                         SEQUENCE LISTING

<110>  Phanes Therapeutics, Inc.
 
<120>  Anti-Folate Receptor 1 Antibodies and Uses Thereof

<130>  689204-11WO

<150>  62/642,213
<151>  2018-03-13

<160>  135   

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 Heavy Chain Variable Region

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Asn Thr Ile Tyr Tyr Ala Asp Ile Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ala Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Glu Trp Asp Val Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  2
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 Light Chain Variable Region

<400>  2

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Ile Ser Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Asn Gly Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ile Tyr Ser Trp Pro Gln 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
            100                 105             


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 Heavy Chain Variable Region

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Glu Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Gln Gly Ser Ser Gly Tyr Val Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  4
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 Light Chain Variable Region

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Phe Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Thr Asn Phe 
            20                  25                  30          


Ile Gly Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Tyr Thr Ser Ile Leu Glu Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Tyr Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 Heavy Chain Variable Region

<400>  5

Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Asn Tyr Gly Thr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Val Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ile Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ala Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ile Lys Gly Tyr Gly Asn Pro Ala Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  6
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 Light Chain Variable Region

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Glu Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Ile Leu Glu Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Tyr Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 Heavy Chain Variable Region

<400>  7

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Gly Asp Thr Tyr His Leu Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ser His Tyr Gly Ser Ser Tyr Tyr Phe Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 Light Chain Variable Region

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Ile Val Thr Ile Ile Cys Arg Val Ser Glu Asn Ile Asp Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Arg Tyr Tyr Cys Gln His Tyr Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 Heavy Chain Variable Region

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Tyr Thr His Tyr Asn Gly Met Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg His Gly Asp Phe Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 Light Chain Variable Region

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Asp Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Thr Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Arg Tyr Tyr Cys Gln His His Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 Heavy Chain Variable Region

<400>  11

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Gly Met His Trp Ile Arg Gln Ala Pro Glu Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Met Ser Tyr Thr Pro Gly Thr Phe His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Asp Arg Phe Phe Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val His Val Gly Thr Val Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 Light Chain Variable Region

<400>  12

Asp Val Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Phe Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Asn Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Ile Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Ala 
                85                  90                  95      


Leu Thr Phe Gly Thr Gly Thr Lys Val Glu Leu Lys 
            100                 105             


<210>  13
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 Heavy Chain Variable Region

<400>  13

Glu Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Pro Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Ile Gly Asn Lys Phe His Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Lys Leu Gly Arg Gly Tyr Tyr Val Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 Light Chain Variable Region

<400>  14

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Arg Ala Ser Gln Asp Ile Thr Asn His 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Phe Gln Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Asp Ser Gln His Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 Heavy Chain Variable Region

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Tyr 
            20                  25                  30          


Tyr Leu Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Arg Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Val Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Gly Arg Leu Arg Gly Phe Tyr Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 Light Chain Variable Region

<400>  16

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Gly Glu Asn Val Gly Ser Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Tyr Cys Gly Gln Thr Tyr Arg Phe Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 HCDR1

<400>  17

Gly Phe Thr Phe Ser Asp Tyr Gly 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 HCDR2

<400>  18

Ile Ser Ser Gly Ser Asn Thr Ile 
1               5               


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 HCDR3

<400>  19

Ala Arg Leu Ala Glu Trp Asp Val Ala Tyr 
1               5                   10  


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 HCDR1

<400>  20

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 HCDR2

<400>  21

Ile Ser Ser Gly Gly Ser Tyr Thr 
1               5               


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 HCDR3

<400>  22

Ser Thr Gln Gly Ser Ser Gly Tyr Val Gly Tyr 
1               5                   10      


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 HCDR1

<400>  23

Gly Tyr Ser Phe Thr Asp Tyr Asn 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 HCDR2

<400>  24

Ile Asp Pro Asn Tyr Gly Thr Thr 
1               5               


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 HCDR3

<400>  25

Ala Ile Lys Gly Tyr Gly Asn Pro Ala Ala Tyr 
1               5                   10      


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 HCDR1

<400>  26

Gly Phe Thr Leu Ser Thr Tyr Ala 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 HCDR2

<400>  27

Ile Ser Gly Gly Gly Gly Asp Thr 
1               5               


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 HCDR3

<400>  28

Ala Arg Gln Ser His Tyr Gly Ser Ser Tyr Tyr Phe Asp Asn 
1               5                   10                  


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 HCDR1

<400>  29

Gly Tyr Ala Phe Ser Ser Ser Trp 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 HCDR2

