                         SEQUENCE LISTING

<110>  CHO Pharma USA
 
<120>  Chimeric Antigen Receptors that Bind to SSEA4 and Uses Thereof

<130>  218407-0014

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  3972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1354)..(3972)

<400>  1
gagtaattca tacaaaagga ctcgcccctg ccttggggaa tcccagggac cgtcgttaaa       60

ctcccactaa cgtagaaccc agagatcgct gcgttcccgc cccctcaccc gcccgctctc      120

gtcatcactg aggtggagaa gagcatgcgt gaggctccgg tgcccgtcag tgggcagagc      180

gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga accggtgcct      240

agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc      300

ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca      360

acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct      420

ttacgggtta tggcccttgc gtgccttgaa ttacttccac gcccctggct gcagtacgtg      480

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      540

ggagcccctt cgcctcgtgc ttgagttgag gcctggcttg ggcgctgggg ccgccgcgtg      600

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      660

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      720

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      780

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg      840

gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc      900

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg      960

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1020

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1080

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1140

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1200

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1260

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1320

tttcaggtgt cgtgattcga attcgccgcc acc atg gcc tta cca gtg acc gcc      1374
                                     Met Ala Leu Pro Val Thr Ala          
                                     1               5                    

ttg ctc ctg ccg ctg gcc ttg ctg ctc cac gcc gcc agg ccg cag ctg       1422
Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Leu           
        10                  15                  20                        

caa gag tct ggc cct gga ctg gtc aag cct agc gag aca ctg agc ctg       1470
Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu           
    25                  30                  35                            

acc tgt acc gtg tcc ggc ttt agc ctg aca agc tac ggc gtg gac tgg       1518
Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val Asp Trp           
40                  45                  50                  55            

gtc cga cag cct cct gga aaa ggc ctg gaa tgg atc ggc gtt atc tgg       1566
Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp           
                60                  65                  70                

ggc gga ggc agc acc aac tac aac agc gcc ctg atg agc cgg ctg acc       1614
Gly Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser Arg Leu Thr           
            75                  80                  85                    

atc agc aag gac aac agc aag agc cag gtg tcc ctg aag ctg agc agc       1662
Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys Leu Ser Ser           
        90                  95                  100                       

gtg aca gcc gct gat acc gcc gtg tac tac tgt gcc aag cac gag gtg       1710
Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Glu Val           
    105                 110                 115                           

ctg aga ggc tac gcc ctg gat tat tgg ggc cag ggc aca ctg gtc aca       1758
Leu Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr           
120                 125                 130                 135           

gtg tct agc gga ggc gga gga agt ggt ggc gga gga tca ggc ggt ggt       1806
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
                140                 145                 150               

gga tct ctg aca cag tct ccc gct aca ctg tct ctg agc cct ggc gaa       1854
Gly Ser Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu           
            155                 160                 165                   

aga gcc aca ctg agc tgt tct gcc tct cct agc gtg tcc tac atg cac       1902
Arg Ala Thr Leu Ser Cys Ser Ala Ser Pro Ser Val Ser Tyr Met His           
        170                 175                 180                       

tgg tat cag cag aag ccc gga cag gcc cct aga ctg ctg atc tac gac       1950
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp           
    185                 190                 195                           

acc tac aag ctg gcc tct ggc atc ccc gcc aga ttt tct ggc tct ggc       1998
Thr Tyr Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly           
200                 205                 210                 215           

agc ggc acc gat ttc acc ctg acc ata agc agc ctg gaa cct gag gac       2046
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp           
                220                 225                 230               

ttc gct gtc tac tac tgc ttc caa ggc agc ggc ttc cct ctg aca ttt       2094
Phe Ala Val Tyr Tyr Cys Phe Gln Gly Ser Gly Phe Pro Leu Thr Phe           
            235                 240                 245                   

gga cag ggc acc aag gtg gaa atc aag acc act acc cca gca ccg agg       2142
Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg           
        250                 255                 260                       

cca ccc acc ccg gct cct acc atc gcc tcc cag cct ctg tcc ctg cgt       2190
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg           
    265                 270                 275                           

ccg gag gca tgt aga ccc gca gct ggt ggg gcc gtg cat acc cgg ggt       2238
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly           
280                 285                 290                 295           

ctt gac ttc gcc tgc gat atc tac att tgg gcc cct ctg gct ggt act       2286
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr           
                300                 305                 310               

tgc ggg gtc ctg ctg ctt tca ctc gtg atc act ctt tac tgt atc tac       2334
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Ile Tyr           
            315                 320                 325                   

att tgg gcc cct ctg gct ggt act tgc ggg gtc ctg ctg ctt tca ctc       2382
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu           
        330                 335                 340                       

