                         SEQUENCE LISTING

<110>  SURFACE ONCOLOGY, INC.
       ADIMAB LLC
       CHAPPEL, Scott et al.
 
<120>  ANTIBODIES THAT BIND CD39 AND USES THEREOF

<130>  01219-0003-00PCT

<150>  US 62/642,938
<151>  2018-03-14

<150>  US 62/803,235
<151>  2019-02-08

<160>  138   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (IMGT)

<400>  1

Gly Gly Thr Phe Ser Asp Lys Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (IMGT)

<400>  2

Ile Leu Pro Ile Phe Gly Thr Ala 
1               5               


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (IMGT)

<400>  3

Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu 
1               5                   10                  


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (ADI)

<400>  4

Gly Thr Phe Ser Asp Lys Ala Ile Ser 
1               5                   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (ADI)

<400>  5

Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (ADI)

<400>  6

Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu 
1               5                   10                  


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Lys 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VH

<400>  8
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc gataaggcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatcg atccttccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggagag gtaccttggt caccgtctcc      360

tca                                                                    363


<210>  9
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Lys 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  10
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  10
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc gataaggcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatcg atccttccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggagag gtaccttggt caccgtctcc      360

tcagcgagca ccaaaggccc gagcgtgttt ccgctggcgc cgagcagcaa aagcaccagc      420

ggcggcaccg cggcgctggg ctgcctggtg aaagattatt ttccggaacc ggtgaccgtg      480

agctggaaca gcggcgcgct gaccagcggc gtgcatacct ttccggcggt gctgcagagc      540

agcggcctgt atagcctgag cagcgtggtg accgtgccga gcagcagcct gggcacccag      600

acctatattt gcaacgtgaa ccataaaccg agcaacacca aagtggataa aaaagtggaa      660

ccgaaaagct gcgataaaac ccatacctgc ccgccgtgcc cggcgccgga actgctgggc      720

ggcccgagcg tgtttctgtt tccgccgaaa ccgaaagata ccctgatgat tagccgcacc      780

ccggaagtga cctgcgtggt ggtggatgtg agccatgaag atccggaagt gaaatttaac      840

tggtatgtgg atggcgtgga agtgcataac gcgaaaacca aaccgcgcga agaacagtat      900

aacagcacct atcgcgtggt gagcgtgctg accgtgctgc atcaggattg gctgaacggc      960

aaagaatata aatgcaaagt gagcaacaaa gcgctgccgg cgccgattga aaaaaccatt     1020

agcaaagcga aaggccagcc gcgcgaaccg caggtgtata ccctgccgcc gagccgcgat     1080

gaactgacca aaaaccaggt gagcctgacc tgcctggtga aaggctttta tccgagcgat     1140

attgcggtgg aatgggaaag caacggccag ccggaaaaca actataaaac caccccgccg     1200

gtgctggata gcgatggcag cttttttctg tatagcaaac tgaccgtgga taaaagccgc     1260

tggcagcagg gcaacgtgtt tagctgcagc gtgatgcatg aagcgctgca taaccattat     1320

acccagaaaa gcctgagcct gagcccgggc aaa                                  1353


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (IMGT)

<400>  11

Gln Ser Val Ser Ser Asn 
1               5       


<210>  12
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (IMGT)

<400>  12

Gly Ala Ser 
1           


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (IMGT)

<400>  13

Gln Gln His Ala Leu Trp Pro Leu Thr 
1               5                   


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (ADI)

<400>  14

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (ADI)

<400>  15

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (ADI)

<400>  16

Gln Gln His Ala Leu Trp Pro Leu Thr 
1               5                   


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL

<400>  17

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Ala Leu Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  18
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VL

<400>  18
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag cacgccctct ggcctctcac ttttggcgga      300

gggaccaagg ttgagatcaa a                                                321


<210>  19
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LIGHT CHAIN

<400>  19

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Ala Leu Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  20
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA LIGHT CHAIN

<400>  20
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag cacgccctct ggcctctcac ttttggcgga      300

gggaccaagg ttgagatcaa acgtacggtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtcgtgt gcctgctgaa caacttctac      420

cctcgcgagg ccaaagtgca gtggaaagtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtca ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  21
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Lys 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  22
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  22
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc gataaggcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatcg atccttccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggagag gtaccttggt caccgtctcc      360

tcagcttcca ccaagggccc ctccgtgttc cctctggccc cttgctcccg gtccacctcc      420

gagtctaccg ccgctctggg ctgcctcgtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaact ctggcgccct gacctccggc gtgcacacct tccctgccgt gctgcagtcc      540

tccggcctgt actccctgtc cagcgtcgtg accgtgccct cctccagcct gggcaccaag      600

acctacacct gtaacgtgga ccacaagccc tccaacacca aagtggacaa gcgggtggaa      660

tctaagtacg gccctccctg cccttcctgc cctgcccctg agttcctggg cggaccttcc      720

gtgttcctgt tccctccaaa gcccaaggac accctgatga tctcccggac ccctgaagtg      780

acctgcgtgg tggtggacgt gtcccaggaa gatcccgaag tccagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa cgccaagacc aagcccagag aggaacagtt caactccacc      900

taccgggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac      960

aagtgcaaag tgtccaacaa gggcctgccc tccagcatcg aaaagaccat ctccaaggcc     1020

aagggccagc cccgcgagcc ccaagtgtac accctgcctc ccagccagga agagatgacc     1080

aagaatcaag tgtccctgac ttgtctggtc aagggcttct acccctccga tatcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aactacaaga ccacccctcc cgtgctggac     1200

tccgacggct ccttcttcct gtactctcgg ctgaccgtgg acaagtcccg gtggcaggaa     1260

ggcaacgtct tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtccc tgtctctggg c                                               1341