<400>  30

Ile Tyr Pro Gly Asp Gly Tyr Thr 
1               5               


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 HCDR3

<400>  31

Thr Arg His Gly Asp Phe Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 HCDR1

<400>  32

Gly Phe Thr Phe Ser Asp Phe Gly 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 HCDR2

<400>  33

Met Ser Tyr Thr Pro Gly Thr Phe 
1               5               


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 HCDR3

<400>  34

Ala Arg Val His Val Gly Thr Val Asp Tyr 
1               5                   10  


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 HCDR1

<400>  35

Gly Phe Thr Phe Ser Asp Tyr Trp 
1               5               


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 HCDR2

<400>  36

Ile Gly Asn Lys Phe His Asn Tyr Glu Thr 
1               5                   10  


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 HCDR3

<400>  37

Thr Lys Leu Gly Arg Gly Tyr Tyr Val Met Asp Tyr 
1               5                   10          


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 HCDR1

<400>  38

Gly Tyr Thr Phe Ala Ser Tyr Tyr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 HCDR2

<400>  39

Ile Asn Pro Arg Ser Gly Gly Thr 
1               5               


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 HCDR3

<400>  40

Ser Arg Ser Gly Arg Leu Arg Gly Phe Tyr Thr Met Asp Tyr 
1               5                   10                  


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 LCDR1

<400>  41

Gln Asn Ile Asn Asn Asn 
1               5       


<210>  42
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 LCDR2

<400>  42

Phe Ala Ser 
1           


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 LCDR3

<400>  43

Gln Gln Ile Tyr Ser Trp Pro Gln Leu Thr 
1               5                   10  


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 LCDR1

<400>  44

Gln Asp Ile Thr Asn Phe 
1               5       


<210>  45
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 LCDR2

<400>  45

Tyr Thr Ser 
1           


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 LCDR3

<400>  46

Leu Gln Tyr Tyr Asn Leu Trp Thr 
1               5               


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 LCDR1

<400>  47

Gln Asp Ile Asn Lys Tyr 
1               5       


<210>  48
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 LCDR2

<400>  48

Tyr Thr Ser 
1           


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 LCDR3

<400>  49

Leu Gln Tyr Tyr Asn Leu Trp Thr 
1               5               


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 LCDR1

<400>  50

Glu Asn Ile Asp Ser Tyr 
1               5       


<210>  51
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 LCDR2

<400>  51

Ala Ala Thr 
1           


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 LCDR3

<400>  52

Gln His Tyr Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 LCDR1

<400>  53

Glu Asn Ile Asp Ser Tyr 
1               5       


<210>  54
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 LCDR2

<400>  54

Ala Ala Thr 
1           


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 LCDR3

<400>  55

Gln His His Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 LCDR1

<400>  56

Gln Asn Ile Asn Asn Asn 
1               5       


<210>  57
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 LCDR2

<400>  57

Tyr Ala Ser 
1           


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 LCDR3

<400>  58

Gln Gln Ser Asn Ser Trp Pro Ala Leu Thr 
1               5                   10  


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 LCDR1

<400>  59

Gln Asp Ile Thr Asn His 
1               5       


<210>  60
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 LCDR2

<400>  60

Tyr Thr Ser 
1           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 LCDR3

<400>  61

Gln Gln Asp Ser Gln His Pro Trp Thr 
1               5                   


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 LCDR1

<400>  62

Glu Asn Val Gly Ser Tyr 
1               5       


<210>  63
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 LCDR2

<400>  63

Gly Ala Ser 
1           


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 LCDR3

<400>  64

Gly Gln Thr Tyr Arg Phe Leu Thr 
1               5               


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 HCDR1

<400>  65

Gly Phe Thr Phe Ser Asp Tyr Gly Met His 
1               5                   10  


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 HCDR2

<400>  66

Phe Ile Ser Ser Gly Ser Asn Thr Ile Tyr Tyr Ala Asp Ile Val Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 HCDR3

<400>  67

Ala Arg Leu Ala Glu Trp Asp Val Ala Tyr 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 HCDR1

<400>  68

Gly Phe Thr Phe Ser Asn Tyr Gly Met Ser 
1               5                   10  


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 HCDR2

<400>  69

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 HCDR3

<400>  70

Ser Thr Gln Gly Ser Ser Gly Tyr Val Gly Tyr 
1               5                   10      


