                         SEQUENCE LISTING

<110>  Technical University of Denmark
 
<120>  A novel cell-based platform for converting lactose containing 
       feedstocks into value-added compounds

<130>  P2371PC00

<150>  EP18163608.5
<151>  2018-03-23

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  1905
<212>  DNA
<213>  Streptococcus thermophilus LMD-9


<220>
<221>  CDS
<222>  (1)..(1905)
<223>  LacS gene encoding lac-transporter

<300>
<308>  GenBank CP000419.1
<309>  2014-01-28
<313>  (1273959)..(1275863)

<400>  1
atg gaa aaa tct aaa ggt cag atg aag tct cgt tta tcc tac gca gct         48
Met Glu Lys Ser Lys Gly Gln Met Lys Ser Arg Leu Ser Tyr Ala Ala           
1               5                   10                  15                

ggt gct ttt ggt aac gac gtc ttc tat gca acc ttg tca aca tac ttt         96
Gly Ala Phe Gly Asn Asp Val Phe Tyr Ala Thr Leu Ser Thr Tyr Phe           
            20                  25                  30                    

atc atg ttt gtg aca act cac ttg ttt aac aca ggt gat cca aag caa        144
Ile Met Phe Val Thr Thr His Leu Phe Asn Thr Gly Asp Pro Lys Gln           
        35                  40                  45                        

aat agt cac tac gta cta tta atc act aac att atc tct att ttg cgt        192
Asn Ser His Tyr Val Leu Leu Ile Thr Asn Ile Ile Ser Ile Leu Arg           
    50                  55                  60                            

atc ttg gaa gta ttt atc gat cca ttg atc ggt aat atg att gat aac        240
Ile Leu Glu Val Phe Ile Asp Pro Leu Ile Gly Asn Met Ile Asp Asn           
65                  70                  75                  80            

act aat act aag tat ggt aaa ttc aaa cca tgg gta gtt ggt ggt ggt        288
Thr Asn Thr Lys Tyr Gly Lys Phe Lys Pro Trp Val Val Gly Gly Gly           
                85                  90                  95                

atc atc agt tct atc acc ttg ttg ctt ctc ttc acc gat tta ggt ggt        336
Ile Ile Ser Ser Ile Thr Leu Leu Leu Leu Phe Thr Asp Leu Gly Gly           
            100                 105                 110                   

ttg aat aaa aca aat cct ttc ttg tac ctt gta ctt ttt gga att atc        384
Leu Asn Lys Thr Asn Pro Phe Leu Tyr Leu Val Leu Phe Gly Ile Ile           
        115                 120                 125                       

tac ctt ata atg gat gtc ttc tac tcg att aaa gat atc ggt ttc tgg        432
Tyr Leu Ile Met Asp Val Phe Tyr Ser Ile Lys Asp Ile Gly Phe Trp           
    130                 135                 140                           

tca atg ctt cct gcc ttg tct ctt gac agt cac gaa cgt gaa aaa atg        480
Ser Met Leu Pro Ala Leu Ser Leu Asp Ser His Glu Arg Glu Lys Met           
145                 150                 155                 160           

gca act ttt gcc cgt att ggt tct acg att ggt gcc aat att gta ggt        528
Ala Thr Phe Ala Arg Ile Gly Ser Thr Ile Gly Ala Asn Ile Val Gly           
                165                 170                 175               

gtt gcc atc atg cca atc gtt ttg ttc ttc tct atg acg aac agt agt        576
Val Ala Ile Met Pro Ile Val Leu Phe Phe Ser Met Thr Asn Ser Ser           
            180                 185                 190                   

ggc tct gga gat aaa tct gga tgg ttc tgg ttt gca ttt atc gtt gca        624
Gly Ser Gly Asp Lys Ser Gly Trp Phe Trp Phe Ala Phe Ile Val Ala           
        195                 200                 205                       

ctc att ggt gtg att aca tca att gct gtt ggt att ggt aca cgt gaa        672
Leu Ile Gly Val Ile Thr Ser Ile Ala Val Gly Ile Gly Thr Arg Glu           
    210                 215                 220                           

gtt gag tca aaa ctt cgt gat aac aat gaa aaa act agc ctt aaa caa        720
Val Glu Ser Lys Leu Arg Asp Asn Asn Glu Lys Thr Ser Leu Lys Gln           
225                 230                 235                 240           

gtc ttt aaa gtt ctt ggt aaa aac gac caa ttg atg tgg ctg tct ctc        768
Val Phe Lys Val Leu Gly Lys Asn Asp Gln Leu Met Trp Leu Ser Leu           
                245                 250                 255               

gga tat tgg ttc tat ggt ctt ggt att aat aca ctt aat gct ctt caa        816
Gly Tyr Trp Phe Tyr Gly Leu Gly Ile Asn Thr Leu Asn Ala Leu Gln           
            260                 265                 270                   

ctt tat tac ttc aca ttt atc ctt ggt gat tca ggg aaa tac tca atc        864
Leu Tyr Tyr Phe Thr Phe Ile Leu Gly Asp Ser Gly Lys Tyr Ser Ile           
        275                 280                 285                       

ctt tac gga ttg aat aca gtt gtt ggt ttg gtt tca gtt tca ctg ttc        912
Leu Tyr Gly Leu Asn Thr Val Val Gly Leu Val Ser Val Ser Leu Phe           
    290                 295                 300                           

cct agt ctt gct ggt aaa ttc aac cgt aaa cgt ttg ttc tat gga tgt        960
Pro Ser Leu Ala Gly Lys Phe Asn Arg Lys Arg Leu Phe Tyr Gly Cys           
305                 310                 315                 320           

att gca gta atg ctc ggt ggt atc gga atc ttt agt att gca ggt act       1008
Ile Ala Val Met Leu Gly Gly Ile Gly Ile Phe Ser Ile Ala Gly Thr           
                325                 330                 335               

tca ctt cca atg atc ttg act gca gct gaa ctc ttc ttc att cca caa       1056
Ser Leu Pro Met Ile Leu Thr Ala Ala Glu Leu Phe Phe Ile Pro Gln           
            340                 345                 350                   

cct ctt gtg ttc ctt gtt atc ctt atg att atc tct gac tca gta gaa       1104
Pro Leu Val Phe Leu Val Ile Leu Met Ile Ile Ser Asp Ser Val Glu           
        355                 360                 365                       

tat ggt caa tgg aaa ttg gga cac cgt gat gaa tca ctt act ttg tca       1152
Tyr Gly Gln Trp Lys Leu Gly His Arg Asp Glu Ser Leu Thr Leu Ser           
    370                 375                 380                           

gtt cgt cca ctt gtt gat aaa ctt ggt ggt gcg atg tca aac tgg ctt       1200
Val Arg Pro Leu Val Asp Lys Leu Gly Gly Ala Met Ser Asn Trp Leu           
385                 390                 395                 400           

gtt tct aca att gcc gta gct gcc ggt atg aca aca ggt gcc tca gca       1248
Val Ser Thr Ile Ala Val Ala Ala Gly Met Thr Thr Gly Ala Ser Ala           
                405                 410                 415               

tca aca att aca aca cat caa cag tct att ttt aag ctt agc atg ttt       1296
Ser Thr Ile Thr Thr His Gln Gln Ser Ile Phe Lys Leu Ser Met Phe           
            420                 425                 430                   

ggt ttc cca gca gca gca atg ctt atc ggt gcc ttc att att gct cgt       1344
Gly Phe Pro Ala Ala Ala Met Leu Ile Gly Ala Phe Ile Ile Ala Arg           
        435                 440                 445                       

aaa atc act ttg act gaa gca cgt cac gct aaa att gtt gaa gaa ttg       1392
Lys Ile Thr Leu Thr Glu Ala Arg His Ala Lys Ile Val Glu Glu Leu           
    450                 455                 460                           

gaa cat cgc ttt agc gta gca act tct gaa aat gaa gtt aaa gct aac       1440
Glu His Arg Phe Ser Val Ala Thr Ser Glu Asn Glu Val Lys Ala Asn           
465                 470                 475                 480           

gtc gta tct ctt gta acc cct aca act ggt tat ttg gtt gat ctc tca       1488
Val Val Ser Leu Val Thr Pro Thr Thr Gly Tyr Leu Val Asp Leu Ser           
                485                 490                 495               

agt gtt aat gat gaa cac ttt gct tca ggt agc atg ggt aaa ggt ttc       1536
Ser Val Asn Asp Glu His Phe Ala Ser Gly Ser Met Gly Lys Gly Phe           
            500                 505                 510                   

gcc att aaa cct act gat gga gct gtc ttt gca cca att agt ggt acc       1584
Ala Ile Lys Pro Thr Asp Gly Ala Val Phe Ala Pro Ile Ser Gly Thr           
        515                 520                 525                       

att cgt caa att ctt cct act cgc cat gca gtt ggt att gaa agt gaa       1632
Ile Arg Gln Ile Leu Pro Thr Arg His Ala Val Gly Ile Glu Ser Glu           
    530                 535                 540                           

gat ggt gtc att gtt ctt atc cac gtt ggc atc gga aca gtt aaa ctt       1680
Asp Gly Val Ile Val Leu Ile His Val Gly Ile Gly Thr Val Lys Leu           
545                 550                 555                 560           

aat ggt gaa gga ttc att agt tac gta gaa caa ggt gat cgt gtt gaa       1728
Asn Gly Glu Gly Phe Ile Ser Tyr Val Glu Gln Gly Asp Arg Val Glu           
                565                 570                 575               

gtt gga caa aaa ctt ctt gag ttc tgg tca cca att att gag aaa aat       1776
Val Gly Gln Lys Leu Leu Glu Phe Trp Ser Pro Ile Ile Glu Lys Asn           
            580                 585                 590                   

ggt ctt gat gac aca gta ctt gtc act gta act aat tca gaa aaa ttc       1824
Gly Leu Asp Asp Thr Val Leu Val Thr Val Thr Asn Ser Glu Lys Phe           
        595                 600                 605                       

agt gct ttc cat ctt gaa caa aaa gtt gga gaa aag gta gaa gct ttg       1872
Ser Ala Phe His Leu Glu Gln Lys Val Gly Glu Lys Val Glu Ala Leu           
    610                 615                 620                           

tct gaa gtt att acc ttc aaa aaa gga gaa taa                           1905
Ser Glu Val Ile Thr Phe Lys Lys Gly Glu                                   
625                 630                                                   


<210>  2
<211>  634
<212>  PRT
<213>  Streptococcus thermophilus LMD-9

<400>  2

Met Glu Lys Ser Lys Gly Gln Met Lys Ser Arg Leu Ser Tyr Ala Ala 
1               5                   10                  15      


Gly Ala Phe Gly Asn Asp Val Phe Tyr Ala Thr Leu Ser Thr Tyr Phe 
            20                  25                  30          


Ile Met Phe Val Thr Thr His Leu Phe Asn Thr Gly Asp Pro Lys Gln 
        35                  40                  45              


Asn Ser His Tyr Val Leu Leu Ile Thr Asn Ile Ile Ser Ile Leu Arg 
    50                  55                  60                  


Ile Leu Glu Val Phe Ile Asp Pro Leu Ile Gly Asn Met Ile Asp Asn 
65                  70                  75                  80  


Thr Asn Thr Lys Tyr Gly Lys Phe Lys Pro Trp Val Val Gly Gly Gly 
                85                  90                  95      


Ile Ile Ser Ser Ile Thr Leu Leu Leu Leu Phe Thr Asp Leu Gly Gly 
            100                 105                 110         


Leu Asn Lys Thr Asn Pro Phe Leu Tyr Leu Val Leu Phe Gly Ile Ile 
        115                 120                 125             


Tyr Leu Ile Met Asp Val Phe Tyr Ser Ile Lys Asp Ile Gly Phe Trp 
    130                 135                 140                 


Ser Met Leu Pro Ala Leu Ser Leu Asp Ser His Glu Arg Glu Lys Met 
145                 150                 155                 160 


Ala Thr Phe Ala Arg Ile Gly Ser Thr Ile Gly Ala Asn Ile Val Gly 
                165                 170                 175     


Val Ala Ile Met Pro Ile Val Leu Phe Phe Ser Met Thr Asn Ser Ser 
            180                 185                 190         


Gly Ser Gly Asp Lys Ser Gly Trp Phe Trp Phe Ala Phe Ile Val Ala 
        195                 200                 205             


Leu Ile Gly Val Ile Thr Ser Ile Ala Val Gly Ile Gly Thr Arg Glu 
    210                 215                 220                 


Val Glu Ser Lys Leu Arg Asp Asn Asn Glu Lys Thr Ser Leu Lys Gln 
225                 230                 235                 240 


Val Phe Lys Val Leu Gly Lys Asn Asp Gln Leu Met Trp Leu Ser Leu 
                245                 250                 255     


Gly Tyr Trp Phe Tyr Gly Leu Gly Ile Asn Thr Leu Asn Ala Leu Gln 
            260                 265                 270         


Leu Tyr Tyr Phe Thr Phe Ile Leu Gly Asp Ser Gly Lys Tyr Ser Ile 
        275                 280                 285             


Leu Tyr Gly Leu Asn Thr Val Val Gly Leu Val Ser Val Ser Leu Phe 
    290                 295                 300                 


Pro Ser Leu Ala Gly Lys Phe Asn Arg Lys Arg Leu Phe Tyr Gly Cys 
305                 310                 315                 320 


Ile Ala Val Met Leu Gly Gly Ile Gly Ile Phe Ser Ile Ala Gly Thr 
                325                 330                 335     


Ser Leu Pro Met Ile Leu Thr Ala Ala Glu Leu Phe Phe Ile Pro Gln 
            340                 345                 350         


Pro Leu Val Phe Leu Val Ile Leu Met Ile Ile Ser Asp Ser Val Glu 
        355                 360                 365             


Tyr Gly Gln Trp Lys Leu Gly His Arg Asp Glu Ser Leu Thr Leu Ser 
    370                 375                 380                 


Val Arg Pro Leu Val Asp Lys Leu Gly Gly Ala Met Ser Asn Trp Leu 
385                 390                 395                 400 


Val Ser Thr Ile Ala Val Ala Ala Gly Met Thr Thr Gly Ala Ser Ala 
                405                 410                 415     


Ser Thr Ile Thr Thr His Gln Gln Ser Ile Phe Lys Leu Ser Met Phe 
            420                 425                 430         


Gly Phe Pro Ala Ala Ala Met Leu Ile Gly Ala Phe Ile Ile Ala Arg 
        435                 440                 445             


Lys Ile Thr Leu Thr Glu Ala Arg His Ala Lys Ile Val Glu Glu Leu 
    450                 455                 460                 


Glu His Arg Phe Ser Val Ala Thr Ser Glu Asn Glu Val Lys Ala Asn 
465                 470                 475                 480 


Val Val Ser Leu Val Thr Pro Thr Thr Gly Tyr Leu Val Asp Leu Ser 
                485                 490                 495     


Ser Val Asn Asp Glu His Phe Ala Ser Gly Ser Met Gly Lys Gly Phe 
            500                 505                 510         


Ala Ile Lys Pro Thr Asp Gly Ala Val Phe Ala Pro Ile Ser Gly Thr 
        515                 520                 525             


Ile Arg Gln Ile Leu Pro Thr Arg His Ala Val Gly Ile Glu Ser Glu 
    530                 535                 540                 


Asp Gly Val Ile Val Leu Ile His Val Gly Ile Gly Thr Val Lys Leu 
545                 550                 555                 560 


Asn Gly Glu Gly Phe Ile Ser Tyr Val Glu Gln Gly Asp Arg Val Glu 
                565                 570                 575     


Val Gly Gln Lys Leu Leu Glu Phe Trp Ser Pro Ile Ile Glu Lys Asn 
            580                 585                 590         


Gly Leu Asp Asp Thr Val Leu Val Thr Val Thr Asn Ser Glu Lys Phe 
        595                 600                 605             


Ser Ala Phe His Leu Glu Gln Lys Val Gly Glu Lys Val Glu Ala Leu 
    610                 615                 620                 


Ser Glu Val Ile Thr Phe Lys Lys Gly Glu 
625                 630                 


<210>  3
<211>  1905
<212>  DNA
<213>  Streptococcus salivarius strain HSISS4


<220>
<221>  CDS
<222>  (1)..(1905)
<223>  LacS gene encoding lac-transporter

<300>
<308>  GenBank CP013216.1
<309>  2016-03-09
<313>  (1344163)..(1346067)

<400>  3
atg gga aaa tct aaa ggt caa atg aag tct cgt cta tcc tat tca gct         48
Met Gly Lys Ser Lys Gly Gln Met Lys Ser Arg Leu Ser Tyr Ser Ala           
1               5                   10                  15                

ggt gct ttt ggt aac gac gtc ttc tat gca acg ttg tca aca tac ttt         96
Gly Ala Phe Gly Asn Asp Val Phe Tyr Ala Thr Leu Ser Thr Tyr Phe           
            20                  25                  30                    

atc atg ttt gtg aca act cac ttg ttt aac aca ggt gat cca aag caa        144
Ile Met Phe Val Thr Thr His Leu Phe Asn Thr Gly Asp Pro Lys Gln           
        35                  40                  45                        

aat agt cac tac gta cta tta att act aac atc atc gct att ttg cgt        192
Asn Ser His Tyr Val Leu Leu Ile Thr Asn Ile Ile Ala Ile Leu Arg           
    50                  55                  60                            

atc ttg gaa gta ttt atc gat cca ttg atc ggt aac atg att gat aac        240
Ile Leu Glu Val Phe Ile Asp Pro Leu Ile Gly Asn Met Ile Asp Asn           
65                  70                  75                  80            

act cat act aag tat ggt aaa ttc aaa cca tgg gta gtt ggt ggt ggt        288
Thr His Thr Lys Tyr Gly Lys Phe Lys Pro Trp Val Val Gly Gly Gly           
                85                  90                  95                

atc atc agt tct atc gcc ttg ttg ctt ctc ttc acc gat tta ggt ggt        336
Ile Ile Ser Ser Ile Ala Leu Leu Leu Leu Phe Thr Asp Leu Gly Gly           
            100                 105                 110                   

ttg aat aaa aca aat cct ttc ttg tac ctt gta ctt ttc gga att atc        384
Leu Asn Lys Thr Asn Pro Phe Leu Tyr Leu Val Leu Phe Gly Ile Ile           
        115                 120                 125                       

tac ctt gta atg gat gtc ttc tac tca att aaa gat atc ggt ttc tgg        432
Tyr Leu Val Met Asp Val Phe Tyr Ser Ile Lys Asp Ile Gly Phe Trp           
    130                 135                 140                           

tca atg att cct gcc ttg tct ctt gac agt cat gaa cgt gaa aaa atg        480
Ser Met Ile Pro Ala Leu Ser Leu Asp Ser His Glu Arg Glu Lys Met           
145                 150                 155                 160           

gca act ttt gcc cgt att ggt tct acg att ggt gcc aat att gta ggt        528
Ala Thr Phe Ala Arg Ile Gly Ser Thr Ile Gly Ala Asn Ile Val Gly           
                165                 170                 175               

gtt gcc atc atg cca atc gtt ttg ttc ttc tct atg acg aac agt agt        576
Val Ala Ile Met Pro Ile Val Leu Phe Phe Ser Met Thr Asn Ser Ser           
            180                 185                 190                   

ggc tct gga gat aaa tct gga tgg ttc tgg ttt gca ttt atc gtt gct        624
Gly Ser Gly Asp Lys Ser Gly Trp Phe Trp Phe Ala Phe Ile Val Ala           
        195                 200                 205                       

ctc att ggt gtg att aca tca att gct gtt ggt att ggt aca cgt gaa        672
Leu Ile Gly Val Ile Thr Ser Ile Ala Val Gly Ile Gly Thr Arg Glu           
    210                 215                 220                           

gtt gag tca aaa ctt cgt gat aac aaa gaa aaa act agc ctt aaa caa        720
Val Glu Ser Lys Leu Arg Asp Asn Lys Glu Lys Thr Ser Leu Lys Gln           
225                 230                 235                 240           

gtc ttt aaa gtt ctt ggt aaa aac gac caa ttg atg tgg ttg tct ctc        768
Val Phe Lys Val Leu Gly Lys Asn Asp Gln Leu Met Trp Leu Ser Leu           
                245                 250                 255               

gga tat tgg ttc tat ggt ctt ggt att aat aca ctt aat gct ctt caa        816
Gly Tyr Trp Phe Tyr Gly Leu Gly Ile Asn Thr Leu Asn Ala Leu Gln           
            260                 265                 270                   

ctt ttt tac ttc aca ttt atc ctt ggt gat cca ggg aaa tac tca atc        864
Leu Phe Tyr Phe Thr Phe Ile Leu Gly Asp Pro Gly Lys Tyr Ser Ile           
        275                 280                 285                       

ctt tac gga ttg aat aca gtt gtt ggt ttg gtt tca gtt tca ctc ttc        912
Leu Tyr Gly Leu Asn Thr Val Val Gly Leu Val Ser Val Ser Leu Phe           
    290                 295                 300                           

cct agc cta gct ggt aaa ttc aac cgt aaa cgt ttg ttc tat gga tgt        960
Pro Ser Leu Ala Gly Lys Phe Asn Arg Lys Arg Leu Phe Tyr Gly Cys           
305                 310                 315                 320           

att gca gta atg ctc ggt ggt atc gga atc ttt agt att gca gga aca       1008
Ile Ala Val Met Leu Gly Gly Ile Gly Ile Phe Ser Ile Ala Gly Thr           
                325                 330                 335               

tca ctt cca atg atc ttg act gct gct gaa ctc ttc ttt att cca caa       1056
Ser Leu Pro Met Ile Leu Thr Ala Ala Glu Leu Phe Phe Ile Pro Gln           
            340                 345                 350                   

cct ctt gtg ttc ctt gtt atc ctc atg att atc tct gac tca gta gaa       1104
Pro Leu Val Phe Leu Val Ile Leu Met Ile Ile Ser Asp Ser Val Glu           
        355                 360                 365                       

tat ggt caa tgg aaa ttg gga cac cgt gat gaa tca ctt act ttg tca       1152
Tyr Gly Gln Trp Lys Leu Gly His Arg Asp Glu Ser Leu Thr Leu Ser           
    370                 375                 380                           

gtt cgt cca ctt gtt gat aaa ctt ggt ggt gcg atg tca aac tgg ctt       1200
Val Arg Pro Leu Val Asp Lys Leu Gly Gly Ala Met Ser Asn Trp Leu           
385                 390                 395                 400           

gtt tct aca att gcc gta gct gct ggt atg aca aca ggt gcc tca gca       1248
Val Ser Thr Ile Ala Val Ala Ala Gly Met Thr Thr Gly Ala Ser Ala           
                405                 410                 415               

tca aca att aca aca cat caa cag tct atc ttt aag ctt agc atg ttt       1296
Ser Thr Ile Thr Thr His Gln Gln Ser Ile Phe Lys Leu Ser Met Phe           
            420                 425                 430                   

ggt ttc cca gca gca gca atg ctt atc gga gcc ttc att att gct cgt       1344
Gly Phe Pro Ala Ala Ala Met Leu Ile Gly Ala Phe Ile Ile Ala Arg           
        435                 440                 445                       

aaa atc act ttg act gaa gca cgt cac gct gaa atc gtc gaa gaa ttg       1392
Lys Ile Thr Leu Thr Glu Ala Arg His Ala Glu Ile Val Glu Glu Leu           
    450                 455                 460                           

gaa cat cgc ttt agc gta gca act tct gaa aat gaa gtt aaa gct aac       1440
Glu His Arg Phe Ser Val Ala Thr Ser Glu Asn Glu Val Lys Ala Asn           
465                 470                 475                 480           

gtc gta tct ctt gta aac cct aca act ggt cat ttg gtt gac ctc tca       1488
Val Val Ser Leu Val Asn Pro Thr Thr Gly His Leu Val Asp Leu Ser           
                485                 490                 495               

agt gtt aat gat gaa cac ttt gct tca ggt agc atg ggt aaa ggt ttc       1536
Ser Val Asn Asp Glu His Phe Ala Ser Gly Ser Met Gly Lys Gly Phe           
            500                 505                 510                   

gcc att aaa cct act gat gga gct gtc ttt gca cca att agt ggt acc       1584
Ala Ile Lys Pro Thr Asp Gly Ala Val Phe Ala Pro Ile Ser Gly Thr           
        515                 520                 525                       

att cgt caa gtt ctt cct act cgc cat gca gtt ggt att gaa agt gaa       1632
Ile Arg Gln Val Leu Pro Thr Arg His Ala Val Gly Ile Glu Ser Glu           
    530                 535                 540                           

gat ggt gtc att gtt ctt atc cac gtt ggt atc gga aca gtt aaa ctt       1680
Asp Gly Val Ile Val Leu Ile His Val Gly Ile Gly Thr Val Lys Leu           
545                 550                 555                 560           

aaa ggt gaa ggg ttc att agt tac gta gaa caa ggt gat cgt gtt gaa       1728
Lys Gly Glu Gly Phe Ile Ser Tyr Val Glu Gln Gly Asp Arg Val Glu           
                565                 570                 575               

gtt gga caa aaa ctt ctt gag ttc tgg tca cca att att gag aaa aat       1776
Val Gly Gln Lys Leu Leu Glu Phe Trp Ser Pro Ile Ile Glu Lys Asn           
            580                 585                 590                   

ggt ctt gat gac aca gta ctt gtc act gta act aat tca gaa aaa ttc       1824
Gly Leu Asp Asp Thr Val Leu Val Thr Val Thr Asn Ser Glu Lys Phe           
        595                 600                 605                       

agt gct ttc cat ctt gaa caa gaa gtt gga gaa aag gta gaa gct ttg       1872
Ser Ala Phe His Leu Glu Gln Glu Val Gly Glu Lys Val Glu Ala Leu           
    610                 615                 620                           

tct gaa gtt att acc ttc aaa aaa gga gaa taa                           1905
Ser Glu Val Ile Thr Phe Lys Lys Gly Glu                                   
625                 630                                                   


<210>  4
<211>  634
<212>  PRT
<213>  Streptococcus salivarius strain HSISS4

<400>  4

Met Gly Lys Ser Lys Gly Gln Met Lys Ser Arg Leu Ser Tyr Ser Ala 
1               5                   10                  15      


Gly Ala Phe Gly Asn Asp Val Phe Tyr Ala Thr Leu Ser Thr Tyr Phe 
            20                  25                  30          


Ile Met Phe Val Thr Thr His Leu Phe Asn Thr Gly Asp Pro Lys Gln 
        35                  40                  45              


Asn Ser His Tyr Val Leu Leu Ile Thr Asn Ile Ile Ala Ile Leu Arg 
    50                  55                  60                  


Ile Leu Glu Val Phe Ile Asp Pro Leu Ile Gly Asn Met Ile Asp Asn 
65                  70                  75                  80  


Thr His Thr Lys Tyr Gly Lys Phe Lys Pro Trp Val Val Gly Gly Gly 
                85                  90                  95      


Ile Ile Ser Ser Ile Ala Leu Leu Leu Leu Phe Thr Asp Leu Gly Gly 
            100                 105                 110         


Leu Asn Lys Thr Asn Pro Phe Leu Tyr Leu Val Leu Phe Gly Ile Ile 
        115                 120                 125             


Tyr Leu Val Met Asp Val Phe Tyr Ser Ile Lys Asp Ile Gly Phe Trp 
    130                 135                 140                 


Ser Met Ile Pro Ala Leu Ser Leu Asp Ser His Glu Arg Glu Lys Met 
145                 150                 155                 160 


Ala Thr Phe Ala Arg Ile Gly Ser Thr Ile Gly Ala Asn Ile Val Gly 
                165                 170                 175     


Val Ala Ile Met Pro Ile Val Leu Phe Phe Ser Met Thr Asn Ser Ser 
            180                 185                 190         


Gly Ser Gly Asp Lys Ser Gly Trp Phe Trp Phe Ala Phe Ile Val Ala 
        195                 200                 205             


Leu Ile Gly Val Ile Thr Ser Ile Ala Val Gly Ile Gly Thr Arg Glu 
    210                 215                 220                 


Val Glu Ser Lys Leu Arg Asp Asn Lys Glu Lys Thr Ser Leu Lys Gln 
225                 230                 235                 240 


Val Phe Lys Val Leu Gly Lys Asn Asp Gln Leu Met Trp Leu Ser Leu 
                245                 250                 255     


Gly Tyr Trp Phe Tyr Gly Leu Gly Ile Asn Thr Leu Asn Ala Leu Gln 
            260                 265                 270         


Leu Phe Tyr Phe Thr Phe Ile Leu Gly Asp Pro Gly Lys Tyr Ser Ile 
        275                 280                 285             


Leu Tyr Gly Leu Asn Thr Val Val Gly Leu Val Ser Val Ser Leu Phe 
    290                 295                 300                 


Pro Ser Leu Ala Gly Lys Phe Asn Arg Lys Arg Leu Phe Tyr Gly Cys 
305                 310                 315                 320 


Ile Ala Val Met Leu Gly Gly Ile Gly Ile Phe Ser Ile Ala Gly Thr 
                325                 330                 335     


Ser Leu Pro Met Ile Leu Thr Ala Ala Glu Leu Phe Phe Ile Pro Gln 
            340                 345                 350         


Pro Leu Val Phe Leu Val Ile Leu Met Ile Ile Ser Asp Ser Val Glu 
        355                 360                 365             


Tyr Gly Gln Trp Lys Leu Gly His Arg Asp Glu Ser Leu Thr Leu Ser 
    370                 375                 380                 


Val Arg Pro Leu Val Asp Lys Leu Gly Gly Ala Met Ser Asn Trp Leu 
385                 390                 395                 400 


Val Ser Thr Ile Ala Val Ala Ala Gly Met Thr Thr Gly Ala Ser Ala 
                405                 410                 415     


Ser Thr Ile Thr Thr His Gln Gln Ser Ile Phe Lys Leu Ser Met Phe 
            420                 425                 430         


Gly Phe Pro Ala Ala Ala Met Leu Ile Gly Ala Phe Ile Ile Ala Arg 
        435                 440                 445             


Lys Ile Thr Leu Thr Glu Ala Arg His Ala Glu Ile Val Glu Glu Leu 
    450                 455                 460                 


Glu His Arg Phe Ser Val Ala Thr Ser Glu Asn Glu Val Lys Ala Asn 
465                 470                 475                 480 


Val Val Ser Leu Val Asn Pro Thr Thr Gly His Leu Val Asp Leu Ser 
                485                 490                 495     


Ser Val Asn Asp Glu His Phe Ala Ser Gly Ser Met Gly Lys Gly Phe 
            500                 505                 510         


Ala Ile Lys Pro Thr Asp Gly Ala Val Phe Ala Pro Ile Ser Gly Thr 
        515                 520                 525             


Ile Arg Gln Val Leu Pro Thr Arg His Ala Val Gly Ile Glu Ser Glu 
    530                 535                 540                 


Asp Gly Val Ile Val Leu Ile His Val Gly Ile Gly Thr Val Lys Leu 
545                 550                 555                 560 


Lys Gly Glu Gly Phe Ile Ser Tyr Val Glu Gln Gly Asp Arg Val Glu 
                565                 570                 575     


Val Gly Gln Lys Leu Leu Glu Phe Trp Ser Pro Ile Ile Glu Lys Asn 
            580                 585                 590         


Gly Leu Asp Asp Thr Val Leu Val Thr Val Thr Asn Ser Glu Lys Phe 
        595                 600                 605             


Ser Ala Phe His Leu Glu Gln Glu Val Gly Glu Lys Val Glu Ala Leu 
    610                 615                 620                 


Ser Glu Val Ile Thr Phe Lys Lys Gly Glu 
625                 630                 


<210>  5
<211>  1905
<212>  DNA
<213>  Streptococcus infantarius subsp. infantarius strain CJ18


<220>
<221>  CDS
<222>  (1)..(1905)
<223>  LacS gene encoding lac-transporter

<300>
<308>  GenBank CP003295.1
<309>  2014-01-31
<313>  (959441)..(961345)

