                               SEQUENCE LISTING

<110> BAYLOR RESEARCH INSTITUTE
 
<120> METHODS AND COMPOSITIONS FOR TREATING, DIAGNOSING, AND PROGNOSING
      CANCER

<130> BHCS.P0612WO/1001060492

<140> PCT/US2019/022036
<141> 2019-03-13

<150> 62/642,312
<151> 2018-03-13

<160> 2     

<170> PatentIn version 3.5

<210> 1
<211> 11573
<212> DNA
<213> Homo sapiens

<400> 1
gcggtggcga aggcggcttt agtggcagca tgaagcgcac cccgactgcc gaggaacgag       60

agcgcgaagc taagaaactg aggcttcttg aagagcttga agacacttgg ctcccttatc      120

tgacccccaa agatgatgaa ttctatcagc agtggcagct gaaatatcct aaactaattc      180

tccgagaagc cagcagtgta tctgaggagc tccataaaga ggttcaagaa gcctttctca      240

cactgcacaa gcatggctgc ttatttcggg acctggttag gatccaaggc aaagatctgc      300

tcactccggt atctcgcatc ctcattggta atccaggctg cacctacaag tacctgaaca      360

ccaggctctt tacggtcccc tggccagtga aagggtctaa tataaaacac accgaggctg      420

aaatagccgc tgcttgtgag accttcctca agctcaatga ctacctgcag atagaaacca      480

tccaggcttt ggaagaactt gctgccaaag agaaggctaa tgaggatgct gtgccattgt      540

gtatgtctgc agatttcccc agggttggga tgggttcatc ctacaacgga caagatgaag      600

tggacattaa gagcagagca gcatacaacg taactttgct gaatttcatg gatcctcaga      660

aaatgccata cctgaaagag gaaccttatt ttggcatggg gaaaatggca gtgagctggc      720

atcatgatga aaatctggtg gacaggtcag cggtggcagt gtacagttat agctgtgaag      780

gccctgaaga ggaaagtgag gatgactctc atctcgaagg cagggatcct gatatttggc      840

atgttggttt taagatctca tgggacatag agacacctgg tttggcgata ccccttcacc      900

aaggagactg ctatttcatg cttgatgatc tcaatgccac ccaccaacac tgtgttttgg      960

ccggttcaca acctcggttt agttccaccc accgagtggc agagtgctca acaggaacct     1020

tggattatat tttacaacgc tgtcagttgg ctctgcagaa tgtctgtgac gatgtggaca     1080

atgatgatgt ctctttgaaa tcctttgagc ctgcagtttt gaaacaagga gaagaaattc     1140

ataatgaggt cgagtttgag tggctgaggc agttttggtt tcaaggcaat cgatacagaa     1200

agtgcactga ctggtggtgt caacccatgg ctcaactgga agcactgtgg aagaagatgg     1260

agggtgtgac aaatgctgtg cttcatgaag ttaaaagaga ggggctcccc gtggaacaaa     1320

ggaatgaaat cttgactgcc atccttgcct cgctcactgc acgccagaac ctgaggagag     1380

aatggcatgc caggtgccag tcacgaattg cccgaacatt acctgctgat cagaagccag     1440

aatgtcggcc atactgggaa aaggatgatg cttcgatgcc tctgccgttt gacctcacag     1500

acatcgtttc agaactcaga ggtcagcttc tggaagcaaa accctagaag gagcacaagt     1560

ctcaggcgga ggagaaaaag agatcggctt ttctcctcca acgttgtcat gggcttaagc     1620

aagagcagtg gagacttctc ttggccccta gattgtagca cccgggtccc aatccaaaac     1680

agctaggaaa tggtgcccat gaagttttaa atgttttaaa atgaccctgt gttatagtct     1740

gatttggtgt taaacaggac cttcttcccc caaaattgtt cagattataa aatgtgagcc     1800

attcagcccc caaggtccag ggcaggcgac aggaacgagc ccagcgtgtg acaaagccta     1860

acctactttc ctctttccca agctttttca gagactctgg agtggaccca gccctctggg     1920

gaaagacaga acttagagac atcccagtta ctcaccacac ccatagtgct gtccaatatg     1980

gtagccacta gctagctgtg gctacttcaa tttaaattca gttttaattt taattaaaaa     2040

tgcagctctt cagtcgccct ggccacattt caagtgctta acagcctcat gtggctagtg     2100

