaaaaag     3060

accattggca aaaaaacgga aagcatcgaa aagtttacca ccgatgttct gggtaatctg     3120

tatctgcata gtaccgaaaa agcaccgcag ctgattttca aacgcggtct g              3171


<210>  18
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Codon-optimized Gib11Spa-3 polynucleotide

<400>  18
atgaaccaga agttcattct cggtctggac attggcatta ctagcgtggg atacggcttg       60

attgactacg agactaagaa catcatcgat gccggcgtcc gcctgttccc ggaagccaac      120

gtggagaaca atgagggccg gaggtcgaag agaggctccc gccgcctgaa gcggcggcga      180

atccaccggc tggagagagt gaagctgctg ctcaccgaat acgacctgat caacaaagaa      240

cagatcccga cctccaacaa cccgtaccag atcagagtga agggtctgtc agaaatcctg      300

tccaaggacg aactggcaat cgccctgctg cacctggcca agcggcgcgg aatccacaac      360

gtggatgtgg ctgccgacaa ggaagaaacc gcttccgact ccctgagcac taaggaccag      420

atcaacaaga acgccaagtt cttggagtcc cgctacgtgt gcgagctgca gaaggaacgg      480

ctggaaaacg aaggtcacgt gcgcggagtg gaaaaccggt tcctgacaaa ggacattgtg      540

cgcgaagcga agaagatcat tgatacccaa atgcagtact accctgaaat cgacgagact      600

ttcaaggaaa agtacatttc cctggtggaa acccggcggg aatacttcga aggccccgga      660

cagggatcgc cgttcggatg gaacggggac ctcaagaagt ggtacgagat gctgatgggg      720

cactgtacct actttccgca agaactgcgc tccgtgaagt acgcgtactc cgcggatctc      780

ttcaacgcgt tgaatgacct gaacaacctg atcattcaga gagacaattc cgaaaagctc      840

gagtaccacg agaagtatca catcatcgag aatgtgttca agcagaagaa gaaaccgacc      900

ctcaagcaaa tcgccaagga gattggcgtc aacccagagg acatcaaggg atatcggatt      960

accaagagcg gcactcccga gtttacctct ttcaagctgt ttcatgatct gaagaaagtc     1020

gtgaaggacc atgccattct cgacgacatt gatctcctga atcagatcgc agagatcctg     1080

actatctacc aagacaagga ctcgattgtg gcagagctgg gtcagctcga atacctgatg     1140

tccgaggccg acaagcagtc catctccgaa ctgacagggt acacggggac tcatagcctg     1200

tcgctgaagt gcatgaacat gatcattgat gaactgtggc acagctccat gaaccaaatg     1260

gaagtgttta cctacctcaa catgcgccct aagaagtacg aactgaaagg ctaccagcgc     1320

atccccaccg acatgatcga cgacgcgatc ttgtcccctg tggtcaagag gaccttcatt     1380

caatccatca acgtgatcaa caaggtcatc gaaaagtacg gtattccaga agatatcatc     1440

attgagctcg ctcgggagaa caactcggat gaccggaaga agttcatcaa caatcttcag     1500

aagaagaacg aagcgactcg gaaacggatc aacgagatca tcggacagac cggaaaccag     1560

aacgccaaac ggattgtcga aaagattaga ctgcacgacc agcaggaagg gaagtgcctg     1620

tactcactcg agtcaatacc gctcgaggac ctgttgaaca accctaacca ctatgaagtg     1680

gaccacatca tccctcggtc cgtgagcttc gacaactcgt accacaacaa agtgctcgtg     1740

aagcagtccg aaaactccaa gaaatccaac ctgaccccgt accaatactt caattcggga     1800

aagtcgaagc tgtcgtacaa ccagttcaaa caacacatac tcaaccttag caaaagccag     1860

gatcgcattt ccaagaagaa gaaggaatac ctcctcgagg aaagggacat caacaagttc     1920

gaagtgcaga aagagttcat caatcgcaac ttggtggata ccagatatgc cacccgggaa     1980

ctcaccagct atctcaaggc ctacttttcc gccaacaaca tggacgtgaa ggtcaagacc     2040

atcaacgggt ccttcactaa ccatctgaga aaggtctggc ggtttgacaa gtaccgcaac     2100

cacggataca agcaccacgc tgaagacgct ctgatcatcg ccaatgccga cttcctgttc     2160

aaggaaaaca agaagctgca gaacacgaac aagattctgg aaaagcctac cattgagaac     2220

aacactaaga aggtcaccgt ggagaaggaa gaggactaca acaacgtgtt cgaaactcct     2280

aaactggtgg aggatatcaa gcaataccgc gactacaagt tctcacaccg ggtggacaag     2340

aaaccgaata gacagctgat caacgacacg ttgtattcca cccggatgaa ggatgagcat     2400

gactacattg tgcagactat caccgatatc tacggaaaag ataacactaa cctgaagaaa     2460

caattcaaca agaacccaga gaagttcctg atgtaccaga acgaccccaa gacctttgag     2520

aagctttcca tcatcatgaa gcagtactcc gacgagaaga acccgctggc caagtactac     2580

gaagaaaccg gagaatacct gaccaagtac agcaagaaga acaacggtcc cattgtcaag     2640

aagatcaagc tgctcggcaa caaggtcgga aaccacctcg acgtgacaaa caagtacgag     2700

aactcgacta agaagcttgt gaagctgtca atcaagaact atagattcga cgtgtacttg     2760

accgaaaagg gatacaagtt cgtgaccata gcctatctga acgtgttcaa gaaagataac     2820

tactactaca tccccaagga caagtaccag gagctcaaag aaaagaagaa gatcaaagac     2880

accgaccagt tcattgcctc cttctacaag aacgacctga tcaaactgaa cggcgacctc     2940

tacaagatca ttggagtgaa cagcgatgac aggaacatca ttgagctgga ctactacgac     3000

atcaagtaca aggactactg cgagatcaac aacatcaagg gcgaaccccg gatcaagaaa     3060

actattggaa agaaaaccga gtccattgag aagttcacca ctgacgtgct gggaaacctt     3120

tacctccact ccaccgagaa ggcaccacaa ctgatcttca agcgcggcct g              3171


<210>  19
<211>  3166
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding P2H12

<400>  19
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggaacgtgt taaaaaactg ctggaagatt ataacctgct ggatcagagc      240

cagattccgc agagcaccaa tccgtatgca attcgtgtta aaggtctgag cgaagcactg      300

agcaaagatg aactggttat tgcactgctg catattgcaa aacgccgtgg cattcataat      360

atcaatgtta gcagcgaaga tgaggatgca agcaatgaac tgagcaccaa agaacaaatt      420

aaccgcaata ataagctgct gaaggacaaa tatgtttgcg aagttcagct gcagcgtctg      480

aaagaaggtc agattcgcgg agaaaaaaat cgctttaaaa ccaccgatat cctgaaagaa      540

attgatcagc tgcttaaagt gcagaaggat tatcataacc tggacatcga tttcatcaac      600

cagtacaaag aaatcgttga aacccgtcgc gaatattttg aaggtccggg taaaggtagc      660

ccgtatggtt gggaaggtga tccgaaagca tggtatgaaa ccctgatggg tcattgtacc      720

tattttccgg atgaactgcg tagcgttaaa tatgcctata gcgcagacct gtttaatgca      780

ctgaatgatc tgaataacct ggtgattcag cgtgatggtc tgagcaaact ggaatatcat      840

gagaaatatc acatcatcga aaacgtgttc aaacagaaga agaaaccgac cctgaaacaa      900

atcgccaacg aaattaatgt gaacccggaa gatattaaag gctaccgtat taccaaaagc      960

ggcaaaccgg aatttacatc ctttaaactg ttccacgatc tgaaaaaagt ggtgaaagat     1020

catgccatcc tggatgatat tgatctgctg aatcagattg cagaaatcct gaccatctat     1080

caggataaag atagcattgt tgcagaactg ggtcagctgg aatatctgat gagcgaagcc     1140

gataaacaga gcattagcga actgaccggt tataccggta cacatagcct gtcactgaaa     1200

tgcatgaaca tgattatcga tgaactgtgg catagcagca tgaaccagat ggaagttttt     1260

acctatctga atatgcgtcc gaaaaagtat gagctgaaag gttatcagcg tattccgacc     1320

gatatgattg atgatgcaat tctgagtccg gttgtgaaac gcacctttat tcagagcatc     1380

aacgtgatca acaaagtgat cgagaaatat ggcatccccg aagatatcat tatcgaactg     1440

gcacgtgaaa ataactccga tgatcgcaaa aagttcatca acaacctgca gaaaaagaat     1500

gaagcaaccc gcaaacgcat taacgaaatt attggtcaga ccggtaatca gaatgccaaa     1560

cgtattgtgg aaaaaatccg tctgcatgat cagcaagagg gtaaatgtct gtatagcctg     1620

gaaagcattc ctctggaaga tctgctgaac aatccgaatc attatgaagt ggatcacatt     1680

attccgcgta gcgtgagctt tgataattcc tatcataata aagtgctggt gaaacagagc     1740

gaaaactcca aaaaatccaa cctgacaccg tatcagtatt tcaatagcgg caaatccaaa     1800

ctgagctaca accagtttaa acagcatatt ctgaacctga gcaaaagcca ggatcgcatc     1860

agcaagaaga agaaggagta cctgctggaa gaacgcgata ttaacaaatt tgaagtgcag     1920

aaagaattta tcaaccgcaa cctggttgat acccgttatg caacccgtga actgaccaat     1980

tatctgaaag catatttcag cgccaacaac atgaacgtga aagtgaaaac gattaacggc     2040

agctttaccg attatctgcg taaagtgtgg aaattcaaaa aagaacgcaa ccacggctat     2100

aaacatcatg ccgaagatgc cctgattatt gcaaatgcag atttcctgtt taaagaaaac     2160

aaaaaactga aagccgtcaa cagcgtgctg gaaaaaccgg aaattgagac aaaacagctg     2220

gacattcagg ttgatagcga agataattac agcgaaatgt ttatcatccc gaaacaggtg     2280

caggatatca aagattttcg caacttcaaa tatagccacc gcgttgacaa aaaacctaat     2340

cgtcagctga ttaacgatac cctgtatagc acccgcaaaa aagataacag cacctatatt     2400

gtgcagacca ttaaagacat ctacgccaaa gataatacca ccctgaaaaa acagttcgac     2460

aaaagcccag aaaaatttct gatgtatcag catgatccgc gtaccttcga aaaactggaa     2520

gttattatga aacagtatgc caacgagaaa aatccgctgg ccaaatatca cgaagaaacc     2580

ggtgaatatc tgaccaaata ttccaagaag aacaacggtc cgatcgttaa atccctgaaa     2640

tatatcggta ataaactggg cagccatctg gatgttaccc atcagtttaa aagctccaca     2700

aagaagctgg ttaaactgtc catcaaaccg tatcgctttg atgtgtatct gaccgacaaa     2760

ggctataaat tcattaccat cagctatctg gacgtgctga aaaaagacaa ctattattat     2820

atcccggaac agaaatatga taaactgaaa ctgggtaaag ccatcgataa aaacgccaaa     2880

tttatcgcca gcttctacaa aaacgacctg attaaactgg atggcgagat ctataaaatc     2940

atcggtgtta atagcgacac ccgcaatatg attgagctgg atctgccgga tattcgctat     3000

aaagaatatt gcgaactgaa caacattaaa ggcgaaccgc gtatcaaaaa gaccatcggc     3060

aaaaaagtga atagcatcga gaaactgacc accgatgttc tgggtaatgt gtttaccaat     3120

acccagtata ccaaacctca gctgctgttc aaacgcggta atggtg                    3166


<210>  20
<211>  3162
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Codon-optimized P2H12 polynucleotide

<400>  20
atgaaccaaa agttcattct ggggctcgat atcggcatca cctccgtggg atatggtctg       60

atcgactacg agactaagaa catcatcgac gctggagtgc gactgttccc ggaagcgaac      120

gtggagaaca acgaaggccg cagatccaag cgcgggtcca gaaggctcaa gaggcggagg      180

atccatagac tcgagagagt gaagaagctc cttgaagatt acaatctgtt ggaccagtca      240

cagattcccc aaagcaccaa cccgtacgcc atcagagtga agggcctgtc agaagcactg      300

tcgaaagatg aactggtcat tgccctgctg catattgcca aacggcgcgg aatccataac      360

atcaacgtgt cgagcgaaga tgaggacgcg tccaacgaac tgtcaaccaa ggaacagatc      420

aaccggaaca acaaactgct gaaggacaaa tacgtctgcg aggtgcagct tcaacggctg      480

aaagagggac agatcagggg agagaaaaac cggttcaaga ccaccgacat ccttaaggag      540

atcgaccaac tcctgaaagt gcagaaggac tatcacaacc tcgacattga ttttatcaac      600

cagtacaagg agattgtgga aactcggagg gagtacttcg agggacctgg aaagggatcc      660

ccttatggct gggaagggga ccccaaggct tggtacgaaa ccctgatggg ccattgcact      720

tactttccgg atgaactccg gtccgtgaag tacgcttact ctgccgacct gttcaatgca      780

ctcaacgacc ttaacaactt ggtgatccaa cgcgatggtc tttccaagtt ggagtaccac      840

gaaaagtacc acatcatcga gaacgtgttc aagcagaaaa agaagccaac tctgaagcag      900

attgccaacg aaattaacgt gaaccccgag gatatcaagg gataccggat taccaagtcc      960

ggcaaaccag agttcacctc attcaagctg tttcacgatc tgaagaaggt cgtgaaggac     1020

cacgccatcc tggatgacat tgatcttctg aaccagattg ctgagatcct gaccatctac     1080

caggacaagg actcgattgt ggccgaactg ggacagctcg agtacctgat gtccgaagcc     1140

gataagcagt ccatcagcga actcaccggt tacaccggta cccactcctt gtcccttaag     1200

tgcatgaaca tgatcattga cgaactgtgg cactccagca tgaaccagat ggaggtgttc     1260

acctacttga acatgcgccc gaagaagtac gagctgaagg gctaccagcg catacccacg     1320

gacatgatcg acgacgccat cctctcaccg gtggtcaagc gcaccttcat tcaatctatc     1380

aacgtgatca acaaggtcat cgagaagtac ggcattcctg aggatatcat catcgagctg     1440

gctcgggaga acaactcaga cgataggaag aagttcatta acaacctcca gaaaaagaac     1500

gaggccactc gcaagcggat taatgagatc atcggtcaga ccgggaacca gaacgccaag     1560

cggatcgtgg aaaagattcg gctccacgac caacaggagg gaaagtgtct gtactcgctg     1620

gagtccattc ccctggagga cctcctgaac aacccaaacc actacgaggt cgatcacata     1680

atcccccgca gcgtgtcatt cgacaactcc taccataaca aggtcctcgt gaagcagtcg     1740

gagaatagca agaagtcgaa cctgactccg taccagtact tcaactccgg caaatccaag     1800

ctgtcctaca atcagttcaa acagcacatt ctcaacctgt ccaagagcca ggacaggatt     1860

tcgaagaaga agaaggaata ccttctcgag gaacgggata tcaataagtt cgaggtgcag     1920

aaggagttta tcaatagaaa cctggtggac actcgctatg ccacccgcga actgaccaac     1980

tacctgaagg cgtacttctc cgccaacaac atgaacgtga aggtcaaaac tattaacggc     2040

agcttcaccg actatctgcg caaggtctgg aagttcaaga aggaacgcaa ccacggttac     2100

aagcaccacg cggaagatgc gctgattatc gccaacgctg acttcctgtt caaggaaaac     2160

aagaagctca aggccgtgaa ctcagtgctc gagaagcctg aaatcgagac taagcagctg     2220

gacatccagg tcgattcgga agataactac tccgaaatgt tcatcatccc taagcaagtg     2280

caggacatca aggacttcag gaatttcaag tacagccatc gcgtggacaa gaagccaaac     2340

agacagctga tcaacgatac actgtattcc acccggaaga aggacaactc cacctacatc     2400

gtccaaacca ttaaggacat ctacgcaaag gacaacacca cgcttaagaa gcagttcgac     2460

aagagccccg aaaagttcct catgtaccag cacgacccca gaaccttcga gaagcttgaa     2520

gtgatcatga agcagtacgc caacgaaaag aacccactgg ctaagtacca cgaggaaacc     2580

ggcgaatacc tgaccaagta ctccaaaaag aacaacggac cgatcgtcaa gtccctgaag     2640

tacattggga acaagctcgg ctcgcacctc gatgtgaccc accagttcaa gtcctcgacc     2700

aaaaagctcg tgaagctgtc catcaagccg taccggttcg acgtgtacct gactgacaag     2760

ggatataagt tcatcaccat ttcctacctc gacgtgttga agaaggataa ctactactac     2820

attccggaac agaagtacga caagctcaag ctcggaaagg ccatcgacaa aaatgcgaag     2880

ttcatcgcga gcttctacaa gaatgacttg atcaagctgg atggcgaaat ctacaagatc     2940

atcggggtca actccgatac ccgcaacatg attgagctgg atctgcccga cattcggtac     3000

aaggaatact gcgagctgaa caacatcaag ggagaaccgc ggatcaagaa aaccatcgga     3060

aagaaagtga acagcatcga gaaactgact actgacgtcc tgggaaacgt gttcaccaac     3120

acacaataca ccaaacccca gctgctgttt aagcgcggga ac                        3162


<210>  21
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding E2

<400>  21
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggatcgtgt taaacatctg ctggcagaat atgatctgct ggatctgacc      240

aatattccga aaagcaccaa tccgtatcag acccgtgtta aaggtctgaa tgaaaagctg      300

agcaaagatg aactggttat tgcactgctg catattgcaa aacgccgtgg cattcataac      360

gttgatgttg cagcagataa agaagaaacc gcaagcgata gcctgagcac caaagatcag      420

attaacaaaa acgccaaatt tctggaaagc cgctatgttt gtgaactgca gaaagaacgt      480

ctggaaaatg aaggtcatgt tcgtggtgtt gaaaatcgct ttctgacgaa agatattgtg      540

cgtgaggcca aaaaaatcat cgatacccag atgcagtatt acccggaaat tgatgaaacc      600

ttcaaagaga aatatatcag cctggttgaa acccgtcgcg aatattttga aggtccgggt      660

aaaggtagcc cgtttggttg ggaaggtaat atcaagaaat ggtttgagca gatgatgggc      720

cactgtacct attttccaga agaactgcgt agcgtcaaat atagctattc agccgaactg      780

tttaacgccc tgaatgatct gaataatctg gtgattaccc gtgatgaaga tgccaaactg      840

aattatggtg agaaattcca gatcatcgaa aacgtgttca aacagaagaa aacaccgaac      900

ctgaaacaaa tcgccattga aattggtgtg catgaaaccg aaatcaaagg ttatcgtgtg      960

aacaaaagcg gtacaccgga atttaccgaa tttaaactgt atcatgacct gaaaagcatc     1020

gtgttcgata aaagcattct ggaaaatgaa gccatcctgg atcagattgc agaaattctg     1080

accatctatc aggatgagca gagcattaaa gaggaactga ataaactgcc ggaaatactg     1140

aacgaacagg ataaagcaga aatcgccaaa ctgattggtt ataatggcac ccatcgtctg     1200

agcctgaaat gtattcacct gattaatgaa gaactgtggc agaccagccg taatcagatg     1260

gaaattttca actacctgaa catcaaaccg aacaaagtgg atctgagtga gcagaacaaa     1320

atcccgaaag atatggtgaa cgactttatt ctgagtccgg ttgtgaaacg cacctttatt     1380

cagagcatca acgtgatcaa caaagtgatc gagaaatatg gcatccccga agatatcatt     1440

atcgaactgg cacgtgaaaa taactccgat gatcgcaaaa agttcatcaa caacctgcag     1500

aaaaagaatg aagcaacccg caaacgcatt aacgaaatta ttggtcagac cggtaatcag     1560

aatgccaaac gtattgtgga aaaaatccgt ctgcatgatc agcaagaggg taaatgtctg     1620

tatagcctga aagatatccc gctggaagat ctgctgcgca atccgaacaa ttatgatatc     1680

gaccatatta ttccgcgaag cgtgagcttt gatgatagca tgcataacaa agttctggtt     1740

cgtcgcgaac agaatgccaa aaagaataat cagaccccgt atcagtatct gaccagtggt     1800

tatgcagata tcaaatacag cgtgtttaag cagcatgttc tgaatctggc cgaaaataaa     1860

gatcgcatga ccaaaaaaaa gcgcgagtat ctgctggaag aacgcgacat taacaaattt     1920

gaagtgcaga aagaatttat caaccgcaac ctggttgata cccgttatgc aacccgtgaa     1980

ctgaccaatt atctgaaagc atatttcagc gccaacaaca tgaacgtgaa agtgaaaacg     2040

attaacggca gctttaccga ttatctgcgt aaagtgtgga aattcaaaaa agaacgcaac     2100

cacggctata aacatcatgc cgaagatgcc ctgattattg caaatgcaga tttcctgttt     2160

aaagaaaaca aaaaactgaa agccgtcaac agcgtgctgg aaaaaccgga aattgagaca     2220

aaacagctgg acattcaggt tgatagcgaa gataattaca gcgaaatgtt tatcatcccg     2280

aaacaggtgc aggatatcaa agattttcgc aacttcaaat atagccaccg cgttgacaaa     2340

aaacctaatc gtcagctgat taacgatacc ctgtatagca cccgcaaaaa agataacagc     2400

acctatattg tgcagaccat taaagacatc tacgccaaag ataataccac cctgaaaaaa     2460

cagttcgaca aaagcccaga aaaatttctg atgtatcagc atgatccgcg taccttcgaa     2520

aaactggaag ttattatgaa acagtatgcc aacgagaaaa atccgctggc caaatatcac     2580

gaagaaaccg gtgaatatct gaccaaatat tccaagaaga acaacggtcc gatcgttaaa     2640

tccctgaaat atatcggtaa taaactgggc agccatctgg atgttaccca tcagtttaaa     2700

agctccacaa agaagctggt taaactgtcc atcaaaccgt atcgctttga tgtgtatctg     2760

accgacaaag gctataaatt cattaccatc agctatctgg acgtgctgaa aaaagacaac     2820

tattattata tcccggaaca gaaatatgat aaactgaaac tgggtaaagc catcgataaa     2880

aacgccaaat ttatcgccag cttctacaaa aacgacctga ttaaactgga tggcgagatc     2940

tataaaatca tcggtgttaa tagcgacacc cgcaatatga ttgagctgga tctgccggat     3000

attcgctata aagaatattg cgaactgaac aacattaaag gcgaaccgcg tatcaaaaag     3060

accatcggca aaaaagtgaa tagcatcgag aaactgacca ccgatgttct gggtaatgtg     3120

tttaccaata cccagtatac caaacctcag ctgctgttca aacgcggtaa t              3171


<210>  22
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Codon-optimized E2 polynucleotide

<400>  22
atgaaccaaa agttcattct ggggctcgat atcggcatca cctccgtggg atatggtctg       60

atcgactacg agactaagaa catcatcgac gctggagtgc gactgttccc ggaagcgaac      120

gtggagaaca acgaaggccg cagatccaag cgcgggtcca gaaggctcaa gaggcggagg      180

atccatagac tcgacagagt gaagcacctc cttgccgaat acgatctgtt ggaccttacc      240

aacattccca agagcaccaa cccgtaccaa accagagtga agggcctgaa cgaaaagctg      300

tcgaaagatg aactggtcat tgccctgctg catattgcca aacggcgcgg aatccataac      360

gtggacgtgg ccgctgacaa ggaagagact gcgtccgact cgctgtcaac caaggaccag      420

atcaacaaga acgccaaatt cctggaaagc cgctacgtct gcgagcttca aaaagaacgg      480

ctggagaacg agggacacgt caggggagtg gagaaccggt tcctgaccaa ggacatcgtg      540

cgggaagcca agaagatcat cgacacccaa atgcagtatt atccggaaat tgatgaaact      600

tttaaggaga agtacatttc cctggtggaa actcggaggg agtacttcga gggacctgga      660

aagggatccc ctttcggctg ggaagggaac attaagaagt ggtttgaaca gatgatgggc      720

cattgcactt actttccgga agaactccgg tccgtgaagt actcatactc tgccgagctg      780

ttcaatgcac tcaacgacct taacaacttg gtgatcaccc gcgatgaaga tgccaagttg      840

aactacggag aaaagttcca gatcatcgag aacgtgttca agcagaaaaa gaccccaaat      900

ctgaagcaga ttgccatcga aattggcgtg cacgagactg agatcaaggg ataccgggtc      960

aacaagtccg gcacgccaga gttcaccgag ttcaagctgt accacgatct gaagtcgatc     1020

gtgtttgaca agtccatcct ggaaaacgaa gccattctgg accagattgc tgagatcctg     1080

accatctacc aggacgagca atcgattaag gaagaactga acaagctccc cgagattctg     1140

aacgaacagg ataaggccga gatcgcgaag ctcattggtt acaatggtac ccaccgcttg     1200

tcccttaagt gcatccatct gatcaatgag gaactgtggc agaccagccg gaaccagatg     1260

gagatcttca attacttgaa catcaagccg aacaaggtgg acctgtccga acagaacaag     1320

atacccaagg acatggtcaa cgactttatc ctctcaccgg tggtcaagcg caccttcatt     1380

caatctatca acgtgatcaa caaggtcatc gagaagtacg gcattcctga ggatatcatc     1440

atcgagctgg ctcgggagaa caactcagac gataggaaga agttcattaa caacctccag     1500

aaaaagaacg aggccactcg caagcggatt aatgagatca tcggtcagac cgggaaccag     1560

aacgccaagc ggatcgtgga aaagattcgg ctccacgacc aacaggaggg aaagtgtctg     1620

tactcgctga aggacattcc cctggaggac ctcctgagga acccaaacaa ctacgacatc     1680

gatcacataa tcccccgcag cgtgtcattc gacgattcca tgcataacaa ggtcctcgtg     1740

cggagagagc agaatgccaa gaagaacaac cagactccgt accagtacct gacgtccggc     1800

tacgcagaca tcaagtactc agtgttcaaa cagcacgtgc tcaacctggc cgagaacaag     1860

gacaggatga ccaagaagaa gcgcgaatac cttctcgagg aacgggatat caataagttc     1920

gaggtgcaga aggagtttat caatagaaac ctggtggaca ctcgctatgc cacccgcgaa     1980

ctgaccaact acctgaaggc gtacttctcc gccaacaaca tgaacgtgaa ggtcaaaact     2040

attaacggca gcttcaccga ctatctgcgc aaggtctgga agttcaagaa ggaacgcaac     2100

cacggttaca agcaccacgc ggaagatgcg ctgattatcg ccaacgctga cttcctgttc     2160

aaggaaaaca agaagctcaa ggccgtgaac tcagtgctcg agaagcctga aatcgagact     2220

aagcagctgg acatccaggt cgattcggaa gataactact ccgaaatgtt catcatccct     2280

aagcaagtgc aggacatcaa ggacttcagg aatttcaagt acagccatcg cgtggacaag     2340

aagccaaaca gacagctgat caacgataca ctgtattcca cccggaagaa ggacaactcc     2400

acctacatcg tccaaaccat taaggacatc tacgcaaagg acaacaccac gcttaagaag     2460

cagttcgaca agagccccga aaagttcctc atgtaccagc acgaccccag aaccttcgag     2520

aagcttgaag tgatcatgaa gcagtacgcc aacgaaaaga acccactggc taagtaccac     2580

gaggaaaccg gcgaatacct gaccaagtac tccaaaaaga acaacggacc gatcgtcaag     2640

tccctgaagt acattgggaa caagctcggc tcgcacctcg atgtgaccca ccagttcaag     2700

tcctcgacca aaaagctcgt gaagctgtcc atcaagccgt accggttcga cgtgtacctg     2760

actgacaagg gatataagtt catcaccatt tcctacctcg acgtgttgaa gaaggataac     2820

tactactaca ttccggaaca gaagtacgac aagctcaagc tcggaaaggc catcgacaaa     2880

aatgcgaagt tcatcgcgag cttctacaag aatgacttga tcaagctgga tggcgaaatc     2940

tacaagatca tcggggtcaa ctccgatacc cgcaacatga ttgagctgga tctgcccgac     3000

attcggtaca aggaatactg cgagctgaac aacatcaagg gagaaccgcg gatcaagaaa     3060

accatcggaa agaaagtgaa cagcatcgag aaactgacta ctgacgtcct gggaaacgtg     3120

ttcaccaaca cacaatacac caaaccccag ctgctgttta agcgcgggaa c              3171


<210>  23
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding for E2-K741D-L743K

<400>  23
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggatcgtgt taaacatctg ctggcagaat atgatctgct ggatctgacc      240

aatattccga aaagcaccaa tccgtatcag acccgtgtta aaggtctgaa tgaaaagctg      300

agcaaagatg aactggttat tgcactgctg catattgcaa aacgccgtgg cattcataac      360

gttgatgttg cagcagataa agaagaaacc gcaagcgata gcctgagcac caaagatcag      420

attaacaaaa acgccaaatt tctggaaagc cgctatgttt gtgaactgca gaaagaacgt      480

ctggaaaatg aaggtcatgt tcgtggtgtt gaaaatcgct ttctgacgaa agatattgtg      540

cgtgaggcca aaaaaatcat cgatacccag atgcagtatt acccggaaat tgatgaaacc      600

ttcaaagaga aatatatcag cctggttgaa acccgtcgcg aatattttga aggtccgggt      660

aaaggtagcc cgtttggttg ggaaggtaat atcaagaaat ggtttgagca gatgatgggc      720

cactgtacct attttccaga agaactgcgt agcgtcaaat atagctattc agccgaactg      780

tttaacgccc tgaatgatct gaataatctg gtgattaccc gtgatgaaga tgccaaactg      840

aattatggtg agaaattcca gatcatcgaa aacgtgttca aacagaagaa aacaccgaac      900

ctgaaacaaa tcgccattga aattggtgtg catgaaaccg aaatcaaagg ttatcgtgtg      960

aacaaaagcg gtacaccgga atttaccgaa tttaaactgt atcatgacct gaaaagcatc     1020

gtgttcgata aaagcattct ggaaaatgaa gccatcctgg atcagattgc agaaattctg     1080

accatctatc aggatgagca gagcattaaa gaggaactga ataaactgcc ggaaatactg     1140

aacgaacagg ataaagcaga aatcgccaaa ctgattggtt ataatggcac ccatcgtctg     1200

agcctgaaat gtattcacct gattaatgaa gaactgtggc agaccagccg taatcagatg     1260

gaaattttca actacctgaa catcaaaccg aacaaagtgg atctgagtga gcagaacaaa     1320

atcccgaaag atatggtgaa cgactttatt ctgagtccgg ttgtgaaacg cacctttatt     1380

cagagcatca acgtgatcaa caaagtgatc gagaaatatg gcatccccga agatatcatt     1440

atcgaactgg cacgtgaaaa taactccgat gatcgcaaaa agttcatcaa caacctgcag     1500

aaaaagaatg aagcaacccg caaacgcatt aacgaaatta ttggtcagac cggtaatcag     1560

aatgccaaac gtattgtgga aaaaatccgt ctgcatgatc agcaagaggg taaatgtctg     1620

tatagcctga aagatatccc gctggaagat ctgctgcgca atccgaacaa ttatgatatc     1680

gaccatatta ttccgcgaag cgtgagcttt gatgatagca tgcataacaa agttctggtt     1740

cgtcgcgaac agaatgccaa aaagaataat cagaccccgt atcagtatct gaccagtggt     1800

tatgcagata tcaaatacag cgtgtttaag cagcatgttc tgaatctggc cgaaaataaa     1860

gatcgcatga ccaaaaaaaa gcgcgagtat ctgctggaag aacgcgacat taacaaattt     1920

gaagtgcaga aagaatttat caaccgcaac ctggttgata cccgttatgc aacccgtgaa     1980

ctgaccaatt atctgaaagc atatttcagc gccaacaaca tgaacgtgaa agtgaaaacg     2040

attaacggca gctttaccga ttatctgcgt aaagtgtgga aattcaaaaa agaacgcaac     2100

cacggctata aacatcatgc cgaagatgcc ctgattattg caaatgcaga tttcctgttt     2160

aaagaaaaca aaaaactgaa agccgtcaac agcgtgctgg aaaaaccgga aattgagaca     2220

gatcagaaag acattcaggt tgatagcgaa gataattaca gcgaaatgtt tatcatcccg     2280

aaacaggtgc aggatatcaa agattttcgc aacttcaaat atagccaccg cgttgacaaa     2340

aaacctaatc gtcagctgat taacgatacc ctgtatagca cccgcaaaaa agataacagc     2400

acctatattg tgcagaccat taaagacatc tacgccaaag ataataccac cctgaaaaaa     2460

cagttcgaca aaagcccaga aaaatttctg atgtatcagc atgatccgcg taccttcgaa     2520

aaactggaag ttattatgaa acagtatgcc aacgagaaaa atccgctggc caaatatcac     2580

gaagaaaccg gtgaatatct gaccaaatat tccaagaaga acaacggtcc gatcgttaaa     2640

tccctgaaat atatcggtaa taaactgggc agccatctgg atgttaccca tcagtttaaa     2700

agctccacaa agaagctggt taaactgtcc atcaaaccgt atcgctttga tgtgtatctg     2760

accgacaaag gctataaatt cattaccatc agctatctgg acgtgctgaa aaaagacaac     2820

tattattata tcccggaaca gaaatatgat aaactgaaac tgggtaaagc catcgataaa     2880

aacgccaaat ttatcgccag cttctacaaa aacgacctga ttaaactgga tggcgagatc     2940

tataaaatca tcggtgttaa tagcgacacc cgcaatatga ttgagctgga tctgccggat     3000

attcgctata aagaatattg cgaactgaac aacattaaag gcgaaccgcg tatcaaaaag     3060

accatcggca aaaaagtgaa tagcatcgag aaactgacca ccgatgttct gggtaatgtg     3120

tttaccaata cccagtatac caaacctcag ctgctgttca aacgcggtaa t              3171


<210>  24
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding for E2-S670T-N675D

