                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       QIN, Haiying
       FRY, Terry J.
 
<120>  ANTI-CD33 CHIMERIC ANTIGEN RECEPTORS AND THEIR USES

<130>  741580

<150>  US 62/643,015
<151>  2018-03-14

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  1
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1

Met 
1   


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Ala Ala Arg Pro 
            20  


<210>  3
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  5
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg 
            100                 105                 110         


<210>  6
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  7
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  8
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  10
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40          


<210>  11
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  12
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Ala Ala Arg Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
            20                  25                  30          


Ala Leu Leu Leu His Ala Ala Arg Pro 
        35                  40      


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  14
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  15
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  16
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17

Gly Gly Gly Gly Ser 
1               5   


<210>  18
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Ile Thr Asp Ser Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Ser Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro 
                85                  90                  95      


Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Phe Tyr Tyr Cys Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
                165                 170                 175     


Ala Ser Glu Ser Leu Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser 
        195                 200                 205             


Asn Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Val Glu Val Lys Arg Thr Ser Ser Gly Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  19
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Ile Thr Asp Ser Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Ser Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro 
                85                  90                  95      


Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Phe Tyr Tyr Cys Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
                165                 170                 175     


Ala Ser Glu Ser Leu Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser 
        195                 200                 205             


Asn Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Val Glu Val Lys Arg Ala Ala Ala Ile Glu Val Met Tyr 
            260                 265                 270         


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
        275                 280                 285             


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
    290                 295                 300                 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
305                 310                 315                 320 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  20
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
            20                  25                  30          


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val Gln 
        35                  40                  45              


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
    50                  55                  60                  


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met His Trp Val Arg 
65                  70                  75                  80  


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile 
            100                 105                 110         


Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu 
        115                 120                 125             


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala 
    130                 135                 140                 


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                165                 170                 175     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            180                 185                 190         


Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser 
        195                 200                 205             


Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
    210                 215                 220                 


Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser Arg Phe Ser 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Ser Ser Leu Gln 
                245                 250                 255     


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro 
            260                 265                 270         


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Ser Ser Gly 
        275                 280                 285             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    290                 295                 300                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
305                 310                 315                 320 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                325                 330                 335     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            340                 345                 350         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  21
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
            20                  25                  30          


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Val Gln 
        35                  40                  45              


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
    50                  55                  60                  


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met His Trp Val Arg 
65                  70                  75                  80  


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile 
            100                 105                 110         


Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu 
        115                 120                 125             


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala 
    130                 135                 140                 


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                165                 170                 175     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            180                 185                 190         


Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser 
        195                 200                 205             


Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
    210                 215                 220                 


Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser Arg Phe Ser 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Ser Ser Leu Gln 
                245                 250                 255     


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro 
            260                 265                 270         


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Ser Ser Gly 
        275                 280                 285             


Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
    290                 295                 300                 


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
305                 310                 315                 320 


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
                325                 330                 335     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            340                 345                 350         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        355                 360                 365             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    370                 375                 380                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  22
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser 
                85                  90                  95      


Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
                165                 170                 175     


Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
        195                 200                 205             


Asn Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Ser Gly Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  23
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser 
                85                  90                  95      


Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
                165                 170                 175     


Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
        195                 200                 205             


Asn Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Ser Gly Ala Ala Ala Ile Glu Val Met 
            260                 265                 270         


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
        275                 280                 285             


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
    290                 295                 300                 


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
305                 310                 315                 320 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  24
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24
atggccctgc ctgtgacagc cctgctgctg cccctggctc tgctgctgca tgccgccaga       60

