                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> METHODS AND COMPOSITIONS RELATING TO LUNG REPAIR

<130> 701039-090440WOPT

<140>
<141>

<150> 62/646,493
<151> 2018-03-22

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 6499
<212> DNA
<213> Homo sapiens

<400> 1
atcgaggtcc gcgggaggct cggagcgcgc caggcggaca ctcctctcgg ctcctccccg       60

gcagcggcgg cggctcggag cgggctccgg ggctcgggtg cagcggccag cgggcgcctg      120

gcggcgagga ttacccgggg aagtggttgt ctcctggctg gagccgcgag acgggcgctc      180

agggcgcggg gccggcggcg gcgaacgaga ggacggactc tggcggccgg gtcgttggcc      240

gcggggagcg cgggcaccgg gcgagcaggc cgcgtcgcgc tcaccatggt cagctactgg      300

gacaccgggg tcctgctgtg cgcgctgctc agctgtctgc ttctcacagg atctagttca      360

ggttcaaaat taaaagatcc tgaactgagt ttaaaaggca cccagcacat catgcaagca      420

ggccagacac tgcatctcca atgcaggggg gaagcagccc ataaatggtc tttgcctgaa      480

atggtgagta aggaaagcga aaggctgagc ataactaaat ctgcctgtgg aagaaatggc      540

aaacaattct gcagtacttt aaccttgaac acagctcaag caaaccacac tggcttctac      600

agctgcaaat atctagctgt acctacttca aagaagaagg aaacagaatc tgcaatctat      660

atatttatta gtgatacagg tagacctttc gtagagatgt acagtgaaat ccccgaaatt      720

atacacatga ctgaaggaag ggagctcgtc attccctgcc gggttacgtc acctaacatc      780

actgttactt taaaaaagtt tccacttgac actttgatcc ctgatggaaa acgcataatc      840

tgggacagta gaaagggctt catcatatca aatgcaacgt acaaagaaat agggcttctg      900

acctgtgaag caacagtcaa tgggcatttg tataagacaa actatctcac acatcgacaa      960

accaatacaa tcatagatgt ccaaataagc acaccacgcc cagtcaaatt acttagaggc     1020

catactcttg tcctcaattg tactgctacc actcccttga acacgagagt tcaaatgacc     1080

tggagttacc ctgatgaaaa aaataagaga gcttccgtaa ggcgacgaat tgaccaaagc     1140

aattcccatg ccaacatatt ctacagtgtt cttactattg acaaaatgca gaacaaagac     1200

aaaggacttt atacttgtcg tgtaaggagt ggaccatcat tcaaatctgt taacacctca     1260

gtgcatatat atgataaagc attcatcact gtgaaacatc gaaaacagca ggtgcttgaa     1320

accgtagctg gcaagcggtc ttaccggctc tctatgaaag tgaaggcatt tccctcgccg     1380

gaagttgtat ggttaaaaga tgggttacct gcgactgaga aatctgctcg ctatttgact     1440

cgtggctact cgttaattat caaggacgta actgaagagg atgcagggaa ttatacaatc     1500

ttgctgagca taaaacagtc aaatgtgttt aaaaacctca ctgccactct aattgtcaat     1560

gtgaaacccc agatttacga aaaggccgtg tcatcgtttc cagacccggc tctctaccca     1620

ctgggcagca gacaaatcct gacttgtacc gcatatggta tccctcaacc tacaatcaag     1680

tggttctggc acccctgtaa ccataatcat tccgaagcaa ggtgtgactt ttgttccaat     1740

aatgaagagt cctttatcct ggatgctgac agcaacatgg gaaacagaat tgagagcatc     1800

actcagcgca tggcaataat agaaggaaag aataagatgg ctagcacctt ggttgtggct     1860

gactctagaa tttctggaat ctacatttgc atagcttcca ataaagttgg gactgtggga     1920

agaaacataa gcttttatat cacagatgtg ccaaatgggt ttcatgttaa cttggaaaaa     1980

atgccgacgg aaggagagga cctgaaactg tcttgcacag ttaacaagtt cttatacaga     2040

gacgttactt ggattttact gcggacagtt aataacagaa caatgcacta cagtattagc     2100

aagcaaaaaa tggccatcac taaggagcac tccatcactc ttaatcttac catcatgaat     2160

gtttccctgc aagattcagg cacctatgcc tgcagagcca ggaatgtata cacaggggaa     2220

gaaatcctcc agaagaaaga aattacaatc agaggtgagc actgcaacaa aaaggctgtt     2280

ttctctcgga tctccaaatt taaaagcaca aggaatgatt gtaccacaca aagtaatgta     2340

aaacattaaa ggactcatta aaaagtaaca gttgtctcat atcatcttga tttattgtca     2400

ctgttgctaa ctttcaggct cggaggagat gctcctccca aaatgagttc ggagatgata     2460

gcagtaataa tgagaccccc gggccccagc tctgggcccc ccattcaggc cgagggggct     2520

gctccggggg gccgacttgg tgcacgtttg gatttggagg atccctgcac tgccttctct     2580

gtgtttgttg ctcttgctgt tttctcctgc ctgataaaca acaacttggg atgatccttt     2640

ccttccattt tgatgccaac ctctttttat ttttaagtgt tgaagctgca caaactgaat     2700

aatttaaaca aatgctggtt tctgccaaag atggacacga ataagttaat tttccagctc     2760

agaatgagta cagttgaatt tgagactctg tcggacttct gcctggtttt atttgggact     2820

atttcatctg ctcttgattt gtaaatagca cctggatagc aagttataat gcttatttat     2880

ttgaaaatgc tttttttttt tttacgttaa gcacatttat cttgaactgg agcttctaaa     2940

atgggcccca ggggtgcaag atgttggtgt aattcagaga tagtaaaggt ttatcgcagt     3000

gtgaattata agagtccatc caaatcaacg tcccctccct cctctcatgc gatccaggta     3060

attatgcagt tagtgccaca gtagactagc ctagcaaagg gtttgctcct tgctgtctct     3120

gactgcacca cacagctatt gatggcagct gaaagaaagt ggatcatgcc ttaattttaa     3180