<400>  24
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggatcgtgt taaacatctg ctggcagaat atgatctgct ggatctgacc      240

aatattccga aaagcaccaa tccgtatcag acccgtgtta aaggtctgaa tgaaaagctg      300

agcaaagatg aactggttat tgcactgctg catattgcaa aacgccgtgg cattcataac      360

gttgatgttg cagcagataa agaagaaacc gcaagcgata gcctgagcac caaagatcag      420

attaacaaaa acgccaaatt tctggaaagc cgctatgttt gtgaactgca gaaagaacgt      480

ctggaaaatg aaggtcatgt tcgtggtgtt gaaaatcgct ttctgacgaa agatattgtg      540

cgtgaggcca aaaaaatcat cgatacccag atgcagtatt acccggaaat tgatgaaacc      600

ttcaaagaga aatatatcag cctggttgaa acccgtcgcg aatattttga aggtccgggt      660

aaaggtagcc cgtttggttg ggaaggtaat atcaagaaat ggtttgagca gatgatgggc      720

cactgtacct attttccaga agaactgcgt agcgtcaaat atagctattc agccgaactg      780

tttaacgccc tgaatgatct gaataatctg gtgattaccc gtgatgaaga tgccaaactg      840

aattatggtg agaaattcca gatcatcgaa aacgtgttca aacagaagaa aacaccgaac      900

ctgaaacaaa tcgccattga aattggtgtg catgaaaccg aaatcaaagg ttatcgtgtg      960

aacaaaagcg gtacaccgga atttaccgaa tttaaactgt atcatgacct gaaaagcatc     1020

gtgttcgata aaagcattct ggaaaatgaa gccatcctgg atcagattgc agaaattctg     1080

accatctatc aggatgagca gagcattaaa gaggaactga ataaactgcc ggaaatactg     1140

aacgaacagg ataaagcaga aatcgccaaa ctgattggtt ataatggcac ccatcgtctg     1200

agcctgaaat gtattcacct gattaatgaa gaactgtggc agaccagccg taatcagatg     1260

gaaattttca actacctgaa catcaaaccg aacaaagtgg atctgagtga gcagaacaaa     1320

atcccgaaag atatggtgaa cgactttatt ctgagtccgg ttgtgaaacg cacctttatt     1380

cagagcatca acgtgatcaa caaagtgatc gagaaatatg gcatccccga agatatcatt     1440

atcgaactgg cacgtgaaaa taactccgat gatcgcaaaa agttcatcaa caacctgcag     1500

aaaaagaatg aagcaacccg caaacgcatt aacgaaatta ttggtcagac cggtaatcag     1560

aatgccaaac gtattgtgga aaaaatccgt ctgcatgatc agcaagaggg taaatgtctg     1620

tatagcctga aagatatccc gctggaagat ctgctgcgca atccgaacaa ttatgatatc     1680

gaccatatta ttccgcgaag cgtgagcttt gatgatagca tgcataacaa agttctggtt     1740

cgtcgcgaac agaatgccaa aaagaataat cagaccccgt atcagtatct gaccagtggt     1800

tatgcagata tcaaatacag cgtgtttaag cagcatgttc tgaatctggc cgaaaataaa     1860

gatcgcatga ccaaaaaaaa gcgcgagtat ctgctggaag aacgcgacat taacaaattt     1920

gaagtgcaga aagaatttat caaccgcaac ctggttgata cccgttatgc aacccgtgaa     1980

ctgaccaatt atctgaaagc atatttcacc gccaacaaca tggatgtgaa agtgaaaacg     2040

attaacggca gctttaccga ttatctgcgt aaagtgtgga aattcaaaaa agaacgcaac     2100

cacggctata aacatcatgc cgaagatgcc ctgattattg caaatgcaga tttcctgttt     2160

aaagaaaaca aaaaactgaa agccgtcaac agcgtgctgg aaaaaccgga aattgagaca     2220

aaacagctgg acattcaggt tgatagcgaa gataattaca gcgaaatgtt tatcatcccg     2280

aaacaggtgc aggatatcaa agattttcgc aacttcaaat atagccaccg cgttgacaaa     2340

aaacctaatc gtcagctgat taacgatacc ctgtatagca cccgcaaaaa agataacagc     2400

acctatattg tgcagaccat taaagacatc tacgccaaag ataataccac cctgaaaaaa     2460

cagttcgaca aaagcccaga aaaatttctg atgtatcagc atgatccgcg taccttcgaa     2520

aaactggaag ttattatgaa acagtatgcc aacgagaaaa atccgctggc caaatatcac     2580

gaagaaaccg gtgaatatct gaccaaatat tccaagaaga acaacggtcc gatcgttaaa     2640

tccctgaaat atatcggtaa taaactgggc agccatctgg atgttaccca tcagtttaaa     2700

agctccacaa agaagctggt taaactgtcc atcaaaccgt atcgctttga tgtgtatctg     2760

accgacaaag gctataaatt cattaccatc agctatctgg acgtgctgaa aaaagacaac     2820

tattattata tcccggaaca gaaatatgat aaactgaaac tgggtaaagc catcgataaa     2880

aacgccaaat ttatcgccag cttctacaaa aacgacctga ttaaactgga tggcgagatc     2940

tataaaatca tcggtgttaa tagcgacacc cgcaatatga ttgagctgga tctgccggat     3000

attcgctata aagaatattg cgaactgaac aacattaaag gcgaaccgcg tatcaaaaag     3060

accatcggca aaaaagtgaa tagcatcgag aaactgacca ccgatgttct gggtaatgtg     3120

tttaccaata cccagtatac caaacctcag ctgctgttca aacgcggtaa t              3171


<210>  25
<211>  3171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding for E2-K741N-L743N

<400>  25
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggatcgtgt taaacatctg ctggcagaat atgatctgct ggatctgacc      240

aatattccga aaagcaccaa tccgtatcag acccgtgtta aaggtctgaa tgaaaagctg      300

agcaaagatg aactggttat tgcactgctg catattgcaa aacgccgtgg cattcataac      360

gttgatgttg cagcagataa agaagaaacc gcaagcgata gcctgagcac caaagatcag      420

attaacaaaa acgccaaatt tctggaaagc cgctatgttt gtgaactgca gaaagaacgt      480

ctggaaaatg aaggtcatgt tcgtggtgtt gaaaatcgct ttctgacgaa agatattgtg      540

cgtgaggcca aaaaaatcat cgatacccag atgcagtatt acccggaaat tgatgaaacc      600

ttcaaagaga aatatatcag cctggttgaa acccgtcgcg aatattttga aggtccgggt      660

aaaggtagcc cgtttggttg ggaaggtaat atcaagaaat ggtttgagca gatgatgggc      720

cactgtacct attttccaga agaactgcgt agcgtcaaat atagctattc agccgaactg      780

tttaacgccc tgaatgatct gaataatctg gtgattaccc gtgatgaaga tgccaaactg      840

aattatggtg agaaattcca gatcatcgaa aacgtgttca aacagaagaa aacaccgaac      900

ctgaaacaaa tcgccattga aattggtgtg catgaaaccg aaatcaaagg ttatcgtgtg      960

aacaaaagcg gtacaccgga atttaccgaa tttaaactgt atcatgacct gaaaagcatc     1020

gtgttcgata aaagcattct ggaaaatgaa gccatcctgg atcagattgc agaaattctg     1080

accatctatc aggatgagca gagcattaaa gaggaactga ataaactgcc ggaaatactg     1140

aacgaacagg ataaagcaga aatcgccaaa ctgattggtt ataatggcac ccatcgtctg     1200

agcctgaaat gtattcacct gattaatgaa gaactgtggc agaccagccg taatcagatg     1260

gaaattttca actacctgaa catcaaaccg aacaaagtgg atctgagtga gcagaacaaa     1320

atcccgaaag atatggtgaa cgactttatt ctgagtccgg ttgtgaaacg cacctttatt     1380

cagagcatca acgtgatcaa caaagtgatc gagaaatatg gcatccccga agatatcatt     1440

atcgaactgg cacgtgaaaa taactccgat gatcgcaaaa agttcatcaa caacctgcag     1500

aaaaagaatg aagcaacccg caaacgcatt aacgaaatta ttggtcagac cggtaatcag     1560

aatgccaaac gtattgtgga aaaaatccgt ctgcatgatc agcaagaggg taaatgtctg     1620

tatagcctga aagatatccc gctggaagat ctgctgcgca atccgaacaa ttatgatatc     1680

gaccatatta ttccgcgaag cgtgagcttt gatgatagca tgcataacaa agttctggtt     1740

cgtcgcgaac agaatgccaa aaagaataat cagaccccgt atcagtatct gaccagtggt     1800

tatgcagata tcaaatacag cgtgtttaag cagcatgttc tgaatctggc cgaaaataaa     1860

gatcgcatga ccaaaaaaaa gcgcgagtat ctgctggaag aacgcgacat taacaaattt     1920

gaagtgcaga aagaatttat caaccgcaac ctggttgata cccgttatgc aacccgtgaa     1980

ctgaccaatt atctgaaagc atatttcagc gccaacaaca tgaacgtgaa agtgaaaacg     2040

attaacggca gctttaccga ttatctgcgt aaagtgtgga aattcaaaaa agaacgcaac     2100

cacggctata aacatcatgc cgaagatgcc ctgattattg caaatgcaga tttcctgttt     2160

aaagaaaaca aaaaactgaa agccgtcaac agcgtgctgg aaaaaccgga aattgagaca     2220

aatcagaatg acattcaggt tgatagcgaa gataattaca gcgaaatgtt tatcatcccg     2280

aaacaggtgc aggatatcaa agattttcgc aacttcaaat atagccaccg cgttgacaaa     2340

aaacctaatc gtcagctgat taacgatacc ctgtatagca cccgcaaaaa agataacagc     2400

acctatattg tgcagaccat taaagacatc tacgccaaag ataataccac cctgaaaaaa     2460

cagttcgaca aaagcccaga aaaatttctg atgtatcagc atgatccgcg taccttcgaa     2520

aaactggaag ttattatgaa acagtatgcc aacgagaaaa atccgctggc caaatatcac     2580

gaagaaaccg gtgaatatct gaccaaatat tccaagaaga acaacggtcc gatcgttaaa     2640

tccctgaaat atatcggtaa taaactgggc agccatctgg atgttaccca tcagtttaaa     2700

agctccacaa agaagctggt taaactgtcc atcaaaccgt atcgctttga tgtgtatctg     2760

accgacaaag gctataaatt cattaccatc agctatctgg acgtgctgaa aaaagacaac     2820

tattattata tcccggaaca gaaatatgat aaactgaaac tgggtaaagc catcgataaa     2880

aacgccaaat ttatcgccag cttctacaaa aacgacctga ttaaactgga tggcgagatc     2940

tataaaatca tcggtgttaa tagcgacacc cgcaatatga ttgagctgga tctgccggat     3000

attcgctata aagaatattg cgaactgaac aacattaaag gcgaaccgcg tatcaaaaag     3060

accatcggca aaaaagtgaa tagcatcgag aaactgacca ccgatgttct gggtaatgtg     3120

tttaccaata cccagtatac caaacctcag ctgctgttca aacgcggtaa t              3171


<210>  26
<211>  3159
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding F8

<400>  26
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggaacgtgt taaaagcctg ctgagcgaat ataagattat tagcggtctg      240

gcaccgacca ataatcagcc gtataacatt cgtgttaaag gtctgaccga acagctgacc      300

aaagatgaac tggcagttgc actgctgcat attgccaaac gccgtggcat tcataaaatc      360

gatgtgattg atagcaatga cgatgtgggt aatgaactga gcaccaaaga acagctgaac      420

aaaaatagca aactgctgaa agacaaattc gtgtgtcaga ttcagctgga acgtatgaat      480

gaaggccagg ttcgtggtga aaagaatcgc tttaaaaccg cagacatcat caaagaaatt      540

atccagctgc tgaacgtgca gaaaaacttc catcagctgg atgaaaactt catcaacaaa      600

tacatcgagc tggttgaaat gcgtcgcgaa tattttgaag gtcctggtca gggtagcccg      660

tttggttgga atggtgatct gaaaaaatgg tacgaaatgc tgatgggtca ctgtacctat      720

tttccgcaag aactgcgtag cgttaaatat gcctatagcg cagacctgtt taatgcactg      780

aatgatctga acaacctgat tattcagcgc gataatagcg agaaactgga ataccatgag      840

aagtatcaca tcatcgagaa cgtgttcaag cagaaaaaaa agccgacgct gaaacaaatc      900

gcaaaagaga ttggcgttaa cccggaagat attaaaggtt atcgtattac caaaagcggt      960

acaccggaat tcaccgaatt taaactgtat cacgatctga aaagcgtgct gtttgatcag     1020

agcattctgg aaaatgaaga tgtgctggac cagattgcag aaattctgac catttatcag     1080

gacaaagaca gcatcaaaag caaactgacc gaactggata ttctgctgaa tgaagaagat     1140

aaagagaaca ttgcacagct gaccggttat aacggcacac atcgcctgag cctgaaatgt     1200

attcgtctgg tactggaaga acagtggtat agcagccgta atcagatgga aatctttacc     1260

catctgaaca ttaaaccgaa gaaaatcaat ctgaccgcag ccaacaaaat tccgaaagcc     1320

atgattgatg agtttattct gagtccggtt gtgaaacgca cctttattca gagcatcaac     1380

gtgatcaaca aagtgatcga gaaatatggc atccccgaag atatcattat cgaactggca     1440

cgtgaaaata actccgatga tcgcaaaaag ttcatcaaca acctgcagaa aaagaatgaa     1500

gcaacccgca aacgcattaa cgaaattatt ggtcagaccg gtaatcagaa tgccaaacgt     1560

attgtggaaa aaatccgtct gcatgatcag caagagggga aatgtctgta tagcctggaa     1620

agcattgccc tgatggatct gctgaataac ccgcagaatt atgaagtgga tcatattatt     1680

ccgcgtagcg tggcatttga taattccatt cataacaaag tgctggtgaa gcagatcgag     1740

aatagcaaaa aaggtaatcg tacgccgtat cagtatctga atagcagtga tgcaaaactg     1800

agctacaacc agtttaaaca gcatattctg aatctgagca aaagcaaaga tcgcatcagc     1860

aaaaaaaaga aggactacct gctggaagaa cgcgatatca acaaatttga agtccagaaa     1920

gagtttatca accgcaatct ggttgatacc cgttatgcaa cccgtgaact gaccagctat     1980

ctgaaagcat atttcagcgc caataacatg gacgtgaaag tgaaaacaat taacggcagc     2040

tttaccaacc atctgcgtaa agtttggcgc tttgataaat atcgcaacca cggctataaa     2100

catcatgcag aagatgccct gattattgca aatgcagatt tcctgtttaa agaaaacaaa     2160

aaactgaaag ccgtcaacag cgtgctggaa aaaccggaaa ttgagacaaa acagctggac     2220

attcaggttg atagcgaaga taattacagc gaaatgttta tcatcccgaa acaggtgcag     2280

gatatcaaag attttcgcaa cttcaaatat agccaccgcg ttgacaaaaa acctaatcgt     2340

cagctgatta acgataccct gtatagcacc cgcaaaaaag ataacagcac ctatattgtg     2400

cagaccatta aagacatcta cgccaaagat aataccaccc tgaaaaaaca gttcgacaaa     2460

agcccagaaa aatttctgat gtatcagcat gatccgcgta ccttcgaaaa actggaagtt     2520

attatgaaac agtatgccaa cgagaaaaat ccgctggcca aatatcacga agaaaccggt     2580

gaatatctga ccaaatattc caagaagaac aacggtccga tcgttaaatc cctgaaatat     2640

atcggtaata aactgggcag ccatctggat gttacccatc agtttaaaag ctccacaaag     2700

aagctggtta aactgtccat caaaccgtat cgctttgatg tgtatctgac cgacaaaggc     2760

tataaattca ttaccatcag ctatctggac gtgctgaaaa aagacaacta ttattatatc     2820

ccggaacaga aatatgataa actgaaactg ggtaaagcca tcgataaaaa cgccaaattt     2880

atcgccagct tctacaaaaa cgacctgatt aaactggatg gcgagatcta taaaatcatc     2940

ggtgttaata gcgacacccg caatatgatt gagctggatc tgccggatat tcgctataaa     3000

gaatattgcg aactgaacaa cattaaaggc gaaccgcgta tcaaaaagac catcggcaaa     3060

aaagtgaata gcatcgagaa actgaccacc gatgttctgg gtaatgtgtt taccaatacc     3120

cagtatacca aacctcagct gctgttcaaa cgcggtaat                            3159


<210>  27
<211>  3159
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Codon-optimized F8 polynucleotide

<400>  27
atgaaccaaa agttcattct ggggctcgat atcggcatca cctccgtggg atatggtctg       60

atcgactacg agactaagaa catcatcgac gctggagtgc gactgttccc ggaagcgaac      120

gtggagaaca acgaaggccg cagatccaag cgcgggtcca gaaggctcaa gaggcggagg      180

atccatagac tcgagagagt gaagtcgctc ctttcggaat acaagattat cagcggtctt      240

gcccccacca acaaccaacc gtacaacatc agagtgaagg gcctgaccga acagctgacc      300

aaagatgaac tggccgtcgc cctgctgcat attgccaaac ggcgcggaat ccataagatc      360

gacgtgattg acagcaacga tgacgtggga aacgagctgt caaccaagga acagcttaac      420

aagaacagca aattgctgaa ggacaagttt gtctgccaaa ttcaactgga acggatgaac      480

gagggacaag tcaggggaga gaaaaaccgg ttcaagaccg ccgacatcat caaggagatc      540

atccaactgc tgaacgtgca gaagaacttc caccaactgg atgaaaactt cattaacaag      600

tacattgaac tggtggaaat gcggagggag tacttcgagg gacctggaca gggatcccct      660

ttcggctgga atggggacct taagaagtgg tacgaaatgt tgatgggcca ttgcacttac      720

tttccgcaag aactccggtc cgtgaagtac gcatactctg ccgacctgtt caatgcactc      780

aacgacctta acaacttgat catccagcgc gataactcgg aaaagttgga ataccacgaa      840

aagtatcaca tcatcgagaa cgtgttcaag cagaaaaaga agccaactct gaagcagatt      900

gccaaggaaa ttggcgtgaa tccggaggat atcaagggat accggatcac taagtccggc      960

acgccagagt tcaccgagtt caagctgtac cacgatctga agtcggtgct ctttgaccag     1020

tccatcctgg aaaacgaaga tgtgctggac cagattgctg agatcctgac catctaccag     1080

gacaaggact cgattaagtc caagctcacc gagctggaca ttctgctgaa cgaagaagat     1140

aaggagaaca tcgcgcagct caccggttac aatggtaccc accgcttgtc ccttaagtgc     1200

atccgcctgg tgctggagga acagtggtac tcgagccgga accagatgga gatcttcact     1260

cacttgaaca tcaagccgaa aaagattaac ctgactgccg ccaacaagat acccaaggcc     1320

atgatcgacg agtttatcct ctcaccggtg gtcaagcgca ccttcattca atctatcaac     1380

gtgatcaaca aggtcatcga gaagtacggc attcctgagg atatcatcat cgagctggct     1440

cgggagaaca actcagacga taggaagaag ttcattaaca acctccagaa aaagaacgag     1500

gccactcgca agcggattaa tgagatcatc ggtcagaccg ggaaccagaa cgccaagcgg     1560

atcgtggaaa agattcggct ccacgaccaa caggagggaa agtgtctgta ctcgctggag     1620

tcgattgcac tgatggacct cctgaacaac ccacagaact acgaagtcga tcacataatc     1680

ccccgcagcg tggcattcga caactccatc cataacaagg tcctcgtgaa gcagatcgag     1740

aatagcaaga aggggaaccg gactccgtac cagtacctga actcctccga cgccaagctg     1800

tcatacaatc agttcaaaca gcacattctc aacctgtcca agtcaaagga caggatctcc     1860

aagaagaaga aggactacct tctcgaggaa cgggatatca ataagttcga ggtgcagaag     1920

gagtttatca atagaaacct ggtggacact cgctatgcca cccgcgaact gaccagctac     1980

ctgaaggcgt acttctccgc caacaacatg gacgtgaagg tcaaaactat taacggcagc     2040

ttcaccaacc atctgcgcaa ggtctggagg ttcgacaagt accgcaacca cggttacaag     2100

caccacgcgg aagatgcgct gattatcgcc aacgctgact tcctgttcaa ggaaaacaag     2160

aagctcaagg ccgtgaactc agtgctcgag aagcctgaaa tcgagactaa gcagctggac     2220

atccaggtcg attcggaaga taactactcc gaaatgttca tcatccctaa gcaagtgcag     2280

gacatcaagg acttcaggaa tttcaagtac agccatcgcg tggacaagaa gccaaacaga     2340

cagctgatca acgatacact gtattccacc cggaagaagg acaactccac ctacatcgtc     2400

caaaccatta aggacatcta cgcaaaggac aacaccacgc ttaagaagca gttcgacaag     2460

agccccgaaa agttcctcat gtaccagcac gaccccagaa ccttcgagaa gcttgaagtg     2520

atcatgaagc agtacgccaa cgaaaagaac ccactggcta agtaccacga ggaaaccggc     2580

gaatacctga ccaagtactc caaaaagaac aacggaccga tcgtcaagtc cctgaagtac     2640

attgggaaca agctcggctc gcacctcgat gtgacccacc agttcaagtc ctcgaccaaa     2700

aagctcgtga agctgtccat caagccgtac cggttcgacg tgtacctgac tgacaaggga     2760

tataagttca tcaccatttc ctacctcgac gtgttgaaga aggataacta ctactacatt     2820

ccggaacaga agtacgacaa gctcaagctc ggaaaggcca tcgacaaaaa tgcgaagttc     2880

atcgcgagct tctacaagaa tgacttgatc aagctggatg gcgaaatcta caagatcatc     2940

ggggtcaact ccgatacccg caacatgatt gagctggatc tgcccgacat tcggtacaag     3000

gaatactgcg agctgaacaa catcaaggga gaaccgcgga tcaagaaaac catcggaaag     3060

aaagtgaaca gcatcgagaa actgactact gacgtcctgg gaaacgtgtt caccaacaca     3120

caatacacca aaccccagct gctgtttaag cgcgggaac                            3159


<210>  28
<211>  3159
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding F8-K737D-L739K

<400>  28
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggaacgtgt taaaagcctg ctgagcgaat ataagattat tagcggtctg      240

gcaccgacca ataatcagcc gtataacatt cgtgttaaag gtctgaccga acagctgacc      300

aaagatgaac tggcagttgc actgctgcat attgccaaac gccgtggcat tcataaaatc      360

gatgtgattg atagcaatga cgatgtgggt aatgaactga gcaccaaaga acagctgaac      420

aaaaatagca aactgctgaa agacaaattc gtgtgtcaga ttcagctgga acgtatgaat      480

gaaggccagg ttcgtggtga aaagaatcgc tttaaaaccg cagacatcat caaagaaatt      540

atccagctgc tgaacgtgca gaaaaacttc catcagctgg atgaaaactt catcaacaaa      600

tacatcgagc tggttgaaat gcgtcgcgaa tattttgaag gtcctggtca gggtagcccg      660

tttggttgga atggtgatct gaaaaaatgg tacgaaatgc tgatgggtca ctgtacctat      720

tttccgcaag aactgcgtag cgttaaatat gcctatagcg cagacctgtt taatgcactg      780

aatgatctga acaacctgat tattcagcgc gataatagcg agaaactgga ataccatgag      840

aagtatcaca tcatcgagaa cgtgttcaag cagaaaaaaa agccgacgct gaaacaaatc      900

gcaaaagaga ttggcgttaa cccggaagat attaaaggtt atcgtattac caaaagcggt      960

acaccggaat tcaccgaatt taaactgtat cacgatctga aaagcgtgct gtttgatcag     1020

agcattctgg aaaatgaaga tgtgctggac cagattgcag aaattctgac catttatcag     1080

gacaaagaca gcatcaaaag caaactgacc gaactggata ttctgctgaa tgaagaagat     1140

aaagagaaca ttgcacagct gaccggttat aacggcacac atcgcctgag cctgaaatgt     1200

attcgtctgg tactggaaga acagtggtat agcagccgta atcagatgga aatctttacc     1260

catctgaaca ttaaaccgaa gaaaatcaat ctgaccgcag ccaacaaaat tccgaaagcc     1320

atgattgatg agtttattct gagtccggtt gtgaaacgca cctttattca gagcatcaac     1380

gtgatcaaca aagtgatcga gaaatatggc atccccgaag atatcattat cgaactggca     1440

cgtgaaaata actccgatga tcgcaaaaag ttcatcaaca acctgcagaa aaagaatgaa     1500

gcaacccgca aacgcattaa cgaaattatt ggtcagaccg gtaatcagaa tgccaaacgt     1560

attgtggaaa aaatccgtct gcatgatcag caagagggga aatgtctgta tagcctggaa     1620

agcattgccc tgatggatct gctgaataac ccgcagaatt atgaagtgga tcatattatt     1680

ccgcgtagcg tggcatttga taattccatt cataacaaag tgctggtgaa gcagatcgag     1740

aatagcaaaa aaggtaatcg tacgccgtat cagtatctga atagcagtga tgcaaaactg     1800

agctacaacc agtttaaaca gcatattctg aatctgagca aaagcaaaga tcgcatcagc     1860

aaaaaaaaga aggactacct gctggaagaa cgcgatatca acaaatttga agtccagaaa     1920

gagtttatca accgcaatct ggttgatacc cgttatgcaa cccgtgaact gaccagctat     1980

ctgaaagcat atttcagcgc caataacatg gacgtgaaag tgaaaacaat taacggcagc     2040

tttaccaacc atctgcgtaa agtttggcgc tttgataaat atcgcaacca cggctataaa     2100

catcatgcag aagatgccct gattattgca aatgcagatt tcctgtttaa agaaaacaaa     2160

aaactgaaag ccgtcaacag cgtgctggaa aaaccggaaa ttgagacaga tcagaaagac     2220

attcaggttg atagcgaaga taattacagc gaaatgttta tcatcccgaa acaggtgcag     2280

gatatcaaag attttcgcaa cttcaaatat agccaccgcg ttgacaaaaa acctaatcgt     2340

cagctgatta acgataccct gtatagcacc cgcaaaaaag ataacagcac ctatattgtg     2400

cagaccatta aagacatcta cgccaaagat aataccaccc tgaaaaaaca gttcgacaaa     2460

agcccagaaa aatttctgat gtatcagcat gatccgcgta ccttcgaaaa actggaagtt     2520

attatgaaac agtatgccaa cgagaaaaat ccgctggcca aatatcacga agaaaccggt     2580

gaatatctga ccaaatattc caagaagaac aacggtccga tcgttaaatc cctgaaatat     2640

atcggtaata aactgggcag ccatctggat gttacccatc agtttaaaag ctccacaaag     2700

aagctggtta aactgtccat caaaccgtat cgctttgatg tgtatctgac cgacaaaggc     2760

tataaattca ttaccatcag ctatctggac gtgctgaaaa aagacaacta ttattatatc     2820

ccggaacaga aatatgataa actgaaactg ggtaaagcca tcgataaaaa cgccaaattt     2880

atcgccagct tctacaaaaa cgacctgatt aaactggatg gcgagatcta taaaatcatc     2940

ggtgttaata gcgacacccg caatatgatt gagctggatc tgccggatat tcgctataaa     3000

gaatattgcg aactgaacaa cattaaaggc gaaccgcgta tcaaaaagac catcggcaaa     3060

aaagtgaata gcatcgagaa actgaccacc gatgttctgg gtaatgtgtt taccaatacc     3120

cagtatacca aacctcagct gctgttcaaa cgcggtaat                            3159


<210>  29
<211>  3159
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DNA sequence encoding F8-K737N-L739N