gtg atc act ctt tac tgt aag cgc ggt cgg aag aag ctg ctg tac atc       2430
Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile           
    345                 350                 355                           

ttt aag caa ccc ttc atg agg cct gtg cag act act caa gag gag gac       2478
Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp           
360                 365                 370                 375           

ggc tgt tca tgc cgg ttc cca gag gag gag gaa ggc ggc tgc gaa ctg       2526
Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu           
                380                 385                 390               

cgc gtg aaa ttc agc cgc agc gca gat gct cca gcc tac aag cag ggg       2574
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly           
            395                 400                 405                   

cag aac cag ctc tac aac gaa ctc aat ctt ggt cgg aga gag gag tac       2622
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr           
        410                 415                 420                       

gac gtg ctg gac aag cgg aga gga cgg gac cca gaa atg ggc ggg aag       2670
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys           
    425                 430                 435                           

ccg cgc aga aag aat ccc caa gag ggc ctg tac aac gag ctc caa aag       2718
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys           
440                 445                 450                 455           

gat aag atg gca gaa gcc tat agc gag att ggt atg aaa ggg gaa cgc       2766
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg           
                460                 465                 470               

aga aga ggc aaa ggc cac gac gga ctg tac cag gga ctc agc acc gcc       2814
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala           
            475                 480                 485                   

acc aag gac acc tat gac gct ctt cac atg cag gcc ctg ccg cct cgg       2862
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg           
        490                 495                 500                       

gag ggc aga ggc agc ctg ctg aca tgt ggc gac gtg gaa gag aac cct       2910
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro           
    505                 510                 515                           

ggc ccc atg tgg ctg cag agc ctg ctg ctc ttg ggc act gtg gcc tgc       2958
Gly Pro Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys           
520                 525                 530                 535           

agc atc tct cgc aaa gtg tgt aac gga ata ggt att ggt gaa ttt aaa       3006
Ser Ile Ser Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys           
                540                 545                 550               

gac tca ctc tcc ata aat gct acg aat att aaa cac ttc aaa aac tgc       3054
Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys           
            555                 560                 565                   

acc tcc atc agt ggc gat ctc cac atc ctg ccg gtg gca ttt agg ggt       3102
Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly           
        570                 575                 580                       

gac tcc ttc aca cat act cct cct ctg gat cca cag gaa ctg gat att       3150
Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile           
    585                 590                 595                           

ctg aaa acc gta aag gaa atc aca ggg ttt ttg ctg att cag gct tgg       3198
Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp           
600                 605                 610                 615           

cct gaa aac agg acg gac ctc cat gcc ttt gag aac cta gaa atc ata       3246
Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile           
                620                 625                 630               

cgc ggc agg acc aag caa cat ggt cag ttt tct ctt gca gtc gtc agc       3294
Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser           
            635                 640                 645                   

ctg aac ata aca tcc ttg gga tta cgc tcc ctc aag gag ata agt gat       3342
Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp           
        650                 655                 660                       

gga gat gtg ata att tca gga aac aaa aat ttg tgc tat gca aat aca       3390
Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr           
    665                 670                 675                           

ata aac tgg aaa aaa ctg ttt ggg acc tcc ggt cag aaa acc aaa att       3438
Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile           
680                 685                 690                 695           

ata agc aac aga ggt gaa aac agc tgc aag gcc aca ggc cag gtc tgc       3486
Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys           
                700                 705                 710               

cat gcc ttg tgc tcc ccc gag ggc tgc tgg ggc ccg gag ccc agg gac       3534
His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp           
            715                 720                 725                   

tgc gtc tct tgc cgg aat gtc agc cga ggc agg gaa tgc gtg gac aag       3582
Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys           
        730                 735                 740                       

tgc aac ctt ctg gag ggt gag cca agg gag ttt gtg gag aac tct gag       3630
Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu           
    745                 750                 755                           

tgc ata cag tgc cac cca gag tgc ctg cct cag gcc atg aac atc acc       3678
Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr           
760                 765                 770                 775           

tgc aca gga cgg gga cca gac aac tgt atc cag tgt gcc cac tac att       3726
Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile           
                780                 785                 790               

gac ggc ccc cac tgc gtc aag acc tgc ccg gca gga gtc atg gga gaa       3774
Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu           
            795                 800                 805                   

aac aac acc ctg gtc tgg aag tac gca gac gcc ggc cat gtg tgc cac       3822
Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His           
        810                 815                 820                       

ctg tgc cat cca aac tgc acc tac gga tgc act ggg cca ggt ctt gaa       3870
Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu           
    825                 830                 835                           

ggc tgt cca acg aat ggg cct aag atc ccg tcc atc gcc act ggg atg       3918
Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met           
840                 845                 850                 855           

gtg ggg gcc ctc ctc ttg ctg ctg gtg gtg gcc ctg ggg atc ggc ctc       3966
Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu           
                860                 865                 870               

ttc atg                                                               3972
Phe Met                                                                   
                                                                          


