                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  TRANSCRIPTION MODULATION IN ANIMALS USING CRISPR/CAS SYSTEMS

<130>  57766-527578

<150>  US 62/644,961
<151>  2018-03-19

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  1471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Ala Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Pro Lys Lys  Lys Arg Lys Val Ala  Ala Ala Gly 
    1400                 1405                 1410             


Ser Gly  Arg Ala Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1415                 1420                 1425             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1430                 1435                 1440             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala 
    1445                 1450                 1455             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Ile Asn Cys  Thr 
    1460                 1465                 1470     


<210>  2
<211>  1384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp 
    


<210>  3
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ala Ala Ala Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu 
1               5                   10                  15      


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
            20                  25                  30          


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
        35                  40                  45              


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Cys Thr 
    50                  55                  60          


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Gly Gly Ser 
1               


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gly Gly Gly Gly Ser 
1               5   


<210>  6
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Gly Ser 
145                 150                 155                 160 


Pro Ser Gly Gln Ile Ser Asn Gln Ala Leu Ala Leu Ala Pro Ser Ser 
                165                 170                 175     


Ala Pro Val Leu Ala Gln Thr Met Val Pro Ser Ser Ala Met Val Pro 
            180                 185                 190         


Leu Ala Gln Pro Pro Ala Pro Ala Pro Val Leu Thr Pro Gly Pro Pro 
        195                 200                 205             


Gln Ser Leu Ser Ala Pro Val Pro Lys Ser Thr Gln Ala Gly Glu Gly 
    210                 215                 220                 


Thr Leu Ser Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp 
225                 230                 235                 240 


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Gly Val Phe Thr Asp 
                245                 250                 255     


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
            260                 265                 270         


Val Ser Met Ser His Ser Thr Ala Glu Pro Met Leu Met Glu Tyr Pro 
        275                 280                 285             


Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro 
    290                 295                 300                 


Ala Pro Thr Pro Leu Gly Thr Ser Gly Leu Pro Asn Gly Leu Ser Gly 
305                 310                 315                 320 


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
                325                 330                 335     


Ser Gln Ile Ser Ser Ser Gly Gln Gly Gly Gly Gly Ser Gly Phe Ser 
            340                 345                 350         


Val Asp Thr Ser Ala Leu Leu Asp Leu Phe Ser Pro Ser Val Thr Val 
        355                 360                 365             


Pro Asp Met Ser Leu Pro Asp Leu Asp Ser Ser Leu Ala Ser Ile Gln 
    370                 375                 380                 


Glu Leu Leu Ser Pro Gln Glu Pro Pro Arg Pro Pro Glu Ala Glu Asn 
385                 390                 395                 400 


Ser Ser Pro Asp Ser Gly Lys Gln Leu Val His Tyr Thr Ala Gln Pro 
                405                 410                 415     


Leu Phe Leu Leu Asp Pro Gly Ser Val Asp Thr Gly Ser Asn Asp Leu 
            420                 425                 430         


Pro Val Leu Phe Glu Leu Gly Glu Gly Ser Tyr Phe Ser Glu Gly Asp 
        435                 440                 445             


Gly Phe Ala Glu Asp Pro Thr Ile Ser Leu Leu Thr Gly Ser Glu Pro 
    450                 455                 460                 


Pro Lys Ala Lys Asp Pro Thr Val Ser 
465                 470             


<210>  7
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210>  8
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Pro Ser Gly Gln Ile Ser Asn Gln Ala Leu Ala Leu Ala Pro Ser Ser 
1               5                   10                  15      


Ala Pro Val Leu Ala Gln Thr Met Val Pro Ser Ser Ala Met Val Pro 
            20                  25                  30          


Leu Ala Gln Pro Pro Ala Pro Ala Pro Val Leu Thr Pro Gly Pro Pro 
        35                  40                  45              


Gln Ser Leu Ser Ala Pro Val Pro Lys Ser Thr Gln Ala Gly Glu Gly 
    50                  55                  60                  


Thr Leu Ser Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp 
65                  70                  75                  80  


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Gly Val Phe Thr Asp 
                85                  90                  95      


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
            100                 105                 110         


Val Ser Met Ser His Ser Thr Ala Glu Pro Met Leu Met Glu Tyr Pro 
        115                 120                 125             


Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro 
    130                 135                 140                 


Ala Pro Thr Pro Leu Gly Thr Ser Gly Leu Pro Asn Gly Leu Ser Gly 
145                 150                 155                 160 


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
                165                 170                 175     


Ser Gln Ile Ser Ser 
            180     


<210>  9
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gly Phe Ser Val Asp Thr Ser Ala Leu Leu Asp Leu Phe Ser Pro Ser 
1               5                   10                  15      


Val Thr Val Pro Asp Met Ser Leu Pro Asp Leu Asp Ser Ser Leu Ala 
            20                  25                  30          


Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu Pro Pro Arg Pro Pro Glu 
        35                  40                  45              


Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys Gln Leu Val His Tyr Thr 
    50                  55                  60                  


Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly Ser Val Asp Thr Gly Ser 
65                  70                  75                  80  


Asn Asp Leu Pro Val Leu Phe Glu Leu Gly Glu Gly Ser Tyr Phe Ser 
                85                  90                  95      


Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr Ile Ser Leu Leu Thr Gly 
            100                 105                 110         


Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr Val Ser 
        115                 120                 


<210>  10
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
guuuuagagc uaugcu                                                       16


<210>  11
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  12
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcu                                                      77


<210>  13
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gc                                                82


<210>  14
<211>  76
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugc                                                       76


<210>  15
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugc                                            86


<210>  16
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
ggccaacaug aggaucaccc augucugcag ggcc                                   34


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  n = A, T, C, or G

<400>  17
gnnnnnnnnn nnnnnnnnnn ngg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  n = A, T, C, or G

<400>  18
nnnnnnnnnn nnnnnnnnnn ngg                                               23


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(23)
<223>  n = A, T, C, or G

<400>  19
ggnnnnnnnn nnnnnnnnnn nnngg                                             25


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  23
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  24
<211>  4152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggccat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg ac                                                         4152


<210>  25
<211>  4414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggccat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acagcgctgg aggaggtgga agcggaggag gaggaagcgg aggaggaggt     4200

agcggaccta agaaaaagag gaaggtggcg gccgctggat ccggacgggc tgacgcattg     4260

gacgattttg atctggatat gctgggaagt gacgccctcg atgattttga ccttgacatg     4320

cttggttcgg atgcccttga tgactttgac ctcgacatgc tcggcagtga cgcccttgat     4380

gatttcgacc tggacatgct gattaactgt acag                                 4414


<210>  26
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
atggcttcaa actttactca gttcgtgctc gtggacaatg gtgggacagg ggatgtgaca       60

gtggctcctt ctaatttcgc taatggggtg gcagagtgga tcagctccaa ctcacggagc      120

caggcctaca aggtgacatg cagcgtcagg cagtctagtg cccagaagag aaagtatacc      180

atcaaggtgg aggtccccaa agtggctacc cagacagtgg gcggagtcga actgcctgtc      240

gccgcttgga ggtcctacct gaacatggag ctcactatcc caattttcgc taccaattct      300

gactgtgaac tcatcgtgaa ggcaatgcag gggctcctca aagacggtaa tcctatccct      360

tccgccatcg ccgctaactc aggtatctac                                       390


<210>  27
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
atggcttcaa actttactca gttcgtgctc gtggacaatg gtgggacagg ggatgtgaca       60

gtggctcctt ctaatttcgc taatggggtg gcagagtgga tcagctccaa ctcacggagc      120

caggcctaca aggtgacatg cagcgtcagg cagtctagtg cccagaagag aaagtatacc      180

atcaaggtgg aggtccccaa agtggctacc cagacagtgg gcggagtcga actgcctgtc      240

gccgcttgga ggtcctacct gaacatggag ctcactatcc caattttcgc taccaattct      300

gactgtgaac tcatcgtgaa ggcaatgcag gggctcctca aagacggtaa tcctatccct      360

tccgccatcg ccgctaactc aggtatctac agcgctggag gaggtggaag cggaggagga      420

ggaagcggag gaggaggtag cggacctaag aaaaagagga aggtggcggc cgctggatcc      480

ccttcagggc agatcagcaa ccaggccctg gctctggccc ctagctccgc tccagtgctg      540

gcccagacta tggtgccctc tagtgctatg gtgcctctgg cccagccacc tgctccagcc      600

cctgtgctga ccccaggacc accccagtca ctgagcgctc cagtgcccaa gtctacacag      660

gccggcgagg ggactctgag tgaagctctg ctgcacctgc agttcgacgc tgatgaggac      720

ctgggagctc tgctggggaa cagcaccgat cccggagtgt tcacagatct ggcctccgtg      780

gacaactctg agtttcagca gctgctgaat cagggcgtgt ccatgtctca tagtacagcc      840

gaaccaatgc tgatggagta ccccgaagcc attacccggc tggtgaccgg cagccagcgg      900

ccccccgacc ccgctccaac tcccctggga accagcggcc tgcctaatgg gctgtccgga      960

gatgaagact tctcaagcat cgctgatatg gactttagtg ccctgctgtc acagatttcc     1020

tctagtgggc agggaggagg tggaagcggc ttcagcgtgg acaccagtgc cctgctggac     1080

ctgttcagcc cctcggtgac cgtgcccgac atgagcctgc ctgaccttga cagcagcctg     1140

gccagtatcc aagagctcct gtctccccag gagcccccca ggcctcccga ggcagagaac     1200

agcagcccgg attcagggaa gcagctggtg cactacacag cgcagccgct gttcctgctg     1260

gaccccggct ccgtggacac cgggagcaac gacctgccgg tgctgtttga gctgggagag     1320

ggctcctact tctccgaagg ggacggcttc gccgaggacc ccaccatctc cctgctgaca     1380

ggctcggagc ctcccaaagc caaggacccc actgtctcc                            1419


<210>  28
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
gcggccgctg gatccggacg ggctgacgca ttggacgatt ttgatctgga tatgctggga       60