<400>  29
atgaaccaga aatttatcct gggtctggat attggtatta ccagcgttgg ttatggcctg       60

attgattacg aaaccaaaaa cattattgat gccggtgttc gtctgtttcc ggaagcaaat      120

gttgaaaata atgaaggtcg tcgtagcaaa cgtggtagcc gtcgtctgaa acgtcgtcgt      180

attcatcgtc tggaacgtgt taaaagcctg ctgagcgaat ataagattat tagcggtctg      240

gcaccgacca ataatcagcc gtataacatt cgtgttaaag gtctgaccga acagctgacc      300

aaagatgaac tggcagttgc actgctgcat attgccaaac gccgtggcat tcataaaatc      360

gatgtgattg atagcaatga cgatgtgggt aatgaactga gcaccaaaga acagctgaac      420

aaaaatagca aactgctgaa agacaaattc gtgtgtcaga ttcagctgga acgtatgaat      480

gaaggccagg ttcgtggtga aaagaatcgc tttaaaaccg cagacatcat caaagaaatt      540

atccagctgc tgaacgtgca gaaaaacttc catcagctgg atgaaaactt catcaacaaa      600

tacatcgagc tggttgaaat gcgtcgcgaa tattttgaag gtcctggtca gggtagcccg      660

tttggttgga atggtgatct gaaaaaatgg tacgaaatgc tgatgggtca ctgtacctat      720

tttccgcaag aactgcgtag cgttaaatat gcctatagcg cagacctgtt taatgcactg      780

aatgatctga acaacctgat tattcagcgc gataatagcg agaaactgga ataccatgag      840

aagtatcaca tcatcgagaa cgtgttcaag cagaaaaaaa agccgacgct gaaacaaatc      900

gcaaaagaga ttggcgttaa cccggaagat attaaaggtt atcgtattac caaaagcggt      960

acaccggaat tcaccgaatt taaactgtat cacgatctga aaagcgtgct gtttgatcag     1020

agcattctgg aaaatgaaga tgtgctggac cagattgcag aaattctgac catttatcag     1080

gacaaagaca gcatcaaaag caaactgacc gaactggata ttctgctgaa tgaagaagat     1140

aaagagaaca ttgcacagct gaccggttat aacggcacac atcgcctgag cctgaaatgt     1200

attcgtctgg tactggaaga acagtggtat agcagccgta atcagatgga aatctttacc     1260

catctgaaca ttaaaccgaa gaaaatcaat ctgaccgcag ccaacaaaat tccgaaagcc     1320

atgattgatg agtttattct gagtccggtt gtgaaacgca cctttattca gagcatcaac     1380

gtgatcaaca aagtgatcga gaaatatggc atccccgaag atatcattat cgaactggca     1440

cgtgaaaata actccgatga tcgcaaaaag ttcatcaaca acctgcagaa aaagaatgaa     1500

gcaacccgca aacgcattaa cgaaattatt ggtcagaccg gtaatcagaa tgccaaacgt     1560

attgtggaaa aaatccgtct gcatgatcag caagagggga aatgtctgta tagcctggaa     1620

agcattgccc tgatggatct gctgaataac ccgcagaatt atgaagtgga tcatattatt     1680

ccgcgtagcg tggcatttga taattccatt cataacaaag tgctggtgaa gcagatcgag     1740

aatagcaaaa aaggtaatcg tacgccgtat cagtatctga atagcagtga tgcaaaactg     1800

agctacaacc agtttaaaca gcatattctg aatctgagca aaagcaaaga tcgcatcagc     1860

aaaaaaaaga aggactacct gctggaagaa cgcgatatca acaaatttga agtccagaaa     1920

gagtttatca accgcaatct ggttgatacc cgttatgcaa cccgtgaact gaccagctat     1980

ctgaaagcat atttcagcgc caataacatg gacgtgaaag tgaaaacaat taacggcagc     2040

tttaccaacc atctgcgtaa agtttggcgc tttgataaat atcgcaacca cggctataaa     2100

catcatgcag aagatgccct gattattgca aatgcagatt tcctgtttaa agaaaacaaa     2160

aaactgaaag ccgtcaacag cgtgctggaa aaaccggaaa ttgagacaaa tcagaatgac     2220

attcaggttg atagcgaaga taattacagc gaaatgttta tcatcccgaa acaggtgcag     2280

gatatcaaag attttcgcaa cttcaaatat agccaccgcg ttgacaaaaa acctaatcgt     2340

cagctgatta acgataccct gtatagcacc cgcaaaaaag ataacagcac ctatattgtg     2400

cagaccatta aagacatcta cgccaaagat aataccaccc tgaaaaaaca gttcgacaaa     2460

agcccagaaa aatttctgat gtatcagcat gatccgcgta ccttcgaaaa actggaagtt     2520

attatgaaac agtatgccaa cgagaaaaat ccgctggcca aatatcacga agaaaccggt     2580

gaatatctga ccaaatattc caagaagaac aacggtccga tcgttaaatc cctgaaatat     2640

atcggtaata aactgggcag ccatctggat gttacccatc agtttaaaag ctccacaaag     2700

aagctggtta aactgtccat caaaccgtat cgctttgatg tgtatctgac cgacaaaggc     2760

tataaattca ttaccatcag ctatctggac gtgctgaaaa aagacaacta ttattatatc     2820

ccggaacaga aatatgataa actgaaactg ggtaaagcca tcgataaaaa cgccaaattt     2880

atcgccagct tctacaaaaa cgacctgatt aaactggatg gcgagatcta taaaatcatc     2940

ggtgttaata gcgacacccg caatatgatt gagctggatc tgccggatat tcgctataaa     3000

gaatattgcg aactgaacaa cattaaaggc gaaccgcgta tcaaaaagac catcggcaaa     3060

aaagtgaata gcatcgagaa actgaccacc gatgttctgg gtaatgtgtt taccaatacc     3120

cagtatacca aacctcagct gctgttcaaa cgcggtaat                            3159


<210>  30
<211>  1054
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis Cas9

<400>  30

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser 
65                  70                  75                  80  


Gln Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp 
        115                 120                 125             


Asp Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met 
145                 150                 155                 160 


Asn Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp 
                165                 170                 175     


Ile Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His 
            180                 185                 190         


Gln Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp 
    210                 215                 220                 


Glu Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp 
            260                 265                 270         


Gly Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu 
    290                 295                 300                 


Ile Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser 
305                 310                 315                 320 


Gly Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser 
                325                 330                 335     


Val Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln 
            340                 345                 350         


Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser 
        355                 360                 365             


Lys Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn 
    370                 375                 380                 


Ile Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln 
                405                 410                 415     


Met Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu 
            420                 425                 430         


Thr Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn 
    450                 455                 460                 


Lys Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met 
                485                 490                 495     


Gln Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly 
            500                 505                 510         


Lys Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu 
        515                 520                 525             


His Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro 
    530                 535                 540                 


Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu 
                565                 570                 575     


Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys 
    610                 615                 620                 


Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys 
        675                 680                 685             


Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu 
                725                 730                 735     


Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu 
            740                 745                 750         


Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn 
        755                 760                 765             


Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile 
785                 790                 795                 800 


Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys 
                805                 810                 815     


Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp 
            820                 825                 830         


Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn 
        835                 840                 845             


Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys 
865                 870                 875                 880 


Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe 
                885                 890                 895     


Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser 
        915                 920                 925             


Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln 
    930                 935                 940                 


Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu 
                965                 970                 975     


Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu 
            980                 985                 990         


Leu Asp Leu Pro Asp Ile Arg Tyr  Lys Glu Tyr Cys Glu  Leu Asn Asn 
        995                 1000                 1005             


Ile Lys  Gly Glu Pro Arg Ile  Lys Lys Thr Ile Gly  Lys Lys Val 
    1010                 1015                 1020             


Asn Ser  Ile Glu Lys Leu Thr  Thr Asp Val Leu Gly  Asn Val Phe 
    1025                 1030                 1035             


Thr Asn  Thr Gln Tyr Thr Lys  Pro Gln Leu Leu Phe  Lys Arg Gly 
    1040                 1045                 1050             


Asn 
    


<210>  31
<211>  1054
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri Cas9

<400>  31

Met Lys Glu Lys Tyr Ile Leu Gly Leu Asp Leu Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asn Phe Glu Thr Lys Lys Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Asp Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Leu Leu Leu Thr Glu Tyr Asp Leu Ile Asn Lys Glu 
65                  70                  75                  80  


Gln Ile Pro Thr Ser Asn Asn Pro Tyr Gln Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ile Leu Ser Lys Asp Glu Leu Ala Ile Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Asn Ile Asn Val Ser Ser Glu Asp Glu 
        115                 120                 125             


Asp Ala Ser Asn Glu Leu Ser Thr Lys Glu Gln Ile Asn Arg Asn Asn 
    130                 135                 140                 


Lys Leu Leu Lys Asp Lys Tyr Val Cys Glu Val Gln Leu Gln Arg Leu 
145                 150                 155                 160 


Lys Glu Gly Gln Ile Arg Gly Glu Lys Asn Arg Phe Lys Thr Thr Asp 
                165                 170                 175     


Ile Leu Lys Glu Ile Asp Gln Leu Leu Lys Val Gln Lys Asp Tyr His 
            180                 185                 190         


Asn Leu Asp Ile Asp Phe Ile Asn Gln Tyr Lys Glu Ile Val Glu Thr 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro Phe Gly Trp 
    210                 215                 220                 


Asn Gly Asp Leu Lys Lys Trp Tyr Glu Met Leu Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile Gln Arg Asp 
            260                 265                 270         


Asn Ser Glu Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu 
    290                 295                 300                 


Ile Gly Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser 
305                 310                 315                 320 


Gly Thr Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser 
                325                 330                 335     


Ile Val Phe Asp Lys Ser Ile Leu Glu Asn Glu Ala Ile Leu Asp Gln 
            340                 345                 350         


Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Glu Gln Ser Ile Lys Glu 
        355                 360                 365             


Glu Leu Asn Lys Leu Pro Glu Ile Leu Asn Glu Gln Asp Lys Ala Glu 
    370                 375                 380                 


Ile Ala Lys Leu Ile Gly Tyr Asn Gly Thr His Arg Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Ile His Leu Ile Asn Glu Glu Leu Trp Gln Thr Ser Arg Asn Gln 
                405                 410                 415     


Met Glu Ile Phe Asn Tyr Leu Asn Ile Lys Pro Asn Lys Val Asp Leu 
            420                 425                 430         


Ser Glu Gln Asn Lys Ile Pro Lys Asp Met Val Asn Asp Phe Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Thr Phe Ile Gln Ser Ile Asn Val Ile Asn 
    450                 455                 460                 


Lys Val Ile Glu Lys Tyr Gly Ile Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Asp Asp Arg Lys Lys Phe Ile Asn Asn Leu 
                485                 490                 495     


Gln Lys Lys Asn Glu Ala Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly 
            500                 505                 510         


Gln Thr Gly Asn Gln Asn Ala Lys Arg Ile Val Glu Lys Ile Arg Leu 
        515                 520                 525             


His Asp Gln Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Ala 
    530                 535                 540                 


Leu Met Asp Leu Leu Asn Asn Pro Gln Asn Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ala Phe Asp Asn Ser Ile His Asn Lys Val Leu 
                565                 570                 575     


Val Lys Gln Ile Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Leu Asn Ser Ser Asp Ala Lys Leu Ser Tyr Asn Gln Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Ser Lys Asp Arg Ile Ser Lys Lys Lys 
    610                 615                 620                 


Lys Asp Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Ser Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asp 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asn His Leu Arg Lys 
        675                 680                 685             


Val Trp Arg Phe Asp Lys Tyr Arg Asn His Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Lys Lys Leu Gln Asn Thr Asn Lys Ile Leu Glu Lys Pro Thr Ile Glu 
                725                 730                 735     


Asn Asn Thr Lys Lys Val Thr Val Glu Lys Glu Glu Asp Tyr Asn Asn 
            740                 745                 750         


Val Phe Glu Thr Pro Lys Leu Val Glu Asp Ile Lys Gln Tyr Arg Asp 
        755                 760                 765             


Tyr Lys Phe Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Met Lys Asp Glu His Asp Tyr Ile 
785                 790                 795                 800 


Val Gln Thr Ile Thr Asp Ile Tyr Gly Lys Asp Asn Thr Asn Leu Lys 
                805                 810                 815     


Lys Gln Phe Asn Lys Asn Pro Glu Lys Phe Leu Met Tyr Gln Asn Asp 
            820                 825                 830         


Pro Lys Thr Phe Glu Lys Leu Ser Ile Ile Met Lys Gln Tyr Ser Asp 
        835                 840                 845             


Glu Lys Asn Pro Leu Ala Lys Tyr Tyr Glu Glu Thr Gly Glu Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Lys Ile Lys 
865                 870                 875                 880 


Leu Leu Gly Asn Lys Val Gly Asn His Leu Asp Val Thr Asn Lys Tyr 
                885                 890                 895     


Glu Asn Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Asn Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Thr Glu Lys Gly Tyr Lys Phe Val Thr Ile Ala 
        915                 920                 925             


Tyr Leu Asn Val Phe Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Lys Asp 
    930                 935                 940                 


Lys Tyr Gln Glu Leu Lys Glu Lys Lys Lys Ile Lys Asp Thr Asp Gln 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asn Gly Asp 
                965                 970                 975     


Leu Tyr Lys Ile Ile Gly Val Asn Ser Asp Asp Arg Asn Ile Ile Glu 
            980                 985                 990         


Leu Asp Tyr Tyr Asp Ile Lys Tyr  Lys Asp Tyr Cys Glu  Ile Asn Asn 
        995                 1000                 1005             


Ile Lys  Gly Glu Pro Arg Ile  Lys Lys Thr Ile Gly  Lys Lys Thr 
    1010                 1015                 1020             


Glu Ser  Ile Glu Lys Phe Thr  Thr Asp Val Leu Gly  Asn Leu Tyr 
    1025                 1030                 1035             


Leu His  Ser Thr Glu Lys Ala  Pro Gln Leu Ile Phe  Lys Arg Gly 
    1040                 1045                 1050             


Leu 
    


<210>  32
<211>  1051
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus Cas9

<400>  32

Met Asn Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Val Asp Ser Asp Thr Arg Glu Ile Lys Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Pro Glu Ala Asn Val Asp Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu Asp 
    50                  55                  60                  


Arg Val Lys His Leu Leu Ala Glu Tyr Asp Leu Leu Asp Leu Thr Asn 
65                  70                  75                  80  


Ile Pro Lys Ser Thr Asn Pro Tyr Gln Thr Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Lys Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Asn Val Asn Val Met Met Asp Asp Asn Asp 
        115                 120                 125             


Ser Gly Asn Glu Leu Ser Thr Lys Asp Gln Leu Lys Lys Asn Ala Lys 
    130                 135                 140                 


Ala Leu Ser Asp Lys Tyr Val Cys Glu Leu Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Gln Asp Tyr Lys Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Glu Asp 
                165                 170                 175     


Phe Val Arg Glu Ala Arg Lys Leu Leu Glu Thr Gln Ser Lys Phe Phe 
            180                 185                 190         


Glu Ile Asp Gln Thr Phe Ile Met Arg Tyr Ile Glu Leu Ile Glu Thr 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Phe Gly Trp 
    210                 215                 220                 


Glu Gly Asn Ile Lys Lys Trp Phe Glu Gln Met Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ser Tyr Ser Ala Glu 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp 
            260                 265                 270         


Glu Asp Ala Lys Leu Asn Tyr Gly Glu Lys Phe Gln Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Thr Pro Asn Leu Lys Gln Ile Ala Ile Glu 
    290                 295                 300                 


Ile Gly Val His Glu Thr Glu Ile Lys Gly Tyr Arg Val Asn Lys Ser 
305                 310                 315                 320 


Gly Lys Pro Glu Phe Thr Gln Phe Lys Leu Tyr His Asp Leu Lys Asn 
                325                 330                 335     


Ile Phe Lys Asp Pro Lys Tyr Leu Asn Asp Ile Gln Leu Met Asp Asn 
            340                 345                 350         


Ile Ala Glu Ile Ile Thr Ile Tyr Gln Asp Ala Glu Ser Ile Ile Lys 
        355                 360                 365             


Glu Leu Asn Gln Leu Pro Glu Leu Leu Ser Glu Arg Glu Lys Glu Lys 
    370                 375                 380                 


Ile Ser Ala Leu Ser Gly Tyr Ser Gly Thr His Arg Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Ile Asn Leu Leu Leu Asp Asp Leu Trp Glu Ser Ser Leu Asn Gln 
                405                 410                 415     


Met Glu Leu Phe Thr Lys Leu Asn Leu Lys Pro Lys Lys Ile Asp Leu 
            420                 425                 430         


Ser Gln Gln His Lys Ile Pro Ser Lys Leu Val Asp Asp Phe Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Ala Phe Ile Gln Ser Ile Gln Val Val Asn 
    450                 455                 460                 


Ala Ile Ile Asp Lys Tyr Gly Leu Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Asp Asp Arg Arg Lys Phe Leu Asn Gln Leu 
                485                 490                 495     


Gln Lys Gln Asn Glu Glu Thr Arg Lys Gln Val Glu Lys Val Leu Arg 
            500                 505                 510         


Glu Tyr Gly Asn Asp Asn Ala Lys Arg Ile Val Gln Lys Ile Lys Leu 
        515                 520                 525             


His Asn Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Lys Asp Ile Pro 
    530                 535                 540                 


Leu Glu Asp Leu Leu Arg Asn Pro His His Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ala Phe Asp Asn Ser Met His Asn Lys Val Leu 
                565                 570                 575     


Val Arg Ala Asp Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Leu Asn Ser Ser Glu Ser Ser Leu Ser Tyr Asn Glu Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Thr Lys Asp Arg Ile Thr Lys Lys Lys 
    610                 615                 620                 


Arg Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Asp Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Ser Leu Leu Lys Ala Tyr Phe Ser Ala Asn Asn Leu Asp 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asn Tyr Leu Arg Lys 
        675                 680                 685             


Val Trp Lys Phe Asp Lys Asp Arg Asn Lys Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys His Asn 
705                 710                 715                 720 


Lys Lys Leu Arg Asn Ile Asn Lys Val Leu Asp Ala Pro Ser Lys Glu 
                725                 730                 735     


Val Asp Lys Lys Arg Val Thr Val Gln Ser Glu Asp Glu Tyr Asn Gln 
            740                 745                 750         


Ile Phe Glu Asp Thr Gln Lys Ala Gln Ala Ile Lys Lys Phe Glu Ile 
        755                 760                 765             


Arg Lys Phe Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Asn Ile Asp Gly Ile Glu Tyr Val 
785                 790                 795                 800 


Val Glu Ser Ile Lys Asp Ile Tyr Ser Val Asn Asn Asp Lys Val Lys 
                805                 810                 815     


Thr Lys Phe Lys Lys Asp Pro His Arg Leu Leu Met Tyr Arg Asn Asp 
            820                 825                 830         


Pro Gln Thr Phe Glu Lys Phe Glu Lys Val Phe Lys Gln Tyr Glu Ser 
        835                 840                 845             


Glu Lys Asn Pro Phe Ala Lys Tyr Tyr Glu Glu Thr Gly Glu Lys Ile 
    850                 855                 860                 


Arg Lys Phe Ser Lys Thr Gly Gln Gly Pro Tyr Ile Asn Lys Ile Lys 
865                 870                 875                 880 


Tyr Leu Arg Glu Arg Leu Gly Arg His Cys Asp Val Thr Asn Lys Tyr 
                885                 890                 895     


Ile Asn Ser Arg Asn Lys Ile Val Gln Leu Lys Ile Tyr Ser Tyr Arg 
            900                 905                 910         


Phe Asp Ile Tyr Gln Tyr Gly Asn Asn Tyr Lys Met Ile Thr Ile Ser 
        915                 920                 925             


Tyr Ile Asp Leu Glu Gln Lys Ser Asn Tyr Tyr Tyr Ile Ser Arg Glu 
    930                 935                 940                 


Lys Tyr Glu Gln Lys Lys Lys Asp Lys Gln Ile Asp Asp Ser Tyr Lys 
945                 950                 955                 960 


Phe Ile Gly Ser Phe Tyr Lys Asn Asp Ile Ile Asn Tyr Asn Gly Glu 
                965                 970                 975     


Met Tyr Arg Val Ile Gly Val Asn Asp Ser Glu Lys Asn Lys Ile Gln 
            980                 985                 990         


Leu Asp Met Ile Asp Ile Ser Ile  Lys Asp Tyr Met Glu  Leu Asn Asn 
        995                 1000                 1005             


Ile Lys  Lys Thr Gly Val Ile  Tyr Lys Thr Ile Gly  Lys Ser Thr 
    1010                 1015                 1020             


Thr His  Ile Glu Lys Tyr Thr  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1025                 1030                 1035             


Lys Ala  Ala Pro Pro Lys Lys  Pro Gln Leu Ile Phe  Lys 
    1040                 1045                 1050     


<210>  33
<211>  1052
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti Cas9

<400>  33

Met Glu Lys Asp Tyr Ile Leu Gly Leu Asp Ile Gly Ile Gly Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Asp Thr Lys Ser Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Ala Asp Asn Asn Leu Gly Arg Arg 
        35                  40                  45              


Ala Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Ser Leu Leu Ser Glu Tyr Lys Ile Ile Ser Gly Leu 
65                  70                  75                  80  


Ala Pro Thr Asn Asn Gln Pro Tyr Asn Ile Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Lys Asp Glu Leu Ala Val Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Asn Val Asp Val Ala Ala Asp Lys Glu Glu 
        115                 120                 125             


Thr Ala Ser Asp Ser Leu Ser Thr Lys Asp Gln Ile Asn Lys Asn Ala 
    130                 135                 140                 


Lys Phe Leu Glu Ser Arg Tyr Val Cys Glu Leu Gln Lys Glu Arg Leu 
145                 150                 155                 160 


Glu Asn Glu Gly His Val Arg Gly Val Glu Asn Arg Phe Leu Thr Lys 
                165                 170                 175     


Asp Ile Val Arg Glu Ala Lys Lys Ile Ile Asp Thr Gln Met Gln Tyr 
            180                 185                 190         


Tyr Pro Glu Ile Asp Glu Thr Phe Lys Glu Lys Tyr Ile Ser Leu Val 
        195                 200                 205             


Glu Thr Arg Arg Glu Tyr Tyr Glu Gly Pro Gly Lys Gly Ser Pro Tyr 
    210                 215                 220                 


Gly Trp Asp Ala Asp Val Lys Lys Trp Tyr Gln Leu Met Met Gly His 
225                 230                 235                 240 


Cys Thr Tyr Phe Pro Val Glu Phe Arg Ser Val Lys Tyr Ala Tyr Thr 
                245                 250                 255     


Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Thr Ile Ala 
            260                 265                 270         


Arg Asp Asp Asn Pro Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile 
        275                 280                 285             


Glu Asn Val Phe Lys Gln Lys Arg Asn Pro Thr Leu Lys Gln Ile Ala 
    290                 295                 300                 


Lys Glu Ile Gly Val Asn Asp Ile Asn Ile Ser Gly Tyr Arg Val Thr 
305                 310                 315                 320 


Lys Ser Gly Lys Pro Gln Phe Thr Ser Phe Lys Leu Phe His Asp Leu 
                325                 330                 335     


Lys Lys Val Val Lys Asp His Ala Ile Leu Asp Asp Ile Asp Leu Leu 
            340                 345                 350         


Asn Gln Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile 
        355                 360                 365             


Val Ala Glu Leu Gly Gln Leu Glu Tyr Leu Met Ser Glu Ala Asp Lys 
    370                 375                 380                 


Gln Ser Ile Ser Glu Leu Thr Gly Tyr Thr Gly Thr His Ser Leu Ser 
385                 390                 395                 400 


Leu Lys Cys Met Asn Met Ile Ile Asp Glu Leu Trp His Ser Ser Met 
                405                 410                 415     


Asn Gln Met Glu Val Phe Thr Tyr Leu Asn Met Arg Pro Lys Lys Tyr 
            420                 425                 430         


Glu Leu Lys Gly Tyr Gln Arg Ile Pro Thr Asp Met Ile Asp Asp Ala 
        435                 440                 445             


Ile Leu Ser Pro Val Val Lys Arg Ser Phe Lys Gln Ala Ile Gly Val 
    450                 455                 460                 


Val Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Lys Asp Ile Ile Ile 
465                 470                 475                 480 


Glu Leu Ala Arg Glu Ser Asn Ser Ala Glu Lys Ser Arg Tyr Leu Arg 
                485                 490                 495     


Ala Ile Gln Lys Lys Asn Glu Lys Thr Arg Glu Arg Ile Glu Ala Ile 
            500                 505                 510         


Ile Lys Glu Tyr Gly Asn Glu Asn Ala Lys Gly Leu Val Gln Lys Ile 
        515                 520                 525             


Lys Leu His Asp Ala Gln Glu Gly Lys Cys Leu Tyr Ser Leu Lys Asp 
    530                 535                 540                 


Ile Pro Leu Glu Asp Leu Leu Arg Asn Pro Asn Asn Tyr Asp Ile Asp 
545                 550                 555                 560 


His Ile Ile Pro Arg Ser Val Ser Phe Asp Asp Ser Met His Asn Lys 
                565                 570                 575     


Val Leu Val Arg Arg Glu Gln Asn Ala Lys Lys Asn Asn Gln Thr Pro 
            580                 585                 590         


Tyr Gln Tyr Leu Thr Ser Gly Tyr Ala Asp Ile Lys Tyr Ser Val Phe 
        595                 600                 605             


Lys Gln His Val Leu Asn Leu Ala Glu Asn Lys Asp Arg Met Thr Lys 
    610                 615                 620                 


Lys Lys Arg Glu Tyr Leu Leu Glu Glu Arg Asn Ile Asn Lys Tyr Asp 
625                 630                 635                 640 


Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Thr 
                645                 650                 655     


Thr Arg Glu Leu Thr Thr Leu Leu Lys Thr Tyr Phe Thr Ile Asn Asn 
            660                 665                 670         


Leu Asp Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Phe Leu 
        675                 680                 685             


Arg Lys Arg Trp Gly Phe Lys Lys Asn Arg Asp Glu Gly Tyr Lys His 
    690                 695                 700                 


His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Tyr Leu Phe Lys 
705                 710                 715                 720 


Glu His Lys Leu Leu Lys Glu Ile Lys Asp Val Ser Asp Leu Ala Gly 
                725                 730                 735     


Asp Glu Arg Asn Ser Asn Val Lys Asp Glu Asp Gln Tyr Glu Glu Val 
            740                 745                 750         


Phe Gly Gly Tyr Phe Lys Ile Glu Asp Ile Lys Lys Tyr Lys Ile Lys 
        755                 760                 765             


Lys Phe Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn 
    770                 775                 780                 


Asp Thr Ile Tyr Ser Thr Arg Val Lys Asp Asp Lys Arg Tyr Leu Ile 
785                 790                 795                 800 


Asn Thr Leu Lys Asn Leu Tyr Asp Lys Ser Asn Gly Asp Leu Lys Glu 
                805                 810                 815     


Arg Met Gln Lys Asp Pro Glu Ser Leu Leu Met Tyr His His Asp Pro 
            820                 825                 830         


Gln Thr Phe Glu Lys Leu Lys Ile Val Met Ser Gln Tyr Glu Asn Glu 
        835                 840                 845             


Lys Asn Pro Leu Ala Lys Tyr Phe Glu Glu Thr Gly Gln Tyr Leu Thr 
    850                 855                 860                 


Lys Tyr Ala Lys His Asp Asn Gly Pro Ala Ile His Lys Ile Lys Tyr 
865                 870                 875                 880 


Tyr Gly Asn Lys Leu Val Glu His Leu Asp Ile Thr Lys Asn Tyr His 
                885                 890                 895     


Asn Pro Gln Asn Lys Val Val Gln Leu Ser Gln Lys Ser Phe Arg Phe 
            900                 905                 910         


Asp Val Tyr Gln Thr Asp Lys Gly Tyr Lys Phe Ile Ser Ile Ala Tyr 
        915                 920                 925             


Leu Thr Leu Lys Asn Glu Lys Asn Tyr Tyr Ala Ile Ser Gln Glu Lys 
    930                 935                 940                 


Tyr Asp Gln Leu Lys Ser Glu Lys Lys Ile Ser Asn Asn Ala Val Phe 
945                 950                 955                 960 


Ile Gly Ser Phe Tyr Thr Ser Asp Ile Ile Glu Ile Asn Asn Glu Lys 
                965                 970                 975     


Phe Arg Val Ile Gly Val Asn Ser Asp Lys Asn Asn Leu Ile Glu Val 
            980                 985                 990         


Asp Arg Ile Asp Ile Arg Gln Lys  Glu Phe Ile Glu Leu  Glu Glu Glu 
        995                 1000                 1005             


Lys Lys  Asn Asn Arg Ile Lys  Val Thr Ile Gly Arg  Lys Thr Thr 
    1010                 1015                 1020             


Asn Ile  Glu Lys Phe His Thr  Asp Ile Leu Gly Asn  Met Tyr Lys 
    1025                 1030                 1035             


Ser Lys  Arg Pro Lys Ala Pro  Gln Leu Val Phe Lys  Lys Gly 
    1040                 1045                 1050         


<210>  34
<211>  67
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 1 from 8 mini-domain 
       library

<400>  34

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val 
65          


<210>  35
<211>  67
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 1 from 8 mini-domain library

<400>  35

Met Lys Glu Lys Tyr Ile Leu Gly Leu Asp Leu Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asn Phe Glu Thr Lys Lys Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Asp Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val 
65          


<210>  36
<211>  66
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 1 from 8 mini-domain library

<400>  36

Met Asn Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Val Asp Ser Asp Thr Arg Glu Ile Lys Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Pro Glu Ala Asn Val Asp Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu Asp 
    50                  55                  60                  


Arg Val 
65      


<210>  37
<211>  67
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 1 from 8 mini-domain library

<400>  37

Met Glu Lys Asp Tyr Ile Leu Gly Leu Asp Ile Gly Ile Gly Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Asp Thr Lys Ser Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Ala Asp Asn Asn Leu Gly Arg Arg 
        35                  40                  45              


Ala Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val 
65          


<210>  38
<211>  52
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 2 from 8 mini-domain 
       library

<400>  38

Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser Gln Ile Pro 
1               5                   10                  15      


Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu Ser Glu Ala 
            20                  25                  30          


Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile Ala Lys Arg 
        35                  40                  45              


Arg Gly Ile His 
    50          


<210>  39
<211>  52
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 2 from 8 mini-domain library

<400>  39

Lys Leu Leu Leu Thr Glu Tyr Asp Leu Ile Asn Lys Glu Gln Ile Pro 
1               5                   10                  15      


Thr Ser Asn Asn Pro Tyr Gln Ile Arg Val Lys Gly Leu Ser Glu Ile 
            20                  25                  30          


Leu Ser Lys Asp Glu Leu Ala Ile Ala Leu Leu His Leu Ala Lys Arg 
        35                  40                  45              


Arg Gly Ile His 
    50          


<210>  40
<211>  52
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 2 from 8 mini-domain library

<400>  40

Lys His Leu Leu Ala Glu Tyr Asp Leu Leu Asp Leu Thr Asn Ile Pro 
1               5                   10                  15      


Lys Ser Thr Asn Pro Tyr Gln Thr Arg Val Lys Gly Leu Asn Glu Lys 
            20                  25                  30          


Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile Ala Lys Arg 
        35                  40                  45              


Arg Gly Ile His 
    50          


<210>  41
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 2 from 8 mini-domain library

<400>  41

Lys Ser Leu Leu Ser Glu Tyr Lys Ile Ile Ser Gly Leu Ala Pro Thr 
1               5                   10                  15      


Asn Asn Gln Pro Tyr Asn Ile Arg Val Lys Gly Leu Thr Glu Gln Leu 
            20                  25                  30          


Thr Lys Asp Glu Leu Ala Val Ala Leu Leu His Ile Ala Lys Arg Arg 
        35                  40                  45              


Gly Ile His 
    50      


<210>  42
<211>  92
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 3 from 8 mini-domain 
       library

<400>  42

Lys Ile Asp Val Ile Asp Ser Asn Asp Asp Val Gly Asn Glu Leu Ser 
1               5                   10                  15      


Thr Lys Glu Gln Leu Asn Lys Asn Ser Lys Leu Leu Lys Asp Lys Phe 
            20                  25                  30          


Val Cys Gln Ile Gln Leu Glu Arg Met Asn Glu Gly Gln Val Arg Gly 
        35                  40                  45              


Glu Lys Asn Arg Phe Lys Thr Ala Asp Ile Ile Lys Glu Ile Ile Gln 
    50                  55                  60                  


Leu Leu Asn Val Gln Lys Asn Phe His Gln Leu Asp Glu Asn Phe Ile 
65                  70                  75                  80  


Asn Lys Tyr Ile Glu Leu Val Glu Met Arg Arg Glu 
                85                  90          