<400>  5
atg aga aaa tct aac gtt cag atg aag tct cgt cta tcc tat gca gcg         48
Met Arg Lys Ser Asn Val Gln Met Lys Ser Arg Leu Ser Tyr Ala Ala           
1               5                   10                  15                

ggt gct ttt ggt aac gac gtc ttc tat gca acg ttg tca aca tac ttt         96
Gly Ala Phe Gly Asn Asp Val Phe Tyr Ala Thr Leu Ser Thr Tyr Phe           
            20                  25                  30                    

att atg ttt gtg aca act cac ttg ttt aac aca ggt gat cca aag caa        144
Ile Met Phe Val Thr Thr His Leu Phe Asn Thr Gly Asp Pro Lys Gln           
        35                  40                  45                        

aat agt cac tat gta cta tta att act aac atc atc tct att ttg cgt        192
Asn Ser His Tyr Val Leu Leu Ile Thr Asn Ile Ile Ser Ile Leu Arg           
    50                  55                  60                            

atc ttg gaa gta ttt atc gat cca ttg atc ggt aac atg att gat aat        240
Ile Leu Glu Val Phe Ile Asp Pro Leu Ile Gly Asn Met Ile Asp Asn           
65                  70                  75                  80            

act cat acc aag tat ggt aaa ttc aaa cca tgg gta gtt ggt ggt ggt        288
Thr His Thr Lys Tyr Gly Lys Phe Lys Pro Trp Val Val Gly Gly Gly           
                85                  90                  95                

atc atc agt tct atc acc ttg ttg ctt ctc ttc acc gat tta ggt ggt        336
Ile Ile Ser Ser Ile Thr Leu Leu Leu Leu Phe Thr Asp Leu Gly Gly           
            100                 105                 110                   

ttg aat aaa aca aat cct ttc ttg tac ctt gta ctt ttc gga att atc        384
Leu Asn Lys Thr Asn Pro Phe Leu Tyr Leu Val Leu Phe Gly Ile Ile           
        115                 120                 125                       

tac ctt gta atg gat gtc ttc tac tca att aaa gat atc ggt ttc tgg        432
Tyr Leu Val Met Asp Val Phe Tyr Ser Ile Lys Asp Ile Gly Phe Trp           
    130                 135                 140                           

tca atg att cct gcc ttg tct ttt gac agt cat gaa cgt gaa aaa atg        480
Ser Met Ile Pro Ala Leu Ser Phe Asp Ser His Glu Arg Glu Lys Met           
145                 150                 155                 160           

gca act ttt gcc cgt att ggt tct acg att ggt gcc aat att gta ggt        528
Ala Thr Phe Ala Arg Ile Gly Ser Thr Ile Gly Ala Asn Ile Val Gly           
                165                 170                 175               

gtt gcc att atg cca atc gtt ttg ttc ttc tct atg acg aac agt agt        576
Val Ala Ile Met Pro Ile Val Leu Phe Phe Ser Met Thr Asn Ser Ser           
            180                 185                 190                   

ggc tct gga gat aaa tct gga tgg ttc tgg ttt gca ttt atc gtt gct        624
Gly Ser Gly Asp Lys Ser Gly Trp Phe Trp Phe Ala Phe Ile Val Ala           
        195                 200                 205                       

ctc att ggt gtg att aca tca att gct gtt ggt att ggt aca cgt gaa        672
Leu Ile Gly Val Ile Thr Ser Ile Ala Val Gly Ile Gly Thr Arg Glu           
    210                 215                 220                           

gtt gag tca aaa ctt cgt gat aac aat gaa aaa act agc ctt aaa caa        720
Val Glu Ser Lys Leu Arg Asp Asn Asn Glu Lys Thr Ser Leu Lys Gln           
225                 230                 235                 240           

gtc ttt aaa gtt ctt ggt aaa aac gac caa ttg atg tgg ttg tct ctc        768
Val Phe Lys Val Leu Gly Lys Asn Asp Gln Leu Met Trp Leu Ser Leu           
                245                 250                 255               

gga tat tgg ttc tat ggt ctt ggt att aat aca ctt aat gct ctt caa        816
Gly Tyr Trp Phe Tyr Gly Leu Gly Ile Asn Thr Leu Asn Ala Leu Gln           
            260                 265                 270                   

ctt tat tac ttc aca ttt atc ctt ggt gat tca gga aaa tac tca atc        864
Leu Tyr Tyr Phe Thr Phe Ile Leu Gly Asp Ser Gly Lys Tyr Ser Ile           
        275                 280                 285                       

ctt tac gga ttg aat aca gtt gtt ggt ttg gtt tca gtt tca ctg ttc        912
Leu Tyr Gly Leu Asn Thr Val Val Gly Leu Val Ser Val Ser Leu Phe           
    290                 295                 300                           

cct agt ctt gct ggt aaa ttc aac cgt aaa cgt ttg ttc tat gga tgt        960
Pro Ser Leu Ala Gly Lys Phe Asn Arg Lys Arg Leu Phe Tyr Gly Cys           
305                 310                 315                 320           

att gca gta atg atc ggt ggt atc gga atc ttt agt att gca ggt act       1008
Ile Ala Val Met Ile Gly Gly Ile Gly Ile Phe Ser Ile Ala Gly Thr           
                325                 330                 335               

tca ctt cca att atc ttg act gca gct gaa ctc ttc ttc att cca caa       1056
Ser Leu Pro Ile Ile Leu Thr Ala Ala Glu Leu Phe Phe Ile Pro Gln           
            340                 345                 350                   

cct ctt gtg ttc ctt gtt atc ctt atg att atc tct gac tca gta gaa       1104
Pro Leu Val Phe Leu Val Ile Leu Met Ile Ile Ser Asp Ser Val Glu           
        355                 360                 365                       

tat ggt caa tgg aaa ttg gga cac cgt gat gaa tca ctt act ttg tca       1152
Tyr Gly Gln Trp Lys Leu Gly His Arg Asp Glu Ser Leu Thr Leu Ser           
    370                 375                 380                           

gtt cgt cca ctt gtt gat aaa ctt ggt ggt gcg atg tca aac tgg ctt       1200
Val Arg Pro Leu Val Asp Lys Leu Gly Gly Ala Met Ser Asn Trp Leu           
385                 390                 395                 400           

gtt tct aca att gcc gta gct gcc ggt atg aca aca ggt gcc tca gca       1248
Val Ser Thr Ile Ala Val Ala Ala Gly Met Thr Thr Gly Ala Ser Ala           
                405                 410                 415               

tca aca att aca aca cat caa cag tct att ttt aag ctt agc atg ttt       1296
Ser Thr Ile Thr Thr His Gln Gln Ser Ile Phe Lys Leu Ser Met Phe           
            420                 425                 430                   

ggt ttc cca gca gca aca atg ctc atc gga gtc ttc att att gct cgt       1344
Gly Phe Pro Ala Ala Thr Met Leu Ile Gly Val Phe Ile Ile Ala Arg           
        435                 440                 445                       

aaa atc act ttg act gaa gca cgt cac gct gaa att gtt gaa gaa ttg       1392
Lys Ile Thr Leu Thr Glu Ala Arg His Ala Glu Ile Val Glu Glu Leu           
    450                 455                 460                           

gaa tat cgc ttt agt gca gca act tct gaa aag gaa gtt aat gct aat       1440
Glu Tyr Arg Phe Ser Ala Ala Thr Ser Glu Lys Glu Val Asn Ala Asn           
465                 470                 475                 480           

aac gtt tct ctt gtg aac cct aca act ggt aaa cta gtt gat ctt tca       1488
Asn Val Ser Leu Val Asn Pro Thr Thr Gly Lys Leu Val Asp Leu Ser           
                485                 490                 495               

agc gtt agt gat aaa cgc ttt gct tca ggt agc cta ggt aaa gga ttt       1536
Ser Val Ser Asp Lys Arg Phe Ala Ser Gly Ser Leu Gly Lys Gly Phe           
            500                 505                 510                   

gca atc aaa cct tca gat ggt aag gtt ttt gcc cca att agt ggt aca       1584
Ala Ile Lys Pro Ser Asp Gly Lys Val Phe Ala Pro Ile Ser Gly Thr           
        515                 520                 525                       

gtt cgt cag att cta cct act cgt cat gcg att ggt att gaa agt gat       1632
Val Arg Gln Ile Leu Pro Thr Arg His Ala Ile Gly Ile Glu Ser Asp           
    530                 535                 540                           

gat ggt gtc gtt gtt ctc gta cac gtt ggt att gga aca gtt aaa ctt       1680
Asp Gly Val Val Val Leu Val His Val Gly Ile Gly Thr Val Lys Leu           
545                 550                 555                 560           

aaa ggt gaa ggg ttc att agt tac gta aaa caa ggt gaa cgt gtt gaa       1728
Lys Gly Glu Gly Phe Ile Ser Tyr Val Lys Gln Gly Glu Arg Val Glu           
                565                 570                 575               

gtt gga caa aaa ctt ctt gag ttc tgg tta cca att att gaa caa aat       1776
Val Gly Gln Lys Leu Leu Glu Phe Trp Leu Pro Ile Ile Glu Gln Asn           
            580                 585                 590                   

gga ttg gat gat aca gta ctt gtt att gta act aat tct gaa aaa ttc       1824
Gly Leu Asp Asp Thr Val Leu Val Ile Val Thr Asn Ser Glu Lys Phe           
        595                 600                 605                       

agt tct ttc caa ctt gaa caa aca gtt gga gaa gag gtt gaa gcc tta       1872
Ser Ser Phe Gln Leu Glu Gln Thr Val Gly Glu Glu Val Glu Ala Leu           
    610                 615                 620                           

tct gaa gtt att act ttt aaa aaa gga gaa taa                           1905
Ser Glu Val Ile Thr Phe Lys Lys Gly Glu                                   
625                 630                                                   


<210>  6
<211>  634
<212>  PRT
<213>  Streptococcus infantarius subsp. infantarius strain CJ18

<400>  6

Met Arg Lys Ser Asn Val Gln Met Lys Ser Arg Leu Ser Tyr Ala Ala 
1               5                   10                  15      


Gly Ala Phe Gly Asn Asp Val Phe Tyr Ala Thr Leu Ser Thr Tyr Phe 
            20                  25                  30          


Ile Met Phe Val Thr Thr His Leu Phe Asn Thr Gly Asp Pro Lys Gln 
        35                  40                  45              


Asn Ser His Tyr Val Leu Leu Ile Thr Asn Ile Ile Ser Ile Leu Arg 
    50                  55                  60                  


Ile Leu Glu Val Phe Ile Asp Pro Leu Ile Gly Asn Met Ile Asp Asn 
65                  70                  75                  80  


Thr His Thr Lys Tyr Gly Lys Phe Lys Pro Trp Val Val Gly Gly Gly 
                85                  90                  95      


Ile Ile Ser Ser Ile Thr Leu Leu Leu Leu Phe Thr Asp Leu Gly Gly 
            100                 105                 110         


Leu Asn Lys Thr Asn Pro Phe Leu Tyr Leu Val Leu Phe Gly Ile Ile 
        115                 120                 125             


Tyr Leu Val Met Asp Val Phe Tyr Ser Ile Lys Asp Ile Gly Phe Trp 
    130                 135                 140                 


Ser Met Ile Pro Ala Leu Ser Phe Asp Ser His Glu Arg Glu Lys Met 
145                 150                 155                 160 


Ala Thr Phe Ala Arg Ile Gly Ser Thr Ile Gly Ala Asn Ile Val Gly 
                165                 170                 175     


Val Ala Ile Met Pro Ile Val Leu Phe Phe Ser Met Thr Asn Ser Ser 
            180                 185                 190         


Gly Ser Gly Asp Lys Ser Gly Trp Phe Trp Phe Ala Phe Ile Val Ala 
        195                 200                 205             


Leu Ile Gly Val Ile Thr Ser Ile Ala Val Gly Ile Gly Thr Arg Glu 
    210                 215                 220                 


Val Glu Ser Lys Leu Arg Asp Asn Asn Glu Lys Thr Ser Leu Lys Gln 
225                 230                 235                 240 


Val Phe Lys Val Leu Gly Lys Asn Asp Gln Leu Met Trp Leu Ser Leu 
                245                 250                 255     


Gly Tyr Trp Phe Tyr Gly Leu Gly Ile Asn Thr Leu Asn Ala Leu Gln 
            260                 265                 270         


Leu Tyr Tyr Phe Thr Phe Ile Leu Gly Asp Ser Gly Lys Tyr Ser Ile 
        275                 280                 285             


Leu Tyr Gly Leu Asn Thr Val Val Gly Leu Val Ser Val Ser Leu Phe 
    290                 295                 300                 


Pro Ser Leu Ala Gly Lys Phe Asn Arg Lys Arg Leu Phe Tyr Gly Cys 
305                 310                 315                 320 


Ile Ala Val Met Ile Gly Gly Ile Gly Ile Phe Ser Ile Ala Gly Thr 
                325                 330                 335     


Ser Leu Pro Ile Ile Leu Thr Ala Ala Glu Leu Phe Phe Ile Pro Gln 
            340                 345                 350         


Pro Leu Val Phe Leu Val Ile Leu Met Ile Ile Ser Asp Ser Val Glu 
        355                 360                 365             


Tyr Gly Gln Trp Lys Leu Gly His Arg Asp Glu Ser Leu Thr Leu Ser 
    370                 375                 380                 


Val Arg Pro Leu Val Asp Lys Leu Gly Gly Ala Met Ser Asn Trp Leu 
385                 390                 395                 400 


Val Ser Thr Ile Ala Val Ala Ala Gly Met Thr Thr Gly Ala Ser Ala 
                405                 410                 415     


Ser Thr Ile Thr Thr His Gln Gln Ser Ile Phe Lys Leu Ser Met Phe 
            420                 425                 430         


Gly Phe Pro Ala Ala Thr Met Leu Ile Gly Val Phe Ile Ile Ala Arg 
        435                 440                 445             


Lys Ile Thr Leu Thr Glu Ala Arg His Ala Glu Ile Val Glu Glu Leu 
    450                 455                 460                 


Glu Tyr Arg Phe Ser Ala Ala Thr Ser Glu Lys Glu Val Asn Ala Asn 
465                 470                 475                 480 


Asn Val Ser Leu Val Asn Pro Thr Thr Gly Lys Leu Val Asp Leu Ser 
                485                 490                 495     


Ser Val Ser Asp Lys Arg Phe Ala Ser Gly Ser Leu Gly Lys Gly Phe 
            500                 505                 510         


Ala Ile Lys Pro Ser Asp Gly Lys Val Phe Ala Pro Ile Ser Gly Thr 
        515                 520                 525             


Val Arg Gln Ile Leu Pro Thr Arg His Ala Ile Gly Ile Glu Ser Asp 
    530                 535                 540                 


Asp Gly Val Val Val Leu Val His Val Gly Ile Gly Thr Val Lys Leu 
545                 550                 555                 560 


Lys Gly Glu Gly Phe Ile Ser Tyr Val Lys Gln Gly Glu Arg Val Glu 
                565                 570                 575     


Val Gly Gln Lys Leu Leu Glu Phe Trp Leu Pro Ile Ile Glu Gln Asn 
            580                 585                 590         


Gly Leu Asp Asp Thr Val Leu Val Ile Val Thr Asn Ser Glu Lys Phe 
        595                 600                 605             


Ser Ser Phe Gln Leu Glu Gln Thr Val Gly Glu Glu Val Glu Ala Leu 
    610                 615                 620                 


Ser Glu Val Ile Thr Phe Lys Lys Gly Glu 
625                 630                 


<210>  7
<211>  3081
<212>  DNA
<213>  Streptococcus thermophilus strain APC151


<220>
<221>  CDS
<222>  (1)..(3081)
<223>  LacZ gene encoding beta-galactosidase

<300>
<308>  GenBank CP019935.1
<309>  2017-03-03
<313>  (463146)..(466226)

<400>  7
atg aac atg act gaa aaa att caa act tat tta aac gat cca aag att         48
Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile           
1               5                   10                  15                

gtt agc gtt aat act gtt gat gct cac tca gat cat aag tat ttt gaa         96
Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu           
            20                  25                  30                    

tct ctt gaa gaa ttt tct gaa ggg gag atg aag tta aga caa tct ctt        144
Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu           
        35                  40                  45                        

aat gga aaa tgg aaa att cac tat gct cag aat aca aat cag gtt tta        192
Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu           
    50                  55                  60                            

aaa gac ttt tat aaa aca gaa ttt gat gaa act gat ttg aat ttc atc        240
Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile           
65                  70                  75                  80            

aat gta cca ggt cat tta gag ctt caa ggt ttt ggt tct cca caa tat        288
Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr           
                85                  90                  95                

gtg aat acc caa tat cct tgg gat ggt aaa gaa ttc ctt cgt cca cct        336
Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro           
            100                 105                 110                   

caa gtt cct caa gaa tca aat gct gtt gca tca tac gtt aaa cat ttt        384
Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe           
        115                 120                 125                       

acc ttg aat gat gca tta aaa gat aaa aaa gta ttt atc tca ttc caa        432
Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln           
    130                 135                 140                           

ggg gtt gct act tcc atc ttt gta tgg gtc aat ggt aac ttc gta gga        480
Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly           
145                 150                 155                 160           

tac agt gaa gat tca ttt aca cct agt gaa ttt gaa att agt gat tac        528
Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr           
                165                 170                 175               

ctt gtt gaa ggt gat aac aag ttg gcg gta gct gtt tat cgt tac tct        576
Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser           
            180                 185                 190                   

aca gca agc tgg ttg gaa gac caa gac ttc tgg aga ctt tac ggt att        624
Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile           
        195                 200                 205                       

ttt aga gat gtt tac ttg tat gct att cca aaa gtt cac gtt caa gat        672
Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp           
    210                 215                 220                           

ctc ttt gtt aag gga gat tat gat tac caa aca aaa gca ggt caa ttg        720
Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu           
225                 230                 235                 240           

gat att gat ttg aag act gtt ggt gat tat gaa gac aag aag att aaa        768
Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys           
                245                 250                 255               

tat gtt ctt tca gat tat gaa ggc atc gtt aca gaa ggt gat gca tct        816
Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser           
            260                 265                 270                   

gtt aat ggt gac ggt gaa cta tct gta agt ctt gaa aat ctt aaa atc        864
Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile           
        275                 280                 285                       

aaa cct tgg agt gct gaa agt cct aaa ctt tac gat ttg atc ctt cat        912
Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His           
    290                 295                 300                           

gtt ttg gat gat gac caa gtt gtt gaa gtc gtt cca gtt aaa gtt gga        960
Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly           
305                 310                 315                 320           

ttc aga cgc ttt gaa att aaa gat aaa ctt atg ctt ttg aat ggt aag       1008
Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys           
                325                 330                 335               

aga att gtc ttt aaa ggg gtt aac aga cac gaa ttt aac gct aga aca       1056
Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr           
            340                 345                 350                   

gga cgt tgt atc act gaa gaa gat atg ctt tgg gat atc aaa gtg atg       1104
Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met           
        355                 360                 365                       

aag caa cat aac atc aat gct gtt cgt act tca cac tat cct aac caa       1152
Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln           
    370                 375                 380                           

aca cgt tgg tat gaa ttg tgt gat gaa tat gga ctt tat gtt atc gat       1200
Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp           
385                 390                 395                 400           

gaa gcc aac ctt gaa aca cac ggt aca tgg caa aaa ctt ggt cta tgc       1248
Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys           
                405                 410                 415               

gaa cct tca tgg aat atc cca gct agt gaa cca gaa tgg ttg cct gct       1296
Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala           
            420                 425                 430                   

tgt ttg gat cgt gcc aat aac atg ttc caa cgc gat aag aac cac gct       1344
Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala           
        435                 440                 445                       

agt gtt atc att tgg tct tgt ggt aat gaa tca tat gct ggt aaa gat       1392
Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp           
    450                 455                 460                           

att gct gac atg gct gat tac ttc cgt agt gtt gac aat act cgt cca       1440
Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro           
465                 470                 475                 480           

gtt cac tat gaa ggt gtt gca tgg tgt cgt gag ttt gat tac att aca       1488
Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr           
                485                 490                 495               

gac atc gaa agt cgt atg tat gcg aaa cca gct gat atc gaa gaa tac       1536
Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr           
            500                 505                 510                   

ctc aca act ggt aaa cta gtt gat ctt tca agc gtt agt gat aaa cac       1584
Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His           
        515                 520                 525                       

ttt gct tca ggt aac cta act aac aaa cct caa aaa cct tat att tca       1632
Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser           
    530                 535                 540                           

tgt gaa tac atg cac aca atg ggt aac tct ggt ggt gga ttg caa ctc       1680
Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu           
545                 550                 555                 560           

tac act gac tta gag aaa tat cca gaa tac caa ggt gga ttt att tgg       1728
Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp           
                565                 570                 575               

gac ttc att gac caa gct att tac aaa aca ctt cca aat ggt agc gaa       1776
Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu           
            580                 585                 590                   

ttc cta tca tat ggt ggt gac tgg cat gat aga cct tct gac tac gaa       1824
Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu           
        595                 600                 605                       

ttt tgt gga aat ggt atc gtc ttt gca gat cgt acc cta act cca aaa       1872
Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys           
    610                 615                 620                           

ctt caa aca gtt aaa cat ctt tac tct aat att aag att gct gtt gat       1920
Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp           
625                 630                 635                 640           

gaa aaa tca gta act atc aag aat gat aat ctc ttc gaa gat ctt tct       1968
Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser           
                645                 650                 655               

gct tat act ttc cta gct aga gtt tac gaa gat ggt aga aaa gtt agt       2016
Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser           
            660                 665                 670                   

gaa agt gaa tat cac ttt gat gtt aaa cca ggc gaa gaa gca aca ttc       2064
Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe           
        675                 680                 685                       

cca gtt aac ttt gta gtc gag gct tca aat tct gaa caa att tac gaa       2112
Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu           
    690                 695                 700                           

gtt gct tgt gtt ctg agg gaa gca act gaa tgg gct cct aaa ggt cat       2160
Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His           
705                 710                 715                 720           

gaa att gtt cgt ggt caa tat gtt gtt gaa aag att agc act gaa aca       2208
Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr           
                725                 730                 735               

cca gtt aaa gca cct ttg aat gtt gtt gaa ggc gac ttc aac atc ggt       2256
Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly           
            740                 745                 750                   

att caa gga caa aac ttc tca atc ttg ctt tca cgt gca caa aat act       2304
Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr           
        755                 760                 765                       

tta gta tct gct aag tat aat ggt gtt gaa ttc att gag aaa ggt cct       2352
Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro           
    770                 775                 780                           

aaa ctt agc ttc act cgt gct tac act gac aac gat cgt ggt gct gga       2400
Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly           
785                 790                 795                 800           

tat cca ttc gaa atg gca ggc tgg aag gtt gct gga aac tat agt aaa       2448
Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys           
                805                 810                 815               

gtt aca gat act caa att caa atc gaa gac gac tct gtt aaa gtg act       2496
Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr           
            820                 825                 830                   

tat gtt cat gaa ttg cca ggc ttg tct gat gtc gaa gtt aag gta act       2544
Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr           
        835                 840                 845                       

tat caa gtt gat tac aag ggt cga atc ttt gtt act gca aac tat gat       2592
Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp           
    850                 855                 860                           

ggt aaa gca ggt ttg cca aac ttc cct gaa ttt ggt cta gaa ttt gct       2640
Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala           
865                 870                 875                 880           

atc ggt tca caa ttt aca aac ctt agc tat tat gga tac ggt gca gaa       2688
Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu           
                885                 890                 895               

gaa agc tac cgt gat aaa ctt cct ggt gcc tat ctt ggt cga tat gaa       2736
Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu           
            900                 905                 910                   

aca tct gtt gaa aag aca ttt gct cca tat cta atg cca caa gaa tct       2784
Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser           
        915                 920                 925                       

ggt aat cac tat ggt act cgt gaa ttc aca gta tct gat gat aac cat       2832
Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His           
    930                 935                 940                           

aat ggt ctt aaa ttc acc gca ctt aat aaa gca ttc gaa ttc agt gct       2880
Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala           
945                 950                 955                 960           

ttg cgt aac agt act gaa caa att gaa aat gct cgt cac caa tat gag       2928
Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu           
                965                 970                 975               

ttg caa gaa tct gat gct aca tgg att aaa gtt ctt gct gct caa atg       2976
Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met           
            980                 985                 990                   

ggt gta ggt ggt gac gac aca tgg  ggt gct cca gtt cat  gac gaa ttc     3024
Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe         
        995                 1000                 1005                     

ttg ctt  agc tca gca gat agc  tat caa tta agc ttc  atg att gaa        3069
Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu            
    1010                 1015                 1020                        

cca cta  aat tag                                                      3081
Pro Leu  Asn                                                              
    1025                                                                  


<210>  8
<211>  1026
<212>  PRT
<213>  Streptococcus thermophilus strain APC151

<400>  8

Met Asn Met Thr Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Glu Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp Tyr Glu Gly Ile Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Gly Asp Gly Glu Leu Ser Val Ser Leu Glu Asn Leu Lys Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asp Leu Ile Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Ala Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Val Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Asn Leu Thr Asn Lys Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Gln Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Leu Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Ser Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Thr Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Leu  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  9
<211>  3081
<212>  DNA
<213>  Streptococcus infantarius subsp. infantarius CJ18


<220>
<221>  CDS
<222>  (1)..(3081)
<223>  LacZ gene encoding beta-galactosidase

<300>
<308>  GenBank CP003295.1
<309>  2014-01-31
<313>  (956358)..(959438)

<400>  9
gtg aaa aca att gaa aaa att caa act tac tta aac gat cca aag att         48
Val Lys Thr Ile Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile           
1               5                   10                  15                

gtt agc gtt aat aca gtt gac gct cac tca gat cat aag tat ttt gaa         96
Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu           
            20                  25                  30                    

tca ctt gca gaa ttt tct gaa gga gag atg aag tta aga caa tct ctc        144
Ser Leu Ala Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu           
        35                  40                  45                        

aat gga gaa tgg aaa att cac tat gct cag aat aca aat caa gtt tta        192
Asn Gly Glu Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu           
    50                  55                  60                            

aaa gac ttt tat aaa aca gaa ttt gat gaa act gac ttg aat ttc atc        240
Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile           
65                  70                  75                  80            

aat gta cca ggt cat ttg gaa ctt caa ggt ttt ggt tct cca caa tat        288
Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr           
                85                  90                  95                

gtg aat gtc caa tat cct tgg gat ggt aaa gaa ttc ctt cgc cca cct        336
Val Asn Val Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro           
            100                 105                 110                   

caa att cct caa gaa tca aat gct gtt gca tca tac gtt aaa cat ttt        384
Gln Ile Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe           
        115                 120                 125                       

acc ttg aat gat gca tta aaa gat aaa aaa gta ttt atc tca ttc caa        432
Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln           
    130                 135                 140                           

ggg gtt gcc act tcc atc ttt gta tgg gtc aat ggt aac ttc gta gga        480
Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly           
145                 150                 155                 160           

tac agt gaa gat tca ttt aca cct agt gaa ttt gaa att agt gat tac        528
Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr           
                165                 170                 175               

ctt gtt gaa ggt gat aac aag ttg gcg gta gct gtt tat cgt tac tct        576
Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser           
            180                 185                 190                   

aca gca agc tgg ttg gaa gac caa gac ttc tgg aga ctg tac ggt att        624
Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile           
        195                 200                 205                       

ttt aga gat gtt tac ttg tac gct att cca aaa gtt cac gtt caa gat        672
Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp           
    210                 215                 220                           

ctc ttt gtt aag gga gat tat gat tac caa aca aaa gca ggt caa ttg        720
Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu           
225                 230                 235                 240           

gat att gat ttg aag gct gtt ggt gat tac gaa gat aag aaa att aaa        768
Asp Ile Asp Leu Lys Ala Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys           
                245                 250                 255               

tat gtt ctt aca gat cat gaa ggt gtg gtt aca gaa ggt gat gca tct        816
Tyr Val Leu Thr Asp His Glu Gly Val Val Thr Glu Gly Asp Ala Ser           
            260                 265                 270                   

gtt aat gct gac ggt gaa cta tct gta agt ctt gaa gat ttg caa atc        864
Val Asn Ala Asp Gly Glu Leu Ser Val Ser Leu Glu Asp Leu Gln Ile           
        275                 280                 285                       

aaa cct tgg agt gct gaa agt cct aaa ctt tac aat ttg acc ctt cat        912
Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asn Leu Thr Leu His           
    290                 295                 300                           

gtt ttg gat gat gac caa gtt gtt gaa gtt gtt cca gtt aaa gtt gga        960
Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly           
305                 310                 315                 320           

ttt aga cgc ttt gaa att aaa gat aaa ctc atg ctt ttg aat ggt aag       1008
Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys           
                325                 330                 335               

aga att gtc ttt aaa ggg gtt aac aga cac gaa ttt aac gct aga aca       1056
Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr           
            340                 345                 350                   

gga cgt tgt atc act gaa gaa gat atg ctt tgg gat atc aaa gtg atg       1104
Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met           
        355                 360                 365                       

aaa caa cat aac atc aat gct gtt cgt act tct cac tat cct aac caa       1152
Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln           
    370                 375                 380                           

aca cgt tgg tat gaa ttg tgt gat gaa tat gga ctt tat gtt atc gat       1200
Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp           
385                 390                 395                 400           

gaa gcc aac ctt gaa aca cac ggt aca tgg caa aaa ctt aat cta tgc       1248
Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Asn Leu Cys           
                405                 410                 415               

gaa cct tca tgg aat atc cca gct agt gaa cca gaa tgg ttg cct gct       1296
Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala           
            420                 425                 430                   

tgt ttg gat cgt gcc aat aac atg ttc caa cgt gat aag aac cac act       1344
Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Thr           
        435                 440                 445                       

agt gtt atc att tgg tct tgt ggt aat gaa tca tat gct ggt aaa gat       1392
Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp           
    450                 455                 460                           

att gct gac atg gct gat tac ttc cgt agt gtt gac aat act cgt cca       1440
Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro           
465                 470                 475                 480           

gtt cac tat gaa ggt gtt aca tgg tgt cgt gag ttt gat tac att aca       1488
Val His Tyr Glu Gly Val Thr Trp Cys Arg Glu Phe Asp Tyr Ile Thr           
                485                 490                 495               

gac atc gaa agt cgt atg tat gca aaa cca gct gat atc gaa gaa tac       1536
Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr           
            500                 505                 510                   

ctc aca act ggt aaa cta gtt gat ctt tca agc ggt agt gat aaa cac       1584
Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Gly Ser Asp Lys His           
        515                 520                 525                       

ttt gct tca ggt aaa cta act aac agt cct caa aaa cct tat att tca       1632
Phe Ala Ser Gly Lys Leu Thr Asn Ser Pro Gln Lys Pro Tyr Ile Ser           
    530                 535                 540                           

tgt gaa tac atg cac aca atg ggt aac tct ggt ggt gga ttg gaa ctc       1680
Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Glu Leu           
545                 550                 555                 560           

tac act gac tta gag aaa tat cca gaa tac caa ggt gga ttt att tgg       1728
Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp           
                565                 570                 575               

gac ttc att gac caa gct att tac aaa aca ctt cca aat ggt agc gaa       1776
Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu           
            580                 585                 590                   

ttc cta tca tat gga ggt gac tgg cat gat aga cct tct gac tac gaa       1824
Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu           
        595                 600                 605                       

ttt tgt gga aat ggt att gtc ttt gca gat cgt acc cta act cca aaa       1872
Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys           
    610                 615                 620                           

ctt caa aca gtt aaa cat ctt tac tct aat att aag att gct gtt gat       1920
Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp           
625                 630                 635                 640           

gaa aaa tca gta act atc aag aat gat aat gtc ttc gag gat ctt tct       1968
Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Val Phe Glu Asp Leu Ser           
                645                 650                 655               

gct tat act ttc cta gct aga gtt tac gaa gat ggt aga aaa gtt agt       2016
Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser           
            660                 665                 670                   

gaa agt gag tat cac ttt gat gtt aaa cca ggc gaa gaa gca aca ttc       2064
Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe           
        675                 680                 685                       

cca gtt aac ttt gta gtc gag gct tca aat tct gaa caa att tac gaa       2112
Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu           
    690                 695                 700                           

gtt gct tgt gtt ctg agg gaa gca act gaa tgg gct cct aaa ggt cac       2160
Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His           
705                 710                 715                 720           

gaa att gtt cgt ggt caa tat gtt gtt gaa aag att agc act gaa aca       2208
Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr           
                725                 730                 735               

cca gtt aaa gca cct ttg aat gtt gtt gaa ggc gac ttc aac atc ggt       2256
Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly           
            740                 745                 750                   

att caa gga caa aac ttc tca atc ttg ctt tca cgt gca caa aat act       2304
Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr           
        755                 760                 765                       

tta gta tct gct aag tat aat ggt gtt gaa ttc att gag aaa ggt cct       2352
Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro           
    770                 775                 780                           

aaa ctt aac ttc act cgt gct tac act gac aac gat cgt ggt gct gga       2400
Lys Leu Asn Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly           
785                 790                 795                 800           

tat cca ttc gaa atg gca ggc tgg aag gtt gct gga aac tat agt aaa       2448
Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys           
                805                 810                 815               

gtt aca gat act caa att caa atc gaa gac gac tct gtt aaa gtg act       2496
Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr           
            820                 825                 830                   

tat gtt cat gaa ttg cca ggc ttg tct gat gtc gaa gtt aag gta act       2544
Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr           
        835                 840                 845                       

tat caa gtt gac tac aag ggt cga atc ttt gtt act gca aac tat gat       2592
Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp           
    850                 855                 860                           

ggt aaa gca ggt ttg cca aac ttc cct gaa ttt ggt cta gaa ttt gct       2640
Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala           
865                 870                 875                 880           

atc ggt tca caa ttt aca aac ctt agc tat tat gga tac ggt gca gaa       2688
Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu           
                885                 890                 895               

gaa agc tac cgt gat aaa ctt cct ggt gcc tat ctt ggt cga tat gaa       2736
Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu           
            900                 905                 910                   

aca tct gtt gaa aag aca ttt gct cca tat cta atg cca caa gaa tct       2784
Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser           
        915                 920                 925                       

ggc aat cac tat ggt act cgt gaa ttc aca gta tct gat gat aac cat       2832
Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His           
    930                 935                 940                           

aat ggt ctt aaa ttc acc gcc ctt aat aaa gca ttc gaa ttc agt gct       2880
Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala           
945                 950                 955                 960           

ttg cgt aac agt act gaa caa att gaa aat gct cgt cac caa tat gag       2928
Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu           
                965                 970                 975               

ttg caa gaa tct gat gct aca tgg atc aaa gtt ctt gct gct caa atg       2976
Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met           
            980                 985                 990                   

ggt gta ggt ggt gac gac tca tgg  ggt gct cca gtt cat  gat gaa ttc     3024
Gly Val Gly Gly Asp Asp Ser Trp  Gly Ala Pro Val His  Asp Glu Phe         
        995                 1000                 1005                     

ttg gtt  agc tca gca gat agc  tat caa ttg agc ttc  atg att gaa        3069
Leu Val  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu            
    1010                 1015                 1020                        

cca ctc  aac taa                                                      3081
Pro Leu  Asn                                                              
    1025                                                                  


<210>  10
<211>  1026
<212>  PRT
<213>  Streptococcus infantarius subsp. infantarius CJ18

<400>  10

Val Lys Thr Ile Glu Lys Ile Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Ala Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Glu Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Val Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Ile Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Glu Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Ala Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Thr Asp His Glu Gly Val Val Thr Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Ala Asp Gly Glu Leu Ser Val Ser Leu Glu Asp Leu Gln Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asn Leu Thr Leu His 
    290                 295                 300                 


Val Leu Asp Asp Asp Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg Arg Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Asn Leu Cys 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Thr 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Thr Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Thr Gly Lys Leu Val Asp Leu Ser Ser Gly Ser Asp Lys His 
        515                 520                 525             


Phe Ala Ser Gly Lys Leu Thr Asn Ser Pro Gln Lys Pro Tyr Ile Ser 
    530                 535                 540                 


Cys Glu Tyr Met His Thr Met Gly Asn Ser Gly Gly Gly Leu Glu Leu 
545                 550                 555                 560 


Tyr Thr Asp Leu Glu Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp 
                565                 570                 575     


Asp Phe Ile Asp Gln Ala Ile Tyr Lys Thr Leu Pro Asn Gly Ser Glu 
            580                 585                 590         


Phe Leu Ser Tyr Gly Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu 
        595                 600                 605             