agtgacgccc tcgatgattt tgaccttgac atgcttggtt cggatgccct tgatgacttt      120

gacctcgaca tgctcggcag tgacgccctt gatgatttcg acctggacat gctgattaac      180

tgtacag                                                                187


<210>  29
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
ccttcagggc agatcagcaa ccaggccctg gctctggccc ctagctccgc tccagtgctg       60

gcccagacta tggtgccctc tagtgctatg gtgcctctgg cccagccacc tgctccagcc      120

cctgtgctga ccccaggacc accccagtca ctgagcgctc cagtgcccaa gtctacacag      180

gccggcgagg ggactctgag tgaagctctg ctgcacctgc agttcgacgc tgatgaggac      240

ctgggagctc tgctggggaa cagcaccgat cccggagtgt tcacagatct ggcctccgtg      300

gacaactctg agtttcagca gctgctgaat cagggcgtgt ccatgtctca tagtacagcc      360

gaaccaatgc tgatggagta ccccgaagcc attacccggc tggtgaccgg cagccagcgg      420

ccccccgacc ccgctccaac tcccctggga accagcggcc tgcctaatgg gctgtccgga      480

gatgaagact tctcaagcat cgctgatatg gactttagtg ccctgctgtc acagatttcc      540

tct                                                                    543


<210>  30
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
ggcttcagcg tggacaccag tgccctgctg gacctgttca gcccctcggt gaccgtgccc       60

gacatgagcc tgcctgacct tgacagcagc ctggccagta tccaagagct cctgtctccc      120

caggagcccc ccaggcctcc cgaggcagag aacagcagcc cggattcagg gaagcagctg      180

gtgcactaca cagcgcagcc gctgttcctg ctggaccccg gctccgtgga caccgggagc      240

aacgacctgc cggtgctgtt tgagctggga gagggctcct acttctccga aggggacggc      300

ttcgccgagg accccaccat ctccctgctg acaggctcgg agcctcccaa agccaaggac      360

cccactgtct cc                                                          372


<210>  31
<211>  9043
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  First loxP site

<220>
<221>  misc_feature
<222>  (125)..(928)
<223>  Sequence encoding neomycin phosphotransferase for resistance to 
       neomycin family antibiotics

<220>
<221>  misc_feature
<222>  (937)..(2190)
<223>  Polyadenylation signal

<220>
<221>  misc_feature
<222>  (2218)..(2251)
<223>  Second loxP site

<220>
<221>  misc_feature
<222>  (2306)..(6457)
<223>  Codon-optimized dCas9 coding sequence

<220>
<221>  misc_feature
<222>  (2309)..(2356)
<223>  First NLS

<220>
<221>  misc_feature
<222>  (6512)..(6532)
<223>  Second NLS

<220>
<221>  misc_feature
<222>  (6533)..(6719)
<223>  VP64

<220>
<221>  misc_feature
<222>  (6719)..(6781)
<223>  T2A with 5' GSG

<220>
<221>  misc_feature
<222>  (6782)..(7171)
<223>  MCP

<220>
<221>  misc_feature
<222>  (7226)..(7246)
<223>  Third NLS

<220>
<221>  misc_feature
<222>  (7262)..(7804)
<223>  p65

<220>
<221>  misc_feature
<222>  (7829)..(8200)
<223>  HSF1

<220>
<221>  misc_feature
<222>  (8224)..(8820)
<223>  Woodchuck hepatitis virus posttranscriptional regulatory element 
       (WPRE)

<400>  31
ataacttcgt ataatgtatg ctatacgaag ttattaggtc cctcgacctg caggaattgt       60

tgacaattaa tcatcggcat agtatatcgg catagtataa tacgacaagg tgaggaacta      120

aaccatggga tcggccattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt      180