actgctgtat tggacggtac agatatggaa cattttcatc atcgaagaaa gtcctattgg     2160

acaacacttc tataaaaagt ttgagagcag gaattctcat ttccattcgt ctgtagcttc     2220

tatccccaaa ggcaaagaaa ctaaaagaga aatgactcat tgaagattgg cctctttcct     2280

ttctctaaga caaacctaag taaaagcctg agctttgagt cctatgctca gcacacggga     2340

aggagatgtt aataattaaa ataaagttga tatcctgtct ttagggagtt cccttgatct     2400

cttgaaagag acacagcccc atttacatta tttcgtggat ttcaccagca tagtatagtt     2460

tttttctgta agtccctcat tcttatgtaa taacaggtgg aactgaggtt tgaagaacct     2520

cagtggccca tcctgatgac attggagact caaagagaca agagagagta gggtttaaaa     2580

cctgagcttt aagactccca ctagcttcgt gtcctttggc atgttaacgt gcctcagttt     2640

cctcatctgt ataatgggga tatatgaaag gcaccagtcc taaggtgaac attaagtgag     2700

atgattctag ttacagactt agaacaattt ccagcacata gttaaatatc caggaaattc     2760

tggtactgtt atgtgtgggt gagctgacct ggatgtagat gttttcctct ctcttgctga     2820

cccctccgcc agttttgtct tgtgatgcca ttaacacatc tctccctttc tgacctggct     2880

cctgcccatt ggtgtcccaa gaaatcgtga gaatagttag ccccccgtct ccccagcctg     2940

ttgctttctc gtgtagttgt tcacagtagt tgagaagttg aagagctttt gcctattgaa     3000

ggtgcactga gaataaactc tttcctgcca ccagaattgc agtggttcac ggcctgcact     3060

cattcccatg aatgcagtta atagccacag aaatgtcaca ttaagcaaag cagccagggt     3120

ctcatcgtgt tgagactcga gtctctcaga ccttggattc attccctggt gtctttgagc     3180

ctcagtttcc tcattggtaa aagagaagtg aagcagtgtc tcacagggtc attacagaga     3240

ttaaatgaaa taaatgaaat aacatagacc aggagggcgt ggtgtttaaa agtcacagat     3300

ggggcaccct cgggccatcc agcccagtgt tttctttagc ccctatgatg ttcatttttt     3360

gttatatccc attaggtgcc catatttaaa aattgggaga tttcacataa aattaaaagg     3420

tctgcatttt cttttttctt ttcttttttt ttttttttga gacacagtct cactctgtca     3480

ccaggctaga gtgcagtggc acgatctcag ctcactgcaa cctctgcctc ccaggttcaa     3540

gtaattctcc tgcctcagcc tcccaagtag ctgggactac aggcacgtgc caccacgccc     3600

agctaatttt tgtattttta gcagagatgg ggtttcacca cattggccag gatggtctcg     3660

atctcaacct cgtgatccac ccacctcggt ctcccaaagc gctgggatta caggcgtgag     3720

ccaccgcgcc aagccaaggt ctgcattttt ctttagaact cagaacaccc aatagtccta     3780

ggcccccatc ctcgcatggc agcaagctaa ataagcatct tcccactgcg agttggggca     3840

tgacccagcc tatggtttgc catactccct ctttttctcc gttttttcat taattgtgaa     3900

cctgacctgc atcacccttt catgtcagtg ctctccaaac ctgcttgctt gcacccctct     3960

agtcgaaata ttttgtgctt accccaatat atgtgtgtga ctattgaact ctattcgtag     4020

actgcttgta ctaatgtcat ttgcatcata aaatattcat atccaataaa catattaaaa     4080

ggatgagata agaaaccgag agattttgct gtttttttcc ttttgcatgg atgagccagc     4140

ttcactgtcc tgggtggggc ccaggtggaa ttagttctca aagtcctcca ggtggagtca     4200

gggaatgtgc aacagggttg gagaaatcac tactttaagt gaatccgaaa ggtgagatca     4260

catttgctct aaagaaatgg tgatcccagc actttgggag gctgaggcag cagatcactg     4320

gaggtcagga gttcgagacc agcctggcca acacggtgaa accccgtctc tactgaaaac     4380

acaaaaatta gctgggtgtg gtggtgtgtg cctgtaatcc cagctactcg ggaggctgag     4440

gcaggcaaat cgcttggccc gggaggcgga ggttgcagtg agccgagatc atgccactgc     4500

actccagcct gggccacgga gcgagagaag aaagaaatgg tgactttcat tgatcatgtg     4560