Phe Cys Gly Asn Gly Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys 
    610                 615                 620                 


Leu Gln Thr Val Lys His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp 
625                 630                 635                 640 


Glu Lys Ser Val Thr Ile Lys Asn Asp Asn Val Phe Glu Asp Leu Ser 
                645                 650                 655     


Ala Tyr Thr Phe Leu Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser 
            660                 665                 670         


Glu Ser Glu Tyr His Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe 
        675                 680                 685             


Pro Val Asn Phe Val Val Glu Ala Ser Asn Ser Glu Gln Ile Tyr Glu 
    690                 695                 700                 


Val Ala Cys Val Leu Arg Glu Ala Thr Glu Trp Ala Pro Lys Gly His 
705                 710                 715                 720 


Glu Ile Val Arg Gly Gln Tyr Val Val Glu Lys Ile Ser Thr Glu Thr 
                725                 730                 735     


Pro Val Lys Ala Pro Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly 
            740                 745                 750         


Ile Gln Gly Gln Asn Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr 
        755                 760                 765             


Leu Val Ser Ala Lys Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro 
    770                 775                 780                 


Lys Leu Asn Phe Thr Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly 
785                 790                 795                 800 


Tyr Pro Phe Glu Met Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys 
                805                 810                 815     


Val Thr Asp Thr Gln Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr 
            820                 825                 830         


Tyr Val His Glu Leu Pro Gly Leu Ser Asp Val Glu Val Lys Val Thr 
        835                 840                 845             


Tyr Gln Val Asp Tyr Lys Gly Arg Ile Phe Val Thr Ala Asn Tyr Asp 
    850                 855                 860                 


Gly Lys Ala Gly Leu Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala 
865                 870                 875                 880 


Ile Gly Ser Gln Phe Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu 
                885                 890                 895     


Glu Ser Tyr Arg Asp Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu 
            900                 905                 910         


Thr Ser Val Glu Lys Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser 
        915                 920                 925             


Gly Asn His Tyr Gly Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His 
    930                 935                 940                 


Asn Gly Leu Lys Phe Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala 
945                 950                 955                 960 


Leu Arg Asn Ser Thr Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu 
                965                 970                 975     


Leu Gln Glu Ser Asp Ala Thr Trp Ile Lys Val Leu Ala Ala Gln Met 
            980                 985                 990         


Gly Val Gly Gly Asp Asp Ser Trp  Gly Ala Pro Val His  Asp Glu Phe 
        995                 1000                 1005             


Leu Val  Ser Ser Ala Asp Ser  Tyr Gln Leu Ser Phe  Met Ile Glu 
    1010                 1015                 1020             


Pro Leu  Asn 
    1025     


<210>  11
<211>  3018
<212>  DNA
<213>  Streptococcus salivarius CCHSS3


<220>
<221>  CDS
<222>  (1)..(3018)
<223>  LacZ gene endocing beta-galactosidase

<300>
<308>  GenBank FR873481.1
<309>  2015-02-27
<313>  (809610)..(812627)

<400>  11
atg aaa aca act gaa aaa ctt caa act tac tta aac gat cca aag att         48
Met Lys Thr Thr Glu Lys Leu Gln Thr Tyr Leu Asn Asp Pro Lys Ile           
1               5                   10                  15                

gtt agc gtt aat aca gtt gac gct cac tca gat cat aag tat ttt gaa         96
Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu           
            20                  25                  30                    

tca ctt aca gaa ttt tct gaa gga gag atg aag tta aga caa tct ctt        144
Ser Leu Thr Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu           
        35                  40                  45                        

aat gga aaa tgg aaa att cac tat gct cag aat aca aat cag gtt tta        192
Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu           
    50                  55                  60                            

aaa gac ttt tat aaa aca gaa ttt gat gaa act gat ttg aat ttc atc        240
Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile           
65                  70                  75                  80            

aat gta cca ggt cat ttg gaa ctt caa ggt ttt ggt tct cca caa tat        288
Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr           
                85                  90                  95                

gtg aat acc caa tat cct tgg gat ggt aaa gaa ttc ctt cgt cca cct        336
Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro           
            100                 105                 110                   

caa gtt cct caa gaa tca aat gct gtt gca tca tac gtt aaa cat ttt        384
Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe           
        115                 120                 125                       

acc ttg aat gat gca tta aaa gac aaa aaa gta ttt atc tca ttc caa        432
Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln           
    130                 135                 140                           

ggg gtt gcc act tcc atc ttt gta tgg gtc aat ggt aac ttc gta gga        480
Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly           
145                 150                 155                 160           

tac agt gaa gat tca ttt aca cct agt gaa ttt gaa att agt gat tac        528
Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr           
                165                 170                 175               

ctt gtt gga ggt gat aac aag ttg gcg gta gct gtt tat cgt tac tct        576
Leu Val Gly Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser           
            180                 185                 190                   

aca gca agc tgg ttg gaa gac caa gac ttc tgg aga ctt tac ggt att        624
Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile           
        195                 200                 205                       

ttc aga gat gtt tac ttg tac gct att cca aaa gtt cac gtt caa gat        672
Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp           
    210                 215                 220                           

ctc ttt gtt aag gga gat tat gat tac caa aca aaa gca ggt caa ttg        720
Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu           
225                 230                 235                 240           

gat att gat ttg aag act gtt ggt gat tac gaa gat aag aaa att aaa        768
Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys           
                245                 250                 255               

tat gtt ctt tca gat cat gaa ggc atc gtt aaa gaa ggt gat gca tct        816
Tyr Val Leu Ser Asp His Glu Gly Ile Val Lys Glu Gly Asp Ala Ser           
            260                 265                 270                   

gtt aat gct gac ggt gaa cta tct gta agt ctt gaa gat ttg caa atc        864
Val Asn Ala Asp Gly Glu Leu Ser Val Ser Leu Glu Asp Leu Gln Ile           
        275                 280                 285                       

aaa cct tgg agt gct gaa agt cct aaa ctt tac aat ttg acc ctt cat        912
Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asn Leu Thr Leu His           
    290                 295                 300                           

gtt ttg gat gat ggc caa gtt gtt gaa gtc gtt cca gtt aag gtt gga        960
Val Leu Asp Asp Gly Gln Val Val Glu Val Val Pro Val Lys Val Gly           
305                 310                 315                 320           

ttt aga cac ttc gaa att aaa gat aaa ctc atg ctt ttg aat ggt aag       1008
Phe Arg His Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys           
                325                 330                 335               

aga att gtc ttt aaa ggg gtt aac aga cac gaa ttt aac gct aga aca       1056
Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr           
            340                 345                 350                   

gga cgt tgt atc act gaa gaa gat atg ctt tgg gat atc aaa gtg atg       1104
Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met           
        355                 360                 365                       

aaa caa cat aac atc aat gct gtt cgt act tct cac tat cct aac caa       1152
Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln           
    370                 375                 380                           

aca cgt tgg tat gaa ttg tgt gat gaa tat gga ctt tat gtt atc gat       1200
Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp           
385                 390                 395                 400           

gaa gcc aac ctt gaa aca cac ggt aca tgg caa aaa ctt ggt cta agc       1248
Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Ser           
                405                 410                 415               

gaa cct tca tgg aat atc cca gct agt gaa cca gaa tgg ttg cct gct       1296
Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala           
            420                 425                 430                   

tgt ttg gat cgt gcc aat aac atg ttc caa cgt gat aag aac cat gct       1344
Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala           
        435                 440                 445                       

agt gtt atc att tgg tct tgt ggt aat gaa tca tat gct ggt aaa gat       1392
Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp           
    450                 455                 460                           

att gct gac atg gct gat tac ttc cgt agt gtt gac aat act cgt cca       1440
Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro           
465                 470                 475                 480           

gtt cac tat gaa ggt gtt aca tgg tgt cgt gaa ttt gat tac att aca       1488
Val His Tyr Glu Gly Val Thr Trp Cys Arg Glu Phe Asp Tyr Ile Thr           
                485                 490                 495               

gac atc gaa agt cgt atg tat gcg aaa cca gct gat att gaa gaa tac       1536
Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr           
            500                 505                 510                   

ctc act aac aat cct caa aaa cct tat att tca tgt gaa tac atg cac       1584
Leu Thr Asn Asn Pro Gln Lys Pro Tyr Ile Ser Cys Glu Tyr Met His           
        515                 520                 525                       

aca atg ggt aac tct ggt ggt gga ttg aaa ctc tac act gac tta gag       1632
Thr Met Gly Asn Ser Gly Gly Gly Leu Lys Leu Tyr Thr Asp Leu Glu           
    530                 535                 540                           

aaa tat cca gaa tac caa ggt gga ttt att tgg gac ttc att gac caa       1680
Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp Asp Phe Ile Asp Gln           
545                 550                 555                 560           

gct att tac aaa cca ctt cca aat ggt agc gaa ttc cta tca tat ggt       1728
Ala Ile Tyr Lys Pro Leu Pro Asn Gly Ser Glu Phe Leu Ser Tyr Gly           
                565                 570                 575               

ggt gac tgg cat gat aga cct tct gac tac gaa ttt tgt gga aat ggt       1776
Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu Phe Cys Gly Asn Gly           
            580                 585                 590                   

att gtc ttc gca gat cgt acc cta act cca aaa ctt caa aca gtt aaa       1824
Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys Leu Gln Thr Val Lys           
        595                 600                 605                       

cat ctt tac tct aat att aag att gct gtt gat gaa aaa tca gta act       1872
His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp Glu Lys Ser Val Thr           
    610                 615                 620                           

atc aag aat gat aat gtc ttt gaa gat ctt tct gct tat act ttc cta       1920
Ile Lys Asn Asp Asn Val Phe Glu Asp Leu Ser Ala Tyr Thr Phe Leu           
625                 630                 635                 640           

gct aga gtt tac gaa gat ggt aga aaa gtt agc gaa agt gaa tat cac       1968
Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser Glu Ser Glu Tyr His           
                645                 650                 655               

ttt gat gtt aaa cca ggt gaa gaa gca aca ttc cca gta gaa ttc gct       2016
Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe Pro Val Glu Phe Ala           
            660                 665                 670                   

gtt gga gct tca aat gct gaa cga att tat gaa gtt gct tgt gtt cag       2064
Val Gly Ala Ser Asn Ala Glu Arg Ile Tyr Glu Val Ala Cys Val Gln           
        675                 680                 685                       

aat gaa gca act gaa tgg gct cca aaa gga cat gaa att gtt cgt ggt       2112
Asn Glu Ala Thr Glu Trp Ala Pro Lys Gly His Glu Ile Val Arg Gly           
    690                 695                 700                           

caa tat gtt gct gaa aag att agc act gaa aca cca gtt aaa gca cct       2160
Gln Tyr Val Ala Glu Lys Ile Ser Thr Glu Thr Pro Val Lys Ala Pro           
705                 710                 715                 720           

ttg aat gtt gtt gaa ggc gac ttc aac atc gga att caa gga caa aac       2208
Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly Ile Gln Gly Gln Asn           
                725                 730                 735               

ttc tct atc ttg ctt tca cgt gca caa aat acg cta gta tct gct aag       2256
Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr Leu Val Ser Ala Lys           
            740                 745                 750                   

tat aac ggt gtt gaa ttc att gag aaa ggt cct aaa ctt aac ttt act       2304
Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro Lys Leu Asn Phe Thr           
        755                 760                 765                       

cgt gct tac acc gac aac gat cgt ggt gct gga tat cca ttc gaa atg       2352
Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly Tyr Pro Phe Glu Met           
    770                 775                 780                           

gca ggc tgg aaa gtt gct gga aac tat agt aag gtt aca gat act caa       2400
Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys Val Thr Asp Thr Gln           
785                 790                 795                 800           

att caa att gaa gat gac tct gtt aaa gtg act tat gtt cat gaa ttg       2448
Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr Tyr Val His Glu Leu           
                805                 810                 815               

cct ggt ttt tct gat gtc gaa gtt aag gta act tat caa gtt gat tac       2496
Pro Gly Phe Ser Asp Val Glu Val Lys Val Thr Tyr Gln Val Asp Tyr           
            820                 825                 830                   

aag ggt cga atc ttt gtt act aca agc tat gat ggt aaa gca ggt ttg       2544
Lys Gly Arg Ile Phe Val Thr Thr Ser Tyr Asp Gly Lys Ala Gly Leu           
        835                 840                 845                       

cca aac ttc cct gaa ttt ggt cta gaa ttt gct atc ggt tca caa ttt       2592
Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala Ile Gly Ser Gln Phe           
    850                 855                 860                           

aca aac cta agc tat tat gga tac ggt gca gaa gaa agc tac ctt gat       2640
Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu Glu Ser Tyr Leu Asp           
865                 870                 875                 880           

aaa ctt cct ggt gcc tat ctt ggt cga tat gaa aca tct gtt gaa aag       2688
Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu Thr Ser Val Glu Lys           
                885                 890                 895               

aca ttt gct cca tat cta atg cca caa gaa tct ggt aat cac tat ggt       2736
Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser Gly Asn His Tyr Gly           
            900                 905                 910                   

act cgt gaa ttt aca gta tct gat gat aac cat aat ggt ctt aaa ttc       2784
Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His Asn Gly Leu Lys Phe           
        915                 920                 925                       

acc gca cta aat aag gca ttc gaa ttc agt gct ttg ctt aac agt act       2832
Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala Leu Leu Asn Ser Thr           
    930                 935                 940                           

gaa caa att gaa aat gct cgt cat caa tat gaa ttg caa caa tct gat       2880
Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu Leu Gln Gln Ser Asp           
945                 950                 955                 960           

gct aca tgg att aaa gtt ctt gct gtt caa atg ggt gtc ggt ggt gac       2928
Ala Thr Trp Ile Lys Val Leu Ala Val Gln Met Gly Val Gly Gly Asp           
                965                 970                 975               

gac tca tgg ggt gct cca gtt cat gac gaa ttc ttg gtt agc tca gca       2976
Asp Ser Trp Gly Ala Pro Val His Asp Glu Phe Leu Val Ser Ser Ala           
            980                 985                 990                   

gat agc tat caa ttg agc ttc gtg  att gaa cca ctc aac  taa             3018
Asp Ser Tyr Gln Leu Ser Phe Val  Ile Glu Pro Leu Asn                      
        995                 1000                 1005                     


<210>  12
<211>  1005
<212>  PRT
<213>  Streptococcus salivarius CCHSS3

<400>  12

Met Lys Thr Thr Glu Lys Leu Gln Thr Tyr Leu Asn Asp Pro Lys Ile 
1               5                   10                  15      


Val Ser Val Asn Thr Val Asp Ala His Ser Asp His Lys Tyr Phe Glu 
            20                  25                  30          


Ser Leu Thr Glu Phe Ser Glu Gly Glu Met Lys Leu Arg Gln Ser Leu 
        35                  40                  45              


Asn Gly Lys Trp Lys Ile His Tyr Ala Gln Asn Thr Asn Gln Val Leu 
    50                  55                  60                  


Lys Asp Phe Tyr Lys Thr Glu Phe Asp Glu Thr Asp Leu Asn Phe Ile 
65                  70                  75                  80  


Asn Val Pro Gly His Leu Glu Leu Gln Gly Phe Gly Ser Pro Gln Tyr 
                85                  90                  95      


Val Asn Thr Gln Tyr Pro Trp Asp Gly Lys Glu Phe Leu Arg Pro Pro 
            100                 105                 110         


Gln Val Pro Gln Glu Ser Asn Ala Val Ala Ser Tyr Val Lys His Phe 
        115                 120                 125             


Thr Leu Asn Asp Ala Leu Lys Asp Lys Lys Val Phe Ile Ser Phe Gln 
    130                 135                 140                 


Gly Val Ala Thr Ser Ile Phe Val Trp Val Asn Gly Asn Phe Val Gly 
145                 150                 155                 160 


Tyr Ser Glu Asp Ser Phe Thr Pro Ser Glu Phe Glu Ile Ser Asp Tyr 
                165                 170                 175     


Leu Val Gly Gly Asp Asn Lys Leu Ala Val Ala Val Tyr Arg Tyr Ser 
            180                 185                 190         


Thr Ala Ser Trp Leu Glu Asp Gln Asp Phe Trp Arg Leu Tyr Gly Ile 
        195                 200                 205             


Phe Arg Asp Val Tyr Leu Tyr Ala Ile Pro Lys Val His Val Gln Asp 
    210                 215                 220                 


Leu Phe Val Lys Gly Asp Tyr Asp Tyr Gln Thr Lys Ala Gly Gln Leu 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Thr Val Gly Asp Tyr Glu Asp Lys Lys Ile Lys 
                245                 250                 255     


Tyr Val Leu Ser Asp His Glu Gly Ile Val Lys Glu Gly Asp Ala Ser 
            260                 265                 270         


Val Asn Ala Asp Gly Glu Leu Ser Val Ser Leu Glu Asp Leu Gln Ile 
        275                 280                 285             


Lys Pro Trp Ser Ala Glu Ser Pro Lys Leu Tyr Asn Leu Thr Leu His 
    290                 295                 300                 


Val Leu Asp Asp Gly Gln Val Val Glu Val Val Pro Val Lys Val Gly 
305                 310                 315                 320 


Phe Arg His Phe Glu Ile Lys Asp Lys Leu Met Leu Leu Asn Gly Lys 
                325                 330                 335     


Arg Ile Val Phe Lys Gly Val Asn Arg His Glu Phe Asn Ala Arg Thr 
            340                 345                 350         


Gly Arg Cys Ile Thr Glu Glu Asp Met Leu Trp Asp Ile Lys Val Met 
        355                 360                 365             


Lys Gln His Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro Asn Gln 
    370                 375                 380                 


Thr Arg Trp Tyr Glu Leu Cys Asp Glu Tyr Gly Leu Tyr Val Ile Asp 
385                 390                 395                 400 


Glu Ala Asn Leu Glu Thr His Gly Thr Trp Gln Lys Leu Gly Leu Ser 
                405                 410                 415     


Glu Pro Ser Trp Asn Ile Pro Ala Ser Glu Pro Glu Trp Leu Pro Ala 
            420                 425                 430         


Cys Leu Asp Arg Ala Asn Asn Met Phe Gln Arg Asp Lys Asn His Ala 
        435                 440                 445             


Ser Val Ile Ile Trp Ser Cys Gly Asn Glu Ser Tyr Ala Gly Lys Asp 
    450                 455                 460                 


Ile Ala Asp Met Ala Asp Tyr Phe Arg Ser Val Asp Asn Thr Arg Pro 
465                 470                 475                 480 


Val His Tyr Glu Gly Val Thr Trp Cys Arg Glu Phe Asp Tyr Ile Thr 
                485                 490                 495     


Asp Ile Glu Ser Arg Met Tyr Ala Lys Pro Ala Asp Ile Glu Glu Tyr 
            500                 505                 510         


Leu Thr Asn Asn Pro Gln Lys Pro Tyr Ile Ser Cys Glu Tyr Met His 
        515                 520                 525             


Thr Met Gly Asn Ser Gly Gly Gly Leu Lys Leu Tyr Thr Asp Leu Glu 
    530                 535                 540                 


Lys Tyr Pro Glu Tyr Gln Gly Gly Phe Ile Trp Asp Phe Ile Asp Gln 
545                 550                 555                 560 


Ala Ile Tyr Lys Pro Leu Pro Asn Gly Ser Glu Phe Leu Ser Tyr Gly 
                565                 570                 575     


Gly Asp Trp His Asp Arg Pro Ser Asp Tyr Glu Phe Cys Gly Asn Gly 
            580                 585                 590         


Ile Val Phe Ala Asp Arg Thr Leu Thr Pro Lys Leu Gln Thr Val Lys 
        595                 600                 605             


His Leu Tyr Ser Asn Ile Lys Ile Ala Val Asp Glu Lys Ser Val Thr 
    610                 615                 620                 


Ile Lys Asn Asp Asn Val Phe Glu Asp Leu Ser Ala Tyr Thr Phe Leu 
625                 630                 635                 640 


Ala Arg Val Tyr Glu Asp Gly Arg Lys Val Ser Glu Ser Glu Tyr His 
                645                 650                 655     


Phe Asp Val Lys Pro Gly Glu Glu Ala Thr Phe Pro Val Glu Phe Ala 
            660                 665                 670         


Val Gly Ala Ser Asn Ala Glu Arg Ile Tyr Glu Val Ala Cys Val Gln 
        675                 680                 685             


Asn Glu Ala Thr Glu Trp Ala Pro Lys Gly His Glu Ile Val Arg Gly 
    690                 695                 700                 


Gln Tyr Val Ala Glu Lys Ile Ser Thr Glu Thr Pro Val Lys Ala Pro 
705                 710                 715                 720 


Leu Asn Val Val Glu Gly Asp Phe Asn Ile Gly Ile Gln Gly Gln Asn 
                725                 730                 735     


Phe Ser Ile Leu Leu Ser Arg Ala Gln Asn Thr Leu Val Ser Ala Lys 
            740                 745                 750         


Tyr Asn Gly Val Glu Phe Ile Glu Lys Gly Pro Lys Leu Asn Phe Thr 
        755                 760                 765             


Arg Ala Tyr Thr Asp Asn Asp Arg Gly Ala Gly Tyr Pro Phe Glu Met 
    770                 775                 780                 


Ala Gly Trp Lys Val Ala Gly Asn Tyr Ser Lys Val Thr Asp Thr Gln 
785                 790                 795                 800 


Ile Gln Ile Glu Asp Asp Ser Val Lys Val Thr Tyr Val His Glu Leu 
                805                 810                 815     


Pro Gly Phe Ser Asp Val Glu Val Lys Val Thr Tyr Gln Val Asp Tyr 
            820                 825                 830         


Lys Gly Arg Ile Phe Val Thr Thr Ser Tyr Asp Gly Lys Ala Gly Leu 
        835                 840                 845             


Pro Asn Phe Pro Glu Phe Gly Leu Glu Phe Ala Ile Gly Ser Gln Phe 
    850                 855                 860                 


Thr Asn Leu Ser Tyr Tyr Gly Tyr Gly Ala Glu Glu Ser Tyr Leu Asp 
865                 870                 875                 880 


Lys Leu Pro Gly Ala Tyr Leu Gly Arg Tyr Glu Thr Ser Val Glu Lys 
                885                 890                 895     


Thr Phe Ala Pro Tyr Leu Met Pro Gln Glu Ser Gly Asn His Tyr Gly 
            900                 905                 910         


Thr Arg Glu Phe Thr Val Ser Asp Asp Asn His Asn Gly Leu Lys Phe 
        915                 920                 925             


Thr Ala Leu Asn Lys Ala Phe Glu Phe Ser Ala Leu Leu Asn Ser Thr 
    930                 935                 940                 


Glu Gln Ile Glu Asn Ala Arg His Gln Tyr Glu Leu Gln Gln Ser Asp 
945                 950                 955                 960 


Ala Thr Trp Ile Lys Val Leu Ala Val Gln Met Gly Val Gly Gly Asp 
                965                 970                 975     


Asp Ser Trp Gly Ala Pro Val His Asp Glu Phe Leu Val Ser Ser Ala 
            980                 985                 990         


Asp Ser Tyr Gln Leu Ser Phe Val  Ile Glu Pro Leu Asn  
        995                 1000                 1005 


<210>  13
<211>  945
<212>  DNA
<213>  Corynebacterium glutamicum strain ATCC 13032


<220>
<221>  CDS
<222>  (1)..(945)
<223>  ldh gene encoding L-lactate dehydrogenase

<300>
<308>  GenBank CP025533.1
<309>  2017-12-27
<313>  (3119670)..(3120614)

<400>  13
atg aaa gaa acc gtc ggt aac aag att gtc ctc att ggc gca gga gat         48
Met Lys Glu Thr Val Gly Asn Lys Ile Val Leu Ile Gly Ala Gly Asp           
1               5                   10                  15                

gtt gga gtt gca tac gca tac gca ctg atc aac cag ggc atg gca gat         96
Val Gly Val Ala Tyr Ala Tyr Ala Leu Ile Asn Gln Gly Met Ala Asp           
            20                  25                  30                    

cac ctt gcg atc atc gac atc gat gaa aag aaa ctc gaa ggc aac gtc        144
His Leu Ala Ile Ile Asp Ile Asp Glu Lys Lys Leu Glu Gly Asn Val           
        35                  40                  45                        

atg gac tta aac cat ggt gtt gtg tgg gcc gat tcc cgc acc cgc gtc        192
Met Asp Leu Asn His Gly Val Val Trp Ala Asp Ser Arg Thr Arg Val           
    50                  55                  60                            

acc aag ggc acc tac gct gac tgc gaa gac gca gcc atg gtt gtc att        240
Thr Lys Gly Thr Tyr Ala Asp Cys Glu Asp Ala Ala Met Val Val Ile           
65                  70                  75                  80            

tgt gcc ggc gca gcc caa aag cca ggc gag acc cgc ctc cag ctg gtg        288
Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Gln Leu Val           
                85                  90                  95                

gac aaa aac gtc aag att atg aaa tcc atc gtc ggc gat gtc atg gac        336
Asp Lys Asn Val Lys Ile Met Lys Ser Ile Val Gly Asp Val Met Asp           
            100                 105                 110                   

agc gga ttc gac ggc atc ttc ctc gtg gcg tcc aac cca gtg gat atc        384
Ser Gly Phe Asp Gly Ile Phe Leu Val Ala Ser Asn Pro Val Asp Ile           
        115                 120                 125                       

ctg acc tac gca gtg tgg aaa ttc tcc ggc ttg gaa tgg aac cgc gtg        432
Leu Thr Tyr Ala Val Trp Lys Phe Ser Gly Leu Glu Trp Asn Arg Val           
    130                 135                 140                           

atc ggc tcc gga act gtc ctg gac tcc gct cga ttc cgc tac atg ctg        480
Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu           
145                 150                 155                 160           

ggc gaa ctc tac gaa gtg gca cca agc tcc gtc cac gcc tac atc atc        528
Gly Glu Leu Tyr Glu Val Ala Pro Ser Ser Val His Ala Tyr Ile Ile           
                165                 170                 175               

ggc gaa cac ggc gac act gaa ctt cca gtc ctg tcc tcc gcg acc atc        576
Gly Glu His Gly Asp Thr Glu Leu Pro Val Leu Ser Ser Ala Thr Ile           
            180                 185                 190                   

gca ggc gta tcg ctt agc cga atg ctg gac aaa gac cca gag ctt gag        624
Ala Gly Val Ser Leu Ser Arg Met Leu Asp Lys Asp Pro Glu Leu Glu           
        195                 200                 205                       

ggc cgt cta gag aaa att ttc gaa gac acc cgc gac gct gcc tat cac        672
Gly Arg Leu Glu Lys Ile Phe Glu Asp Thr Arg Asp Ala Ala Tyr His           
    210                 215                 220                           

att atc gac gcc aag ggc tcc act tcc tac ggc atc ggc atg ggt ctt        720
Ile Ile Asp Ala Lys Gly Ser Thr Ser Tyr Gly Ile Gly Met Gly Leu           
225                 230                 235                 240           

gct cgc atc acc cgc gca atc ctg cag aac caa gac gtt gca gtc cca        768
Ala Arg Ile Thr Arg Ala Ile Leu Gln Asn Gln Asp Val Ala Val Pro           
                245                 250                 255               

gtc tct gca ctg ctc cac ggt gaa tac ggt gag gaa gac atc tac atc        816
Val Ser Ala Leu Leu His Gly Glu Tyr Gly Glu Glu Asp Ile Tyr Ile           
            260                 265                 270                   

ggc acc cca gct gtg gtg aac cgc cga ggc atc cgc cgc gtt gtc gaa        864
Gly Thr Pro Ala Val Val Asn Arg Arg Gly Ile Arg Arg Val Val Glu           
        275                 280                 285                       

cta gaa atc acc gac cac gag atg gaa cgc ttc aag cat tcc gca aat        912
Leu Glu Ile Thr Asp His Glu Met Glu Arg Phe Lys His Ser Ala Asn           
    290                 295                 300                           

acc ctg cgc gaa att cag aag cag ttc ttc taa                            945
Thr Leu Arg Glu Ile Gln Lys Gln Phe Phe                                   
305                 310                                                   


<210>  14
<211>  314
<212>  PRT
<213>  Corynebacterium glutamicum strain ATCC 13032

<400>  14

Met Lys Glu Thr Val Gly Asn Lys Ile Val Leu Ile Gly Ala Gly Asp 
1               5                   10                  15      


Val Gly Val Ala Tyr Ala Tyr Ala Leu Ile Asn Gln Gly Met Ala Asp 
            20                  25                  30          


His Leu Ala Ile Ile Asp Ile Asp Glu Lys Lys Leu Glu Gly Asn Val 
        35                  40                  45              


Met Asp Leu Asn His Gly Val Val Trp Ala Asp Ser Arg Thr Arg Val 
    50                  55                  60                  


Thr Lys Gly Thr Tyr Ala Asp Cys Glu Asp Ala Ala Met Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Gln Leu Val 
                85                  90                  95      


Asp Lys Asn Val Lys Ile Met Lys Ser Ile Val Gly Asp Val Met Asp 
            100                 105                 110         


Ser Gly Phe Asp Gly Ile Phe Leu Val Ala Ser Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Val Trp Lys Phe Ser Gly Leu Glu Trp Asn Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu 
145                 150                 155                 160 


Gly Glu Leu Tyr Glu Val Ala Pro Ser Ser Val His Ala Tyr Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Pro Val Leu Ser Ser Ala Thr Ile 
            180                 185                 190         


Ala Gly Val Ser Leu Ser Arg Met Leu Asp Lys Asp Pro Glu Leu Glu 
        195                 200                 205             


Gly Arg Leu Glu Lys Ile Phe Glu Asp Thr Arg Asp Ala Ala Tyr His 
    210                 215                 220                 


Ile Ile Asp Ala Lys Gly Ser Thr Ser Tyr Gly Ile Gly Met Gly Leu 
225                 230                 235                 240 


Ala Arg Ile Thr Arg Ala Ile Leu Gln Asn Gln Asp Val Ala Val Pro 
                245                 250                 255     


Val Ser Ala Leu Leu His Gly Glu Tyr Gly Glu Glu Asp Ile Tyr Ile 
            260                 265                 270         


Gly Thr Pro Ala Val Val Asn Arg Arg Gly Ile Arg Arg Val Val Glu 
        275                 280                 285             


Leu Glu Ile Thr Asp His Glu Met Glu Arg Phe Lys His Ser Ala Asn 
    290                 295                 300                 


Thr Leu Arg Glu Ile Gln Lys Gln Phe Phe 
305                 310                 


<210>  15
<211>  948
<212>  DNA
<213>  Corynebacterium callunae DSM 20147


<220>
<221>  CDS
<222>  (1)..(948)
<223>  ldh gene encoding L-lactate-dehydrogenase

<300>
<308>  GenBank CP004354.1
<309>  2015-01-16
<313>  (2672590)..(2673537)

<400>  15
atg aaa aag acc gtc gga aat aag atc gtt ctc att ggt gca ggt gat         48
Met Lys Lys Thr Val Gly Asn Lys Ile Val Leu Ile Gly Ala Gly Asp           
1               5                   10                  15                

gtc gga gtt gct tat gct tat gcg ctg att aac caa gga acc tgc gat         96
Val Gly Val Ala Tyr Ala Tyr Ala Leu Ile Asn Gln Gly Thr Cys Asp           
            20                  25                  30                    

cac cta gcc atc att gac att gat gaa aag aag ctc gaa ggc aat gtc        144
His Leu Ala Ile Ile Asp Ile Asp Glu Lys Lys Leu Glu Gly Asn Val           
        35                  40                  45                        

atg gac cta aac cac ggt gtg gtg tgg tcg gaa tcc cgt act cgc gta        192
Met Asp Leu Asn His Gly Val Val Trp Ser Glu Ser Arg Thr Arg Val           
    50                  55                  60                            

acc aag gga acc tac gca gac tgc gaa gac gct gcc atg gtg gtt att        240
Thr Lys Gly Thr Tyr Ala Asp Cys Glu Asp Ala Ala Met Val Val Ile           
65                  70                  75                  80            

tgc gca ggt gca gcc caa agg cca ggc gaa act cgc ctg cag ctg gtg        288
Cys Ala Gly Ala Ala Gln Arg Pro Gly Glu Thr Arg Leu Gln Leu Val           
                85                  90                  95                

gat aaa aac gtc aag atc atg aag tct att gtt ggc gag gtc atg gcc        336
Asp Lys Asn Val Lys Ile Met Lys Ser Ile Val Gly Glu Val Met Ala           
            100                 105                 110                   

gcc ggc ttt gat gga att ttc ctg gta gcc agc aac ccc gta gac atc        384
Ala Gly Phe Asp Gly Ile Phe Leu Val Ala Ser Asn Pro Val Asp Ile           
        115                 120                 125                       

ctc act tat gca gta tgg aag ttc tcc ggc ttg gac tgg cac cgc gta        432
Leu Thr Tyr Ala Val Trp Lys Phe Ser Gly Leu Asp Trp His Arg Val           
    130                 135                 140                           

atc ggc tcg ggc acc gtc ttg gac tcc gca cgt ttc cgc tat atg ctg        480
Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu           
145                 150                 155                 160           

ggc gag ctt tat gag gta gcg cca agc tcc att cac tcc tac att att        528
Gly Glu Leu Tyr Glu Val Ala Pro Ser Ser Ile His Ser Tyr Ile Ile           
                165                 170                 175               

ggc gag cat ggc gat acc gaa ctc cca gtg ctt tct tcc gcc acc atc        576
Gly Glu His Gly Asp Thr Glu Leu Pro Val Leu Ser Ser Ala Thr Ile           
            180                 185                 190                   

gcc ggt gtt tcc ctg cgc aag ctt ttg gaa aag gat cca gag cta gat        624
Ala Gly Val Ser Leu Arg Lys Leu Leu Glu Lys Asp Pro Glu Leu Asp           
        195                 200                 205                       

ggc cgc ttg gaa aaa gtc ttt gaa gat act cgc gac gct gcc tat cac        672
Gly Arg Leu Glu Lys Val Phe Glu Asp Thr Arg Asp Ala Ala Tyr His           
    210                 215                 220                           

atc atc gat gcc aag ggc tca acc tct tat ggc att ggc atg ggc ttg        720
Ile Ile Asp Ala Lys Gly Ser Thr Ser Tyr Gly Ile Gly Met Gly Leu           
225                 230                 235                 240           

gcg cgt atc acc cgc gcg gtt atc caa aac caa gac gtg gcg ctt ccc        768
Ala Arg Ile Thr Arg Ala Val Ile Gln Asn Gln Asp Val Ala Leu Pro           
                245                 250                 255               

gta tct gcg ctg ctc aat ggc gaa tat ggg gaa gaa gac att tat att        816
Val Ser Ala Leu Leu Asn Gly Glu Tyr Gly Glu Glu Asp Ile Tyr Ile           
            260                 265                 270                   

ggt acc ccg gcc atc att aac cgc cgt ggt att cgc cgc gtg gta gaa        864
Gly Thr Pro Ala Ile Ile Asn Arg Arg Gly Ile Arg Arg Val Val Glu           
        275                 280                 285                       

ctg gaa atc agc gag cat gag atg gag cgc ttc aag cac tcc gct aat        912
Leu Glu Ile Ser Glu His Glu Met Glu Arg Phe Lys His Ser Ala Asn           
    290                 295                 300                           

act ttg cgt gct att cag gaa cag att ttc agc taa                        948
Thr Leu Arg Ala Ile Gln Glu Gln Ile Phe Ser                               
305                 310                 315                               