<210>  23
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Lys 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  24
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  24
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc gataaggcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatcg atccttccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggagag gtaccttggt caccgtctcc      360

tcagcttcca ccaagggccc ctccgtgttc cctctggccc cttgctcccg gtccacctcc      420

gagtctaccg ccgctctggg ctgcctcgtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaact ctggcgccct gacctccggc gtgcacacct tccctgccgt gctgcagtcc      540

tccggcctgt actccctgtc cagcgtcgtg accgtgccct cctccagcct gggcaccaag      600

acctacacct gtaacgtgga ccacaagccc tccaacacca aagtggacaa gcgggtggaa      660

tctaagtacg gccctccctg ccctccttgc cctgcccctg agttcctggg cggaccttcc      720

gtgttcctgt tccctccaaa gcccaaggac accctgatga tctcccggac ccctgaagtg      780

acctgcgtgg tggtggacgt gtcccaggaa gatcccgaag tccagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa cgccaagacc aagcccagag aggaacagtt caactccacc      900

taccgggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac      960

aagtgcaaag tgtccaacaa gggcctgccc tccagcatcg aaaagaccat ctccaaggcc     1020

aagggccagc cccgcgagcc ccaagtgtac accctgcctc ccagccagga agagatgacc     1080

aagaatcaag tgtccctgac ttgtctggtc aagggcttct acccctccga tatcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aactacaaga ccacccctcc cgtgctggac     1200

tccgacggct ccttcttcct gtactctcgg ctgaccgtgg acaagtcccg gtggcaggaa     1260

ggcaacgtct tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtccc tgtctctggg c                                               1341


<210>  25
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Lys 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  26
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  26
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc gataaggcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatcg atccttccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggagag gtaccttggt caccgtctcc      360

tcagcttcca ccaagggccc ctccgtgttc cctctggccc cttgctcccg gtccacctcc      420

gagtctaccg ccgctctggg ctgcctcgtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaact ctggcgccct gacctccggc gtgcacacct tccctgccgt gctgcagtcc      540

tccggcctgt actccctgtc cagcgtcgtg accgtgccct cctccagcct gggcaccaag      600

acctacacct gtaacgtgga ccacaagccc tccaacacca aagtggacaa gcgggtggaa      660

tctaagtacg gccctccctg ccctccttgc cctgcccctg agttcgaggg cggaccttcc      720

gtgttcctgt tccctccaaa gcccaaggac accctgatga tctcccggac ccctgaagtg      780

acctgcgtgg tggtggacgt gtcccaggaa gatcccgaag tccagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa cgccaagacc aagcccagag aggaacagtt caactccacc      900

taccgggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac      960

aagtgcaaag tgtccaacaa gggcctgccc tccagcatcg aaaagaccat ctccaaggcc     1020

aagggccagc cccgcgagcc ccaagtgtac accctgcctc ccagccagga agagatgacc     1080

aagaatcaag tgtccctgac ttgtctggtc aagggcttct acccctccga tatcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aactacaaga ccacccctcc cgtgctggac     1200

tccgacggct ccttcttcct gtactctcgg ctgaccgtgg acaagtcccg gtggcaggaa     1260

ggcaacgtct tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtccc tgtctctggg c                                               1341


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (IMGT)

<400>  27

Gly Gly Thr Phe Ser Ser Glu Gly 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (IMGT)

<400>  28

Ile Leu Pro Ile Phe Gly Thr Ala 
1               5               


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (IMGT)

<400>  29

Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu 
1               5                   10                  


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (ADI)

<400>  30

Gly Thr Phe Ser Ser Glu Gly Ile Ser 
1               5                   


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (ADI)

<400>  31

Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (ADI)

<400>  32

Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu 
1               5                   10                  


<210>  33
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Glu 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  34
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VH

<400>  34
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agcgagggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagt atcttgccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggaaag gtaccttggt caccgtctcc      360

tca                                                                    363


<210>  35
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Glu 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  36
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  36
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agcgagggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagt atcttgccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggaaag gtaccttggt caccgtctcc      360

tcagcgagca ccaaaggccc gagcgtgttt ccgctggcgc cgagcagcaa aagcaccagc      420

ggcggcaccg cggcgctggg ctgcctggtg aaagattatt ttccggaacc ggtgaccgtg      480

agctggaaca gcggcgcgct gaccagcggc gtgcatacct ttccggcggt gctgcagagc      540

agcggcctgt atagcctgag cagcgtggtg accgtgccga gcagcagcct gggcacccag      600

acctatattt gcaacgtgaa ccataaaccg agcaacacca aagtggataa aaaagtggaa      660

ccgaaaagct gcgataaaac ccatacctgc ccgccgtgcc cggcgccgga actgctgggc      720

ggcccgagcg tgtttctgtt tccgccgaaa ccgaaagata ccctgatgat tagccgcacc      780

ccggaagtga cctgcgtggt ggtggatgtg agccatgaag atccggaagt gaaatttaac      840

tggtatgtgg atggcgtgga agtgcataac gcgaaaacca aaccgcgcga agaacagtat      900

aacagcacct atcgcgtggt gagcgtgctg accgtgctgc atcaggattg gctgaacggc      960

aaagaatata aatgcaaagt gagcaacaaa gcgctgccgg cgccgattga aaaaaccatt     1020

agcaaagcga aaggccagcc gcgcgaaccg caggtgtata ccctgccgcc gagccgcgat     1080

gaactgacca aaaaccaggt gagcctgacc tgcctggtga aaggctttta tccgagcgat     1140

attgcggtgg aatgggaaag caacggccag ccggaaaaca actataaaac caccccgccg     1200

gtgctggata gcgatggcag cttttttctg tatagcaaac tgaccgtgga taaaagccgc     1260

tggcagcagg gcaacgtgtt tagctgcagc gtgatgcatg aagcgctgca taaccattat     1320

acccagaaaa gcctgagcct gagcccgggc aaa                                  1353


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (IMGT)

<400>  37

Gln Ser Val Ser Ser Asn 
1               5       


<210>  38
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (IMGT)

<400>  38

Gly Ala Ser 
1           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (IMGT)

<400>  39

Gln Gln His Ala Leu Trp Pro Leu Thr 
1               5                   


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (ADI)

<400>  40

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (ADI)

<400>  41

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (ADI)

<400>  42

Gln Gln His Ala Leu Trp Pro Leu Thr 
1               5                   


<210>  43
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL

<400>  43

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Ala Leu Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  44
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VL

<400>  44
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag cacgccctct ggcctctcac ttttggcgga      300

gggaccaagg ttgagatcaa a                                                321


<210>  45
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LIGHT CHAIN

<400>  45

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Ala Leu Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  46
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA LIGHT CHAIN