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 HCDR1

<400>  71

Gly Tyr Ser Phe Thr Asp Tyr Asn Met Asn 
1               5                   10  


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 HCDR2

<400>  72

Val Ile Asp Pro Asn Tyr Gly Thr Thr Asn Tyr Asn Gln Lys Phe Val 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 HCDR3

<400>  73

Ala Ile Lys Gly Tyr Gly Asn Pro Ala Ala Tyr 
1               5                   10      


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 HCDR1

<400>  74

Gly Phe Thr Leu Ser Thr Tyr Ala Met Ser 
1               5                   10  


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 HCDR2

<400>  75

Thr Ile Ser Gly Gly Gly Gly Asp Thr Tyr His Leu Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 HCDR3

<400>  76

Ala Arg Gln Ser His Tyr Gly Ser Ser Tyr Tyr Phe Asp Asn 
1               5                   10                  


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 HCDR1

<400>  77

Gly Tyr Ala Phe Ser Ser Ser Trp Met Asn 
1               5                   10  


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 HCDR2

<400>  78

Arg Ile Tyr Pro Gly Asp Gly Tyr Thr His Tyr Asn Gly Met Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 HCDR3

<400>  79

Thr Arg His Gly Asp Phe Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 HCDR1

<400>  80

Gly Phe Thr Phe Ser Asp Phe Gly Met His 
1               5                   10  


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 HCDR2

<400>  81

Tyr Met Ser Tyr Thr Pro Gly Thr Phe His Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Asp 
    


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 HCDR3

<400>  82

Ala Arg Val His Val Gly Thr Val Asp Tyr 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 HCDR1

<400>  83

Gly Phe Thr Phe Ser Asp Tyr Trp Met Asn 
1               5                   10  


<210>  84
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 HCDR2

<400>  84

Gln Ile Gly Asn Lys Phe His Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 HCDR3

<400>  85

Thr Lys Leu Gly Arg Gly Tyr Tyr Val Met Asp Tyr 
1               5                   10          


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 HCDR1

<400>  86

Gly Tyr Thr Phe Ala Ser Tyr Tyr Leu Tyr 
1               5                   10  


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 HCDR2

<400>  87

Glu Ile Asn Pro Arg Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  88
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 HCDR3

<400>  88

Ser Arg Ser Gly Arg Leu Arg Gly Phe Tyr Thr Met Asp Tyr 
1               5                   10                  


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 LCDR1

<400>  89

Arg Ala Ser Gln Asn Ile Asn Asn Asn Leu His 
1               5                   10      


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 LCDR2

<400>  90

Phe Ala Ser Gln Ser Ile Ser 
1               5           


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 LCDR3

<400>  91

Gln Gln Ile Tyr Ser Trp Pro Gln Leu Thr 
1               5                   10  


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 LCDR1

<400>  92

Lys Ala Ser Gln Asp Ile Thr Asn Phe Ile Gly 
1               5                   10      


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 LCDR2

<400>  93

Tyr Thr Ser Ile Leu Glu Ser 
1               5           


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 LCDR3

<400>  94

Leu Gln Tyr Tyr Asn Leu Trp Thr 
1               5               


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 LCDR1

<400>  95

Lys Ala Ser Gln Asp Ile Asn Lys Tyr Leu Ala 
1               5                   10      


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 LCDR2

<400>  96

Tyr Thr Ser Ile Leu Glu Ser 
1               5           


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7 LCDR3

<400>  97

Leu Gln Tyr Tyr Asn Leu Trp Thr 
1               5               


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 LCDR1

<400>  98

Arg Val Ser Glu Asn Ile Asp Ser Tyr Leu Ala 
1               5                   10      


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 LCDR2

<400>  99

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 LCDR3

<400>  100

Gln His Tyr Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 LCDR1

<400>  101

Arg Ala Ser Glu Asn Ile Asp Ser Tyr Leu Ala 
1               5                   10      


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 LCDR2

<400>  102

Ala Ala Thr Asn Leu Ala Val 
1               5           


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10 LCDR3

<400>  103

Gln His His Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 LCDR1

<400>  104

Arg Ala Ser Gln Asn Ile Asn Asn Asn Leu His 
1               5                   10      


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 LCDR2

<400>  105

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17 LCDR3

<400>  106

Gln Gln Ser Asn Ser Trp Pro Ala Leu Thr 
1               5                   10  


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 LCDR1

<400>  107

Arg Ala Ser Gln Asp Ile Thr Asn His Leu Asn 
1               5                   10      