tttgaggatt tcatgtgctc tccagggagg tttcaggtgg gtagaaggag gtgggcaaga     4620

cccaataaaa aagcagctgg tgcgggcaat gacaatgaac tcgtatcctg cagggtcaaa     4680

ggaaggcttg cttctgctgt gaattggaga aggactttcc tggaagcaca ggcccagaaa     4740

tcgcaccctt ctccccatgt gtgcggataa gggaccactt ccatcagcag cagccccctc     4800

ctgctttcct gccagtcctc cctgtggtcc caggtctctt gagaaaagtg atctaagaga     4860

tccctttgca atgaggtgct actgactgcc ctacctccct cccttcctcc catgaatgtt     4920

tcttggtgct gaccacagcc tcagcaatga ggcaagcctg gggacccaag acagatctct     4980

gcctcccagg ctagtggatg ccctgggata tgtagtcacc aaaataggaa cttaccccat     5040

agtggggaaa tagacagtaa gcagcaaatc aataacaaga gtgttccaga tggttgtaag     5100

tgccaggaag ggaaccaact gggagaggga caagaggaga tggtgactga ccaaggggac     5160

cttgatcagg ctgtggggaa gggaggtggt tgggaagagc ttcccaggaa aggggacggc     5220

gggcccaggc aggagagcct tgggaggggg tgcccaagga aggaaaaggg ccctgagcct     5280

gaagccgaga agaccaggag gggagaaggg gagatgtagg gcagagcaga cgggagccgc     5340

tcgggtttta ttccacacac cccaggaagc atgagagggt ttcaagcagc aagggcatgg     5400

aagtaacttg gtgagatatt tttatgcatt agatcatcgc tctatctgga ttccagaggg     5460

tctctgagag agcaaacagc ttaatccaaa ggagcggctt tccaactggg aatgtccccc     5520

tggctgggtg agatctcaag atggcctgcg gcccctctag attgcctgcc tacagagttc     5580

actctaaaca gcccctcccc tccacacccc agcagatcca ttcctgacgc cctcactggc     5640

aggctccagc cccacagagc tttctagaca taaaagagca gggtcatggc atcattggtg     5700

acacaatttt agtaataagc ttcaaaaccc atcactccac tgaatccagg gatgccagaa     5760

ttgagagtcc ataggacccg tttaacggat cccacattca gtagacggtt ttttgtatgc     5820

ttcgagggaa ggaaggtatt ttcaaatgca acttcttttt tttttttctt gctctagtta     5880

gggctgattt taccactggg caaattgcat acatttggat ccatgccacg ctaaaaactg     5940

tttattttgg agatctgtca gaggcaagca catggaagac aaggggattc tggtttgaaa     6000

aggcaattct catccagaca gattcagatg gagaggagcg gtgtggatta aaatgcgccg     6060

aagtggtaat gccgtttatc ccgtttgcct ttgttactct gtgattaaat ggtattttta     6120

attaagtttc attgggagcc ataggtatcg cggtggtgaa atcaatttga caaccataaa     6180

ggggagagac ggcacaggcg tgttgtgatg attgcggctg tagggaaagc cgggcagctt     6240

gcagaggatg ggtgggagga ggggaagccg gctaagaatg acttcctgca agacagcaag     6300

ggcacccctg ggccactgct gtgtttggga ggcaggtttt gggggttgtc agaaggcatt     6360

cacctggttc tctcgctcac ctgagacacc cgatagattc ctggaaactc caggaaagta     6420

tctgaagatc tggttctcca ttctctctta ttaacaagga gaaccacaag tgccccccag     6480

atcccggcta gaaggaccag acagctttcc accccggttc ccaggcagcc ctgctcccat     6540

agtcctgtgt cccatcggcc ccatgctccc aggacagtcc taattcccac ctctcagaac     6600

cttgtcagcc aagttcttcc tgctctctgg cccaaatcct cctcctacat tggaaactga     6660

gcctctctgc atcctctgct ctttctatcc cgctgtcatt catcagattt tccaaatctt     6720

tggattcctg agtggcagaa gaggttttct gagtttaagt tctgattctg tgtgtgattc     6780

tcactctacc acctcttcaa acctttgttg tcttatctac aaaatagaat agtagtaatc     6840

catcacctaa ggttgttgtg aaggttcaat aagttaatgc gtatttaaaa tgcctcccac     6900

agtacctgac atatactggg cttcagtgag gtactagcta ttattattaa ccaagtttcc     6960