<400>  46
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag cacgccctct ggcctctcac ttttggcgga      300

gggaccaagg ttgagatcaa acgtacggtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtcgtgt gcctgctgaa caacttctac      420

cctcgcgagg ccaaagtgca gtggaaagtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtca ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  47
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Glu 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  48
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  48
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agcgagggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagt atcttgccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggaaag gtaccttggt caccgtctcc      360

tcagcttcca ccaagggccc ctccgtgttc cctctggccc cttgctcccg gtccacctcc      420

gagtctaccg ccgctctggg ctgcctcgtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaact ctggcgccct gacctccggc gtgcacacct tccctgccgt gctgcagtcc      540

tccggcctgt actccctgtc cagcgtcgtg accgtgccct cctccagcct gggcaccaag      600

acctacacct gtaacgtgga ccacaagccc tccaacacca aagtggacaa gcgggtggaa      660

tctaagtacg gccctccctg cccttcctgc cctgcccctg agttcctggg cggaccttcc      720

gtgttcctgt tccctccaaa gcccaaggac accctgatga tctcccggac ccctgaagtg      780

acctgcgtgg tggtggacgt gtcccaggaa gatcccgaag tccagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa cgccaagacc aagcccagag aggaacagtt caactccacc      900

taccgggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac      960

aagtgcaaag tgtccaacaa gggcctgccc tccagcatcg aaaagaccat ctccaaggcc     1020

aagggccagc cccgcgagcc ccaagtgtac accctgcctc ccagccagga agagatgacc     1080

aagaatcaag tgtccctgac ttgtctggtc aagggcttct acccctccga tatcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aactacaaga ccacccctcc cgtgctggac     1200

tccgacggct ccttcttcct gtactctcgg ctgaccgtgg acaagtcccg gtggcaggaa     1260

ggcaacgtct tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtccc tgtctctggg c                                               1341


<210>  49
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Glu 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  50
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  50
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agcgagggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagt atcttgccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggaaag gtaccttggt caccgtctcc      360

tcagcttcca ccaagggccc ctccgtgttc cctctggccc cttgctcccg gtccacctcc      420

gagtctaccg ccgctctggg ctgcctcgtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaact ctggcgccct gacctccggc gtgcacacct tccctgccgt gctgcagtcc      540

tccggcctgt actccctgtc cagcgtcgtg accgtgccct cctccagcct gggcaccaag      600

acctacacct gtaacgtgga ccacaagccc tccaacacca aagtggacaa gcgggtggaa      660

tctaagtacg gccctccctg ccctccttgc cctgcccctg agttcctggg cggaccttcc      720

gtgttcctgt tccctccaaa gcccaaggac accctgatga tctcccggac ccctgaagtg      780

acctgcgtgg tggtggacgt gtcccaggaa gatcccgaag tccagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa cgccaagacc aagcccagag aggaacagtt caactccacc      900

taccgggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac      960

aagtgcaaag tgtccaacaa gggcctgccc tccagcatcg aaaagaccat ctccaaggcc     1020

aagggccagc cccgcgagcc ccaagtgtac accctgcctc ccagccagga agagatgacc     1080

aagaatcaag tgtccctgac ttgtctggtc aagggcttct acccctccga tatcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aactacaaga ccacccctcc cgtgctggac     1200

tccgacggct ccttcttcct gtactctcgg ctgaccgtgg acaagtcccg gtggcaggaa     1260

ggcaacgtct tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtccc tgtctctggg c                                               1341


<210>  51
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Glu 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Leu Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Tyr Arg Tyr Arg Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  52
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  52
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agcgagggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagt atcttgccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaagcc      300

ggatactacc gctaccgata cttcgaccta tgggggaaag gtaccttggt caccgtctcc      360

tcagcttcca ccaagggccc ctccgtgttc cctctggccc cttgctcccg gtccacctcc      420

gagtctaccg ccgctctggg ctgcctcgtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaact ctggcgccct gacctccggc gtgcacacct tccctgccgt gctgcagtcc      540

tccggcctgt actccctgtc cagcgtcgtg accgtgccct cctccagcct gggcaccaag      600

acctacacct gtaacgtgga ccacaagccc tccaacacca aagtggacaa gcgggtggaa      660

tctaagtacg gccctccctg ccctccttgc cctgcccctg agttcgaggg cggaccttcc      720

gtgttcctgt tccctccaaa gcccaaggac accctgatga tctcccggac ccctgaagtg      780

acctgcgtgg tggtggacgt gtcccaggaa gatcccgaag tccagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa cgccaagacc aagcccagag aggaacagtt caactccacc      900

taccgggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac      960

aagtgcaaag tgtccaacaa gggcctgccc tccagcatcg aaaagaccat ctccaaggcc     1020

aagggccagc cccgcgagcc ccaagtgtac accctgcctc ccagccagga agagatgacc     1080

aagaatcaag tgtccctgac ttgtctggtc aagggcttct acccctccga tatcgccgtg     1140

gagtgggagt ccaacggcca gcccgagaac aactacaaga ccacccctcc cgtgctggac     1200

tccgacggct ccttcttcct gtactctcgg ctgaccgtgg acaagtcccg gtggcaggaa     1260

ggcaacgtct tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtccc tgtctctggg c                                               1341


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (IMGT)

<400>  53

Gly Gly Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (IMGT)

<400>  54

Ile Ile Pro Ala Phe Gly Thr Ala 
1               5               


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (IMGT)

<400>  55

Ala Arg Asp Pro Val Arg Arg Ser Pro Phe Asp Ile 
1               5                   10          


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (ADI)

<400>  56

Gly Thr Phe Ser Thr Tyr Ala Ile Gly 
1               5                   


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (ADI)

<400>  57

Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (ADI)

<400>  58

Ala Arg Asp Pro Val Arg Arg Ser Pro Phe Asp Ile 
1               5                   10          


<210>  59
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Val Arg Arg Ser Pro Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  60
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VH