cctgaggtgc agctggtgca gtctggcgcc gaagtgaaga aacccggcag cagcgtgaag      120

gtgtcctgca aggccagcgg ctacaccatc accgacagca acatccactg ggtgcgccag      180

gcccctggcc agagcctgga atggatcggc tacatctacc cctacaacgg cggcaccgac      240

tacaaccaga agttcaagaa ccgggccacc ctgaccgtgg acaaccccac caacaccgcc      300

tacatggaac tgagcagcct gcggagcgag gacaccgcct tctactactg cgtgaacggc      360

aacccctggc tggcctactg gggccaggga accctggtga cagtgtctag cggcggaggc      420

ggatctggag ggggaggatc tggcggcgga ggaagcgaca tccagctgac ccagagcccc      480

agcaccctga gcgccagcgt gggcgacaga gtgaccatca cctgtcgggc cagcgagagc      540

ctggacaact acggcatccg gtttctgacc tggttccagc agaagcccgg caaggccccc      600

aagctgctga tgtacgccgc cagcaatcag ggcagcggcg tgcccagcag attcagcggc      660

tctggcagcg gaaccgagtt caccctgacc atcagcagcc tgcagcccga cgacttcgcc      720

acctactact gccagcagac caaagaggtg ccctggtcct tcggccaggg caccaaggtg      780

gaagtgaagc ggactagttc cggaaccacg acgccagcgc cgcgaccacc aacaccggcg      840

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg      900

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgctaa                               1476


<210>  25
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
atggccctgc ctgtgacagc cctgctgctg cccctggctc tgctgctgca tgccgccaga       60

cctgaggtgc agctggtgca gtctggcgcc gaagtgaaga aacccggcag cagcgtgaag      120

gtgtcctgca aggccagcgg ctacaccatc accgacagca acatccactg ggtgcgccag      180

gcccctggcc agagcctgga atggatcggc tacatctacc cctacaacgg cggcaccgac      240

tacaaccaga agttcaagaa ccgggccacc ctgaccgtgg acaaccccac caacaccgcc      300

tacatggaac tgagcagcct gcggagcgag gacaccgcct tctactactg cgtgaacggc      360

aacccctggc tggcctactg gggccaggga accctggtga cagtgtctag cggcggaggc      420

ggatctggag ggggaggatc tggcggcgga ggaagcgaca tccagctgac ccagagcccc      480

agcaccctga gcgccagcgt gggcgacaga gtgaccatca cctgtcgggc cagcgagagc      540

ctggacaact acggcatccg gtttctgacc tggttccagc agaagcccgg caaggccccc      600

aagctgctga tgtacgccgc cagcaatcag ggcagcggcg tgcccagcag attcagcggc      660

tctggcagcg gaaccgagtt caccctgacc atcagcagcc tgcagcccga cgacttcgcc      720

acctactact gccagcagac caaagaggtg ccctggtcct tcggccaggg caccaaggtg      780

gaagtgaagc ggactagttc cggagccgcc gccatcgaag tgatgtaccc ccctccctac      840

ctggataacg agaagagcaa cggcaccatc atccacgtga agggaaagca cctgtgtccc      900

agccccctgt ttcccggccc tagcaagccc ttctgggtgc tggtggtggt cggcggagtg      960

ctggcctgct acagcctcct ggtgaccgtg gccttcatca tcttctgggt gaggagcaag     1020

aggtccaggc tgctgcacag cgactacatg aatatgaccc ccagaaggcc cggccccacc     1080

agaaagcact atcagcccta cgcccccccc agggactttg ccgcctacag gagcagggtg     1140

aagttcagca gatccgccga tgcccctgct taccagcagg gccagaacca gctgtataac     1200

gagctgaacc tgggcaggag ggaggaatac gacgtgctgg ataagaggag gggaagggac     1260

cccgagatgg gcggaaagcc caggaggaag aacccccagg agggcctgta caatgagctg     1320

cagaaagaca agatggccga ggcctacagc gagatcggca tgaagggcga gaggaggagg     1380

ggcaagggcc atgacggcct gtaccaaggc ctgtccaccg ccaccaagga tacctacgac     1440

gccctgcaca tgcaggccct gcctcccagg ggatcctaa                            1479


<210>  26
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
atggccctgc ctgtgacagc cctgctgctg cccctggctc tgctgctgca tgccgccaga       60