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 LCDR2

<400>  108

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F19 LCDR3

<400>  109

Gln Gln Asp Ser Gln His Pro Trp Thr 
1               5                   


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 LCDR1

<400>  110

Lys Ala Gly Glu Asn Val Gly Ser Tyr Val Ser 
1               5                   10      


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 LCDR2

<400>  111

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20 LCDR3

<400>  112

Gly Gln Thr Tyr Arg Phe Leu Thr 
1               5               


<210>  113
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5-H1 Heavy Chain Variable Region

<400>  113

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Gln Gly Ser Ser Gly Tyr Val Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  114
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5-H2 Heavy Chain Variable Region

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Gln Gly Ser Ser Gly Tyr Val Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  115
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5-H3 Heavy Chain Variable Region

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Gln Gly Ser Ser Gly Tyr Val Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  116
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5-H4 Heavy Chain Variable Region

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Gln Gly Ser Ser Gly Tyr Val Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  117
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5-L1 Light Chain Variable Region

<400>  117

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Thr Asn Phe 
            20                  25                  30          


Ile Gly Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Tyr Thr Ser Ile Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Tyr Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  118
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5-L2 Light Chain Variable Region

<400>  118

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Thr Asn Phe 
            20                  25                  30          


Ile Gly Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Tyr Thr Ser Ile Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Tyr Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  119
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10-H1 Heavy Chain Variable Region

<400>  119

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Tyr Thr His Tyr Asn Gly Met Phe 
    50                  55                  60                  


Lys Gly Arg Ala Ser Leu Thr Ala Asp Lys Ser Thr Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Phe Cys 
                85                  90                  95      


Thr Arg His Gly Asp Phe Pro Tyr Trp Tyr Phe Asp Val Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Pro 
        115                 120 


<210>  120
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10-H2 Heavy Chain Variable Region

<400>  120

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Tyr Thr His Tyr Asn Gly Met Phe 
    50                  55                  60                  


Lys Gly Arg Ala Ser Leu Thr Ala Asp Lys Ser Thr Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Phe Cys 
                85                  90                  95      


Thr Arg His Gly Asp Phe Pro Tyr Trp Tyr Phe Asp Val Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10-L1 Light Chain Variable Region

<400>  121

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Asp Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10-L2 Light Chain Variable Region

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Asp Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  123
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10-L3 Light Chain Variable Region

<400>  123

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Asp Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  124
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17-H1 Heavy Chain Variable Region

<400>  124

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Gly Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Met Ser Tyr Thr Pro Gly Thr Phe His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val His Val Gly Thr Val Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  125
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17-H2 Heavy Chain Variable Region

<400>  125

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Gly Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Met Ser Tyr Thr Pro Gly Thr Phe His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val His Val Gly Thr Val Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  126
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17-L1 Light Chain Variable Region

<400>  126

Glu Val Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Ala 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  127
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F17-L2 Light Chain Variable Region

<400>  127

Glu Val Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asn Asn 
            20                  25                  30          


Leu His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Ala 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  128
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20-H1 Heavy Chain Variable Region

<400>  128

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Tyr 
            20                  25                  30          


Tyr Leu Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Arg Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Val Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Gly Arg Leu Arg Gly Phe Tyr Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  129
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20-H2 Heavy Chain Variable Region

<400>  129

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Tyr 
            20                  25                  30          


Tyr Leu Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Arg Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Val Thr Val Asp Ala Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Gly Arg Leu Arg Gly Phe Tyr Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  130
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20-H3 Heavy Chain Variable Region

<400>  130

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Tyr 
            20                  25                  30          


Tyr Leu Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Arg Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Val Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Gly Arg Leu Arg Gly Phe Tyr Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  131
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20-L1 Light Chain Variable Region

<400>  131

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Gly Glu Asn Val Gly Ser Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gly Gln Thr Tyr Arg Phe Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  132
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20-L2 Light Chain Variable Region

<400>  132

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Gly Glu Asn Val Gly Ser Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gly Gln Thr Tyr Arg Phe Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  133
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20-L3 Light Chain Variable Region

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gly Glu Asn Val Gly Ser Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Thr Tyr Arg Phe Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105     


<210>  134
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F20-L4 Light Chain Variable Region

<400>  134

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gly Glu Asn Val Gly Ser Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Thr Tyr Arg Phe Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105     


<210>  135
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