<400>  60
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc acgtatgcta tcgggtgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cgtttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatccg      300

gtgagaagaa gcccattcga catatggggt cagggtacaa tggtcaccgt ctcctca         357


<210>  61
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  61

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Val Arg Arg Ser Pro Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  62
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  62
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc acgtatgcta tcgggtgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cgtttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatccg      300

gtgagaagaa gcccattcga catatggggt cagggtacaa tggtcaccgt ctcctcagcg      360

agcaccaaag gcccgagcgt gtttccgctg gcgccgagca gcaaaagcac cagcggcggc      420

accgcggcgc tgggctgcct ggtgaaagat tattttccgg aaccggtgac cgtgagctgg      480

aacagcggcg cgctgaccag cggcgtgcat acctttccgg cggtgctgca gagcagcggc      540

ctgtatagcc tgagcagcgt ggtgaccgtg ccgagcagca gcctgggcac ccagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agctgcgata aaacccatac ctgcccgccg tgcccggcgc cggaactgct gggcggcccg      720

agcgtgtttc tgtttccgcc gaaaccgaaa gataccctga tgattagccg caccccggaa      780

gtgacctgcg tggtggtgga tgtgagccat gaagatccgg aagtgaaatt taactggtat      840

gtggatggcg tggaagtgca taacgcgaaa accaaaccgc gcgaagaaca gtataacagc      900

acctatcgcg tggtgagcgt gctgaccgtg ctgcatcagg attggctgaa cggcaaagaa      960

tataaatgca aagtgagcaa caaagcgctg ccggcgccga ttgaaaaaac cattagcaaa     1020

gcgaaaggcc agccgcgcga accgcaggtg tataccctgc cgccgagccg cgatgaactg     1080

accaaaaacc aggtgagcct gacctgcctg gtgaaaggct tttatccgag cgatattgcg     1140

gtggaatggg aaagcaacgg ccagccggaa aacaactata aaaccacccc gccggtgctg     1200

gatagcgatg gcagcttttt tctgtatagc aaactgaccg tggataaaag ccgctggcag     1260

cagggcaacg tgtttagctg cagcgtgatg catgaagcgc tgcataacca ttatacccag     1320

aaaagcctga gcctgagccc gggcaaa                                         1347


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (IMGT)

<400>  63

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  64
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (IMGT)

<400>  64

Asp Ser Ser 
1           


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (IMGT)

<400>  65

Gln Gln Ser Phe Leu Trp Pro Arg Thr 
1               5                   


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (ADI)

<400>  66

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (ADI)

<400>  67

Asp Ser Ser Asn Arg Ala Thr 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (ADI)

<400>  68

Gln Gln Ser Phe Leu Trp Pro Arg Thr 
1               5                   


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL

<400>  69

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ser Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Phe Leu Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VL

<400>  70
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat tcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag tccttcctct ggcctaggac ttttggcgga      300

gggaccaagg ttgagatcaa a                                                321


<210>  71
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LIGHT CHAIN

<400>  71

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ser Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Phe Leu Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  72
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA LIGHT CHAIN

<400>  72
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat tcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag tccttcctct ggcctaggac ttttggcgga      300

gggaccaagg ttgagatcaa acgtacggtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtcgtgt gcctgctgaa caacttctac      420

cctcgcgagg ccaaagtgca gtggaaagtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtca ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  73
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Val Arg Arg Ser Pro Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  74
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  74
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc acgtatgcta tcgggtgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cgtttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatccg      300

gtgagaagaa gcccattcga catatggggt cagggtacaa tggtcaccgt ctcctcagct      360

tccaccaagg gcccctccgt gttccctctg gccccttgct cccggtccac ctccgagtct      420

accgccgctc tgggctgcct cgtgaaggac tacttccccg agcccgtgac cgtgtcctgg      480

aactctggcg ccctgacctc cggcgtgcac accttccctg ccgtgctgca gtcctccggc      540

ctgtactccc tgtccagcgt cgtgaccgtg ccctcctcca gcctgggcac caagacctac      600

acctgtaacg tggaccacaa gccctccaac accaaagtgg acaagcgggt ggaatctaag      660

tacggccctc cctgcccttc ctgccctgcc cctgagttcc tgggcggacc ttccgtgttc      720

ctgttccctc caaagcccaa ggacaccctg atgatctccc ggacccctga agtgacctgc      780

gtggtggtgg acgtgtccca ggaagatccc gaagtccagt tcaattggta cgtggacggc      840

gtggaagtgc acaacgccaa gaccaagccc agagaggaac agttcaactc cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc      960

aaagtgtcca acaagggcct gccctccagc atcgaaaaga ccatctccaa ggccaagggc     1020

cagccccgcg agccccaagt gtacaccctg cctcccagcc aggaagagat gaccaagaat     1080

caagtgtccc tgacttgtct ggtcaagggc ttctacccct ccgatatcgc cgtggagtgg     1140

gagtccaacg gccagcccga gaacaactac aagaccaccc ctcccgtgct ggactccgac     1200

ggctccttct tcctgtactc tcggctgacc gtggacaagt cccggtggca ggaaggcaac     1260

gtcttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1320

tccctgtctc tgggc                                                      1335


<210>  75
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Val Arg Arg Ser Pro Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  76
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  76
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc acgtatgcta tcgggtgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cgtttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatccg      300

gtgagaagaa gcccattcga catatggggt cagggtacaa tggtcaccgt ctcctcagct      360

tccaccaagg gcccctccgt gttccctctg gccccttgct cccggtccac ctccgagtct      420

accgccgctc tgggctgcct cgtgaaggac tacttccccg agcccgtgac cgtgtcctgg      480

aactctggcg ccctgacctc cggcgtgcac accttccctg ccgtgctgca gtcctccggc      540

ctgtactccc tgtccagcgt cgtgaccgtg ccctcctcca gcctgggcac caagacctac      600

acctgtaacg tggaccacaa gccctccaac accaaagtgg acaagcgggt ggaatctaag      660

tacggccctc cctgccctcc ttgccctgcc cctgagttcc tgggcggacc ttccgtgttc      720

ctgttccctc caaagcccaa ggacaccctg atgatctccc ggacccctga agtgacctgc      780

gtggtggtgg acgtgtccca ggaagatccc gaagtccagt tcaattggta cgtggacggc      840

gtggaagtgc acaacgccaa gaccaagccc agagaggaac agttcaactc cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc      960