cctatggctc tgcccgtgac cgctctcctc ctgccactgg cactgctcct ccacgctgct      120

agaccccagg tgcagctggt gcagtctggc gccgaagtga agaaacccgg cagcagcgtg      180

aaggtgtcct gcaaggccag cggctacacc ttcaccgact acaacatgca ctgggtgcgc      240

caggctccag gccagggact ggaatggatc ggctacatct acccctacaa cggcggcacc      300

ggctacaacc agaagttcaa gagcaaggcc accatcaccg ccgacgagag caccaacacc      360

gcctacatgg aactgagcag cctgcggagc gaggacaccg ccgtgtacta ctgcgccaga      420

ggcagacccg ccatggacta ctggggccag ggcaccctgg tgacagtgtc tagcggaggc      480

ggaggctctg gcggcggagg aagtggcgga ggcggcagcg atatccagat gacccagagc      540

cccagcagcc tgagcgccag cgtgggcgac agagtgacca tcacctgtcg ggccagcgag      600

agcgtggaca actacggcat cagcttcatg aactggttcc agcagaagcc cggcaaggcc      660

cccaagctgc tgatctacgc cgccagcaat cagggcagcg gcgtgcccag cagattcagc      720

ggctctggca gcggcaccga cttcaccctg aacatcagca gcctgcagcc cgacgacttc      780

gccacctact actgccagca gagcaaagag gtgccctgga ccttcggaca gggcaccaag      840

gtggaaatca agactagttc cggaaccacg acgccagcgc cgcgaccacc aacaccggcg      900

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg      960

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg     1020

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1080

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1140

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1200

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1260

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1320

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1380

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1440

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1500

gacgcccttc acatgcaggc cctgccccct cgctaa                               1536


<210>  27
<211>  1539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
atggccctgc ctgtgacagc cctgctgctg cccctggctc tgctgctgca tgccgccaga       60

cctatggctc tgcccgtgac cgctctcctc ctgccactgg cactgctcct ccacgctgct      120

agaccccagg tgcagctggt gcagtctggc gccgaagtga agaaacccgg cagcagcgtg      180

aaggtgtcct gcaaggccag cggctacacc ttcaccgact acaacatgca ctgggtgcgc      240

caggctccag gccagggact ggaatggatc ggctacatct acccctacaa cggcggcacc      300

ggctacaacc agaagttcaa gagcaaggcc accatcaccg ccgacgagag caccaacacc      360

gcctacatgg aactgagcag cctgcggagc gaggacaccg ccgtgtacta ctgcgccaga      420

ggcagacccg ccatggacta ctggggccag ggcaccctgg tgacagtgtc tagcggaggc      480

ggaggctctg gcggcggagg aagtggcgga ggcggcagcg atatccagat gacccagagc      540

cccagcagcc tgagcgccag cgtgggcgac agagtgacca tcacctgtcg ggccagcgag      600

agcgtggaca actacggcat cagcttcatg aactggttcc agcagaagcc cggcaaggcc      660

cccaagctgc tgatctacgc cgccagcaat cagggcagcg gcgtgcccag cagattcagc      720

ggctctggca gcggcaccga cttcaccctg aacatcagca gcctgcagcc cgacgacttc      780

gccacctact actgccagca gagcaaagag gtgccctgga ccttcggaca gggcaccaag      840

gtggaaatca agactagttc cggagccgcc gccatcgaag tgatgtaccc ccctccctac      900

ctggataacg agaagagcaa cggcaccatc atccacgtga agggaaagca cctgtgtccc      960

agccccctgt ttcccggccc tagcaagccc ttctgggtgc tggtggtggt cggcggagtg     1020

ctggcctgct acagcctcct ggtgaccgtg gccttcatca tcttctgggt gaggagcaag     1080

aggtccaggc tgctgcacag cgactacatg aatatgaccc ccagaaggcc cggccccacc     1140

agaaagcact atcagcccta cgcccccccc agggactttg ccgcctacag gagcagggtg     1200

aagttcagca gatccgccga tgcccctgct taccagcagg gccagaacca gctgtataac     1260

gagctgaacc tgggcaggag ggaggaatac gacgtgctgg ataagaggag gggaagggac     1320

cccgagatgg gcggaaagcc caggaggaag aacccccagg agggcctgta caatgagctg     1380

cagaaagaca agatggccga ggcctacagc gagatcggca tgaagggcga gaggaggagg     1440

ggcaagggcc atgacggcct gtaccaaggc ctgtccaccg ccaccaagga tacctacgac     1500

gccctgcaca tgcaggccct gcctcccagg ggatcctaa                            1539


<210>  28
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28
atggctctgc ccgtcacagc tctgctgctg cctctggccc tgctgctgca cgccgccaga       60