<210>  16
<211>  315
<212>  PRT
<213>  Corynebacterium callunae DSM 20147

<400>  16

Met Lys Lys Thr Val Gly Asn Lys Ile Val Leu Ile Gly Ala Gly Asp 
1               5                   10                  15      


Val Gly Val Ala Tyr Ala Tyr Ala Leu Ile Asn Gln Gly Thr Cys Asp 
            20                  25                  30          


His Leu Ala Ile Ile Asp Ile Asp Glu Lys Lys Leu Glu Gly Asn Val 
        35                  40                  45              


Met Asp Leu Asn His Gly Val Val Trp Ser Glu Ser Arg Thr Arg Val 
    50                  55                  60                  


Thr Lys Gly Thr Tyr Ala Asp Cys Glu Asp Ala Ala Met Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Arg Pro Gly Glu Thr Arg Leu Gln Leu Val 
                85                  90                  95      


Asp Lys Asn Val Lys Ile Met Lys Ser Ile Val Gly Glu Val Met Ala 
            100                 105                 110         


Ala Gly Phe Asp Gly Ile Phe Leu Val Ala Ser Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Val Trp Lys Phe Ser Gly Leu Asp Trp His Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu 
145                 150                 155                 160 


Gly Glu Leu Tyr Glu Val Ala Pro Ser Ser Ile His Ser Tyr Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Pro Val Leu Ser Ser Ala Thr Ile 
            180                 185                 190         


Ala Gly Val Ser Leu Arg Lys Leu Leu Glu Lys Asp Pro Glu Leu Asp 
        195                 200                 205             


Gly Arg Leu Glu Lys Val Phe Glu Asp Thr Arg Asp Ala Ala Tyr His 
    210                 215                 220                 


Ile Ile Asp Ala Lys Gly Ser Thr Ser Tyr Gly Ile Gly Met Gly Leu 
225                 230                 235                 240 


Ala Arg Ile Thr Arg Ala Val Ile Gln Asn Gln Asp Val Ala Leu Pro 
                245                 250                 255     


Val Ser Ala Leu Leu Asn Gly Glu Tyr Gly Glu Glu Asp Ile Tyr Ile 
            260                 265                 270         


Gly Thr Pro Ala Ile Ile Asn Arg Arg Gly Ile Arg Arg Val Val Glu 
        275                 280                 285             


Leu Glu Ile Ser Glu His Glu Met Glu Arg Phe Lys His Ser Ala Asn 
    290                 295                 300                 


Thr Leu Arg Ala Ile Gln Glu Gln Ile Phe Ser 
305                 310                 315 


<210>  17
<211>  954
<212>  DNA
<213>  Corynebacterium kutscheri strain DSM 20755


<220>
<221>  CDS
<222>  (1)..(954)
<223>  ldh gene encodingL-lactate-dehydrogenase

<300>
<308>  GenBank CP011312.1
<309>  2015-06-10
<313>  (2203817)..(2204770)

<400>  17
atg aag aaa aac gtc gga aat aaa gtc gtc ctt att ggt gct ggt gac         48
Met Lys Lys Asn Val Gly Asn Lys Val Val Leu Ile Gly Ala Gly Asp           
1               5                   10                  15                

gtc gga gtt gct tac gct tat gct ttg gta aac cag ggc act gca gac         96
Val Gly Val Ala Tyr Ala Tyr Ala Leu Val Asn Gln Gly Thr Ala Asp           
            20                  25                  30                    

cac cta gcc att att gat atc gat gaa aag aag cta gaa ggc aac gtt        144
His Leu Ala Ile Ile Asp Ile Asp Glu Lys Lys Leu Glu Gly Asn Val           
        35                  40                  45                        

aaa gac ctt aac cat ggt gtt gtc tgg tcc gga cat cgc acc acc gtt        192
Lys Asp Leu Asn His Gly Val Val Trp Ser Gly His Arg Thr Thr Val           
    50                  55                  60                            

acc aag gga agc tat gcc gat tgc gct gat gca tcg atg gtt gtg atc        240
Thr Lys Gly Ser Tyr Ala Asp Cys Ala Asp Ala Ser Met Val Val Ile           
65                  70                  75                  80            

tgt gcc ggt gct gct cag aag cca ggc gag acg cgc ttg caa ctg gtg        288
Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Gln Leu Val           
                85                  90                  95                

ggt aag aat atg ggc att atg aaa tcc atc gtc gat gag gtc atg gct        336
Gly Lys Asn Met Gly Ile Met Lys Ser Ile Val Asp Glu Val Met Ala           
            100                 105                 110                   

aat ggt ttc gac gga att ttc ctt att gca tcc aac cca gta gat att        384
Asn Gly Phe Asp Gly Ile Phe Leu Ile Ala Ser Asn Pro Val Asp Ile           
        115                 120                 125                       

ctt acc tac gca gta tgg cag tac tcc ggc ttg gac tgg cac cgt gtt        432
Leu Thr Tyr Ala Val Trp Gln Tyr Ser Gly Leu Asp Trp His Arg Val           
    130                 135                 140                           

att gga tcc ggc acc gtt ttg gat tcg gca cgc ttc cgc tat atg ctc        480
Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu           
145                 150                 155                 160           

ggc gag cgc tac caa gtg aat cca tct tcg att cac gct tat att atc        528
Gly Glu Arg Tyr Gln Val Asn Pro Ser Ser Ile His Ala Tyr Ile Ile           
                165                 170                 175               

ggt gag cac ggc gat act gag cta cca gtg ctg tcc tca gcg acc att        576
Gly Glu His Gly Asp Thr Glu Leu Pro Val Leu Ser Ser Ala Thr Ile           
            180                 185                 190                   

gct ggt gtg tct atg cgc aag cag ttg gag aag aac cca ggc ctg gaa        624
Ala Gly Val Ser Met Arg Lys Gln Leu Glu Lys Asn Pro Gly Leu Glu           
        195                 200                 205                       

gca gaa cta gag aag atc ttc gaa gaa acc cgc gac gcc gct tac aac        672
Ala Glu Leu Glu Lys Ile Phe Glu Glu Thr Arg Asp Ala Ala Tyr Asn           
    210                 215                 220                           

att att gag gcc aag gga tca act tcc tac ggt atc ggc atg ggg ctt        720
Ile Ile Glu Ala Lys Gly Ser Thr Ser Tyr Gly Ile Gly Met Gly Leu           
225                 230                 235                 240           

gct cgc att aca aaa gcg gtt ttg cat aat cag gat gtt gct ttg cca        768
Ala Arg Ile Thr Lys Ala Val Leu His Asn Gln Asp Val Ala Leu Pro           
                245                 250                 255               

tgc tcc gca ttg ttg gaa gga caa tat ggc cag gaa aac att tac att        816
Cys Ser Ala Leu Leu Glu Gly Gln Tyr Gly Gln Glu Asn Ile Tyr Ile           
            260                 265                 270                   

ggt acc cca gct gtg att aat ggt ggt gga atc gag cgc gtt gtt gaa        864
Gly Thr Pro Ala Val Ile Asn Gly Gly Gly Ile Glu Arg Val Val Glu           
        275                 280                 285                       

ctt gaa ctt acc gat cat gag cgg gag cgt ttc acc cac tca gct gat        912
Leu Glu Leu Thr Asp His Glu Arg Glu Arg Phe Thr His Ser Ala Asp           
    290                 295                 300                           

acc ttg cgc tca atc cag gaa gaa ttc ttc cca gct aag taa                954
Thr Leu Arg Ser Ile Gln Glu Glu Phe Phe Pro Ala Lys                       
305                 310                 315                               


<210>  18
<211>  317
<212>  PRT
<213>  Corynebacterium kutscheri strain DSM 20755

<400>  18

Met Lys Lys Asn Val Gly Asn Lys Val Val Leu Ile Gly Ala Gly Asp 
1               5                   10                  15      


Val Gly Val Ala Tyr Ala Tyr Ala Leu Val Asn Gln Gly Thr Ala Asp 
            20                  25                  30          


His Leu Ala Ile Ile Asp Ile Asp Glu Lys Lys Leu Glu Gly Asn Val 
        35                  40                  45              


Lys Asp Leu Asn His Gly Val Val Trp Ser Gly His Arg Thr Thr Val 
    50                  55                  60                  


Thr Lys Gly Ser Tyr Ala Asp Cys Ala Asp Ala Ser Met Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Gln Leu Val 
                85                  90                  95      


Gly Lys Asn Met Gly Ile Met Lys Ser Ile Val Asp Glu Val Met Ala 
            100                 105                 110         


Asn Gly Phe Asp Gly Ile Phe Leu Ile Ala Ser Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Val Trp Gln Tyr Ser Gly Leu Asp Trp His Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu 
145                 150                 155                 160 


Gly Glu Arg Tyr Gln Val Asn Pro Ser Ser Ile His Ala Tyr Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Pro Val Leu Ser Ser Ala Thr Ile 
            180                 185                 190         


Ala Gly Val Ser Met Arg Lys Gln Leu Glu Lys Asn Pro Gly Leu Glu 
        195                 200                 205             


Ala Glu Leu Glu Lys Ile Phe Glu Glu Thr Arg Asp Ala Ala Tyr Asn 
    210                 215                 220                 


Ile Ile Glu Ala Lys Gly Ser Thr Ser Tyr Gly Ile Gly Met Gly Leu 
225                 230                 235                 240 


Ala Arg Ile Thr Lys Ala Val Leu His Asn Gln Asp Val Ala Leu Pro 
                245                 250                 255     


Cys Ser Ala Leu Leu Glu Gly Gln Tyr Gly Gln Glu Asn Ile Tyr Ile 
            260                 265                 270         


Gly Thr Pro Ala Val Ile Asn Gly Gly Gly Ile Glu Arg Val Val Glu 
        275                 280                 285             


Leu Glu Leu Thr Asp His Glu Arg Glu Arg Phe Thr His Ser Ala Asp 
    290                 295                 300                 


Thr Leu Arg Ser Ile Gln Glu Glu Phe Phe Pro Ala Lys 
305                 310                 315         


<210>  19
<211>  1020
<212>  DNA
<213>  Lactococcus lactis subsp. cremoris NZ9000


<220>
<221>  CDS
<222>  (1)..(1020)
<223>  galM gene encoding aldose 1-epimerase

<300>
<308>  GenBank CP002094.1
<309>  2014-01-30
<313>  (2199168)..(2200187)

<400>  19
atg gaa att aca aca aaa gat ttt ggt tta gga agt agc cta att agt         48
Met Glu Ile Thr Thr Lys Asp Phe Gly Leu Gly Ser Ser Leu Ile Ser           
1               5                   10                  15                

cta acg aac aaa aat gat gtt aca att gct ttt aca aac tta gga gct         96
Leu Thr Asn Lys Asn Asp Val Thr Ile Ala Phe Thr Asn Leu Gly Ala           
            20                  25                  30                    

cgc att gtt gat tgg caa aaa gac ggg aaa cat ttt att tta gga ttt        144
Arg Ile Val Asp Trp Gln Lys Asp Gly Lys His Phe Ile Leu Gly Phe           
        35                  40                  45                        

gat tcc gcc caa gaa tat tta gaa aaa gat gct tat cca ggg gcc aca        192
Asp Ser Ala Gln Glu Tyr Leu Glu Lys Asp Ala Tyr Pro Gly Ala Thr           
    50                  55                  60                            

gtt gga cgt aca gct ggc aga atc aaa gat ggt ttg gtt gat att tct        240
Val Gly Arg Thr Ala Gly Arg Ile Lys Asp Gly Leu Val Asp Ile Ser           
65                  70                  75                  80            

gga aaa aca tat cat tta aat caa aat gaa gct ccc caa acc tta cat        288
Gly Lys Thr Tyr His Leu Asn Gln Asn Glu Ala Pro Gln Thr Leu His           
                85                  90                  95                

ggt gga gaa gat agc att cat acc aaa ctt tgg act tat gaa att aat        336
Gly Gly Glu Asp Ser Ile His Thr Lys Leu Trp Thr Tyr Glu Ile Asn           
            100                 105                 110                   

gat tta gga gat gaa gtt caa gtc aaa ttt agc tta gtt tcc aat gat        384
Asp Leu Gly Asp Glu Val Gln Val Lys Phe Ser Leu Val Ser Asn Asp           
        115                 120                 125                       

gga gaa aat gga tat cct ggt aaa ata gag atg tcg gtg act cat tct        432
Gly Glu Asn Gly Tyr Pro Gly Lys Ile Glu Met Ser Val Thr His Ser           
    130                 135                 140                           

ttt gat gaa gag aac aat tgg aaa att aag tat gaa gca att tct gac        480
Phe Asp Glu Glu Asn Asn Trp Lys Ile Lys Tyr Glu Ala Ile Ser Asp           
145                 150                 155                 160           

aaa gat acg gta ttt aat ccc aca gga cat gtc tat ttc aac tta aat        528
Lys Asp Thr Val Phe Asn Pro Thr Gly His Val Tyr Phe Asn Leu Asn           
                165                 170                 175               

ggg gat gct agc aag tct att gaa aat cat caa ctc aag ctt gct gct        576
Gly Asp Ala Ser Lys Ser Ile Glu Asn His Gln Leu Lys Leu Ala Ala           
            180                 185                 190                   

tca aga ttt gta cct tta aaa gat caa aca gaa att gtc cgt ggc gat        624
Ser Arg Phe Val Pro Leu Lys Asp Gln Thr Glu Ile Val Arg Gly Asp           
        195                 200                 205                       

atc gtt gat aca aaa aat act gac tta gac ttc cgt cag gaa aaa caa        672
Ile Val Asp Thr Lys Asn Thr Asp Leu Asp Phe Arg Gln Glu Lys Gln           
    210                 215                 220                           

tta tca aaa gcc tta gag tct agc atg gaa caa gtt caa ctg gtt ggt        720
Leu Ser Lys Ala Leu Glu Ser Ser Met Glu Gln Val Gln Leu Val Gly           
225                 230                 235                 240           

gga att gac cac ccc ttc tta tta gat gaa cag agc ctt gag aaa gaa        768
Gly Ile Asp His Pro Phe Leu Leu Asp Glu Gln Ser Leu Glu Lys Glu           
                245                 250                 255               

caa gcg cgt tta tct tta gat gac ttg tca gtt tcc gtt tat act gac        816
Gln Ala Arg Leu Ser Leu Asp Asp Leu Ser Val Ser Val Tyr Thr Asp           
            260                 265                 270                   

caa cca agt att gta att ttt aca gca aac ttt gga gat ttg ggg acc        864
Gln Pro Ser Ile Val Ile Phe Thr Ala Asn Phe Gly Asp Leu Gly Thr           
        275                 280                 285                       

gtt tat cac ggg aaa aat caa gtt cat cat ggt ggt att acc ttt gaa        912
Val Tyr His Gly Lys Asn Gln Val His His Gly Gly Ile Thr Phe Glu           
    290                 295                 300                           

tgt caa gtt tca ccc ggg tca caa cag att cca gaa ctt gga gac att        960
Cys Gln Val Ser Pro Gly Ser Gln Gln Ile Pro Glu Leu Gly Asp Ile           
305                 310                 315                 320           

agt tta aag gca gga gat gaa tat caa gcc acc acc att tat agt tta       1008
Ser Leu Lys Ala Gly Asp Glu Tyr Gln Ala Thr Thr Ile Tyr Ser Leu           
                325                 330                 335               

cat aca aat taa                                                       1020
His Thr Asn                                                               
                                                                          


<210>  20
<211>  339
<212>  PRT
<213>  Lactococcus lactis subsp. cremoris NZ9000

<400>  20

Met Glu Ile Thr Thr Lys Asp Phe Gly Leu Gly Ser Ser Leu Ile Ser 
1               5                   10                  15      


Leu Thr Asn Lys Asn Asp Val Thr Ile Ala Phe Thr Asn Leu Gly Ala 
            20                  25                  30          


Arg Ile Val Asp Trp Gln Lys Asp Gly Lys His Phe Ile Leu Gly Phe 
        35                  40                  45              


Asp Ser Ala Gln Glu Tyr Leu Glu Lys Asp Ala Tyr Pro Gly Ala Thr 
    50                  55                  60                  


Val Gly Arg Thr Ala Gly Arg Ile Lys Asp Gly Leu Val Asp Ile Ser 
65                  70                  75                  80  


Gly Lys Thr Tyr His Leu Asn Gln Asn Glu Ala Pro Gln Thr Leu His 
                85                  90                  95      


Gly Gly Glu Asp Ser Ile His Thr Lys Leu Trp Thr Tyr Glu Ile Asn 
            100                 105                 110         


Asp Leu Gly Asp Glu Val Gln Val Lys Phe Ser Leu Val Ser Asn Asp 
        115                 120                 125             


Gly Glu Asn Gly Tyr Pro Gly Lys Ile Glu Met Ser Val Thr His Ser 
    130                 135                 140                 


Phe Asp Glu Glu Asn Asn Trp Lys Ile Lys Tyr Glu Ala Ile Ser Asp 
145                 150                 155                 160 


Lys Asp Thr Val Phe Asn Pro Thr Gly His Val Tyr Phe Asn Leu Asn 
                165                 170                 175     


Gly Asp Ala Ser Lys Ser Ile Glu Asn His Gln Leu Lys Leu Ala Ala 
            180                 185                 190         


Ser Arg Phe Val Pro Leu Lys Asp Gln Thr Glu Ile Val Arg Gly Asp 
        195                 200                 205             


Ile Val Asp Thr Lys Asn Thr Asp Leu Asp Phe Arg Gln Glu Lys Gln 
    210                 215                 220                 


Leu Ser Lys Ala Leu Glu Ser Ser Met Glu Gln Val Gln Leu Val Gly 
225                 230                 235                 240 


Gly Ile Asp His Pro Phe Leu Leu Asp Glu Gln Ser Leu Glu Lys Glu 
                245                 250                 255     


Gln Ala Arg Leu Ser Leu Asp Asp Leu Ser Val Ser Val Tyr Thr Asp 
            260                 265                 270         


Gln Pro Ser Ile Val Ile Phe Thr Ala Asn Phe Gly Asp Leu Gly Thr 
        275                 280                 285             


Val Tyr His Gly Lys Asn Gln Val His His Gly Gly Ile Thr Phe Glu 
    290                 295                 300                 


Cys Gln Val Ser Pro Gly Ser Gln Gln Ile Pro Glu Leu Gly Asp Ile 
305                 310                 315                 320 


Ser Leu Lys Ala Gly Asp Glu Tyr Gln Ala Thr Thr Ile Tyr Ser Leu 
                325                 330                 335     


His Thr Asn 
            


<210>  21
<211>  1020
<212>  DNA
<213>  Lactococcus lactis subsp. lactis NCDO 2118


<220>
<221>  CDS
<222>  (1)..(1020)
<223>  galM gene encoding Aldose 1-epimerase

<300>
<308>  GenBank CP009054.1
<309>  2014-10-21
<313>  (2244316)..(2245335)

<400>  21
atg gaa att aaa ata aga gat ttt ggc tta gga agt gac tta att agt         48
Met Glu Ile Lys Ile Arg Asp Phe Gly Leu Gly Ser Asp Leu Ile Ser           
1               5                   10                  15                

cta acc aat aaa gca ggt gtc aca att tct ttt aca aat ctg ggc gct         96
Leu Thr Asn Lys Ala Gly Val Thr Ile Ser Phe Thr Asn Leu Gly Ala           
            20                  25                  30                    

cgg att gtt gac tgg caa aaa gat gga aag cat ctg att cta ggc ttt        144
Arg Ile Val Asp Trp Gln Lys Asp Gly Lys His Leu Ile Leu Gly Phe           
        35                  40                  45                        

gat tca gct aaa gaa tat tta gaa aaa gat gcc tat cct ggt gca aca        192
Asp Ser Ala Lys Glu Tyr Leu Glu Lys Asp Ala Tyr Pro Gly Ala Thr           
    50                  55                  60                            

gtt gga cct aca gca gga aga att aag gat ggt ttg gtc aaa att tct        240
Val Gly Pro Thr Ala Gly Arg Ile Lys Asp Gly Leu Val Lys Ile Ser           
65                  70                  75                  80            

ggg aaa gat tat atc tta aat caa aat gaa ggc cct caa acc tta cat        288
Gly Lys Asp Tyr Ile Leu Asn Gln Asn Glu Gly Pro Gln Thr Leu His           
                85                  90                  95                

ggt ggg gaa gaa agt att cat act aaa ctt tgg aca tat gaa gtt acc        336
Gly Gly Glu Glu Ser Ile His Thr Lys Leu Trp Thr Tyr Glu Val Thr           
            100                 105                 110                   

gat tta gga gct gaa gtt caa gtc aaa ttt tcc tta gtt tct aat gac        384
Asp Leu Gly Ala Glu Val Gln Val Lys Phe Ser Leu Val Ser Asn Asp           
        115                 120                 125                       

gga aca aat ggt tat cct ggt aaa ata gaa atg tca gta act cat tct        432
Gly Thr Asn Gly Tyr Pro Gly Lys Ile Glu Met Ser Val Thr His Ser           
    130                 135                 140                           

ttt gat gag gac aat aag tgg aaa att cat tat gag gcc att tct gat        480
Phe Asp Glu Asp Asn Lys Trp Lys Ile His Tyr Glu Ala Ile Ser Asp           
145                 150                 155                 160           

aaa gac act gtg ttt aat cca act ggg cat gtc tat ttt aat ttg aat        528
Lys Asp Thr Val Phe Asn Pro Thr Gly His Val Tyr Phe Asn Leu Asn           
                165                 170                 175               

ggt gat gct agt gaa tct gtt gaa aat cat gga ctt cga ctg gcc gct        576
Gly Asp Ala Ser Glu Ser Val Glu Asn His Gly Leu Arg Leu Ala Ala           
            180                 185                 190                   

tca aga ttt gtt cct tta aaa gac caa aca gaa att gtt cgt ggt gat        624
Ser Arg Phe Val Pro Leu Lys Asp Gln Thr Glu Ile Val Arg Gly Asp           
        195                 200                 205                       

atc gtt gat ata aaa aat aca gat ttg gat ttc cgt cag gga aaa caa        672
Ile Val Asp Ile Lys Asn Thr Asp Leu Asp Phe Arg Gln Gly Lys Gln           
    210                 215                 220                           

tta tca aat gcc ctc aat tct aat atg gaa caa gtt caa tta gtt aaa        720
Leu Ser Asn Ala Leu Asn Ser Asn Met Glu Gln Val Gln Leu Val Lys           
225                 230                 235                 240           

gga att gac cac cct ttc ttg tta gac cag tta gga ctt gat aaa gaa        768
Gly Ile Asp His Pro Phe Leu Leu Asp Gln Leu Gly Leu Asp Lys Glu           
                245                 250                 255               

caa gct cgt tta acg ctt gat gat act tca att tca gtc ttt act gac        816
Gln Ala Arg Leu Thr Leu Asp Asp Thr Ser Ile Ser Val Phe Thr Asp           
            260                 265                 270                   

caa cca agt att gtg ata ttt aca gca aat ttt ggt gat tta gga act        864
Gln Pro Ser Ile Val Ile Phe Thr Ala Asn Phe Gly Asp Leu Gly Thr           
        275                 280                 285                       

ctt tat cat ggg aaa aag caa gtg cac cat ggt gga att act ttt gaa        912
Leu Tyr His Gly Lys Lys Gln Val His His Gly Gly Ile Thr Phe Glu           
    290                 295                 300                           

tgt caa gtt tca cct ggg tct gag caa att cca gaa ctt gga gat atc        960
Cys Gln Val Ser Pro Gly Ser Glu Gln Ile Pro Glu Leu Gly Asp Ile           
305                 310                 315                 320           

agc cta aaa gcg gga gaa aaa tat caa gca acc aca att tac agc ttg       1008
Ser Leu Lys Ala Gly Glu Lys Tyr Gln Ala Thr Thr Ile Tyr Ser Leu           
                325                 330                 335               

cat aca aaa taa                                                       1020
His Thr Lys                                                               
                                                                          


<210>  22
<211>  339
<212>  PRT
<213>  Lactococcus lactis subsp. lactis NCDO 2118

<400>  22

Met Glu Ile Lys Ile Arg Asp Phe Gly Leu Gly Ser Asp Leu Ile Ser 
1               5                   10                  15      


Leu Thr Asn Lys Ala Gly Val Thr Ile Ser Phe Thr Asn Leu Gly Ala 
            20                  25                  30          


Arg Ile Val Asp Trp Gln Lys Asp Gly Lys His Leu Ile Leu Gly Phe 
        35                  40                  45              


Asp Ser Ala Lys Glu Tyr Leu Glu Lys Asp Ala Tyr Pro Gly Ala Thr 
    50                  55                  60                  


Val Gly Pro Thr Ala Gly Arg Ile Lys Asp Gly Leu Val Lys Ile Ser 
65                  70                  75                  80  


Gly Lys Asp Tyr Ile Leu Asn Gln Asn Glu Gly Pro Gln Thr Leu His 
                85                  90                  95      


Gly Gly Glu Glu Ser Ile His Thr Lys Leu Trp Thr Tyr Glu Val Thr 
            100                 105                 110         


Asp Leu Gly Ala Glu Val Gln Val Lys Phe Ser Leu Val Ser Asn Asp 
        115                 120                 125             


Gly Thr Asn Gly Tyr Pro Gly Lys Ile Glu Met Ser Val Thr His Ser 
    130                 135                 140                 


Phe Asp Glu Asp Asn Lys Trp Lys Ile His Tyr Glu Ala Ile Ser Asp 
145                 150                 155                 160 


Lys Asp Thr Val Phe Asn Pro Thr Gly His Val Tyr Phe Asn Leu Asn 
                165                 170                 175     


Gly Asp Ala Ser Glu Ser Val Glu Asn His Gly Leu Arg Leu Ala Ala 
            180                 185                 190         


Ser Arg Phe Val Pro Leu Lys Asp Gln Thr Glu Ile Val Arg Gly Asp 
        195                 200                 205             


Ile Val Asp Ile Lys Asn Thr Asp Leu Asp Phe Arg Gln Gly Lys Gln 
    210                 215                 220                 


Leu Ser Asn Ala Leu Asn Ser Asn Met Glu Gln Val Gln Leu Val Lys 
225                 230                 235                 240 


Gly Ile Asp His Pro Phe Leu Leu Asp Gln Leu Gly Leu Asp Lys Glu 
                245                 250                 255     


Gln Ala Arg Leu Thr Leu Asp Asp Thr Ser Ile Ser Val Phe Thr Asp 
            260                 265                 270         


Gln Pro Ser Ile Val Ile Phe Thr Ala Asn Phe Gly Asp Leu Gly Thr 
        275                 280                 285             


Leu Tyr His Gly Lys Lys Gln Val His His Gly Gly Ile Thr Phe Glu 
    290                 295                 300                 


Cys Gln Val Ser Pro Gly Ser Glu Gln Ile Pro Glu Leu Gly Asp Ile 
305                 310                 315                 320 


Ser Leu Lys Ala Gly Glu Lys Tyr Gln Ala Thr Thr Ile Tyr Ser Leu 
                325                 330                 335     


His Thr Lys 
            


<210>  23
<211>  1020
<212>  DNA
<213>  Lactococcus lactis subsp. cremoris strain JM1


<220>
<221>  CDS
<222>  (1)..(1020)
<223>  galM gene encoding Aldose 1-epimerase

<300>
<308>  GanBank CP015899.1
<309>  2017-04-04
<313>  (306262)..(307281)

<400>  23
atg gaa act aca aca aaa gat ttt ggt tta gga agt agc cta att agt         48
Met Glu Thr Thr Thr Lys Asp Phe Gly Leu Gly Ser Ser Leu Ile Ser           
1               5                   10                  15                

cta acg aac aaa aat gat gtt aca att gct ttt aca aac tta gga gct         96
Leu Thr Asn Lys Asn Asp Val Thr Ile Ala Phe Thr Asn Leu Gly Ala           
            20                  25                  30                    

cgc att gtt gat tgg caa aaa gac ggg aaa cat ttt gtt tta gga ttt        144
Arg Ile Val Asp Trp Gln Lys Asp Gly Lys His Phe Val Leu Gly Phe           
        35                  40                  45                        

gat tcc gcc caa gaa tac tta gaa aaa gat gct tat cca ggg gcc aca        192
Asp Ser Ala Gln Glu Tyr Leu Glu Lys Asp Ala Tyr Pro Gly Ala Thr           
    50                  55                  60                            

gtt gga cgt aca gct ggc aga atc aaa gat ggt ttg gtt gat att tct        240
Val Gly Arg Thr Ala Gly Arg Ile Lys Asp Gly Leu Val Asp Ile Ser           
65                  70                  75                  80            

gga aaa aca tat cat tta aat caa aat gaa gct ccc caa acc tta cat        288
Gly Lys Thr Tyr His Leu Asn Gln Asn Glu Ala Pro Gln Thr Leu His           
                85                  90                  95                

ggt gga gaa gat agc att cat acc aaa ctt tgg act tat gaa att aat        336
Gly Gly Glu Asp Ser Ile His Thr Lys Leu Trp Thr Tyr Glu Ile Asn           
            100                 105                 110                   

gat tta gga gat gaa gtc caa gta aaa ttt agc tta gtt tcc aat gat        384
Asp Leu Gly Asp Glu Val Gln Val Lys Phe Ser Leu Val Ser Asn Asp           
        115                 120                 125                       

gga gaa aat gga tat cct ggt aaa ata gag atg tcg gtg act cat tct        432
Gly Glu Asn Gly Tyr Pro Gly Lys Ile Glu Met Ser Val Thr His Ser           
    130                 135                 140                           

ttt gat gaa gag aac aat tgg aaa att aag tat gaa gca att tct gac        480
Phe Asp Glu Glu Asn Asn Trp Lys Ile Lys Tyr Glu Ala Ile Ser Asp           
145                 150                 155                 160           

aaa gat acg gta ttt aat ccc aca gga cat gtc tat ttc aac tta aat        528
Lys Asp Thr Val Phe Asn Pro Thr Gly His Val Tyr Phe Asn Leu Asn           
                165                 170                 175               

ggg gat gct agc aag tct gtt gaa aat cat caa ctc aag ctt gct gct        576
Gly Asp Ala Ser Lys Ser Val Glu Asn His Gln Leu Lys Leu Ala Ala           
            180                 185                 190                   

tca aga ttt gta cct tta aaa gat caa aca gaa att gtc cgt ggc gat        624
Ser Arg Phe Val Pro Leu Lys Asp Gln Thr Glu Ile Val Arg Gly Asp           
        195                 200                 205                       

atc gtt gat ata aaa aat act gac tta gac ttc cgt cag gaa aaa caa        672
Ile Val Asp Ile Lys Asn Thr Asp Leu Asp Phe Arg Gln Glu Lys Gln           
    210                 215                 220                           

tta tca aaa gcc tta gag tct agc atg gaa caa gtt caa ctg gtt ggt        720
Leu Ser Lys Ala Leu Glu Ser Ser Met Glu Gln Val Gln Leu Val Gly           
225                 230                 235                 240           

gga att gac cac ccc ttc tta tta gat gaa cag agc ctt gag aaa gaa        768
Gly Ile Asp His Pro Phe Leu Leu Asp Glu Gln Ser Leu Glu Lys Glu           
                245                 250                 255               

caa gcg cgt tta tct tta aat gac ttg tca gtt tcc gtt tat act gac        816
Gln Ala Arg Leu Ser Leu Asn Asp Leu Ser Val Ser Val Tyr Thr Asp           
            260                 265                 270                   

caa cca agt att gta att ttt aca gca aac ttt gga gat ttg ggg acc        864
Gln Pro Ser Ile Val Ile Phe Thr Ala Asn Phe Gly Asp Leu Gly Thr           
        275                 280                 285                       

gtt tat cac ggg aaa aat caa gtt cat cat ggt ggt att acc ttt gaa        912
Val Tyr His Gly Lys Asn Gln Val His His Gly Gly Ile Thr Phe Glu           
    290                 295                 300                           

tgt caa gtt tca ccc ggg tca caa cag att cca gaa ctt gga gac att        960
Cys Gln Val Ser Pro Gly Ser Gln Gln Ile Pro Glu Leu Gly Asp Ile           
305                 310                 315                 320           

agt tta aag gcg gga gat gaa tat caa gcc acc acc att tat agt tta       1008
Ser Leu Lys Ala Gly Asp Glu Tyr Gln Ala Thr Thr Ile Tyr Ser Leu           
                325                 330                 335               

cat aca aat taa                                                       1020
His Thr Asn                                                               
                                                                          


<210>  24
<211>  339
<212>  PRT
<213>  Lactococcus lactis subsp. cremoris strain JM1

<400>  24

Met Glu Thr Thr Thr Lys Asp Phe Gly Leu Gly Ser Ser Leu Ile Ser 
1               5                   10                  15      


Leu Thr Asn Lys Asn Asp Val Thr Ile Ala Phe Thr Asn Leu Gly Ala 
            20                  25                  30          