atattcctgt cctctggtta ttattttaag gaacttcatc atgttaaaat gacagcattc     3240

aaaggtgtac cacaatcaat ttatcaagga aataaaggct attgtaacca gagatttaat     3300

gcattcttct aaatgtaaat ttaaaatttg ccctttaaaa aagtccactt tccccatatg     3360

caaatgttaa taggattttt atggggatta agaagcggca aaactacaga agcagaattc     3420

aaagtaattt aaaaaataca caccagtttt aaatcaagag aagttgtaat ctcttgtttt     3480

aagcttgcgt ttgagggaaa atgacttttt caccaattta atatgcattg ttctgttgtt     3540

tttatttatg attgatcatt atatgtgact tgcataaact atttaaaaaa aaaaactata     3600

atgaccaaaa tagccatggc tgagaaacac agtggctggg cagttcaata ggaggtgaca     3660

atatgacaac ttctcaagct tgggaactca ccagactgtt tcctccttta ggtaacagat     3720

tctgtcccac ggctaaactt gtctttcacg tgggaattgc ttttgtcaaa cgtgaaagag     3780

taaacaatag catttcccca gaatgccagt tttatggagc cccaaatgct ctgaaaacaa     3840

ttagtaacct ggaagttgtc agcccaaagg aaagaaaaat caattgtatc ttgaaatttt     3900

acctatggct ctttggcctg gcttctttgt tcattataag ttagtgtgtt ccttcaggaa     3960

acaatgcctt aataccatag aacatggggg ccttaatagt tgctaacatt aaaaaagcaa     4020

acagaatgat tgagggatcc ttatgaaaac aaaatggtga attggacatg cagaacctac     4080

catttccttc ccctgtttgc aatttttgtg gggaggggag gatgttagta tttacaaaag     4140

atgattttaa gaacttccaa gagatgagtt taagaattcc atagagtatt agttgttcac     4200

tgtgtaatta atccttccgg agagtctttt tttttttttt taaagaaact tttgggtggg     4260

ttttgttttt tattagttac cctaggggta tgttaccctg gggtatgaag ggaggtgaag     4320

ataacggagg ggggagaaaa aaaaaaggag aaaaaaggag cctaaaatgg ggaataattg     4380

aaatggaaca gggggtgtga ggctggttcc tcagtcccca ttccaaacgg aggatagaag     4440

ctgtgtattt atgtgacctg gcagatctct ggggccataa cactgaaaag tgaaagaacc     4500

tggtgggcag ctatctttgg ctactgataa ccagcagaaa tgtctgttaa ttctgatttt     4560

ctcaatttga agggatcagc tacactgtta aattttggaa agccactacc tacttccatc     4620

aagtaactta ggtttcgaaa tatgggttca acgcacctcc cttattcaaa atgtcaaaat     4680

agattattat aatgtataaa gtaagaattg acaaaatatg attcttgggt tgattggtca     4740

tttagaaact agccaaaagt gagactttta atgtagaaca tttttcagaa atgggtacaa     4800

agaaaaatgc atattactgt atatttcaga gtgtttatgt gaaccttgta tttaattgag     4860

agtcccatgt acgttctgca gcctttttgc tgcttctatc atctgaagtt tgtgtagtac     4920

aaataaggcc tttgggattc ttaatgacat ttatgttaaa atgttctctt ctctttaaac     4980

accgttttcc aatccacctg tcagggagtc caaatcgtgt ctgtgttgat gatgctatac     5040

tttgtagcta gaaaaacaat tttagtgttg tgggctctgt attcagactt cctttttaca     5100

agaccgatgg gcagtgatag attattttat catatttaat gcatgggaaa tagtgtgctg     5160

aggaagctat taaaagtata actcagtgaa ttgggtctga gttttaaatg agatatttca     5220

aaattggctt gccactgtaa aagcgactaa ataataatat gatactgttc tttatgatct     5280

tgtcatgttt cactgatatg tttggggtct tcactatgta aaaaatgtca aaattgtaat     5340

gagcaagcat gtacaagtag tcgtaaatca aaggttttaa acaggactgc attttcaatt     5400

aggaaaagct gtttggcaga tagcatccaa tgcaaaaaca gaaatatcgt aacgttctgc     5460

ttagtgggca agataagata ggaaagacat gctcaaagag gcaaaagaat cattgctatc     5520

attcattcta cactagtttg aagaagtttt tgtacatcag agcacttcct tcagcacact     5580

tttttgcctt cagatttcat tttttataaa atgagaagac taatgataaa ctgtagaaat     5640

caaaatttat tgagaaatct gtttctccta acagatagta accctgccat gatatactac     5700

ttcaacaatg ttataaaatt tatgtgataa tatacatttt aacctgggat ttctaaattg     5760

ctttaacaaa tgctaatcct gagagttgcc ctgcaggact caaaagggaa aggttttggg     5820

acgtggcaga accctgcagg gacatggaat taaggccatt gcaatgtatc atctttgtag     5880

cattgtcatc actcctaagc tgccttcaca gttttagtac actaagatga ggaaatcgaa     5940

aatgggcaga gaaagctcat actgtataat tgaagacagt gacagagaac gtgtcagtta     6000

tgccaaaact cttttgattt ctgttccagg atttccaaca agaggggaaa ggaatgactt     6060

gggagggtgg gaaagacatt aggagttgtt tttatttttt accttggaag ctttagctac     6120

caatccagta ccctcctaac tagaatgtat acacatcagc aggactgact gactacttca     6180

ttagagatat actgtactca ttgggggcct tgggggtact gctgttctta tgtgggattt     6240

taatgttgta atgtattgca tcttaatgta ttgaattcat tttgttgtac tatattggtt     6300

ggcattttat taaaataaat tgtattgtat catatttgta tgttttaaga gaaaataata     6360

taaaatacaa tatttgtact attatatagt gcaaaaacta caaatctgtg cctctgcctc     6420

ttgaattaat tctttggttg cttgcatttg ggaagggaat ggagaaagga aagaaccaat     6480

aaagctttca aagttcaag                                                  6499


