                         SEQUENCE LISTING

<110>  Biond Biologics Ltd.
 
<120>  METHODS AND COMPOSITIONS FOR DECREASING SOLUBLE IMMUNE RECEPTOR

<130>  BDB-P-003-PCT

<150>  62/643334
<151>  2018-03-15

<150>  62/643355
<151>  2018-03-15

<150>  62/774254
<151>  2018-12-02

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  2
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
    130                 135                 140                 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
145                 150                 155                 160 


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
                165                 170                 175     


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
            180                 185                 190         


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        195                 200         


<210>  3
<211>  663
<212>  DNA
<213>  Homo sapiens

<400>  3
atgctcaggc tgctcttggc tctcaactta ttcccttcaa ttcaagtaac aggaaacaag       60

attttggtga agcagtcgcc catgcttgta gcgtacgaca atgcggtcaa ccttagctgc      120

aagtattcct acaatctctt ctcaagggag ttccgggcat cccttcacaa aggactggat      180

agtgctgtgg aagtctgtgt tgtatatggg aattactccc agcagcttca ggtttactca      240

aaaacggggt tcaactgtga tgggaaattg ggcaatgaat cagtgacatt ctacctccag      300

aatttgtatg ttaaccaaac agatatttac ttctgcaaaa ttgaagttat gtatcctcct      360

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt      420

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      480

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtgagg      540

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg      600

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc      660

tga                                                                    663


<210>  4
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  5
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Glu Glu 
    130                 135                 


<210>  6
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  6

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Glu Glu 
        115                 120     


<210>  7
<211>  538
<212>  DNA
<213>  Homo sapiens

<400>  7
atgctcaggc tgctcttggc tctcaactta ttcccttcaa ttcaagtaac aggaaacaag       60

attttggtga agcagtcgcc catgcttgta gcgtacgaca atgcggtcaa ccttagctgc      120

aagtattcct acaatctctt ctcaagggag ttccgggcat cccttcacaa aggactggat      180

agtgctgtgg aagtctgtgt tgtatatggg aattactccc agcagcttca ggtttactca      240

aaaacggggt tcaactgtga tgggaaattg ggcaatgaat cagtgacatt ctacctccag      300

aatttgtatg ttaaccaaac agatatttac ttctgcaaaa ttgaagttat gtatcctcct      360

ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg tgaggagtaa      420

gaggagcagg ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac      480

ccgcaagcat taccagccct atgccccacc acgcgacttc gcagcctatc gctcctga        538


<210>  8
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
1               5                   10                  15      


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
            20                  25                  30          


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
        35                  40                  45              


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
    50                  55                  60                  


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
65                  70                  75                  80  


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
                85                  90                  95      


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
            100                 105                 110 


<210>  9
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10                  15      


<210>  10
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  10

His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
1               5                   10                  15      


Ser Lys Pro 
            


<210>  11
<211>  8
<212>  DNA
<213>  Homo sapiens

<400>  11
aaaggtga                                                                 8


<210>  12
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Gly Tyr Thr Leu Thr Asn Tyr 
1               5           


<210>  13
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Asn Thr Tyr Thr Gly Lys 
1               5       


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Gly Asp Ala Asn Gln Gln Phe Ala Tyr 
1               5                   


<210>  15
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Leu Gln Tyr Asp Glu Phe Pro Pro Thr 
1               5                   


<210>  18
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  19
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Tyr Pro Gly Asp Gly Asp 
1               5       


<210>  20
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Asn Tyr Arg Tyr Ser Ser Phe Gly Tyr 
1               5                   


<210>  21
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  22
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Gln Ser Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  24
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  25
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  25

Asn Pro Asn Tyr Asp Ser 
1               5       


<210>  26
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

Ser Ser Pro Tyr Tyr Asp Ser Asn His Phe Asp Tyr 
1               5                   10          


<210>  27
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  27

Ser Ala Arg Ser Ser Ile Asn Tyr Met His 
1               5                   10  


<210>  28
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  28

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  29

His Gln Arg Asn Ser Tyr Pro Phe Thr 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  30