<210>  2
<211>  873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Trp Gly Gly Gly Ser Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys His Glu Val Leu Arg Gly Tyr Ala Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Thr Gln Ser Pro Ala Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Pro Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            180                 185                 190         


Pro Arg Leu Leu Ile Tyr Asp Thr Tyr Lys Leu Ala Ser Gly Ile Pro 
        195                 200                 205             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
225                 230                 235                 240 


Ser Gly Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250                 255     


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
            260                 265                 270         


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
        275                 280                 285             


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
    290                 295                 300                 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
305                 310                 315                 320 


Ile Thr Leu Tyr Cys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
            340                 345                 350         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        355                 360                 365             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    370                 375                 380                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            500                 505                 510         


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Trp Leu Gln Ser Leu Leu 
        515                 520                 525             


Leu Leu Gly Thr Val Ala Cys Ser Ile Ser Arg Lys Val Cys Asn Gly 
    530                 535                 540                 


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
545                 550                 555                 560 


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
                565                 570                 575     


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
            580                 585                 590         


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
        595                 600                 605             


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
    610                 615                 620                 


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
625                 630                 635                 640 


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
                645                 650                 655     


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
            660                 665                 670         


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
        675                 680                 685             


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
    690                 695                 700                 


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
705                 710                 715                 720 


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
                725                 730                 735     


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
            740                 745                 750         


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
        755                 760                 765             


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
    770                 775                 780                 


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
785                 790                 795                 800 


Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala 
                805                 810                 815     


Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly 
            820                 825                 830         


Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile 
        835                 840                 845             


Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val 
    850                 855                 860                 


Val Ala Leu Gly Ile Gly Leu Phe Met 
865                 870             


<210>  3
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single chain Fv

<400>  3

Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu 
1               5                   10                  15      


Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val 
            20                  25                  30          


Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val 
        35                  40                  45              


Ile Trp Gly Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser Arg 
    50                  55                  60                  


Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu Lys Leu 
65                  70                  75                  80  


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His 
                85                  90                  95      


Glu Val Leu Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
    130                 135                 140                 


Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Pro Ser Val Ser Tyr 
145                 150                 155                 160 


Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                165                 170                 175     


Tyr Asp Thr Tyr Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
        195                 200                 205             


Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Ser Gly Phe Pro Leu 
    210                 215                 220                 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235 


<210>  4
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Trp Gly Gly Gly Ser Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Lys His Glu Val Leu Arg Gly Tyr Ala Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Thr Gln Ser Pro Ala Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Pro Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            180                 185                 190         


Pro Arg Leu Leu Ile Tyr Asp Thr Tyr Lys Leu Ala Ser Gly Ile Pro 
        195                 200                 205             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
225                 230                 235                 240 


Ser Gly Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250                 255     


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
            260                 265                 270         


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
        275                 280                 285             


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Lys Arg Gly 
    290                 295                 300                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
305                 310                 315                 320 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                325                 330                 335     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            340                 345                 350         


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        355                 360                 365             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    370                 375                 380                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                405                 410                 415     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             


Met Gln Ala Leu Pro Pro Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys 
    450                 455                 460                 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Trp Leu Gln Ser Leu Leu 
465                 470                 475                 480 


Leu Leu Gly Thr Val Ala Cys Ser Ile Ser 
                485                 490 


<210>  5
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ploypeptide

<400>  5

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
            20                  25                  30          


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
        35                  40                  45              


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
    50                  55                  60                  


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
65                  70                  75                  80  


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
                85                  90                  95      


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
            100                 105                 110         


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
        115                 120                 125             


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
    130                 135                 140                 


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
145                 150                 155                 160 


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
                165                 170                 175     


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
            180                 185                 190         


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
        195                 200                 205             


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
    210                 215                 220                 


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
225                 230                 235                 240 


Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr 
                245                 250                 255     


Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly 
            260                 265                 270         


Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn 
        275                 280                 285             


Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys 
    290                 295                 300                 


His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys 
305                 310                 315                 320 


Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly 
                325                 330                 335     


Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
            340                 345                 350         


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
tgacagccgc ctagcatttc                                                   20


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
gctcgatatc agcagttctt gaag                                              24


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic probe

<400>  8
cacgtggccc gagagctgca tc                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  9
gctgtcatct cttgtgggct gt                                                22


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  10
actcatggga gctgctggtt c                                                 21


<210>  11
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic probe

<400>  11
cctgtcatgc ccacacaaat ctctcc                                            26