tgtggtaaca gttgtagctt tgtgactggg ccaaatcact taacccctct gcgctccagt     7020

ctttgtttct ataatgggga tgatgataat gcctagctca ttggattgtt ctgtccccta     7080

cgatcagcca tgttaagtga ttcatatcat gtctggtact taaaaatcac gccacgcatg     7140

tacattatta tgatgaaaaa tatgatccgt gatatcctga ccaaaatatt aaagggacta     7200

aagatagctg tggcttgttc aagaagaata ttgtgtcact atcccatata ttatcccatt     7260

tgctcttcac agcttccatt tttcgctagg cggatggcat ggaacttttt ataaatgaga     7320

tattatgaaa aatgatgttt taggactctc atttctacag tgggagtagg tcacccattg     7380

caattttgga tttgcttaaa aaaattcttg ccatcacctt ctaatggatg atctgtgtac     7440

aacaattgtt tattgactct gaatgtctaa gtaccagggt cagtctattt caaggggagg     7500

gaagcattaa ttaacctcca gcattagatt cagtgattct tttccaatga tgcagttcat     7560

gactttgctc gcatttactt ttcatcaatc ctgaaagaat tgaggtaaaa tagttcctct     7620

gcacatgtgt gtcaagctaa atggataaca gcagatacag atctgtttgc ctgtctgcac     7680

ttgcctttag acaaaattca tcaattttac aaaagccact gactaaacat ggcaccaata     7740

caaatgaagc acttctagca ggcggagatt ccctttgttt ctgatctggt aaatgcggta     7800

gtttcctgct gagagatggg aagtgctggc ctaggacagc aaggtgccct acaggtgggg     7860

ccaaaagggt caagaccgtt ctacaggaag tttaggagaa gttcaatggt tccagatcct     7920

gtgtgcttcg ggtaattctg accctcttca ttagtgataa tggcatgaag ctctttcaca     7980

cagtcttttt tttttttctt tttttttttc agacagggtc tcaccctgtc acgtaggctg     8040

gagtgcagtg gtgagatcac ggctcactgc agcctcgact tcatgggctc aagcgattct     8100

cctgcctcag cctcctaagt agtcgggatc ataggcactt gccaccacat ccggctaatt     8160

tttttgtaga gacaggattt caccacatta cacaggctgg tttcaaactc cgaggctcaa     8220

gtgatctgcc tgcatcggcc tcccaaagcg ctgagattac aagcgtgagc cactacgcct     8280

tgccctccac acagccttgc ttggtgttaa agattaaaca aagaccacag gtgatcactg     8340

tcttcgtggt gccagtttca agggcaccct tcttcccttc ccagcctccg agagaaggag     8400

agagggtcca caagccagat ccatccccat ccacacaggt aaaaccacga ctgtgcagct     8460

agcaggtgga gataacattt ggaaaaaggc tttgtaaatg ctaaagtcct actcaagtcc     8520

aagggagaga aattattatt attcgttttg tgaaaccaat ttagtttggc tgggtaatgg     8580

aagaatttct acatacattc attacttctg atcaggcaag accagtctga cacaggaaca     8640

gtctatggct cactcttaaa gccacagcag gctgccaggg cttggagaaa tagaaacctc     8700

tcttgcacaa gaatagtctc aatgaatcat gttaaggcct ctttaggttt ttcagactcc     8760

atgcaccctg tggaaactgc ctttcttgag tagaggtacg ttcagcactt cataaaataa     8820

tcttggagcc tccagacaca cggatggagg agcatgattt catttgtttc tttgcaaaac     8880

tgctgtcccc aactgaaaaa cctgattatc ctttcaaata gggaattcgg ctttccacgt     8940

tggaaccaga acagttaacc ttcaaacccc caaggcttgc aagagatgaa tcagtttctc     9000

agacagccaa agccgtggct tataactcat ccaacccaga aaactggacc gctggtcacc     9060

ttccttcccc ctgcccccaa ctctgcagac agaggtttcc cgttgattat gccttgatta     9120

gagtcaggag agaagcaaac caggtatata ggattccatt atccttccct cctctgctcc     9180

caaccagggt cacgctgaga gggatctcgg tgaacatgtg aacaatcaag ccatgtttac     9240

catggacgtt tagttttctt ttctcaaaat caaaacagag tttagtaggc agcgtatttc     9300

atacatgccc cttgatcaat ggaatgatct gtcagaagcc attaaagccc ccattagctt     9360

gaatgcattc aaagctaaac tattggatca tttaagggct gcagtgattg tttttaatat     9420