aaagtgtcca acaagggcct gccctccagc atcgaaaaga ccatctccaa ggccaagggc     1020

cagccccgcg agccccaagt gtacaccctg cctcccagcc aggaagagat gaccaagaat     1080

caagtgtccc tgacttgtct ggtcaagggc ttctacccct ccgatatcgc cgtggagtgg     1140

gagtccaacg gccagcccga gaacaactac aagaccaccc ctcccgtgct ggactccgac     1200

ggctccttct tcctgtactc tcggctgacc gtggacaagt cccggtggca ggaaggcaac     1260

gtcttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1320

tccctgtctc tgggc                                                      1335


<210>  77
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Val Arg Arg Ser Pro Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  78
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  78
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc acgtatgcta tcgggtgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cgtttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatccg      300

gtgagaagaa gcccattcga catatggggt cagggtacaa tggtcaccgt ctcctcagct      360

tccaccaagg gcccctccgt gttccctctg gccccttgct cccggtccac ctccgagtct      420

accgccgctc tgggctgcct cgtgaaggac tacttccccg agcccgtgac cgtgtcctgg      480

aactctggcg ccctgacctc cggcgtgcac accttccctg ccgtgctgca gtcctccggc      540

ctgtactccc tgtccagcgt cgtgaccgtg ccctcctcca gcctgggcac caagacctac      600

acctgtaacg tggaccacaa gccctccaac accaaagtgg acaagcgggt ggaatctaag      660

tacggccctc cctgccctcc ttgccctgcc cctgagttcg agggcggacc ttccgtgttc      720

ctgttccctc caaagcccaa ggacaccctg atgatctccc ggacccctga agtgacctgc      780

gtggtggtgg acgtgtccca ggaagatccc gaagtccagt tcaattggta cgtggacggc      840

gtggaagtgc acaacgccaa gaccaagccc agagaggaac agttcaactc cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc      960

aaagtgtcca acaagggcct gccctccagc atcgaaaaga ccatctccaa ggccaagggc     1020

cagccccgcg agccccaagt gtacaccctg cctcccagcc aggaagagat gaccaagaat     1080

caagtgtccc tgacttgtct ggtcaagggc ttctacccct ccgatatcgc cgtggagtgg     1140

gagtccaacg gccagcccga gaacaactac aagaccaccc ctcccgtgct ggactccgac     1200

ggctccttct tcctgtactc tcggctgacc gtggacaagt cccggtggca ggaaggcaac     1260

gtcttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1320

tccctgtctc tgggc                                                      1335


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (IMGT)

<400>  79

Gly Phe Thr Phe Ser Ser Tyr Arg 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (IMGT)

<400>  80

Ile Ser Ser Ser Ser Ser Ser Ile 
1               5               


<210>  81
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (IMGT)

<400>  81

Ala Lys Gly Pro Arg Tyr Asp Ser Ser Gly Tyr Arg Trp Arg Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (ADI)

<400>  82

Phe Thr Phe Ser Ser Tyr Arg Met Asn 
1               5                   


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (ADI)

<400>  83

Ser Ile Ser Ser Ser Ser Ser Ser Ile Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (ADI)

<400>  84

Ala Lys Gly Pro Arg Tyr Asp Ser Ser Gly Tyr Arg Trp Arg Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  85
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Ser Ile Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Tyr Asp Ser Ser Gly Tyr Arg Trp Arg Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  86
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VH

<400>  86
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttctct agctatagga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagttc gatatggtac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc caagggcccc      300

agatacgaca gcagcggata ccgatggaga tacggaatgg acgtatgggg ccagggaaca      360

actgtcaccg tctcctca                                                    378


<210>  87
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Ser Ile Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Tyr Asp Ser Ser Gly Tyr Arg Trp Arg Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  88
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  88
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttctct agctatagga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagttc gatatggtac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc caagggcccc      300

agatacgaca gcagcggata ccgatggaga tacggaatgg acgtatgggg ccagggaaca      360

actgtcaccg tctcctcagc gagcaccaaa ggcccgagcg tgtttccgct ggcgccgagc      420

agcaaaagca ccagcggcgg caccgcggcg ctgggctgcc tggtgaaaga ttattttccg      480

gaaccggtga ccgtgagctg gaacagcggc gcgctgacca gcggcgtgca tacctttccg      540

gcggtgctgc agagcagcgg cctgtatagc ctgagcagcg tggtgaccgt gccgagcagc      600

agcctgggca cccagaccta tatttgcaac gtgaaccata aaccgagcaa caccaaagtg      660

gataaaaaag tggaaccgaa aagctgcgat aaaacccata cctgcccgcc gtgcccggcg      720

ccggaactgc tgggcggccc gagcgtgttt ctgtttccgc cgaaaccgaa agataccctg      780

atgattagcc gcaccccgga agtgacctgc gtggtggtgg atgtgagcca tgaagatccg      840

gaagtgaaat ttaactggta tgtggatggc gtggaagtgc ataacgcgaa aaccaaaccg      900

cgcgaagaac agtataacag cacctatcgc gtggtgagcg tgctgaccgt gctgcatcag      960

gattggctga acggcaaaga atataaatgc aaagtgagca acaaagcgct gccggcgccg     1020

attgaaaaaa ccattagcaa agcgaaaggc cagccgcgcg aaccgcaggt gtataccctg     1080

ccgccgagcc gcgatgaact gaccaaaaac caggtgagcc tgacctgcct ggtgaaaggc     1140

ttttatccga gcgatattgc ggtggaatgg gaaagcaacg gccagccgga aaacaactat     1200

aaaaccaccc cgccggtgct ggatagcgat ggcagctttt ttctgtatag caaactgacc     1260

gtggataaaa gccgctggca gcagggcaac gtgtttagct gcagcgtgat gcatgaagcg     1320

ctgcataacc attataccca gaaaagcctg agcctgagcc cgggcaaa                  1368


<210>  89
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (IMGT)

<400>  89

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  90
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (IMGT)

<400>  90

Ala Ala Ser 
1           


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (IMGT)

<400>  91

Gln Gln Leu Tyr Val Asp Pro Pro Trp Thr 
1               5                   10  


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (ADI)

<400>  92

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (ADI)

<400>  93

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (ADI)