<210>  43
<211>  92
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 3 from 8 mini-domain library

<400>  43

Asn Ile Asn Val Ser Ser Glu Asp Glu Asp Ala Ser Asn Glu Leu Ser 
1               5                   10                  15      


Thr Lys Glu Gln Ile Asn Arg Asn Asn Lys Leu Leu Lys Asp Lys Tyr 
            20                  25                  30          


Val Cys Glu Val Gln Leu Gln Arg Leu Lys Glu Gly Gln Ile Arg Gly 
        35                  40                  45              


Glu Lys Asn Arg Phe Lys Thr Thr Asp Ile Leu Lys Glu Ile Asp Gln 
    50                  55                  60                  


Leu Leu Lys Val Gln Lys Asp Tyr His Asn Leu Asp Ile Asp Phe Ile 
65                  70                  75                  80  


Asn Gln Tyr Lys Glu Ile Val Glu Thr Arg Arg Glu 
                85                  90          


<210>  44
<211>  93
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 3 from 8 mini-domain library

<400>  44

Asn Val Asn Val Met Met Asp Asp Asn Asp Ser Gly Asn Glu Leu Ser 
1               5                   10                  15      


Thr Lys Asp Gln Leu Lys Lys Asn Ala Lys Ala Leu Ser Asp Lys Tyr 
            20                  25                  30          


Val Cys Glu Leu Gln Leu Glu Arg Phe Glu Gln Asp Tyr Lys Val Arg 
        35                  40                  45              


Gly Glu Lys Asn Arg Phe Lys Thr Glu Asp Phe Val Arg Glu Ala Arg 
    50                  55                  60                  


Lys Leu Leu Glu Thr Gln Ser Lys Phe Phe Glu Ile Asp Gln Thr Phe 
65                  70                  75                  80  


Ile Met Arg Tyr Ile Glu Leu Ile Glu Thr Arg Arg Glu 
                85                  90              


<210>  45
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 3 from 8 mini-domain library

<400>  45

Asn Val Asp Val Ala Ala Asp Lys Glu Glu Thr Ala Ser Asp Ser Leu 
1               5                   10                  15      


Ser Thr Lys Asp Gln Ile Asn Lys Asn Ala Lys Phe Leu Glu Ser Arg 
            20                  25                  30          


Tyr Val Cys Glu Leu Gln Lys Glu Arg Leu Glu Asn Glu Gly His Val 
        35                  40                  45              


Arg Gly Val Glu Asn Arg Phe Leu Thr Lys Asp Ile Val Arg Glu Ala 
    50                  55                  60                  


Lys Lys Ile Ile Asp Thr Gln Met Gln Tyr Tyr Pro Glu Ile Asp Glu 
65                  70                  75                  80  


Thr Phe Lys Glu Lys Tyr Ile Ser Leu Val Glu Thr Arg Arg Glu 
                85                  90                  95  


<210>  46
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 4 from 8 mini-domain 
       library

<400>  46

Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp Glu Gly Asp 
1               5                   10                  15      


Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr Tyr Phe Pro 
            20                  25                  30          


Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu Phe Asn 
        35                  40                  45              


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp Gly Leu Ser 
    50                  55                  60                  


Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val Phe Lys 
65                  70                  75                  80  


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu Ile Asn Val 
                85                  90                  95      


Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly Lys 
            100                 105                 110     


<210>  47
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 4 from 8 mini-domain library

<400>  47

Tyr Phe Glu Gly Pro Gly Gln Gly Ser Pro Phe Gly Trp Asn Gly Asp 
1               5                   10                  15      


Leu Lys Lys Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
            20                  25                  30          


Gln Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu Phe Asn 
        35                  40                  45              


Ala Leu Asn Asp Leu Asn Asn Leu Ile Ile Gln Arg Asp Asn Ser Glu 
    50                  55                  60                  


Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val Phe Lys 
65                  70                  75                  80  


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Gly Val 
                85                  90                  95      


Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly Thr 
            100                 105                 110     


<210>  48
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 4 from 8 mini-domain library

<400>  48

Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Phe Gly Trp Glu Gly Asn 
1               5                   10                  15      


Ile Lys Lys Trp Phe Glu Gln Met Met Gly His Cys Thr Tyr Phe Pro 
            20                  25                  30          


Glu Glu Leu Arg Ser Val Lys Tyr Ser Tyr Ser Ala Glu Leu Phe Asn 
        35                  40                  45              


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asp Ala 
    50                  55                  60                  


Lys Leu Asn Tyr Gly Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
65                  70                  75                  80  


Gln Lys Lys Thr Pro Asn Leu Lys Gln Ile Ala Ile Glu Ile Gly Val 
                85                  90                  95      


His Glu Thr Glu Ile Lys Gly Tyr Arg Val Asn Lys Ser Gly Lys 
            100                 105                 110     


<210>  49
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 4 from 8 mini-domain library

<400>  49

Tyr Tyr Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp Asp Ala Asp 
1               5                   10                  15      


Val Lys Lys Trp Tyr Gln Leu Met Met Gly His Cys Thr Tyr Phe Pro 
            20                  25                  30          


Val Glu Phe Arg Ser Val Lys Tyr Ala Tyr Thr Ala Asp Leu Tyr Asn 
        35                  40                  45              


Ala Leu Asn Asp Leu Asn Asn Leu Thr Ile Ala Arg Asp Asp Asn Pro 
    50                  55                  60                  


Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val Phe Lys 
65                  70                  75                  80  


Gln Lys Arg Asn Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Gly Val 
                85                  90                  95      


Asn Asp Ile Asn Ile Ser Gly Tyr Arg Val Thr Lys Ser Gly Lys 
            100                 105                 110     


<210>  50
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 5 from 8 mini-domain 
       library

<400>  50

Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Val Leu 
1               5                   10                  15      


Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln Ile Ala 
            20                  25                  30          


Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser Lys Leu 
        35                  40                  45              


Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn Ile Ala 
    50                  55                  60                  


Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln Met Glu 
                85                  90                  95      


Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu Thr Ala 
            100                 105                 110         


Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu Ser Pro 
        115                 120                 125             


Val Val Lys 
    130     


<210>  51
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 5 from 8 mini-domain library

<400>  51

Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Ile Val 
1               5                   10                  15      


Phe Asp Lys Ser Ile Leu Glu Asn Glu Ala Ile Leu Asp Gln Ile Ala 
            20                  25                  30          


Glu Ile Leu Thr Ile Tyr Gln Asp Glu Gln Ser Ile Lys Glu Glu Leu 
        35                  40                  45              


Asn Lys Leu Pro Glu Ile Leu Asn Glu Gln Asp Lys Ala Glu Ile Ala 
    50                  55                  60                  


Lys Leu Ile Gly Tyr Asn Gly Thr His Arg Leu Ser Leu Lys Cys Ile 
65                  70                  75                  80  


His Leu Ile Asn Glu Glu Leu Trp Gln Thr Ser Arg Asn Gln Met Glu 
                85                  90                  95      


Ile Phe Asn Tyr Leu Asn Ile Lys Pro Asn Lys Val Asp Leu Ser Glu 
            100                 105                 110         


Gln Asn Lys Ile Pro Lys Asp Met Val Asn Asp Phe Ile Leu Ser Pro 
        115                 120                 125             


Val Val Lys 
    130     


<210>  52
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 5 from 8 mini-domain library

<400>  52

Pro Glu Phe Thr Gln Phe Lys Leu Tyr His Asp Leu Lys Asn Ile Phe 
1               5                   10                  15      


Lys Asp Pro Lys Tyr Leu Asn Asp Ile Gln Leu Met Asp Asn Ile Ala 
            20                  25                  30          


Glu Ile Ile Thr Ile Tyr Gln Asp Ala Glu Ser Ile Ile Lys Glu Leu 
        35                  40                  45              


Asn Gln Leu Pro Glu Leu Leu Ser Glu Arg Glu Lys Glu Lys Ile Ser 
    50                  55                  60                  


Ala Leu Ser Gly Tyr Ser Gly Thr His Arg Leu Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Asn Leu Leu Leu Asp Asp Leu Trp Glu Ser Ser Leu Asn Gln Met Glu 
                85                  90                  95      


Leu Phe Thr Lys Leu Asn Leu Lys Pro Lys Lys Ile Asp Leu Ser Gln 
            100                 105                 110         


Gln His Lys Ile Pro Ser Lys Leu Val Asp Asp Phe Ile Leu Ser Pro 
        115                 120                 125             


Val Val Lys 
    130     


<210>  53
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 5 from 8 mini-domain library

<400>  53

Pro Gln Phe Thr Ser Phe Lys Leu Phe His Asp Leu Lys Lys Val Val 
1               5                   10                  15      


Lys Asp His Ala Ile Leu Asp Asp Ile Asp Leu Leu Asn Gln Ile Ala 
            20                  25                  30          


Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Val Ala Glu Leu 
        35                  40                  45              


Gly Gln Leu Glu Tyr Leu Met Ser Glu Ala Asp Lys Gln Ser Ile Ser 
    50                  55                  60                  


Glu Leu Thr Gly Tyr Thr Gly Thr His Ser Leu Ser Leu Lys Cys Met 
65                  70                  75                  80  


Asn Met Ile Ile Asp Glu Leu Trp His Ser Ser Met Asn Gln Met Glu 
                85                  90                  95      


Val Phe Thr Tyr Leu Asn Met Arg Pro Lys Lys Tyr Glu Leu Lys Gly 
            100                 105                 110         


Tyr Gln Arg Ile Pro Thr Asp Met Ile Asp Asp Ala Ile Leu Ser Pro 
        115                 120                 125             


Val Val Lys 
    130     


<210>  54
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 6 from 8 mini-domain 
       library

<400>  54

Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn Lys Ile Ile Glu Lys 
1               5                   10                  15      


Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu Ala Arg Glu Asn Asn 
            20                  25                  30          


Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met Gln Lys Lys Asn Glu 
        35                  40                  45              


Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Lys Tyr Gly Asn Gln 
    50                  55                  60                  


Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu His Asp Glu Gln Glu 
65                  70                  75                  80  


Gly Lys Cys Leu Tyr Ser Leu Glu Ser 
                85                  


<210>  55
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 6 from 8 mini-domain library

<400>  55

Arg Thr Phe Ile Gln Ser Ile Asn Val Ile Asn Lys Val Ile Glu Lys 
1               5                   10                  15      


Tyr Gly Ile Pro Glu Asp Ile Ile Ile Glu Leu Ala Arg Glu Asn Asn 
            20                  25                  30          


Ser Asp Asp Arg Lys Lys Phe Ile Asn Asn Leu Gln Lys Lys Asn Glu 
        35                  40                  45              


Ala Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Gln Thr Gly Asn Gln 
    50                  55                  60                  


Asn Ala Lys Arg Ile Val Glu Lys Ile Arg Leu His Asp Gln Gln Glu 
65                  70                  75                  80  


Gly Lys Cys Leu Tyr Ser Leu Glu Ser 
                85                  


<210>  56
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 6 from 8 mini-domain library

<400>  56

Arg Ala Phe Ile Gln Ser Ile Gln Val Val Asn Ala Ile Ile Asp Lys 
1               5                   10                  15      


Tyr Gly Leu Pro Glu Asp Ile Ile Ile Glu Leu Ala Arg Glu Asn Asn 
            20                  25                  30          


Ser Asp Asp Arg Arg Lys Phe Leu Asn Gln Leu Gln Lys Gln Asn Glu 
        35                  40                  45              


Glu Thr Arg Lys Gln Val Glu Lys Val Leu Arg Glu Tyr Gly Asn Asp 
    50                  55                  60                  


Asn Ala Lys Arg Ile Val Gln Lys Ile Lys Leu His Asn Met Gln Glu 
65                  70                  75                  80  


Gly Lys Cys Leu Tyr Ser Leu Lys Asp 
                85                  


<210>  57
<211>  89
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 6 from 8 mini-domain library

<400>  57

Arg Ser Phe Lys Gln Ala Ile Gly Val Val Asn Ala Ile Ile Lys Lys 
1               5                   10                  15      


Tyr Gly Leu Pro Lys Asp Ile Ile Ile Glu Leu Ala Arg Glu Ser Asn 
            20                  25                  30          


Ser Ala Glu Lys Ser Arg Tyr Leu Arg Ala Ile Gln Lys Lys Asn Glu 
        35                  40                  45              


Lys Thr Arg Glu Arg Ile Glu Ala Ile Ile Lys Glu Tyr Gly Asn Glu 
    50                  55                  60                  


Asn Ala Lys Gly Leu Val Gln Lys Ile Lys Leu His Asp Ala Gln Glu 
65                  70                  75                  80  


Gly Lys Cys Leu Tyr Ser Leu Lys Asp 
                85                  


<210>  58
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 7 from 8 mini-domain 
       library

<400>  58

Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp 
1               5                   10                  15      


His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys 
            20                  25                  30          


Val Leu Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro 
        35                  40                  45              


Tyr Gln Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe 
    50                  55                  60                  


Lys Gln His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys 
65                  70                  75                  80  


Lys Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu 
                85                  90                  95      


Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala 
            100                 105                 110         


Thr Arg Glu Leu 
        115     


<210>  59
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 7 from 8 mini-domain library

<400>  59

Ile Ala Leu Met Asp Leu Leu Asn Asn Pro Gln Asn Tyr Glu Val Asp 
1               5                   10                  15      


His Ile Ile Pro Arg Ser Val Ala Phe Asp Asn Ser Ile His Asn Lys 
            20                  25                  30          


Val Leu Val Lys Gln Ile Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro 
        35                  40                  45              


Tyr Gln Tyr Leu Asn Ser Ser Asp Ala Lys Leu Ser Tyr Asn Gln Phe 
    50                  55                  60                  


Lys Gln His Ile Leu Asn Leu Ser Lys Ser Lys Asp Arg Ile Ser Lys 
65                  70                  75                  80  


Lys Lys Lys Asp Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu 
                85                  90                  95      


Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala 
            100                 105                 110         


Thr Arg Glu Leu 
        115     


<210>  60
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 7 from 8 mini-domain library

<400>  60

Ile Pro Leu Glu Asp Leu Leu Arg Asn Pro His His Tyr Glu Val Asp 
1               5                   10                  15      


His Ile Ile Pro Arg Ser Val Ala Phe Asp Asn Ser Met His Asn Lys 
            20                  25                  30          


Val Leu Val Arg Ala Asp Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro 
        35                  40                  45              


Tyr Gln Tyr Leu Asn Ser Ser Glu Ser Ser Leu Ser Tyr Asn Glu Phe 
    50                  55                  60                  


Lys Gln His Ile Leu Asn Leu Ser Lys Thr Lys Asp Arg Ile Thr Lys 
65                  70                  75                  80  


Lys Lys Arg Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Asp 
                85                  90                  95      


Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala 
            100                 105                 110         


Thr Arg Glu Leu 
        115     


<210>  61
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 7 from 8 mini-domain library

<400>  61

Ile Pro Leu Glu Asp Leu Leu Arg Asn Pro Asn Asn Tyr Asp Ile Asp 
1               5                   10                  15      


His Ile Ile Pro Arg Ser Val Ser Phe Asp Asp Ser Met His Asn Lys 
            20                  25                  30          


Val Leu Val Arg Arg Glu Gln Asn Ala Lys Lys Asn Asn Gln Thr Pro 
        35                  40                  45              


Tyr Gln Tyr Leu Thr Ser Gly Tyr Ala Asp Ile Lys Tyr Ser Val Phe 
    50                  55                  60                  


Lys Gln His Val Leu Asn Leu Ala Glu Asn Lys Asp Arg Met Thr Lys 
65                  70                  75                  80  


Lys Lys Arg Glu Tyr Leu Leu Glu Glu Arg Asn Ile Asn Lys Tyr Asp 
                85                  90                  95      


Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Thr 
            100                 105                 110         


Thr Arg Glu Leu 
        115     


<210>  62
<211>  396
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 8 from 8 mini-domain 
       library

<400>  62

Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn Val Lys 
1               5                   10                  15      


Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys Val Trp 
            20                  25                  30          


Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala Glu Asp 
        35                  40                  45              


Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys Lys 
    50                  55                  60                  


Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu Thr Lys 
65                  70                  75                  80  


Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu Met Phe 
                85                  90                  95      


Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn Phe Lys 
            100                 105                 110         


Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn Asp 
        115                 120                 125             


Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile Val Gln 
    130                 135                 140                 


Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys Lys Gln 
145                 150                 155                 160 


Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp Pro Arg 
                165                 170                 175     


Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn Glu Lys 
            180                 185                 190         


Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu Thr Lys 
        195                 200                 205             


Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys Tyr Ile 
    210                 215                 220                 


Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe Lys Ser 
225                 230                 235                 240 


Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg Phe Asp 
                245                 250                 255     


Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser Tyr Leu 
            260                 265                 270         


Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln Lys Tyr 
        275                 280                 285             


Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys Phe Ile 
    290                 295                 300                 


Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu Ile Tyr 
305                 310                 315                 320 


Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu Leu Asp 
                325                 330                 335     


Leu Pro Asp Ile Arg Tyr Lys Glu Tyr Cys Glu Leu Asn Asn Ile Lys 
            340                 345                 350         


Gly Glu Pro Arg Ile Lys Lys Thr Ile Gly Lys Lys Val Asn Ser Ile 
        355                 360                 365             


Glu Lys Leu Thr Thr Asp Val Leu Gly Asn Val Phe Thr Asn Thr Gln 
    370                 375                 380                 


Tyr Thr Lys Pro Gln Leu Leu Phe Lys Arg Gly Asn 
385                 390                 395     


<210>  63
<211>  396
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 8 from 8 mini-domain library

<400>  63

Thr Ser Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asp Val Lys 
1               5                   10                  15      


Val Lys Thr Ile Asn Gly Ser Phe Thr Asn His Leu Arg Lys Val Trp 
            20                  25                  30          


Arg Phe Asp Lys Tyr Arg Asn His Gly Tyr Lys His His Ala Glu Asp 
        35                  40                  45              


Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys Lys 
    50                  55                  60                  


Leu Gln Asn Thr Asn Lys Ile Leu Glu Lys Pro Thr Ile Glu Asn Asn 
65                  70                  75                  80  


Thr Lys Lys Val Thr Val Glu Lys Glu Glu Asp Tyr Asn Asn Val Phe 
                85                  90                  95      


Glu Thr Pro Lys Leu Val Glu Asp Ile Lys Gln Tyr Arg Asp Tyr Lys 
            100                 105                 110         


Phe Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn Asp 
        115                 120                 125             


Thr Leu Tyr Ser Thr Arg Met Lys Asp Glu His Asp Tyr Ile Val Gln 
    130                 135                 140                 


Thr Ile Thr Asp Ile Tyr Gly Lys Asp Asn Thr Asn Leu Lys Lys Gln 
145                 150                 155                 160 


Phe Asn Lys Asn Pro Glu Lys Phe Leu Met Tyr Gln Asn Asp Pro Lys 
                165                 170                 175     


Thr Phe Glu Lys Leu Ser Ile Ile Met Lys Gln Tyr Ser Asp Glu Lys 
            180                 185                 190         


Asn Pro Leu Ala Lys Tyr Tyr Glu Glu Thr Gly Glu Tyr Leu Thr Lys 
        195                 200                 205             


Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Lys Ile Lys Leu Leu 
    210                 215                 220                 


Gly Asn Lys Val Gly Asn His Leu Asp Val Thr Asn Lys Tyr Glu Asn 
225                 230                 235                 240 


Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Asn Tyr Arg Phe Asp 
                245                 250                 255     


Val Tyr Leu Thr Glu Lys Gly Tyr Lys Phe Val Thr Ile Ala Tyr Leu 
            260                 265                 270         


Asn Val Phe Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Lys Asp Lys Tyr 
        275                 280                 285             


Gln Glu Leu Lys Glu Lys Lys Lys Ile Lys Asp Thr Asp Gln Phe Ile 
    290                 295                 300                 


Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asn Gly Asp Leu Tyr 
305                 310                 315                 320 


Lys Ile Ile Gly Val Asn Ser Asp Asp Arg Asn Ile Ile Glu Leu Asp 
                325                 330                 335     


Tyr Tyr Asp Ile Lys Tyr Lys Asp Tyr Cys Glu Ile Asn Asn Ile Lys 
            340                 345                 350         


Gly Glu Pro Arg Ile Lys Lys Thr Ile Gly Lys Lys Thr Glu Ser Ile 
        355                 360                 365             


Glu Lys Phe Thr Thr Asp Val Leu Gly Asn Leu Tyr Leu His Ser Thr 
    370                 375                 380                 


Glu Lys Ala Pro Gln Leu Ile Phe Lys Arg Gly Leu 
385                 390                 395     


<210>  64
<211>  393
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 8 from 8 mini-domain library

<400>  64

Thr Ser Leu Leu Lys Ala Tyr Phe Ser Ala Asn Asn Leu Asp Val Lys 
1               5                   10                  15      


Val Lys Thr Ile Asn Gly Ser Phe Thr Asn Tyr Leu Arg Lys Val Trp 
            20                  25                  30          


Lys Phe Asp Lys Asp Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
        35                  40                  45              


Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys His Asn Lys Lys 
    50                  55                  60                  


Leu Arg Asn Ile Asn Lys Val Leu Asp Ala Pro Ser Lys Glu Val Asp 
65                  70                  75                  80  


Lys Lys Arg Val Thr Val Gln Ser Glu Asp Glu Tyr Asn Gln Ile Phe 
                85                  90                  95      


Glu Asp Thr Gln Lys Ala Gln Ala Ile Lys Lys Phe Glu Ile Arg Lys 
            100                 105                 110         


Phe Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn Asp 
        115                 120                 125             


Thr Leu Tyr Ser Thr Arg Asn Ile Asp Gly Ile Glu Tyr Val Val Glu 
    130                 135                 140                 


Ser Ile Lys Asp Ile Tyr Ser Val Asn Asn Asp Lys Val Lys Thr Lys 
145                 150                 155                 160 


Phe Lys Lys Asp Pro His Arg Leu Leu Met Tyr Arg Asn Asp Pro Gln 
                165                 170                 175     


Thr Phe Glu Lys Phe Glu Lys Val Phe Lys Gln Tyr Glu Ser Glu Lys 
            180                 185                 190         


Asn Pro Phe Ala Lys Tyr Tyr Glu Glu Thr Gly Glu Lys Ile Arg Lys 
        195                 200                 205             


Phe Ser Lys Thr Gly Gln Gly Pro Tyr Ile Asn Lys Ile Lys Tyr Leu 
    210                 215                 220                 


Arg Glu Arg Leu Gly Arg His Cys Asp Val Thr Asn Lys Tyr Ile Asn 
225                 230                 235                 240 


Ser Arg Asn Lys Ile Val Gln Leu Lys Ile Tyr Ser Tyr Arg Phe Asp 
                245                 250                 255     


Ile Tyr Gln Tyr Gly Asn Asn Tyr Lys Met Ile Thr Ile Ser Tyr Ile 
            260                 265                 270         


Asp Leu Glu Gln Lys Ser Asn Tyr Tyr Tyr Ile Ser Arg Glu Lys Tyr 
        275                 280                 285             


Glu Gln Lys Lys Lys Asp Lys Gln Ile Asp Asp Ser Tyr Lys Phe Ile 
    290                 295                 300                 


Gly Ser Phe Tyr Lys Asn Asp Ile Ile Asn Tyr Asn Gly Glu Met Tyr 
305                 310                 315                 320 


Arg Val Ile Gly Val Asn Asp Ser Glu Lys Asn Lys Ile Gln Leu Asp 
                325                 330                 335     


Met Ile Asp Ile Ser Ile Lys Asp Tyr Met Glu Leu Asn Asn Ile Lys 
            340                 345                 350         


Lys Thr Gly Val Ile Tyr Lys Thr Ile Gly Lys Ser Thr Thr His Ile 
        355                 360                 365             


Glu Lys Tyr Thr Thr Asp Ile Leu Gly Asn Leu Tyr Lys Ala Ala Pro 
    370                 375                 380                 


Pro Lys Lys Pro Gln Leu Ile Phe Lys 
385                 390             


<210>  65
<211>  392
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 8 from 8 mini-domain library

<400>  65

Thr Thr Leu Leu Lys Thr Tyr Phe Thr Ile Asn Asn Leu Asp Val Lys 
1               5                   10                  15      


Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Phe Leu Arg Lys Arg Trp 
            20                  25                  30          


Gly Phe Lys Lys Asn Arg Asp Glu Gly Tyr Lys His His Ala Glu Asp 
        35                  40                  45              


Ala Leu Ile Ile Ala Asn Ala Asp Tyr Leu Phe Lys Glu His Lys Leu 
    50                  55                  60                  


Leu Lys Glu Ile Lys Asp Val Ser Asp Leu Ala Gly Asp Glu Arg Asn 
65                  70                  75                  80  


Ser Asn Val Lys Asp Glu Asp Gln Tyr Glu Glu Val Phe Gly Gly Tyr 
                85                  90                  95      


Phe Lys Ile Glu Asp Ile Lys Lys Tyr Lys Ile Lys Lys Phe Ser His 
            100                 105                 110         


Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn Asp Thr Ile Tyr 
        115                 120                 125             


Ser Thr Arg Val Lys Asp Asp Lys Arg Tyr Leu Ile Asn Thr Leu Lys 
    130                 135                 140                 


Asn Leu Tyr Asp Lys Ser Asn Gly Asp Leu Lys Glu Arg Met Gln Lys 
145                 150                 155                 160 


Asp Pro Glu Ser Leu Leu Met Tyr His His Asp Pro Gln Thr Phe Glu 
                165                 170                 175     


Lys Leu Lys Ile Val Met Ser Gln Tyr Glu Asn Glu Lys Asn Pro Leu 
            180                 185                 190         


Ala Lys Tyr Phe Glu Glu Thr Gly Gln Tyr Leu Thr Lys Tyr Ala Lys 
        195                 200                 205             


His Asp Asn Gly Pro Ala Ile His Lys Ile Lys Tyr Tyr Gly Asn Lys 
    210                 215                 220                 


Leu Val Glu His Leu Asp Ile Thr Lys Asn Tyr His Asn Pro Gln Asn 
225                 230                 235                 240 


Lys Val Val Gln Leu Ser Gln Lys Ser Phe Arg Phe Asp Val Tyr Gln 
                245                 250                 255     


Thr Asp Lys Gly Tyr Lys Phe Ile Ser Ile Ala Tyr Leu Thr Leu Lys 
            260                 265                 270         


Asn Glu Lys Asn Tyr Tyr Ala Ile Ser Gln Glu Lys Tyr Asp Gln Leu 
        275                 280                 285             


Lys Ser Glu Lys Lys Ile Ser Asn Asn Ala Val Phe Ile Gly Ser Phe 
    290                 295                 300                 


Tyr Thr Ser Asp Ile Ile Glu Ile Asn Asn Glu Lys Phe Arg Val Ile 
305                 310                 315                 320 


Gly Val Asn Ser Asp Lys Asn Asn Leu Ile Glu Val Asp Arg Ile Asp 
                325                 330                 335     


Ile Arg Gln Lys Glu Phe Ile Glu Leu Glu Glu Glu Lys Lys Asn Asn 
            340                 345                 350         


Arg Ile Lys Val Thr Ile Gly Arg Lys Thr Thr Asn Ile Glu Lys Phe 
        355                 360                 365             


His Thr Asp Ile Leu Gly Asn Met Tyr Lys Ser Lys Arg Pro Lys Ala 
    370                 375                 380                 


Pro Gln Leu Val Phe Lys Lys Gly 
385                 390         


<210>  66
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 1 from 12 mini-domain 
       library

<400>  66

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val 
        35                  40      


<210>  67
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 1 from 12 mini-domain library

<400>  67

Met Lys Glu Lys Tyr Ile Leu Gly Leu Asp Leu Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asn Phe Glu Thr Lys Lys Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val 
        35                  40      


<210>  68
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 1 from 12 mini-domain library

<400>  68

Met Asn Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Val Asp Ser Asp Thr Arg Glu Ile Lys Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Pro Glu Ala Asn Val 
        35                  40  


<210>  69
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 1 from 12 mini-domain library

<400>  69

Met Glu Lys Asp Tyr Ile Leu Gly Leu Asp Ile Gly Ile Gly Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Asp Thr Lys Ser Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Ala 
        35                  40      


<210>  70
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 2 from 12 mini-domain 
       library

<400>  70

Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ser Arg Arg Leu Lys 
1               5                   10                  15      


Arg Arg Arg Ile His Arg Leu 
            20              


<210>  71
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 2from 12 mini-domain library

<400>  71

Asp Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ser Arg Arg Leu Lys 
1               5                   10                  15      


Arg Arg Arg Ile His Arg Leu 
            20              


<210>  72
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 2 from 12 mini-domain library

<400>  72

Asp Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys 
1               5                   10                  15      


Arg Arg Arg Ile His Arg Leu 
            20              


<210>  73
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 2 from 12 mini-domain library

<400>  73

Asp Asn Asn Leu Gly Arg Arg Ala Lys Arg Gly Ala Arg Arg Leu Lys 
1               5                   10                  15      


Arg Arg Arg Ile His Arg Leu 
            20              


<210>  74
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 3 from 12 mini-domain 
       library

<400>  74

Glu Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser 
1               5                   10                  15      


Gln Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu 
            20                  25                  30          


Ser Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
        35                  40                  45              


Ala Lys Arg Arg Gly Ile His 
    50                  55  


<210>  75
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 3 from 12 mini-domain library

<400>  75

Glu Arg Val Lys Leu Leu Leu Thr Glu Tyr Asp Leu Ile Asn Lys Glu 
1               5                   10                  15      


Gln Ile Pro Thr Ser Asn Asn Pro Tyr Gln Ile Arg Val Lys Gly Leu 
            20                  25                  30          


Ser Glu Ile Leu Ser Lys Asp Glu Leu Ala Ile Ala Leu Leu His Leu 
        35                  40                  45              


Ala Lys Arg Arg Gly Ile His 
    50                  55  


<210>  76
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 3 from 12 mini-domain library

<400>  76

Asp Arg Val Lys His Leu Leu Ala Glu Tyr Asp Leu Leu Asp Leu Thr 
1               5                   10                  15      


Asn Ile Pro Lys Ser Thr Asn Pro Tyr Gln Thr Arg Val Lys Gly Leu 
            20                  25                  30          


Asn Glu Lys Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
        35                  40                  45              


Ala Lys Arg Arg Gly Ile His 
    50                  55  


<210>  77
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 3 from 12 mini-domain library

<400>  77

Glu Arg Val Lys Ser Leu Leu Ser Glu Tyr Lys Ile Ile Ser Gly Leu 
1               5                   10                  15      


Ala Pro Thr Asn Asn Gln Pro Tyr Asn Ile Arg Val Lys Gly Leu Thr 
            20                  25                  30          


Glu Gln Leu Thr Lys Asp Glu Leu Ala Val Ala Leu Leu His Ile Ala 
        35                  40                  45              


Lys Arg Arg Gly Ile His 
    50                  


<210>  78
<211>  93
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 4 from 12 mini-domain 
       library

<400>  78

Lys Ile Asp Val Ile Asp Ser Asn Asp Asp Val Gly Asn Glu Leu Ser 
1               5                   10                  15      


Thr Lys Glu Gln Leu Asn Lys Asn Ser Lys Leu Leu Lys Asp Lys Phe 
            20                  25                  30          


Val Cys Gln Ile Gln Leu Glu Arg Met Asn Glu Gly Gln Val Arg Gly 
        35                  40                  45              


Glu Lys Asn Arg Phe Lys Thr Ala Asp Ile Ile Lys Glu Ile Ile Gln 
    50                  55                  60                  