ggagaggcta ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt      240

gttccggctg tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc      300

cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc      360

ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga      420

agtgccgggg caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat      480

ggctgatgca atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca      540

agcgaaacat cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga      600

tgatctggac gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc      660

gcgcatgccc gacggcgatg atctcgtcgt gacccatggc gatgcctgct tgccgaatat      720

catggtggaa aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga      780

ccgctatcag gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg      840

ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt      900

ctatcgcctt cttgacgagt tcttctgagg ggatccgctg taagtctgca gaaattgatg      960

atctattaaa caataaagat gtccactaaa atggaagttt ttcctgtcat actttgttaa     1020

gaagggtgag aacagagtac ctacattttg aatggaagga ttggagctac gggggtgggg     1080

gtggggtggg attagataaa tgcctgctct ttactgaagg ctctttacta ttgctttatg     1140

ataatgtttc atagttggat atcataattt aaacaagcaa aaccaaatta agggccagct     1200

cattcctccc actcatgatc tatagatcta tagatctctc gtgggatcat tgtttttctc     1260

ttgattccca ctttgtggtt ctaagtactg tggtttccaa atgtgtcagt ttcatagcct     1320

gaagaacgag atcagcagcc tctgttccac atacacttca ttctcagtat tgttttgcca     1380

agttctaatt ccatcagaag cttgcagatc tgcgactcta gaggatctgc gactctagag     1440

gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca     1500

cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc     1560

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt     1620

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat     1680

ctgcgactct agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta     1740

aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt     1800

aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca     1860

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct     1920

tatcatgtct ggatctgcga ctctagagga tcataatcag ccataccaca tttgtagagg     1980

ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg     2040

caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca     2100

tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac     2160

tcatcaatgt atcttatcat gtctggatcc ccatcaagct gatccggaac ccttaatata     2220

acttcgtata atgtatgcta tacgaagtta ttaggtccct cgacctgcag cccaagctag     2280

tgcccgggaa ttcgctaggg ccaccatgaa aaggccggcg gccacgaaaa aggccggcca     2340

ggcaaaaaag aaaaaggaca agaagtacag catcggcctg gccatcggca ccaactctgt     2400

gggctgggcc gtgatcaccg acgagtacaa ggtgcccagc aagaaattca aggtgctggg     2460

caacaccgac cggcacagca tcaagaagaa cctgatcgga gccctgctgt tcgacagcgg     2520

cgaaacagcc gaggccaccc ggctgaagag aaccgccaga agaagataca ccagacggaa     2580

gaaccggatc tgctatctgc aagagatctt cagcaacgag atggccaagg tggacgacag     2640

cttcttccac agactggaag agtccttcct ggtggaagag gataagaagc acgagcggca     2700

ccccatcttc ggcaacatcg tggacgaggt ggcctaccac gagaagtacc ccaccatcta     2760

ccacctgaga aagaaactgg tggacagcac cgacaaggcc gacctgcggc tgatctatct     2820

ggccctggcc cacatgatca agttccgggg ccacttcctg atcgagggcg acctgaaccc     2880

cgacaacagc gacgtggaca agctgttcat ccagctggtg cagacctaca accagctgtt     2940

cgaggaaaac cccatcaacg ccagcggcgt ggacgccaag gccatcctgt ctgccagact     3000

gagcaagagc agacggctgg aaaatctgat cgcccagctg cccggcgaga agaagaatgg     3060

cctgttcggc aacctgattg ccctgagcct gggcctgacc cccaacttca agagcaactt     3120

cgacctggcc gaggatgcca aactgcagct gagcaaggac acctacgacg acgacctgga     3180

caacctgctg gcccagatcg gcgaccagta cgccgacctg tttctggccg ccaagaacct     3240

gtccgacgcc atcctgctga gcgacatcct gagagtgaac accgagatca ccaaggcccc     3300

cctgagcgcc tctatgatca agagatacga cgagcaccac caggacctga ccctgctgaa     3360

agctctcgtg cggcagcagc tgcctgagaa gtacaaagag attttcttcg accagagcaa     3420

gaacggctac gccggctaca ttgacggcgg agccagccag gaagagttct acaagttcat     3480

caagcccatc ctggaaaaga tggacggcac cgaggaactg ctcgtgaagc tgaacagaga     3540

ggacctgctg cggaagcagc ggaccttcga caacggcagc atcccccacc agatccacct     3600

gggagagctg cacgccattc tgcggcggca ggaagatttt tacccattcc tgaaggacaa     3660

ccgggaaaag atcgagaaga tcctgacctt ccgcatcccc tactacgtgg gccctctggc     3720

caggggaaac agcagattcg cctggatgac cagaaagagc gaggaaacca tcaccccctg     3780

gaacttcgag gaagtggtgg acaagggcgc ttccgcccag agcttcatcg agcggatgac     3840

caacttcgat aagaacctgc ccaacgagaa ggtgctgccc aagcacagcc tgctgtacga     3900

gtacttcacc gtgtataacg agctgaccaa agtgaaatac gtgaccgagg gaatgagaaa     3960

gcccgccttc ctgagcggcg agcagaaaaa ggccatcgtg gacctgctgt tcaagaccaa     4020

ccggaaagtg accgtgaagc agctgaaaga ggactacttc aagaaaatcg agtgcttcga     4080

ctccgtggaa atctccggcg tggaagatcg gttcaacgcc tccctgggca cataccacga     4140

tctgctgaaa attatcaagg acaaggactt cctggacaat gaggaaaacg aggacattct     4200

ggaagatatc gtgctgaccc tgacactgtt tgaggacaga gagatgatcg aggaacggct     4260

gaaaacctat gcccacctgt tcgacgacaa agtgatgaag cagctgaagc ggcggagata     4320

caccggctgg ggcaggctga gccggaagct gatcaacggc atccgggaca agcagtccgg     4380

caagacaatc ctggatttcc tgaagtccga cggcttcgcc aacagaaact tcatgcagct     4440

gatccacgac gacagcctga cctttaaaga ggacatccag aaagcccagg tgtccggcca     4500

gggcgatagc ctgcacgagc acattgccaa tctggccggc agccccgcca ttaagaaggg     4560

catcctgcag acagtgaagg tggtggacga gctcgtgaaa gtgatgggcc ggcacaagcc     4620

cgagaacatc gtgatcgaaa tggccagaga gaaccagacc acccagaagg gacagaagaa     4680

cagccgcgag agaatgaagc ggatcgaaga gggcatcaaa gagctgggca gccagatcct     4740

gaaagaacac cccgtggaaa acacccagct gcagaacgag aagctgtacc tgtactacct     4800

gcagaatggg cgggatatgt acgtggacca ggaactggac atcaaccggc tgtccgacta     4860

cgatgtggac cacatcgtgc ctcagagctt tctgaaggac gactccatcg acaacaaggt     4920

gctgaccaga agcgacaagg cccggggcaa gagcgacaac gtgccctccg aagaggtcgt     4980

gaagaagatg aagaactact ggcggcagct gctgaacgcc aagctgatta cccagagaaa     5040

gttcgacaat ctgaccaagg ccgagagagg cggcctgagc gaactggata aggccggctt     5100

catcaagaga cagctggtgg aaacccggca gatcacaaag cacgtggcac agatcctgga     5160

ctcccggatg aacactaagt acgacgagaa tgacaagctg atccgggaag tgaaagtgat     5220

caccctgaag tccaagctgg tgtccgattt ccggaaggat ttccagtttt acaaagtgcg     5280

cgagatcaac aactaccacc acgcccacga cgcctacctg aacgccgtcg tgggaaccgc     5340

cctgatcaaa aagtacccta agctggaaag cgagttcgtg tacggcgact acaaggtgta     5400

cgacgtgcgg aagatgatcg ccaagagcga gcaggaaatc ggcaaggcta ccgccaagta     5460

cttcttctac agcaacatca tgaacttttt caagaccgag attaccctgg ccaacggcga     5520

gatccggaag cggcctctga tcgagacaaa cggcgaaacc ggggagatcg tgtgggataa     5580

gggccgggat tttgccaccg tgcggaaagt gctgagcatg ccccaagtga atatcgtgaa     5640

aaagaccgag gtgcagacag gcggcttcag caaagagtct atcctgccca agaggaacag     5700

cgataagctg atcgccagaa agaaggactg ggaccctaag aagtacggcg gcttcgacag     5760

ccccaccgtg gcctattctg tgctggtggt ggccaaagtg gaaaagggca agtccaagaa     5820

actgaagagt gtgaaagagc tgctggggat caccatcatg gaaagaagca gcttcgagaa     5880

gaatcccatc gactttctgg aagccaaggg ctacaaagaa gtgaaaaagg acctgatcat     5940

caagctgcct aagtactccc tgttcgagct ggaaaacggc cggaagagaa tgctggcctc     6000

tgccggcgaa ctgcagaagg gaaacgaact ggccctgccc tccaaatatg tgaacttcct     6060

gtacctggcc agccactatg agaagctgaa gggctccccc gaggataatg agcagaaaca     6120

gctgtttgtg gaacagcaca agcactacct ggacgagatc atcgagcaga tcagcgagtt     6180

ctccaagaga gtgatcctgg ccgacgctaa tctggacaaa gtgctgtccg cctacaacaa     6240

gcaccgggat aagcccatca gagagcaggc cgagaatatc atccacctgt ttaccctgac     6300

caatctggga gcccctgccg ccttcaagta ctttgacacc accatcgacc ggaagaggta     6360

caccagcacc aaagaggtgc tggacgccac cctgatccac cagagcatca ccggcctgta     6420

cgagacacgg atcgacctgt ctcagctggg aggcgacagc gctggaggag gtggaagcgg     6480

aggaggagga agcggaggag gaggtagcgg acctaagaaa aagaggaagg tggcggccgc     6540

tggatccgga cgggctgacg cattggacga ttttgatctg gatatgctgg gaagtgacgc     6600

cctcgatgat tttgaccttg acatgcttgg ttcggatgcc cttgatgact ttgacctcga     6660

catgctcggc agtgacgccc ttgatgattt cgacctggac atgctgatta actgtacagg     6720

cagtggagag ggcagaggaa gtctgctaac atgcggtgac gtcgaggaga atcctggccc     6780

aatggcttca aactttactc agttcgtgct cgtggacaat ggtgggacag gggatgtgac     6840

agtggctcct tctaatttcg ctaatggggt ggcagagtgg atcagctcca actcacggag     6900

ccaggcctac aaggtgacat gcagcgtcag gcagtctagt gcccagaaga gaaagtatac     6960

catcaaggtg gaggtcccca aagtggctac ccagacagtg ggcggagtcg aactgcctgt     7020

cgccgcttgg aggtcctacc tgaacatgga gctcactatc ccaattttcg ctaccaattc     7080

tgactgtgaa ctcatcgtga aggcaatgca ggggctcctc aaagacggta atcctatccc     7140

ttccgccatc gccgctaact caggtatcta cagcgctgga ggaggtggaa gcggaggagg     7200

aggaagcgga ggaggaggta gcggacctaa gaaaaagagg aaggtggcgg ccgctggatc     7260

cccttcaggg cagatcagca accaggccct ggctctggcc cctagctccg ctccagtgct     7320

ggcccagact atggtgccct ctagtgctat ggtgcctctg gcccagccac ctgctccagc     7380

ccctgtgctg accccaggac caccccagtc actgagcgct ccagtgccca agtctacaca     7440

ggccggcgag gggactctga gtgaagctct gctgcacctg cagttcgacg ctgatgagga     7500

cctgggagct ctgctgggga acagcaccga tcccggagtg ttcacagatc tggcctccgt     7560

ggacaactct gagtttcagc agctgctgaa tcagggcgtg tccatgtctc atagtacagc     7620

cgaaccaatg ctgatggagt accccgaagc cattacccgg ctggtgaccg gcagccagcg     7680

gccccccgac cccgctccaa ctcccctggg aaccagcggc ctgcctaatg ggctgtccgg     7740

agatgaagac ttctcaagca tcgctgatat ggactttagt gccctgctgt cacagatttc     7800

ctctagtggg cagggaggag gtggaagcgg cttcagcgtg gacaccagtg ccctgctgga     7860

cctgttcagc ccctcggtga ccgtgcccga catgagcctg cctgaccttg acagcagcct     7920

ggccagtatc caagagctcc tgtctcccca ggagcccccc aggcctcccg aggcagagaa     7980

cagcagcccg gattcaggga agcagctggt gcactacaca gcgcagccgc tgttcctgct     8040

ggaccccggc tccgtggaca ccgggagcaa cgacctgccg gtgctgtttg agctgggaga     8100

gggctcctac ttctccgaag gggacggctt cgccgaggac cccaccatct ccctgctgac     8160

aggctcggag cctcccaaag ccaaggaccc cactgtctcc tgagaattcg atatcaagct     8220

tatcgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     8280

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     8340

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     8400

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     8460

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     8520

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     8580

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg     8640

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     8700

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     8760

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcatcg     8820

ataccgtcga cctcgacctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     8880