Gly Phe Thr Phe Ser Ser Tyr Tyr Met Ser 
1               5                   10  


<210>  31
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  31

Thr Ile Ser Asp Gly Gly Asp Asn Thr Tyr Tyr Ala Gly Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  32

Ile His Trp Pro Tyr Tyr Phe Asp Ser 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  33

Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  34
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  34

Ala Thr Ser Asp Leu Ala Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  35

Gln Gln Trp Ser Ser His Pro Pro Thr 
1               5                   


<210>  36
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  36

Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
1               5                   10                  15  


<210>  37
<211>  134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  37

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro 
    130                 


<210>  38
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  38
atgctgaggc tgctcttggc tctcaac                                           27


<210>  39
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  39
tcaggagcga taggctgcga agtcgcg                                           27


<210>  40
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  40

Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10                  15      


Lys 
    


<210>  41
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  41

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Ala Asn Gln Gln Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  42
<211>  442
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  42

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Ala Asn Gln Gln Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
    210                 215                 220                 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            260                 265                 270         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
305                 310                 315                 320 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
            340                 345                 350         


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
        355                 360                 365             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                405                 410                 415     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440         


<210>  43
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  43

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Asp Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  44
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  44

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Asp Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  45
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  45

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Ile Lys Lys Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Tyr Arg Tyr Ser Ser Phe Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  46
<211>  454
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  46

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Ile Lys Lys Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Tyr Arg Tyr Ser Ser Phe Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln 
                165                 170                 175     


Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile 
    210                 215                 220                 


Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn 
225                 230                 235                 240 


Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp 
                245                 250                 255     


Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
        275                 280                 285             


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
    290                 295                 300                 


Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His Gln Asp Trp 
305                 310                 315                 320 


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala 
            340                 345                 350         


Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys 
        355                 360                 365             


Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile 
    370                 375                 380                 


Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp 
385                 390                 395                 400 


Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys 
                405                 410                 415     


Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys 
            420                 425                 430         


Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile 
        435                 440                 445             


Ser Arg Ser Pro Gly Lys 
    450                 


<210>  47
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  47

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  48
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
145                 150                 155                 160 


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
            180                 185                 190         


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
        195                 200                 205             


Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 220 


<210>  49
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  49

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Pro Tyr Tyr Asp Ser Asn His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Leu Thr Val Ser Ser 
        115                 120     


<210>  50
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  50

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Pro Tyr Tyr Asp Ser Asn His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
    290                 295                 300                 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
305                 310                 315                 320 


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
            340                 345                 350         


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
        355                 360                 365             


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
    370                 375                 380                 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
                405                 410                 415     


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445 


<210>  51
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  51

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Arg Ser Ser Ile Asn Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  52
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  52

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Arg Ser Ser Ile Asn Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  53
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  53

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Leu Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Gly Gly Asp Asn Thr Tyr Tyr Ala Gly Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Phe Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile His Trp Pro Tyr Tyr Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  54
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  54

Gly Ala Cys Gly Thr Gly Ala Ala Gly Cys Thr Cys Gly Thr Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr 
            20                  25                  30          


Ala Gly Thr Gly Ala Ala Gly Cys Thr Thr Gly Gly Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Cys Thr Gly Ala Ala Ala Cys Thr Cys Thr Cys Cys Thr 
    50                  55                  60                  


Gly Thr Gly Thr Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Thr Thr 
65                  70                  75                  80  


Cys Ala Cys Thr Thr Thr Cys Ala Gly Thr Ala Gly Cys Thr Ala Thr 
                85                  90                  95      


Thr Ala Cys Ala Thr Gly Thr Cys Thr Thr Gly Gly Gly Thr Thr Cys 
            100                 105                 110         


Gly Cys Cys Ala Gly Ala Cys Thr Cys Cys Gly Gly Ala Gly Ala Ala 
        115                 120                 125             


Gly Ala Gly Gly Cys Thr Gly Gly Ala Gly Thr Gly Gly Gly Thr Cys 
    130                 135                 140                 