Leu Leu Asn Val Gln Lys Asn Phe His Gln Leu Asp Glu Asn Phe Ile 
65                  70                  75                  80  


Asn Lys Tyr Ile Glu Leu Val Glu Met Arg Arg Glu Tyr 
                85                  90              


<210>  79
<211>  93
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 4 from 12 mini-domain library

<400>  79

Asn Ile Asn Val Ser Ser Glu Asp Glu Asp Ala Ser Asn Glu Leu Ser 
1               5                   10                  15      


Thr Lys Glu Gln Ile Asn Arg Asn Asn Lys Leu Leu Lys Asp Lys Tyr 
            20                  25                  30          


Val Cys Glu Val Gln Leu Gln Arg Leu Lys Glu Gly Gln Ile Arg Gly 
        35                  40                  45              


Glu Lys Asn Arg Phe Lys Thr Thr Asp Ile Leu Lys Glu Ile Asp Gln 
    50                  55                  60                  


Leu Leu Lys Val Gln Lys Asp Tyr His Asn Leu Asp Ile Asp Phe Ile 
65                  70                  75                  80  


Asn Gln Tyr Lys Glu Ile Val Glu Thr Arg Arg Glu Tyr 
                85                  90              


<210>  80
<211>  94
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 4 from 12 mini-domain library

<400>  80

Asn Val Asn Val Met Met Asp Asp Asn Asp Ser Gly Asn Glu Leu Ser 
1               5                   10                  15      


Thr Lys Asp Gln Leu Lys Lys Asn Ala Lys Ala Leu Ser Asp Lys Tyr 
            20                  25                  30          


Val Cys Glu Leu Gln Leu Glu Arg Phe Glu Gln Asp Tyr Lys Val Arg 
        35                  40                  45              


Gly Glu Lys Asn Arg Phe Lys Thr Glu Asp Phe Val Arg Glu Ala Arg 
    50                  55                  60                  


Lys Leu Leu Glu Thr Gln Ser Lys Phe Phe Glu Ile Asp Gln Thr Phe 
65                  70                  75                  80  


Ile Met Arg Tyr Ile Glu Leu Ile Glu Thr Arg Arg Glu Tyr 
                85                  90                  


<210>  81
<211>  96
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 4 from 12 mini-domain library

<400>  81

Asn Val Asp Val Ala Ala Asp Lys Glu Glu Thr Ala Ser Asp Ser Leu 
1               5                   10                  15      


Ser Thr Lys Asp Gln Ile Asn Lys Asn Ala Lys Phe Leu Glu Ser Arg 
            20                  25                  30          


Tyr Val Cys Glu Leu Gln Lys Glu Arg Leu Glu Asn Glu Gly His Val 
        35                  40                  45              


Arg Gly Val Glu Asn Arg Phe Leu Thr Lys Asp Ile Val Arg Glu Ala 
    50                  55                  60                  


Lys Lys Ile Ile Asp Thr Gln Met Gln Tyr Tyr Pro Glu Ile Asp Glu 
65                  70                  75                  80  


Thr Phe Lys Glu Lys Tyr Ile Ser Leu Val Glu Thr Arg Arg Glu Tyr 
                85                  90                  95      


<210>  82
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 5 from 12 mini-domain 
       library

<400>  82

Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp Glu Gly Asp Pro 
1               5                   10                  15      


Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr Tyr Phe Pro Asp 
            20                  25                  30          


Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu Phe Asn Ala 
        35                  40                  45              


Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp Gly Leu Ser Lys 
    50                  55                  60                  


Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val Phe Lys Gln 
65                  70                  75                  80  


Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu Ile Asn Val Asn 
                85                  90                  95      


Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly Lys Pro Gln 
            100                 105                 110         


Phe Thr 
        


<210>  83
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 5 from 12 mini-domain library

<400>  83

Phe Glu Gly Pro Gly Gln Gly Ser Pro Phe Gly Trp Asn Gly Asp Leu 
1               5                   10                  15      


Lys Lys Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro Gln 
            20                  25                  30          


Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu Phe Asn Ala 
        35                  40                  45              


Leu Asn Asp Leu Asn Asn Leu Ile Ile Gln Arg Asp Asn Ser Glu Lys 
    50                  55                  60                  


Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val Phe Lys Gln 
65                  70                  75                  80  


Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Gly Val Asn 
                85                  90                  95      


Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly Thr Pro Gln 
            100                 105                 110         


Phe Thr 
        


<210>  84
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 5 from 12 mini-domain library

<400>  84

Phe Glu Gly Pro Gly Lys Gly Ser Pro Phe Gly Trp Glu Gly Asn Ile 
1               5                   10                  15      


Lys Lys Trp Phe Glu Gln Met Met Gly His Cys Thr Tyr Phe Pro Glu 
            20                  25                  30          


Glu Leu Arg Ser Val Lys Tyr Ser Tyr Ser Ala Glu Leu Phe Asn Ala 
        35                  40                  45              


Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asp Ala Lys 
    50                  55                  60                  


Leu Asn Tyr Gly Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys Gln 
65                  70                  75                  80  


Lys Lys Thr Pro Asn Leu Lys Gln Ile Ala Ile Glu Ile Gly Val His 
                85                  90                  95      


Glu Thr Glu Ile Lys Gly Tyr Arg Val Asn Lys Ser Gly Lys Pro Glu 
            100                 105                 110         


Phe Thr 
        


<210>  85
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 5 from 12 mini-domain library

<400>  85

Tyr Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp Asp Ala Asp Val 
1               5                   10                  15      


Lys Lys Trp Tyr Gln Leu Met Met Gly His Cys Thr Tyr Phe Pro Val 
            20                  25                  30          


Glu Phe Arg Ser Val Lys Tyr Ala Tyr Thr Ala Asp Leu Tyr Asn Ala 
        35                  40                  45              


Leu Asn Asp Leu Asn Asn Leu Thr Ile Ala Arg Asp Asp Asn Pro Lys 
    50                  55                  60                  


Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val Phe Lys Gln 
65                  70                  75                  80  


Lys Arg Asn Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Gly Val Asn 
                85                  90                  95      


Asp Ile Asn Ile Ser Gly Tyr Arg Val Thr Lys Ser Gly Lys Pro Gln 
            100                 105                 110         


Phe Thr 
        


<210>  86
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 6 from 12 mini-domain 
       library

<400>  86

Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Val Leu Phe Asp Gln Ser 
1               5                   10                  15      


Ile Leu Glu Asn Glu Asp Val Leu Asp Gln Ile Ala Glu Ile Leu Thr 
            20                  25                  30          


Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser Lys Leu Thr Glu Leu Asp 
        35                  40                  45              


Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn Ile Ala Gln Leu Thr Gly 
    50                  55                  60                  


Tyr Thr Gly Thr His Arg Leu Ser Leu Lys Cys Ile Arg Leu Val Leu 
65                  70                  75                  80  


Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln Met Glu Ile Phe Thr His 
                85                  90                  95      


Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu Thr Ala Ala Asn Lys Ile 
            100                 105                 110         


Pro Lys Ala Met Ile Asp Glu Phe Ile Leu Ser Pro Val Val Lys Arg 
        115                 120                 125             


<210>  87
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 6 from 12 mini-domain library

<400>  87

Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Ile Val Phe Asp Lys Ser 
1               5                   10                  15      


Ile Leu Glu Asn Glu Ala Ile Leu Asp Gln Ile Ala Glu Ile Leu Thr 
            20                  25                  30          


Ile Tyr Gln Asp Glu Gln Ser Ile Lys Glu Glu Leu Asn Lys Leu Pro 
        35                  40                  45              


Glu Ile Leu Asn Glu Gln Asp Lys Ala Glu Ile Ala Lys Leu Ile Gly 
    50                  55                  60                  


Tyr Asn Gly Thr His Arg Leu Ser Leu Lys Cys Ile His Leu Ile Asn 
65                  70                  75                  80  


Glu Glu Leu Trp Gln Thr Ser Arg Asn Gln Met Glu Ile Phe Asn Tyr 
                85                  90                  95      


Leu Asn Ile Lys Pro Asn Lys Val Asp Leu Ser Glu Gln Asn Lys Ile 
            100                 105                 110         


Pro Lys Asp Met Val Asn Asp Phe Ile Leu Ser Pro Val Val Lys Arg 
        115                 120                 125             


<210>  88
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 6 from 12 mini-domain library

<400>  88

Gln Phe Lys Leu Tyr His Asp Leu Lys Asn Ile Phe Lys Asp Pro Lys 
1               5                   10                  15      


Tyr Leu Asn Asp Ile Gln Leu Met Asp Asn Ile Ala Glu Ile Ile Thr 
            20                  25                  30          


Ile Tyr Gln Asp Ala Glu Ser Ile Ile Lys Glu Leu Asn Gln Leu Pro 
        35                  40                  45              


Glu Leu Leu Ser Glu Arg Glu Lys Glu Lys Ile Ser Ala Leu Ser Gly 
    50                  55                  60                  


Tyr Ser Gly Thr His Arg Leu Ser Leu Lys Cys Ile Asn Leu Leu Leu 
65                  70                  75                  80  


Asp Asp Leu Trp Glu Ser Ser Leu Asn Gln Met Glu Leu Phe Thr Lys 
                85                  90                  95      


Leu Asn Leu Lys Pro Lys Lys Ile Asp Leu Ser Gln Gln His Lys Ile 
            100                 105                 110         


Pro Ser Lys Leu Val Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg 
        115                 120                 125             


<210>  89
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 6 from 12 mini-domain library

<400>  89

Ser Phe Lys Leu Phe His Asp Leu Lys Lys Val Val Lys Asp His Ala 
1               5                   10                  15      


Ile Leu Asp Asp Ile Asp Leu Leu Asn Gln Ile Ala Glu Ile Leu Thr 
            20                  25                  30          


Ile Tyr Gln Asp Lys Asp Ser Ile Val Ala Glu Leu Gly Gln Leu Glu 
        35                  40                  45              


Tyr Leu Met Ser Glu Ala Asp Lys Gln Ser Ile Ser Glu Leu Thr Gly 
    50                  55                  60                  


Tyr Thr Gly Thr His Ser Leu Ser Leu Lys Cys Met Asn Met Ile Ile 
65                  70                  75                  80  


Asp Glu Leu Trp His Ser Ser Met Asn Gln Met Glu Val Phe Thr Tyr 
                85                  90                  95      


Leu Asn Met Arg Pro Lys Lys Tyr Glu Leu Lys Gly Tyr Gln Arg Ile 
            100                 105                 110         


Pro Thr Asp Met Ile Asp Asp Ala Ile Leu Ser Pro Val Val Lys Arg 
        115                 120                 125             


<210>  90
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 7 from 12 mini-domain 
       library

<400>  90

Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn Lys Ile Ile Glu Lys Tyr 
1               5                   10                  15      


Gly Val Pro Glu Asp Ile Ile Ile Glu Leu Ala Arg Glu Asn Asn Ser 
            20                  25                  30          


Lys Asp Lys Gln Lys Phe Ile Asn Glu Met Gln Lys Lys Asn Glu Asn 
        35                  40                  45              


Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Lys Tyr Gly Asn Gln Asn 
    50                  55                  60                  


Ala Lys Arg Leu Val Glu Lys Ile Arg Leu His Asp Glu Gln Glu Gly 
65                  70                  75                  80  


Lys Cys Leu Tyr Ser Leu 
                85      


<210>  91
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 7 from 12 mini-domain library

<400>  91

Thr Phe Ile Gln Ser Ile Asn Val Ile Asn Lys Val Ile Glu Lys Tyr 
1               5                   10                  15      


Gly Ile Pro Glu Asp Ile Ile Ile Glu Leu Ala Arg Glu Asn Asn Ser 
            20                  25                  30          


Asp Asp Arg Lys Lys Phe Ile Asn Asn Leu Gln Lys Lys Asn Glu Ala 
        35                  40                  45              


Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Gln Thr Gly Asn Gln Asn 
    50                  55                  60                  


Ala Lys Arg Ile Val Glu Lys Ile Arg Leu His Asp Gln Gln Glu Gly 
65                  70                  75                  80  


Lys Cys Leu Tyr Ser Leu 
                85      


<210>  92
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 7 from 12 mini-domain library

<400>  92

Ala Phe Ile Gln Ser Ile Gln Val Val Asn Ala Ile Ile Asp Lys Tyr 
1               5                   10                  15      


Gly Leu Pro Glu Asp Ile Ile Ile Glu Leu Ala Arg Glu Asn Asn Ser 
            20                  25                  30          


Asp Asp Arg Arg Lys Phe Leu Asn Gln Leu Gln Lys Gln Asn Glu Glu 
        35                  40                  45              


Thr Arg Lys Gln Val Glu Lys Val Leu Arg Glu Tyr Gly Asn Asp Asn 
    50                  55                  60                  


Ala Lys Arg Ile Val Gln Lys Ile Lys Leu His Asn Met Gln Glu Gly 
65                  70                  75                  80  


Lys Cys Leu Tyr Ser Leu 
                85      


<210>  93
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 7 from 12 mini-domain library

<400>  93

Ser Phe Lys Gln Ala Ile Gly Val Val Asn Ala Ile Ile Lys Lys Tyr 
1               5                   10                  15      


Gly Leu Pro Lys Asp Ile Ile Ile Glu Leu Ala Arg Glu Ser Asn Ser 
            20                  25                  30          


Ala Glu Lys Ser Arg Tyr Leu Arg Ala Ile Gln Lys Lys Asn Glu Lys 
        35                  40                  45              


Thr Arg Glu Arg Ile Glu Ala Ile Ile Lys Glu Tyr Gly Asn Glu Asn 
    50                  55                  60                  


Ala Lys Gly Leu Val Gln Lys Ile Lys Leu His Asp Ala Gln Glu Gly 
65                  70                  75                  80  


Lys Cys Leu Tyr Ser Leu 
                85      


<210>  94
<211>  92
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 8 from 12 mini-domain 
       library

<400>  94

Glu Ser Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu 
1               5                   10                  15      


Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His 
            20                  25                  30          


Asn Lys Val Leu Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu 
        35                  40                  45              


Thr Pro Tyr Gln Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn 
    50                  55                  60                  


Gln Phe Lys Gln His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile 
65                  70                  75                  80  


Ser Lys Lys Lys Lys Glu Tyr Leu Leu Glu Glu Arg 
                85                  90          


<210>  95
<211>  92
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 8 from 12 mini-domain library

<400>  95

Glu Ser Ile Ala Leu Met Asp Leu Leu Asn Asn Pro Gln Asn Tyr Glu 
1               5                   10                  15      


Val Asp His Ile Ile Pro Arg Ser Val Ala Phe Asp Asn Ser Ile His 
            20                  25                  30          


Asn Lys Val Leu Val Lys Gln Ile Glu Asn Ser Lys Lys Gly Asn Arg 
        35                  40                  45              


Thr Pro Tyr Gln Tyr Leu Asn Ser Ser Asp Ala Lys Leu Ser Tyr Asn 
    50                  55                  60                  


Gln Phe Lys Gln His Ile Leu Asn Leu Ser Lys Ser Lys Asp Arg Ile 
65                  70                  75                  80  


Ser Lys Lys Lys Lys Asp Tyr Leu Leu Glu Glu Arg 
                85                  90          


<210>  96
<211>  92
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 8 from 12 mini-domain library

<400>  96

Lys Asp Ile Pro Leu Glu Asp Leu Leu Arg Asn Pro His His Tyr Glu 
1               5                   10                  15      


Val Asp His Ile Ile Pro Arg Ser Val Ala Phe Asp Asn Ser Met His 
            20                  25                  30          


Asn Lys Val Leu Val Arg Ala Asp Glu Asn Ser Lys Lys Gly Asn Arg 
        35                  40                  45              


Thr Pro Tyr Gln Tyr Leu Asn Ser Ser Glu Ser Ser Leu Ser Tyr Asn 
    50                  55                  60                  


Glu Phe Lys Gln His Ile Leu Asn Leu Ser Lys Thr Lys Asp Arg Ile 
65                  70                  75                  80  


Thr Lys Lys Lys Arg Glu Tyr Leu Leu Glu Glu Arg 
                85                  90          


<210>  97
<211>  92
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 8 from 12 mini-domain library

<400>  97

Lys Asp Ile Pro Leu Glu Asp Leu Leu Arg Asn Pro Asn Asn Tyr Asp 
1               5                   10                  15      


Ile Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asp Ser Met His 
            20                  25                  30          


Asn Lys Val Leu Val Arg Arg Glu Gln Asn Ala Lys Lys Asn Asn Gln 
        35                  40                  45              


Thr Pro Tyr Gln Tyr Leu Thr Ser Gly Tyr Ala Asp Ile Lys Tyr Ser 
    50                  55                  60                  


Val Phe Lys Gln His Val Leu Asn Leu Ala Glu Asn Lys Asp Arg Met 
65                  70                  75                  80  


Thr Lys Lys Lys Arg Glu Tyr Leu Leu Glu Glu Arg 
                85                  90          


<210>  98
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 9 from 12 mini-domain 
       library

<400>  98

Asp Ile Asn Lys Phe Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu 
1               5                   10                  15      


Val Asp Thr Arg Tyr Ala Thr Arg Glu Leu Thr 
            20                  25          


<210>  99
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 9 from 12 mini-domain library

<400>  99

Asp Ile Asn Lys Phe Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu 
1               5                   10                  15      


Val Asp Thr Arg Tyr Ala Thr Arg Glu Leu Thr 
            20                  25          


<210>  100
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 9 from 12 mini-domain library

<400>  100

Asp Ile Asn Lys Phe Asp Val Gln Lys Glu Phe Ile Asn Arg Asn Leu 
1               5                   10                  15      


Val Asp Thr Arg Tyr Ala Thr Arg Glu Leu Thr 
            20                  25          


<210>  101
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 9 from 12 mini-domain library

<400>  101

Asn Ile Asn Lys Tyr Asp Val Gln Lys Glu Phe Ile Asn Arg Asn Leu 
1               5                   10                  15      


Val Asp Thr Arg Tyr Thr Thr Arg Glu Leu Thr 
            20                  25          


<210>  102
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 10 from 12 mini-domain 
       library

<400>  102

Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn Val Lys Val 
1               5                   10                  15      


Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys Val Trp Lys 
            20                  25                  30          


Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala Glu Asp Ala 
        35                  40                  45              


Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys Lys Leu 
    50                  55                  60                  


<210>  103
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 10 from 12 mini-domain 
       library

<400>  103

Ser Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asp Val Lys Val 
1               5                   10                  15      


Lys Thr Ile Asn Gly Ser Phe Thr Asn His Leu Arg Lys Val Trp Arg 
            20                  25                  30          


Phe Asp Lys Tyr Arg Asn His Gly Tyr Lys His His Ala Glu Asp Ala 
        35                  40                  45              


Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys Lys Leu 
    50                  55                  60                  


<210>  104
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 10 from 12 mini-domain library

<400>  104

Ser Leu Leu Lys Ala Tyr Phe Ser Ala Asn Asn Leu Asp Val Lys Val 
1               5                   10                  15      


Lys Thr Ile Asn Gly Ser Phe Thr Asn Tyr Leu Arg Lys Val Trp Lys 
            20                  25                  30          


Phe Asp Lys Asp Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp Ala 
        35                  40                  45              


Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys His Asn Lys Lys Leu 
    50                  55                  60                  


<210>  105
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 10 from 12 mini-domain library

<400>  105

Thr Leu Leu Lys Thr Tyr Phe Thr Ile Asn Asn Leu Asp Val Lys Val 
1               5                   10                  15      


Lys Thr Ile Asn Gly Ser Phe Thr Asp Phe Leu Arg Lys Arg Trp Gly 
            20                  25                  30          


Phe Lys Lys Asn Arg Asp Glu Gly Tyr Lys His His Ala Glu Asp Ala 
        35                  40                  45              


Leu Ile Ile Ala Asn Ala Asp Tyr Leu Phe Lys Glu His Lys Leu Leu 
    50                  55                  60                  


<210>  106
<211>  186
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 11 from 12 mini-domain 
       library

<400>  106

Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu Thr Lys Gln 
1               5                   10                  15      


Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu Met Phe Ile 
            20                  25                  30          


Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn Phe Lys Tyr 
        35                  40                  45              


Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn Asp Thr 
    50                  55                  60                  


Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile Val Gln Thr 
65                  70                  75                  80  


Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys Lys Gln Phe 
                85                  90                  95      


Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp Pro Arg Thr 
            100                 105                 110         


Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn Glu Lys Asn 
        115                 120                 125             


Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu Thr Lys Tyr 
    130                 135                 140                 


Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys Tyr Ile Gly 
145                 150                 155                 160 


Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe Lys Ser Ser 
                165                 170                 175     


Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            180                 185     


<210>  107
<211>  186
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 11 from 12 mini-domain 
       library

<400>  107

Gln Asn Thr Asn Lys Ile Leu Glu Lys Pro Thr Ile Glu Asn Asn Thr 
1               5                   10                  15      


Lys Lys Val Thr Val Glu Lys Glu Glu Asp Tyr Asn Asn Val Phe Glu 
            20                  25                  30          


Thr Pro Lys Leu Val Glu Asp Ile Lys Gln Tyr Arg Asp Tyr Lys Phe 
        35                  40                  45              


Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn Asp Thr 
    50                  55                  60                  


Leu Tyr Ser Thr Arg Met Lys Asp Glu His Asp Tyr Ile Val Gln Thr 
65                  70                  75                  80  


Ile Thr Asp Ile Tyr Gly Lys Asp Asn Thr Asn Leu Lys Lys Gln Phe 
                85                  90                  95      


Asn Lys Asn Pro Glu Lys Phe Leu Met Tyr Gln Asn Asp Pro Lys Thr 
            100                 105                 110         


Phe Glu Lys Leu Ser Ile Ile Met Lys Gln Tyr Ser Asp Glu Lys Asn 
        115                 120                 125             


Pro Leu Ala Lys Tyr Tyr Glu Glu Thr Gly Glu Tyr Leu Thr Lys Tyr 
    130                 135                 140                 


Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Lys Ile Lys Leu Leu Gly 
145                 150                 155                 160 


Asn Lys Val Gly Asn His Leu Asp Val Thr Asn Lys Tyr Glu Asn Ser 
                165                 170                 175     


Thr Lys Lys Leu Val Lys Leu Ser Ile Lys 
            180                 185     


<210>  108
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 11 from 12 mini-domain library

<400>  108

Arg Asn Ile Asn Lys Val Leu Asp Ala Pro Ser Lys Glu Val Asp Lys 
1               5                   10                  15      


Lys Arg Val Thr Val Gln Ser Glu Asp Glu Tyr Asn Gln Ile Phe Glu 
            20                  25                  30          


Asp Thr Gln Lys Ala Gln Ala Ile Lys Lys Phe Glu Ile Arg Lys Phe 
        35                  40                  45              


Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn Asp Thr 
    50                  55                  60                  


Leu Tyr Ser Thr Arg Asn Ile Asp Gly Ile Glu Tyr Val Val Glu Ser 
65                  70                  75                  80  


Ile Lys Asp Ile Tyr Ser Val Asn Asn Asp Lys Val Lys Thr Lys Phe 
                85                  90                  95      


Lys Lys Asp Pro His Arg Leu Leu Met Tyr Arg Asn Asp Pro Gln Thr 
            100                 105                 110         


Phe Glu Lys Phe Glu Lys Val Phe Lys Gln Tyr Glu Ser Glu Lys Asn 
        115                 120                 125             


Pro Phe Ala Lys Tyr Tyr Glu Glu Thr Gly Glu Lys Ile Arg Lys Phe 
    130                 135                 140                 


Ser Lys Thr Gly Gln Gly Pro Tyr Ile Asn Lys Ile Lys Tyr Leu Arg 
145                 150                 155                 160 


Glu Arg Leu Gly Arg His Cys Asp Val Thr Asn Lys Tyr Ile Asn Ser 
                165                 170                 175     


Arg Asn Lys Ile Val Gln Leu Lys 
            180                 


<210>  109
<211>  183
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 11 from 12 mini-domain library

<400>  109

Lys Glu Ile Lys Asp Val Ser Asp Leu Ala Gly Asp Glu Arg Asn Ser 
1               5                   10                  15      


Asn Val Lys Asp Glu Asp Gln Tyr Glu Glu Val Phe Gly Gly Tyr Phe 
            20                  25                  30          


Lys Ile Glu Asp Ile Lys Lys Tyr Lys Ile Lys Lys Phe Ser His Arg 
        35                  40                  45              


Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn Asp Thr Ile Tyr Ser 
    50                  55                  60                  


Thr Arg Val Lys Asp Asp Lys Arg Tyr Leu Ile Asn Thr Leu Lys Asn 
65                  70                  75                  80  


Leu Tyr Asp Lys Ser Asn Gly Asp Leu Lys Glu Arg Met Gln Lys Asp 
                85                  90                  95      


Pro Glu Ser Leu Leu Met Tyr His His Asp Pro Gln Thr Phe Glu Lys 
            100                 105                 110         


Leu Lys Ile Val Met Ser Gln Tyr Glu Asn Glu Lys Asn Pro Leu Ala 
        115                 120                 125             


Lys Tyr Phe Glu Glu Thr Gly Gln Tyr Leu Thr Lys Tyr Ala Lys His 
    130                 135                 140                 


Asp Asn Gly Pro Ala Ile His Lys Ile Lys Tyr Tyr Gly Asn Lys Leu 
145                 150                 155                 160 


Val Glu His Leu Asp Ile Thr Lys Asn Tyr His Asn Pro Gln Asn Lys 
                165                 170                 175     


Val Val Gln Leu Ser Gln Lys 
            180             


<210>  110
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus lugdunensis mini-domain 12 from 12 mini-domain 
       library

<400>  110

Pro Tyr Arg Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile 
1               5                   10                  15      


Thr Ile Ser Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile 
            20                  25                  30          


Pro Glu Gln Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys 
        35                  40                  45              


Asn Ala Lys Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
    50                  55                  60                  


Asp Gly Glu Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn 
65                  70                  75                  80  


Met Ile Glu Leu Asp Leu Pro Asp Ile Arg Tyr Lys Glu Tyr Cys Glu 
                85                  90                  95      


Leu Asn Asn Ile Lys Gly Glu Pro Arg Ile Lys Lys Thr Ile Gly Lys 
            100                 105                 110         


Lys Val Asn Ser Ile Glu Lys Leu Thr Thr Asp Val Leu Gly Asn Val 
        115                 120                 125             


Phe Thr Asn Thr Gln Tyr Thr Lys Pro Gln Leu Leu Phe Lys Arg Gly 
    130                 135                 140                 


Asn 
145 


<210>  111
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus pasteuri mini-domain 12 from 12 mini-domain 
       library

<400>  111

Asn Tyr Arg Phe Asp Val Tyr Leu Thr Glu Lys Gly Tyr Lys Phe Val 
1               5                   10                  15      


Thr Ile Ala Tyr Leu Asn Val Phe Lys Lys Asp Asn Tyr Tyr Tyr Ile 
            20                  25                  30          


Pro Lys Asp Lys Tyr Gln Glu Leu Lys Glu Lys Lys Lys Ile Lys Asp 
        35                  40                  45              


Thr Asp Gln Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu 
    50                  55                  60                  


Asn Gly Asp Leu Tyr Lys Ile Ile Gly Val Asn Ser Asp Asp Arg Asn 
65                  70                  75                  80  


Ile Ile Glu Leu Asp Tyr Tyr Asp Ile Lys Tyr Lys Asp Tyr Cys Glu 
                85                  90                  95      


Ile Asn Asn Ile Lys Gly Glu Pro Arg Ile Lys Lys Thr Ile Gly Lys 
            100                 105                 110         


Lys Thr Glu Ser Ile Glu Lys Phe Thr Thr Asp Val Leu Gly Asn Leu 
        115                 120                 125             


Tyr Leu His Ser Thr Glu Lys Ala Pro Gln Leu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Leu 
145 


<210>  112
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus hyicus mini-domain 12 from 12 mini-domain library

<400>  112

Ile Tyr Ser Tyr Arg Phe Asp Ile Tyr Gln Tyr Gly Asn Asn Tyr Lys 
1               5                   10                  15      


Met Ile Thr Ile Ser Tyr Ile Asp Leu Glu Gln Lys Ser Asn Tyr Tyr 
            20                  25                  30          


Tyr Ile Ser Arg Glu Lys Tyr Glu Gln Lys Lys Lys Asp Lys Gln Ile 
        35                  40                  45              


Asp Asp Ser Tyr Lys Phe Ile Gly Ser Phe Tyr Lys Asn Asp Ile Ile 
    50                  55                  60                  


Asn Tyr Asn Gly Glu Met Tyr Arg Val Ile Gly Val Asn Asp Ser Glu 
65                  70                  75                  80  


Lys Asn Lys Ile Gln Leu Asp Met Ile Asp Ile Ser Ile Lys Asp Tyr 
                85                  90                  95      


Met Glu Leu Asn Asn Ile Lys Lys Thr Gly Val Ile Tyr Lys Thr Ile 
            100                 105                 110         


Gly Lys Ser Thr Thr His Ile Glu Lys Tyr Thr Thr Asp Ile Leu Gly 
        115                 120                 125             


Asn Leu Tyr Lys Ala Ala Pro Pro Lys Lys Pro Gln Leu Ile Phe Lys 
    130                 135                 140                 


<210>  113
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Staphylococcus microti mini-domain 12 from 12 mini-domain library

<400>  113

Ser Phe Arg Phe Asp Val Tyr Gln Thr Asp Lys Gly Tyr Lys Phe Ile 
1               5                   10                  15      


Ser Ile Ala Tyr Leu Thr Leu Lys Asn Glu Lys Asn Tyr Tyr Ala Ile 
            20                  25                  30          


Ser Gln Glu Lys Tyr Asp Gln Leu Lys Ser Glu Lys Lys Ile Ser Asn 
        35                  40                  45              


Asn Ala Val Phe Ile Gly Ser Phe Tyr Thr Ser Asp Ile Ile Glu Ile 
    50                  55                  60                  


Asn Asn Glu Lys Phe Arg Val Ile Gly Val Asn Ser Asp Lys Asn Asn 
65                  70                  75                  80  


Leu Ile Glu Val Asp Arg Ile Asp Ile Arg Gln Lys Glu Phe Ile Glu 
                85                  90                  95      


Leu Glu Glu Glu Lys Lys Asn Asn Arg Ile Lys Val Thr Ile Gly Arg 
            100                 105                 110         


Lys Thr Thr Asn Ile Glu Lys Phe His Thr Asp Ile Leu Gly Asn Met 
        115                 120                 125             


Tyr Lys Ser Lys Arg Pro Lys Ala Pro Gln Leu Val Phe Lys Lys Gly 
    130                 135                 140                 


<210>  114
<211>  104
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNAVEGFA

<400>  114
ggacccccuc caccccgccu cguuuuagua cucuggaaac agaaucuacu gaaacaagac       60

aauaugucgu guuuauccca ucaauuuauu ggugggauuu uuuu                       104


<210>  115
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  ATTO647N oligonucleotide with CGGGCGC-PAM

<400>  115
accccctcca ccccgcctcc gggcgcg                                           27


<210>  116
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Biotinylated oligonucleotide with CGGGCGC-PAM

<400>  116
gcgcgcgccc ggaggcgggg tggagggggt cgg                                    33


<210>  117
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  BFP targeting guide RNA

<400>  117
gggucagggu ggucacgagg                                                   20


<210>  118
<211>  2188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  pCas606