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     8940

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     9000

caggacagca agggggagga ttgggaagac aatggcaggc atg                       9043


<210>  32
<211>  3812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  First rox site

<220>
<221>  misc_feature
<222>  (111)..(710)
<223>  Sequence encoding puromycin-N-acetyltransferase for resistance to
       puromycin family antibiotics

<220>
<221>  misc_feature
<222>  (797)..(2338)
<223>  Polyadenylation signal

<220>
<221>  misc_feature
<222>  (2363)..(2394)
<223>  Second rox site

<220>
<221>  misc_feature
<222>  (2401)..(2640)
<223>  First U6 promoter

<220>
<221>  misc_feature
<222>  (2641)..(2797)
<223>  First guide RNA coding sequence

<220>
<221>  misc_feature
<222>  (2641)..(2660)
<223>  n = A, T, C, or G

<220>
<221>  misc_feature
<222>  (2883)..(3122)
<223>  Second U6 promoter

<220>
<221>  misc_feature
<222>  (3123)..(3279)
<223>  Second guide RNA coding sequence

<220>
<221>  misc_feature
<222>  (3123)..(3142)
<223>  n = A, T, C, or G

<220>
<221>  misc_feature
<222>  (3364)..(3603)
<223>  Third U6 promoter

<220>
<221>  misc_feature
<222>  (3604)..(3760)
<223>  Third guide RNA coding sequence

<220>
<221>  misc_feature
<222>  (3604)..(3623)
<223>  n = A, T, C, or G

<400>  32
taactttaaa taatgccaat tatttaaagt tacctgcagg acgtgttgac aattaatcat       60

cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc atgaccgagt      120

acaagcccac ggtgcgcctc gccacccgcg acgacgtccc cagggccgta cgcaccctcg      180

ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccggac cgccacatcg      240

agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac atcggcaagg      300

tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag agcgtcgaag      360

cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt tcccggctgg      420

ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag cccgcgtggt      480

tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc agcgccgtcg      540

tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg gagacctccg      600

cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc gacgtcgagg      660

tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga cgcccgcccc      720

acgacccgca gcgcccgacc gaaaggagcg cacgacccca tgcatcgatg atctagagct      780

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc      840

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      900

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      960

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     1020

gcataacttc gtataatgta tgctatacgg gggatccgct gtaagtctgc agaaattgat     1080

gatctattaa acaataaaga tgtccactaa aatggaagtt tttcctgtca tactttgtta     1140

agaagggtga gaacagagta cctacatttt gaatggaagg attggagcta cgggggtggg     1200

ggtggggtgg gattagataa atgcctgctc tttactgaag gctctttact attgctttat     1260

gataatgttt catagttgga tatcataatt taaacaagca aaaccaaatt aagggccagc     1320

tcattcctcc cactcatgat ctatagatct atagatctct cgtgggatca ttgtttttct     1380

cttgattccc actttgtggt tctaagtact gtggtttcca aatgtgtcag tttcatagcc     1440

tgaagaacga gatcagcagc ctctgttcca catacacttc attctcagta ttgttttgcc     1500

aagttctaat tccatcagac ctcgacctgc agccgacgct aggtcgtcag tcaaagtacg     1560

tacctcaggt gcaggctgcc tatcagaagg tggtggctgg tgtggccaat gccctggctc     1620

acaaatacca ctgagatctt tttccctctg ccaaaaatta tggggacatc atgaagcccc     1680

ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata gtgtgttgga     1740

attttttgtg tctctcactc ggaaggacat atgggagggc aaatcattta aaacatcaga     1800

atgagtattt ggtttagagt ttggcaacat atgcccatat gctggctgcc atgaacaaag     1860

gttggctata aagaggtcat cagtatatga aacagccccc tgctgtccat tccttattcc     1920

atagaaaagc cttgacttga ggttagattt tttttatatt ttgttttgtg ttattttttt     1980

ctttaacatc cctaaaattt tccttagatg ttttactagc cagatttttc ctcctctcct     2040

gactactccc agtcatagct gtccctcttc tcttatggag atccctcgag gacatgaggt     2100

cgtcgctgta atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     2160

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat     2220

tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt     2280

tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtcga     2340

cactgggtcg tgatcgggta cctaacttta aataatgcca attatttaaa gttagctagc     2400

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga     2460

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa     2520

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc     2580

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc     2640

nnnnnnnnnn nnnnnnnnnn gttttagagc taggccaaca tgaggatcac ccatgtctgc     2700

agggcctagc aagttaaaat aaggctagtc cgttatcaac ttggccaaca tgaggatcac     2760

ccatgtctgc agggccaagt ggcaccgagt cggtgctttt tttgttttag agctagaaat     2820

agcaagttaa aataaggcta gtccgttttg agctccataa gactcggcct tagaacaagc     2880

tttttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg     2940

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     3000

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     3060

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     3120

ccnnnnnnnn nnnnnnnnnn nngttttaga gctaggccaa catgaggatc acccatgtct     3180

gcagggccta gcaagttaaa ataaggctag tccgttatca acttggccaa catgaggatc     3240

acccatgtct gcagggccaa gtggcaccga gtcggtgctt tttttgtttt agagctagaa     3300

atagcaagtt aaaataaggc tagtccgttt tatgcatgtg gctcccattt atacctggcc     3360

ggctttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     3420

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     3480

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     3540

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     3600

accnnnnnnn nnnnnnnnnn nnngttttag agctaggcca acatgaggat cacccatgtc     3660

tgcagggcct agcaagttaa aataaggcta gtccgttatc aacttggcca acatgaggat     3720

cacccatgtc tgcagggcca agtggcaccg agtcggtgct ttttttgttt tagagctaga     3780

aatagcaagt taaaataagg ctagtccgtt tt                                   3812


<210>  33
<211>  3814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  First rox site

<220>
<221>  misc_feature
<222>  (111)..(710)
<223>  Sequence encoding puromycin-N-acetyltransferase for resistance to
       puromycin family antibiotics

<220>
<221>  misc_feature
<222>  (797)..(2338)
<223>  Polyadenylation signal

<220>
<221>  misc_feature
<222>  (2363)..(2394)
<223>  Second rox site

<220>
<221>  misc_feature
<222>  (2401)..(2640)
<223>  First U6 promoter

<220>
<221>  misc_feature
<222>  (2642)..(2798)
<223>  First Ttr guide RNA coding sequence

<220>
<221>  misc_feature
<222>  (2884)..(3123)
<223>  Second U6 promoter

<220>
<221>  misc_feature
<222>  (3125)..(3281)
<223>  Second Ttr guide RNA coding sequence

<220>
<221>  misc_feature
<222>  (3366)..(3605)
<223>  Third U6 promoter

<220>
<221>  misc_feature
<222>  (3606)..(3762)
<223>  Third Ttr guide RNA coding sequence

<400>  33
taactttaaa taatgccaat tatttaaagt tacctgcagg acgtgttgac aattaatcat       60

cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc atgaccgagt      120

acaagcccac ggtgcgcctc gccacccgcg acgacgtccc cagggccgta cgcaccctcg      180

ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccggac cgccacatcg      240

agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac atcggcaagg      300

tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag agcgtcgaag      360

cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt tcccggctgg      420

ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag cccgcgtggt      480

tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc agcgccgtcg      540

tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg gagacctccg      600

cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc gacgtcgagg      660

tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga cgcccgcccc      720

acgacccgca gcgcccgacc gaaaggagcg cacgacccca tgcatcgatg atctagagct      780

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc      840

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      900

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      960

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     1020

gcataacttc gtataatgta tgctatacgg gggatccgct gtaagtctgc agaaattgat     1080

gatctattaa acaataaaga tgtccactaa aatggaagtt tttcctgtca tactttgtta     1140

agaagggtga gaacagagta cctacatttt gaatggaagg attggagcta cgggggtggg     1200

ggtggggtgg gattagataa atgcctgctc tttactgaag gctctttact attgctttat     1260

gataatgttt catagttgga tatcataatt taaacaagca aaaccaaatt aagggccagc     1320

tcattcctcc cactcatgat ctatagatct atagatctct cgtgggatca ttgtttttct     1380

cttgattccc actttgtggt tctaagtact gtggtttcca aatgtgtcag tttcatagcc     1440

tgaagaacga gatcagcagc ctctgttcca catacacttc attctcagta ttgttttgcc     1500

aagttctaat tccatcagac ctcgacctgc agccgacgct aggtcgtcag tcaaagtacg     1560

tacctcaggt gcaggctgcc tatcagaagg tggtggctgg tgtggccaat gccctggctc     1620

acaaatacca ctgagatctt tttccctctg ccaaaaatta tggggacatc atgaagcccc     1680

ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata gtgtgttgga     1740

attttttgtg tctctcactc ggaaggacat atgggagggc aaatcattta aaacatcaga     1800

atgagtattt ggtttagagt ttggcaacat atgcccatat gctggctgcc atgaacaaag     1860

gttggctata aagaggtcat cagtatatga aacagccccc tgctgtccat tccttattcc     1920

atagaaaagc cttgacttga ggttagattt tttttatatt ttgttttgtg ttattttttt     1980

ctttaacatc cctaaaattt tccttagatg ttttactagc cagatttttc ctcctctcct     2040

gactactccc agtcatagct gtccctcttc tcttatggag atccctcgag gacatgaggt     2100

cgtcgctgta atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     2160

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat     2220

tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt     2280

tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtcga     2340

cactgggtcg tgatcgggta cctaacttta aataatgcca attatttaaa gttagctagc     2400

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga     2460

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa     2520

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc     2580

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc     2640

gacggttgcc ctctttccca agttttagag ctaggccaac atgaggatca cccatgtctg     2700

cagggcctag caagttaaaa taaggctagt ccgttatcaa cttggccaac atgaggatca     2760

cccatgtctg cagggccaag tggcaccgag tcggtgcttt ttttgtttta gagctagaaa     2820

tagcaagtta aaataaggct agtccgtttt gagctccata agactcggcc ttagaacaag     2880

ctttttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     2940

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     3000

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     3060

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     3120

accgactgtc agactcaaag gtgcgtttta gagctaggcc aacatgagga tcacccatgt     3180

ctgcagggcc tagcaagtta aaataaggct agtccgttat caacttggcc aacatgagga     3240

tcacccatgt ctgcagggcc aagtggcacc gagtcggtgc tttttttgtt ttagagctag     3300

aaatagcaag ttaaaataag gctagtccgt tttatgcatg tggctcccat ttatacctgg     3360

ccggctttcc catgattcct tcatatttgc atatacgata caaggctgtt agagagataa     3420

ttggaattaa tttgactgta aacacaaaga tattagtaca aaatacgtga cgtagaaagt     3480

aataatttct tgggtagttt gcagttttaa aattatgttt taaaatggac tatcatatgc     3540

ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg aaaggacgaa     3600

acaccgacaa taagtagtct tactcgtttt agagctaggc caacatgagg atcacccatg     3660

tctgcagggc ctagcaagtt aaaataaggc tagtccgtta tcaacttggc caacatgagg     3720

atcacccatg tctgcagggc caagtggcac cgagtcggtg ctttttttgt tttagagcta     3780

gaaatagcaa gttaaaataa ggctagtccg tttt                                 3814


<210>  34
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  34
acggttgccc tctttcccaa                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  35
actgtcagac tcaaaggtgc                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  36
gacaataagt agtcttactc                                                   20


<210>  37
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
acgguugccc ucuuucccaa guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  38
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
acugucagac ucaaaggugc guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  39
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
gacaauaagu agucuuacuc guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  40
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
guuuuagagc uaggccaaca ugaggaucac ccaugucugc agggccuagc aaguuaaaau       60

aaggcuaguc cguuaucaac uuggccaaca ugaggaucac ccaugucugc agggccaagu      120

ggcaccgagu cggugcu                                                     137


<210>  41
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
acgguugccc ucuuucccaa                                                   20


<210>  42
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
acugucagac ucaaaggugc                                                   20


<210>  43
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
gacaauaagu agucuuacuc                                                   20


<210>  44
<211>  1965
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Ala Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Pro Lys Lys  Lys Arg Lys Val Ala  Ala Ala Gly 
    1400                 1405                 1410             


Ser Gly  Arg Ala Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1415                 1420                 1425             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1430                 1435                 1440             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala 
    1445                 1450                 1455             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Ile Asn Cys  Thr Gly Ser 
    1460                 1465                 1470             


Gly Glu  Gly Arg Gly Ser Leu  Leu Thr Cys Gly Asp  Val Glu Glu 
    1475                 1480                 1485             


Asn Pro  Gly Pro Met Ala Ser  Asn Phe Thr Gln Phe  Val Leu Val 
    1490                 1495                 1500             


Asp Asn  Gly Gly Thr Gly Asp  Val Thr Val Ala Pro  Ser Asn Phe 
    1505                 1510                 1515             


Ala Asn  Gly Val Ala Glu Trp  Ile Ser Ser Asn Ser  Arg Ser Gln 
    1520                 1525                 1530             


Ala Tyr  Lys Val Thr Cys Ser  Val Arg Gln Ser Ser  Ala Gln Lys 
    1535                 1540                 1545             


Arg Lys  Tyr Thr Ile Lys Val  Glu Val Pro Lys Val  Ala Thr Gln 
    1550                 1555                 1560             


Thr Val  Gly Gly Val Glu Leu  Pro Val Ala Ala Trp  Arg Ser Tyr 
    1565                 1570                 1575             


Leu Asn  Met Glu Leu Thr Ile  Pro Ile Phe Ala Thr  Asn Ser Asp 
    1580                 1585                 1590             


Cys Glu  Leu Ile Val Lys Ala  Met Gln Gly Leu Leu  Lys Asp Gly 
    1595                 1600                 1605             


Asn Pro  Ile Pro Ser Ala Ile  Ala Ala Asn Ser Gly  Ile Tyr Ser 
    1610                 1615                 1620             


Ala Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1625                 1630                 1635             


Ser Gly  Pro Lys Lys Lys Arg  Lys Val Ala Ala Ala  Gly Ser Pro 
    1640                 1645                 1650             


Ser Gly  Gln Ile Ser Asn Gln  Ala Leu Ala Leu Ala  Pro Ser Ser 
    1655                 1660                 1665             


Ala Pro  Val Leu Ala Gln Thr  Met Val Pro Ser Ser  Ala Met Val 
    1670                 1675                 1680             


Pro Leu  Ala Gln Pro Pro Ala  Pro Ala Pro Val Leu  Thr Pro Gly 
    1685                 1690                 1695             


Pro Pro  Gln Ser Leu Ser Ala  Pro Val Pro Lys Ser  Thr Gln Ala 
    1700                 1705                 1710             


Gly Glu  Gly Thr Leu Ser Glu  Ala Leu Leu His Leu  Gln Phe Asp 
    1715                 1720                 1725             


Ala Asp  Glu Asp Leu Gly Ala  Leu Leu Gly Asn Ser  Thr Asp Pro 
    1730                 1735                 1740             


Gly Val  Phe Thr Asp Leu Ala  Ser Val Asp Asn Ser  Glu Phe Gln 
    1745                 1750                 1755             


Gln Leu  Leu Asn Gln Gly Val  Ser Met Ser His Ser  Thr Ala Glu 
    1760                 1765                 1770             


Pro Met  Leu Met Glu Tyr Pro  Glu Ala Ile Thr Arg  Leu Val Thr 
    1775                 1780                 1785             


Gly Ser  Gln Arg Pro Pro Asp  Pro Ala Pro Thr Pro  Leu Gly Thr 
    1790                 1795                 1800             


Ser Gly  Leu Pro Asn Gly Leu  Ser Gly Asp Glu Asp  Phe Ser Ser 
    1805                 1810                 1815             


Ile Ala  Asp Met Asp Phe Ser  Ala Leu Leu Ser Gln  Ile Ser Ser 
    1820                 1825                 1830             


Ser Gly  Gln Gly Gly Gly Gly  Ser Gly Phe Ser Val  Asp Thr Ser 
    1835                 1840                 1845             


Ala Leu  Leu Asp Leu Phe Ser  Pro Ser Val Thr Val  Pro Asp Met 
    1850                 1855                 1860             


Ser Leu  Pro Asp Leu Asp Ser  Ser Leu Ala Ser Ile  Gln Glu Leu 
    1865                 1870                 1875             


Leu Ser  Pro Gln Glu Pro Pro  Arg Pro Pro Glu Ala  Glu Asn Ser 
    1880                 1885                 1890             


Ser Pro  Asp Ser Gly Lys Gln  Leu Val His Tyr Thr  Ala Gln Pro 
    1895                 1900                 1905             


Leu Phe  Leu Leu Asp Pro Gly  Ser Val Asp Thr Gly  Ser Asn Asp 
    1910                 1915                 1920             


Leu Pro  Val Leu Phe Glu Leu  Gly Glu Gly Ser Tyr  Phe Ser Glu 
    1925                 1930                 1935             


Gly Asp  Gly Phe Ala Glu Asp  Pro Thr Ile Ser Leu  Leu Thr Gly 
    1940                 1945                 1950             


Ser Glu  Pro Pro Lys Ala Lys  Asp Pro Thr Val Ser  
    1955                 1960                 1965 


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
cgtgatctgc aactccagtc tt                                                22