<210> 2
<211> 687
<212> PRT
<213> Homo sapiens

<400> 2
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Gly Glu His Cys Asn Lys Lys Ala Val Phe Ser Arg Ile Ser Lys Phe 
            660                 665                 670         


Lys Ser Thr Arg Asn Asp Cys Thr Thr Gln Ser Asn Val Lys His 
        675                 680                 685         


<210> 3
<211> 733
<212> PRT
<213> Mus musculus

<400> 3
Ser Lys Leu Lys Val Pro Glu Leu Ser Leu Lys Gly Thr Gln His Val 
1               5                   10                  15      


Met Gln Ala Gly Gln Thr Leu Phe Leu Lys Cys Arg Gly Glu Ala Ala 
            20                  25                  30          


His Ser Trp Ser Leu Pro Thr Thr Val Ser Gln Glu Asp Lys Arg Leu 
        35                  40                  45              


Ser Ile Thr Pro Pro Ser Ala Cys Gly Arg Asp Asn Arg Gln Phe Cys 
    50                  55                  60                  


Ser Thr Leu Thr Leu Asp Thr Ala Gln Ala Asn His Thr Gly Leu Tyr 
65                  70                  75                  80  


Thr Cys Arg Tyr Leu Pro Thr Ser Thr Ser Lys Lys Lys Lys Ala Glu 
                85                  90                  95      


Ser Ser Ile Tyr Ile Phe Val Ser Asp Ala Gly Ser Pro Phe Ile Glu 
            100                 105                 110         


Met His Thr Asp Ile Pro Lys Leu Val His Met Thr Glu Gly Arg Gln 
        115                 120                 125             


Leu Ile Ile Pro Cys Arg Val Thr Ser Pro Asn Val Thr Val Thr Leu 
    130                 135                 140                 


Lys Lys Phe Pro Phe Asp Thr Leu Thr Pro Asp Gly Gln Arg Ile Thr 
145                 150                 155                 160 


Trp Asp Ser Arg Arg Gly Phe Ile Ile Ala Asn Ala Thr Tyr Lys Glu 
                165                 170                 175     


Ile Gly Leu Leu Asn Cys Glu Ala Thr Val Asn Gly His Leu Tyr Gln 
            180                 185                 190         


Thr Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Leu Asp Val Gln 
        195                 200                 205             


Ile Arg Pro Pro Ser Pro Val Arg Leu Leu His Gly Gln Thr Leu Val 
    210                 215                 220                 


Leu Asn Cys Thr Ala Thr Thr Glu Leu Asn Thr Arg Val Gln Met Ser 
225                 230                 235                 240 


Trp Asn Tyr Pro Gly Lys Ala Thr Lys Arg Ala Ser Ile Arg Gln Arg 
                245                 250                 255     


Ile Asp Arg Ser His Ser His Asn Asn Val Phe His Ser Val Leu Lys 
            260                 265                 270         


Ile Asn Asn Val Glu Ser Arg Asp Lys Gly Leu Tyr Thr Cys Arg Val 
        275                 280                 285             


Lys Ser Gly Ser Ser Phe Gln Ser Phe Asn Thr Ser Val His Val Tyr 
    290                 295                 300                 


Glu Lys Gly Phe Ile Ser Val Lys His Arg Lys Gln Pro Val Gln Glu 
305                 310                 315                 320 


Thr Thr Ala Gly Arg Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala 
                325                 330                 335     


Phe Pro Ser Pro Glu Ile Val Trp Leu Lys Asp Gly Ser Pro Ala Thr 
            340                 345                 350         


Leu Lys Ser Ala Arg Tyr Leu Val His Gly Tyr Ser Leu Ile Ile Lys 
        355                 360                 365             


Asp Val Thr Thr Glu Asp Ala Gly Asp Tyr Thr Ile Leu Leu Gly Ile 
    370                 375                 380                 


Lys Gln Ser Arg Leu Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn 
385                 390                 395                 400 


Val Lys Pro Gln Ile Tyr Glu Lys Ser Val Ser Ser Leu Pro Ser Pro 
                405                 410                 415     


Pro Leu Tyr Pro Leu Gly Ser Arg Gln Val Leu Thr Cys Thr Val Tyr 
            420                 425                 430         


Gly Ile Pro Arg Pro Thr Ile Thr Trp Leu Trp His Pro Cys His His 
        435                 440                 445             


Asn His Ser Lys Glu Arg Tyr Asp Phe Cys Thr Glu Asn Glu Glu Ser 
    450                 455                 460                 