Arg Ile Val Asp Trp Gln Lys Asp Gly Lys His Phe Val Leu Gly Phe 
        35                  40                  45              


Asp Ser Ala Gln Glu Tyr Leu Glu Lys Asp Ala Tyr Pro Gly Ala Thr 
    50                  55                  60                  


Val Gly Arg Thr Ala Gly Arg Ile Lys Asp Gly Leu Val Asp Ile Ser 
65                  70                  75                  80  


Gly Lys Thr Tyr His Leu Asn Gln Asn Glu Ala Pro Gln Thr Leu His 
                85                  90                  95      


Gly Gly Glu Asp Ser Ile His Thr Lys Leu Trp Thr Tyr Glu Ile Asn 
            100                 105                 110         


Asp Leu Gly Asp Glu Val Gln Val Lys Phe Ser Leu Val Ser Asn Asp 
        115                 120                 125             


Gly Glu Asn Gly Tyr Pro Gly Lys Ile Glu Met Ser Val Thr His Ser 
    130                 135                 140                 


Phe Asp Glu Glu Asn Asn Trp Lys Ile Lys Tyr Glu Ala Ile Ser Asp 
145                 150                 155                 160 


Lys Asp Thr Val Phe Asn Pro Thr Gly His Val Tyr Phe Asn Leu Asn 
                165                 170                 175     


Gly Asp Ala Ser Lys Ser Val Glu Asn His Gln Leu Lys Leu Ala Ala 
            180                 185                 190         


Ser Arg Phe Val Pro Leu Lys Asp Gln Thr Glu Ile Val Arg Gly Asp 
        195                 200                 205             


Ile Val Asp Ile Lys Asn Thr Asp Leu Asp Phe Arg Gln Glu Lys Gln 
    210                 215                 220                 


Leu Ser Lys Ala Leu Glu Ser Ser Met Glu Gln Val Gln Leu Val Gly 
225                 230                 235                 240 


Gly Ile Asp His Pro Phe Leu Leu Asp Glu Gln Ser Leu Glu Lys Glu 
                245                 250                 255     


Gln Ala Arg Leu Ser Leu Asn Asp Leu Ser Val Ser Val Tyr Thr Asp 
            260                 265                 270         


Gln Pro Ser Ile Val Ile Phe Thr Ala Asn Phe Gly Asp Leu Gly Thr 
        275                 280                 285             


Val Tyr His Gly Lys Asn Gln Val His His Gly Gly Ile Thr Phe Glu 
    290                 295                 300                 


Cys Gln Val Ser Pro Gly Ser Gln Gln Ile Pro Glu Leu Gly Asp Ile 
305                 310                 315                 320 


Ser Leu Lys Ala Gly Asp Glu Tyr Gln Ala Thr Thr Ile Tyr Ser Leu 
                325                 330                 335     


His Thr Asn 
            


<210>  25
<211>  1200
<212>  DNA
<213>  Lactococcus lactis subsp. cremoris NZ9000


<220>
<221>  CDS
<222>  (1)..(1200)
<223>  galK gene encoding galactokinase

<300>
<308>  GenBank CP002094.1
<309>  2014-01-30
<313>  (2197942)..(2199141)

<400>  25
atg tca ata gtt gtc gaa aat agt act gta tta tca gcg tta aca gaa         48
Met Ser Ile Val Val Glu Asn Ser Thr Val Leu Ser Ala Leu Thr Glu           
1               5                   10                  15                

aaa ttt gca gaa gtt ttt gga gat aca aaa aaa gtt gaa tac ttt ttc         96
Lys Phe Ala Glu Val Phe Gly Asp Thr Lys Lys Val Glu Tyr Phe Phe           
            20                  25                  30                    

agt cca gga cgg att aat ctg att ggt gaa cat act gat tac aat ggg        144
Ser Pro Gly Arg Ile Asn Leu Ile Gly Glu His Thr Asp Tyr Asn Gly           
        35                  40                  45                        

gga tat gtt ttc cca gca tca att aca atc gga acg aca gga ctt gct        192
Gly Tyr Val Phe Pro Ala Ser Ile Thr Ile Gly Thr Thr Gly Leu Ala           
    50                  55                  60                            

cgt ttg cga gaa gat aat aaa gtc aaa ctt tac tca gaa aat ttt cct        240
Arg Leu Arg Glu Asp Asn Lys Val Lys Leu Tyr Ser Glu Asn Phe Pro           
65                  70                  75                  80            

aaa ttg ggc gtc atc gaa ttt gac tta gat gat gtt gaa aat aag gat        288
Lys Leu Gly Val Ile Glu Phe Asp Leu Asp Asp Val Glu Asn Lys Asp           
                85                  90                  95                

ggt gaa ctt tgg tct aac tat gtc aaa gga atg att gtc atg ctc aaa        336
Gly Glu Leu Trp Ser Asn Tyr Val Lys Gly Met Ile Val Met Leu Lys           
            100                 105                 110                   

gga gca gga tat gaa att gac aaa ggt ttt gaa ctg ttg att aaa gga        384
Gly Ala Gly Tyr Glu Ile Asp Lys Gly Phe Glu Leu Leu Ile Lys Gly           
        115                 120                 125                       

gaa att cct aca gca tca ggc ctt tcg tca tca gct tca ctt gag ctt        432
Glu Ile Pro Thr Ala Ser Gly Leu Ser Ser Ser Ala Ser Leu Glu Leu           
    130                 135                 140                           

tta gtg ggt gtt gtt ttg gat gat tta ttt aag cta agt gtt cct cgt        480
Leu Val Gly Val Val Leu Asp Asp Leu Phe Lys Leu Ser Val Pro Arg           
145                 150                 155                 160           

ctt gaa ctg gtt caa ttg gga caa aaa aca gaa aat gat tat att ggt        528
Leu Glu Leu Val Gln Leu Gly Gln Lys Thr Glu Asn Asp Tyr Ile Gly           
                165                 170                 175               

gtc aac tcc gga att ttg gac caa ttc gcc att ggt ttt ggt gaa gtc        576
Val Asn Ser Gly Ile Leu Asp Gln Phe Ala Ile Gly Phe Gly Glu Val           
            180                 185                 190                   

aaa aag gca atc ttg ttg gat tgc aac act tta aaa tat gaa atg gtt        624
Lys Lys Ala Ile Leu Leu Asp Cys Asn Thr Leu Lys Tyr Glu Met Val           
        195                 200                 205                       

cct gtt gaa ctt cgt gat tat gat att gtt atc atg aac act aac aaa        672
Pro Val Glu Leu Arg Asp Tyr Asp Ile Val Ile Met Asn Thr Asn Lys           
    210                 215                 220                           

ccg cgg gca ttg act gaa tca aaa tac aac gaa cgt ttt gct gaa aca        720
Pro Arg Ala Leu Thr Glu Ser Lys Tyr Asn Glu Arg Phe Ala Glu Thr           
225                 230                 235                 240           

cgt gaa gca ctc aaa aga atg caa act aaa ttg gac att caa tca ctt        768
Arg Glu Ala Leu Lys Arg Met Gln Thr Lys Leu Asp Ile Gln Ser Leu           
                245                 250                 255               

gga gaa cta tca aat gaa gaa ttt gat gcc aat acc gat ttg ata ggt        816
Gly Glu Leu Ser Asn Glu Glu Phe Asp Ala Asn Thr Asp Leu Ile Gly           
            260                 265                 270                   

gat gaa aca tta att aaa cgt gca cgt cat gcc gtt tat gaa aat aat        864
Asp Glu Thr Leu Ile Lys Arg Ala Arg His Ala Val Tyr Glu Asn Asn           
        275                 280                 285                       

cgg acg aaa att gcc caa aag gca ttt gtt gct gga aat cta aca aaa        912
Arg Thr Lys Ile Ala Gln Lys Ala Phe Val Ala Gly Asn Leu Thr Lys           
    290                 295                 300                           

ttt gga gaa ctt ctt aat gct tca cac gct tct tta aaa gat gat tac        960
Phe Gly Glu Leu Leu Asn Ala Ser His Ala Ser Leu Lys Asp Asp Tyr           
305                 310                 315                 320           

gaa gtc act gga ctt gaa ctt gat acc tta gca gaa act gct caa aaa       1008
Glu Val Thr Gly Leu Glu Leu Asp Thr Leu Ala Glu Thr Ala Gln Lys           
                325                 330                 335               

caa gcc ggc gta tta ggg gct cga atg act gga gct gga ttt ggt ggt       1056
Gln Ala Gly Val Leu Gly Ala Arg Met Thr Gly Ala Gly Phe Gly Gly           
            340                 345                 350                   

tgt gca atc gct ctt gtt gct cat gac aat gtt tca gcc ttt gaa aaa       1104
Cys Ala Ile Ala Leu Val Ala His Asp Asn Val Ser Ala Phe Glu Lys           
        355                 360                 365                       

gct gtc ggt gaa gtt tac gaa gaa gtt gtc ggt tat cca gca agc ttc       1152
Ala Val Gly Glu Val Tyr Glu Glu Val Val Gly Tyr Pro Ala Ser Phe           
    370                 375                 380                           

tat gtt gct caa att ggt tct ggc tca aca aag cta gat gtt gaa taa       1200
Tyr Val Ala Gln Ile Gly Ser Gly Ser Thr Lys Leu Asp Val Glu               
385                 390                 395                               


<210>  26
<211>  399
<212>  PRT
<213>  Lactococcus lactis subsp. cremoris NZ9000

<400>  26

Met Ser Ile Val Val Glu Asn Ser Thr Val Leu Ser Ala Leu Thr Glu 
1               5                   10                  15      


Lys Phe Ala Glu Val Phe Gly Asp Thr Lys Lys Val Glu Tyr Phe Phe 
            20                  25                  30          


Ser Pro Gly Arg Ile Asn Leu Ile Gly Glu His Thr Asp Tyr Asn Gly 
        35                  40                  45              


Gly Tyr Val Phe Pro Ala Ser Ile Thr Ile Gly Thr Thr Gly Leu Ala 
    50                  55                  60                  


Arg Leu Arg Glu Asp Asn Lys Val Lys Leu Tyr Ser Glu Asn Phe Pro 
65                  70                  75                  80  


Lys Leu Gly Val Ile Glu Phe Asp Leu Asp Asp Val Glu Asn Lys Asp 
                85                  90                  95      


Gly Glu Leu Trp Ser Asn Tyr Val Lys Gly Met Ile Val Met Leu Lys 
            100                 105                 110         


Gly Ala Gly Tyr Glu Ile Asp Lys Gly Phe Glu Leu Leu Ile Lys Gly 
        115                 120                 125             


Glu Ile Pro Thr Ala Ser Gly Leu Ser Ser Ser Ala Ser Leu Glu Leu 
    130                 135                 140                 


Leu Val Gly Val Val Leu Asp Asp Leu Phe Lys Leu Ser Val Pro Arg 
145                 150                 155                 160 


Leu Glu Leu Val Gln Leu Gly Gln Lys Thr Glu Asn Asp Tyr Ile Gly 
                165                 170                 175     


Val Asn Ser Gly Ile Leu Asp Gln Phe Ala Ile Gly Phe Gly Glu Val 
            180                 185                 190         


Lys Lys Ala Ile Leu Leu Asp Cys Asn Thr Leu Lys Tyr Glu Met Val 
        195                 200                 205             


Pro Val Glu Leu Arg Asp Tyr Asp Ile Val Ile Met Asn Thr Asn Lys 
    210                 215                 220                 


Pro Arg Ala Leu Thr Glu Ser Lys Tyr Asn Glu Arg Phe Ala Glu Thr 
225                 230                 235                 240 


Arg Glu Ala Leu Lys Arg Met Gln Thr Lys Leu Asp Ile Gln Ser Leu 
                245                 250                 255     


Gly Glu Leu Ser Asn Glu Glu Phe Asp Ala Asn Thr Asp Leu Ile Gly 
            260                 265                 270         


Asp Glu Thr Leu Ile Lys Arg Ala Arg His Ala Val Tyr Glu Asn Asn 
        275                 280                 285             


Arg Thr Lys Ile Ala Gln Lys Ala Phe Val Ala Gly Asn Leu Thr Lys 
    290                 295                 300                 


Phe Gly Glu Leu Leu Asn Ala Ser His Ala Ser Leu Lys Asp Asp Tyr 
305                 310                 315                 320 


Glu Val Thr Gly Leu Glu Leu Asp Thr Leu Ala Glu Thr Ala Gln Lys 
                325                 330                 335     


Gln Ala Gly Val Leu Gly Ala Arg Met Thr Gly Ala Gly Phe Gly Gly 
            340                 345                 350         


Cys Ala Ile Ala Leu Val Ala His Asp Asn Val Ser Ala Phe Glu Lys 
        355                 360                 365             


Ala Val Gly Glu Val Tyr Glu Glu Val Val Gly Tyr Pro Ala Ser Phe 
    370                 375                 380                 


Tyr Val Ala Gln Ile Gly Ser Gly Ser Thr Lys Leu Asp Val Glu 
385                 390                 395                 


<210>  27
<211>  1200
<212>  DNA
<213>  Lactococcus lactis subsp. lactis strain UC063


<220>
<221>  CDS
<222>  (1)..(1200)
<223>  galK gene encoding galactokinase

<300>
<308>  GenBank CP015905.1
<309>  2017-04-04
<313>  (2008730)..(2009929)

<400>  27
atg tct ata gtt gta gaa aat agt act gta tta tca gca tta aca gaa         48
Met Ser Ile Val Val Glu Asn Ser Thr Val Leu Ser Ala Leu Thr Glu           
1               5                   10                  15                

aaa ttt gca gaa gtt ttt gga gat aca aaa gaa gtt gaa tac ttt ttt         96
Lys Phe Ala Glu Val Phe Gly Asp Thr Lys Glu Val Glu Tyr Phe Phe           
            20                  25                  30                    

agc cca gga cga att aat ttg att ggt gaa cat acc gat tac aat ggg        144
Ser Pro Gly Arg Ile Asn Leu Ile Gly Glu His Thr Asp Tyr Asn Gly           
        35                  40                  45                        

gga tat gtt ttc cca gca tca att ata att gga aca aca gga cta gct        192
Gly Tyr Val Phe Pro Ala Ser Ile Ile Ile Gly Thr Thr Gly Leu Ala           
    50                  55                  60                            

cgt ctg aga gaa gat aaa aaa gtc aaa ctt tac tca gaa aat ttt cct        240
Arg Leu Arg Glu Asp Lys Lys Val Lys Leu Tyr Ser Glu Asn Phe Pro           
65                  70                  75                  80            

aaa tta ggc gtc att gaa ttt gat tta gat gaa gtt gaa aag aaa gat        288
Lys Leu Gly Val Ile Glu Phe Asp Leu Asp Glu Val Glu Lys Lys Asp           
                85                  90                  95                

ggt gag ctt tgg tct aat tat gtt aaa gga atg att gtc atg ctt aaa        336
Gly Glu Leu Trp Ser Asn Tyr Val Lys Gly Met Ile Val Met Leu Lys           
            100                 105                 110                   

gga gca gga tat gaa att gac aaa ggt ttt gaa ttg ttg ata aaa gga        384
Gly Ala Gly Tyr Glu Ile Asp Lys Gly Phe Glu Leu Leu Ile Lys Gly           
        115                 120                 125                       

gaa att cct aca gca tct ggc ctt tca tca tca gca tca ctt gag ctt        432
Glu Ile Pro Thr Ala Ser Gly Leu Ser Ser Ser Ala Ser Leu Glu Leu           
    130                 135                 140                           

tta gtc ggc gtt gtt ttg gat gat tta ttt aac tta aat gtt cca cgt        480
Leu Val Gly Val Val Leu Asp Asp Leu Phe Asn Leu Asn Val Pro Arg           
145                 150                 155                 160           

ctt gaa ttg gtt caa tta gga caa aaa aca gaa aat gat tat att ggt        528
Leu Glu Leu Val Gln Leu Gly Gln Lys Thr Glu Asn Asp Tyr Ile Gly           
                165                 170                 175               

gtt aat tct gga att tta gac caa ttc gct att ggt ttt ggt gaa gtc        576
Val Asn Ser Gly Ile Leu Asp Gln Phe Ala Ile Gly Phe Gly Glu Val           
            180                 185                 190                   

aaa aaa gca atc cta ttg gac tgt aac act cta aaa tat gag atg gtt        624
Lys Lys Ala Ile Leu Leu Asp Cys Asn Thr Leu Lys Tyr Glu Met Val           
        195                 200                 205                       

cct gtt gaa ctt cgt gat tat gat att gtt atc atg aat act aac aaa        672
Pro Val Glu Leu Arg Asp Tyr Asp Ile Val Ile Met Asn Thr Asn Lys           
    210                 215                 220                           

ccg cgg gct ttg aca gaa tca aaa tac aac gaa cgt ttt gct gaa aca        720
Pro Arg Ala Leu Thr Glu Ser Lys Tyr Asn Glu Arg Phe Ala Glu Thr           
225                 230                 235                 240           

cgt gag gcg ctc aaa aga atg caa acg aga ttg gac att caa tca ctt        768
Arg Glu Ala Leu Lys Arg Met Gln Thr Arg Leu Asp Ile Gln Ser Leu           
                245                 250                 255               

gga gaa tta tca aat gaa gaa ttt gat gcc aat act gat ttg att ggg        816
Gly Glu Leu Ser Asn Glu Glu Phe Asp Ala Asn Thr Asp Leu Ile Gly           
            260                 265                 270                   

gat gaa aca tta att aaa cgt gca cgt cat gcc gtt tat gaa aat aat        864
Asp Glu Thr Leu Ile Lys Arg Ala Arg His Ala Val Tyr Glu Asn Asn           
        275                 280                 285                       

cga act aaa att gct caa aaa gca ttt gtt gca ggt aat ttg aca aaa        912
Arg Thr Lys Ile Ala Gln Lys Ala Phe Val Ala Gly Asn Leu Thr Lys           
    290                 295                 300                           

ttt gga gaa ctt ctt aat gct tca cat gct tct ttg aaa gat gat tat        960
Phe Gly Glu Leu Leu Asn Ala Ser His Ala Ser Leu Lys Asp Asp Tyr           
305                 310                 315                 320           

gaa gtc aca gga ctt gaa ctt gat acc tta gca gag act gct caa aaa       1008
Glu Val Thr Gly Leu Glu Leu Asp Thr Leu Ala Glu Thr Ala Gln Lys           
                325                 330                 335               

caa gcc ggt gtc ttg ggg gcc aga atg act gga gcc gga ttt ggc ggt       1056
Gln Ala Gly Val Leu Gly Ala Arg Met Thr Gly Ala Gly Phe Gly Gly           
            340                 345                 350                   

tgt gca atc gct ctt gtt gct cat gac aat gtt tca gcc ttt gaa aaa       1104
Cys Ala Ile Ala Leu Val Ala His Asp Asn Val Ser Ala Phe Glu Lys           
        355                 360                 365                       

gcc gtc ggc caa gtt tac gaa gaa gtt gtc ggt tat cca gca agc ttt       1152
Ala Val Gly Gln Val Tyr Glu Glu Val Val Gly Tyr Pro Ala Ser Phe           
    370                 375                 380                           

tac gtc gct caa att ggt tct ggt tca aca aag ttg gat gtt gaa taa       1200
Tyr Val Ala Gln Ile Gly Ser Gly Ser Thr Lys Leu Asp Val Glu               
385                 390                 395                               


<210>  28
<211>  399
<212>  PRT
<213>  Lactococcus lactis subsp. lactis strain UC063

<400>  28

Met Ser Ile Val Val Glu Asn Ser Thr Val Leu Ser Ala Leu Thr Glu 
1               5                   10                  15      


Lys Phe Ala Glu Val Phe Gly Asp Thr Lys Glu Val Glu Tyr Phe Phe 
            20                  25                  30          


Ser Pro Gly Arg Ile Asn Leu Ile Gly Glu His Thr Asp Tyr Asn Gly 
        35                  40                  45              


Gly Tyr Val Phe Pro Ala Ser Ile Ile Ile Gly Thr Thr Gly Leu Ala 
    50                  55                  60                  


Arg Leu Arg Glu Asp Lys Lys Val Lys Leu Tyr Ser Glu Asn Phe Pro 
65                  70                  75                  80  


Lys Leu Gly Val Ile Glu Phe Asp Leu Asp Glu Val Glu Lys Lys Asp 
                85                  90                  95      


Gly Glu Leu Trp Ser Asn Tyr Val Lys Gly Met Ile Val Met Leu Lys 
            100                 105                 110         


Gly Ala Gly Tyr Glu Ile Asp Lys Gly Phe Glu Leu Leu Ile Lys Gly 
        115                 120                 125             


Glu Ile Pro Thr Ala Ser Gly Leu Ser Ser Ser Ala Ser Leu Glu Leu 
    130                 135                 140                 


Leu Val Gly Val Val Leu Asp Asp Leu Phe Asn Leu Asn Val Pro Arg 
145                 150                 155                 160 


Leu Glu Leu Val Gln Leu Gly Gln Lys Thr Glu Asn Asp Tyr Ile Gly 
                165                 170                 175     


Val Asn Ser Gly Ile Leu Asp Gln Phe Ala Ile Gly Phe Gly Glu Val 
            180                 185                 190         


Lys Lys Ala Ile Leu Leu Asp Cys Asn Thr Leu Lys Tyr Glu Met Val 
        195                 200                 205             


Pro Val Glu Leu Arg Asp Tyr Asp Ile Val Ile Met Asn Thr Asn Lys 
    210                 215                 220                 


Pro Arg Ala Leu Thr Glu Ser Lys Tyr Asn Glu Arg Phe Ala Glu Thr 
225                 230                 235                 240 


Arg Glu Ala Leu Lys Arg Met Gln Thr Arg Leu Asp Ile Gln Ser Leu 
                245                 250                 255     


Gly Glu Leu Ser Asn Glu Glu Phe Asp Ala Asn Thr Asp Leu Ile Gly 
            260                 265                 270         


Asp Glu Thr Leu Ile Lys Arg Ala Arg His Ala Val Tyr Glu Asn Asn 
        275                 280                 285             


Arg Thr Lys Ile Ala Gln Lys Ala Phe Val Ala Gly Asn Leu Thr Lys 
    290                 295                 300                 


Phe Gly Glu Leu Leu Asn Ala Ser His Ala Ser Leu Lys Asp Asp Tyr 
305                 310                 315                 320 


Glu Val Thr Gly Leu Glu Leu Asp Thr Leu Ala Glu Thr Ala Gln Lys 
                325                 330                 335     


Gln Ala Gly Val Leu Gly Ala Arg Met Thr Gly Ala Gly Phe Gly Gly 
            340                 345                 350         


Cys Ala Ile Ala Leu Val Ala His Asp Asn Val Ser Ala Phe Glu Lys 
        355                 360                 365             


Ala Val Gly Gln Val Tyr Glu Glu Val Val Gly Tyr Pro Ala Ser Phe 
    370                 375                 380                 


Tyr Val Ala Gln Ile Gly Ser Gly Ser Thr Lys Leu Asp Val Glu 
385                 390                 395                 


<210>  29
<211>  1200
<212>  DNA
<213>  Lactococcus garvieae Lg2


<220>
<221>  CDS
<222>  (1)..(1200)
<223>  galK gene encoding galactokinase

<300>
<308>  GenBank AP009333.1
<309>  2016-10-07
<313>  (1694398 )..(1695597)

<400>  29
atg aca aca atc gta gaa aac agt aaa gtt tta aca gca tta aca aac         48
Met Thr Thr Ile Val Glu Asn Ser Lys Val Leu Thr Ala Leu Thr Asn           
1               5                   10                  15                

agt ttt gaa aaa gtc ttt gga gat aca gaa aat gtg gaa tat ttc ttt         96
Ser Phe Glu Lys Val Phe Gly Asp Thr Glu Asn Val Glu Tyr Phe Phe           
            20                  25                  30                    

tcg cca gga cgt att aac ttg att ggt gaa cat aca gac tat aat ggc        144
Ser Pro Gly Arg Ile Asn Leu Ile Gly Glu His Thr Asp Tyr Asn Gly           
        35                  40                  45                        

ggc tac gtc ttc ccc gct tca atc aca att ggg aca aca ggt ctg gcc        192
Gly Tyr Val Phe Pro Ala Ser Ile Thr Ile Gly Thr Thr Gly Leu Ala           
    50                  55                  60                            

cgt tta cgt gag gat aca aaa atc aga ctt ttt tca caa aac ttt ccg        240
Arg Leu Arg Glu Asp Thr Lys Ile Arg Leu Phe Ser Gln Asn Phe Pro           
65                  70                  75                  80            

gaa gca ggt ctt atc gaa ttt gat tta act gag gtc aag gaa aaa gag        288
Glu Ala Gly Leu Ile Glu Phe Asp Leu Thr Glu Val Lys Glu Lys Glu           
                85                  90                  95                

gat gac agt tgg tca aat tat gtt aaa gga atg att gtg atg ctt caa        336
Asp Asp Ser Trp Ser Asn Tyr Val Lys Gly Met Ile Val Met Leu Gln           
            100                 105                 110                   

ggc gca ggc tat acc atc gat aaa ggt ttt gaa ctt ctt att aat ggt        384
Gly Ala Gly Tyr Thr Ile Asp Lys Gly Phe Glu Leu Leu Ile Asn Gly           
        115                 120                 125                       

gaa att cca aca gct tct ggt tta tca tct tca gct tct tta gag ctt        432
Glu Ile Pro Thr Ala Ser Gly Leu Ser Ser Ser Ala Ser Leu Glu Leu           
    130                 135                 140                           

tta gtc ggt gta gtt tta gac gac ttg ttt aac tta caa gtc cca cgt        480
Leu Val Gly Val Val Leu Asp Asp Leu Phe Asn Leu Gln Val Pro Arg           
145                 150                 155                 160           

ttg gag ctt gtg caa ctc gga caa aaa act gaa aat gaa ttc att ggt        528
Leu Glu Leu Val Gln Leu Gly Gln Lys Thr Glu Asn Glu Phe Ile Gly           
                165                 170                 175               

gtc aac tct ggt att ttg gac caa ttt gcg att ggt ttt ggt gaa gtg        576
Val Asn Ser Gly Ile Leu Asp Gln Phe Ala Ile Gly Phe Gly Glu Val           
            180                 185                 190                   

aaa aaa gca att ttg ttg gac tgt aat act ctt aaa tat gaa atg gta        624
Lys Lys Ala Ile Leu Leu Asp Cys Asn Thr Leu Lys Tyr Glu Met Val           
        195                 200                 205                       

ccc gta gag tta cgt gat tat gat att gtc atc atg aat aca aat aaa        672
Pro Val Glu Leu Arg Asp Tyr Asp Ile Val Ile Met Asn Thr Asn Lys           
    210                 215                 220                           

cca cgt gct tta aca gaa tca aaa tat aat gag cgt ttt gct gaa aca        720
Pro Arg Ala Leu Thr Glu Ser Lys Tyr Asn Glu Arg Phe Ala Glu Thr           
225                 230                 235                 240           

cgt gaa gca ttg aaa cgt atg caa agt aag tta gct atc gaa tca ctg        768
Arg Glu Ala Leu Lys Arg Met Gln Ser Lys Leu Ala Ile Glu Ser Leu           
                245                 250                 255               

ggg gaa ctt tct aat gag gaa ttt gac gcc aac aca gac ttg att ggc        816
Gly Glu Leu Ser Asn Glu Glu Phe Asp Ala Asn Thr Asp Leu Ile Gly           
            260                 265                 270                   

gat gaa acc ttg att aaa cgt gca cgc cat gcc gta tat gaa aat aac        864
Asp Glu Thr Leu Ile Lys Arg Ala Arg His Ala Val Tyr Glu Asn Asn           
        275                 280                 285                       

cgt act aaa ata gct caa aaa gct ttt gtt gcg ggt aat ttg acg aaa        912
Arg Thr Lys Ile Ala Gln Lys Ala Phe Val Ala Gly Asn Leu Thr Lys           
    290                 295                 300                           

ttt ggt gaa tta ctt aat gct tca cat gct tcc ctc aaa gat gat tat        960
Phe Gly Glu Leu Leu Asn Ala Ser His Ala Ser Leu Lys Asp Asp Tyr           
305                 310                 315                 320           

gaa gtg acg ggg att gag ctt gat acg ctg gct gaa acc gca caa aaa       1008
Glu Val Thr Gly Ile Glu Leu Asp Thr Leu Ala Glu Thr Ala Gln Lys           
                325                 330                 335               

caa gca ggg gtg tta ggt gca cgt atg aca ggt gca ggc ttt gga ggt       1056
Gln Ala Gly Val Leu Gly Ala Arg Met Thr Gly Ala Gly Phe Gly Gly           
            340                 345                 350                   

tgt gca att gct tta gtt gca cat gat aaa gtc gct gat ttt gaa gaa       1104
Cys Ala Ile Ala Leu Val Ala His Asp Lys Val Ala Asp Phe Glu Glu           
        355                 360                 365                       

gca gtt ggt gcg gaa tat gaa aaa gta gtt ggc tac cca gca agc ttc       1152
Ala Val Gly Ala Glu Tyr Glu Lys Val Val Gly Tyr Pro Ala Ser Phe           
    370                 375                 380                           

tat gtc gcc caa atc ggt tca gga tca aca aaa ctg gat gtg gag tag       1200
Tyr Val Ala Gln Ile Gly Ser Gly Ser Thr Lys Leu Asp Val Glu               
385                 390                 395                               


<210>  30
<211>  399
<212>  PRT
<213>  Lactococcus garvieae Lg2

<400>  30

Met Thr Thr Ile Val Glu Asn Ser Lys Val Leu Thr Ala Leu Thr Asn 
1               5                   10                  15      


Ser Phe Glu Lys Val Phe Gly Asp Thr Glu Asn Val Glu Tyr Phe Phe 
            20                  25                  30          


Ser Pro Gly Arg Ile Asn Leu Ile Gly Glu His Thr Asp Tyr Asn Gly 
        35                  40                  45              


Gly Tyr Val Phe Pro Ala Ser Ile Thr Ile Gly Thr Thr Gly Leu Ala 
    50                  55                  60                  


Arg Leu Arg Glu Asp Thr Lys Ile Arg Leu Phe Ser Gln Asn Phe Pro 
65                  70                  75                  80  


Glu Ala Gly Leu Ile Glu Phe Asp Leu Thr Glu Val Lys Glu Lys Glu 
                85                  90                  95      


Asp Asp Ser Trp Ser Asn Tyr Val Lys Gly Met Ile Val Met Leu Gln 
            100                 105                 110         


Gly Ala Gly Tyr Thr Ile Asp Lys Gly Phe Glu Leu Leu Ile Asn Gly 
        115                 120                 125             


Glu Ile Pro Thr Ala Ser Gly Leu Ser Ser Ser Ala Ser Leu Glu Leu 
    130                 135                 140                 


Leu Val Gly Val Val Leu Asp Asp Leu Phe Asn Leu Gln Val Pro Arg 
145                 150                 155                 160 


Leu Glu Leu Val Gln Leu Gly Gln Lys Thr Glu Asn Glu Phe Ile Gly 
                165                 170                 175     


Val Asn Ser Gly Ile Leu Asp Gln Phe Ala Ile Gly Phe Gly Glu Val 
            180                 185                 190         


Lys Lys Ala Ile Leu Leu Asp Cys Asn Thr Leu Lys Tyr Glu Met Val 
        195                 200                 205             


Pro Val Glu Leu Arg Asp Tyr Asp Ile Val Ile Met Asn Thr Asn Lys 
    210                 215                 220                 


Pro Arg Ala Leu Thr Glu Ser Lys Tyr Asn Glu Arg Phe Ala Glu Thr 
225                 230                 235                 240 


Arg Glu Ala Leu Lys Arg Met Gln Ser Lys Leu Ala Ile Glu Ser Leu 
                245                 250                 255     


Gly Glu Leu Ser Asn Glu Glu Phe Asp Ala Asn Thr Asp Leu Ile Gly 
            260                 265                 270         


Asp Glu Thr Leu Ile Lys Arg Ala Arg His Ala Val Tyr Glu Asn Asn 
        275                 280                 285             


Arg Thr Lys Ile Ala Gln Lys Ala Phe Val Ala Gly Asn Leu Thr Lys 
    290                 295                 300                 


Phe Gly Glu Leu Leu Asn Ala Ser His Ala Ser Leu Lys Asp Asp Tyr 
305                 310                 315                 320 


Glu Val Thr Gly Ile Glu Leu Asp Thr Leu Ala Glu Thr Ala Gln Lys 
                325                 330                 335     


Gln Ala Gly Val Leu Gly Ala Arg Met Thr Gly Ala Gly Phe Gly Gly 
            340                 345                 350         


Cys Ala Ile Ala Leu Val Ala His Asp Lys Val Ala Asp Phe Glu Glu 
        355                 360                 365             


Ala Val Gly Ala Glu Tyr Glu Lys Val Val Gly Tyr Pro Ala Ser Phe 
    370                 375                 380                 


Tyr Val Ala Gln Ile Gly Ser Gly Ser Thr Lys Leu Asp Val Glu 
385                 390                 395                 


<210>  31
<211>  1482
<212>  DNA
<213>  Lactococcus lactis subsp. cremoris NZ9000


<220>
<221>  CDS
<222>  (1)..(1482)
<223>  galT gene encoding galactose-1-phosphate uridylyltransferase

<300>
<308>  GenBank CP002094.1
<309>  2014-01-30
<313>  (2196288)..(2197769)