<400>  118
ccactgtaga agagcaaatg ccacctgacg tctaagaaat tcgcgttaaa tttttgttaa       60

atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa atcaaaagaa      120

tagaccgaga tagggttgag tggccgctac actagggcgc gtctaatacg actcactata      180

ggaccccctc caccccgcct cgttttagta ctctggaaac agaatctact gaaacaagac      240

aatatgtcgt gtttatccca tcaatttatt ggtgggattt ttttctagca taaccccttg      300

gggcctctaa acgggtcttg aggggttttt tgtcactgcc cgctttccag tcgggaaacc      360

tgtcgtgcca gctgcattaa tgaatcgttc gtcagaactg cttacgcggt ttgtcactcg      420

gtcgctacgc tccgggcgtg agactgcggc gggcgctgcg gacacataca aagttaccca      480

cagattccgt ggataagcag gggactaaca tgtgaggcaa aacagcaggg ccgcgccggt      540

ggcgtttttc cataggctcc gccctcctgc cagagttcac ataaacagac gcttttccgg      600

tgcatctgtg ggagccgtga ggctcaacca tgaatctgac agtacgggcg aaacccgaca      660

ggacttaaag atccccaccg tttccggcgg gtcgctccct cttgcgctct cctgttccga      720

ccctgccgtt taccggatac ctgttccgcc tttctccctt acgggaagtg tggcgctttc      780

tcatagctca cacactggta tctcggctcg gtgtaggtcg ttcgctccaa gctgggctgt      840

aagcaagaac tccccgttca gcccgactgc tgcgccttat ccggtaactg ttcacttgag      900

tccaacccgg aaaagcacgg taaaacgcca ctggcagcag ccattggtaa ctgggagttc      960

gcagaggatt tgtttagcta aacacgcggt tgctcttgaa gtgtgcgcca aagtccggct     1020

acactggaag gacagatttg gttgctgtgc tctgcgaaag ccagttacca cggttaagca     1080

gttccccaac tgacttaacc ttcgatcaaa ccacctcccc aggtggtttt ttcgtttaca     1140

gggcaaaaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctact     1200

gaaccgctca atctaaagta tatatgagta aacttggtct gacagttatt agaaaaactc     1260

atcgagcatc aaatgaaact gcaatttatt catatcagga ttatcaatac catatttttg     1320

aaaaagccgt ttctgtaatg aaggagaaaa ctcaccgagg cagttccata ggatggcaag     1380

atcctggtat cggtctgcga ttccgactcg tccaacatca atacaaccta ttaatttccc     1440

ctcgtcaaaa ataaggttat caagtgagaa atcaccatga gtgacgactg aatccggtga     1500

gaatggcaaa agtttatgca tttctttcca gacttgttca acaggccagc cattacgctc     1560

gtcatcaaaa tcactcgcat caaccaaacc gttattcatt cgtgattgcg cctgagcgag     1620

acgaaatacg cgatcgctgt taaaaggaca attacaaaca ggaatcgaat gcaaccggcg     1680

caggaacact gccagcgcat caacaatatt ttcacctgaa tcaggatatt cttctaatac     1740

ctggaatgct gttttcccgg ggatcgcagt ggtgagtaac catgcatcat caggagtacg     1800

gataaaatgc ttgatggtcg gaagaggcat aaattccgtc agccagttta gtctgaccat     1860

ctcatctgta acatcattgg caacgctacc tttgccatgt ttcagaaaca actctggcgc     1920

atcgggcttc ccatacaatc gatagattgt cgcacctgat tgcccgacat tatcgcgagc     1980

ccatttatac ccatataaat cagcatccat gttggaattt aatcgcggcc tagagcaaga     2040

cgtttcccgt tgaatatggc tcatactctt cctttttcaa tattattgaa gcatttatca     2100

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     2160

ggttccgcgc acatttcccc gaaaagtg                                        2188


<210>  119
<211>  9489
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  pCas634

<400>  119
ccggtgatac cacgatacta tgactgagag tcaacgccat gagcggcctc atttcttatt       60

ctgagttaca acagtccgca ccgctgccgg tagctattga ctatccggct gcactagccc      120

tgcgtcagat ggctctgatc caaggcaaac tgccaaaata tctgctggca ccggaagtca      180

gcgccctgca ccattatgtt ccggatctgc atcgcaggat gctgctggct accctgtgga      240

acacctacat ctgtattaac gaagcgctgg cattgaccct gagtgatttt tctctggtgc      300

cgccctatcc ctttgtgcag cttgccacgc tcaaaggggt ttgaggtcca accgtacgaa      360

aacgtacggt aagaggaaaa ttatcgtctg aaaaatcgat tagtagacaa gaaagtccgt      420

taagtgccaa ttttcgatta aaaagacacc gttttgatgg cgttttccaa tgtacattat      480

gtttcgatat atcagacagt tacttcacta acgtacgttt tcgttctatt ggccttcaga      540

ccccatatcc ttaatgtcct ttatttgctg gggttatcag atccccccga cacgtttaat      600

taatgctttc tccgccggag atcgacgcac agcgttctgt gctctatgat gttatttctt      660

aataatcatc caggtattct ctttatcacc atacgtagtg cgagtgtcca ccttaacgca      720

gggctttccg tcacagcgcg atatgtcagc cagcggggct ttcttttgcc agaccgcttc      780

catcctctgc atttcagcaa tctggctata cccgtcattc ataaaccacg taaatgccgt      840

cacgcaggaa gccaggacga agaatatcgt cagtacaaga taaatcgcgg atttccacgt      900

atagcgtgac atctcacgac gcatttcatg gatcatcgct ttcgccgtat cggcagcctg      960

attcagcgct tctgtcgccg gtttctgctg tgctaatccg gcttgtttca gttctttctc     1020

aacctgagtg agcgcggaac tcaccgattt cctgacggtg tcagtcatat taccggacgc     1080

gctgtccagc tcacgaatga ccctgctcag cgtttcactt tgctgctgta attgtgatga     1140

ggcggcctga aactgttctg tcagagaagt aacacgcttt tccagcgcct gatgatgccc     1200

gataagggcg gcaatttgtt taatttcgtc gctcatacaa aatcctgcct atcgtgagaa     1260

tgaccagcct ttatccggct tctgtcgtat ctgttcggcg agtcgctgtc gttctttctc     1320

ctgctgacgc tgtttttccg ccagacgttc gcgctctctc tgcctttcca tctcctgatg     1380

tatcccctgg aactccgcca tcgcatcgtt aacaagggac tgaagatcga tttcttcctg     1440

tatatccttc atggcatcac tgaccagtgc gttcagcttg tcaggctctt tttcaaaatc     1500

aaacgttctg ccggaatggg attcctgctc aggctctgac ttcagctcct gttttagcgt     1560

cagagtatcc ctctcgctga gggcttcccg taacgaggta gtcacgtcaa ttacgctgtc     1620

acgttcatca cgggactgct gcacctgcct ttcagcctcc ctgcgctcaa gaatggcctg     1680

tagctgctca gtatcgaatc gctgaacctg acccgcgccc agatgccgct caggctcacg     1740

gtcaatgccc tgcgccttca gggaacggga atcaacccgg tcagcgtgct gataccgttc     1800

aaggtgctta ttctggaggt cagcccagcg ttccctctgg gcaacaaggt attctttgcg     1860

ttcggtcggt gtttccccga aacgtgcctt ttttgcgcca ccgcgctccg gctctttggt     1920

gttagcccgt ttaaaatact gctcagggtc acggtgaata ccgtcattaa tgcgttcaga     1980

gaacatgata tgggcgtggg gctgctcgcc accggctatc gctgctttcg gattatggat     2040

agcgaactga taggcatggc ggtcgccaat ttcctgttgg acaaaatcgc ggacaagctc     2100

aagacgttgt tcgggtttta actcacgcgg cagggcaatc tcgatttcac ggtaggtaca     2160

gccgttggca cgttcagacg tgtcagcggc tttccagaac tcggacggtt tatgcgctgc     2220

ccacgccggc atattgccgg actccttgtg ctcaaggtcg gagtcttttt cacgggcata     2280

ctttccctca cgcgcaatat aatcggcatg aggagaggca ctgccttttc cgccggtttt     2340

tacgctgaga tgataggatg ccatcgtgtt ttatcccgct gaaggcgcgc accgtttctg     2400

aacgaagtga agaaacgtct aagtgcgccc tgataaataa aagagttatc agggattgta     2460

gtgggatttg acctcctctg ccatcactga gcataatcat tccgttagca ttcaggaggt     2520

aaacagcatg aataaaagcg aaaaacagga acaatgggca gcagaaagag tgcagtatat     2580

tcgcggctta aagtcgccga atgagcaaca gaaacttatg ctgatactga cggataaagc     2640

agataaaaca gcacaggata tcaaaacgct gtccctgctg atgaaggctg aacaggcagc     2700

agagaaagcg caggaagcca gagcgaaagt catgaacctg atacaggcag aaaagcgagc     2760

cgaagccaga gccgcccgta aagcccgtga ccatgctctg taccagtctg ccggattgct     2820

tatcctggcg ggtctggttg acagtaagac gggtaagcct gttgatgata ccgctgcctt     2880

actgggtgca ttagccagtc tgaatgacct gtcacgggat aatccgaagt ggtcagactg     2940

gaaaatcaga gggcaggaac tgctgaacag caaaaagtca gatagcacca catagcagac     3000

ccgccataaa acgccctgag aagcccgtga cgggcttttc ttgtattatg ggtagtttcc     3060

ttgcatgaat ccataaaagg cgcctgtagt gccatttacc cccattcact gccagagccg     3120

tgagcgcagc gaactgaatg tcacgaaaaa gacagcgact caggtgcctg atggtcggag     3180

acaaaaggaa tattcagcga tttgcccgag cttgcgaggg tgctacttaa gcctttaggg     3240

ttttaaggtc tgttttgtag aggagcaaac agcgtttgcg acatcctttt gtaatactgc     3300

ggaactgact aaagtagtga gttatacaca gggctgggat ctattctttt tatctttttt     3360

tattctttct ttattctata aattataacc acttgaatat aaacaaaaaa aacacacaaa     3420

ggtctagcgg aatttacaga gggtctagca gaatttacaa gttttccagc aaaggtctag     3480

cagaatttac agatacccac aactcaaagg aaaaggacta gtaattatca ttgactagcc     3540

catctcaatt ggtatagtga ttaaaatcac ctagaccaat tgagatgtat gtctgaatta     3600

gttgttttca aagcaaatga actagcgatt agtcgctatg acttaacgga gcatgaaacc     3660

aagctaattt tatgctgtgt ggcactactc aaccccacga ttgaaaaccc tacaaggaaa     3720

gaacggacgg tatcgttcac ttataaccaa tacgctcaga tgatgaacat cagtagggaa     3780

aatgcttatg gtgtattagc taaagcaacc agagagctga tgacgagaac tgtggaaatc     3840

aggaatcctt tggttaaagg ctttgagatt ttccagtgga caaactatgc caagttctca     3900

agcgaaaaat tagaattagt ttttagtgaa gagatattgc cttatctttt ccagttaaaa     3960

aaattcataa aatataatct ggaacatgtt aagtcttttg aaaacaaata ctctatgagg     4020

atttatgagt ggttattaaa agaactaaca caaaagaaaa ctcacaaggc aaatatagag     4080

attagccttg atgaatttaa gttcatgtta atgcttgaaa ataactacca tgagtttaaa     4140

aggcttaacc aatgggtttt gaaaccaata agtaaagatt taaacactta cagcaatatg     4200

aaattggtgg ttgataagcg aggccgcccg actgatacgt tgattttcca agttgaacta     4260

gatagacaaa tggatctcgt aaccgaactt gagaacaacc agataaaaat gaatggtgac     4320

aaaataccaa caaccattac atcagattcc tacctacata acggactaag aaaaacacta     4380

cacgatgctt taactgcaaa aattcagctc accagttttg aggcaaaatt tttgagtgac     4440

atgcaaagta agtatgatct caatggttcg ttctcatggc tcacgcaaaa acaacgaacc     4500

acactagaga acatactggc taaatacgga aggatctgag gttcttatgg ctcttgtatc     4560

tatcagtgaa gcatcaagac taacaaacaa aagtagaaca actgttcacc gttacatatc     4620

aaagggaaaa ctgtccatat gcacagatga aaacggtgta aaaaagatag atacatcaga     4680

gcttttacga gtttttggtg cattcaaagc tgttcaccat gaacagatcg acaatgtaac     4740

agatgaacag catgtaacac ctaatagaac aggtgaaacc agtaaaacaa agcaactaga     4800

acatgaaatt gaacacctga gacaacttgt tacagctcaa cagtcacaca tagacagcct     4860

gaaacaggcg atgctgctta tcgaatcaaa gctgccgaca acacgggagc cagtgacgcc     4920

tcccgtgggg aaaaaatcat ggcaattctg gaagaaatag cgctttcagc cggcaaaccg     4980

gctgaagccg gatctgcgat tctgataaca aactagcaac accagaacag cccgtttgcg     5040

ggcagcaaaa cccgtacttt tggacgttcc ggcggttttt tgtggcgagt ggtgttcggg     5100

cggtgcgcgc aagatccatt atgttaaacg ggcgagttta catctcaaaa ccgcccgctt     5160

aacaccatca gaaatcctca gcgcgatttt aagcaccaac ccccccccgt aacacccaaa     5220

tccatactga aagtggcttt gttgaataaa tcgaactttt gctgagttga aggatcagat     5280

cacgcatcct cccgacaaca cagaccattc cgtggcaaag caaaagttca gaatcaccaa     5340

ctggtccacc tacaacaaag ctctcatcaa ccgtggctcc ctcactttct ggctggatga     5400

tgaggcgatt caggcctggt atgagtcggc aacaccttca tcacgaggaa ggccccagcg     5460

ctattctgat ctcgccatca ccaccgttct ggtgattaaa cgcgtattcc ggctgaccct     5520

gcgggctgcg cagggtttta ttgattccat ttttgccctg atgaacgttc cgttgcgctg     5580

cccggattac accagtgtca gtaagcgggc aaagtcggtt aatgtcagtt tcaaaacgtc     5640

cacccggggt gaaatcgcac acctggtgat tgattccacc gggctgaagg tctttggtga     5700

aggcgaatgg aaagtcagaa agcacggcaa agagcgccgt cgtatctggc gaaagttgca     5760

tcttgctgtt gacagcaaca cacatgaagt tgtctgtgca gacctgtcgc tgaataacgt     5820

cacggactca gaagccttcc cgggccttat ccggcagact cacagaaaaa tcagggcagc     5880

cgcggcagac ggggcttacg atacccggct ctgtcacgat gaactgcgcc gcaaaaaaat     5940

cagcgcgctt attcctcccc gaaaaggtgc gggttactgg cccggtgaat atgcagaccg     6000

taaccgtgca gtggctaatc agcgaatgac cgggagtaat gcgcggtgga aatggacaac     6060

agattacaac cgtcgctcga tagcggaaac ggcgatgtac cgggtaaaac agctgttcgg     6120

gggttcactg acgctgcgtg actacgatgg tcaggttgcg gaggctatgg ccctggtacg     6180

agcgctgaac aaaatgacga aagcaggtat gcctgaaagc gtgcgtattg cctgaaaaca     6240

caacccgcta cgggggagac ttacccgaaa tctgatttat tcaacaaagc cgggtgtggt     6300

gaactacaaa gcagacccgt tgaggttatc agttcgatgc acaatcagca gcgcataaaa     6360

tatgcacaag aacaggagca cccttcgcat taagctgtgg tggtaacaag tagtgccggg     6420

ctaccatcag cgagcatgat gcgctcccac agcattcgcc ttggcagtat ggaagttcct     6480

cgctccagtt cgggccggta tccacctcga gctttctacg gggtctgacg ctcagtggaa     6540

cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat     6600

ccttttcgac cgaataaata cctgtgacgg aagatcactt cgcagaataa ataaatcctg     6660

gtgtccctgt tgataccggg aagccctggg ccaacttttg gcgaaaatga gacgttgatc     6720

ggcacgtaag aggttccaac tttcaccata atgaaataag atcactaccg ggcgtatttt     6780

ttgagttgtc gagattttca ggagctaagg aagctaaaat ggagaaaaaa atcactggat     6840

ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca tttcagtcag     6900

ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt ttaaagaccg     6960

taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc cgcctgatga     7020

atgctcatcc ggaattacgt atggcaatga aagacggtga gctggtgata tgggatagtg     7080

ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg ctctggagtg     7140

aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg gcgtgttacg     7200

gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc gtctcagcca     7260

atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac aacttcttcg     7320

cccccgtttt caccttgggc aaatattata cgcaaggcga caaggtgctg atgccgctgg     7380

cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg cttaatgaat     7440

tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc agttattggt     7500

gcccttaaac gcctggttgc tacgcctgaa taagtgataa taagcggatg aatggcagaa     7560

attcgaaagc aaattcgacc cggtcgtcgg ttcagggcag ggtcgttaaa tagccgctta     7620

tgtctattgc tggtttaccg gattattgac taccggaagc agtgtgaccg tgtgcttctc     7680

aaatgcctga ggccagtttg ctcaggctct ccccgtggag gtaataattg acgatatgat     7740

cctttttttc tgatcaaaag tgctccatgg aattatgaca acttgacggc tacatcattc     7800

actttttctt cacaaccggc acggaactcg ctcgggctgg ccccggtgca ttttttaaat     7860

acccgcgaga aatagagttg atcgtcaaaa ccaacattgc gaccgacggt ggcgataggc     7920

atccgggtgg tgctcaaaag cagcttcgcc tggctgatac gttggtcctc gcgccagctt     7980

aagacgctaa tccctaactg ctggcggaaa agatgtgaca gacgcgacgg cgacaagcaa     8040

acatgctgtg cgacgctggc gatatcaaaa ttgctgtctg ccaggtgatc gctgatgtac     8100

tgacaagcct cgcgtacccg attatccatc ggtggatgga gcgactcgtt aatcgcttcc     8160

atgcgccgca gtaacaattg ctcaagcaga tttatcgcca gcagctccga atagcgccct     8220

tccccttgcc cggcgttaat gatttgccca aacaggtcgc tgaaatgcgg ctggtgcgct     8280

tcatccgggc gaaagaaccc cgtattggca aatattgacg gccagttaag ccattcatgc     8340

cagtaggcgc gcggacgaaa gtaaacccac tggtgatacc attcgcgagc ctccggatga     8400

cgaccgtagt gatgaatctc tcctggcggg aacagcaaaa tatcacccgg tcggcaaaca     8460

aattctcgtc cctgattttt caccaccccc tgaccgcgaa tggtgagatt gagaatataa     8520

cctttcattc ccagcggtcg gtcgataaaa aaatcgagat aaccgttggc ctcaatcggc     8580

gttaaacccg ccaccagatg ggcattaaac gagtatcccg gcagcagggg atcattttgc     8640

gcttcagcca tacttttcat actcccgcca ttcagagaag aaaccaattg tccatattgc     8700

atcagacatt gccgtcactg cgtcttttac tggctcttct cgctaaccaa accggaaacc     8760

ccgcttatta aaagcattct gtaacaaagc gggaccaaag ccatgacaaa aacgcgtaac     8820

aaaagtgtct ataatcacgg cagaaaagtc cacattgatt atttgcacgg cgtcacactt     8880

tgctatgcca tagcattttt atccataaga ttagcggatc ctacctgacg ctttttatcg     8940

caactctcta ctgtcgtgcg caacgcgtga catcgactag gaggcctttc tatgcagttc     9000

aaagtgtata cctataaacg cgaaagccgt tatcgtctgt ttgttgatgt tcagagcgat     9060

attattgata caccgggtcg tcgtatggtt attccgctgg caagcgcacg tctgctgagc     9120

gataaagtta gccgtgaact gtatccggtt gttcatattg gtgatgaaag ctggcgtatg     9180

atgaccaccg atatggcaag cgttccggtt agcgttattg gtgaagaagt tgcagatctg     9240

agccatcgtg aaaacgatat caaaaatgcc atcaacctga tgttttgggg catcttatag     9300

gaccccctcc accccgcctc gcgggcagtt tgcctggcgg cagtagcgcg gtggtcccac     9360

ctgaccccat gccgaactca gaagtgaaac gccgtagcgc cgatggtagt gtgggctctc     9420

cccatgcgag agtagggaac tgccaggcat caaataaaac gaaaggctca gtcgaaagac     9480

tgggcctta                                                             9489


<210>  120
<211>  6740
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  pCas81

<400>  120
ggtggaagcg gaggcagcgg gggatcaggc catcatcatc accatcatta atgaacgggt       60

cttgaggggt tttttggact tttgcgtatt gggcgctctt ccgcttcctc gctcactgac      120

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata      180

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa      240

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct      300

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa      360

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg      420

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca      480

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa      540

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg      600

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg      660

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg      720

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc      780

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag      840

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac      900

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc      960

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     1020

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     1080

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag     1140

ggcttaccat ctggccccag tgctgcaatg ataccgcgag atccacgctc accggctcca     1200

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact     1260

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca     1320

gttaatagtt tgcgcaacgt tgttgccatt gctgcaggca tcgtggtgtc acgctcgtcg     1380

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc     1440

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg     1500

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca     1560

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt     1620

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc     1680

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc     1740

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca     1800

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa     1860

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat     1920

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa     1980

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccactcct cttgctgtga     2040

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgaggc     2100

agcagatcaa ttcgcgcgcg aaggcgaagc ggcatgcatt tacgttgaca ccatcgaatg     2160

gtgcaaaacc tttcgcggta tggcatgata gcgcccggaa gagagtcaat tcagggtggt     2220

gaatgtgaaa ccagtaacgt tatacgatgt cgcagagtat gccggtgtct cttatcagac     2280

cgtttcccgc gtggtgaacc aggccagcca cgtttctgcg aaaacgcggg aaaaagtgga     2340

agcggcgatg gcggagctga attacattcc caaccgcgtg gcacaacaac tggcgggcaa     2400

acagtcgttg ctgattggcg ttgccacctc cagtctggcc ctgcacgcgc cgtcgcaaat     2460

tgtcgcggcg attaaatctc gcgccgatca actgggtgcc agcgtggtgg tgtcgatggt     2520

agaacgaagc ggcgtcgaag cctgtaaagc ggcggtgcac aatcttctcg cgcaacgcgt     2580

cagtgggctg atcattaact atccgctgga tgaccaggat gccattgctg tggaagctgc     2640

ctgcactaat gttccggcgt tatttcttga tgtctctgac cagacaccca tcaacagtat     2700

tattttctcc catgaagatg gtacgcgact gggcgtggag catctggtcg cattgggtca     2760

ccagcaaatc gcgctgttag cgggcccatt aagttctgtc tcggcgcgtc tgcgtctggc     2820

tggctggcat aaatatctca ctcgcaatca aattcagccg atagcggaac gggaaggcga     2880

ctggagtgcc atgtccggtt ttcaacaaac catgcaaatg ctgaatgagg gcatcgttcc     2940

cactgcgatg ctggttgcca acgatcagat ggcgctgggc gcaatgcgcg ccattaccga     3000

gtccgggctg cgcgttggtg cggatatctc ggtagtggga tacgacgata ccgaagatag     3060

ctcatgttat atcccgccgt taaccaccat caaacaggat tttcgcctgc tggggcaaac     3120

cagcgtggac cgcttgctgc aactctctca gggccaggcg gtgaagggca atcagctgtt     3180

gcccgtctca ctggtgaaaa gaaaaaccac cctggcgccc aatacgcaaa ccgcctctcc     3240

ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg     3300

gcagtgagcg caatattctg aaatgagctg ttgacaatta atcatccggc tcgtataatg     3360

tgtggaattg tgagcggata acaattttca cacaggaaac agaattctag cattgtgagc     3420

ggataacaat tcccctctag aaataatttt gtttaacttt aagaaggaga tataccatga     3480

aacgtccggc agcaaccaaa aaagcaggtc aggccaagaa aaaaaaaggt ggtggttcag     3540

gtaaccagaa atttatcctg ggtctggata ttggtattac cagcgttggt tatggcctga     3600

ttgattacga aaccaaaaac attattgatg ccggtgttcg tctgtttccg gaagcaaatg     3660

ttgaaaataa tgaaggtcgt cgtagcaaac gtggtagccg tcgtctgaaa cgtcgtcgta     3720

ttcatcgtct ggaacgtgtt aaaaaactgc tggaagatta taacctgctg gatcagagcc     3780

agattccgca gagcaccaat ccgtatgcaa ttcgtgttaa aggtctgagc gaagcactga     3840

gcaaagatga actggttatt gcactgctgc atattgcaaa acgccgtggc attcataaaa     3900

tcgatgtgat tgatagcaat gacgatgtgg gtaatgaact gagcaccaaa gaacagctga     3960

acaaaaatag caaactgctg aaagacaaat tcgtgtgtca gattcagctg gaacgtatga     4020

atgaaggcca ggttcgtggt gaaaagaatc gctttaaaac cgcagacatc atcaaagaaa     4080

ttatccagct gctgaacgtg cagaaaaact tccatcagct ggatgaaaac ttcatcaaca     4140

aatacatcga gctggttgaa atgcgtcgcg aatattttga aggtccgggt aaaggtagcc     4200

cgtatggttg ggaaggtgat ccgaaagcat ggtatgaaac cctgatgggt cattgtacct     4260

attttccgga tgaactgcgt agcgttaaat atgcctatag cgcagacctg tttaatgcac     4320

tgaatgatct gaataacctg gtgattcagc gtgatggtct gagcaaactg gaatatcatg     4380

agaaatatca catcatcgaa aacgtgttca aacagaagaa gaaaccgacc ctgaaacaaa     4440

tcgccaacga aattaatgtg aacccggaag atattaaagg ctaccgtatt accaaaagcg     4500

gtaaaccgca gttcaccgaa tttaaactgt atcacgatct gaaaagcgtg ctgtttgatc     4560

agagcattct ggaaaatgaa gatgtgctgg accagattgc agaaattctg accatttatc     4620

aggacaaaga cagcatcaaa agcaaactga ccgaactgga tattctgctg aatgaagaag     4680

ataaagagaa cattgcacag ctgaccggtt ataccggcac ccatcgtctg agcctgaaat     4740

gtattcgtct ggtactggaa gaacagtggt atagcagccg taatcagatg gaaatcttta     4800

cccatctgaa cattaaaccg aagaaaatca atctgaccgc agccaacaaa attccgaaag     4860

ccatgattga tgagtttatt ctgagtccgg ttgtgaaacg tacctttggt caggcaatta     4920

acctgatcaa caaaatcatt gaaaaatatg gcgtgcctga ggatatcatt attgaactgg     4980

cacgtgaaaa caacagcaaa gataaacaga aattcatcaa cgagatgcag aagaagaacg     5040

aaaatacccg caaacggatt aacgagatca ttggcaaata tggtaatcag aatgccaaac     5100

gcctggtgga aaaaattcgt ctgcatgatg aacaagaggg caaatgtctg tatagcctgg     5160

aaagcattcc tctggaagat ctgctgaaca atccgaatca ttatgaagtg gatcacatta     5220

ttccgcgtag cgtgagcttt gataattcct atcataataa agtgctggtg aaacagagcg     5280

aaaactccaa aaaatccaac ctgacaccgt atcagtattt caatagcggc aaatccaaac     5340

tgagctacaa ccagtttaaa cagcatattc tgaacctgag caaaagccag gatcgcatca     5400

gcaagaagaa gaaggagtac ctgctggaag aacgcgacat caacaaattt gaagtgcaga     5460

aagaatttat caaccgcaac ctggttgata cccgttatgc aacccgtgaa ctgaccaatt     5520

atctgaaagc atatttcagc gccaacaaca tgaacgtgaa agtgaaaacg attaacggca     5580

gctttaccga ttatctgcgt aaagtgtgga aattcaaaaa agaacgcaac cacggctata     5640

aacatcatgc cgaagatgcc ctgattattg caaatgcaga tttcctgttt aaagaaaaca     5700

aaaaactgaa agccgtcaac agcgtgctgg aaaaaccgga aattgagaca aaacagctgg     5760

acattcaggt tgatagcgaa gataattaca gcgaaatgtt tatcatcccg aaacaggtgc     5820

aggatatcaa agattttcgc aacttcaaat atagccaccg cgttgacaaa aaacctaatc     5880

gtcagctgat taacgatacc ctgtatagca cccgcaaaaa agataacagc acctatattg     5940

tgcagaccat taaagacatc tacgccaaag ataataccac cctgaaaaaa cagttcgaca     6000

aaagcccaga aaaatttctg atgtatcagc atgatccgcg taccttcgaa aaactggaag     6060

ttattatgaa acagtatgcc aacgagaaaa atccgctggc caaatatcac gaagaaaccg     6120

gtgaatatct gaccaaatat tccaagaaga acaacggtcc gatcgttaaa tccctgaaat     6180

atatcggtaa taaactgggc agccatctgg atgttaccca tcagtttaaa agctccacaa     6240

agaagctggt taaactgtcc atcaaaccgt atcgctttga tgtgtatctg accgacaaag     6300

gctataaatt cattaccatc agctatctgg acgtgctgaa aaaagacaac tattattata     6360

tcccggaaca gaaatatgat aaactgaaac tgggtaaagc catcgataaa aacgccaaat     6420

ttatcgccag cttctacaaa aacgacctga ttaaactgga tggcgagatc tataaaatca     6480

tcggtgttaa tagcgacacc cgcaatatga ttgagctgga tctgccggat attcgctata     6540

aagaatattg cgaactgaac aacattaaag gcgaaccgcg tatcaaaaag accatcggca     6600

aaaaagtgaa tagcatcgag aaactgacca ccgatgttct gggtaatgtg tttaccaata     6660

cccagtatac caaacctcag ctgctgttca aacgcggtaa tggcggagga tctggccccc     6720

ctaagaaaaa gcggaaggtg                                                 6740


<210>  121
<211>  6740
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  pCas888