Phe Ile Leu Asp Pro Ser Ser Asn Leu Gly Asn Arg Ile Glu Ser Ile 
465                 470                 475                 480 


Ser Gln Arg Met Thr Val Ile Glu Gly Thr Asn Lys Thr Val Ser Thr 
                485                 490                 495     


Leu Val Val Ala Asp Ser Gln Thr Pro Gly Ile Tyr Ser Cys Arg Ala 
            500                 505                 510         


Phe Asn Lys Ile Gly Thr Val Glu Arg Asn Ile Lys Phe Tyr Val Thr 
        515                 520                 525             


Asp Val Pro Asn Gly Phe His Val Ser Leu Glu Lys Met Pro Ala Glu 
    530                 535                 540                 


Gly Glu Asp Leu Lys Leu Ser Cys Val Val Asn Lys Phe Leu Tyr Arg 
545                 550                 555                 560 


Asp Ile Thr Trp Ile Leu Leu Arg Thr Val Asn Asn Arg Thr Met His 
                565                 570                 575     


His Ser Ile Ser Lys Gln Lys Met Ala Thr Thr Gln Asp Tyr Ser Ile 
            580                 585                 590         


Thr Leu Asn Leu Val Ile Lys Asn Val Ser Leu Glu Asp Ser Gly Thr 
        595                 600                 605             


Tyr Ala Cys Arg Ala Arg Asn Ile Tyr Thr Gly Glu Asp Ile Leu Arg 
    610                 615                 620                 


Lys Thr Glu Val Leu Val Arg Asp Ser Glu Ala Pro His Leu Leu Gln 
625                 630                 635                 640 


Asn Leu Ser Asp Tyr Glu Val Ser Ile Ser Gly Ser Thr Thr Leu Asp 
                645                 650                 655     


Cys Gln Ala Arg Gly Val Pro Ala Pro Gln Ile Thr Trp Phe Lys Asn 
            660                 665                 670         


Asn His Lys Ile Gln Gln Glu Pro Gly Ile Ile Leu Gly Pro Gly Asn 
        675                 680                 685             


Ser Thr Leu Phe Ile Glu Arg Val Thr Glu Glu Asp Glu Gly Val Tyr 
    690                 695                 700                 


Arg Cys Arg Ala Thr Asn Gln Lys Gly Ala Val Glu Ser Ala Ala Tyr 
705                 710                 715                 720 


Leu Thr Val Gln Gly Thr Ser Asp Lys Ser Asn Leu Glu 
                725                 730             


<210> 4
<211> 630
<212> PRT
<213> Homo sapiens

<400> 4
Ser Lys Leu Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile 
1               5                   10                  15      


Met Gln Ala Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala 
            20                  25                  30          


His Lys Trp Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu 
        35                  40                  45              


Ser Ile Thr Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser 
    50                  55                  60                  


Thr Leu Thr Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser 
65                  70                  75                  80  


Cys Lys Tyr Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser 
                85                  90                  95      


Ala Ile Tyr Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met 
            100                 105                 110         


Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu 
        115                 120                 125             


Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys 
    130                 135                 140                 


Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp 
145                 150                 155                 160 


Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile 
                165                 170                 175     


Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr 
            180                 185                 190         


Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Gln Ile 
        195                 200                 205             


Ser Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu 
    210                 215                 220                 


Asn Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp 
225                 230                 235                 240 


Ser Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile 
                245                 250                 255     


Asp Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile 
            260                 265                 270         


Asp Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg 
        275                 280                 285             


Ser Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp 
    290                 295                 300                 


Lys Ala Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr 
305                 310                 315                 320 


Val Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe 
                325                 330                 335     


Pro Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu 
            340                 345                 350         


Lys Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp 
        355                 360                 365             


Val Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys 
    370                 375                 380                 


Gln Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val 
385                 390                 395                 400 


Lys Pro Gln Ile Tyr Glu Lys Ala Val Ser Ser Phe Pro Asp Pro Ala 
                405                 410                 415     


Leu Tyr Pro Leu Gly Ser Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly 
            420                 425                 430         


Ile Pro Gln Pro Thr Ile Lys Trp Phe Trp His Pro Cys Asn His Asn 
        435                 440                 445             


His Ser Glu Ala Arg Cys Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe 
    450                 455                 460                 


Ile Leu Asp Ala Asp Ser Asn Met Gly Asn Arg Ile Glu Ser Ile Thr 
465                 470                 475                 480 


Gln Arg Met Ala Ile Ile Glu Gly Lys Asn Lys Met Ala Ser Thr Leu 
                485                 490                 495     


Val Val Ala Asp Ser Arg Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser 
            500                 505                 510         


Asn Lys Val Gly Thr Val Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp 
        515                 520                 525             


Val Pro Asn Gly Phe His Val Asn Leu Glu Lys Met Pro Thr Glu Gly 
    530                 535                 540                 


Glu Asp Leu Lys Leu Ser Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp 
545                 550                 555                 560 


Val Thr Trp Ile Leu Leu Arg Thr Val Asn Asn Arg Thr Met His Tyr 
                565                 570                 575     


Ser Ile Ser Lys Gln Lys Met Ala Ile Thr Lys Glu His Ser Ile Thr 
            580                 585                 590         


Leu Asn Leu Thr Ile Met Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr 
        595                 600                 605             


Ala Cys Arg Ala Arg Asn Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys 
    610                 615                 620                 


Lys Glu Ile Thr Ile Arg 
625                 630 


<210> 5
<211> 733
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Glu Leu Tyr Thr Ser Thr Ser Pro Ser Ser Ser Ser Ser Ser Pro 
705                 710                 715                 720 