accgtacatt gatttctccc tgtgagcagc aacataagtt tgaaactaac tgtgtatgac     9480

taaggctcca tttgctgtct ccaaccctct gtgagaagca tggtttcact tcgaccagaa     9540

atgtctgtgt atagttttca aagagatgca gaccctgttc gatttcccaa gatttagact     9600

gggtcgggtt gttatttctt ttttccctga gctttctccc atttctttgt gcccattaag     9660

tgagctgtgc gtgcagaatg ggagaggcat ccctgccaag gacttcaagt gaaaggcggt     9720

gggagaaatt gttctgaaag catgaagccc agctgaggcc aaaatcaaag tgaatttgac     9780

agccttgggc cagcaaaact ctgtacccag cagaaaacaa tagatgtgtg gctgtgtcag     9840

gggcatcctc actgggacat agcttgggga gctgaaggta ccttggaagg gccagatgag     9900

gaagctagcc aaggccacag gccttccttt gactgccata ttgccagctc ttcatagtat     9960

tgactcttca gtcttagcca acacacactt gttgattcct tccggaatgt cagactctgc    10020

tagcaacaca aggtccctgt cctcaaaatc ctattcttaa tcagcatttc taatttctgc    10080

cctttgctca ttttaataca gagcctgagg ataggagagc agcgtggtga aagaagcaat    10140

agttaccaca tttgcaaagg cacatacccc aaagagaagt ttttaatatg tcacacccat    10200

attttataga tggggcaatg gaagtccaga tgggagaagt tatttcaggt gaattataga    10260

aactggattt caagtttctg ataagtattg aatttgggaa ggctgtgaac attcttgagc    10320

ccccctccca agttcacctt caacatccta aagcaggttg aagaggaaga tggttccagg    10380

tcacttacaa gaacaggaac agcccctccc tccaaatttg agcccagaaa ggagaacctt    10440

tgttactcta gaaaacagtg tgtgtgctat tgttttctcc ataggtcaca aacatccaca    10500

agatattggt gattttacat attattagag ccactgaaat ttatgatgca ggatattaac    10560

gtcaaagagg ccaagatgca tcattcagaa cactggcagg tcaagcagaa accaccgtag    10620

taaaattgaa agctggagtc agcaaagtat agcccacagc caaatctggc ccatcccctg    10680

ttcttataaa gttttattgg aacgcagcca tgctcatcgg tttatgtatt atctatggct    10740

gtttccaact acagtggcag agctgaatag ttgcaaagga ccatagggct atcaaagccc    10800

caaatagtca ttgtctgacc cttcatagaa aaattttgct gaactgtagt ctagctccaa    10860

ggattgttgt atcacctgtg atcgtgccta ttaagcaatt aacgtcatgt ctagtactta    10920

gtaatgactc agcatgtatc aattacgatg ataaatatta tcatggcatc caaaccaaaa    10980

tactcatgcc aacatctctc tgtacagaaa catggaaaaa gagcgatgct attaaggagg    11040

aaaatggagc caggagcaaa acctaaggct atttctgaac taaagaggcc tgaataaggt    11100

agtgaaagga ccagggaaag ccttcccacg gggatggaga gccacctcct ccccggcttt    11160

ctggttcaga tgtcttgtct caacagacgg cagattcgca gggaagcagg ccgagcctga    11220

tcttttctcc gctagaactg ctcaacaggt gaagaatctt tttccagcac tcctgagccc    11280

ttcgggtcgc ggaacagtgc gaagattatt ccaatgcctc attcggagag gtgataatct    11340

ggtctgtggt ttctttttcg gtggggcatg gggtgggggt gagtgtcatg ctttctaagg    11400

cacagggctg actaaagggt gtcctattta taagtcagta aaacacagcg gcttcatact    11460

ctgtgcttat tacccagaag ccccggctct tagagtttct attaagatgt acctcataaa    11520

tatatacgcc tcctatgtac ccacaaaaat taaaaataaa aaaattgaaa tca           11573


<210> 2
<211> 505
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Arg Thr Pro Thr Ala Glu Glu Arg Glu Arg Glu Ala Lys Lys 
1               5                   10                  15      


Leu Arg Leu Leu Glu Glu Leu Glu Asp Thr Trp Leu Pro Tyr Leu Thr 
            20                  25                  30          


