                               SEQUENCE LISTING

<110> NANTKWEST, INC.
 
<120> USE OF CD33CAR MODIFIED HIGH AFFINITY NK CELLS (T-HANK) TO REDUCE
      MYELOID-DERIVED SUPPRESSOR CELLS SUPPRESSOR ACTIVITY (OR REDUCE 
      NEGATIVE IMPACT ON NK CELL ACTIVITY)

<130> 104066-1128807-6110WO

<140>
<141>

<150> 62/641,915
<151> 2018-03-12

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
1               5                   10                  15      


Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
            20                  25                  30          


Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40      


<210> 2
<211> 65
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe 
1               5                   10                  15      


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            20                  25                  30          


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        35                  40                  45              


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    50                  55                  60                  


Cys 
65  


<210> 3
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            20                  25              


<210> 4
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210> 5
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 6
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210> 7
<211> 153
<212> PRT
<213> Homo sapiens

<400> 7
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 8
<211> 160
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Ser Glu Lys Asp Glu Leu 
145                 150                 155                 160 


<210> 9
<211> 236
<212> PRT
<213> Homo sapiens

<400> 9
Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp 
    210                 215                 220                 


His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
225                 230                 235     


<210> 10
<211> 236
<212> PRT
<213> Homo sapiens

<400> 10
Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp 
    210                 215                 220                 


His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
225                 230                 235     


<210> 11
<211> 254
<212> PRT
<213> Homo sapiens

<400> 11
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210> 12
<211> 254
<212> PRT
<213> Homo sapiens

<400> 12
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210> 13
<211> 765
<212> DNA
<213> Homo sapiens

<400> 13
atgtggcagc tgctcctccc aactgctctg ctacttctag tttcagctgg catgcggact       60

gaagatctcc caaaggctgt ggtgttcctg gagcctcaat ggtacagggt gctcgagaag      120

gacagtgtga ctctgaagtg ccagggagcc tactcccctg aggacaattc cacacagtgg      180

tttcacaatg agagcctcat ctcaagccag gcctcgagct acttcattga cgctgccaca      240

gtcgacgaca gtggagagta caggtgccag acaaacctct ccaccctcag tgacccggtg      300

cagctagaag tccatatcgg ctggctgttg ctccaggccc ctcggtgggt gttcaaggag      360

gaagacccta ttcacctgag gtgtcacagc tggaagaaca ctgctctgca taaggtcaca      420

tatttacaga atggcaaagg caggaagtat tttcatcata attctgactt ctacattcca      480

aaagccacac tcaaagacag cggctcctac ttctgcaggg ggctttttgg gagtaaaaat      540

gtgtcttcag agactgtgaa catcaccatc actcaaggtt tggcagtgtc aaccatctca      600

tcattctttc cacctgggta ccaagtctct ttctgcttgg tgatggtact cctttttgca      660

gtggacacag gactatattt ctctgtgaag acaaacattc gaagctcaac aagagactgg      720

aaggaccata aatttaaatg gagaaaggac cctcaagaca aatga                      765


<210> 14
<211> 795
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 14
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggccg acattcaaat gactcagtcc ccttccagct tgtcagcctc agtaggggac      120

cgggtcacga tcacctgtcg agcgtctgag tcagtggata actacgggat ttctttcatg      180

aactggttcc agcagaagcc cggcaaagct cctaagctcc ttatatatgc agcctcaaat      240

caggggagcg gtgttcctag tcgcttcagt ggaagcggta gcggtacgga ctttacgttg      300

acgataagta gccttcagcc agatgacttt gccacttatt attgtcagca gtctaaggaa      360

gttccttgga cgtttggcca aggaacgaag gtcgaaatca aagggggagg gggctcagga      420

gggggcggca gtggtggtgg aggctctcaa gtccaactcg tacagtctgg cgcggaggtt      480

aaaaagccgg gaagctccgt gaaagtatcc tgtaaggcaa gcggatacac ctttaccgat      540

tataacatgc actgggttag gcaggcgccc ggccaaggtc tggaatggat cggttatatt      600

tatccataca acggtggtac cggctataat cagaagttta agagtaaggc tactattaca      660

gcggatgagt caaccaatac tgcatacatg gagctctcct cactcaggag cgaagatacc      720

gcagtgtatt actgtgcccg agggagacca gccatggact actggggtca gggtaccctt      780

gtgacagtat ctagc                                                       795


<210> 15
<211> 265
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn 
65                  70                  75                  80  


Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser 
    210                 215                 220                 


Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265 


<210> 16
<211> 401
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn 
65                  70                  75                  80  


Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser 
    210                 215                 220                 


Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Leu Ser Asn Ser 
            260                 265                 270         


Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro 
        275                 280                 285             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    290                 295                 300                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
305                 310                 315                 320 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Phe Trp Val Leu 
                325                 330                 335     


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            340                 345                 350         


Ala Phe Ile Ile Phe Trp Val Arg Leu Lys Ile Gln Val Arg Lys Ala 
        355                 360                 365             


Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser 
    370                 375                 380                 


Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro 
385                 390                 395                 400 


Gln 
    


<210> 17
<211> 1203
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggccg acattcaaat gactcagtcc ccttccagct tgtcagcctc agtaggggac      120

cgggtcacga tcacctgtcg agcgtctgag tcagtggata actacgggat ttctttcatg      180

aactggttcc agcagaagcc cggcaaagct cctaagctcc ttatatatgc agcctcaaat      240

caggggagcg gtgttcctag tcgcttcagt ggaagcggta gcggtacgga ctttacgttg      300

acgataagta gccttcagcc agatgacttt gccacttatt attgtcagca gtctaaggaa      360

gttccttgga cgtttggcca aggaacgaag gtcgaaatca aagggggagg gggctcagga      420

gggggcggca gtggtggtgg aggctctcaa gtccaactcg tacagtctgg cgcggaggtt      480

aaaaagccgg gaagctccgt gaaagtatcc tgtaaggcaa gcggatacac ctttaccgat      540

tataacatgc actgggttag gcaggcgccc ggccaaggtc tggaatggat cggttatatt      600

tatccataca acggtggtac cggctataat cagaagttta agagtaaggc tactattaca      660

gcggatgagt caaccaatac tgcatacatg gagctctcct cactcaggag cgaagatacc      720

gcagtgtatt actgtgcccg agggagacca gccatggact actggggtca gggtaccctt      780

gtgacagtat ctagcgcggc cgcgctgagc aacagcatca tgtacttcag ccacttcgtg      840

cctgtgttcc tgcctgccaa gcctacaaca acaccagccc ctagacctcc aacccctgcc      900

cctacaattg cctctcagcc tctgtctctg aggcccgaag cttgtagacc tgctgctggc      960

ggagctgtgc acaccagagg actggatttc gcctgctttt gggtgctggt ggtcgtgggc     1020

ggagtgctgg cttgttattc tctgctggtc accgtggcct tcatcatctt ttgggtccga     1080

ctgaagatcc aggtccgaaa ggccgccatc accagctacg agaagtctga tggcgtgtac     1140

accggcctga gcaccagaaa ccaggaaacc tacgagacac tgaagcacga gaagcccccc     1200

cag                                                                   1203


<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Ala Ser Asn Gln Gly Ser 
1               5       


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Asp Tyr Asn Met His 
1               5   


<210> 22
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Gly Arg Pro Ala Met Asp Tyr 
1               5           


<210> 24
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210> 25
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 26
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      'KDEL' motif peptide"

<400> 26
Lys Asp Glu Leu 
1               


<210> 27
<211> 3126
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 27
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattcggcc       60