Leu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                725                 730             


<210> 6
<211> 639
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Ser Lys Leu Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile 
1               5                   10                  15      


Met Gln Ala Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala 
            20                  25                  30          


His Lys Trp Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu 
        35                  40                  45              


Ser Ile Thr Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser 
    50                  55                  60                  


Thr Leu Thr Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser 
65                  70                  75                  80  


Cys Lys Tyr Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser 
                85                  90                  95      


Ala Ile Tyr Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met 
            100                 105                 110         


Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu 
        115                 120                 125             


Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys 
    130                 135                 140                 


Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp 
145                 150                 155                 160 


Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile 
                165                 170                 175     


Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr 
            180                 185                 190         


Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Gln Ile 
        195                 200                 205             


Ser Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu 
    210                 215                 220                 


Asn Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp 
225                 230                 235                 240 


Ser Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile 
                245                 250                 255     


Asp Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile 
            260                 265                 270         


Asp Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg 
        275                 280                 285             


Ser Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp 
    290                 295                 300                 


Lys Ala Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr 
305                 310                 315                 320 


Val Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe 
                325                 330                 335     


Pro Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu 
            340                 345                 350         


Lys Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp 
        355                 360                 365             


Val Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys 
    370                 375                 380                 


Gln Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val 
385                 390                 395                 400 


Lys Pro Gln Ile Tyr Glu Lys Ala Val Ser Ser Phe Pro Asp Pro Ala 
                405                 410                 415     


Leu Tyr Pro Leu Gly Ser Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly 
            420                 425                 430         


Ile Pro Gln Pro Thr Ile Lys Trp Phe Trp His Pro Cys Asn His Asn 
        435                 440                 445             


His Ser Glu Ala Arg Cys Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe 
    450                 455                 460                 


Ile Leu Asp Ala Asp Ser Asn Met Gly Asn Arg Ile Glu Ser Ile Thr 
465                 470                 475                 480 


Gln Arg Met Ala Ile Ile Glu Gly Lys Asn Lys Met Ala Ser Thr Leu 
                485                 490                 495     


Val Val Ala Asp Ser Arg Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser 
            500                 505                 510         


Asn Lys Val Gly Thr Val Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp 
        515                 520                 525             


Val Pro Asn Gly Phe His Val Asn Leu Glu Lys Met Pro Thr Glu Gly 
    530                 535                 540                 


Glu Asp Leu Lys Leu Ser Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp 
545                 550                 555                 560 


Val Thr Trp Ile Leu Leu Arg Thr Val Asn Asn Arg Thr Met His Tyr 
                565                 570                 575     


Ser Ile Ser Lys Gln Lys Met Ala Ile Thr Lys Glu His Ser Ile Thr 
            580                 585                 590         


Leu Asn Leu Thr Ile Met Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr 
        595                 600                 605             


Ala Cys Arg Ala Arg Asn Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys 
    610                 615                 620                 


Lys Glu Ile Thr Ile Arg Asp Gln Glu Ala Ile Gln Gln Glu Pro 
625                 630                 635                 


<210> 7
<211> 667
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Ser Lys Leu Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile 
1               5                   10                  15      


Met Gln Ala Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala 
            20                  25                  30          


His Lys Trp Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu 
        35                  40                  45              


Ser Ile Thr Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser 
    50                  55                  60                  


Thr Leu Thr Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser 
65                  70                  75                  80  


Cys Lys Tyr Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser 
                85                  90                  95      


Ala Ile Tyr Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met 
            100                 105                 110         


Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu 
        115                 120                 125             


Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys 
    130                 135                 140                 


Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp 
145                 150                 155                 160 


Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile 
                165                 170                 175     


Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr 
            180                 185                 190         


Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Gln Ile 
        195                 200                 205             


Ser Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu 
    210                 215                 220                 


Asn Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp 
225                 230                 235                 240 


Ser Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile 
                245                 250                 255     


Asp Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile 
            260                 265                 270         


Asp Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg 
        275                 280                 285             


Ser Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp 
    290                 295                 300                 


Lys Ala Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr 
305                 310                 315                 320 


Val Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe 
                325                 330                 335     


Pro Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu 
            340                 345                 350         


Lys Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp 
        355                 360                 365             


Val Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys 
    370                 375                 380                 


Gln Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val 
385                 390                 395                 400 


Lys Pro Gln Ile Tyr Glu Lys Ala Val Ser Ser Phe Pro Asp Pro Ala 
                405                 410                 415     


Leu Tyr Pro Leu Gly Ser Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly 
            420                 425                 430         


Ile Pro Gln Pro Thr Ile Lys Trp Phe Trp His Pro Cys Asn His Asn 
        435                 440                 445             


His Ser Glu Ala Arg Cys Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe 
    450                 455                 460                 


Ile Leu Asp Ala Asp Ser Asn Met Gly Asn Arg Ile Glu Ser Ile Thr 
465                 470                 475                 480 


Gln Arg Met Ala Ile Ile Glu Gly Lys Asn Lys Met Ala Ser Thr Leu 
                485                 490                 495     


Val Val Ala Asp Ser Arg Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser 
            500                 505                 510         


Asn Lys Val Gly Thr Val Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp 
        515                 520                 525             


Val Pro Asn Gly Phe His Val Asn Leu Glu Lys Met Pro Thr Glu Gly 
    530                 535                 540                 


Glu Asp Leu Lys Leu Ser Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp 
545                 550                 555                 560 


Val Thr Trp Ile Leu Leu Arg Thr Val Asn Asn Arg Thr Met His Tyr 
                565                 570                 575     