<400>  94

Gln Gln Leu Tyr Val Asp Pro Pro Trp Thr 
1               5                   10  


<210>  95
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Val Asp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  96
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VL

<400>  96
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcaa ctatacgtcg accctccttg gacttttggc      300

ggagggacca aggttgagat caaa                                             324


<210>  97
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LIGHT CHAIN

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Val Asp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  98
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA LIGHT CHAIN

<400>  98
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcaa ctatacgtcg accctccttg gacttttggc      300

ggagggacca aggttgagat caaacgtacg gtggccgctc cctccgtgtt catcttccca      360

ccctccgacg agcagctgaa gtccggcacc gcctccgtcg tgtgcctgct gaacaacttc      420

taccctcgcg aggccaaagt gcagtggaaa gtggacaacg ccctgcagtc cggcaactcc      480

caggaatccg tcaccgagca ggactccaag gacagcacct actccctgtc ctccaccctg      540

accctgtcca aggccgacta cgagaagcac aaagtgtacg cctgcgaagt gacccaccag      600

ggcctgtcca gccccgtgac caagtccttc aaccggggcg agtgc                      645


<210>  99
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Ser Ile Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Tyr Asp Ser Ser Gly Tyr Arg Trp Arg Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Leu Gly 
    450         


<210>  100
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  100
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttctct agctatagga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagttc gatatggtac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc caagggcccc      300

agatacgaca gcagcggata ccgatggaga tacggaatgg acgtatgggg ccagggaaca      360

actgtcaccg tctcctcagc ttccaccaag ggcccctccg tgttccctct ggccccttgc      420

tcccggtcca cctccgagtc taccgccgct ctgggctgcc tcgtgaagga ctacttcccc      480

gagcccgtga ccgtgtcctg gaactctggc gccctgacct ccggcgtgca caccttccct      540

gccgtgctgc agtcctccgg cctgtactcc ctgtccagcg tcgtgaccgt gccctcctcc      600

agcctgggca ccaagaccta cacctgtaac gtggaccaca agccctccaa caccaaagtg      660

gacaagcggg tggaatctaa gtacggccct ccctgccctt cctgccctgc ccctgagttc      720

ctgggcggac cttccgtgtt cctgttccct ccaaagccca aggacaccct gatgatctcc      780

cggacccctg aagtgacctg cgtggtggtg gacgtgtccc aggaagatcc cgaagtccag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc cagagaggaa      900

cagttcaact ccacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaagggcc tgccctccag catcgaaaag     1020

accatctcca aggccaaggg ccagccccgc gagccccaag tgtacaccct gcctcccagc     1080

caggaagaga tgaccaagaa tcaagtgtcc ctgacttgtc tggtcaaggg cttctacccc     1140

tccgatatcg ccgtggagtg ggagtccaac ggccagcccg agaacaacta caagaccacc     1200

cctcccgtgc tggactccga cggctccttc ttcctgtact ctcggctgac cgtggacaag     1260

tcccggtggc aggaaggcaa cgtcttctcc tgctccgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gtccctgtct ctgggc                               1356


<210>  101
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Ser Ile Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Tyr Asp Ser Ser Gly Tyr Arg Trp Arg Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Leu Gly 
    450         


<210>  102
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  102
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttctct agctatagga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagttc gatatggtac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc caagggcccc      300

agatacgaca gcagcggata ccgatggaga tacggaatgg acgtatgggg ccagggaaca      360

actgtcaccg tctcctcagc ttccaccaag ggcccctccg tgttccctct ggccccttgc      420

tcccggtcca cctccgagtc taccgccgct ctgggctgcc tcgtgaagga ctacttcccc      480

gagcccgtga ccgtgtcctg gaactctggc gccctgacct ccggcgtgca caccttccct      540

gccgtgctgc agtcctccgg cctgtactcc ctgtccagcg tcgtgaccgt gccctcctcc      600

agcctgggca ccaagaccta cacctgtaac gtggaccaca agccctccaa caccaaagtg      660

gacaagcggg tggaatctaa gtacggccct ccctgccctc cttgccctgc ccctgagttc      720

ctgggcggac cttccgtgtt cctgttccct ccaaagccca aggacaccct gatgatctcc      780

cggacccctg aagtgacctg cgtggtggtg gacgtgtccc aggaagatcc cgaagtccag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc cagagaggaa      900

cagttcaact ccacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaagggcc tgccctccag catcgaaaag     1020

accatctcca aggccaaggg ccagccccgc gagccccaag tgtacaccct gcctcccagc     1080

caggaagaga tgaccaagaa tcaagtgtcc ctgacttgtc tggtcaaggg cttctacccc     1140

tccgatatcg ccgtggagtg ggagtccaac ggccagcccg agaacaacta caagaccacc     1200

cctcccgtgc tggactccga cggctccttc ttcctgtact ctcggctgac cgtggacaag     1260

tcccggtggc aggaaggcaa cgtcttctcc tgctccgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gtccctgtct ctgggc                               1356


<210>  103
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Ser Ile Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Tyr Asp Ser Ser Gly Tyr Arg Trp Arg Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Leu Gly 
    450         


<210>  104
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  104
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttctct agctatagga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagttc gatatggtac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc caagggcccc      300

agatacgaca gcagcggata ccgatggaga tacggaatgg acgtatgggg ccagggaaca      360

actgtcaccg tctcctcagc ttccaccaag ggcccctccg tgttccctct ggccccttgc      420

tcccggtcca cctccgagtc taccgccgct ctgggctgcc tcgtgaagga ctacttcccc      480

gagcccgtga ccgtgtcctg gaactctggc gccctgacct ccggcgtgca caccttccct      540

gccgtgctgc agtcctccgg cctgtactcc ctgtccagcg tcgtgaccgt gccctcctcc      600

agcctgggca ccaagaccta cacctgtaac gtggaccaca agccctccaa caccaaagtg      660

gacaagcggg tggaatctaa gtacggccct ccctgccctc cttgccctgc ccctgagttc      720

gagggcggac cttccgtgtt cctgttccct ccaaagccca aggacaccct gatgatctcc      780

cggacccctg aagtgacctg cgtggtggtg gacgtgtccc aggaagatcc cgaagtccag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc cagagaggaa      900

cagttcaact ccacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaagggcc tgccctccag catcgaaaag     1020

accatctcca aggccaaggg ccagccccgc gagccccaag tgtacaccct gcctcccagc     1080

caggaagaga tgaccaagaa tcaagtgtcc ctgacttgtc tggtcaaggg cttctacccc     1140

tccgatatcg ccgtggagtg ggagtccaac ggccagcccg agaacaacta caagaccacc     1200

cctcccgtgc tggactccga cggctccttc ttcctgtact ctcggctgac cgtggacaag     1260

tcccggtggc aggaaggcaa cgtcttctcc tgctccgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gtccctgtct ctgggc                               1356