cctcaggtgc agctcgtgca gagcggcgct gaggtgaaga aacctggcag cagcgtgaag      120

gtgagctgca aggcctccgg ctacaccttc accgactaca acatgcactg ggtgaggcaa      180

gcccctggcc agggactgga gtggatcggc tacatctacc cttacaacgg cggcacaggc      240

tacaaccaga agttcaagtc caaggccacc atcaccgccg atgagtccac caataccgcc      300

tacatggagc tcagcagcct gaggtccgag gacacagccg tctactactg cgccaggggc      360

aggcccgcta tggactactg gggccagggc accctggtga cagtgagctc tggtggcggc      420

ggatccggcg gcggcggcag cggcggcggc ggctccgaca ttcagatgac ccagagccct      480

agcagcctga gcgcttccgt gggagacagg gtgaccatca catgcagggc ctccgagagc      540

gtggacaatt acggcatcag cttcatgaac tggttccagc agaagcccgg caaggccccc      600

aaactgctga tctatgccgc cagcaatcag ggctccggcg tgcctagcag gttttccggc      660

agcggcagcg gcaccgactt taccctgacc atctccagcc tgcagcctga cgatttcgcc      720

acctactact gccagcagag caaggaggtg ccttggacct ttggacaggg cacaaaggtg      780

gagatcaagt ccggaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1020

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1080

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctaa                                         1467


<210>  29
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
atggctctgc ccgtcacagc tctgctgctg cctctggccc tgctgctgca cgccgccaga       60

cctcaggtgc agctcgtgca gagcggcgct gaggtgaaga aacctggcag cagcgtgaag      120

gtgagctgca aggcctccgg ctacaccttc accgactaca acatgcactg ggtgaggcaa      180

gcccctggcc agggactgga gtggatcggc tacatctacc cttacaacgg cggcacaggc      240

tacaaccaga agttcaagtc caaggccacc atcaccgccg atgagtccac caataccgcc      300

tacatggagc tcagcagcct gaggtccgag gacacagccg tctactactg cgccaggggc      360

aggcccgcta tggactactg gggccagggc accctggtga cagtgagctc tggtggcggc      420

ggatccggcg gcggcggcag cggcggcggc ggctccgaca ttcagatgac ccagagccct      480

agcagcctga gcgcttccgt gggagacagg gtgaccatca catgcagggc ctccgagagc      540

gtggacaatt acggcatcag cttcatgaac tggttccagc agaagcccgg caaggccccc      600

aaactgctga tctatgccgc cagcaatcag ggctccggcg tgcctagcag gttttccggc      660

agcggcagcg gcaccgactt taccctgacc atctccagcc tgcagcctga cgatttcgcc      720

acctactact gccagcagag caaggaggtg ccttggacct ttggacaggg cacaaaggtg      780

gagatcaagt ccggagccgc cgccatcgaa gtgatgtacc cccctcccta cctggataac      840

gagaagagca acggcaccat catccacgtg aagggaaagc acctgtgtcc cagccccctg      900

tttcccggcc ctagcaagcc cttctgggtg ctggtggtgg tcggcggagt gctggcctgc      960

tacagcctcc tggtgaccgt ggccttcatc atcttctggg tgaggagcaa gaggtccagg     1020

ctgctgcaca gcgactacat gaatatgacc cccagaaggc ccggccccac cagaaagcac     1080

tatcagccct acgccccccc cagggacttt gccgcctaca ggagcagggt gaagttcagc     1140

agatccgccg atgcccctgc ttaccagcag ggccagaacc agctgtataa cgagctgaac     1200

ctgggcagga gggaggaata cgacgtgctg gataagagga ggggaaggga ccccgagatg     1260

ggcggaaagc ccaggaggaa gaacccccag gagggcctgt acaatgagct gcagaaagac     1320

aagatggccg aggcctacag cgagatcggc atgaagggcg agaggaggag gggcaagggc     1380

catgacggcc tgtaccaagg cctgtccacc gccaccaagg atacctacga cgccctgcac     1440

atgcaggccc tgcctcccag gggatcctaa                                      1470


<210>  30
<211>  7691
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30
gacaatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt       60