<400>  31
atg tca att tat caa tca att caa gat ttc att agt ctt gct tta caa         48
Met Ser Ile Tyr Gln Ser Ile Gln Asp Phe Ile Ser Leu Ala Leu Gln           
1               5                   10                  15                

aat gga acg att gag cca ctt gat gag ctc tat cat aga aat caa ctt         96
Asn Gly Thr Ile Glu Pro Leu Asp Glu Leu Tyr His Arg Asn Gln Leu           
            20                  25                  30                    

ctt cat ttt ctt ggt cta aat gat tgg gca gaa gtt gat aaa gag gtt        144
Leu His Phe Leu Gly Leu Asn Asp Trp Ala Glu Val Asp Lys Glu Val           
        35                  40                  45                        

cat gaa act aat tca tta att ttg atg gac caa ctt ctg gcg att gca        192
His Glu Thr Asn Ser Leu Ile Leu Met Asp Gln Leu Leu Ala Ile Ala           
    50                  55                  60                            

aat gaa aat aat gtg att gcg aaa ggg caa gat gaa ttt tat gaa gcc        240
Asn Glu Asn Asn Val Ile Ala Lys Gly Gln Asp Glu Phe Tyr Glu Ala           
65                  70                  75                  80            

gct ctg atg aat ttt atg aca cca cgt cca agt aaa att aat cat gat        288
Ala Leu Met Asn Phe Met Thr Pro Arg Pro Ser Lys Ile Asn His Asp           
                85                  90                  95                

ttc tgg gaa aaa tat cag gct tct cca gat gat gca act caa tat ttt        336
Phe Trp Glu Lys Tyr Gln Ala Ser Pro Asp Asp Ala Thr Gln Tyr Phe           
            100                 105                 110                   

tat gaa tta gca cag caa gtg aat caa gta aaa act cgg gat att gca        384
Tyr Glu Leu Ala Gln Gln Val Asn Gln Val Lys Thr Arg Asp Ile Ala           
        115                 120                 125                       

cgc aat att gct ttt agt cat tta aca aaa tat gga aaa cta gaa ata        432
Arg Asn Ile Ala Phe Ser His Leu Thr Lys Tyr Gly Lys Leu Glu Ile           
    130                 135                 140                           

aca att aat ctc tca aaa cca gaa aaa gac ccc aaa gcg att gca gca        480
Thr Ile Asn Leu Ser Lys Pro Glu Lys Asp Pro Lys Ala Ile Ala Ala           
145                 150                 155                 160           

gcc aaa tta gta aag gct tcc tct tat ccg gct tgt caa ctt tgc ttg        528
Ala Lys Leu Val Lys Ala Ser Ser Tyr Pro Ala Cys Gln Leu Cys Leu           
                165                 170                 175               

gaa aat gaa gga ttt tat ggc cta gga aat aag cct gct cgt tcc aat        576
Glu Asn Glu Gly Phe Tyr Gly Leu Gly Asn Lys Pro Ala Arg Ser Asn           
            180                 185                 190                   

cat cga att att caa gtt tca att aac ggc gag gac tgg ggc ttt caa        624
His Arg Ile Ile Gln Val Ser Ile Asn Gly Glu Asp Trp Gly Phe Gln           
        195                 200                 205                       

tat tct cca tac gcc tat ttt aat gaa cac tct att tta tta aat gct        672
Tyr Ser Pro Tyr Ala Tyr Phe Asn Glu His Ser Ile Leu Leu Asn Ala           
    210                 215                 220                           

aaa cat caa cca atg gag att aat aaa cga gct ttt gat aat ctt cta        720
Lys His Gln Pro Met Glu Ile Asn Lys Arg Ala Phe Asp Asn Leu Leu           
225                 230                 235                 240           

gga ttc ttg gat aaa ttt cct aac tat atg att ggt tca aat gca gat        768
Gly Phe Leu Asp Lys Phe Pro Asn Tyr Met Ile Gly Ser Asn Ala Asp           
                245                 250                 255               

tta cca att gtg ggt ggt tca att ttg aca cat gat cat tat caa gca        816
Leu Pro Ile Val Gly Gly Ser Ile Leu Thr His Asp His Tyr Gln Ala           
            260                 265                 270                   

ggt cgt cat gat ttt cca atg gca aag gct gaa ctt cgt gaa act att        864
Gly Arg His Asp Phe Pro Met Ala Lys Ala Glu Leu Arg Glu Thr Ile           
        275                 280                 285                       

gaa ctc gct cat ttt cca gaa gtt tct tgt ggg ata gtt aat tgg cca        912
Glu Leu Ala His Phe Pro Glu Val Ser Cys Gly Ile Val Asn Trp Pro           
    290                 295                 300                           

atg tca gtc cta aga tta gca agt gaa aat caa gta gaa ctt tca aaa        960
Met Ser Val Leu Arg Leu Ala Ser Glu Asn Gln Val Glu Leu Ser Lys           
305                 310                 315                 320           

gct gcg gat gac ttt tta aaa aaa tgg caa gtt tat agt gat gaa agt       1008
Ala Ala Asp Asp Phe Leu Lys Lys Trp Gln Val Tyr Ser Asp Glu Ser           
                325                 330                 335               

ctt cag att aaa gca aaa agt aca gat gga aca cct cat cat acc att       1056
Leu Gln Ile Lys Ala Lys Ser Thr Asp Gly Thr Pro His His Thr Ile           
            340                 345                 350                   

acg ccg att gct cga att cga gat gga aaa tat gaa tta gat ttg gtc       1104
Thr Pro Ile Ala Arg Ile Arg Asp Gly Lys Tyr Glu Leu Asp Leu Val           
        355                 360                 365                       

tta cgc gat aat aat act aat gaa aaa tat cca gat ggt att ttt cat       1152
Leu Arg Asp Asn Asn Thr Asn Glu Lys Tyr Pro Asp Gly Ile Phe His           
    370                 375                 380                           

cca cat cca gcc cta cac cat att aaa aaa gaa aat att ggt tta att       1200
Pro His Pro Ala Leu His His Ile Lys Lys Glu Asn Ile Gly Leu Ile           
385                 390                 395                 400           

gaa gtg atg gga ctt gca att ttg cct gcc cgt ttg gga acg gaa ctt       1248
Glu Val Met Gly Leu Ala Ile Leu Pro Ala Arg Leu Gly Thr Glu Leu           
                405                 410                 415               

ttg gag gtt gaa aag tat ctt ctt aat cag gac aac caa atg gac gaa       1296
Leu Glu Val Glu Lys Tyr Leu Leu Asn Gln Asp Asn Gln Met Asp Glu           
            420                 425                 430                   

att cat aaa gct tgg gct gaa cag ctt aaa aat gag gaa cat ttt act       1344
Ile His Lys Ala Trp Ala Glu Gln Leu Lys Asn Glu Glu His Phe Thr           
        435                 440                 445                       

aga gaa acg gtt cat gcc act gtt caa ggg gca gta gga gaa gtg ttt       1392
Arg Glu Thr Val His Ala Thr Val Gln Gly Ala Val Gly Glu Val Phe           
    450                 455                 460                           

gaa gaa gtc cta aaa gac gca ggt gta ttt aag gat act caa gaa gga       1440
Glu Glu Val Leu Lys Asp Ala Gly Val Phe Lys Asp Thr Gln Glu Gly           
465                 470                 475                 480           

cat gaa ggt ttt cgt aaa ttt att gat ttt gtg aat caa taa               1482
His Glu Gly Phe Arg Lys Phe Ile Asp Phe Val Asn Gln                       
                485                 490                                   


<210>  32
<211>  493
<212>  PRT
<213>  Lactococcus lactis subsp. cremoris NZ9000

<400>  32

Met Ser Ile Tyr Gln Ser Ile Gln Asp Phe Ile Ser Leu Ala Leu Gln 
1               5                   10                  15      


Asn Gly Thr Ile Glu Pro Leu Asp Glu Leu Tyr His Arg Asn Gln Leu 
            20                  25                  30          


Leu His Phe Leu Gly Leu Asn Asp Trp Ala Glu Val Asp Lys Glu Val 
        35                  40                  45              


His Glu Thr Asn Ser Leu Ile Leu Met Asp Gln Leu Leu Ala Ile Ala 
    50                  55                  60                  


Asn Glu Asn Asn Val Ile Ala Lys Gly Gln Asp Glu Phe Tyr Glu Ala 
65                  70                  75                  80  


Ala Leu Met Asn Phe Met Thr Pro Arg Pro Ser Lys Ile Asn His Asp 
                85                  90                  95      


Phe Trp Glu Lys Tyr Gln Ala Ser Pro Asp Asp Ala Thr Gln Tyr Phe 
            100                 105                 110         


Tyr Glu Leu Ala Gln Gln Val Asn Gln Val Lys Thr Arg Asp Ile Ala 
        115                 120                 125             


Arg Asn Ile Ala Phe Ser His Leu Thr Lys Tyr Gly Lys Leu Glu Ile 
    130                 135                 140                 


Thr Ile Asn Leu Ser Lys Pro Glu Lys Asp Pro Lys Ala Ile Ala Ala 
145                 150                 155                 160 


Ala Lys Leu Val Lys Ala Ser Ser Tyr Pro Ala Cys Gln Leu Cys Leu 
                165                 170                 175     


Glu Asn Glu Gly Phe Tyr Gly Leu Gly Asn Lys Pro Ala Arg Ser Asn 
            180                 185                 190         


His Arg Ile Ile Gln Val Ser Ile Asn Gly Glu Asp Trp Gly Phe Gln 
        195                 200                 205             


Tyr Ser Pro Tyr Ala Tyr Phe Asn Glu His Ser Ile Leu Leu Asn Ala 
    210                 215                 220                 


Lys His Gln Pro Met Glu Ile Asn Lys Arg Ala Phe Asp Asn Leu Leu 
225                 230                 235                 240 


Gly Phe Leu Asp Lys Phe Pro Asn Tyr Met Ile Gly Ser Asn Ala Asp 
                245                 250                 255     


Leu Pro Ile Val Gly Gly Ser Ile Leu Thr His Asp His Tyr Gln Ala 
            260                 265                 270         


Gly Arg His Asp Phe Pro Met Ala Lys Ala Glu Leu Arg Glu Thr Ile 
        275                 280                 285             


Glu Leu Ala His Phe Pro Glu Val Ser Cys Gly Ile Val Asn Trp Pro 
    290                 295                 300                 


Met Ser Val Leu Arg Leu Ala Ser Glu Asn Gln Val Glu Leu Ser Lys 
305                 310                 315                 320 


Ala Ala Asp Asp Phe Leu Lys Lys Trp Gln Val Tyr Ser Asp Glu Ser 
                325                 330                 335     


Leu Gln Ile Lys Ala Lys Ser Thr Asp Gly Thr Pro His His Thr Ile 
            340                 345                 350         


Thr Pro Ile Ala Arg Ile Arg Asp Gly Lys Tyr Glu Leu Asp Leu Val 
        355                 360                 365             


Leu Arg Asp Asn Asn Thr Asn Glu Lys Tyr Pro Asp Gly Ile Phe His 
    370                 375                 380                 


Pro His Pro Ala Leu His His Ile Lys Lys Glu Asn Ile Gly Leu Ile 
385                 390                 395                 400 


Glu Val Met Gly Leu Ala Ile Leu Pro Ala Arg Leu Gly Thr Glu Leu 
                405                 410                 415     


Leu Glu Val Glu Lys Tyr Leu Leu Asn Gln Asp Asn Gln Met Asp Glu 
            420                 425                 430         


Ile His Lys Ala Trp Ala Glu Gln Leu Lys Asn Glu Glu His Phe Thr 
        435                 440                 445             


Arg Glu Thr Val His Ala Thr Val Gln Gly Ala Val Gly Glu Val Phe 
    450                 455                 460                 


Glu Glu Val Leu Lys Asp Ala Gly Val Phe Lys Asp Thr Gln Glu Gly 
465                 470                 475                 480 


His Glu Gly Phe Arg Lys Phe Ile Asp Phe Val Asn Gln 
                485                 490             


<210>  33
<211>  1482
<212>  DNA
<213>  Lactococcus lactis subsp. cremoris KW2


<220>
<221>  CDS
<222>  (1)..(1482)
<223>  galT gene enocding galactose-1-phosphate uridylyltransferase

<300>
<308>  GenBank CP004884.1
<309>  2014-01-30
<313>  (2114080)..(2115561)

<400>  33
atg tca att tat caa tca att caa gat ttc att agt ctt gct tta caa         48
Met Ser Ile Tyr Gln Ser Ile Gln Asp Phe Ile Ser Leu Ala Leu Gln           
1               5                   10                  15                

aat gga acg att gag cca ctt gat gag ctc tat cat aga aat caa ctt         96
Asn Gly Thr Ile Glu Pro Leu Asp Glu Leu Tyr His Arg Asn Gln Leu           
            20                  25                  30                    

ctt cat ttt ctt ggt cta aat gat tgg gca gaa gtt gat aaa gag gct        144
Leu His Phe Leu Gly Leu Asn Asp Trp Ala Glu Val Asp Lys Glu Ala           
        35                  40                  45                        

cat gaa act aat tca tta att ttg atg gac caa ctt ctg gtg att gca        192
His Glu Thr Asn Ser Leu Ile Leu Met Asp Gln Leu Leu Val Ile Ala           
    50                  55                  60                            

aat gaa aat aat gtg att gcg aaa ggg caa gat gag ttt tat gaa gcc        240
Asn Glu Asn Asn Val Ile Ala Lys Gly Gln Asp Glu Phe Tyr Glu Ala           
65                  70                  75                  80            

gct ctg atg aat ttt atg aca cca cgt cca agt aaa att aat cat gat        288
Ala Leu Met Asn Phe Met Thr Pro Arg Pro Ser Lys Ile Asn His Asp           
                85                  90                  95                

ttc tgg gaa aaa tat cag gct tct cca gat gct gca act caa tat ttt        336
Phe Trp Glu Lys Tyr Gln Ala Ser Pro Asp Ala Ala Thr Gln Tyr Phe           
            100                 105                 110                   

tat gaa ttg gca cag caa gtg aat caa gta aaa act cgg gat att gca        384
Tyr Glu Leu Ala Gln Gln Val Asn Gln Val Lys Thr Arg Asp Ile Ala           
        115                 120                 125                       

cgc aat ata gct ttt agt cat ttg aca aaa tat gga aaa ctt gaa ata        432
Arg Asn Ile Ala Phe Ser His Leu Thr Lys Tyr Gly Lys Leu Glu Ile           
    130                 135                 140                           

aca att aat ctc tca aaa cca gaa aaa gac ccc aaa gcg att gca gca        480
Thr Ile Asn Leu Ser Lys Pro Glu Lys Asp Pro Lys Ala Ile Ala Ala           
145                 150                 155                 160           

gcc aaa tta gta aag gct tcc tct tat ccg gtt tgt caa ctt tgt ctg        528
Ala Lys Leu Val Lys Ala Ser Ser Tyr Pro Val Cys Gln Leu Cys Leu           
                165                 170                 175               

gaa aat gaa gga ttt tat ggc cta gga aat aag cct gct cgt tcc aat        576
Glu Asn Glu Gly Phe Tyr Gly Leu Gly Asn Lys Pro Ala Arg Ser Asn           
            180                 185                 190                   

cat cga att att caa gtt tca att aac ggc gag gac tgg ggc ttt caa        624
His Arg Ile Ile Gln Val Ser Ile Asn Gly Glu Asp Trp Gly Phe Gln           
        195                 200                 205                       

tat tct cca tac gcc tat ttt aat gaa cac tct att tta tta aat gct        672
Tyr Ser Pro Tyr Ala Tyr Phe Asn Glu His Ser Ile Leu Leu Asn Ala           
    210                 215                 220                           

aaa cat caa cca atg gag att aat aaa cga gct ttt gat aat ctt cta        720
Lys His Gln Pro Met Glu Ile Asn Lys Arg Ala Phe Asp Asn Leu Leu           
225                 230                 235                 240           

gga ttc ttg gat aaa ttt cct aac tat atg att ggt tca aat gca gat        768
Gly Phe Leu Asp Lys Phe Pro Asn Tyr Met Ile Gly Ser Asn Ala Asp           
                245                 250                 255               

tta cca att gtg ggt ggt tca att ttg aca cat gat cat tat caa gca        816
Leu Pro Ile Val Gly Gly Ser Ile Leu Thr His Asp His Tyr Gln Ala           
            260                 265                 270                   

ggt cgt cat gat ttt cca atg gca aag gct gaa ctt cgt gaa act att        864
Gly Arg His Asp Phe Pro Met Ala Lys Ala Glu Leu Arg Glu Thr Ile           
        275                 280                 285                       

gaa ctc gct cat ttt cca gaa gtt tct tgt ggg ata gtt aat tgg cca        912
Glu Leu Ala His Phe Pro Glu Val Ser Cys Gly Ile Val Asn Trp Pro           
    290                 295                 300                           

atg tca gtc cta aga tta gca agt gaa aat caa gta gaa ctt tca aaa        960
Met Ser Val Leu Arg Leu Ala Ser Glu Asn Gln Val Glu Leu Ser Lys           
305                 310                 315                 320           

gct gcg gat gac ttt tta aaa aaa tgg caa gtt tac agt gat gaa agt       1008
Ala Ala Asp Asp Phe Leu Lys Lys Trp Gln Val Tyr Ser Asp Glu Ser           
                325                 330                 335               

ctt cag att aaa gca aaa agt aca gat gga aca cct cat cat acc att       1056
Leu Gln Ile Lys Ala Lys Ser Thr Asp Gly Thr Pro His His Thr Ile           
            340                 345                 350                   

acg ccg att gct cga att cga gat gga aaa tat gaa tta gat ttg gtc       1104
Thr Pro Ile Ala Arg Ile Arg Asp Gly Lys Tyr Glu Leu Asp Leu Val           
        355                 360                 365                       

tta cgc gat aat aat act aat gaa aaa tat cca gat ggt att ttt cat       1152
Leu Arg Asp Asn Asn Thr Asn Glu Lys Tyr Pro Asp Gly Ile Phe His           
    370                 375                 380                           

cca cat cca gcc cta cac cat att aaa aaa gaa aat att ggt tta att       1200
Pro His Pro Ala Leu His His Ile Lys Lys Glu Asn Ile Gly Leu Ile           
385                 390                 395                 400           

gaa gtg atg gga ctt gca att ttg cct gcc cgt ttg gaa acg gaa ctt       1248
Glu Val Met Gly Leu Ala Ile Leu Pro Ala Arg Leu Glu Thr Glu Leu           
                405                 410                 415               

ttg gag gtt gaa aag tat ctt ctt aat cag gac aac caa atg gac gaa       1296
Leu Glu Val Glu Lys Tyr Leu Leu Asn Gln Asp Asn Gln Met Asp Glu           
            420                 425                 430                   

att cat aaa gct tgg gct gaa cag ctt aaa aat gag gaa cat ttt act       1344
Ile His Lys Ala Trp Ala Glu Gln Leu Lys Asn Glu Glu His Phe Thr           
        435                 440                 445                       

aaa gaa acg gtt cat gcc act gtt caa ggg gca gta gga gaa gtg ttt       1392
Lys Glu Thr Val His Ala Thr Val Gln Gly Ala Val Gly Glu Val Phe           
    450                 455                 460                           

gaa gaa gtc cta aaa gac gca ggt gta ttt aag gat act caa gaa gga       1440
Glu Glu Val Leu Lys Asp Ala Gly Val Phe Lys Asp Thr Gln Glu Gly           
465                 470                 475                 480           

cat gaa ggt ttt cgt aaa ttt att gat ttt gtg aat caa taa               1482
His Glu Gly Phe Arg Lys Phe Ile Asp Phe Val Asn Gln                       
                485                 490                                   


<210>  34
<211>  493
<212>  PRT
<213>  Lactococcus lactis subsp. cremoris KW2

<400>  34

Met Ser Ile Tyr Gln Ser Ile Gln Asp Phe Ile Ser Leu Ala Leu Gln 
1               5                   10                  15      


Asn Gly Thr Ile Glu Pro Leu Asp Glu Leu Tyr His Arg Asn Gln Leu 
            20                  25                  30          


Leu His Phe Leu Gly Leu Asn Asp Trp Ala Glu Val Asp Lys Glu Ala 
        35                  40                  45              


His Glu Thr Asn Ser Leu Ile Leu Met Asp Gln Leu Leu Val Ile Ala 
    50                  55                  60                  


Asn Glu Asn Asn Val Ile Ala Lys Gly Gln Asp Glu Phe Tyr Glu Ala 
65                  70                  75                  80  


Ala Leu Met Asn Phe Met Thr Pro Arg Pro Ser Lys Ile Asn His Asp 
                85                  90                  95      


Phe Trp Glu Lys Tyr Gln Ala Ser Pro Asp Ala Ala Thr Gln Tyr Phe 
            100                 105                 110         


Tyr Glu Leu Ala Gln Gln Val Asn Gln Val Lys Thr Arg Asp Ile Ala 
        115                 120                 125             


Arg Asn Ile Ala Phe Ser His Leu Thr Lys Tyr Gly Lys Leu Glu Ile 
    130                 135                 140                 


Thr Ile Asn Leu Ser Lys Pro Glu Lys Asp Pro Lys Ala Ile Ala Ala 
145                 150                 155                 160 


Ala Lys Leu Val Lys Ala Ser Ser Tyr Pro Val Cys Gln Leu Cys Leu 
                165                 170                 175     


Glu Asn Glu Gly Phe Tyr Gly Leu Gly Asn Lys Pro Ala Arg Ser Asn 
            180                 185                 190         


His Arg Ile Ile Gln Val Ser Ile Asn Gly Glu Asp Trp Gly Phe Gln 
        195                 200                 205             


Tyr Ser Pro Tyr Ala Tyr Phe Asn Glu His Ser Ile Leu Leu Asn Ala 
    210                 215                 220                 


Lys His Gln Pro Met Glu Ile Asn Lys Arg Ala Phe Asp Asn Leu Leu 
225                 230                 235                 240 


Gly Phe Leu Asp Lys Phe Pro Asn Tyr Met Ile Gly Ser Asn Ala Asp 
                245                 250                 255     


Leu Pro Ile Val Gly Gly Ser Ile Leu Thr His Asp His Tyr Gln Ala 
            260                 265                 270         


Gly Arg His Asp Phe Pro Met Ala Lys Ala Glu Leu Arg Glu Thr Ile 
        275                 280                 285             


Glu Leu Ala His Phe Pro Glu Val Ser Cys Gly Ile Val Asn Trp Pro 
    290                 295                 300                 


Met Ser Val Leu Arg Leu Ala Ser Glu Asn Gln Val Glu Leu Ser Lys 
305                 310                 315                 320 


Ala Ala Asp Asp Phe Leu Lys Lys Trp Gln Val Tyr Ser Asp Glu Ser 
                325                 330                 335     


Leu Gln Ile Lys Ala Lys Ser Thr Asp Gly Thr Pro His His Thr Ile 
            340                 345                 350         


Thr Pro Ile Ala Arg Ile Arg Asp Gly Lys Tyr Glu Leu Asp Leu Val 
        355                 360                 365             


Leu Arg Asp Asn Asn Thr Asn Glu Lys Tyr Pro Asp Gly Ile Phe His 
    370                 375                 380                 


Pro His Pro Ala Leu His His Ile Lys Lys Glu Asn Ile Gly Leu Ile 
385                 390                 395                 400 


Glu Val Met Gly Leu Ala Ile Leu Pro Ala Arg Leu Glu Thr Glu Leu 
                405                 410                 415     


Leu Glu Val Glu Lys Tyr Leu Leu Asn Gln Asp Asn Gln Met Asp Glu 
            420                 425                 430         


Ile His Lys Ala Trp Ala Glu Gln Leu Lys Asn Glu Glu His Phe Thr 
        435                 440                 445             


Lys Glu Thr Val His Ala Thr Val Gln Gly Ala Val Gly Glu Val Phe 
    450                 455                 460                 


Glu Glu Val Leu Lys Asp Ala Gly Val Phe Lys Asp Thr Gln Glu Gly 
465                 470                 475                 480 


His Glu Gly Phe Arg Lys Phe Ile Asp Phe Val Asn Gln 
                485                 490             


<210>  35
<211>  1482
<212>  DNA
<213>  Lactococcus lactis subsp. lactis strain UC77


<220>
<221>  CDS
<222>  (1)..(1482)
<223>  galT gene enocding galactose-1-phosphate uridylyltransferase

<300>
<308>  GenBank CP015906.1
<309>  2017-04-04
<313>  (2215131)..(2216612)

<400>  35
atg tca att tat caa tca att caa gat ttt att agt ctt gct tta caa         48
Met Ser Ile Tyr Gln Ser Ile Gln Asp Phe Ile Ser Leu Ala Leu Gln           
1               5                   10                  15                

aat gga acg att gag cca ctt gat gag ctc tat cac aga aat caa ctt         96
Asn Gly Thr Ile Glu Pro Leu Asp Glu Leu Tyr His Arg Asn Gln Leu           
            20                  25                  30                    

ctt cat ttt ctt ggt cta aat gat tgg gca gaa gtc gat aaa gaa gct        144
Leu His Phe Leu Gly Leu Asn Asp Trp Ala Glu Val Asp Lys Glu Ala           
        35                  40                  45                        

cac gag aaa gat tcc ttg att tta atg gac caa ctt tta gcg att gca        192
His Glu Lys Asp Ser Leu Ile Leu Met Asp Gln Leu Leu Ala Ile Ala           
    50                  55                  60                            

aat gaa aat aat gtg att gaa aaa gga caa gat gaa ttt tat gaa gcc        240
Asn Glu Asn Asn Val Ile Glu Lys Gly Gln Asp Glu Phe Tyr Glu Ala           
65                  70                  75                  80            

gct ctg atg aat ttt att aca cca cgc cca agt aaa atc aat caa gat        288
Ala Leu Met Asn Phe Ile Thr Pro Arg Pro Ser Lys Ile Asn Gln Asp           
                85                  90                  95                

ttc tgg gaa aaa tat aag act tct cca gat gca gca act caa tat ttt        336
Phe Trp Glu Lys Tyr Lys Thr Ser Pro Asp Ala Ala Thr Gln Tyr Phe           
            100                 105                 110                   

tat gaa ctg gca cag caa gtg aac caa gta aaa act cga gat att aca        384
Tyr Glu Leu Ala Gln Gln Val Asn Gln Val Lys Thr Arg Asp Ile Thr           
        115                 120                 125                       

cgt aat att gcc ttt agt cat ttg aca aaa tat gga aaa ctt gaa ata        432
Arg Asn Ile Ala Phe Ser His Leu Thr Lys Tyr Gly Lys Leu Glu Ile           
    130                 135                 140                           

acg att aat ctc tca aaa cca gaa aaa gac ccc aaa gcc att gcg gca        480
Thr Ile Asn Leu Ser Lys Pro Glu Lys Asp Pro Lys Ala Ile Ala Ala           
145                 150                 155                 160           

gct aaa tta gta aag gct tcc tct tat cca gcc tgt caa ctt tgt ttg        528
Ala Lys Leu Val Lys Ala Ser Ser Tyr Pro Ala Cys Gln Leu Cys Leu           
                165                 170                 175               

gaa aac gaa gga ttt tat ggc ata gga aat aaa cct gct cgt tct aat        576
Glu Asn Glu Gly Phe Tyr Gly Ile Gly Asn Lys Pro Ala Arg Ser Asn           
            180                 185                 190                   

cat cga atc att caa gtc tca att aac ggc gaa gac tgg ggc ttc caa        624
His Arg Ile Ile Gln Val Ser Ile Asn Gly Glu Asp Trp Gly Phe Gln           
        195                 200                 205                       

tat tct cct tat gcc tat ttt aat gaa cac tcg att tta cta aat gct        672
Tyr Ser Pro Tyr Ala Tyr Phe Asn Glu His Ser Ile Leu Leu Asn Ala           
    210                 215                 220                           

aaa cac caa cca atg gaa att aat aaa cgt gct ttt gat aat tta ttg        720
Lys His Gln Pro Met Glu Ile Asn Lys Arg Ala Phe Asp Asn Leu Leu           
225                 230                 235                 240           

gga ttt cta gat caa ttt cct gat tat atg att ggt tct aat gca gat        768
Gly Phe Leu Asp Gln Phe Pro Asp Tyr Met Ile Gly Ser Asn Ala Asp           
                245                 250                 255               

tta cca att gta gga ggg tca att ttg act cat gac cat tat caa gct        816
Leu Pro Ile Val Gly Gly Ser Ile Leu Thr His Asp His Tyr Gln Ala           
            260                 265                 270                   

gga cgt tat gaa ttt ccg atg gca aaa gct gaa ctt cga gaa gaa att        864
Gly Arg Tyr Glu Phe Pro Met Ala Lys Ala Glu Leu Arg Glu Glu Ile           
        275                 280                 285                       

aaa ctt caa caa ttt cca gaa gtt tct tgc gga att gtg aat tgg cca        912
Lys Leu Gln Gln Phe Pro Glu Val Ser Cys Gly Ile Val Asn Trp Pro           
    290                 295                 300                           

atg tct gtt cta aga tta tca agt aaa aac caa gta gaa ctt tca aaa        960
Met Ser Val Leu Arg Leu Ser Ser Lys Asn Gln Val Glu Leu Ser Lys           
305                 310                 315                 320           

gct gca gat gaa ctt tta aaa aaa tgg caa gtt tat agt gat gaa agt       1008
Ala Ala Asp Glu Leu Leu Lys Lys Trp Gln Val Tyr Ser Asp Glu Ser           
                325                 330                 335               

ctt caa atc aaa gct aaa agt gct gac gga aag ctt cat cat aca att       1056
Leu Gln Ile Lys Ala Lys Ser Ala Asp Gly Lys Leu His His Thr Ile           
            340                 345                 350                   

act ccg att gct cga att cga gag ggg aaa tat gaa tta gat tta gtt       1104
Thr Pro Ile Ala Arg Ile Arg Glu Gly Lys Tyr Glu Leu Asp Leu Val           
        355                 360                 365                       

tta cga gat aat aat aca agt gaa att tat cca gat gga att ttt cat       1152
Leu Arg Asp Asn Asn Thr Ser Glu Ile Tyr Pro Asp Gly Ile Phe His           
    370                 375                 380                           

cca cat cca gcc tta cac cat att aaa aaa gaa aat att gga ttg att       1200
Pro His Pro Ala Leu His His Ile Lys Lys Glu Asn Ile Gly Leu Ile           
385                 390                 395                 400           

gaa gtg atg gga ctt gca att tta cca gcc agg tta aag aca gaa ctt       1248
Glu Val Met Gly Leu Ala Ile Leu Pro Ala Arg Leu Lys Thr Glu Leu           
                405                 410                 415               

ttg gaa gtt gaa aaa tat ctc ttg aat caa gaa aat gag atg tca gaa       1296
Leu Glu Val Glu Lys Tyr Leu Leu Asn Gln Glu Asn Glu Met Ser Glu           
            420                 425                 430                   

att cac aaa cca tgg gct gaa gaa ttg aaa gaa aca gaa tat ttt tca       1344
Ile His Lys Pro Trp Ala Glu Glu Leu Lys Glu Thr Glu Tyr Phe Ser           
        435                 440                 445                       

aaa gaa aca gtt cat gaa aca gtt cag gaa gca gtt gga gaa gta ttt       1392
Lys Glu Thr Val His Glu Thr Val Gln Glu Ala Val Gly Glu Val Phe           
    450                 455                 460                           

gaa cag gtg tta aaa gat gcc gga gta ttc aaa gat aat gaa gta gga       1440
Glu Gln Val Leu Lys Asp Ala Gly Val Phe Lys Asp Asn Glu Val Gly           
465                 470                 475                 480           

caa aaa ggt ttt tat gaa ttt ata aat ttc gta aat aat taa               1482
Gln Lys Gly Phe Tyr Glu Phe Ile Asn Phe Val Asn Asn                       
                485                 490                                   


<210>  36
<211>  493
<212>  PRT
<213>  Lactococcus lactis subsp. lactis strain UC77

<400>  36

Met Ser Ile Tyr Gln Ser Ile Gln Asp Phe Ile Ser Leu Ala Leu Gln 
1               5                   10                  15      


Asn Gly Thr Ile Glu Pro Leu Asp Glu Leu Tyr His Arg Asn Gln Leu 
            20                  25                  30          


Leu His Phe Leu Gly Leu Asn Asp Trp Ala Glu Val Asp Lys Glu Ala 
        35                  40                  45              


His Glu Lys Asp Ser Leu Ile Leu Met Asp Gln Leu Leu Ala Ile Ala 
    50                  55                  60                  


Asn Glu Asn Asn Val Ile Glu Lys Gly Gln Asp Glu Phe Tyr Glu Ala 
65                  70                  75                  80  


Ala Leu Met Asn Phe Ile Thr Pro Arg Pro Ser Lys Ile Asn Gln Asp 
                85                  90                  95      


Phe Trp Glu Lys Tyr Lys Thr Ser Pro Asp Ala Ala Thr Gln Tyr Phe 
            100                 105                 110         


Tyr Glu Leu Ala Gln Gln Val Asn Gln Val Lys Thr Arg Asp Ile Thr 
        115                 120                 125             


Arg Asn Ile Ala Phe Ser His Leu Thr Lys Tyr Gly Lys Leu Glu Ile 
    130                 135                 140                 


Thr Ile Asn Leu Ser Lys Pro Glu Lys Asp Pro Lys Ala Ile Ala Ala 
145                 150                 155                 160 


Ala Lys Leu Val Lys Ala Ser Ser Tyr Pro Ala Cys Gln Leu Cys Leu 
                165                 170                 175     


Glu Asn Glu Gly Phe Tyr Gly Ile Gly Asn Lys Pro Ala Arg Ser Asn 
            180                 185                 190         


His Arg Ile Ile Gln Val Ser Ile Asn Gly Glu Asp Trp Gly Phe Gln 
        195                 200                 205             


Tyr Ser Pro Tyr Ala Tyr Phe Asn Glu His Ser Ile Leu Leu Asn Ala 
    210                 215                 220                 


Lys His Gln Pro Met Glu Ile Asn Lys Arg Ala Phe Asp Asn Leu Leu 
225                 230                 235                 240 


Gly Phe Leu Asp Gln Phe Pro Asp Tyr Met Ile Gly Ser Asn Ala Asp 
                245                 250                 255     


Leu Pro Ile Val Gly Gly Ser Ile Leu Thr His Asp His Tyr Gln Ala 
            260                 265                 270         


Gly Arg Tyr Glu Phe Pro Met Ala Lys Ala Glu Leu Arg Glu Glu Ile 
        275                 280                 285             


Lys Leu Gln Gln Phe Pro Glu Val Ser Cys Gly Ile Val Asn Trp Pro 
    290                 295                 300                 


Met Ser Val Leu Arg Leu Ser Ser Lys Asn Gln Val Glu Leu Ser Lys 
305                 310                 315                 320 