<210>  105
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (IMGT)

<400>  105

Gly Tyr Thr Phe Ser Ser Trp Tyr 
1               5               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (IMGT)

<400>  106

Ile Asn Pro Ser Gly Gly Ser Thr 
1               5               


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (IMGT)

<400>  107

Ala Arg Asp Ala Pro Phe Tyr Thr Trp Asp His Tyr Tyr Gly Met Asp 
1               5                   10                  15      


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1 (ADI)

<400>  108

Tyr Thr Phe Ser Ser Trp Tyr Met His 
1               5                   


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2 (ADI)

<400>  109

Met Ile Asn Pro Ser Gly Gly Ser Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3 (ADI)

<400>  110

Ala Arg Asp Ala Pro Phe Tyr Thr Trp Asp His Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  111
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VH

<400>  111

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Trp 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asn Pro Ser Gly Gly Ser Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Pro Phe Tyr Thr Trp Asp His Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  112
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VH

<400>  112
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcagt agctggtata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatg atcaacccta gtggtggtag cacaaagtac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatgct      300

cctttctaca cctgggatca ctactacgga atggacgtat ggggccaggg aacaactgtc      360

accgtctcct ca                                                          372


<210>  113
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  113

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Trp 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asn Pro Ser Gly Gly Ser Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Pro Phe Tyr Thr Trp Asp His Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  114
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  114
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcagt agctggtata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatg atcaacccta gtggtggtag cacaaagtac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatgct      300

cctttctaca cctgggatca ctactacgga atggacgtat ggggccaggg aacaactgtc      360

accgtctcct cagcgagcac caaaggcccg agcgtgtttc cgctggcgcc gagcagcaaa      420

agcaccagcg gcggcaccgc ggcgctgggc tgcctggtga aagattattt tccggaaccg      480

gtgaccgtga gctggaacag cggcgcgctg accagcggcg tgcatacctt tccggcggtg      540

ctgcagagca gcggcctgta tagcctgagc agcgtggtga ccgtgccgag cagcagcctg      600

ggcacccaga cctatatttg caacgtgaac cataaaccga gcaacaccaa agtggataaa      660

aaagtggaac cgaaaagctg cgataaaacc catacctgcc cgccgtgccc ggcgccggaa      720

ctgctgggcg gcccgagcgt gtttctgttt ccgccgaaac cgaaagatac cctgatgatt      780

agccgcaccc cggaagtgac ctgcgtggtg gtggatgtga gccatgaaga tccggaagtg      840

aaatttaact ggtatgtgga tggcgtggaa gtgcataacg cgaaaaccaa accgcgcgaa      900

gaacagtata acagcaccta tcgcgtggtg agcgtgctga ccgtgctgca tcaggattgg      960

ctgaacggca aagaatataa atgcaaagtg agcaacaaag cgctgccggc gccgattgaa     1020

aaaaccatta gcaaagcgaa aggccagccg cgcgaaccgc aggtgtatac cctgccgccg     1080

agccgcgatg aactgaccaa aaaccaggtg agcctgacct gcctggtgaa aggcttttat     1140

ccgagcgata ttgcggtgga atgggaaagc aacggccagc cggaaaacaa ctataaaacc     1200

accccgccgg tgctggatag cgatggcagc ttttttctgt atagcaaact gaccgtggat     1260

aaaagccgct ggcagcaggg caacgtgttt agctgcagcg tgatgcatga agcgctgcat     1320

aaccattata cccagaaaag cctgagcctg agcccgggca aa                        1362


<210>  115
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (IMGT)

<400>  115

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  116
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (IMGT)

<400>  116

Asp Ala Ser 
1           


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (IMGT)

<400>  117

Gln Gln Leu Tyr His Leu Pro Ile Thr 
1               5                   


<210>  118
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1 (ADI)

<400>  118

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2 (ADI)

<400>  119

Asp Ala Ser Asn Leu Ala Thr 
1               5           


<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3 (ADI)

<400>  120

Gln Gln Leu Tyr His Leu Pro Ile Thr 
1               5                   


<210>  121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VL

<400>  121

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Ala Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr His Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  122
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA VL

<400>  122
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggcaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcagcag ctctaccacc tccctatcac ttttggcgga      300

gggaccaagg ttgagatcaa a                                                321


<210>  123
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LIGHT CHAIN

<400>  123

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Ala Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr His Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  124
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA LIGHT CHAIN

<400>  124
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggcaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcagcag ctctaccacc tccctatcac ttttggcgga      300

gggaccaagg ttgagatcaa acgtacggtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtcgtgt gcctgctgaa caacttctac      420

cctcgcgagg ccaaagtgca gtggaaagtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtca ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  125
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  125

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Trp 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asn Pro Ser Gly Gly Ser Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Pro Phe Tyr Thr Trp Asp His Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly 
    450 


<210>  126
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  126
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcagt agctggtata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatg atcaacccta gtggtggtag cacaaagtac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatgct      300

cctttctaca cctgggatca ctactacgga atggacgtat ggggccaggg aacaactgtc      360

accgtctcct cagcttccac caagggcccc tccgtgttcc ctctggcccc ttgctcccgg      420

tccacctccg agtctaccgc cgctctgggc tgcctcgtga aggactactt ccccgagccc      480

gtgaccgtgt cctggaactc tggcgccctg acctccggcg tgcacacctt ccctgccgtg      540

ctgcagtcct ccggcctgta ctccctgtcc agcgtcgtga ccgtgccctc ctccagcctg      600

ggcaccaaga cctacacctg taacgtggac cacaagccct ccaacaccaa agtggacaag      660

cgggtggaat ctaagtacgg ccctccctgc ccttcctgcc ctgcccctga gttcctgggc      720

ggaccttccg tgttcctgtt ccctccaaag cccaaggaca ccctgatgat ctcccggacc      780

cctgaagtga cctgcgtggt ggtggacgtg tcccaggaag atcccgaagt ccagttcaat      840

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcccagaga ggaacagttc      900

aactccacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaagagtaca agtgcaaagt gtccaacaag ggcctgccct ccagcatcga aaagaccatc     1020

tccaaggcca agggccagcc ccgcgagccc caagtgtaca ccctgcctcc cagccaggaa     1080

gagatgacca agaatcaagt gtccctgact tgtctggtca agggcttcta cccctccgat     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca actacaagac cacccctccc     1200

gtgctggact ccgacggctc cttcttcctg tactctcggc tgaccgtgga caagtcccgg     1260

tggcaggaag gcaacgtctt ctcctgctcc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgtccct gtctctgggc                                      1350