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc      120

cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag      180

ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc      240

actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc      300

cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg      360

ctgttgggca ctgacaattc cgtggtgttg tcggggaagc tgacgtcctt tccatggctg      420

ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc      480

ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt      540

cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc gcctggaatt      600

cgagctcggt acctttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt      660

taaaagaaaa ggggggactg gaagggctaa ttcactccca acgaagacaa gatctgcttt      720

ttgcttgtac tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac      780

tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg      840

cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga      900

aaatctctag cagtagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga      960

aatgaatatc agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa     1020

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt     1080

tgtccaaact catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc     1140

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc     1200

cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct     1260

aggcttttgc gtcgagacgt acccaattcg ccctatagtg agtcgtatta cgcgcgctca     1320

ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc     1380

cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc     1440

ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag cggcgcatta     1500

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     1560

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     1620

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     1680

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     1740

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     1800

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     1860

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta     1920

acgcttacaa tttaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat     1980

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc     2040

aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct     2100

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     2160

atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta     2220

agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc     2280

tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca     2340

tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg     2400

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     2460

ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca     2520

tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa     2580

acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa     2640

ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg gaggcggata     2700

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     2760

ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc     2820

cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata     2880

gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt     2940

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     3000

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     3060

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     3120

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     3180

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     3240

ttcttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     3300

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     3360

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     3420

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     3480

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     3540

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     3600

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     3660

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     3720

tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc     3780

gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg     3840

agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt     3900

ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc     3960

gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc     4020

ttccggctcg tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct     4080

atgaccatga ttacgccaag cgcgcaatta accctcacta aagggaacaa aagctggagc     4140

tgcaagctta atgtagtctt atgcaatact cttgtagtct tgcaacatgg taacgatgag     4200

ttagcaacat gccttacaag gagagaaaaa gcaccgtgca tgccgattgg tggaagtaag     4260

gtggtacgat cgtgccttat taggaaggca acagacgggt ctgacatgga ttggacgaac     4320

cactgaattg ccgcattgca gagatattgt atttaagtgc ctagctcgat acataaacgg     4380

gtctctctgg ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact     4440

gcttaagcct caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg     4500

tgactctggt aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag     4560

tggcgcccga acagggactt gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg     4620

actcggcttg ctgaagcgcg cacggcaaga ggcgaggggc ggcgactggt gagtacgcca     4680

aaaattttga ctagcggagg ctagaaggag agagatgggt gcgagagcgt cagtattaag     4740

cgggggagaa ttagatcgcg atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa     4800

tataaattaa aacatatagt atgggcaagc agggagctag aacgattcgc agttaatcct     4860

ggcctgttag aaacatcaga aggctgtaga caaatactgg gacagctaca accatccctt     4920

cagacaggat cagaagaact tagatcatta tataatacag tagcaaccct ctattgtgtg     4980

catcaaagga tagagataaa agacaccaag gaagctttag acaagataga ggaagagcaa     5040

aacaaaagta agaccaccgc acagcaagcg gccgctgatc ttcagacctg gaggaggaga     5100

tatgagggac aattggagaa gtgaattata taaatataaa gtagtaaaaa ttgaaccatt     5160

aggagtagca cccaccaagg caaagagaag agtggtgcag agagaaaaaa gagcagtggg     5220

aataggagct ttgttccttg ggttcttggg agcagcagga agcactatgg gcgcagcgtc     5280

aatgacgctg acggtacagg ccagacaatt attgtctggt atagtgcagc agcagaacaa     5340

tttgctgagg gctattgagg cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa     5400