Pro Lys Asp Asp Glu Phe Tyr Gln Gln Trp Gln Leu Lys Tyr Pro Lys 
        35                  40                  45              


Leu Ile Leu Arg Glu Ala Ser Ser Val Ser Glu Glu Leu His Lys Glu 
    50                  55                  60                  


Val Gln Glu Ala Phe Leu Thr Leu His Lys His Gly Cys Leu Phe Arg 
65                  70                  75                  80  


Asp Leu Val Arg Ile Gln Gly Lys Asp Leu Leu Thr Pro Val Ser Arg 
                85                  90                  95      


Ile Leu Ile Gly Asn Pro Gly Cys Thr Tyr Lys Tyr Leu Asn Thr Arg 
            100                 105                 110         


Leu Phe Thr Val Pro Trp Pro Val Lys Gly Ser Asn Ile Lys His Thr 
        115                 120                 125             


Glu Ala Glu Ile Ala Ala Ala Cys Glu Thr Phe Leu Lys Leu Asn Asp 
    130                 135                 140                 


Tyr Leu Gln Ile Glu Thr Ile Gln Ala Leu Glu Glu Leu Ala Ala Lys 
145                 150                 155                 160 


Glu Lys Ala Asn Glu Asp Ala Val Pro Leu Cys Met Ser Ala Asp Phe 
                165                 170                 175     


Pro Arg Val Gly Met Gly Ser Ser Tyr Asn Gly Gln Asp Glu Val Asp 
            180                 185                 190         


Ile Lys Ser Arg Ala Ala Tyr Asn Val Thr Leu Leu Asn Phe Met Asp 
        195                 200                 205             


Pro Gln Lys Met Pro Tyr Leu Lys Glu Glu Pro Tyr Phe Gly Met Gly 
    210                 215                 220                 


Lys Met Ala Val Ser Trp His His Asp Glu Asn Leu Val Asp Arg Ser 
225                 230                 235                 240 


Ala Val Ala Val Tyr Ser Tyr Ser Cys Glu Gly Pro Glu Glu Glu Ser 
                245                 250                 255     


Glu Asp Asp Ser His Leu Glu Gly Arg Asp Pro Asp Ile Trp His Val 
            260                 265                 270         


Gly Phe Lys Ile Ser Trp Asp Ile Glu Thr Pro Gly Leu Ala Ile Pro 
        275                 280                 285             


Leu His Gln Gly Asp Cys Tyr Phe Met Leu Asp Asp Leu Asn Ala Thr 
    290                 295                 300                 


His Gln His Cys Val Leu Ala Gly Ser Gln Pro Arg Phe Ser Ser Thr 
305                 310                 315                 320 


His Arg Val Ala Glu Cys Ser Thr Gly Thr Leu Asp Tyr Ile Leu Gln 
                325                 330                 335     


Arg Cys Gln Leu Ala Leu Gln Asn Val Cys Asp Asp Val Asp Asn Asp 
            340                 345                 350         


Asp Val Ser Leu Lys Ser Phe Glu Pro Ala Val Leu Lys Gln Gly Glu 
        355                 360                 365             


Glu Ile His Asn Glu Val Glu Phe Glu Trp Leu Arg Gln Phe Trp Phe 
    370                 375                 380                 


Gln Gly Asn Arg Tyr Arg Lys Cys Thr Asp Trp Trp Cys Gln Pro Met 
385                 390                 395                 400 


Ala Gln Leu Glu Ala Leu Trp Lys Lys Met Glu Gly Val Thr Asn Ala 
                405                 410                 415     


Val Leu His Glu Val Lys Arg Glu Gly Leu Pro Val Glu Gln Arg Asn 
            420                 425                 430         


Glu Ile Leu Thr Ala Ile Leu Ala Ser Leu Thr Ala Arg Gln Asn Leu 
        435                 440                 445             


Arg Arg Glu Trp His Ala Arg Cys Gln Ser Arg Ile Ala Arg Thr Leu 
    450                 455                 460                 


Pro Ala Asp Gln Lys Pro Glu Cys Arg Pro Tyr Trp Glu Lys Asp Asp 
465                 470                 475                 480 


Ala Ser Met Pro Leu Pro Phe Asp Leu Thr Asp Ile Val Ser Glu Leu 
                485                 490                 495     


Arg Gly Gln Leu Leu Glu Ala Lys Pro 
            500                 505 