<210>  46
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
agatgggcgg gagtcttctg ggc                                               23


<210>  47
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
cacaccaggt tagcctttaa gcc                                               23


<210>  48
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
ggtggagagg ctattcggc                                                    19


<210>  49
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
tgggcacaac agacaatcgg ctg                                               23


<210>  50
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
gaacacggcg gcatcag                                                      17


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
accggctgtc cgactacgat                                                   20


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
tggaccacat cgtgcctcag a                                                 21


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
cgggccttgt cgcttctg                                                     18


<210>  54
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
ggctccttct aatttcgcta atgg                                              24


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
tggcagagtg gatcagctcc a                                                 21


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
ctgacgctgc atgtcacctt                                                   20


<210>  57
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
agggcgtgtc catgtctcat ag                                                22


<210>  58
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
acagccgaac caatgctgat gga                                               23


<210>  59
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
ccagccgggt aatggcttc                                                    19


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
tgtgttgcca cctggattct g                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
cgcgggacgt ccttctgcta c                                                 21


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
ggaaggtccg ctggattgag                                                   20


<210>  63
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n = A, T, C, or G

<400>  63
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  64
<211>  5895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggccat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acagcgctgg aggaggtgga agcggaggag gaggaagcgg aggaggaggt     4200

agcggaccta agaaaaagag gaaggtggcg gccgctggat ccggacgggc tgacgcattg     4260

gacgattttg atctggatat gctgggaagt gacgccctcg atgattttga ccttgacatg     4320

cttggttcgg atgcccttga tgactttgac ctcgacatgc tcggcagtga cgcccttgat     4380

gatttcgacc tggacatgct gattaactgt acaggcagtg gagagggcag aggaagtctg     4440

ctaacatgcg gtgacgtcga ggagaatcct ggcccaatgg cttcaaactt tactcagttc     4500

gtgctcgtgg acaatggtgg gacaggggat gtgacagtgg ctccttctaa tttcgctaat     4560

ggggtggcag agtggatcag ctccaactca cggagccagg cctacaaggt gacatgcagc     4620

gtcaggcagt ctagtgccca gaagagaaag tataccatca aggtggaggt ccccaaagtg     4680

gctacccaga cagtgggcgg agtcgaactg cctgtcgccg cttggaggtc ctacctgaac     4740

atggagctca ctatcccaat tttcgctacc aattctgact gtgaactcat cgtgaaggca     4800

atgcaggggc tcctcaaaga cggtaatcct atcccttccg ccatcgccgc taactcaggt     4860

atctacagcg ctggaggagg tggaagcgga ggaggaggaa gcggaggagg aggtagcgga     4920

cctaagaaaa agaggaaggt ggcggccgct ggatcccctt cagggcagat cagcaaccag     4980

gccctggctc tggcccctag ctccgctcca gtgctggccc agactatggt gccctctagt     5040

gctatggtgc ctctggccca gccacctgct ccagcccctg tgctgacccc aggaccaccc     5100

cagtcactga gcgctccagt gcccaagtct acacaggccg gcgaggggac tctgagtgaa     5160

gctctgctgc acctgcagtt cgacgctgat gaggacctgg gagctctgct ggggaacagc     5220

accgatcccg gagtgttcac agatctggcc tccgtggaca actctgagtt tcagcagctg     5280

ctgaatcagg gcgtgtccat gtctcatagt acagccgaac caatgctgat ggagtacccc     5340

gaagccatta cccggctggt gaccggcagc cagcggcccc ccgaccccgc tccaactccc     5400

ctgggaacca gcggcctgcc taatgggctg tccggagatg aagacttctc aagcatcgct     5460

gatatggact ttagtgccct gctgtcacag atttcctcta gtgggcaggg aggaggtgga     5520

agcggcttca gcgtggacac cagtgccctg ctggacctgt tcagcccctc ggtgaccgtg     5580

cccgacatga gcctgcctga ccttgacagc agcctggcca gtatccaaga gctcctgtct     5640

ccccaggagc cccccaggcc tcccgaggca gagaacagca gcccggattc agggaagcag     5700

ctggtgcact acacagcgca gccgctgttc ctgctggacc ccggctccgt ggacaccggg     5760

agcaacgacc tgccggtgct gtttgagctg ggagagggct cctacttctc cgaaggggac     5820

ggcttcgccg aggaccccac catctccctg ctgacaggct cggagcctcc caaagccaag     5880

gaccccactg tctcc                                                      5895


<210>  65
<211>  1412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (241)..(260)
<223>  n = A, T, C, or G

<220>
<221>  misc_feature
<222>  (723)..(742)
<223>  n = A, T, C, or G

<220>
<221>  misc_feature
<222>  (1204)..(1223)
<223>  n = A, T, C, or G

<400>  65
tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga       60

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      120

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      180

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      240

nnnnnnnnnn nnnnnnnnnn gttttagagc taggccaaca tgaggatcac ccatgtctgc      300

agggcctagc aagttaaaat aaggctagtc cgttatcaac ttggccaaca tgaggatcac      360

ccatgtctgc agggccaagt ggcaccgagt cggtgctttt tttgttttag agctagaaat      420

agcaagttaa aataaggcta gtccgttttg agctccataa gactcggcct tagaacaagc      480

tttttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg      540

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat      600

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta      660

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca      720

ccnnnnnnnn nnnnnnnnnn nngttttaga gctaggccaa catgaggatc acccatgtct      780

gcagggccta gcaagttaaa ataaggctag tccgttatca acttggccaa catgaggatc      840

acccatgtct gcagggccaa gtggcaccga gtcggtgctt tttttgtttt agagctagaa      900

atagcaagtt aaaataaggc tagtccgttt tatgcatgtg gctcccattt atacctggcc      960

ggctttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     1020

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     1080

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     1140

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     1200

accnnnnnnn nnnnnnnnnn nnngttttag agctaggcca acatgaggat cacccatgtc     1260

tgcagggcct agcaagttaa aataaggcta gtccgttatc aacttggcca acatgaggat     1320

cacccatgtc tgcagggcca agtggcaccg agtcggtgct ttttttgttt tagagctaga     1380

aatagcaagt taaaataagg ctagtccgtt tt                                   1412


<210>  66
<211>  1414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga       60

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      120

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      180

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      240

gacggttgcc ctctttccca agttttagag ctaggccaac atgaggatca cccatgtctg      300

cagggcctag caagttaaaa taaggctagt ccgttatcaa cttggccaac atgaggatca      360

cccatgtctg cagggccaag tggcaccgag tcggtgcttt ttttgtttta gagctagaaa      420

tagcaagtta aaataaggct agtccgtttt gagctccata agactcggcc ttagaacaag      480

ctttttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt      540

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa      600

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt      660

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac      720

accgactgtc agactcaaag gtgcgtttta gagctaggcc aacatgagga tcacccatgt      780

ctgcagggcc tagcaagtta aaataaggct agtccgttat caacttggcc aacatgagga      840

tcacccatgt ctgcagggcc aagtggcacc gagtcggtgc tttttttgtt ttagagctag      900

aaatagcaag ttaaaataag gctagtccgt tttatgcatg tggctcccat ttatacctgg      960

ccggctttcc catgattcct tcatatttgc atatacgata caaggctgtt agagagataa     1020

ttggaattaa tttgactgta aacacaaaga tattagtaca aaatacgtga cgtagaaagt     1080

aataatttct tgggtagttt gcagttttaa aattatgttt taaaatggac tatcatatgc     1140

ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg aaaggacgaa     1200

acaccgacaa taagtagtct tactcgtttt agagctaggc caacatgagg atcacccatg     1260

tctgcagggc ctagcaagtt aaaataaggc tagtccgtta tcaacttggc caacatgagg     1320

atcacccatg tctgcagggc caagtggcac cgagtcggtg ctttttttgt tttagagcta     1380

gaaatagcaa gttaaaataa ggctagtccg tttt                                 1414


<210>  67
<211>  1490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (28)..(267)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (269)..(288)
<223>  Guide1

<220>
<221>  misc_feature
<222>  (289)..(425)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (426)..(477)
<223>  Extended terminator

<220>
<221>  misc_feature
<222>  (511)..(750)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (752)..(771)
<223>  Guide2

<220>
<221>  misc_feature
<222>  (772)..(908)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (909)..(960)
<223>  Extended terminator

<220>
<221>  misc_feature
<222>  (993)..(1232)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (1233)..(1252)
<223>  Guide3

<220>
<221>  misc_feature
<222>  (1253)..(1389)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (1390)..(1441)
<223>  Extended terminator