<210>  127
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  127

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Trp 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asn Pro Ser Gly Gly Ser Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Pro Phe Tyr Thr Trp Asp His Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly 
    450 


<210>  128
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  128
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcagt agctggtata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatg atcaacccta gtggtggtag cacaaagtac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatgct      300

cctttctaca cctgggatca ctactacgga atggacgtat ggggccaggg aacaactgtc      360

accgtctcct cagcttccac caagggcccc tccgtgttcc ctctggcccc ttgctcccgg      420

tccacctccg agtctaccgc cgctctgggc tgcctcgtga aggactactt ccccgagccc      480

gtgaccgtgt cctggaactc tggcgccctg acctccggcg tgcacacctt ccctgccgtg      540

ctgcagtcct ccggcctgta ctccctgtcc agcgtcgtga ccgtgccctc ctccagcctg      600

ggcaccaaga cctacacctg taacgtggac cacaagccct ccaacaccaa agtggacaag      660

cgggtggaat ctaagtacgg ccctccctgc cctccttgcc ctgcccctga gttcctgggc      720

ggaccttccg tgttcctgtt ccctccaaag cccaaggaca ccctgatgat ctcccggacc      780

cctgaagtga cctgcgtggt ggtggacgtg tcccaggaag atcccgaagt ccagttcaat      840

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcccagaga ggaacagttc      900

aactccacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaagagtaca agtgcaaagt gtccaacaag ggcctgccct ccagcatcga aaagaccatc     1020

tccaaggcca agggccagcc ccgcgagccc caagtgtaca ccctgcctcc cagccaggaa     1080

gagatgacca agaatcaagt gtccctgact tgtctggtca agggcttcta cccctccgat     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca actacaagac cacccctccc     1200

gtgctggact ccgacggctc cttcttcctg tactctcggc tgaccgtgga caagtcccgg     1260

tggcaggaag gcaacgtctt ctcctgctcc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgtccct gtctctgggc                                      1350


<210>  129
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HEAVY CHAIN

<400>  129

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Trp 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asn Pro Ser Gly Gly Ser Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Pro Phe Tyr Thr Trp Asp His Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly 
    450 


<210>  130
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA HEAVY CHAIN

<400>  130
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcagt agctggtata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatg atcaacccta gtggtggtag cacaaagtac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatgct      300

cctttctaca cctgggatca ctactacgga atggacgtat ggggccaggg aacaactgtc      360

accgtctcct cagcttccac caagggcccc tccgtgttcc ctctggcccc ttgctcccgg      420

tccacctccg agtctaccgc cgctctgggc tgcctcgtga aggactactt ccccgagccc      480

gtgaccgtgt cctggaactc tggcgccctg acctccggcg tgcacacctt ccctgccgtg      540

ctgcagtcct ccggcctgta ctccctgtcc agcgtcgtga ccgtgccctc ctccagcctg      600

ggcaccaaga cctacacctg taacgtggac cacaagccct ccaacaccaa agtggacaag      660

cgggtggaat ctaagtacgg ccctccctgc cctccttgcc ctgcccctga gttcgagggc      720

ggaccttccg tgttcctgtt ccctccaaag cccaaggaca ccctgatgat ctcccggacc      780

cctgaagtga cctgcgtggt ggtggacgtg tcccaggaag atcccgaagt ccagttcaat      840

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcccagaga ggaacagttc      900

aactccacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaagagtaca agtgcaaagt gtccaacaag ggcctgccct ccagcatcga aaagaccatc     1020

tccaaggcca agggccagcc ccgcgagccc caagtgtaca ccctgcctcc cagccaggaa     1080

gagatgacca agaatcaagt gtccctgact tgtctggtca agggcttcta cccctccgat     1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca actacaagac cacccctccc     1200

gtgctggact ccgacggctc cttcttcctg tactctcggc tgaccgtgga caagtcccgg     1260

tggcaggaag gcaacgtctt ctcctgctcc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgtccct gtctctgggc                                      1350


<210>  131
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IgG1 Constant Region

<400>  131

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  132
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IgG4 Constant Region (terminal K absent)

<400>  132

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  133
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IgG4 Constant Region single mutant (S228P) (terminal K 
       absent)

<400>  133

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  134
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IgG4 Constant Region double mutant (S228P) (L235E) 
       (terminal K absent)

<400>  134

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: FLAG

<400>  135

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  136
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: polyhistidine (6-His)

<400>  136

His His His His His His 
1               5       


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hemagglutinin (HA)

<400>  137

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  138
<211>  510
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD39

<400>  138

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln 
65                  70                  75                  80  


Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln 
                85                  90                  95      


Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala 
            100                 105                 110         


Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu 
    130                 135                 140                 


Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys 
            180                 185                 190         


Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr 
        195                 200                 205             


Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val 
            260                 265                 270         


Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys 
        275                 280                 285             


Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg 
    290                 295                 300                 


Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly 
305                 310                 315                 320 


Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser 
                325                 330                 335     


Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro 
            340                 345                 350         


Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys 
        355                 360                 365             


Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu 
    370                 375                 380                 


Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser 
385                 390                 395                 400 


Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly 
                405                 410                 415     


Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp 
            420                 425                 430         


Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala 
        435                 440                 445             


Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala 
    450                 455                 460                 


Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu 
465                 470                 475                 480 


Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu 
                485                 490                 495     


Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
            500                 505                 510 