Gly Cys Gly Ala Cys Cys Ala Thr Ala Ala Gly Thr Gly Ala Thr Gly 
145                 150                 155                 160 


Gly Thr Gly Gly Thr Gly Ala Thr Ala Ala Cys Ala Cys Cys Thr Ala 
                165                 170                 175     


Cys Thr Ala Cys Gly Cys Ala Gly Gly Cys Ala Cys Thr Gly Thr Gly 
            180                 185                 190         


Ala Cys Gly Gly Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Thr Cys Cys Ala Gly Ala Gly Ala Cys Thr Thr Thr Gly Cys 
    210                 215                 220                 


Cys Ala Ala Gly Ala Ala Cys Ala Cys Cys Cys Thr Gly Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Thr Cys 
                245                 250                 255     


Thr Gly Ala Cys Cys Thr Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Ala Gly Cys Cys Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Ala Ala Gly Ala Ala Thr Thr Cys Ala Thr Thr Gly Gly Cys 
    290                 295                 300                 


Cys Thr Thr Ala Cys Thr Ala Thr Thr Thr Thr Gly Ala Cys Thr Cys 
305                 310                 315                 320 


Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Cys Ala Cys Cys 
                325                 330                 335     


Ala Cys Thr Cys Thr Cys Ala Cys Ala Gly Thr Cys Thr Cys Cys Thr 
            340                 345                 350         


Cys Ala 
        


<210>  55
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  55

Gln Phe Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Met Leu Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asp Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser His Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105     


<210>  56
<211>  318
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  56

Cys Ala Ala Thr Thr Thr Gly Thr Thr Cys Thr Cys Thr Cys Cys Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Cys Cys Ala Gly Cys Ala Ala Thr Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Thr Gly Cys Ala Thr Cys Thr Cys Cys Cys Gly Gly Gly 
        35                  40                  45              


Gly Ala Gly Ala Thr Gly Cys Thr Cys Ala Cys Ala Ala Thr Gly Ala 
    50                  55                  60                  


Cys Thr Thr Gly Cys Ala Gly Gly Gly Cys Cys Ala Gly Cys Thr Cys 
65                  70                  75                  80  


Ala Ala Gly Thr Gly Thr Ala Ala Gly Thr Thr Ala Thr Ala Thr Gly 
                85                  90                  95      


Ala Ala Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala 
            100                 105                 110         


Ala Gly Cys Cys Ala Gly Gly Ala Thr Cys Thr Thr Cys Cys Cys Cys 
        115                 120                 125             


Cys Ala Ala Ala Cys Cys Cys Thr Gly Gly Ala Thr Thr Thr Ala Thr 
    130                 135                 140                 


Gly Cys Cys Ala Cys Ala Thr Cys Cys Gly Ala Cys Cys Thr Gly Gly 
145                 150                 155                 160 


Cys Thr Thr Cys Thr Gly Gly Ala Gly Thr Cys Cys Cys Thr Gly Cys 
                165                 170                 175     


Thr Cys Gly Cys Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr 
            180                 185                 190         


Gly Gly Gly Thr Cys Thr Gly Gly Gly Ala Cys Cys Thr Cys Thr Thr 
        195                 200                 205             


Ala Thr Thr Cys Thr Cys Thr Cys Ala Cys Ala Ala Thr Cys Ala Gly 
    210                 215                 220                 


Cys Ala Gly Ala Gly Thr Gly Gly Ala Gly Gly Cys Thr Gly Ala Ala 
225                 230                 235                 240 


Gly Ala Thr Gly Cys Thr Gly Cys Cys Ala Cys Thr Thr Ala Thr Thr 
                245                 250                 255     


Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Thr Gly Gly Ala Gly 
            260                 265                 270         


Thr Ala Gly Thr Cys Ala Cys Cys Cys Ala Cys Cys Cys Ala Cys Gly 
        275                 280                 285             


Thr Thr Cys Gly Gly Ala Gly Gly Gly Gly Gly Gly Ala Cys Cys Ala 
    290                 295                 300                 


Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Ala Ala Gly Ala 
305                 310                 315             