<400>  67
gctagccata agactcggcc ttagaacttt cccatgattc cttcatattt gcatatacga       60

tacaaggctg ttagagagat aattggaatt aatttgactg taaacacaaa gatattagta      120

caaaatacgt gacgtagaaa gtaataattt cttgggtagt ttgcagtttt aaaattatgt      180

tttaaaatgg actatcatat gcttaccgta acttgaaagt atttcgattt cttggcttta      240

tatatcttgt ggaaaggacg aaacaccgac ggttgccctc tttcccaagt tttagagcta      300

ggccaacatg aggatcaccc atgtctgcag ggcctagcaa gttaaaataa ggctagtccg      360

ttatcaactt ggccaacatg aggatcaccc atgtctgcag ggccaagtgg caccgagtcg      420

gtgctttttt tgttttagag ctagaaatag caagttaaaa taaggctagt ccgttttgag      480

ctccataaga ctcggcctta gaacaagctt tttcccatga ttccttcata tttgcatata      540

cgatacaagg ctgttagaga gataattgga attaatttga ctgtaaacac aaagatatta      600

gtacaaaata cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta      660

tgttttaaaa tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct      720

ttatatatct tgtggaaagg acgaaacacc gactgtcaga ctcaaaggtg cgttttagag      780

ctaggccaac atgaggatca cccatgtctg cagggcctag caagttaaaa taaggctagt      840

ccgttatcaa cttggccaac atgaggatca cccatgtctg cagggccaag tggcaccgag      900

tcggtgcttt ttttgtttta gagctagaaa tagcaagtta aaataaggct agtccgtttt      960

atgcatgtgg ctcccattta tacctggccg gctttcccat gattccttca tatttgcata     1020

tacgatacaa ggctgttaga gagataattg gaattaattt gactgtaaac acaaagatat     1080

tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg gtagtttgca gttttaaaat     1140

tatgttttaa aatggactat catatgctta ccgtaacttg aaagtatttc gatttcttgg     1200

ctttatatat cttgtggaaa ggacgaaaca ccgacaataa gtagtcttac tcgttttaga     1260

gctaggccaa catgaggatc acccatgtct gcagggccta gcaagttaaa ataaggctag     1320

tccgttatca acttggccaa catgaggatc acccatgtct gcagggccaa gtggcaccga     1380

gtcggtgctt tttttgtttt agagctagaa atagcaagtt aaaataaggc tagtccgttt     1440

tggtcaccca gtgaggaagc taggacagac ctaggacggt tgcctgcagg                1490


<210>  68
<211>  490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (320)..(339)
<223>  Guide1

<220>
<221>  misc_feature
<222>  (340)..(476)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (477)..(482)
<223>  Small terminator

<400>  68
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga cggttgccct ctttcccaag ttttagagct aggccaacat      360

gaggatcacc catgtctgca gggcctagca agttaaaata aggctagtcc gttatcaact      420

tggccaacat gaggatcacc catgtctgca gggccaagtg gcaccgagtc ggtgcttttt      480

ttctagaggc                                                             490


<210>  69
<211>  490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (320)..(339)
<223>  Guide2

<220>
<221>  misc_feature
<222>  (340)..(476)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (477)..(482)
<223>  Small terminator

<400>  69
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga ctgtcagact caaaggtgcg ttttagagct aggccaacat      360

gaggatcacc catgtctgca gggcctagca agttaaaata aggctagtcc gttatcaact      420

tggccaacat gaggatcacc catgtctgca gggccaagtg gcaccgagtc ggtgcttttt      480

ttctagaggc                                                             490


<210>  70
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (319)..(338)
<223>  Guide3

<220>
<221>  misc_feature
<222>  (339)..(475)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (476)..(481)
<223>  Small terminator

<400>  70
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga caataagtag tcttactcgt tttagagcta ggccaacatg      360

aggatcaccc atgtctgcag ggcctagcaa gttaaaataa ggctagtccg ttatcaactt      420

ggccaacatg aggatcaccc atgtctgcag ggccaagtgg caccgagtcg gtgctttttt      480

tctagaggc                                                              489


<210>  71
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (28)..(267)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (269)..(288)
<223>  Guide1

<220>
<221>  misc_feature
<222>  (289)..(425)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (426)..(477)
<223>  Extended terminator

<220>
<221>  misc_feature
<222>  (511)..(750)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (752)..(771)
<223>  Guide2

<220>
<221>  misc_feature
<222>  (772)..(908)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (909)..(960)
<223>  Extended terminator

<220>
<221>  misc_feature
<222>  (993)..(1232)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (1234)..(1253)
<223>  Guide3

<220>
<221>  misc_feature
<222>  (1254)..(1390)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (1391)..(1442)
<223>  Extended terminator

<400>  71
gctagccata agactcggcc ttagaacttt cccatgattc cttcatattt gcatatacga       60

tacaaggctg ttagagagat aattggaatt aatttgactg taaacacaaa gatattagta      120

caaaatacgt gacgtagaaa gtaataattt cttgggtagt ttgcagtttt aaaattatgt      180

tttaaaatgg actatcatat gcttaccgta acttgaaagt atttcgattt cttggcttta      240

tatatcttgt ggaaaggacg aaacaccgaa gcggtgaaat tctgtggggt tttagagcta      300

ggccaacatg aggatcaccc atgtctgcag ggcctagcaa gttaaaataa ggctagtccg      360

ttatcaactt ggccaacatg aggatcaccc atgtctgcag ggccaagtgg caccgagtcg      420

gtgctttttt tgttttagag ctagaaatag caagttaaaa taaggctagt ccgttttgag      480

ctccataaga ctcggcctta gaacaagctt tttcccatga ttccttcata tttgcatata      540

cgatacaagg ctgttagaga gataattgga attaatttga ctgtaaacac aaagatatta      600

gtacaaaata cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta      660

tgttttaaaa tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct      720

ttatatatct tgtggaaagg acgaaacacc gcactcaaac agcaacgcgg ggttttagag      780

ctaggccaac atgaggatca cccatgtctg cagggcctag caagttaaaa taaggctagt      840

ccgttatcaa cttggccaac atgaggatca cccatgtctg cagggccaag tggcaccgag      900

tcggtgcttt ttttgtttta gagctagaaa tagcaagtta aaataaggct agtccgtttt      960

atgcatgtgg ctcccattta tacctggccg gctttcccat gattccttca tatttgcata     1020

tacgatacaa ggctgttaga gagataattg gaattaattt gactgtaaac acaaagatat     1080

tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg gtagtttgca gttttaaaat     1140

tatgttttaa aatggactat catatgctta ccgtaacttg aaagtatttc gatttcttgg     1200

ctttatatat cttgtggaaa ggacgaaaca ccgcttcacc tcactgagcg ggggttttag     1260

agctaggcca acatgaggat cacccatgtc tgcagggcct agcaagttaa aataaggcta     1320

gtccgttatc aacttggcca acatgaggat cacccatgtc tgcagggcca agtggcaccg     1380

agtcggtgct ttttttgttt tagagctaga aatagcaagt taaaataagg ctagtccgtt     1440

ttggtcaccc agtgaggaag ctaggacaga cctaggacgg ttgcctgcag g              1491


<210>  72
<211>  490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (320)..(339)
<223>  Guide1

<220>
<221>  misc_feature
<222>  (340)..(476)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (477)..(482)
<223>  Small terminator

<400>  72
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga agcggtgaaa ttctgtgggg ttttagagct aggccaacat      360

gaggatcacc catgtctgca gggcctagca agttaaaata aggctagtcc gttatcaact      420

tggccaacat gaggatcacc catgtctgca gggccaagtg gcaccgagtc ggtgcttttt      480

ttctagaggc                                                             490


<210>  73
<211>  490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (320)..(339)
<223>  Guide2

<220>
<221>  misc_feature
<222>  (340)..(476)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (477)..(482)
<223>  Small terminator

<400>  73
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccgc actcaaacag caacgcgggg ttttagagct aggccaacat      360

gaggatcacc catgtctgca gggcctagca agttaaaata aggctagtcc gttatcaact      420

tggccaacat gaggatcacc catgtctgca gggccaagtg gcaccgagtc ggtgcttttt      480

ttctagaggc                                                             490


<210>  74
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (319)..(338)
<223>  Guide3

<220>
<221>  misc_feature
<222>  (339)..(475)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (476)..(481)
<223>  Small terminator

<400>  74
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccct tcacctcact gagcgggggt tttagagcta ggccaacatg      360

aggatcaccc atgtctgcag ggcctagcaa gttaaaataa ggctagtccg ttatcaactt      420

ggccaacatg aggatcaccc atgtctgcag ggccaagtgg caccgagtcg gtgctttttt      480

tctagaggc                                                              489


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
aagcggtgaa attctgtggg                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
cactcaaaca gcaacgcggg                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
cttcacctca ctgagcgggg                                                   20


<210>  78
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
aagcggugaa auucuguggg guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  79
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
cacucaaaca gcaacgcggg guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  80
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
cuucaccuca cugagcgggg guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  81
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
aagcggugaa auucuguggg                                                   20


<210>  82
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
cacucaaaca gcaacgcggg                                                   20