Ser Ile Ser Lys Gln Lys Met Ala Ile Thr Lys Glu His Ser Ile Thr 
            580                 585                 590         


Leu Asn Leu Thr Ile Met Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr 
        595                 600                 605             


Ala Cys Arg Ala Arg Asn Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys 
    610                 615                 620                 


Lys Glu Ile Thr Ile Arg Asp Gln Glu Ala Ile Gln Gln Glu Pro Glu 
625                 630                 635                 640 


Leu Tyr Thr Ser Thr Ser Pro Ser Ser Ser Ser Ser Ser Pro Leu Ser 
                645                 650                 655     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
            660                 665         


<210> 8
<211> 541
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Leu Pro Pro Ala Asn Ser Ser Phe Met Leu Pro 
        515                 520                 525             


Pro Thr Ser Phe Ser Ser Asn Tyr Phe His Phe Leu Pro 
    530                 535                 540     


<210> 9
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Ser Lys Leu Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile 
1               5                   10                  15      


Met Gln Ala Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala 
            20                  25                  30          


His Lys Trp Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu 
        35                  40                  45              


Ser Ile Thr Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser 
    50                  55                  60                  


Thr Leu Thr Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser 
65                  70                  75                  80  


Cys Lys Tyr Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser 
                85                  90                  95      


Ala Ile Tyr Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met 
            100                 105                 110         


Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu 
        115                 120                 125             


Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys 
    130                 135                 140                 


Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp 
145                 150                 155                 160 


Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile 
                165                 170                 175     


Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr 
            180                 185                 190         


Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Gln Ile 
        195                 200                 205             


Ser Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu 
    210                 215                 220                 


Asn Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp 
225                 230                 235                 240 


Ser Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile 
                245                 250                 255     


Asp Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile 
            260                 265                 270         


Asp Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg 
        275                 280                 285             


Ser Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp 
    290                 295                 300                 


Lys Ala Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr 
305                 310                 315                 320 


Val Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe 
                325                 330                 335     


Pro Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu 
            340                 345                 350         


Lys Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp 
        355                 360                 365             


Val Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys 
    370                 375                 380                 


Gln Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val 
385                 390                 395                 400 


Lys Pro Gln Ile Tyr Glu Lys Ala Val Ser Ser Phe Pro Asp Pro Ala 
                405                 410                 415     


Leu Tyr Pro Leu Gly Ser Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly 
            420                 425                 430         


Ile Pro Gln Pro Thr Ile Lys Trp Phe Trp His Pro Cys Asn His Asn 
        435                 440                 445             


His Ser Glu Ala Arg Cys Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe 
    450                 455                 460                 


Ile Leu Asp Ala Asp Ser Asn Met Gly Asn Arg Ile Glu Ser Ile Thr 
465                 470                 475                 480 


Gln Arg Met Ala Ile Ile Glu Gly Lys Asn Lys 
                485                 490     


<210> 10
<211> 515
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Ser Lys Leu Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile 
1               5                   10                  15      


Met Gln Ala Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala 
            20                  25                  30          


His Lys Trp Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu 
        35                  40                  45              


Ser Ile Thr Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser 
    50                  55                  60                  


Thr Leu Thr Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser 
65                  70                  75                  80  


Cys Lys Tyr Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser 
                85                  90                  95      


Ala Ile Tyr Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met 
            100                 105                 110         


Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu 
        115                 120                 125             


Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys 
    130                 135                 140                 


Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp 
145                 150                 155                 160 


Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile 
                165                 170                 175     


Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr 
            180                 185                 190         


Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Gln Ile 
        195                 200                 205             


Ser Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu 
    210                 215                 220                 


Asn Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp 
225                 230                 235                 240 


Ser Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile 
                245                 250                 255     


Asp Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile 
            260                 265                 270         


Asp Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg 
        275                 280                 285             


Ser Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp 
    290                 295                 300                 


Lys Ala Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr 
305                 310                 315                 320 


Val Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe 
                325                 330                 335     


Pro Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu 
            340                 345                 350         


Lys Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp 
        355                 360                 365             


Val Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys 
    370                 375                 380                 


Gln Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val 
385                 390                 395                 400 


Lys Pro Gln Ile Tyr Glu Lys Ala Val Ser Ser Phe Pro Asp Pro Ala 
                405                 410                 415     


Leu Tyr Pro Leu Gly Ser Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly 
            420                 425                 430         


Ile Pro Gln Pro Thr Ile Lys Trp Phe Trp His Pro Cys Asn His Asn 
        435                 440                 445             


His Ser Glu Ala Arg Cys Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe 
    450                 455                 460                 


Ile Leu Asp Ala Asp Ser Asn Met Gly Asn Arg Ile Glu Ser Ile Thr 
465                 470                 475                 480 


Gln Arg Met Ala Ile Ile Glu Gly Lys Asn Lys Leu Pro Pro Ala Asn 
                485                 490                 495     


Ser Ser Phe Met Leu Pro Pro Thr Ser Phe Ser Ser Asn Tyr Phe His 
            500                 505                 510         


Phe Leu Pro 
        515 


<210> 11
<211> 1338
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile  Ser Tyr Ser Phe Gln  Val Ala Arg 
        995                 1000                 1005             


Gly Met  Glu Phe Leu Ser Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1010                 1015                 1020             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Asn Asn Val  Val Lys Ile 
    1025                 1030                 1035             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asn  Pro Asp Tyr 
    1040                 1045                 1050             


Val Arg  Lys Gly Asp Thr Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1055                 1060                 1065             


Glu Ser  Ile Phe Asp Lys Ile  Tyr Ser Thr Lys Ser  Asp Val Trp 
    1070                 1075                 1080             