<400>  121
tgccacctcc agtctggccc tgcacgcgcc gtcgcaaatt gtcgcggcga ttaaatctcg       60

cgccgatcaa ctgggtgcca gcgtggtggt gtcgatggta gaacgaagcg gcgtcgaagc      120

ctgtaaagcg gcggtgcaca atcttctcgc gcaacgcgtc agtgggctga tcattaacta      180

tccgctggat gaccaggatg ccattgctgt ggaagctgcc tgcactaatg ttccggcgtt      240

atttcttgat gtctctgacc agacacccat caacagtatt attttctccc atgaagatgg      300

tacgcgactg ggcgtggagc atctggtcgc attgggtcac cagcaaatcg cgctgttagc      360

gggcccatta agttctgtct cggcgcgtct gcgtctggct ggctggcata aatatctcac      420

tcgcaatcaa attcagccga tagcggaacg ggaaggcgac tggagtgcca tgtccggttt      480

tcaacaaacc atgcaaatgc tgaatgaggg catcgttccc actgcgatgc tggttgccaa      540

cgatcagatg gcgctgggcg caatgcgcgc cattaccgag tccgggctgc gcgttggtgc      600

ggatatctcg gtagtgggat acgacgatac cgaagatagc tcatgttata tcccgccgtt      660

aaccaccatc aaacaggatt ttcgcctgct ggggcaaacc agcgtggacc gcttgctgca      720

actctctcag ggccaggcgg tgaagggcaa tcagctgttg cccgtctcac tggtgaaaag      780

aaaaaccacc ctggcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt      840

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aatattctga      900

aatgagctgt tgacaattaa tcatccggct cgtataatgt gtggaattgt gagcggataa      960

caattttcac acaggaaaca gaattctagc attgtgagcg gataacaatt cccctctaga     1020

aataattttg tttaacttta agaaggagat ataccatgaa acgtccggca gcaaccaaaa     1080

aagcaggtca ggccaagaaa aaaaaaggtg gtggttcagg caacaactat attctgggtc     1140

tggatattgg tattaccagc gttggttatg gtattgttga tagcgatacc cgtgaaatta     1200

aagatgccgg tgttcgtctg tttccggaag caaatgttga taataatgaa ggtcgtcgta     1260

gcaaacgtgg tgcacgtcgt ctgaaacgtc gtcgtattca tcgtctggat cgtgttaaac     1320

atctgctggc agaatatgat ctgctggatc tgaccaatat tccgaaaagc accaatccgt     1380

atcagacccg tgttaaaggt ctgaatgaaa agctgagcaa agatgaactg gttattgcac     1440

tgctgcatat tgcaaaacgc cgtggcattc ataatgtgaa tgttatgatg gatgataacg     1500

atagcggtaa tgaactgagc accaaagatc agctgaagaa gaatgcaaaa gcactgagcg     1560

ataaatatgt ttgtgaactg cagctggaac gctttgagca ggattataaa gttcgtggtg     1620

aaaagaaccg cttcaaaacc gaagattttg ttcgtgaagc acgtaaactg ctggaaaccc     1680

agagcaaatt tttcgaaatt gatcagacgt tcatcatgcg ctatatcgaa ctgattgaaa     1740

cccgtcgcga atattttgaa ggtccgggta aaggtagccc gtttggttgg gaaggtaata     1800

tcaagaaatg gtttgagcag atgatgggcc actgtaccta ttttccagaa gaactgcgta     1860

gcgtcaaata tagctattca gccgaactgt ttaacgccct gaatgatctg aataatctgg     1920

tgattacccg tgatgaagat gccaaactga attatggtga gaaattccag atcatcgaaa     1980

acgtgttcaa acagaagaaa acaccgaacc tgaaacaaat cgccattgaa attggtgtgc     2040

atgaaaccga aatcaaaggt tatcgtgtga acaaaagcgg caaaccggaa tttacccagt     2100

tcaaactgta tcacgatctg aagaacatct tcaaagaccc gaaatacctg aacgatatcc     2160

agctgatgga taacattgca gaaatcatca ccatttatca ggatgccgaa agcatcatca     2220

aagaactgaa tcagctgccg gaactgctga gcgaacgtga aaaggagaag atcagcgcac     2280

tgagcggtta tagcggcacc catcgtctga gcctgaaatg tattaatctg ctgctggatg     2340

atctgtggga aagcagcctg aatcagatgg aactgttcac aaaactgaat ctgaaaccga     2400

agaaaatcga tctgagccag cagcataaaa ttccgagcaa actggtggat gactttattc     2460

tgagtccggt tgttaaacgt gcatttattc agagtatcca ggtggtgaat gccatcattg     2520

ataaatacgg tctgccggaa gatatcatca ttgaactggc acgtgaaaac aatagtgatg     2580

atcgtcgcaa atttctgaac cagctgcaaa agcagaatga ggaaacccgt aaacaggttg     2640

aaaaggtgct gcgtgaatat ggcaatgata atgccaaacg tatcgtgcag aaaatcaaac     2700

tgcataatat gcaagagggg aaatgtctgt atagcctgaa agatattccg ctggaagatc     2760

tgctgcgtaa tccgcatcat tatgaagtgg atcatattat tccgcgtagc gtggcatttg     2820

ataatagcat gcataataaa gttctggtgc gtgccgatga gaatagcaag aaaggtaatc     2880

gtaccccgta tcagtatctg aatagcagcg aaagcagtct gagctataac gaatttaaac     2940

agcatatcct gaacctgagc aaaaccaaag accgcatcac caagaagaag cgtgaatacc     3000

tgctggaaga acgcgacatc aacaaatttg atgtgcagaa agaattcatc aaccgcaatc     3060

tggttgatac acgttatgca acccgtgaac tgaccagcct gctgaaagca tatttcagcg     3120

caaataacct ggacgtgaaa gtgaaaacga ttaatggcag ctttaccaac tatctgcgta     3180

aagtgtggaa attcgataaa gatcgcaaca aaggctataa acatcatgca gaagatgccc     3240

tgattattgc caatgcagat tttctgttca aacacaacaa gaaactgcgc aacattaaca     3300

aagtgctgga tgcaccgagc aaagaagttg ataagaaacg cgtgacagtt cagagcgaag     3360

atgaatataa ccagattttt gaggataccc agaaagccca ggcaatcaag aaattcgaaa     3420

tccgcaaatt tagccaccgc gtggacaaga aaccgaatcg tcagctgatt aatgataccc     3480

tgtatagcac ccgtaatatc gatggtattg aatatgtggt cgagagcatc aaagatatct     3540

atagcgtgaa caacgataaa gttaaaacca aattcaagaa agacccgcac cgtctgctga     3600

tgtatcgtaa tgatccgcag acctttgaga aattcgagaa agtctttaaa cagtatgaga     3660

gcgagaagaa cccgttcgcc aaatattacg aagaaaccgg tgagaaaatt cgcaaattca     3720

gcaaaaccgg tcagggtccg tatatcaaca aaatcaaata tctgcgtgaa cgcctgggtc     3780

gtcattgtga tgttaccaac aaatatatca atagccgcaa caaaattgtg caactgtcca     3840

tcaaaccgta tcgctttgat gtgtatctga ccgacaaagg ctataaattc attaccatca     3900

gctatctgga cgtgctgaaa aaagacaact attattatat cccggaacag aaatatgata     3960

aactgaaact gggtaaagcc atcgataaaa acgccaaatt tatcgccagc ttctacaaaa     4020

acgacctgat taaactggat ggcgagatct ataaaatcat cggtgttaat agcgacaccc     4080

gcaatatgat tgagctggat ctgccggata ttcgctataa agaatattgc gaactgaaca     4140

acattaaagg cgaaccgcgt atcaaaaaga ccatcggcaa aaaagtgaat agcatcgaga     4200

aactgaccac cgatgttctg ggtaatgtgt ttaccaatac ccagtatacc aaacctcagc     4260

tgctgttcaa acgcggtaat ggcggaggat ctggcccccc taagaaaaag cggaaggtgg     4320

gtggaagcgg aggcagcggg ggatcaggcc atcatcatca ccatcattaa tgaacgggtc     4380

ttgaggggtt ttttggactt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact     4440

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     4500

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     4560

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     4620

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     4680

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     4740

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac     4800

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     4860

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     4920

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     4980

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga     5040

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     5100

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     5160

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     5220

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     5280

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     5340

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     5400

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     5460

gcttaccatc tggccccagt gctgcaatga taccgcgaga tccacgctca ccggctccag     5520

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     5580

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     5640

ttaatagttt gcgcaacgtt gttgccattg ctgcaggcat cgtggtgtca cgctcgtcgt     5700

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     5760

tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     5820

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     5880

ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta     5940

tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca     6000

gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct     6060

taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat     6120

cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa     6180

agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt     6240

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa     6300

ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccactcctc ttgctgtgac     6360

cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgaggca     6420

gcagatcaat tcgcgcgcga aggcgaagcg gcatgcattt acgttgacac catcgaatgg     6480

tgcaaaacct ttcgcggtat ggcatgatag cgcccggaag agagtcaatt cagggtggtg     6540

aatgtgaaac cagtaacgtt atacgatgtc gcagagtatg ccggtgtctc ttatcagacc     6600

gtttcccgcg tggtgaacca ggccagccac gtttctgcga aaacgcggga aaaagtggaa     6660

gcggcgatgg cggagctgaa ttacattccc aaccgcgtgg cacaacaact ggcgggcaaa     6720

cagtcgttgc tgattggcgt                                                 6740


<210>  122
<211>  1431
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  pCas889

<400>  122
cggaacggga aggcgactgg agtgccatgt ccggttttca acaaaccatg caaatgctga       60

atgagggcat cgttcccact gcgatgctgg ttgccaacga tcagatggcg ctgggcgcaa      120

tgcgcgccat taccgagtcc gggctgcgcg ttggtgcgga tatctcggta gtgggatacg      180

acgataccga agatagctca tgttatatcc cgccgttaac caccatcaaa caggattttc      240

gcctgctggg gcaaaccagc gtggaccgct tgctgcaact ctctcagggc caggcggtga      300

agggcaatca gctgttgccc gtctcactgg tgaaaagaaa aaccaccctg gcgcccaata      360

cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt      420

cccgactgga aagcgggcag tgagcgcaat attctgaaat gagctgttga caattaatca      480

tccggctcgt ataatgtgtg gaattgtgag cggataacaa ttttcacaca ggaaacagaa      540

ttctagcatt gtgagcggat aacaattccc ctctagaaat aattttgttt aactttaaga      600

aggagatata ccatgaaacg tccggcagca accaaaaaag caggtcaggc caagaaaaaa      660

aaaggtggtg gttcaggcaa caactatatt ctgggtctgg atattggtat taccagcgtt      720

ggttatggta ttgttgatag cgatacccgt gaaattaaag atgccggtgt tcgtctgttt      780

ccggaagcaa atgttgataa taatgaaggt cgtcgtagca aacgtggtgc acgtcgtctg      840

aaacgtcgtc gtattcatcg tctggatcgt gttaaacatc tgctggcaga atatgatctg      900

ctggatctga ccaatattcc gaaaagcacc aatccgtatc agacccgtgt taaaggtctg      960

aatgaaaagc tgagcaaaga tgaactggtt attgcactgc tgcatattgc aaaacgccgt     1020

ggcattcata atgtgaatgt tatgatggat gataacgata gcggtaatga actgagcacc     1080

aaagatcagc tgaagaagaa tgcaaaagca ctgagcgata aatatgtttg tgaactgcag     1140

ctggaacgct ttgagcagga ttataaagtt cgtggtgaaa agaaccgctt caaaaccgaa     1200

gattttgttc gtgaagcacg taaactgctg gaaacccaga gcaaattttt cgaaattgat     1260

cagacgttca tcatgcgcta tatcgaactg attgaaaccc gtcgcgaata ttttgaaggt     1320

ccgggtaaag gtagcccgtt tggttgggaa ggtaatatca agaaatggtt tgagcagatg     1380

atgggccact gtacctattt tccagaagaa ctgcgtagcg tcaaatatag c              1431


<210>  123
<211>  156
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  SluCas9 tracr RNA

<400>  123
cttgtactta tacctaaaat tacagaatct actgaaacaa gacaatatgt cgtgtttatc       60

ccatcaattt attggtggga tttttttatg tttttagcaa aaagtaatac catactttat      120

atttttaaat tataataaag atataaataa aggtgg                                156


<210>  124
<211>  3315
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  SluCas9 codon optimized DNA

<400>  124
atgaaacgtc cggcagcaac caaaaaagca ggtcaggcca agaaaaaaaa aggtggtggt       60

tcaggtaacc agaaatttat cctgggtctg gatattggta ttaccagcgt tggttatggc      120

ctgattgatt acgaaaccaa aaacattatt gatgccggtg ttcgtctgtt tccggaagca      180

aatgttgaaa ataatgaagg tcgtcgtagc aaacgtggta gccgtcgtct gaaacgtcgt      240

cgtattcatc gtctggaacg tgttaaaaaa ctgctggaag attataacct gctggatcag      300

agccagattc cgcagagcac caatccgtat gcaattcgtg ttaaaggtct gagcgaagca      360

ctgagcaaag atgaactggt tattgcactg ctgcatattg caaaacgccg tggcattcat      420

aaaatcgatg tgattgatag caatgacgat gtgggtaatg aactgagcac caaagaacag      480

ctgaacaaaa atagcaaact gctgaaagac aaattcgtgt gtcagattca gctggaacgt      540

atgaatgaag gccaggttcg tggtgaaaag aatcgcttta aaaccgcaga catcatcaaa      600

gaaattatcc agctgctgaa cgtgcagaaa aacttccatc agctggatga aaacttcatc      660

aacaaataca tcgagctggt tgaaatgcgt cgcgaatatt ttgaaggtcc gggtaaaggt      720

agcccgtatg gttgggaagg tgatccgaaa gcatggtatg aaaccctgat gggtcattgt      780

acctattttc cggatgaact gcgtagcgtt aaatatgcct atagcgcaga cctgtttaat      840

gcactgaatg atctgaataa cctggtgatt cagcgtgatg gtctgagcaa actggaatat      900

catgagaaat atcacatcat cgaaaacgtg ttcaaacaga agaagaaacc gaccctgaaa      960

caaatcgcca acgaaattaa tgtgaacccg gaagatatta aaggctaccg tattaccaaa     1020

agcggtaaac cgcagttcac cgaatttaaa ctgtatcacg atctgaaaag cgtgctgttt     1080

gatcagagca ttctggaaaa tgaagatgtg ctggaccaga ttgcagaaat tctgaccatt     1140

tatcaggaca aagacagcat caaaagcaaa ctgaccgaac tggatattct gctgaatgaa     1200

gaagataaag agaacattgc acagctgacc ggttataccg gcacccatcg tctgagcctg     1260

aaatgtattc gtctggtact ggaagaacag tggtatagca gccgtaatca gatggaaatc     1320

tttacccatc tgaacattaa accgaagaaa atcaatctga ccgcagccaa caaaattccg     1380

aaagccatga ttgatgagtt tattctgagt ccggttgtga aacgtacctt tggtcaggca     1440

attaacctga tcaacaaaat cattgaaaaa tatggcgtgc ctgaggatat cattattgaa     1500

ctggcacgtg aaaacaacag caaagataaa cagaaattca tcaacgagat gcagaagaag     1560

aacgaaaata cccgcaaacg gattaacgag atcattggca aatatggtaa tcagaatgcc     1620

aaacgcctgg tggaaaaaat tcgtctgcat gatgaacaag agggcaaatg tctgtatagc     1680

ctggaaagca ttcctctgga agatctgctg aacaatccga atcattatga agtggatcac     1740

attattccgc gtagcgtgag ctttgataat tcctatcata ataaagtgct ggtgaaacag     1800

agcgaaaact ccaaaaaatc caacctgaca ccgtatcagt atttcaatag cggcaaatcc     1860

aaactgagct acaaccagtt taaacagcat attctgaacc tgagcaaaag ccaggatcgc     1920

atcagcaaga agaagaagga gtacctgctg gaagaacgcg acatcaacaa atttgaagtg     1980

cagaaagaat ttatcaaccg caacctggtt gatacccgtt atgcaacccg tgaactgacc     2040

aattatctga aagcatattt cagcgccaac aacatgaacg tgaaagtgaa aacgattaac     2100

ggcagcttta ccgattatct gcgtaaagtg tggaaattca aaaaagaacg caaccacggc     2160

tataaacatc atgccgaaga tgccctgatt attgcaaatg cagatttcct gtttaaagaa     2220

aacaaaaaac tgaaagccgt caacagcgtg ctggaaaaac cggaaattga gacaaaacag     2280

ctggacattc aggttgatag cgaagataat tacagcgaaa tgtttatcat cccgaaacag     2340

gtgcaggata tcaaagattt tcgcaacttc aaatatagcc accgcgttga caaaaaacct     2400

aatcgtcagc tgattaacga taccctgtat agcacccgca aaaaagataa cagcacctat     2460

attgtgcaga ccattaaaga catctacgcc aaagataata ccaccctgaa aaaacagttc     2520

gacaaaagcc cagaaaaatt tctgatgtat cagcatgatc cgcgtacctt cgaaaaactg     2580

gaagttatta tgaaacagta tgccaacgag aaaaatccgc tggccaaata tcacgaagaa     2640

accggtgaat atctgaccaa atattccaag aagaacaacg gtccgatcgt taaatccctg     2700

aaatatatcg gtaataaact gggcagccat ctggatgtta cccatcagtt taaaagctcc     2760

acaaagaagc tggttaaact gtccatcaaa ccgtatcgct ttgatgtgta tctgaccgac     2820

aaaggctata aattcattac catcagctat ctggacgtgc tgaaaaaaga caactattat     2880

tatatcccgg aacagaaata tgataaactg aaactgggta aagccatcga taaaaacgcc     2940

aaatttatcg ccagcttcta caaaaacgac ctgattaaac tggatggcga gatctataaa     3000

atcatcggtg ttaatagcga cacccgcaat atgattgagc tggatctgcc ggatattcgc     3060

tataaagaat attgcgaact gaacaacatt aaaggcgaac cgcgtatcaa aaagaccatc     3120

ggcaaaaaag tgaatagcat cgagaaactg accaccgatg ttctgggtaa tgtgtttacc     3180

aatacccagt ataccaaacc tcagctgctg ttcaaacgcg gtaatggcgg aggatctggc     3240

ccccctaaga aaaagcggaa ggtgggtgga agcggaggca gcgggggatc aggccatcat     3300

catcaccatc attaa                                                      3315


<210>  125
<211>  1056
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  SluCas9  polypeptide

<400>  125

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser 
65                  70                  75                  80  


Gln Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp 
        115                 120                 125             


Asp Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met 
145                 150                 155                 160 


Asn Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp 
                165                 170                 175     


Ile Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His 
            180                 185                 190         


Gln Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp 
    210                 215                 220                 


Glu Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp 
            260                 265                 270         


Gly Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu 
    290                 295                 300                 


Ile Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser 
305                 310                 315                 320 


Gly Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser 
                325                 330                 335     


Val Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln 
            340                 345                 350         


Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser 
        355                 360                 365             


Lys Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn 
    370                 375                 380                 


Ile Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln 
                405                 410                 415     


Met Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu 
            420                 425                 430         


Thr Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn 
    450                 455                 460                 


Lys Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met 
                485                 490                 495     


Gln Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly 
            500                 505                 510         


Lys Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu 
        515                 520                 525             


His Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro 
    530                 535                 540                 


Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu 
                565                 570                 575     


Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys 
    610                 615                 620                 


Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys 
        675                 680                 685             


Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu 
                725                 730                 735     


Thr Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu 
            740                 745                 750         


Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn 
        755                 760                 765             


Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile 
785                 790                 795                 800 


Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys 
                805                 810                 815     


Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp 
            820                 825                 830         


Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn 
        835                 840                 845             


Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys 
865                 870                 875                 880 


Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe 
                885                 890                 895     


Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser 
        915                 920                 925             


Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln 
    930                 935                 940                 


Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu 
                965                 970                 975     


Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu 
            980                 985                 990         


Leu Asp Leu Pro Asp Ile Arg Tyr  Lys Glu Tyr Cys Glu  Leu Asn Asn 
        995                 1000                 1005             


Ile Lys  Gly Glu Pro Arg Ile  Lys Lys Thr Ile Gly  Lys Lys Val 
    1010                 1015                 1020             


Asn Ser  Ile Glu Lys Leu Thr  Thr Asp Val Leu Gly  Asn Val Phe 
    1025                 1030                 1035             


Thr Asn  Thr Gln Tyr Thr Lys  Pro Gln Leu Leu Phe  Lys Arg Gly 
    1040                 1045                 1050             


Asn Gly  Gly 
    1055     


<210>  126
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Residues 47-57 of HIV-1 TAT

<400>  126

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  127
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Penetratin

<400>  127

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  128
<211>  150
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA-Ex6

<400>  128
ggugaacgug gaugaaguug guuuuaguac ucuggaaaca gaaucuacug aaacaagaca       60

auaugucgug uuuaucccau caauuuauug gugggauuuu uuucuagcau aaccccuugg      120

ggccucuaaa cgggucuuga gggguuuuuu                                       150


<210>  129
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-1-A

<400>  129
ggtgaacgtg gatgaagttg tggggtac                                          28


<210>  130
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-1-B

<400>  130
gcggtacccc acaacttcat ccacgttcac cgg                                    33


<210>  131
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-2-A

<400>  131
agtgaacgtg gatgaagttg tggggtac                                          28


<210>  132
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-2-B

<400>  132
gcggtacccc acaacttcat ccacgttcac tgg                                    33


<210>  133
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-3-A

<400>  133
cgtgaacgtg gatgaagttg tggggtac                                          28


<210>  134
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-3-B

<400>  134
gcggtacccc acaacttcat ccacgttcac ggg                                    33


<210>  135
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-4-A

<400>  135
tgtgaacgtg gatgaagttg tggggtac                                          28


<210>  136
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-4-B

<400>  136
gcggtacccc acaacttcat ccacgttcac agg                                    33


<210>  137
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-5-A

<400>  137
gatgaacgtg gatgaagttg tggggtac                                          28


<210>  138
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-5-B

<400>  138
gcggtacccc acaacttcat ccacgttcat cgg                                    33


<210>  139
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-6-A

<400>  139
gctgaacgtg gatgaagttg tggggtac                                          28


<210>  140
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-6-B

<400>  140
gcggtacccc acaacttcat ccacgttcag cgg                                    33


<210>  141
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-7-A

<400>  141
gttgaacgtg gatgaagttg tggggtac                                          28


<210>  142
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-7-B

<400>  142
gcggtacccc acaacttcat ccacgttcaa cgg                                    33


<210>  143
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-8-A

<400>  143
ggagaacgtg gatgaagttg tggggtac                                          28


<210>  144
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-8-B

<400>  144
gcggtacccc acaacttcat ccacgttctc cgg                                    33


<210>  145
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-9-A

<400>  145
ggcgaacgtg gatgaagttg tggggtac                                          28


<210>  146
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-9-B

<400>  146
gcggtacccc acaacttcat ccacgttcgc cgg                                    33


<210>  147
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-10-A

<400>  147
ggggaacgtg gatgaagttg tggggtac                                          28


<210>  148
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-10-B

<400>  148
gcggtacccc acaacttcat ccacgttccc cgg                                    33


<210>  149
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-11-A

<400>  149
ggtaaacgtg gatgaagttg tggggtac                                          28


<210>  150
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-11-B

<400>  150
gcggtacccc acaacttcat ccacgtttac cgg                                    33


<210>  151
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-12-A

<400>  151
ggtcaacgtg gatgaagttg tggggtac                                          28


<210>  152
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-12-B

<400>  152
gcggtacccc acaacttcat ccacgttgac cgg                                    33


<210>  153
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-13-A

<400>  153
ggttaacgtg gatgaagttg tggggtac                                          28


<210>  154
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-13-B

<400>  154
gcggtacccc acaacttcat ccacgttaac cgg                                    33


<210>  155
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-14-A

<400>  155
ggtgcacgtg gatgaagttg tggggtac                                          28


<210>  156
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-14-B

<400>  156
gcggtacccc acaacttcat ccacgtgcac cgg                                    33


<210>  157
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-15-A

<400>  157
ggtgtacgtg gatgaagttg tggggtac                                          28


<210>  158
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-15-B

<400>  158
gcggtacccc acaacttcat ccacgtacac cgg                                    33


<210>  159
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-16-A

<400>  159
ggtggacgtg gatgaagttg tggggtac                                          28


<210>  160
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-16-B

<400>  160
gcggtacccc acaacttcat ccacgtccac cgg                                    33


<210>  161
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-17-A

<400>  161
ggtgaccgtg gatgaagttg tggggtac                                          28


<210>  162
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-17-B

<400>  162
gcggtacccc acaacttcat ccacggtcac cgg                                    33


<210>  163
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-18-A

<400>  163
ggtgatcgtg gatgaagttg tggggtac                                          28


<210>  164
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-18-B

<400>  164
gcggtacccc acaacttcat ccacgatcac cgg                                    33


<210>  165
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-19-A

<400>  165
ggtgagcgtg gatgaagttg tggggtac                                          28


<210>  166
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-19-B

<400>  166
gcggtacccc acaacttcat ccacgctcac cgg                                    33


<210>  167
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-20-A

<400>  167
ggtgaaagtg gatgaagttg tggggtac                                          28


<210>  168
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-20-B

<400>  168
gcggtacccc acaacttcat ccactttcac cgg                                    33


<210>  169
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-21-A

<400>  169
ggtgaatgtg gatgaagttg tggggtac                                          28


<210>  170
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-21-B

<400>  170
gcggtacccc acaacttcat ccacattcac cgg                                    33


<210>  171
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-22-A

<400>  171
ggtgaaggtg gatgaagttg tggggtac                                          28


<210>  172
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-22-B

<400>  172
gcggtacccc acaacttcat ccaccttcac cgg                                    33


<210>  173
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-23-A

<400>  173
ggtgaacatg gatgaagttg tggggtac                                          28


<210>  174
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-23-B

<400>  174
gcggtacccc acaacttcat ccatgttcac cgg                                    33


<210>  175
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-24-A

<400>  175
ggtgaacctg gatgaagttg tggggtac                                          28


<210>  176
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-24-B

<400>  176
gcggtacccc acaacttcat ccaggttcac cgg                                    33


<210>  177
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-25-A

<400>  177
ggtgaacttg gatgaagttg tggggtac                                          28


<210>  178
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-25-B

<400>  178
gcggtacccc acaacttcat ccaagttcac cgg                                    33


<210>  179
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-26-A

<400>  179
ggtgaacgag gatgaagttg tggggtac                                          28


<210>  180
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-26-B

<400>  180
gcggtacccc acaacttcat cctcgttcac cgg                                    33


<210>  181
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-27-A

<400>  181
ggtgaacgcg gatgaagttg tggggtac                                          28


<210>  182
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-27-B

<400>  182
gcggtacccc acaacttcat ccgcgttcac cgg                                    33


<210>  183
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-28-A

<400>  183
ggtgaacggg gatgaagttg tggggtac                                          28


<210>  184
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-28-B

<400>  184
gcggtacccc acaacttcat ccccgttcac cgg                                    33


<210>  185
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-29-A

<400>  185
ggtgaacgta gatgaagttg tggggtac                                          28


<210>  186
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-29-B

<400>  186
gcggtacccc acaacttcat ctacgttcac cgg                                    33


<210>  187
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-30-A

<400>  187
ggtgaacgtc gatgaagttg tggggtac                                          28


<210>  188
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-30-B

<400>  188
gcggtacccc acaacttcat cgacgttcac cgg                                    33


<210>  189
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-31-A

<400>  189
ggtgaacgtt gatgaagttg tggggtac                                          28


<210>  190
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-31-B

<400>  190
gcggtacccc acaacttcat caacgttcac cgg                                    33


<210>  191
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-32-A

<400>  191
ggtgaacgtg aatgaagttg tggggtac                                          28


<210>  192
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-32-B

<400>  192
gcggtacccc acaacttcat tcacgttcac cgg                                    33


<210>  193
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-33-A

<400>  193
ggtgaacgtg catgaagttg tggggtac                                          28


<210>  194
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-33-B

<400>  194
gcggtacccc acaacttcat gcacgttcac cgg                                    33


<210>  195
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-34-A

<400>  195
ggtgaacgtg tatgaagttg tggggtac                                          28


<210>  196
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-34-B

<400>  196
gcggtacccc acaacttcat acacgttcac cgg                                    33


<210>  197
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-35-A

<400>  197
ggtgaacgtg gctgaagttg tggggtac                                          28


<210>  198
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-35-B

<400>  198
gcggtacccc acaacttcag ccacgttcac cgg                                    33


<210>  199
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-36-A

<400>  199
ggtgaacgtg gttgaagttg tggggtac                                          28


<210>  200
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-36-B

<400>  200
gcggtacccc acaacttcaa ccacgttcac cgg                                    33


<210>  201
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-37-A

<400>  201
ggtgaacgtg ggtgaagttg tggggtac                                          28


<210>  202
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-37-B

<400>  202
gcggtacccc acaacttcac ccacgttcac cgg                                    33


<210>  203
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-38-A

<400>  203
ggtgaacgtg gaagaagttg tggggtac                                          28


<210>  204
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-38-B

<400>  204
gcggtacccc acaacttctt ccacgttcac cgg                                    33


<210>  205
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-39-A

<400>  205
ggtgaacgtg gacgaagttg tggggtac                                          28


<210>  206
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-39-B

<400>  206
gcggtacccc acaacttcgt ccacgttcac cgg                                    33


<210>  207
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-40-A

<400>  207
ggtgaacgtg gaggaagttg tggggtac                                          28


<210>  208
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-40-B

<400>  208
gcggtacccc acaacttcct ccacgttcac cgg                                    33


<210>  209
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-41-A

<400>  209
ggtgaacgtg gataaagttg tggggtac                                          28


<210>  210
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-41-B

<400>  210
gcggtacccc acaactttat ccacgttcac cgg                                    33


<210>  211
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-42-A

<400>  211
ggtgaacgtg gatcaagttg tggggtac                                          28


<210>  212
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-42-B

<400>  212
gcggtacccc acaacttgat ccacgttcac cgg                                    33


<210>  213
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-43-A

<400>  213
ggtgaacgtg gattaagttg tggggtac                                          28


<210>  214
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-43-B

<400>  214
gcggtacccc acaacttaat ccacgttcac cgg                                    33


<210>  215
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-44-A

<400>  215
ggtgaacgtg gatgcagttg tggggtac                                          28


<210>  216
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-44-B

<400>  216
gcggtacccc acaactgcat ccacgttcac cgg                                    33


<210>  217
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-45-A

<400>  217
ggtgaacgtg gatgtagttg tggggtac                                          28


<210>  218
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-45-B

<400>  218
gcggtacccc acaactacat ccacgttcac cgg                                    33


<210>  219
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-46-A

<400>  219
ggtgaacgtg gatggagttg tggggtac                                          28


<210>  220
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-46-B

<400>  220
gcggtacccc acaactccat ccacgttcac cgg                                    33


<210>  221
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-47-A

<400>  221
ggtgaacgtg gatgacgttg tggggtac                                          28


<210>  222
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-47-B

<400>  222
gcggtacccc acaacgtcat ccacgttcac cgg                                    33


<210>  223
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-48-A

<400>  223
ggtgaacgtg gatgatgttg tggggtac                                          28


<210>  224
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-48-B

<400>  224
gcggtacccc acaacatcat ccacgttcac cgg                                    33


<210>  225
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-49-A

<400>  225
ggtgaacgtg gatgaggttg tggggtac                                          28


<210>  226
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-49-B

<400>  226
gcggtacccc acaacctcat ccacgttcac cgg                                    33


<210>  227
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-50-A

<400>  227
ggtgaacgtg gatgaaattg tggggta                                           27


<210>  228
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-50-B

<400>  228
gcggtacccc acaatttcat ccacgttcac cgg                                    33


<210>  229
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-51-A

<400>  229
ggtgaacgtg gatgaacttg tggggtac                                          28


<210>  230
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-51-B

<400>  230
gcggtacccc acaagttcat ccacgttcac cgg                                    33


<210>  231
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-52-A

<400>  231
ggtgaacgtg gatgaatttg tggggtac                                          28


<210>  232
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-52-B

<400>  232
gcggtacccc acaaattcat ccacgttcac cgg                                    33


<210>  233
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-53-A

<400>  233
ggtgaacgtg gatgaagatg tggggtac                                          28


<210>  234
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-53-B

<400>  234
gcggtacccc acatcttcat ccacgttcac cgg                                    33


<210>  235
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-54-A

<400>  235
ggtgaacgtg gatgaagctg tggggtac                                          28


<210>  236
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-54-B

<400>  236
gcggtacccc acagcttcat ccacgttcac cgg                                    33


<210>  237
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-55-A

<400>  237
ggtgaacgtg gatgaaggtg tggggtac                                          28


<210>  238
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-55-B

<400>  238
gcggtacccc acaccttcat ccacgttcac cgg                                    33


<210>  239
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-56-A

<400>  239
ggtgaacgtg gatgaagtag tggggtac                                          28


<210>  240
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-56-B

<400>  240
gcggtacccc actacttcat ccacgttcac cgg                                    33


<210>  241
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-57-A

<400>  241
ggtgaacgtg gatgaagtcg tggggtac                                          28


<210>  242
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-57-B

<400>  242
gcggtacccc acgacttcat ccacgttcac cgg                                    33


<210>  243
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-58-A

<400>  243
ggtgaacgtg gatgaagtgg tggggtac                                          28