cagccggccg acattcaaat gactcagtcc ccttccagct tgtcagcctc agtaggggac      120

cgggtcacga tcacctgtcg agcgtctgag tcagtggata actacgggat ttctttcatg      180

aactggttcc agcagaagcc cggcaaagct cctaagctcc ttatatatgc agcctcaaat      240

caggggagcg gtgttcctag tcgcttcagt ggaagcggta gcggtacgga ctttacgttg      300

acgataagta gccttcagcc agatgacttt gccacttatt attgtcagca gtctaaggaa      360

gttccttgga cgtttggcca aggaacgaag gtcgaaatca aagggggagg gggctcagga      420

gggggcggca gtggtggtgg aggctctcaa gtccaactcg tacagtctgg cgcggaggtt      480

aaaaagccgg gaagctccgt gaaagtatcc tgtaaggcaa gcggatacac ctttaccgat      540

tataacatgc actgggttag gcaggcgccc ggccaaggtc tggaatggat cggttatatt      600

tatccataca acggtggtac cggctataat cagaagttta agagtaaggc tactattaca      660

gcggatgagt caaccaatac tgcatacatg gagctctcct cactcaggag cgaagatacc      720

gcagtgtatt actgtgcccg agggagacca gccatggact actggggtca gggtaccctt      780

gtgacagtat ctagcgcggc cgcgctgagc aacagcatca tgtacttcag ccacttcgtg      840

cctgtgttcc tgcctgccaa gcctacaaca acaccagccc ctagacctcc aacccctgcc      900

cctacaattg cctctcagcc tctgtctctg aggcccgaag cttgtagacc tgctgctggc      960

ggagctgtgc acaccagagg actggatttc gcctgctttt gggtgctggt ggtcgtgggc     1020

ggagtgctgg cttgttattc tctgctggtc accgtggcct tcatcatctt ttgggtccga     1080

ctgaagatcc aggtccgaaa ggccgccatc accagctacg agaagtctga tggcgtgtac     1140

accggcctga gcaccagaaa ccaggaaacc tacgagacac tgaagcacga gaagcccccc     1200

cagggatccg gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac     1260

cctggaccta tgtggcagct gctgctgcct acagctctcc tgctgctggt gtccgccggc     1320

atgagaaccg aggatctgcc taaggccgtg gtgttcctgg aaccccagtg gtacagagtg     1380

ctggaaaagg acagcgtgac cctgaagtgc cagggcgcct acagccccga ggacaatagc     1440

acccagtggt tccacaacga gagcctgatc agcagccagg ccagcagcta cttcatcgac     1500

gccgccaccg tggacgacag cggcgagtat agatgccaga ccaacctgag caccctgagc     1560

gaccccgtgc agctggaagt gcacatcgga tggctgctgc tgcaggcccc cagatgggtg     1620

ttcaaagaag aggaccccat ccacctgaga tgccactctt ggaagaacac cgccctgcac     1680

aaagtgacct acctgcagaa cggcaagggc agaaagtact tccaccacaa cagcgacttc     1740

tacatcccca aggccaccct gaaggactcc ggctcctact tctgcagagg cctcgtgggc     1800

agcaagaacg tgtccagcga gacagtgaac atcaccatca cccagggcct ggccgtgtct     1860

accatcagca gctttttccc acccggctac caggtgtcct tctgcctcgt gatggtgctg     1920

ctgttcgccg tggacaccgg cctgtacttc agcgtgaaaa caaacatcag aagcagcacc     1980

cgggactgga aggaccacaa gttcaagtgg cggaaggacc cccaggacaa gtgaaattcc     2040

gcccctctcc cccccccccc tctccctccc ccccccctaa cgttactggc cgaagccgct     2100

tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg     2160

gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt     2220

cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg     2280

aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac     2340

ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg     2400

cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct     2460

caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg     2520

atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag     2580

gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgataaccg ccaccatgta     2640

ccggatgcag ctgctgagct gtatcgccct gtctctggcc ctcgtgacca acagcgcccc     2700

taccagcagc agcaccaaga aaacccagct gcagctggaa catctgctgc tggacctgca     2760

gatgatcctg aacggcatca acaactacaa gaaccccaag ctgacccgga tgctgacctt     2820

caagttctac atgcccaaga aggccaccga actgaaacat ctgcagtgcc tggaagagga     2880

actgaagccc ctggaagaag tgctgaacct ggcccagagc aagaacttcc acctgaggcc     2940

cagggacctg atcagcaaca tcaacgtgat cgtgctggaa ctgaaaggca gcgagacaac     3000

cttcatgtgc gagtacgccg acgagacagc taccatcgtg gaatttctga accggtggat     3060

caccttctgc cagagcatca tcagcaccct gaccggctcc gagaaggacg agctgtgagc     3120

ggccgc                                                                3126


<210> 28
<211> 677
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn 
65                  70                  75                  80  


Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser 
    210                 215                 220                 


Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Leu Ser Asn Ser 
            260                 265                 270         


Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro 
        275                 280                 285             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    290                 295                 300                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
305                 310                 315                 320 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Phe Trp Val Leu 
                325                 330                 335     


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            340                 345                 350         


Ala Phe Ile Ile Phe Trp Val Arg Leu Lys Ile Gln Val Arg Lys Ala 
        355                 360                 365             


Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser 
    370                 375                 380                 


Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro 
385                 390                 395                 400 


Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                405                 410                 415     


Val Glu Glu Asn Pro Gly Pro Met Trp Gln Leu Leu Leu Pro Thr Ala 
            420                 425                 430         


Leu Leu Leu Leu Val Ser Ala Gly Met Arg Thr Glu Asp Leu Pro Lys 
        435                 440                 445             


Ala Val Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp 
    450                 455                 460                 


Ser Val Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser 
465                 470                 475                 480 


Thr Gln Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser 
                485                 490                 495     


Tyr Phe Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys 
            500                 505                 510         


Gln Thr Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His 
        515                 520                 525             


Ile Gly Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu 
    530                 535                 540                 


Asp Pro Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His 
545                 550                 555                 560 


Lys Val Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His 
                565                 570                 575     


Asn Ser Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser 
            580                 585                 590         


Tyr Phe Cys Arg Gly Leu Val Gly Ser Lys Asn Val Ser Ser Glu Thr 
        595                 600                 605             


Val Asn Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser 
    610                 615                 620                 


Phe Phe Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu 
625                 630                 635                 640 


Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile 
                645                 650                 655     


Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys 
            660                 665                 670         


Asp Pro Gln Asp Lys 
        675         