Ala Ala Asp Glu Leu Leu Lys Lys Trp Gln Val Tyr Ser Asp Glu Ser 
                325                 330                 335     


Leu Gln Ile Lys Ala Lys Ser Ala Asp Gly Lys Leu His His Thr Ile 
            340                 345                 350         


Thr Pro Ile Ala Arg Ile Arg Glu Gly Lys Tyr Glu Leu Asp Leu Val 
        355                 360                 365             


Leu Arg Asp Asn Asn Thr Ser Glu Ile Tyr Pro Asp Gly Ile Phe His 
    370                 375                 380                 


Pro His Pro Ala Leu His His Ile Lys Lys Glu Asn Ile Gly Leu Ile 
385                 390                 395                 400 


Glu Val Met Gly Leu Ala Ile Leu Pro Ala Arg Leu Lys Thr Glu Leu 
                405                 410                 415     


Leu Glu Val Glu Lys Tyr Leu Leu Asn Gln Glu Asn Glu Met Ser Glu 
            420                 425                 430         


Ile His Lys Pro Trp Ala Glu Glu Leu Lys Glu Thr Glu Tyr Phe Ser 
        435                 440                 445             


Lys Glu Thr Val His Glu Thr Val Gln Glu Ala Val Gly Glu Val Phe 
    450                 455                 460                 


Glu Gln Val Leu Lys Asp Ala Gly Val Phe Lys Asp Asn Glu Val Gly 
465                 470                 475                 480 


Gln Lys Gly Phe Tyr Glu Phe Ile Asn Phe Val Asn Asn 
                485                 490             


<210>  37
<211>  981
<212>  DNA
<213>  Lactococcus lactis subsp. cremoris NZ9000


<220>
<221>  CDS
<222>  (1)..(981)
<223>  GalE gene encoding UDP-glucose 4-epimerase

<300>
<308>  GenBank CP002094.1
<309>  2014-01-30
<313>  (2195191)..(2196171)

<400>  37
atg aca gtt tta gta ctt ggt gga gca gga tat gta gga agc cat gcg         48
Met Thr Val Leu Val Leu Gly Gly Ala Gly Tyr Val Gly Ser His Ala           
1               5                   10                  15                

gta gat atg ctt gtt aat cgt ggt tac gat gtg gca gtt gtt gat aat         96
Val Asp Met Leu Val Asn Arg Gly Tyr Asp Val Ala Val Val Asp Asn           
            20                  25                  30                    

tta gta aca ggt cat cgc gag gct gtg tca gaa aaa gta cgt ttt tat        144
Leu Val Thr Gly His Arg Glu Ala Val Ser Glu Lys Val Arg Phe Tyr           
        35                  40                  45                        

gag gga gat gta cgg gac cat gct ttc tta gct agt gtt ttt gaa aag        192
Glu Gly Asp Val Arg Asp His Ala Phe Leu Ala Ser Val Phe Glu Lys           
    50                  55                  60                            

gaa aat att gaa gga att atg cat ttt tgc gct tat tca tta gtg ggt        240
Glu Asn Ile Glu Gly Ile Met His Phe Cys Ala Tyr Ser Leu Val Gly           
65                  70                  75                  80            

gag tca atg caa aaa cca ttg atg tat ttc aat aac aat gtc ggc gga        288
Glu Ser Met Gln Lys Pro Leu Met Tyr Phe Asn Asn Asn Val Gly Gly           
                85                  90                  95                

gct cag gtg att cta gaa aca atg gaa gaa ttt ggt gtt aag cat att        336
Ala Gln Val Ile Leu Glu Thr Met Glu Glu Phe Gly Val Lys His Ile           
            100                 105                 110                   

gtt ttc tca agt acc gca gct act ttt ggt att cct gag gaa agt cca        384
Val Phe Ser Ser Thr Ala Ala Thr Phe Gly Ile Pro Glu Glu Ser Pro           
        115                 120                 125                       

att tct gaa aaa aca cca caa aaa cca att aat cct tac ggc gaa agt        432
Ile Ser Glu Lys Thr Pro Gln Lys Pro Ile Asn Pro Tyr Gly Glu Ser           
    130                 135                 140                           

aaa tta atc atg gaa aaa atg atg aaa tgg caa tcg caa gcc aca gat        480
Lys Leu Ile Met Glu Lys Met Met Lys Trp Gln Ser Gln Ala Thr Asp           
145                 150                 155                 160           

atg act tat gtt gct ctg cgc tat ttc aat gtt gct ggt gcc aaa gat        528
Met Thr Tyr Val Ala Leu Arg Tyr Phe Asn Val Ala Gly Ala Lys Asp           
                165                 170                 175               

gat ggg tca att ggt gaa gcc cat aaa aat gaa aca cat tta att cca        576
Asp Gly Ser Ile Gly Glu Ala His Lys Asn Glu Thr His Leu Ile Pro           
            180                 185                 190                   

att atc cta caa act gca ctt gga caa aga gaa ttt att acc att tat        624
Ile Ile Leu Gln Thr Ala Leu Gly Gln Arg Glu Phe Ile Thr Ile Tyr           
        195                 200                 205                       

ggt gat gat tat cag act cct gat gga aca tgt atc cgt gat tat att        672
Gly Asp Asp Tyr Gln Thr Pro Asp Gly Thr Cys Ile Arg Asp Tyr Ile           
    210                 215                 220                           

gat atg gaa gat ttg att gaa gca cat atc aaa gca ctt gaa tat ctt        720
Asp Met Glu Asp Leu Ile Glu Ala His Ile Lys Ala Leu Glu Tyr Leu           
225                 230                 235                 240           

aaa tct ggt ggg aaa tct gac caa ttt aat ctt ggc tca agt aaa ggt        768
Lys Ser Gly Gly Lys Ser Asp Gln Phe Asn Leu Gly Ser Ser Lys Gly           
                245                 250                 255               

tat tca aat ctt gaa gtg ctt gaa aca gca cga aaa gta aca gga aaa        816
Tyr Ser Asn Leu Glu Val Leu Glu Thr Ala Arg Lys Val Thr Gly Lys           
            260                 265                 270                   

gaa att cca agt caa atg ggt gaa cgt cgt cct ggc gat cca gat gaa        864
Glu Ile Pro Ser Gln Met Gly Glu Arg Arg Pro Gly Asp Pro Asp Glu           
        275                 280                 285                       

ctt gta gcg gac tca aca aaa gcc ggc gaa att tta gga tgg aaa gta        912
Leu Val Ala Asp Ser Thr Lys Ala Gly Glu Ile Leu Gly Trp Lys Val           
    290                 295                 300                           

aaa aat gat ttg gaa cac atc att aca aat gct tgg gaa tgg cat caa        960
Lys Asn Asp Leu Glu His Ile Ile Thr Asn Ala Trp Glu Trp His Gln           
305                 310                 315                 320           

agt cat cca aaa ggc tac tga                                            981
Ser His Pro Lys Gly Tyr                                                   
                325                                                       


<210>  38
<211>  326
<212>  PRT
<213>  Lactococcus lactis subsp. cremoris NZ9000

<400>  38

Met Thr Val Leu Val Leu Gly Gly Ala Gly Tyr Val Gly Ser His Ala 
1               5                   10                  15      


Val Asp Met Leu Val Asn Arg Gly Tyr Asp Val Ala Val Val Asp Asn 
            20                  25                  30          


Leu Val Thr Gly His Arg Glu Ala Val Ser Glu Lys Val Arg Phe Tyr 
        35                  40                  45              


Glu Gly Asp Val Arg Asp His Ala Phe Leu Ala Ser Val Phe Glu Lys 
    50                  55                  60                  


Glu Asn Ile Glu Gly Ile Met His Phe Cys Ala Tyr Ser Leu Val Gly 
65                  70                  75                  80  


Glu Ser Met Gln Lys Pro Leu Met Tyr Phe Asn Asn Asn Val Gly Gly 
                85                  90                  95      


Ala Gln Val Ile Leu Glu Thr Met Glu Glu Phe Gly Val Lys His Ile 
            100                 105                 110         


Val Phe Ser Ser Thr Ala Ala Thr Phe Gly Ile Pro Glu Glu Ser Pro 
        115                 120                 125             


Ile Ser Glu Lys Thr Pro Gln Lys Pro Ile Asn Pro Tyr Gly Glu Ser 
    130                 135                 140                 


Lys Leu Ile Met Glu Lys Met Met Lys Trp Gln Ser Gln Ala Thr Asp 
145                 150                 155                 160 


Met Thr Tyr Val Ala Leu Arg Tyr Phe Asn Val Ala Gly Ala Lys Asp 
                165                 170                 175     


Asp Gly Ser Ile Gly Glu Ala His Lys Asn Glu Thr His Leu Ile Pro 
            180                 185                 190         


Ile Ile Leu Gln Thr Ala Leu Gly Gln Arg Glu Phe Ile Thr Ile Tyr 
        195                 200                 205             


Gly Asp Asp Tyr Gln Thr Pro Asp Gly Thr Cys Ile Arg Asp Tyr Ile 
    210                 215                 220                 


Asp Met Glu Asp Leu Ile Glu Ala His Ile Lys Ala Leu Glu Tyr Leu 
225                 230                 235                 240 


Lys Ser Gly Gly Lys Ser Asp Gln Phe Asn Leu Gly Ser Ser Lys Gly 
                245                 250                 255     


Tyr Ser Asn Leu Glu Val Leu Glu Thr Ala Arg Lys Val Thr Gly Lys 
            260                 265                 270         


Glu Ile Pro Ser Gln Met Gly Glu Arg Arg Pro Gly Asp Pro Asp Glu 
        275                 280                 285             


Leu Val Ala Asp Ser Thr Lys Ala Gly Glu Ile Leu Gly Trp Lys Val 
    290                 295                 300                 


Lys Asn Asp Leu Glu His Ile Ile Thr Asn Ala Trp Glu Trp His Gln 
305                 310                 315                 320 


Ser His Pro Lys Gly Tyr 
                325     


<210>  39
<211>  981
<212>  DNA
<213>  Lactococcus lactis strain AI06


<220>
<221>  CDS
<222>  (1)..(981)
<223>  galE gene encoding UDP-glucose 4-epimerase

<300>
<308>  GenBank CP009472.1
<309>  2014-12-10
<313>  (2097681)..(2098661)

<400>  39
atg acg gtt tta gtt ctt ggt gga gca gga tat gtg gga agc cat gcg         48
Met Thr Val Leu Val Leu Gly Gly Ala Gly Tyr Val Gly Ser His Ala           
1               5                   10                  15                

gta gat atg ctt ctt aaa cgt ggt tac gat gtg gca gtg gtg gat aat         96
Val Asp Met Leu Leu Lys Arg Gly Tyr Asp Val Ala Val Val Asp Asn           
            20                  25                  30                    

tta gtg aca gga cac cgt gaa tct gtt cca gca aat gta cgc ttt tac        144
Leu Val Thr Gly His Arg Glu Ser Val Pro Ala Asn Val Arg Phe Tyr           
        35                  40                  45                        

gag ggt gat gtg cgt gat cat gct ttc tta gct agt gtt ttt gaa aaa        192
Glu Gly Asp Val Arg Asp His Ala Phe Leu Ala Ser Val Phe Glu Lys           
    50                  55                  60                            

gaa aat att gaa gga atc atg cat ttt tgt gct tac tct tta gtg ggt        240
Glu Asn Ile Glu Gly Ile Met His Phe Cys Ala Tyr Ser Leu Val Gly           
65                  70                  75                  80            

gag tca atg caa aaa cct tta atg tat ttt aat aat aat gtc ggt ggt        288
Glu Ser Met Gln Lys Pro Leu Met Tyr Phe Asn Asn Asn Val Gly Gly           
                85                  90                  95                

gct caa gta att cta gaa acg atg gaa gaa ttc gga gta aaa cat att        336
Ala Gln Val Ile Leu Glu Thr Met Glu Glu Phe Gly Val Lys His Ile           
            100                 105                 110                   

gtt ttc tca agt aca gca gct aca ttt gga att cca gaa aaa agt cca        384
Val Phe Ser Ser Thr Ala Ala Thr Phe Gly Ile Pro Glu Lys Ser Pro           
        115                 120                 125                       

att tca gaa aaa aca cct caa aaa cca att aac cct tat ggt gaa agc        432
Ile Ser Glu Lys Thr Pro Gln Lys Pro Ile Asn Pro Tyr Gly Glu Ser           
    130                 135                 140                           

aaa tta atc atg gaa aaa atg atg aaa tgg caa tcg caa gca act gat        480
Lys Leu Ile Met Glu Lys Met Met Lys Trp Gln Ser Gln Ala Thr Asp           
145                 150                 155                 160           

atg act tat gtt gct ttg cgt tat ttc aat gtt gct ggg gct aaa gat        528
Met Thr Tyr Val Ala Leu Arg Tyr Phe Asn Val Ala Gly Ala Lys Asp           
                165                 170                 175               

gat ggt tca att ggt gaa gct cat aaa aat gaa aca cac ttg att cca        576
Asp Gly Ser Ile Gly Glu Ala His Lys Asn Glu Thr His Leu Ile Pro           
            180                 185                 190                   

att att tta caa aca gca ctt ggt caa agg gaa ttg att act att tat        624
Ile Ile Leu Gln Thr Ala Leu Gly Gln Arg Glu Leu Ile Thr Ile Tyr           
        195                 200                 205                       

ggt gat gac tat cac acg cct gat gga act tgt att cgt gat tat att        672
Gly Asp Asp Tyr His Thr Pro Asp Gly Thr Cys Ile Arg Asp Tyr Ile           
    210                 215                 220                           

gat atg gaa gat ttg att gaa gca cac atc aaa gca ctg gag tat ctt        720
Asp Met Glu Asp Leu Ile Glu Ala His Ile Lys Ala Leu Glu Tyr Leu           
225                 230                 235                 240           

aaa tcc ggt ggt cag tct gac caa ttt aat ctc ggt tta agt aag ggt        768
Lys Ser Gly Gly Gln Ser Asp Gln Phe Asn Leu Gly Leu Ser Lys Gly           
                245                 250                 255               

tat tca aat ctt gaa gtg ctt gaa acc gca cga aaa gta aca ggt aaa        816
Tyr Ser Asn Leu Glu Val Leu Glu Thr Ala Arg Lys Val Thr Gly Lys           
            260                 265                 270                   

gaa att cca agc caa atg ggt gaa cgt cgt gcg gga gac cca gat gaa        864
Glu Ile Pro Ser Gln Met Gly Glu Arg Arg Ala Gly Asp Pro Asp Glu           
        275                 280                 285                       

ctc gta gca gat tca aca aaa gct ggt gaa att ttg ggt tgg aaa gca        912
Leu Val Ala Asp Ser Thr Lys Ala Gly Glu Ile Leu Gly Trp Lys Ala           
    290                 295                 300                           

caa aat gat tta gag cac att att acg aac gct tgg aaa tgg cac caa        960
Gln Asn Asp Leu Glu His Ile Ile Thr Asn Ala Trp Lys Trp His Gln           
305                 310                 315                 320           

agt cat ccg aaa ggt tat tga                                            981
Ser His Pro Lys Gly Tyr                                                   
                325                                                       


<210>  40
<211>  326
<212>  PRT
<213>  Lactococcus lactis strain AI06

<400>  40

Met Thr Val Leu Val Leu Gly Gly Ala Gly Tyr Val Gly Ser His Ala 
1               5                   10                  15      


Val Asp Met Leu Leu Lys Arg Gly Tyr Asp Val Ala Val Val Asp Asn 
            20                  25                  30          


Leu Val Thr Gly His Arg Glu Ser Val Pro Ala Asn Val Arg Phe Tyr 
        35                  40                  45              


Glu Gly Asp Val Arg Asp His Ala Phe Leu Ala Ser Val Phe Glu Lys 
    50                  55                  60                  


Glu Asn Ile Glu Gly Ile Met His Phe Cys Ala Tyr Ser Leu Val Gly 
65                  70                  75                  80  


Glu Ser Met Gln Lys Pro Leu Met Tyr Phe Asn Asn Asn Val Gly Gly 
                85                  90                  95      


Ala Gln Val Ile Leu Glu Thr Met Glu Glu Phe Gly Val Lys His Ile 
            100                 105                 110         


Val Phe Ser Ser Thr Ala Ala Thr Phe Gly Ile Pro Glu Lys Ser Pro 
        115                 120                 125             


Ile Ser Glu Lys Thr Pro Gln Lys Pro Ile Asn Pro Tyr Gly Glu Ser 
    130                 135                 140                 


Lys Leu Ile Met Glu Lys Met Met Lys Trp Gln Ser Gln Ala Thr Asp 
145                 150                 155                 160 


Met Thr Tyr Val Ala Leu Arg Tyr Phe Asn Val Ala Gly Ala Lys Asp 
                165                 170                 175     


Asp Gly Ser Ile Gly Glu Ala His Lys Asn Glu Thr His Leu Ile Pro 
            180                 185                 190         


Ile Ile Leu Gln Thr Ala Leu Gly Gln Arg Glu Leu Ile Thr Ile Tyr 
        195                 200                 205             


Gly Asp Asp Tyr His Thr Pro Asp Gly Thr Cys Ile Arg Asp Tyr Ile 
    210                 215                 220                 


Asp Met Glu Asp Leu Ile Glu Ala His Ile Lys Ala Leu Glu Tyr Leu 
225                 230                 235                 240 


Lys Ser Gly Gly Gln Ser Asp Gln Phe Asn Leu Gly Leu Ser Lys Gly 
                245                 250                 255     


Tyr Ser Asn Leu Glu Val Leu Glu Thr Ala Arg Lys Val Thr Gly Lys 
            260                 265                 270         


Glu Ile Pro Ser Gln Met Gly Glu Arg Arg Ala Gly Asp Pro Asp Glu 
        275                 280                 285             


Leu Val Ala Asp Ser Thr Lys Ala Gly Glu Ile Leu Gly Trp Lys Ala 
    290                 295                 300                 


Gln Asn Asp Leu Glu His Ile Ile Thr Asn Ala Trp Lys Trp His Gln 
305                 310                 315                 320 


Ser His Pro Lys Gly Tyr 
                325     


<210>  41
<211>  984
<212>  DNA
<213>  Lactococcus garvieae Lg2


<220>
<221>  CDS
<222>  (1)..(984)
<223>  galE gene encoding UDP-glucose 4-epimerase

<300>
<308>  GenBank AP009333.1
<309>  2016-10-07
<313>  (1691853)..(1692836)

<400>  41
atg aca gtc tta gta ctt gga ggc gca ggc tat gta gga agc cat gct         48
Met Thr Val Leu Val Leu Gly Gly Ala Gly Tyr Val Gly Ser His Ala           
1               5                   10                  15                

gtt gat att cta gtg gca cgt ggt tat gat gtg gcc gtt gta gat aat         96
Val Asp Ile Leu Val Ala Arg Gly Tyr Asp Val Ala Val Val Asp Asn           
            20                  25                  30                    

ctt gtg aca gga cat cga gaa gct gtc cca gca gat gta cgc ttc tat        144
Leu Val Thr Gly His Arg Glu Ala Val Pro Ala Asp Val Arg Phe Tyr           
        35                  40                  45                        

gaa gga gat gtg cgc gat caa gct ttt ttg gct gat gtt ttt aca aaa        192
Glu Gly Asp Val Arg Asp Gln Ala Phe Leu Ala Asp Val Phe Thr Lys           
    50                  55                  60                            

gaa aaa gat att gaa ggc tta atg cat ttt tgt gcc tat tct ttg gtg        240
Glu Lys Asp Ile Glu Gly Leu Met His Phe Cys Ala Tyr Ser Leu Val           
65                  70                  75                  80            

ggt gaa tca atg caa aaa cca ctg atg tat ttt aat aat aac gtt ggt        288
Gly Glu Ser Met Gln Lys Pro Leu Met Tyr Phe Asn Asn Asn Val Gly           
                85                  90                  95                

ggg gca cag gtt atc ctt gaa acc atg gaa aaa ttt ggt atc aag cat        336
Gly Ala Gln Val Ile Leu Glu Thr Met Glu Lys Phe Gly Ile Lys His           
            100                 105                 110                   

att gtc ttt tca agt acg gct gca act ttt ggg ata cca gaa gaa agt        384
Ile Val Phe Ser Ser Thr Ala Ala Thr Phe Gly Ile Pro Glu Glu Ser           
        115                 120                 125                       

cct att tct gaa aaa act cca caa aaa cca att aat cct tac ggg gaa        432
Pro Ile Ser Glu Lys Thr Pro Gln Lys Pro Ile Asn Pro Tyr Gly Glu           
    130                 135                 140                           

agc aaa ctc atc atg gaa aaa atg atg aag tgg caa tca gag gca act        480
Ser Lys Leu Ile Met Glu Lys Met Met Lys Trp Gln Ser Glu Ala Thr           
145                 150                 155                 160           

gat atg act tat gtg gcc ctg cgc tac ttc aat gtt gca ggt gcg aaa        528
Asp Met Thr Tyr Val Ala Leu Arg Tyr Phe Asn Val Ala Gly Ala Lys           
                165                 170                 175               

cat gat ggc agt att ggt gag gca cat aaa aat gaa aca cat ctg att        576
His Asp Gly Ser Ile Gly Glu Ala His Lys Asn Glu Thr His Leu Ile           
            180                 185                 190                   

cca ctc att tta caa acg gct tta gga caa cgt gag ttt atc act atc        624
Pro Leu Ile Leu Gln Thr Ala Leu Gly Gln Arg Glu Phe Ile Thr Ile           
        195                 200                 205                       

tat ggg gat gac tac aat acc cct gac ggt aca tgt gta cgt gac tat        672
Tyr Gly Asp Asp Tyr Asn Thr Pro Asp Gly Thr Cys Val Arg Asp Tyr           
    210                 215                 220                           

att gac atg gaa gat ttg att gaa gca cat atc aaa gcc tta gaa tat        720
Ile Asp Met Glu Asp Leu Ile Glu Ala His Ile Lys Ala Leu Glu Tyr           
225                 230                 235                 240           

ctt aaa gca ggc ggt gct tcg gac cag ttt aac ctt ggc tct tca aaa        768
Leu Lys Ala Gly Gly Ala Ser Asp Gln Phe Asn Leu Gly Ser Ser Lys           
                245                 250                 255               

ggc tac tct aac ctt gaa gtc ttg gaa act gca cgc cgt gtt acc ggt        816
Gly Tyr Ser Asn Leu Glu Val Leu Glu Thr Ala Arg Arg Val Thr Gly           
            260                 265                 270                   

aaa gaa att cca tca caa atg gga gaa cgt cgc cct ggt gac cca gat        864
Lys Glu Ile Pro Ser Gln Met Gly Glu Arg Arg Pro Gly Asp Pro Asp           
        275                 280                 285                       

atg ctt gtt gca gac tcg acg aaa gct gga gaa atc ttg gat tgg cac        912
Met Leu Val Ala Asp Ser Thr Lys Ala Gly Glu Ile Leu Asp Trp His           
    290                 295                 300                           

gtg aag aat aat tta gaa tat att atc gag aat gct tgg aaa tgg cat        960
Val Lys Asn Asn Leu Glu Tyr Ile Ile Glu Asn Ala Trp Lys Trp His           
305                 310                 315                 320           

agc tct cat cca aat gga tat taa                                        984
Ser Ser His Pro Asn Gly Tyr                                               
                325                                                       


<210>  42
<211>  327
<212>  PRT
<213>  Lactococcus garvieae Lg2

<400>  42

Met Thr Val Leu Val Leu Gly Gly Ala Gly Tyr Val Gly Ser His Ala 
1               5                   10                  15      


Val Asp Ile Leu Val Ala Arg Gly Tyr Asp Val Ala Val Val Asp Asn 
            20                  25                  30          


Leu Val Thr Gly His Arg Glu Ala Val Pro Ala Asp Val Arg Phe Tyr 
        35                  40                  45              


Glu Gly Asp Val Arg Asp Gln Ala Phe Leu Ala Asp Val Phe Thr Lys 
    50                  55                  60                  


Glu Lys Asp Ile Glu Gly Leu Met His Phe Cys Ala Tyr Ser Leu Val 
65                  70                  75                  80  


Gly Glu Ser Met Gln Lys Pro Leu Met Tyr Phe Asn Asn Asn Val Gly 
                85                  90                  95      


Gly Ala Gln Val Ile Leu Glu Thr Met Glu Lys Phe Gly Ile Lys His 
            100                 105                 110         


Ile Val Phe Ser Ser Thr Ala Ala Thr Phe Gly Ile Pro Glu Glu Ser 
        115                 120                 125             


Pro Ile Ser Glu Lys Thr Pro Gln Lys Pro Ile Asn Pro Tyr Gly Glu 
    130                 135                 140                 


Ser Lys Leu Ile Met Glu Lys Met Met Lys Trp Gln Ser Glu Ala Thr 
145                 150                 155                 160 


Asp Met Thr Tyr Val Ala Leu Arg Tyr Phe Asn Val Ala Gly Ala Lys 
                165                 170                 175     


His Asp Gly Ser Ile Gly Glu Ala His Lys Asn Glu Thr His Leu Ile 
            180                 185                 190         


Pro Leu Ile Leu Gln Thr Ala Leu Gly Gln Arg Glu Phe Ile Thr Ile 
        195                 200                 205             


Tyr Gly Asp Asp Tyr Asn Thr Pro Asp Gly Thr Cys Val Arg Asp Tyr 
    210                 215                 220                 


Ile Asp Met Glu Asp Leu Ile Glu Ala His Ile Lys Ala Leu Glu Tyr 
225                 230                 235                 240 


Leu Lys Ala Gly Gly Ala Ser Asp Gln Phe Asn Leu Gly Ser Ser Lys 
                245                 250                 255     


Gly Tyr Ser Asn Leu Glu Val Leu Glu Thr Ala Arg Arg Val Thr Gly 
            260                 265                 270         


Lys Glu Ile Pro Ser Gln Met Gly Glu Arg Arg Pro Gly Asp Pro Asp 
        275                 280                 285             


Met Leu Val Ala Asp Ser Thr Lys Ala Gly Glu Ile Leu Asp Trp His 
    290                 295                 300                 


Val Lys Asn Asn Leu Glu Tyr Ile Ile Glu Asn Ala Trp Lys Trp His 
305                 310                 315                 320 


Ser Ser His Pro Asn Gly Tyr 
                325         


<210>  43
<211>  1188
<212>  DNA
<213>  Synthetic


<220>
<221>  CDS
<222>  (1)..(1188)
<223>  codon optimised xylA gene encoding xylose isomerase (originating 
       from Arthrobacter sp.)

<400>  43
atg tcc gtg cag cca acc cca gct gat cac ttc acc ttc ggc ctg tgg         48
Met Ser Val Gln Pro Thr Pro Ala Asp His Phe Thr Phe Gly Leu Trp           
1               5                   10                  15                

acc gtg ggt tgg acc ggt gct gat cca ttc ggc gtc gca acc cgc aag         96
Thr Val Gly Trp Thr Gly Ala Asp Pro Phe Gly Val Ala Thr Arg Lys           
            20                  25                  30                    

aac ctc gac cca gtg gag gca gtc cac aag ctc gca gaa ctg ggc gcc        144
Asn Leu Asp Pro Val Glu Ala Val His Lys Leu Ala Glu Leu Gly Ala           
        35                  40                  45                        

tac ggc atc acc ttc cac gat aac gac ctg atc cca ttc gat gct acc        192
Tyr Gly Ile Thr Phe His Asp Asn Asp Leu Ile Pro Phe Asp Ala Thr           
    50                  55                  60                            

gaa gca gag cgc gaa aag atc ctc ggc gat ttc aac cag gcc ctc aag        240
Glu Ala Glu Arg Glu Lys Ile Leu Gly Asp Phe Asn Gln Ala Leu Lys           
65                  70                  75                  80            

gac acc ggc ctg aag gtg cca atg gtc acc acc aac ctg ttc tcc cac        288
Asp Thr Gly Leu Lys Val Pro Met Val Thr Thr Asn Leu Phe Ser His           
                85                  90                  95                

cca gtg ttc aag gat ggt ggc ttc acc tcc aac gac cgc tcc atc cgt        336
Pro Val Phe Lys Asp Gly Gly Phe Thr Ser Asn Asp Arg Ser Ile Arg           
            100                 105                 110                   

cgc ttc gca ctc gcc aag gtg ctg cac aac atc gat ctc gca gcc gag        384
Arg Phe Ala Leu Ala Lys Val Leu His Asn Ile Asp Leu Ala Ala Glu           
        115                 120                 125                       

atg ggc gca gaa acc ttc gtc atg tgg ggc ggc cgt gag ggt tcc gaa        432
Met Gly Ala Glu Thr Phe Val Met Trp Gly Gly Arg Glu Gly Ser Glu           
    130                 135                 140                           

tac gat ggc tcc aag gac ctc gca gca gca ctg gat cgc atg cgc gaa        480
Tyr Asp Gly Ser Lys Asp Leu Ala Ala Ala Leu Asp Arg Met Arg Glu           
145                 150                 155                 160           

ggc gtc gac acc gca gca ggc tac atc aag gat aag ggc tac aac ctc        528
Gly Val Asp Thr Ala Ala Gly Tyr Ile Lys Asp Lys Gly Tyr Asn Leu           
                165                 170                 175               

cgc atc gca ctg gag cca aag cca aac gaa cca cgc ggc gac atc ttc        576
Arg Ile Ala Leu Glu Pro Lys Pro Asn Glu Pro Arg Gly Asp Ile Phe           
            180                 185                 190                   

ctg cca acc gtg ggt cac ggc ctg gca ttc atc gag cag ctc gaa cac        624
Leu Pro Thr Val Gly His Gly Leu Ala Phe Ile Glu Gln Leu Glu His           
        195                 200                 205                       

ggc gat atc gtc ggc ctg aac cca gaa acc ggc cac gaa cag atg gct        672
Gly Asp Ile Val Gly Leu Asn Pro Glu Thr Gly His Glu Gln Met Ala           
    210                 215                 220                           

ggc ctc aac ttc acc cac ggc atc gct cag gca ctc tgg gca gag aag        720
Gly Leu Asn Phe Thr His Gly Ile Ala Gln Ala Leu Trp Ala Glu Lys           
225                 230                 235                 240           

ctg ttc cac atc gac ctc aac ggc cag cgc ggc atc aag tac gat cag        768
Leu Phe His Ile Asp Leu Asn Gly Gln Arg Gly Ile Lys Tyr Asp Gln           
                245                 250                 255               

gac ctg gtg ttc ggc cac ggc gat ctc acc tcc gca ttc ttc acc gtc        816
Asp Leu Val Phe Gly His Gly Asp Leu Thr Ser Ala Phe Phe Thr Val           
            260                 265                 270                   

gac ctg ctc gaa aac ggc ttc cca aac ggt ggc cca aag tac acc ggc        864
Asp Leu Leu Glu Asn Gly Phe Pro Asn Gly Gly Pro Lys Tyr Thr Gly           
        275                 280                 285                       

cca cgc cac ttc gat tac aag cca tcc cgc acc gat ggt tac gat ggt        912
Pro Arg His Phe Asp Tyr Lys Pro Ser Arg Thr Asp Gly Tyr Asp Gly           
    290                 295                 300                           

gtg tgg gac tcc gcc aag gct aac atg tcc atg tac ctg ctg ttg aag        960
Val Trp Asp Ser Ala Lys Ala Asn Met Ser Met Tyr Leu Leu Leu Lys           
305                 310                 315                 320           

gag cgt gca ctg gca ttc cgt gct gat cca gag gtg cag gaa gct atg       1008
Glu Arg Ala Leu Ala Phe Arg Ala Asp Pro Glu Val Gln Glu Ala Met           
                325                 330                 335               

aag acc tcc ggc gtc ttc gag ctg ggc gaa acc acc ctc aac gct ggt       1056
Lys Thr Ser Gly Val Phe Glu Leu Gly Glu Thr Thr Leu Asn Ala Gly           
            340                 345                 350                   

gaa tcc gcc gct gat ctg atg aac gac tcc gcc tcc ttc gct ggc ttc       1104
Glu Ser Ala Ala Asp Leu Met Asn Asp Ser Ala Ser Phe Ala Gly Phe           
        355                 360                 365                       

gac gct gag gca gcc gct gaa cgc aac ttc gca ttc atc cgc ctc aac       1152
Asp Ala Glu Ala Ala Ala Glu Arg Asn Phe Ala Phe Ile Arg Leu Asn           
    370                 375                 380                           

cag ctg gcc atc gaa cac ctc ctg ggc tcc cgc taa                       1188
Gln Leu Ala Ile Glu His Leu Leu Gly Ser Arg                               
385                 390                 395                               


<210>  44
<211>  395
<212>  PRT
<213>  Synthetic

<400>  44

Met Ser Val Gln Pro Thr Pro Ala Asp His Phe Thr Phe Gly Leu Trp 
1               5                   10                  15      


Thr Val Gly Trp Thr Gly Ala Asp Pro Phe Gly Val Ala Thr Arg Lys 
            20                  25                  30          


Asn Leu Asp Pro Val Glu Ala Val His Lys Leu Ala Glu Leu Gly Ala 
        35                  40                  45              


Tyr Gly Ile Thr Phe His Asp Asn Asp Leu Ile Pro Phe Asp Ala Thr 
    50                  55                  60                  


Glu Ala Glu Arg Glu Lys Ile Leu Gly Asp Phe Asn Gln Ala Leu Lys 
65                  70                  75                  80  


Asp Thr Gly Leu Lys Val Pro Met Val Thr Thr Asn Leu Phe Ser His 
                85                  90                  95      


Pro Val Phe Lys Asp Gly Gly Phe Thr Ser Asn Asp Arg Ser Ile Arg 
            100                 105                 110         


Arg Phe Ala Leu Ala Lys Val Leu His Asn Ile Asp Leu Ala Ala Glu 
        115                 120                 125             


Met Gly Ala Glu Thr Phe Val Met Trp Gly Gly Arg Glu Gly Ser Glu 
    130                 135                 140                 


Tyr Asp Gly Ser Lys Asp Leu Ala Ala Ala Leu Asp Arg Met Arg Glu 
145                 150                 155                 160 