Ser Tyr  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Gly Ser 
    1085                 1090                 1095             


Pro Tyr  Pro Gly Val Gln Met  Asp Glu Asp Phe Cys  Ser Arg Leu 
    1100                 1105                 1110             


Arg Glu  Gly Met Arg Met Arg  Ala Pro Glu Tyr Ser  Thr Pro Glu 
    1115                 1120                 1125             


Ile Tyr  Gln Ile Met Leu Asp  Cys Trp His Arg Asp  Pro Lys Glu 
    1130                 1135                 1140             


Arg Pro  Arg Phe Ala Glu Leu  Val Glu Lys Leu Gly  Asp Leu Leu 
    1145                 1150                 1155             


Gln Ala  Asn Val Gln Gln Asp  Gly Lys Asp Tyr Ile  Pro Ile Asn 
    1160                 1165                 1170             


Ala Ile  Leu Thr Gly Asn Ser  Gly Phe Thr Tyr Ser  Thr Pro Ala 
    1175                 1180                 1185             


Phe Ser  Glu Asp Phe Phe Lys  Glu Ser Ile Ser Ala  Pro Lys Phe 
    1190                 1195                 1200             


Asn Ser  Gly Ser Ser Asp Asp  Val Arg Tyr Val Asn  Ala Phe Lys 
    1205                 1210                 1215             


Phe Met  Ser Leu Glu Arg Ile  Lys Thr Phe Glu Glu  Leu Leu Pro 
    1220                 1225                 1230             


Asn Ala  Thr Ser Met Phe Asp  Asp Tyr Gln Gly Asp  Ser Ser Thr 
    1235                 1240                 1245             


Leu Leu  Ala Ser Pro Met Leu  Lys Arg Phe Thr Trp  Thr Asp Ser 
    1250                 1255                 1260             


Lys Pro  Lys Ala Ser Leu Lys  Ile Asp Leu Arg Val  Thr Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Ser Gly Leu Ser  Asp Val Ser Arg Pro  Ser Phe Cys 
    1280                 1285                 1290             


His Ser  Ser Cys Gly His Val  Ser Glu Gly Lys Arg  Arg Phe Thr 
    1295                 1300                 1305             


Tyr Asp  His Ala Glu Leu Glu  Arg Lys Ile Ala Cys  Cys Ser Pro 
    1310                 1315                 1320             


Pro Pro  Asp Tyr Asn Ser Val  Val Leu Tyr Ser Thr  Pro Pro Ile 
    1325                 1330                 1335             


<210> 12
<211> 758
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu 
        755             


<210> 13
<211> 1312
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Ser Lys Leu Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile 
1               5                   10                  15      


Met Gln Ala Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala 
            20                  25                  30          


His Lys Trp Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu 
        35                  40                  45              


Ser Ile Thr Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser 
    50                  55                  60                  


Thr Leu Thr Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser 
65                  70                  75                  80  


Cys Lys Tyr Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser 
                85                  90                  95      


Ala Ile Tyr Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met 
            100                 105                 110         


Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu 
        115                 120                 125             


Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys 
    130                 135                 140                 


Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp 
145                 150                 155                 160 


Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile 
                165                 170                 175     


Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr 
            180                 185                 190         


Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Gln Ile 
        195                 200                 205             


Ser Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu 
    210                 215                 220                 


Asn Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp 
225                 230                 235                 240 


Ser Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile 
                245                 250                 255     


Asp Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile 
            260                 265                 270         


Asp Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg 
        275                 280                 285             


Ser Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp 
    290                 295                 300                 


Lys Ala Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr 
305                 310                 315                 320 


Val Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe 
                325                 330                 335     


Pro Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu 
            340                 345                 350         


Lys Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp 
        355                 360                 365             


Val Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys 
    370                 375                 380                 


Gln Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val 
385                 390                 395                 400 


Lys Pro Gln Ile Tyr Glu Lys Ala Val Ser Ser Phe Pro Asp Pro Ala 
                405                 410                 415     


Leu Tyr Pro Leu Gly Ser Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly 
            420                 425                 430         


Ile Pro Gln Pro Thr Ile Lys Trp Phe Trp His Pro Cys Asn His Asn 
        435                 440                 445             


His Ser Glu Ala Arg Cys Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe 
    450                 455                 460                 


Ile Leu Asp Ala Asp Ser Asn Met Gly Asn Arg Ile Glu Ser Ile Thr 
465                 470                 475                 480 


Gln Arg Met Ala Ile Ile Glu Gly Lys Asn Lys Met Ala Ser Thr Leu 
                485                 490                 495     


Val Val Ala Asp Ser Arg Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser 
            500                 505                 510         


Asn Lys Val Gly Thr Val Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp 
        515                 520                 525             


Val Pro Asn Gly Phe His Val Asn Leu Glu Lys Met Pro Thr Glu Gly 
    530                 535                 540                 


Glu Asp Leu Lys Leu Ser Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp 
545                 550                 555                 560 


Val Thr Trp Ile Leu Leu Arg Thr Val Asn Asn Arg Thr Met His Tyr 
                565                 570                 575     


Ser Ile Ser Lys Gln Lys Met Ala Ile Thr Lys Glu His Ser Ile Thr 
            580                 585                 590         


Leu Asn Leu Thr Ile Met Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr 
        595                 600                 605             


Ala Cys Arg Ala Arg Asn Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys 
    610                 615                 620                 


Lys Glu Ile Thr Ile Arg Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn 
625                 630                 635                 640 


Leu Ser Asp His Thr Val Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys 
                645                 650                 655     


His Ala Asn Gly Val Pro Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn 
            660                 665                 670         