<210>  244
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-58-B

<400>  244
gcggtacccc accacttcat ccacgttcac cgg                                    33


<210>  245
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-59-A

<400>  245
ggtgaacgtg gatgaagtta tggggtac                                          28


<210>  246
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-59-B

<400>  246
gcggtacccc ataacttcat ccacgttcac cgg                                    33


<210>  247
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-60-A

<400>  247
ggtgaacgtg gatgaagttc tggggtac                                          28


<210>  248
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-60-B

<400>  248
gcggtacccc agaacttcat ccacgttcac cgg                                    33


<210>  249
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-61-A

<400>  249
ggtgaacgtg gatgaagttt tggggtac                                          28


<210>  250
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  R01-61-B

<400>  250
gcggtacccc aaaacttcat ccacgttcac cgg                                    33


<210>  251
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 1 target sequence

<400>  251
ggagtccgag cagaagaaga a                                                 21


<210>  252
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 2 target sequence

<400>  252
ggacatcgat gtcctcccca t                                                 21


<210>  253
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 3 target sequence

<400>  253
ggtcacctcc aatgactagg g                                                 21


<210>  254
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 4 target sequence

<400>  254
ggctccccat tggcctgctt cg                                                22


<210>  255
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 5 target sequence

<400>  255
ggtgcgccac cggttgatgt ga                                                22


<210>  256
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 6 target sequence

<400>  256
ggcgccaccg gttgatgtga t                                                 21


<210>  257
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 7 target sequence

<400>  257
ggccgtttgt actttgtcct c                                                 21


<210>  258
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 8 target sequence

<400>  258
ggcacagatg agaaactcag g                                                 21


<210>  259
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 9 target sequence

<400>  259
ggattgggtg ttcagggcag ag                                                22


<210>  260
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 10 target sequence

<400>  260
ggtggcgaga ggggccgaga t                                                 21


<210>  261
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 11 target sequence

<400>  261
ggggccgaga ttgggtgttc                                                   20


<210>  262
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 12 target sequence

<400>  262
ggtgccatta gctaaatgca t                                                 21


<210>  263
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 13 target sequence

<400>  263
ggtaccaccc acaggtgcca g                                                 21


<210>  264
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 14 target sequence

<400>  264
ggaaagcctc tgggccagga a                                                 21


<210>  265
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 15 target sequence

<400>  265
ggacacccac ggagagcgct gt                                                22


<210>  266
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 16 target sequence

<400>  266
ggtccagttg gtgacaaata c                                                 21


<210>  267
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 17 target sequence

<400>  267
ggttttaaca cttccctagc ca                                                22


<210>  268
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 18 target sequence

<400>  268
ggcttaatta gctcctttgg ct                                                22


<210>  269
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 19 target sequence

<400>  269
ggcttaatta gctcctttgg c                                                 21


<210>  270
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 20 target sequence

<400>  270
ggtgcatatg atgatagtat ta                                                22


<210>  271
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 21 target sequence

<400>  271
ggaatgtatg ctggctttta ag                                                22


<210>  272
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 22 target sequence

<400>  272
ggaaatgtat gctggctttt aa                                                22


<210>  273
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 23 target sequence

<400>  273
ggaaaatgta tgctggcttt ta                                                22


<210>  274
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 24 target sequence

<400>  274
ggtaaaatgt atgctggctt tt                                                22


<210>  275
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 25 target sequence

<400>  275
ggcttaaaga tgatctctta cc                                                22


<210>  276
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 26 target sequence

<400>  276
ggttaaagat gatctcttac ct                                                22


<210>  277
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 27 target sequence

<400>  277
ggtaataaaa ttcaaacatc ct                                                22


<210>  278
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 28 target sequence

<400>  278
ggtaaagcat agtgcaatgg at                                                22


<210>  279
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 29 target sequence

<400>  279
ggttaaataa agcatagtgc aa                                                22


<210>  280
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 30 target sequence

<400>  280
ggatttatga gatcaacagc ac                                                22


<210>  281
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 31 target sequence

<400>  281
ggcccatgct ctgaccgctc ga                                                22


<210>  282
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 32 target sequence

<400>  282
ggccatcgag cggtcagagc at                                                22


<210>  283
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 33 target sequence

<400>  283
gggcaaaagc tcatgtgata                                                   20


<210>  284
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 34 target sequence

<400>  284
ggactgaggc ttatgttcca tg                                                22


<210>  285
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 35 target sequence

<400>  285
ggagagtgta caaactcaca a                                                 21


<210>  286
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 36 target sequence

<400>  286
ggactagcat tataatgcac ca                                                22


<210>  287
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 37 target sequence

<400>  287
ggtcagaaga gattagttag ta                                                22


<210>  288
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 38 target sequence

<400>  288
ggtgagagtg ccatctcttc ct                                                22


<210>  289
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 39 target sequence

<400>  289
ggtggaccac atggctttgc tc                                                22


<210>  290
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 40 target sequence

<400>  290
ggtgagcaaa gccatgtggt cc                                                22


<210>  291
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 41 target sequence

<400>  291
ggattaatga catacgcatt t                                                 21


<210>  292
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 42 target sequence

<400>  292
ggagattaat gacatacgca tt                                                22


<210>  293
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 43 target sequence

<400>  293
ggttcaatcc tcttgtcacc tg                                                22


<210>  294
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 44 target sequence

<400>  294
ggacatctct atgtcggcca c                                                 21


<210>  295
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 45 target sequence

<400>  295
ggaaaaccta ccgcaagttg cc                                                22


<210>  296
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 46 target sequence

<400>  296
ggtggactac atagttgtgt ga                                                22


<210>  297
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 47 target sequence

<400>  297
ggctgccaga ctctctgaac cc                                                22


<210>  298
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 48 target sequence

<400>  298
ggatccctcg tataacaata                                                   20


<210>  299
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 49 target sequence

<400>  299
ggtatcgcat agtgcaaaga at                                                22


<210>  300
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 50 target sequence

<400>  300
ggctcggtcc tctcgtcacc tg                                                22


<210>  301
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 51 target sequence

<400>  301
ggacgctccc ggagagcgct gg                                                22


<210>  302
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 52 target sequence

<400>  302
ggccatggcg cggtcagagg gt                                                22


<210>  303
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 53 target sequence

<400>  303
ggctcggctc caatgacgag gg                                                22


<210>  304
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 54 target sequence

<400>  304
ggcacttcga tgacctcccc gt                                                22


<210>  305
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 55 target sequence

<400>  305
ggagtgggtg ttcaggaccg cg                                                22


<210>  306
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 56 target sequence

<400>  306
ggctgctacc cacaggtgca ag                                                22


<210>  307
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 57 target sequence

<400>  307
ggaagatgta tcctggaatt ta                                                22


<210>  308
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 58 target sequence

<400>  308
ggttttatca ctacccaaga ca                                                22


<210>  309
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 59 target sequence

<400>  309
ggcggccagg ctccctgaaa cc                                                22


<210>  310
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 60 target sequence

<400>  310
ggactggtat tataatacaa ca                                                22


<210>  311
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 61 target sequence

<400>  311
ggtgagagtg acatttcgta ct                                                22


<210>  312
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 62 target sequence

<400>  312
ggtgcgcccc cgggtgaggt gc                                                22


<210>  313
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 63 target sequence

<400>  313
ggcagtttga gcagaaaaag aa                                                22


<210>  314
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 64 target sequence

<400>  314
ggtctgtaga gataagtgag ta                                                22


<210>  315
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 65 target sequence

<400>  315
ggaagtgtgt acaaactcaa ga                                                22


<210>  316
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 66 target sequence

<400>  316
ggtatcatgg atgctgactt tt                                                22


<210>  317
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 67 target sequence

<400>  317
ggctttacta gcccctgtgg c                                                 21


<210>  318
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 68 target sequence

<400>  318
ggcacggagg agaaaagcag g                                                 21


<210>  319
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 69 target sequence

<400>  319
ggatttgtga gatctaaaga ac                                                22


<210>  320
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 70 target sequence

<400>  320
ggcgttgatg acattcgcat tt                                                22


<210>  321
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 71 target sequence

<400>  321
ggcttataga tcatctaata cc                                                22


<210>  322
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 72 target sequence

<400>  322
ggtggcctcc atagttgggt gg                                                22


<210>  323
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 73 target sequence

<400>  323
ggtactagag ttcaaacata ct                                                22


<210>  324
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 74 target sequence

<400>  324
ggcccctgct ctgagcactc gg                                                22


<210>  325
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 75 target sequence

<400>  325
ggaggaccac atggcctgcc tc                                                22


<210>  326
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 76 target sequence

<400>  326
ggaacagctg ccgcaaattg cc                                                22


<210>  327
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 77 target sequence

<400>  327
ggctccgtat tggctggctt cg                                                22


<210>  328
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 78 target sequence

<400>  328
ggccagccga tgacaaatac                                                   20


<210>  329
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 79 target sequence

<400>  329
ggacgtctct acgtcggcgg c                                                 21


<210>  330
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 80 target sequence

<400>  330
ggccggcgcg aggggccgag ag                                                22


<210>  331
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 81 target sequence

<400>  331
ggactgtttg tactttttca tc                                                22


<210>  332
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 82 target sequence

<400>  332
ggtgcttatg atgatgacat ta                                                22


<210>  333
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 83 target sequence

<400>  333
ggccgcgtcc gattgatgtg at                                                22


<210>  334
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 84 target sequence

<400>  334
ggctttatga gcaccttagg ct                                                22


<210>  335
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 85 target sequence

<400>  335
ggatccctcc tatgaccatg                                                   20


<210>  336
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 86 target sequence

<400>  336
ggataaaggt gacctcttac gt                                                22


<210>  337
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 87 target sequence

<400>  337
ggactgtggc ttagggtcca gg                                                22


<210>  338
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 88 target sequence

<400>  338
ggtgaggaaa cccaggcggt cc                                                22


<210>  339
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 89 target sequence

<400>  339
ggaaatgtat acaggcaatt aa                                                22


<210>  340
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 90 target sequence

<400>  340
ggttgaatca agcatagtcc ga                                                22


<210>  341
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 91 target sequence

<400>  341
gggctacggc tcatgagata                                                   20


<210>  342
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 92 target sequence

<400>  342
ggcgggccgc gattggcagt tc                                                22


<210>  343
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 93 target sequence

<400>  343
ggctgcgatt atctaaatcc at                                                22


<210>  344
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 94 target sequence

<400>  344
ggagcttgat tacatacgca tg                                                22


<210>  345
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 95 target sequence

<400>  345
ggaatgtttg ctggcctcta gg                                                22


<210>  346
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  sgRNA 96 target sequence

<400>  346
ggaaagcctc tgcgccgggg g                                                 21


<210>  347
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-1-A

<400>  347
cctgagtccg agcagaagaa gaatggggta c                                      31


<210>  348
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-1-B

<400>  348
gcggtacccc attcttcttc tgctcggact cagggg                                 36


<210>  349
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-2-A

<400>  349
ggtgacatcg atgtcctccc cattggggta c                                      31


<210>  350
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-2-B

<400>  350
gcggtacccc aatggggagg acatcgatgt caccgg                                 36


<210>  351
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-3-A

<400>  351
gatgtcacct ccaatgacta gggtggggta c                                      31


<210>  352
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-3-B

<400>  352
gcggtacccc accctagtca ttggaggtga catcgg                                 36


<210>  353
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-4-A

<400>  353
gtcctcccca ttggcctgct tcgtggggta c                                      31


<210>  354
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-4-B

<400>  354
gcggtacccc acgaagcagg ccaatgggga ggacgg                                 36


<210>  355
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-5-A

<400>  355
caatgcgcca ccggttgatg tgatggggta c                                      31


<210>  356
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-5-B

<400>  356
gcggtacccc atcacatcaa ccggtggcgc attggg                                 36


<210>  357
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-6-A

<400>  357
aatgcgccac cggttgatgt gattggggta c                                      31


<210>  358
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-6-B

<400>  358
gcggtacccc aatcacatca accggtggcg cattgg                                 36


<210>  359
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-7-A

<400>  359
tctgccgttt gtactttgtc ctctggggta c                                      31


<210>  360
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-7-B

<400>  360
gcggtacccc agaggacaaa gtacaaacgg cagagg                                 36


<210>  361
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-8-A

<400>  361
ggggcacaga tgagaaactc aggtggggta c                                      31


<210>  362
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-8-B

<400>  362
gcggtacccc acctgagttt ctcatctgtg ccccgg                                 36


<210>  363
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-9-A

<400>  363
gagattgggt gttcagggca gagtggggta c                                      31


<210>  364
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-9-B

<400>  364
gcggtacccc actctgccct gaacacccaa tctcgg                                 36


<210>  365
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-10-A

<400>  365
agggtggcga gaggggccga gattggggta c                                      31


<210>  366
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-10-B

<400>  366
gcggtacccc aatctcggcc cctctcgcca ccctgg                                 36


<210>  367
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-11-A

<400>  367
agaggggccg agattgggtg ttctggggta c                                      31


<210>  368
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-11-B

<400>  368
gcggtacccc agaacaccca atctcggccc ctctgg                                 36


<210>  369
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-12-A

<400>  369
tgagtgccat tagctaaatg cattggggta c                                      31


<210>  370
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-12-B

<400>  370
gcggtacccc aatgcattta gctaatggca ctcagg                                 36


<210>  371
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-13-A

<400>  371
agggtaccac ccacaggtgc cagtggggta c                                      31


<210>  372
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-13-B

<400>  372
gcggtacccc actggcacct gtgggtggta ccctgg                                 36


<210>  373
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-14-A

<400>  373
tgggaaagcc tctgggccag gaatggggta c                                      31


<210>  374
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-14-B

<400>  374
gcggtacccc attcctggcc cagaggcttt cccagg                                 36


<210>  375
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-27-A

<400>  375
aggacaccca cggagagcgc tgttggggta c                                      31


<210>  376
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-27-B

<400>  376
gcggtacccc aacagcgctc tccgtgggtg tcctgg                                 36


<210>  377
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-28-A

<400>  377
agggtccagt tggtgacaaa tactggggta c                                      31


<210>  378
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-28-B

<400>  378
gcggtacccc agtatttgtc accaactgga ccctgg                                 36


<210>  379
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-29-A

<400>  379
aggttttaac acttccctag ccatggggta c                                      31


<210>  380
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-29-B

<400>  380
gcggtacccc atggctaggg aagtgttaaa acctgg                                 36


<210>  381
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-30-A

<400>  381
aggcttaatt agctcctttg gcttggggta c                                      31


<210>  382
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-30-B

<400>  382
gcggtacccc aagccaaagg agctaattaa gcctgg                                 36


<210>  383
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-31-A

<400>  383
agggcttaat tagctccttt ggctggggta c                                      31


<210>  384
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-31-B

<400>  384
gcggtacccc agccaaagga gctaattaag ccctgg                                 36


<210>  385
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-32-A

<400>  385
aggtgcatat gatgatagta ttatggggta c                                      31


<210>  386
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-32-B

<400>  386
gcggtacccc ataatactat catcatatgc acctgg                                 36


<210>  387
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-33-A

<400>  387
aggaatgtat gctggctttt aagtggggta c                                      31


<210>  388
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-33-B

<400>  388
gcggtacccc acttaaaagc cagcatacat tcctgg                                 36


<210>  389
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-34-A

<400>  389
aggaaatgta tgctggcttt taatggggta c                                      31


<210>  390
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-34-B

<400>  390
gcggtacccc attaaaagcc agcatacatt tcctgg                                 36


<210>  391
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-35-A

<400>  391
aggaaaatgt atgctggctt ttatggggta c                                      31


<210>  392
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-35-B

<400>  392
gcggtacccc ataaaagcca gcatacattt tcctgg                                 36


<210>  393
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-36-A

<400>  393
aggtaaaatg tatgctggct ttttggggta c                                      31


<210>  394
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-36-B

<400>  394
gcggtacccc aaaaagccag catacatttt acctgg                                 36


<210>  395
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-37-A

<400>  395
aggcttaaag atgatctctt acctggggta c                                      31


<210>  396
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-37-B

<400>  396
gcggtacccc aggtaagaga tcatctttaa gcctgg                                 36


<210>  397
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-38-A

<400>  397
aggttaaaga tgatctctta ccttggggta c                                      31


<210>  398
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-38-B

<400>  398
gcggtacccc aaggtaagag atcatcttta acctgg                                 36


<210>  399
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-39-A

<400>  399
aggtaataaa attcaaacat ccttggggta c                                      31


<210>  400
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-39-B

<400>  400
gcggtacccc aaggatgttt gaattttatt acctgg                                 36


<210>  401
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-40-A

<400>  401
aggtaaagca tagtgcaatg gattggggta c                                      31


<210>  402
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-40-B

<400>  402
gcggtacccc aatccattgc actatgcttt acctgg                                 36


<210>  403
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-41-A

<400>  403
aggttaaata aagcatagtg caatggggta c                                      31


<210>  404
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-41-B

<400>  404
gcggtacccc attgcactat gctttattta acctgg                                 36


<210>  405
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-42-A

<400>  405
aggatttatg agatcaacag cactggggta c                                      31


<210>  406
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-42-B

<400>  406
gcggtacccc agtgctgttg atctcataaa tcctgg                                 36


<210>  407
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-43-A

<400>  407
aggcccatgc tctgaccgct cgatggggta c                                      31


<210>  408
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-43-B

<400>  408
gcggtacccc atcgagcggt cagagcatgg gcctgg                                 36


<210>  409
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-44-A

<400>  409
aggccatcga gcggtcagag cattggggta c                                      31


<210>  410
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-44-B

<400>  410
gcggtacccc aatgctctga ccgctcgatg gcctgg                                 36


<210>  411
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-45-A

<400>  411
agggggcaaa agctcatgtg atatggggta c                                      31


<210>  412
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-45-B

<400>  412
gcggtacccc atatcacatg agcttttgcc ccctgg                                 36


<210>  413
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-46-A

<400>  413
aggactgagg cttatgttcc atgtggggta c                                      31


<210>  414
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-46-B

<400>  414
gcggtacccc acatggaaca taagcctcag tcctgg                                 36


<210>  415
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-47-A

<400>  415
agggagagtg tacaaactca caatggggta c                                      31


<210>  416
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-47-B

<400>  416
gcggtacccc attgtgagtt tgtacactct ccctgg                                 36


<210>  417
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-48-A

<400>  417
aggactagca ttataatgca ccatggggta c                                      31


<210>  418
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-48-B

<400>  418
gcggtacccc atggtgcatt ataatgctag tcctgg                                 36


<210>  419
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-49-A

<400>  419
aggtcagaag agattagtta gtatggggta c                                      31


<210>  420
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-49-B

<400>  420
gcggtacccc atactaacta atctcttctg acctgg                                 36


<210>  421
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-50-A

<400>  421
aggtgagagt gccatctctt ccttggggta c                                      31


<210>  422
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-50-B

<400>  422
gcggtacccc aaggaagaga tggcactctc acctgg                                 36


<210>  423
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-51-A

<400>  423
aggtggacca catggctttg ctctggggta c                                      31


<210>  424
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-51-B

<400>  424
gcggtacccc agagcaaagc catgtggtcc acctgg                                 36


<210>  425
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-52-A

<400>  425
aggtgagcaa agccatgtgg tcctggggta c                                      31


<210>  426
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-52-B

<400>  426
gcggtacccc aggaccacat ggctttgctc acctgg                                 36


<210>  427
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-53-A

<400>  427
agggattaat gacatacgca ttttggggta c                                      31


<210>  428
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-53-B

<400>  428
gcggtacccc aaaatgcgta tgtcattaat ccctgg                                 36


<210>  429
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-54-A

<400>  429
aggagattaa tgacatacgc atttggggta c                                      31


<210>  430
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-54-B

<400>  430
gcggtacccc aaatgcgtat gtcattaatc tcctgg                                 36


<210>  431
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-55-A

<400>  431
aggttcaatc ctcttgtcac ctgtggggta c                                      31


<210>  432
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-55-B

<400>  432
gcggtacccc acaggtgaca agaggattga acctgg                                 36


<210>  433
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-56-A

<400>  433
agggacatct ctatgtcggc cactggggta c                                      31


<210>  434
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-56-B

<400>  434
gcggtacccc agtggccgac atagagatgt ccctgg                                 36


<210>  435
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-57-A

<400>  435
aggaaaacct accgcaagtt gcctggggta c                                      31


<210>  436
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-57-B

<400>  436
gcggtacccc aggcaacttg cggtaggttt tcctgg                                 36


<210>  437
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-58-A

<400>  437
aggtggacta catagttgtg tgatggggta c                                      31


<210>  438
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-58-B

<400>  438
gcggtacccc atcacacaac tatgtagtcc acctgg                                 36


<210>  439
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-59-A

<400>  439
aggctgccag actctctgaa ccctggggta c                                      31


<210>  440
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-59-B

<400>  440
gcggtacccc agggttcaga gagtctggca gcctgg                                 36


<210>  441
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-60-A

<400>  441
aggggatccc tcgtataaca atatggggta c                                      31


<210>  442
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-60-B

<400>  442
gcggtacccc atattgttat acgagggatc ccctgg                                 36


<210>  443
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-61-A

<400>  443
aggtatcgca tagtgcaaag aattggggta c                                      31


<210>  444
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-61-B

<400>  444
gcggtacccc aattctttgc actatgcgat acctgg                                 36


<210>  445
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-62-A

<400>  445
aggctcggtc ctctcgtcac ctgtggggta c                                      31


<210>  446
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-62-B

<400>  446
gcggtacccc acaggtgacg agaggaccga gcctgg                                 36


<210>  447
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-63-A

<400>  447
aggacgctcc cggagagcgc tggtggggta c                                      31


<210>  448
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-63-B

<400>  448
gcggtacccc accagcgctc tccgggagcg tcctgg                                 36


<210>  449
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-64-A

<400>  449
aggccatggc gcggtcagag ggttggggta c                                      31


<210>  450
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-64-B

<400>  450
gcggtacccc aaccctctga ccgcgccatg gcctgg                                 36


<210>  451
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-65-A

<400>  451
aggctcggct ccaatgacga gggtggggta c                                      31


<210>  452
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-65-B

<400>  452
gcggtacccc accctcgtca ttggagccga gcctgg                                 36


<210>  453
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-66-A

<400>  453
aggcacttcg atgacctccc cgttggggta c                                      31


<210>  454
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-66-B

<400>  454
gcggtacccc aacggggagg tcatcgaagt gcctgg                                 36


<210>  455
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-67-A

<400>  455
aggagtgggt gttcaggacc gcgtggggta c                                      31


<210>  456
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-67-B

<400>  456
gcggtacccc acgcggtcct gaacacccac tcctgg                                 36


<210>  457
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-68-A

<400>  457
aggctgctac ccacaggtgc aagtggggta c                                      31


<210>  458
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-68-B

<400>  458
gcggtacccc acttgcacct gtgggtagca gcctgg                                 36


<210>  459
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-69-A

<400>  459
aggaagatgt atcctggaat ttatggggta c                                      31


<210>  460
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-69-B

<400>  460
gcggtacccc ataaattcca ggatacatct tcctgg                                 36


<210>  461
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-70-A

<400>  461
aggttttatc actacccaag acatggggta c                                      31


<210>  462
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-70-B

<400>  462
gcggtacccc atgtcttggg tagtgataaa acctgg                                 36


<210>  463
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-71-A

<400>  463
aggcggccag gctccctgaa acctggggta c                                      31


<210>  464
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-71-B

<400>  464
gcggtacccc aggtttcagg gagcctggcc gcctgg                                 36


<210>  465
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-72-A

<400>  465
aggactggta ttataataca acatggggta c                                      31


<210>  466
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-72-B

<400>  466
gcggtacccc atgttgtatt ataataccag tcctgg                                 36


<210>  467
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-73-A

<400>  467
aggtgagagt gacatttcgt acttggggta c                                      31


<210>  468
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-73-B

<400>  468
gcggtacccc aagtacgaaa tgtcactctc acctgg                                 36


<210>  469
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-74-A

<400>  469
aggtgcgccc ccgggtgagg tgctggggta c                                      31


<210>  470
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-74-B

<400>  470
gcggtacccc agcacctcac ccgggggcgc acctgg                                 36


<210>  471
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-75-A

<400>  471
aggcagtttg agcagaaaaa gaatggggta c                                      31


<210>  472
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-75-B

<400>  472
gcggtacccc attctttttc tgctcaaact gcctgg                                 36


<210>  473
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-76-A

<400>  473
aggtctgtag agataagtga gtatggggta c                                      31


<210>  474
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-76-B

<400>  474
gcggtacccc atactcactt atctctacag acctgg                                 36


<210>  475
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-77-A

<400>  475
aggaagtgtg tacaaactca agatggggta c                                      31


<210>  476
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-77-B

<400>  476
gcggtacccc atcttgagtt tgtacacact tcctgg                                 36


<210>  477
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-78-A

<400>  477
aggtatcatg gatgctgact ttttggggta c                                      31


<210>  478
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-78-B

<400>  478
gcggtacccc aaaaagtcag catccatgat acctgg                                 36


<210>  479
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-79-A

<400>  479
agggctttac tagcccctgt ggctggggta c                                      31


<210>  480
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-79-B

<400>  480
gcggtacccc agccacaggg gctagtaaag ccctgg                                 36


<210>  481
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-80-A

<400>  481
agggcacgga ggagaaaagc aggtggggta c                                      31


<210>  482
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-80-B

<400>  482
gcggtacccc acctgctttt ctcctccgtg ccctgg                                 36


<210>  483
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-81-A

<400>  483
aggatttgtg agatctaaag aactggggta c                                      31


<210>  484
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-81-B

<400>  484
gcggtacccc agttctttag atctcacaaa tcctgg                                 36


<210>  485
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-82-A

<400>  485
aggcgttgat gacattcgca ttttggggta c                                      31


<210>  486
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-82-B

<400>  486
gcggtacccc aaaatgcgaa tgtcatcaac gcctgg                                 36


<210>  487
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-83-A

<400>  487
aggcttatag atcatctaat acctggggta c                                      31


<210>  488
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-83-B

<400>  488
gcggtacccc aggtattaga tgatctataa gcctgg                                 36


<210>  489
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-84-A

<400>  489
aggtggcctc catagttggg tggtggggta c                                      31


<210>  490
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-84-B

<400>  490
gcggtacccc accacccaac tatggaggcc acctgg                                 36


<210>  491
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-85-A

<400>  491
aggtactaga gttcaaacat acttggggta c                                      31


<210>  492
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-85-B

<400>  492
gcggtacccc aagtatgttt gaactctagt acctgg                                 36


<210>  493
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-86-A

<400>  493
aggcccctgc tctgagcact cggtggggta c                                      31


<210>  494
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-86-B

<400>  494
gcggtacccc accgagtgct cagagcaggg gcctgg                                 36


<210>  495
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-87-A

<400>  495
aggaggacca catggcctgc ctctggggta c                                      31


<210>  496
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-87-B

<400>  496
gcggtacccc agaggcaggc catgtggtcc tcctgg                                 36


<210>  497
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-88-A

<400>  497
aggaacagct gccgcaaatt gcctggggta c                                      31


<210>  498
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-88-B

<400>  498
gcggtacccc aggcaatttg cggcagctgt tcctgg                                 36


<210>  499
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-89-A

<400>  499
aggctccgta ttggctggct tcgtggggta c                                      31


<210>  500
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-89-B

<400>  500
gcggtacccc acgaagccag ccaatacgga gcctgg                                 36


<210>  501
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-90-A

<400>  501
aggggccagc cgatgacaaa tactggggta c                                      31


<210>  502
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-90-B

<400>  502
gcggtacccc agtatttgtc atcggctggc ccctgg                                 36


<210>  503
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-91-A

<400>  503
agggacgtct ctacgtcggc ggctggggta c                                      31


<210>  504
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-91-B

<400>  504
gcggtacccc agccgccgac gtagagacgt ccctgg                                 36


<210>  505
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-92-A

<400>  505
aggccggcgc gaggggccga gagtggggta c                                      31


<210>  506
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-92-B

<400>  506
gcggtacccc actctcggcc cctcgcgccg gcctgg                                 36


<210>  507
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-93-A

<400>  507
aggactgttt gtactttttc atctggggta c                                      31


<210>  508
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-93-B

<400>  508
gcggtacccc agatgaaaaa gtacaaacag tcctgg                                 36


<210>  509
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-94-A

<400>  509
aggtgcttat gatgatgaca ttatggggta c                                      31


<210>  510
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-94-B

<400>  510
gcggtacccc ataatgtcat catcataagc acctgg                                 36


<210>  511
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-95-A

<400>  511
aggccgcgtc cgattgatgt gattggggta c                                      31


<210>  512
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-95-B

<400>  512
gcggtacccc aatcacatca atcggacgcg gcctgg                                 36


<210>  513
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-96-A

<400>  513
aggctttatg agcaccttag gcttggggta c                                      31


<210>  514
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-96-B

<400>  514
gcggtacccc aagcctaagg tgctcataaa gcctgg                                 36


<210>  515
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-97-A

<400>  515
aggggatccc tcctatgacc atgtggggta c                                      31


<210>  516
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-97-B

<400>  516
gcggtacccc acatggtcat aggagggatc ccctgg                                 36


<210>  517
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-98-A

<400>  517
aggataaagg tgacctctta cgttggggta c                                      31


<210>  518
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-98-B

<400>  518
gcggtacccc aacgtaagag gtcaccttta tcctgg                                 36


<210>  519
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-99-A

<400>  519
aggactgtgg cttagggtcc aggtggggta c                                      31


<210>  520
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-99-B

<400>  520
gcggtacccc acctggaccc taagccacag tcctgg                                 36


<210>  521
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-100-A

<400>  521
aggtgaggaa acccaggcgg tcctggggta c                                      31


<210>  522
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-100-B

<400>  522
gcggtacccc aggaccgcct gggtttcctc acctgg                                 36


<210>  523
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-101-A

<400>  523
aggaaatgta tacaggcaat taatggggta c                                      31


<210>  524
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-101-B

<400>  524
gcggtacccc attaattgcc tgtatacatt tcctgg                                 36


<210>  525
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-102-A

<400>  525
aggttgaatc aagcatagtc cgatggggta c                                      31


<210>  526
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-102-B

<400>  526
gcggtacccc atcggactat gcttgattca acctgg                                 36


<210>  527
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-103-A

<400>  527
agggggctac ggctcatgag atatggggta c                                      31


<210>  528
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-103-B

<400>  528
gcggtacccc atatctcatg agccgtagcc ccctgg                                 36


<210>  529
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-104-A

<400>  529
aggcgggccg cgattggcag ttctggggta c                                      31


<210>  530
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-104-B

<400>  530
gcggtacccc agaactgcca atcgcggccc gcctgg                                 36


<210>  531
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-105-A

<400>  531
aggctgcgat tatctaaatc cattggggta c                                      31


<210>  532
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-105-B

<400>  532
gcggtacccc aatggattta gataatcgca gcctgg                                 36


<210>  533
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-106-A

<400>  533
aggagcttga ttacatacgc atgtggggta c                                      31


<210>  534
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-106-B

<400>  534
gcggtacccc acatgcgtat gtaatcaagc tcctgg                                 36


<210>  535
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-107-A

<400>  535
aggaatgttt gctggcctct aggtggggta c                                      31


<210>  536
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-107-B

<400>  536
gcggtacccc acctagaggc cagcaaacat tcctgg                                 36


<210>  537
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-108-A

<400>  537
agggaaagcc tctgcgccgg gggtggggta c                                      31


<210>  538
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Ext-A-P-108-B

<400>  538
gcggtacccc acccccggcg cagaggcttt ccctgg                                 36