Gly Val Asp Thr Ala Ala Gly Tyr Ile Lys Asp Lys Gly Tyr Asn Leu 
                165                 170                 175     


Arg Ile Ala Leu Glu Pro Lys Pro Asn Glu Pro Arg Gly Asp Ile Phe 
            180                 185                 190         


Leu Pro Thr Val Gly His Gly Leu Ala Phe Ile Glu Gln Leu Glu His 
        195                 200                 205             


Gly Asp Ile Val Gly Leu Asn Pro Glu Thr Gly His Glu Gln Met Ala 
    210                 215                 220                 


Gly Leu Asn Phe Thr His Gly Ile Ala Gln Ala Leu Trp Ala Glu Lys 
225                 230                 235                 240 


Leu Phe His Ile Asp Leu Asn Gly Gln Arg Gly Ile Lys Tyr Asp Gln 
                245                 250                 255     


Asp Leu Val Phe Gly His Gly Asp Leu Thr Ser Ala Phe Phe Thr Val 
            260                 265                 270         


Asp Leu Leu Glu Asn Gly Phe Pro Asn Gly Gly Pro Lys Tyr Thr Gly 
        275                 280                 285             


Pro Arg His Phe Asp Tyr Lys Pro Ser Arg Thr Asp Gly Tyr Asp Gly 
    290                 295                 300                 


Val Trp Asp Ser Ala Lys Ala Asn Met Ser Met Tyr Leu Leu Leu Lys 
305                 310                 315                 320 


Glu Arg Ala Leu Ala Phe Arg Ala Asp Pro Glu Val Gln Glu Ala Met 
                325                 330                 335     


Lys Thr Ser Gly Val Phe Glu Leu Gly Glu Thr Thr Leu Asn Ala Gly 
            340                 345                 350         


Glu Ser Ala Ala Asp Leu Met Asn Asp Ser Ala Ser Phe Ala Gly Phe 
        355                 360                 365             


Asp Ala Glu Ala Ala Ala Glu Arg Asn Phe Ala Phe Ile Arg Leu Asn 
    370                 375                 380                 


Gln Leu Ala Ile Glu His Leu Leu Gly Ser Arg 
385                 390                 395 


<210>  45
<211>  1188
<212>  DNA
<213>  Arthrobacter Sp. N.R.R.L. B3728


<220>
<221>  CDS
<222>  (1)..(1188)
<223>  xylA gene encoding D-xylose isomerase

<300>
<308>  GenBank X59466.1
<309>  2016-07-26
<313>  (396)..(1578)

<400>  45
atg agc gtt cag ccg acc cct gca gac cac ttc acc ttt ggc ctc tgg         48
Met Ser Val Gln Pro Thr Pro Ala Asp His Phe Thr Phe Gly Leu Trp           
1               5                   10                  15                

acc gta gga tgg acc ggc gcc gac cca ttc ggt gtc gcc acc cgc aag         96
Thr Val Gly Trp Thr Gly Ala Asp Pro Phe Gly Val Ala Thr Arg Lys           
            20                  25                  30                    

aac ctg gac ccg gta gaa gcc gtc cac aag ctg gcc gag ctc ggc gcc        144
Asn Leu Asp Pro Val Glu Ala Val His Lys Leu Ala Glu Leu Gly Ala           
        35                  40                  45                        

tac ggc atc acc ttc cac gac aat gac ctg att cct ttt gac gcc acc        192
Tyr Gly Ile Thr Phe His Asp Asn Asp Leu Ile Pro Phe Asp Ala Thr           
    50                  55                  60                            

gag gca gag cgc gaa aag atc ctt ggt gac ttc aac cag gcg ctg aag        240
Glu Ala Glu Arg Glu Lys Ile Leu Gly Asp Phe Asn Gln Ala Leu Lys           
65                  70                  75                  80            

gac acc ggc ctg aag gtc cca atg gtg acc acc aac ctg ttc agc cac        288
Asp Thr Gly Leu Lys Val Pro Met Val Thr Thr Asn Leu Phe Ser His           
                85                  90                  95                

ccg gtc ttc aag gac ggc ggc ttc acc tct aac gac cgc tcg atc cgt        336
Pro Val Phe Lys Asp Gly Gly Phe Thr Ser Asn Asp Arg Ser Ile Arg           
            100                 105                 110                   

cgt ttt gca ctg gct aag gtc ctg cac aac atc gac ttg gca gcc gag        384
Arg Phe Ala Leu Ala Lys Val Leu His Asn Ile Asp Leu Ala Ala Glu           
        115                 120                 125                       

atg ggc gcc gaa acc ttc gtc atg tgg ggc ggg cgc gaa ggc agc gaa        432
Met Gly Ala Glu Thr Phe Val Met Trp Gly Gly Arg Glu Gly Ser Glu           
    130                 135                 140                           

tac gac ggt tcc aag gac ctg gcc gca gca ctt gat cgc atg cgc gaa        480
Tyr Asp Gly Ser Lys Asp Leu Ala Ala Ala Leu Asp Arg Met Arg Glu           
145                 150                 155                 160           

ggc gtg gac acg gca gct ggc tac atc aag gac aag ggt tac aac ctg        528
Gly Val Asp Thr Ala Ala Gly Tyr Ile Lys Asp Lys Gly Tyr Asn Leu           
                165                 170                 175               

cgc atc gcg ctg gag cca aag cca aat gaa cca cgc ggc gac atc ttc        576
Arg Ile Ala Leu Glu Pro Lys Pro Asn Glu Pro Arg Gly Asp Ile Phe           
            180                 185                 190                   

ctg cct acc gtc ggc cac ggc ctg gcc ttc atc gag cag ctg gag cac        624
Leu Pro Thr Val Gly His Gly Leu Ala Phe Ile Glu Gln Leu Glu His           
        195                 200                 205                       

ggc gac atc gtc ggc ctg aac cca gaa acc ggc cac gag cag atg gcc        672
Gly Asp Ile Val Gly Leu Asn Pro Glu Thr Gly His Glu Gln Met Ala           
    210                 215                 220                           

ggc ctg aac ttc acc cac ggc atc gct cag gca ctg tgg gcc gag aag        720
Gly Leu Asn Phe Thr His Gly Ile Ala Gln Ala Leu Trp Ala Glu Lys           
225                 230                 235                 240           

ctg ttc cac att gac ctc aac ggc cag cgc ggc atc aag tac gac cag        768
Leu Phe His Ile Asp Leu Asn Gly Gln Arg Gly Ile Lys Tyr Asp Gln           
                245                 250                 255               

gac ctg gtc ttc ggc cac ggc gat ctg acc agc gcg ttc ttc acc gta        816
Asp Leu Val Phe Gly His Gly Asp Leu Thr Ser Ala Phe Phe Thr Val           
            260                 265                 270                   

gac ctg ctg gaa aac ggc ttc cct aac ggc gga cca aag tac acc ggc        864
Asp Leu Leu Glu Asn Gly Phe Pro Asn Gly Gly Pro Lys Tyr Thr Gly           
        275                 280                 285                       

cca cgc cac ttc gac tac aag cca tcg cgc acc gac ggc tac gac ggc        912
Pro Arg His Phe Asp Tyr Lys Pro Ser Arg Thr Asp Gly Tyr Asp Gly           
    290                 295                 300                           

gtg tgg gac tcg gcc aag gcc aac atg tcc atg tac ctg ctg ctc aag        960
Val Trp Asp Ser Ala Lys Ala Asn Met Ser Met Tyr Leu Leu Leu Lys           
305                 310                 315                 320           

gaa cgt gcc ctg gcc ttc cgt gcg gat cca gag gta cag gaa gcc atg       1008
Glu Arg Ala Leu Ala Phe Arg Ala Asp Pro Glu Val Gln Glu Ala Met           
                325                 330                 335               

aag acc tcg ggc gtc ttc gaa ctg ggc gaa acc acc ctg aac gcc ggg       1056
Lys Thr Ser Gly Val Phe Glu Leu Gly Glu Thr Thr Leu Asn Ala Gly           
            340                 345                 350                   

gaa agc gca gcg gat ctg atg aat gat tcc gcg agc ttc gca ggc ttt       1104
Glu Ser Ala Ala Asp Leu Met Asn Asp Ser Ala Ser Phe Ala Gly Phe           
        355                 360                 365                       

gac gcc gag gcc gcc gca gag cgc aac ttc gcg ttc atc cgc ctg aac       1152
Asp Ala Glu Ala Ala Ala Glu Arg Asn Phe Ala Phe Ile Arg Leu Asn           
    370                 375                 380                           

cag ctg gcc atc gag cac ctg ctc ggc tcc cgc taa                       1188
Gln Leu Ala Ile Glu His Leu Leu Gly Ser Arg                               
385                 390                 395                               


<210>  46
<211>  395
<212>  PRT
<213>  Arthrobacter Sp. N.R.R.L. B3728

<400>  46

Met Ser Val Gln Pro Thr Pro Ala Asp His Phe Thr Phe Gly Leu Trp 
1               5                   10                  15      


Thr Val Gly Trp Thr Gly Ala Asp Pro Phe Gly Val Ala Thr Arg Lys 
            20                  25                  30          


Asn Leu Asp Pro Val Glu Ala Val His Lys Leu Ala Glu Leu Gly Ala 
        35                  40                  45              


Tyr Gly Ile Thr Phe His Asp Asn Asp Leu Ile Pro Phe Asp Ala Thr 
    50                  55                  60                  


Glu Ala Glu Arg Glu Lys Ile Leu Gly Asp Phe Asn Gln Ala Leu Lys 
65                  70                  75                  80  


Asp Thr Gly Leu Lys Val Pro Met Val Thr Thr Asn Leu Phe Ser His 
                85                  90                  95      


Pro Val Phe Lys Asp Gly Gly Phe Thr Ser Asn Asp Arg Ser Ile Arg 
            100                 105                 110         


Arg Phe Ala Leu Ala Lys Val Leu His Asn Ile Asp Leu Ala Ala Glu 
        115                 120                 125             


Met Gly Ala Glu Thr Phe Val Met Trp Gly Gly Arg Glu Gly Ser Glu 
    130                 135                 140                 


Tyr Asp Gly Ser Lys Asp Leu Ala Ala Ala Leu Asp Arg Met Arg Glu 
145                 150                 155                 160 


Gly Val Asp Thr Ala Ala Gly Tyr Ile Lys Asp Lys Gly Tyr Asn Leu 
                165                 170                 175     


Arg Ile Ala Leu Glu Pro Lys Pro Asn Glu Pro Arg Gly Asp Ile Phe 
            180                 185                 190         


Leu Pro Thr Val Gly His Gly Leu Ala Phe Ile Glu Gln Leu Glu His 
        195                 200                 205             


Gly Asp Ile Val Gly Leu Asn Pro Glu Thr Gly His Glu Gln Met Ala 
    210                 215                 220                 


Gly Leu Asn Phe Thr His Gly Ile Ala Gln Ala Leu Trp Ala Glu Lys 
225                 230                 235                 240 


Leu Phe His Ile Asp Leu Asn Gly Gln Arg Gly Ile Lys Tyr Asp Gln 
                245                 250                 255     


Asp Leu Val Phe Gly His Gly Asp Leu Thr Ser Ala Phe Phe Thr Val 
            260                 265                 270         


Asp Leu Leu Glu Asn Gly Phe Pro Asn Gly Gly Pro Lys Tyr Thr Gly 
        275                 280                 285             


Pro Arg His Phe Asp Tyr Lys Pro Ser Arg Thr Asp Gly Tyr Asp Gly 
    290                 295                 300                 


Val Trp Asp Ser Ala Lys Ala Asn Met Ser Met Tyr Leu Leu Leu Lys 
305                 310                 315                 320 


Glu Arg Ala Leu Ala Phe Arg Ala Asp Pro Glu Val Gln Glu Ala Met 
                325                 330                 335     


Lys Thr Ser Gly Val Phe Glu Leu Gly Glu Thr Thr Leu Asn Ala Gly 
            340                 345                 350         


Glu Ser Ala Ala Asp Leu Met Asn Asp Ser Ala Ser Phe Ala Gly Phe 
        355                 360                 365             


Asp Ala Glu Ala Ala Ala Glu Arg Asn Phe Ala Phe Ile Arg Leu Asn 
    370                 375                 380                 


Gln Leu Ala Ile Glu His Leu Leu Gly Ser Arg 
385                 390                 395 


<210>  47
<211>  1188
<212>  DNA
<213>  Arthrobacter sp. ZXY-2


<220>
<221>  CDS
<222>  (1)..(1188)
<223>  xylA gene encoding D-xylose isomerase

<300>
<308>  CP017421.1
<309>  2016-10-26
<313>  (58776)..(59963)

<400>  47
atg tcc ccg caa ccc aca ccc cag gac cgt ttc acc ttt ggc ctc tgg         48
Met Ser Pro Gln Pro Thr Pro Gln Asp Arg Phe Thr Phe Gly Leu Trp           
1               5                   10                  15                

act gtt ggc tgg acc ggc aat gat ccc ttc ggt gtt ccc acc cgc gag         96
Thr Val Gly Trp Thr Gly Asn Asp Pro Phe Gly Val Pro Thr Arg Glu           
            20                  25                  30                    

gcg ctg gac ccg gtg gaa gcc gtc cac aag ctg agt gag ctt ggc gcc        144
Ala Leu Asp Pro Val Glu Ala Val His Lys Leu Ser Glu Leu Gly Ala           
        35                  40                  45                        

tat ggc att acg ttc cat gac aac gat ctg gtc ccg ttc gac gcc acc        192
Tyr Gly Ile Thr Phe His Asp Asn Asp Leu Val Pro Phe Asp Ala Thr           
    50                  55                  60                            

gcg tcc gaa cgc gac ctc atc ctc aag aac ttc aag ggc gcc ctc gca        240
Ala Ser Glu Arg Asp Leu Ile Leu Lys Asn Phe Lys Gly Ala Leu Ala           
65                  70                  75                  80            

gaa acg ggc ctc aag gtg ccc atg gtc acc acc aac ctg ttc agc cac        288
Glu Thr Gly Leu Lys Val Pro Met Val Thr Thr Asn Leu Phe Ser His           
                85                  90                  95                

ccg gtc ttc aag gac ggc ggc ttc acg tcc aac gac cga tcc atc cgc        336
Pro Val Phe Lys Asp Gly Gly Phe Thr Ser Asn Asp Arg Ser Ile Arg           
            100                 105                 110                   

cgc tac gcc ctg agc aag gtc ctg agg aac atc gat ctt gcc gct gag        384
Arg Tyr Ala Leu Ser Lys Val Leu Arg Asn Ile Asp Leu Ala Ala Glu           
        115                 120                 125                       

ctc ggc gca gaa acg ttc gtc atg tgg ggc ggc cgc gaa ggc agc gag        432
Leu Gly Ala Glu Thr Phe Val Met Trp Gly Gly Arg Glu Gly Ser Glu           
    130                 135                 140                           

tat gac ggc tca aag gac ctt tcc gca gca ctg gac cgc atg aag gaa        480
Tyr Asp Gly Ser Lys Asp Leu Ser Ala Ala Leu Asp Arg Met Lys Glu           
145                 150                 155                 160           

ggc gtc gac acc gct gcg ggc tac atc aag gag aag ggc tat ggc ctg        528
Gly Val Asp Thr Ala Ala Gly Tyr Ile Lys Glu Lys Gly Tyr Gly Leu           
                165                 170                 175               

cgc atc gca ctg gag ccc aag ccg aac gag ccc agg ggc gac att ttc        576
Arg Ile Ala Leu Glu Pro Lys Pro Asn Glu Pro Arg Gly Asp Ile Phe           
            180                 185                 190                   

ctc ccg acc gta ggc cac gcc ctg gca ttt att gcc cag ctg gaa cac        624
Leu Pro Thr Val Gly His Ala Leu Ala Phe Ile Ala Gln Leu Glu His           
        195                 200                 205                       

ggc gac att gtc ggc ctc aac ccg gag acc ggc cac gag caa atg gca        672
Gly Asp Ile Val Gly Leu Asn Pro Glu Thr Gly His Glu Gln Met Ala           
    210                 215                 220                           

ggc ctg aac ttc acc cac gga atc gcc cag gca ctg tgg gcc ggc aag        720
Gly Leu Asn Phe Thr His Gly Ile Ala Gln Ala Leu Trp Ala Gly Lys           
225                 230                 235                 240           

ctc ttc cac att gat ctc aac ggc cag cgc ggc atc aag tac gac cag        768
Leu Phe His Ile Asp Leu Asn Gly Gln Arg Gly Ile Lys Tyr Asp Gln           
                245                 250                 255               

gac ctg gtg ttc ggc cac ggc gac ctc acc agc gcc ttc ttc acc gtc        816
Asp Leu Val Phe Gly His Gly Asp Leu Thr Ser Ala Phe Phe Thr Val           
            260                 265                 270                   

gac ctc ctg gag aac ggc ttc ccg aac ggc gga ccc aag tac gac ggt        864
Asp Leu Leu Glu Asn Gly Phe Pro Asn Gly Gly Pro Lys Tyr Asp Gly           
        275                 280                 285                       

ccg cgc cac ttc gac tac aag ccc tca cgc acc gac ggt tac gac ggc        912
Pro Arg His Phe Asp Tyr Lys Pro Ser Arg Thr Asp Gly Tyr Asp Gly           
    290                 295                 300                           

gtc tgg gag tcg gcc aag tcc aac atg gcc atg tac ctg ctc ctc aag        960
Val Trp Glu Ser Ala Lys Ser Asn Met Ala Met Tyr Leu Leu Leu Lys           
305                 310                 315                 320           

gaa cgt gcc gtt gcc ttc cgc gcg gac ccc gaa gtc cag gaa gca ctc       1008
Glu Arg Ala Val Ala Phe Arg Ala Asp Pro Glu Val Gln Glu Ala Leu           
                325                 330                 335               

gca acc tcc ggc gtg ttc gaa ctc ggc gaa tcc acc ctg gcc gcc ggc       1056
Ala Thr Ser Gly Val Phe Glu Leu Gly Glu Ser Thr Leu Ala Ala Gly           
            340                 345                 350                   

gag acc acc gcg gac ctc ctg gct gac gca tca gcc ttc gag tcg ttc       1104
Glu Thr Thr Ala Asp Leu Leu Ala Asp Ala Ser Ala Phe Glu Ser Phe           
        355                 360                 365                       

gac gcc aac aag gcc gcg gag cgc tcc ttc gcc ttc atc agg ctg aac       1152
Asp Ala Asn Lys Ala Ala Glu Arg Ser Phe Ala Phe Ile Arg Leu Asn           
    370                 375                 380                           

cag ctg gcc atc gag cac ctc ctc ggc gcc cgc tga                       1188
Gln Leu Ala Ile Glu His Leu Leu Gly Ala Arg                               
385                 390                 395                               


<210>  48
<211>  395
<212>  PRT
<213>  Arthrobacter sp. ZXY-2

<400>  48

Met Ser Pro Gln Pro Thr Pro Gln Asp Arg Phe Thr Phe Gly Leu Trp 
1               5                   10                  15      


Thr Val Gly Trp Thr Gly Asn Asp Pro Phe Gly Val Pro Thr Arg Glu 
            20                  25                  30          


Ala Leu Asp Pro Val Glu Ala Val His Lys Leu Ser Glu Leu Gly Ala 
        35                  40                  45              


Tyr Gly Ile Thr Phe His Asp Asn Asp Leu Val Pro Phe Asp Ala Thr 
    50                  55                  60                  


Ala Ser Glu Arg Asp Leu Ile Leu Lys Asn Phe Lys Gly Ala Leu Ala 
65                  70                  75                  80  


Glu Thr Gly Leu Lys Val Pro Met Val Thr Thr Asn Leu Phe Ser His 
                85                  90                  95      


Pro Val Phe Lys Asp Gly Gly Phe Thr Ser Asn Asp Arg Ser Ile Arg 
            100                 105                 110         


Arg Tyr Ala Leu Ser Lys Val Leu Arg Asn Ile Asp Leu Ala Ala Glu 
        115                 120                 125             


Leu Gly Ala Glu Thr Phe Val Met Trp Gly Gly Arg Glu Gly Ser Glu 
    130                 135                 140                 


Tyr Asp Gly Ser Lys Asp Leu Ser Ala Ala Leu Asp Arg Met Lys Glu 
145                 150                 155                 160 


Gly Val Asp Thr Ala Ala Gly Tyr Ile Lys Glu Lys Gly Tyr Gly Leu 
                165                 170                 175     


Arg Ile Ala Leu Glu Pro Lys Pro Asn Glu Pro Arg Gly Asp Ile Phe 
            180                 185                 190         


Leu Pro Thr Val Gly His Ala Leu Ala Phe Ile Ala Gln Leu Glu His 
        195                 200                 205             


Gly Asp Ile Val Gly Leu Asn Pro Glu Thr Gly His Glu Gln Met Ala 
    210                 215                 220                 


Gly Leu Asn Phe Thr His Gly Ile Ala Gln Ala Leu Trp Ala Gly Lys 
225                 230                 235                 240 


Leu Phe His Ile Asp Leu Asn Gly Gln Arg Gly Ile Lys Tyr Asp Gln 
                245                 250                 255     


Asp Leu Val Phe Gly His Gly Asp Leu Thr Ser Ala Phe Phe Thr Val 
            260                 265                 270         


Asp Leu Leu Glu Asn Gly Phe Pro Asn Gly Gly Pro Lys Tyr Asp Gly 
        275                 280                 285             


Pro Arg His Phe Asp Tyr Lys Pro Ser Arg Thr Asp Gly Tyr Asp Gly 
    290                 295                 300                 


Val Trp Glu Ser Ala Lys Ser Asn Met Ala Met Tyr Leu Leu Leu Lys 
305                 310                 315                 320 


Glu Arg Ala Val Ala Phe Arg Ala Asp Pro Glu Val Gln Glu Ala Leu 
                325                 330                 335     


Ala Thr Ser Gly Val Phe Glu Leu Gly Glu Ser Thr Leu Ala Ala Gly 
            340                 345                 350         


Glu Thr Thr Ala Asp Leu Leu Ala Asp Ala Ser Ala Phe Glu Ser Phe 
        355                 360                 365             


Asp Ala Asn Lys Ala Ala Glu Arg Ser Phe Ala Phe Ile Arg Leu Asn 
    370                 375                 380                 


Gln Leu Ala Ile Glu His Leu Leu Gly Ala Arg 
385                 390                 395 


<210>  49
<211>  1422
<212>  DNA
<213>  Synthetic


<220>
<221>  CDS
<222>  (1)..(1422)
<223>  codon optimized araA gene encoding arabinose isomerase 
       (originating from B. coagulans)

<400>  49
atg ctg aag atc aag gat tac gaa ttc tgg ttc atc gtg ggc tcc cag         48
Met Leu Lys Ile Lys Asp Tyr Glu Phe Trp Phe Ile Val Gly Ser Gln           
1               5                   10                  15                

cac ctg tac ggc aag gaa acc ctg gat gca gtc aag gaa gac gcc gag         96
His Leu Tyr Gly Lys Glu Thr Leu Asp Ala Val Lys Glu Asp Ala Glu           
            20                  25                  30                    

aag atc atc aac gaa atc aac gca tcc ggc aag ctg cca tac cca atc        144
Lys Ile Ile Asn Glu Ile Asn Ala Ser Gly Lys Leu Pro Tyr Pro Ile           
        35                  40                  45                        

gtg ttc aag acc gtc gca acc acc gcc gat tcc atc acc cag gtg atg        192
Val Phe Lys Thr Val Ala Thr Thr Ala Asp Ser Ile Thr Gln Val Met           
    50                  55                  60                            

aag gag gtc aac tac aac gac aac gtg gcc ggc gtc atc acc tgg atg        240
Lys Glu Val Asn Tyr Asn Asp Asn Val Ala Gly Val Ile Thr Trp Met           
65                  70                  75                  80            

cac acc ttc tcc cca gct aag aac tgg atc cgc ggc acc aag ctg ctc        288
His Thr Phe Ser Pro Ala Lys Asn Trp Ile Arg Gly Thr Lys Leu Leu           
                85                  90                  95                

cag aag cca ctg ctc cac ctg gcc acc cag ttc ctc gat cac atc cca        336
Gln Lys Pro Leu Leu His Leu Ala Thr Gln Phe Leu Asp His Ile Pro           
            100                 105                 110                   

tgg gaa acc atc gat atg gac tac atg aac ctg cac cag tcc gca cac        384
Trp Glu Thr Ile Asp Met Asp Tyr Met Asn Leu His Gln Ser Ala His           
        115                 120                 125                       

ggc gac cgc gag tac ggc ttc atc aac gcc cgc ctc aac aag aac aac        432
Gly Asp Arg Glu Tyr Gly Phe Ile Asn Ala Arg Leu Asn Lys Asn Asn           
    130                 135                 140                           

aag atc gtg gtc ggc cac tgg aag gat gaa aag gtg cag acc cag atc        480
Lys Ile Val Val Gly His Trp Lys Asp Glu Lys Val Gln Thr Gln Ile           
145                 150                 155                 160           

ggc cag tgg atg gac gtg gcc gtc gct ttc aac gag tcc ttc aac atc        528
Gly Gln Trp Met Asp Val Ala Val Ala Phe Asn Glu Ser Phe Asn Ile           
                165                 170                 175               

aag gtc gca cgc ttc ggc gat aac atg cgc aac gtg gct gtc acc gat        576
Lys Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Asp           
            180                 185                 190                   

ggc gac aag atc gaa gca cag atc cag ttc ggc tgg acc gtg gat tac        624
Gly Asp Lys Ile Glu Ala Gln Ile Gln Phe Gly Trp Thr Val Asp Tyr           
        195                 200                 205                       

tac ggc atc ggc gac ctg gtg gct gaa atg aag gag gtc acc gac cag        672
Tyr Gly Ile Gly Asp Leu Val Ala Glu Met Lys Glu Val Thr Asp Gln           
    210                 215                 220                           

gaa atc gag gct gtc tgc gca gaa tgc cag gag aag tac gaa ctc gtg        720
Glu Ile Glu Ala Val Cys Ala Glu Cys Gln Glu Lys Tyr Glu Leu Val           
225                 230                 235                 240           

gtc ggc aac aac gat cca gca tac ttc gag gac cac gtg aag gaa cag        768
Val Gly Asn Asn Asp Pro Ala Tyr Phe Glu Asp His Val Lys Glu Gln           
                245                 250                 255               

atc cgc atc gag atc gca ctg cgc aag ttc ctc gat cgc ggc ggc tac        816
Ile Arg Ile Glu Ile Ala Leu Arg Lys Phe Leu Asp Arg Gly Gly Tyr           
            260                 265                 270                   

acc gcc ttc acc acc aac ttc gaa gac ctg tgg ggc atg aag cag ctc        864
Thr Ala Phe Thr Thr Asn Phe Glu Asp Leu Trp Gly Met Lys Gln Leu           
        275                 280                 285                       

cca ggc atg gct gtg cag cgc ctg aac gca gaa ggt tac ggt ttc gca        912
Pro Gly Met Ala Val Gln Arg Leu Asn Ala Glu Gly Tyr Gly Phe Ala           
    290                 295                 300                           

ggc gag ggt gat tgg aag acc gca gcc ctg gac cgc ctc gtg aag atc        960
Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Asp Arg Leu Val Lys Ile           
305                 310                 315                 320           

atg gcc cac aac gaa aag acc ggc ttc atg gag gat tac acc tac aac       1008
Met Ala His Asn Glu Lys Thr Gly Phe Met Glu Asp Tyr Thr Tyr Asn           
                325                 330                 335               

ctg gtg aag ggc cac gaa gag atc ctg ggc tcc cac atg ctc gaa gtc       1056
Leu Val Lys Gly His Glu Glu Ile Leu Gly Ser His Met Leu Glu Val           
            340                 345                 350                   

gac cca acc ctc gct tcc ggc aag atc cgc gtg gaa gtc cac cca ctg       1104
Asp Pro Thr Leu Ala Ser Gly Lys Ile Arg Val Glu Val His Pro Leu           
        355                 360                 365                       

ggt atc ggc gat cgc gag gac cca gct cgt ctc gtg ttc gat ggc acc       1152
Gly Ile Gly Asp Arg Glu Asp Pro Ala Arg Leu Val Phe Asp Gly Thr           
    370                 375                 380                           

gat ggc gac gca gtg aac ctg acc gtc tcc gat ttc ggc gac cag ttc       1200
Asp Gly Asp Ala Val Asn Leu Thr Val Ser Asp Phe Gly Asp Gln Phe           
385                 390                 395                 400           

aag ctc gtg atg tac gaa gtc gac ggc aag aag cca gcc gag gct gca       1248
Lys Leu Val Met Tyr Glu Val Asp Gly Lys Lys Pro Ala Glu Ala Ala           
                405                 410                 415               

cca aag ctg cca gtg gct cgt cag ctc tgg acc cca aag cca ggc ttc       1296
Pro Lys Leu Pro Val Ala Arg Gln Leu Trp Thr Pro Lys Pro Gly Phe           
            420                 425                 430                   

tac gaa ggc gtc cag aag tgg atc gag aac ggt ggt ggt cac cac acc       1344
Tyr Glu Gly Val Gln Lys Trp Ile Glu Asn Gly Gly Gly His His Thr           
        435                 440                 445                       

gtg ctg tcc ttc gcc gtc acc gct gag cag atc gaa gat ttc gca aag       1392
Val Leu Ser Phe Ala Val Thr Ala Glu Gln Ile Glu Asp Phe Ala Lys           
    450                 455                 460                           

atg gtg ggc ctc aag acc gtc aag atc taa                               1422
Met Val Gly Leu Lys Thr Val Lys Ile                                       
465                 470                                                   


<210>  50
<211>  473
<212>  PRT
<213>  Synthetic

<400>  50

Met Leu Lys Ile Lys Asp Tyr Glu Phe Trp Phe Ile Val Gly Ser Gln 
1               5                   10                  15      


His Leu Tyr Gly Lys Glu Thr Leu Asp Ala Val Lys Glu Asp Ala Glu 
            20                  25                  30          


Lys Ile Ile Asn Glu Ile Asn Ala Ser Gly Lys Leu Pro Tyr Pro Ile 
        35                  40                  45              


Val Phe Lys Thr Val Ala Thr Thr Ala Asp Ser Ile Thr Gln Val Met 
    50                  55                  60                  


Lys Glu Val Asn Tyr Asn Asp Asn Val Ala Gly Val Ile Thr Trp Met 
65                  70                  75                  80  


His Thr Phe Ser Pro Ala Lys Asn Trp Ile Arg Gly Thr Lys Leu Leu 
                85                  90                  95      


Gln Lys Pro Leu Leu His Leu Ala Thr Gln Phe Leu Asp His Ile Pro 
            100                 105                 110         


Trp Glu Thr Ile Asp Met Asp Tyr Met Asn Leu His Gln Ser Ala His 
        115                 120                 125             


Gly Asp Arg Glu Tyr Gly Phe Ile Asn Ala Arg Leu Asn Lys Asn Asn 
    130                 135                 140                 


Lys Ile Val Val Gly His Trp Lys Asp Glu Lys Val Gln Thr Gln Ile 
145                 150                 155                 160 


Gly Gln Trp Met Asp Val Ala Val Ala Phe Asn Glu Ser Phe Asn Ile 
                165                 170                 175     


Lys Val Ala Arg Phe Gly Asp Asn Met Arg Asn Val Ala Val Thr Asp 
            180                 185                 190         


Gly Asp Lys Ile Glu Ala Gln Ile Gln Phe Gly Trp Thr Val Asp Tyr 
        195                 200                 205             


Tyr Gly Ile Gly Asp Leu Val Ala Glu Met Lys Glu Val Thr Asp Gln 
    210                 215                 220                 


Glu Ile Glu Ala Val Cys Ala Glu Cys Gln Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Val Gly Asn Asn Asp Pro Ala Tyr Phe Glu Asp His Val Lys Glu Gln 
                245                 250                 255     


Ile Arg Ile Glu Ile Ala Leu Arg Lys Phe Leu Asp Arg Gly Gly Tyr 
            260                 265                 270         


Thr Ala Phe Thr Thr Asn Phe Glu Asp Leu Trp Gly Met Lys Gln Leu 
        275                 280                 285             


Pro Gly Met Ala Val Gln Arg Leu Asn Ala Glu Gly Tyr Gly Phe Ala 
    290                 295                 300                 


Gly Glu Gly Asp Trp Lys Thr Ala Ala Leu Asp Arg Leu Val Lys Ile 
305                 310                 315                 320 


Met Ala His Asn Glu Lys Thr Gly Phe Met Glu Asp Tyr Thr Tyr Asn 
                325                 330                 335     


Leu Val Lys Gly His Glu Glu Ile Leu Gly Ser His Met Leu Glu Val 
            340                 345                 350         


Asp Pro Thr Leu Ala Ser Gly Lys Ile Arg Val Glu Val His Pro Leu 
        355                 360                 365             


Gly Ile Gly Asp Arg Glu Asp Pro Ala Arg Leu Val Phe Asp Gly Thr 
    370                 375                 380                 


Asp Gly Asp Ala Val Asn Leu Thr Val Ser Asp Phe Gly Asp Gln Phe 
385                 390                 395                 400 


Lys Leu Val Met Tyr Glu Val Asp Gly Lys Lys Pro Ala Glu Ala Ala 
                405                 410                 415     


Pro Lys Leu Pro Val Ala Arg Gln Leu Trp Thr Pro Lys Pro Gly Phe 
            420                 425                 430         


Tyr Glu Gly Val Gln Lys Trp Ile Glu Asn Gly Gly Gly His His Thr 
        435                 440                 445             


Val Leu Ser Phe Ala Val Thr Ala Glu Gln Ile Glu Asp Phe Ala Lys 
    450                 455                 460                 


Met Val Gly Leu Lys Thr Val Lys Ile 
465                 470             


<210>  51
<211>  77
<212>  DNA
<213>  Synthetic


<220>
<221>  promoter
<222>  (1)..(77)
<223>  trp promoter core fragment

<400>  51
gagctgttga caattaatca tccggctcgt ataatgtgtg gaattgtgag cggataacaa       60

tttcacacag gaaacag                                                      77