gcagctccag gcaagaatcc tggctgtgga aagataccta aaggatcaac agctcctggg     5460

gatttggggt tgctctggaa aactcatttg caccactgct gtgccttgga atgctagttg     5520

gagtaataaa tctctggaac agatttggaa tcacacgacc tggatggagt gggacagaga     5580

aattaacaat tacacaagct taatacactc cttaattgaa gaatcgcaaa accagcaaga     5640

aaagaatgaa caagaattat tggaattaga taaatgggca agtttgtgga attggtttaa     5700

cataacaaat tggctgtggt atataaaatt attcataatg atagtaggag gcttggtagg     5760

tttaagaata gtttttgctg tactttctat agtgaataga gttaggcagg gatattcacc     5820

attatcgttt cagacccacc tcccaacccc gaggggaccc gacaggcccg aaggaataga     5880

agaagaaggt ggagagagag acagagacag atccattcga ttagtgaacg gatctcgacg     5940

gtatcgatta gactgtagcc caggaatatg gcagctagat tgtacacatt tagaaggaaa     6000

agttatcttg gtagcagttc atgtagccag tggatatata gaagcagaag taattccagc     6060

agagacaggg caagaaacag catacttcct cttaaaatta gcaggaagat ggccagtaaa     6120

aacagtacat acagacaatg gcagcaattt caccagtact acagttaagg ccgcctgttg     6180

gtgggcgggg atcaagcagg aatttggcat tccctacaat ccccaaagtc aaggagtaat     6240

agaatctatg aataaagaat taaagaaaat tataggacag gtaagagatc aggctgaaca     6300

tcttaagaca gcagtacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     6360

tgggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta     6420

aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca     6480

gagatccagt ttggctgcat acgcgtcgtg aggctccggt gcccgtcagt gggcagagcg     6540

cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta     6600

gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc     6660

cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa     6720

cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt tcccgcgggc ctggcctctt     6780

tacgggttat ggcccttgcg tgccttgaat tacttccacc tggctgcagt acgtgattct     6840

tgatcccgag cttcgggttg gaagtgggtg ggagagttcg aggccttgcg cttaaggagc     6900

cccttcgcct cgtgcttgag ttgaggcctg gcctgggcgc tggggccgcc gcgtgcgaat     6960

ctggtggcac cttcgcgcct gtctcgctgc tttcgataag tctctagcca tttaaaattt     7020

ttgatgacct gctgcgacgc tttttttctg gcaagatagt cttgtaaatg cgggccaaga     7080

tctgcacact ggtatttcgg tttttggggc cgcgggcggc gacggggccc gtgcgtccca     7140

gcgcacatgt tcggcgaggc ggggcctgcg agcgcggcca ccgagaatcg gacgggggta     7200

gtctcaagct ggccggcctg ctctggtgcc tggcctcgcg ccgccgtgta tcgccccgcc     7260

ctgggcggca aggctggccc ggtcggcacc agttgcgtga gcggaaagat ggccgcttcc     7320

cggccctgct gcagggagct caaaatggag gacgcggcgc tcgggagagc gggcgggtga     7380

gtcacccaca caaaggaaaa gggcctttcc gtcctcagcc gtcgcttcat gtgactccac     7440

tgagtaccgg gcgccgtcca ggcacctcga ttagttctcg tgcttttgga gtacgtcgtc     7500

tttaggttgg ggggaggggt tttatgcgat ggagtttccc cacactgagt gggtggagac     7560

tgaagttagg ccagcttggc acttgatgta attctccttg gaatttgccc tttttgagtt     7620

tggatcttgg ttcattctca agcctcagac agtggttcaa agtttttttc ttccatttca     7680

ggtgtcgtga g                                                          7691


<210>  31
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
1               5                   10                  15      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
            20                  25                  30          


Cys Gln 
        


<210>  32
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
1               5                   10                  15      


Thr Leu Asn Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
            20                  25                  30          


Cys Gln 
        


<210>  33
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33

Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr 
1               5                   10                  15      


Tyr Cys Val Asn Gly Asn Pro Trp Leu Ala 
            20                  25      


<210>  34
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Asp Phe Tyr 
1               5                   10                  15      


Tyr Cys Val Asn Gly Asn Pro Trp Leu Ala 
            20                  25      


<210>  35
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Thr Ser Ser Gly 
                245     


<210>  36
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Val Lys Arg 
            


<210>  37
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
1               5                   10                  


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Thr Ser Ser Gly 
1               


<210>  39
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39

Ser Gly 
1       


<210>  40
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaag                   708


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41

Asp Tyr Asn Met His 
1               5   


<210>  42
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ser Lys Ala 
            


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln 
1               5                   10  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47

Gly Tyr Thr Ile Thr Asp Ser Asn 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48

Ile Tyr Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49

Val Asn Gly Asn Pro Trp Leu Ala Tyr 
1               5                   


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50

Glu Ser Leu Asp Asn Tyr Gly Ile Arg Phe 
1               5                   10  


<210>  51
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51

Ala Ala Ser 
1           


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52

Gln Gln Thr Lys Glu Val Pro Trp Ser 
1               5                   