<210>  83
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
cuucaccuca cugagcgggg                                                   20


<210>  84
<211>  1415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga       60

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      120

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      180

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      240

gaagcggtga aattctgtgg ggttttagag ctaggccaac atgaggatca cccatgtctg      300

cagggcctag caagttaaaa taaggctagt ccgttatcaa cttggccaac atgaggatca      360

cccatgtctg cagggccaag tggcaccgag tcggtgcttt ttttgtttta gagctagaaa      420

tagcaagtta aaataaggct agtccgtttt gagctccata agactcggcc ttagaacaag      480

ctttttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt      540

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa      600

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt      660

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac      720

accgcactca aacagcaacg cggggtttta gagctaggcc aacatgagga tcacccatgt      780

ctgcagggcc tagcaagtta aaataaggct agtccgttat caacttggcc aacatgagga      840

tcacccatgt ctgcagggcc aagtggcacc gagtcggtgc tttttttgtt ttagagctag      900

aaatagcaag ttaaaataag gctagtccgt tttatgcatg tggctcccat ttatacctgg      960

ccggctttcc catgattcct tcatatttgc atatacgata caaggctgtt agagagataa     1020

ttggaattaa tttgactgta aacacaaaga tattagtaca aaatacgtga cgtagaaagt     1080

aataatttct tgggtagttt gcagttttaa aattatgttt taaaatggac tatcatatgc     1140

ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg aaaggacgaa     1200

acaccgcttc acctcactga gcgggggttt tagagctagg ccaacatgag gatcacccat     1260

gtctgcaggg cctagcaagt taaaataagg ctagtccgtt atcaacttgg ccaacatgag     1320

gatcacccat gtctgcaggg ccaagtggca ccgagtcggt gctttttttg ttttagagct     1380

agaaatagca agttaaaata aggctagtcc gtttt                                1415


<210>  85
<211>  1490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (28)..(267)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (268)..(287)
<223>  Guide1

<220>
<221>  misc_feature
<222>  (288)..(424)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (425)..(476)
<223>  Extended terminator

<220>
<221>  misc_feature
<222>  (510)..(749)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (751)..(770)
<223>  Guide2

<220>
<221>  misc_feature
<222>  (771)..(907)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (908)..(959)
<223>  Extended terminator

<220>
<221>  misc_feature
<222>  (992)..(1231)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (1233)..(1252)
<223>  Guide3

<220>
<221>  misc_feature
<222>  (1253)..(1389)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (1390)..(1441)
<223>  Extended terminator

<400>  85
gctagccata agactcggcc ttagaacttt cccatgattc cttcatattt gcatatacga       60

tacaaggctg ttagagagat aattggaatt aatttgactg taaacacaaa gatattagta      120

caaaatacgt gacgtagaaa gtaataattt cttgggtagt ttgcagtttt aaaattatgt      180

tttaaaatgg actatcatat gcttaccgta acttgaaagt atttcgattt cttggcttta      240

tatatcttgt ggaaaggacg aaacaccgaa gagtcatggg tcacagggtt ttagagctag      300

gccaacatga ggatcaccca tgtctgcagg gcctagcaag ttaaaataag gctagtccgt      360

tatcaacttg gccaacatga ggatcaccca tgtctgcagg gccaagtggc accgagtcgg      420

tgcttttttt gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttttgagc      480

tccataagac tcggccttag aacaagcttt ttcccatgat tccttcatat ttgcatatac      540

gatacaaggc tgttagagag ataattggaa ttaatttgac tgtaaacaca aagatattag      600

tacaaaatac gtgacgtaga aagtaataat ttcttgggta gtttgcagtt ttaaaattat      660

gttttaaaat ggactatcat atgcttaccg taacttgaaa gtatttcgat ttcttggctt      720

tatatatctt gtggaaagga cgaaacaccg caggcggggt gccaactcag gttttagagc      780

taggccaaca tgaggatcac ccatgtctgc agggcctagc aagttaaaat aaggctagtc      840

cgttatcaac ttggccaaca tgaggatcac ccatgtctgc agggccaagt ggcaccgagt      900

cggtgctttt tttgttttag agctagaaat agcaagttaa aataaggcta gtccgtttta      960

tgcatgtggc tcccatttat acctggccgg ctttcccatg attccttcat atttgcatat     1020

acgatacaag gctgttagag agataattgg aattaatttg actgtaaaca caaagatatt     1080

agtacaaaat acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt     1140

atgttttaaa atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc     1200

tttatatatc ttgtggaaag gacgaaacac cgaatattaa ctaacttctc ctgttttaga     1260

gctaggccaa catgaggatc acccatgtct gcagggccta gcaagttaaa ataaggctag     1320

tccgttatca acttggccaa catgaggatc acccatgtct gcagggccaa gtggcaccga     1380

gtcggtgctt tttttgtttt agagctagaa atagcaagtt aaaataaggc tagtccgttt     1440

tggtcaccca gtgaggaagc taggacagac ctaggacggt tgcctgcagg                1490


<210>  86
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (319)..(338)
<223>  Guide1

<220>
<221>  misc_feature
<222>  (339)..(475)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (476)..(481)
<223>  Small terminator

<400>  86
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga agagtcatgg gtcacagggt tttagagcta ggccaacatg      360

aggatcaccc atgtctgcag ggcctagcaa gttaaaataa ggctagtccg ttatcaactt      420

ggccaacatg aggatcaccc atgtctgcag ggccaagtgg caccgagtcg gtgctttttt      480

tctagaggc                                                              489


<210>  87
<211>  490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (320)..(339)
<223>  Guide2

<220>
<221>  misc_feature
<222>  (340)..(476)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (477)..(482)
<223>  Small terminator

<400>  87
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccgc aggcggggtg ccaactcagg ttttagagct aggccaacat      360

gaggatcacc catgtctgca gggcctagca agttaaaata aggctagtcc gttatcaact      420

tggccaacat gaggatcacc catgtctgca gggccaagtg gcaccgagtc ggtgcttttt      480

ttctagaggc                                                             490


<210>  88
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (319)..(338)
<223>  Guide3

<220>
<221>  misc_feature
<222>  (339)..(475)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (476)..(481)
<223>  Small terminator

<400>  88
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccaa tattaactaa cttctcctgt tttagagcta ggccaacatg      360

aggatcaccc atgtctgcag ggcctagcaa gttaaaataa ggctagtccg ttatcaactt      420

ggccaacatg aggatcaccc atgtctgcag ggccaagtgg caccgagtcg gtgctttttt      480

tctagaggc                                                              489


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89
gaagagtcat gggtcacagg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
caggcggggt gccaactcag                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
aatattaact aacttctcct                                                   20


<210>  92
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
gaagagucau gggucacagg guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  93
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93
caggcggggu gccaacucag guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  94
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94
aauauuaacu aacuucuccu guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  95
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95
gaagagucau gggucacagg                                                   20


<210>  96
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96
caggcggggu gccaacucag                                                   20


<210>  97
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97
aauauuaacu aacuucuccu                                                   20


<210>  98
<211>  1414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98
tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga       60

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      120

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      180

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      240

gaagagtcat gggtcacagg gttttagagc taggccaaca tgaggatcac ccatgtctgc      300

agggcctagc aagttaaaat aaggctagtc cgttatcaac ttggccaaca tgaggatcac      360

ccatgtctgc agggccaagt ggcaccgagt cggtgctttt tttgttttag agctagaaat      420

agcaagttaa aataaggcta gtccgttttg agctccataa gactcggcct tagaacaagc      480

tttttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg      540

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat      600

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta      660

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca      720

ccgcaggcgg ggtgccaact caggttttag agctaggcca acatgaggat cacccatgtc      780

tgcagggcct agcaagttaa aataaggcta gtccgttatc aacttggcca acatgaggat      840

cacccatgtc tgcagggcca agtggcaccg agtcggtgct ttttttgttt tagagctaga      900

aatagcaagt taaaataagg ctagtccgtt ttatgcatgt ggctcccatt tatacctggc      960

cggctttccc atgattcctt catatttgca tatacgatac aaggctgtta gagagataat     1020

tggaattaat ttgactgtaa acacaaagat attagtacaa aatacgtgac gtagaaagta     1080

ataatttctt gggtagtttg cagttttaaa attatgtttt aaaatggact atcatatgct     1140

taccgtaact tgaaagtatt tcgatttctt ggctttatat atcttgtgga aaggacgaaa     1200

caccgaatat taactaactt ctcctgtttt agagctaggc caacatgagg atcacccatg     1260

tctgcagggc ctagcaagtt aaaataaggc tagtccgtta tcaacttggc caacatgagg     1320

atcacccatg tctgcagggc caagtggcac cgagtcggtg ctttttttgt tttagagcta     1380

gaaatagcaa gttaaaataa ggctagtccg tttt                                 1414