His Lys Ile Gln Gln Glu Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser 
        675                 680                 685             


Thr Leu Phe Ile Glu Arg Val Thr Glu Glu Asp Glu Gly Val Tyr His 
    690                 695                 700                 


Cys Lys Ala Thr Asn Gln Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu 
705                 710                 715                 720 


Thr Val Gln Gly Thr Ser Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu 
                725                 730                 735     


Thr Cys Thr Cys Val Ala Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu 
            740                 745                 750         


Phe Ile Arg Lys Met Lys Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr 
        755                 760                 765             


Leu Ser Ile Ile Met Asp Pro Asp Glu Val Pro Leu Asp Glu Gln Cys 
    770                 775                 780                 


Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg 
785                 790                 795                 800 


Leu Lys Leu Gly Lys Ser Leu Gly Arg Gly Ala Phe Gly Lys Val Val 
                805                 810                 815     


Gln Ala Ser Ala Phe Gly Ile Lys Lys Ser Pro Thr Cys Arg Thr Val 
            820                 825                 830         


Ala Val Lys Met Leu Lys Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala 
        835                 840                 845             


Leu Met Thr Glu Leu Lys Ile Leu Thr His Ile Gly His His Leu Asn 
    850                 855                 860                 


Val Val Asn Leu Leu Gly Ala Cys Thr Lys Gln Gly Gly Pro Leu Met 
865                 870                 875                 880 


Val Ile Val Glu Tyr Cys Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys 
                885                 890                 895     


Ser Lys Arg Asp Leu Phe Phe Leu Asn Lys Asp Ala Ala Leu His Met 
            900                 905                 910         


Glu Pro Lys Lys Glu Lys Met Glu Pro Gly Leu Glu Gln Gly Lys Lys 
        915                 920                 925             


Pro Arg Leu Asp Ser Val Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly 
    930                 935                 940                 


Phe Gln Glu Asp Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Asp Ser 
945                 950                 955                 960 


Asp Gly Phe Tyr Lys Glu Pro Ile Thr Met Glu Asp Leu Ile Ser Tyr 
                965                 970                 975     


Ser Phe Gln Val Ala Arg Gly Met Glu Phe Leu Ser Ser Arg Lys Cys 
            980                 985                 990         


Ile His Arg Asp Leu Ala Ala Arg  Asn Ile Leu Leu Ser  Glu Asn Asn 
        995                 1000                 1005             


Val Val  Lys Ile Cys Asp Phe  Gly Leu Ala Arg Asp  Ile Tyr Lys 
    1010                 1015                 1020             


Asn Pro  Asp Tyr Val Arg Lys  Gly Asp Thr Arg Leu  Pro Leu Lys 
    1025                 1030                 1035             


Trp Met  Ala Pro Glu Ser Ile  Phe Asp Lys Ile Tyr  Ser Thr Lys 
    1040                 1045                 1050             


Ser Asp  Val Trp Ser Tyr Gly  Val Leu Leu Trp Glu  Ile Phe Ser 
    1055                 1060                 1065             


Leu Gly  Gly Ser Pro Tyr Pro  Gly Val Gln Met Asp  Glu Asp Phe 
    1070                 1075                 1080             


Cys Ser  Arg Leu Arg Glu Gly  Met Arg Met Arg Ala  Pro Glu Tyr 
    1085                 1090                 1095             


Ser Thr  Pro Glu Ile Tyr Gln  Ile Met Leu Asp Cys  Trp His Arg 
    1100                 1105                 1110             


Asp Pro  Lys Glu Arg Pro Arg  Phe Ala Glu Leu Val  Glu Lys Leu 
    1115                 1120                 1125             


Gly Asp  Leu Leu Gln Ala Asn  Val Gln Gln Asp Gly  Lys Asp Tyr 
    1130                 1135                 1140             


Ile Pro  Ile Asn Ala Ile Leu  Thr Gly Asn Ser Gly  Phe Thr Tyr 
    1145                 1150                 1155             


Ser Thr  Pro Ala Phe Ser Glu  Asp Phe Phe Lys Glu  Ser Ile Ser 
    1160                 1165                 1170             


Ala Pro  Lys Phe Asn Ser Gly  Ser Ser Asp Asp Val  Arg Tyr Val 
    1175                 1180                 1185             


Asn Ala  Phe Lys Phe Met Ser  Leu Glu Arg Ile Lys  Thr Phe Glu 
    1190                 1195                 1200             


Glu Leu  Leu Pro Asn Ala Thr  Ser Met Phe Asp Asp  Tyr Gln Gly 
    1205                 1210                 1215             


Asp Ser  Ser Thr Leu Leu Ala  Ser Pro Met Leu Lys  Arg Phe Thr 
    1220                 1225                 1230             


Trp Thr  Asp Ser Lys Pro Lys  Ala Ser Leu Lys Ile  Asp Leu Arg 
    1235                 1240                 1245             


Val Thr  Ser Lys Ser Lys Glu  Ser Gly Leu Ser Asp  Val Ser Arg 
    1250                 1255                 1260             


Pro Ser  Phe Cys His Ser Ser  Cys Gly His Val Ser  Glu Gly Lys 
    1265                 1270                 1275             


Arg Arg  Phe Thr Tyr Asp His  Ala Glu Leu Glu Arg  Lys Ile Ala 
    1280                 1285                 1290             


Cys Cys  Ser Pro Pro Pro Asp  Tyr Asn Ser Val Val  Leu Tyr Ser 
    1295                 1300                 1305             


Thr Pro  Pro Ile 
    1310         


