                         SEQUENCE LISTING

<110>  LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC
 
<120>  YEAST EXPRESSING THERMO-TOLERANT ALPHA AMYLASES FOR HYDROLYSIS OF
        STARCH

<130>  55729550-28PCT

<150>  US62/642542
<151>  2018-03-13

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  463
<212>  PRT
<213>  Thermococcus gammatolerans

<400>  1




Leu Ala Gly Leu Tyr Tyr Pro Ser Ala Ser Ala Ala Lys Tyr Ser Glu 
            20                  25                  30          


Leu Glu Gln Gly Gly Val Ile Met Gln Ala Phe Tyr Trp Asp Val Pro 
        35                  40                  45              


Ala Gly Gly Ile Trp Trp Asp Thr Ile Arg Gln Lys Ile Pro Glu Trp 
    50                  55                  60                  


Tyr Asp Ala Gly Ile Ser Ala Ile Trp Ile Pro Pro Ala Ser Lys Gly 
65                  70                  75                  80  


Met Gly Gly Ala Tyr Ser Met Gly Tyr Asp Pro Tyr Asp Tyr Phe Asp 
                85                  90                  95      


Leu Gly Glu Phe Tyr Gln Lys Gly Thr Val Glu Thr Arg Phe Gly Ser 
            100                 105                 110         


Lys Glu Glu Leu Val Asn Met Ile Ser Thr Ala His Arg Tyr Gly Ile 
        115                 120                 125             


Lys Val Ile Ala Asp Ile Val Ile Asn His Arg Ala Gly Gly Asp Leu 
    130                 135                 140                 


Glu Trp Asn Pro Tyr Val Gly Asp Tyr Thr Trp Thr Asp Phe Ser Gln 
145                 150                 155                 160 


Val Ala Ser Gly Lys Tyr Lys Ala His Tyr Met Asp Phe His Pro Asn 
                165                 170                 175     


Asn Tyr Ser Thr Ser Asp Glu Gly Thr Phe Gly Gly Phe Pro Asp Ile 
            180                 185                 190         


Asp His Leu Val Pro Phe Asn Lys Tyr Trp Leu Trp Ala Ser Asp Glu 
        195                 200                 205             


Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Val Asp Ala Trp Arg Phe 
    210                 215                 220                 


Asp Tyr Val Lys Gly Tyr Gly Ala Trp Val Val Lys Asp Trp Leu Ser 
225                 230                 235                 240 


Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp Thr Asp Val Asn 
                245                 250                 255     


Ala Leu Leu Asn Trp Ala Tyr Asp Ser Gly Ala Lys Val Phe Asp Phe 
            260                 265                 270         


Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn Lys Asn Ile Pro 
        275                 280                 285             


Ala Leu Val Tyr Ala Ile Gln Asn Gly Gly Thr Val Val Ser Arg Asp 
    290                 295                 300                 


Pro Phe Lys Ala Val Thr Phe Val Ala Asn His Asp Thr Asn Ile Ile 
305                 310                 315                 320 


Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr Tyr Glu Gly Gln 
                325                 330                 335     


Pro Val Ile Phe Tyr Arg Asp Tyr Glu Glu Trp Leu Asn Lys Asp Lys 
            340                 345                 350         


Leu Asn Asn Leu Ile Trp Ile His Glu His Leu Ala Gly Gly Ser Thr 
        355                 360                 365             


Lys Ile Leu Tyr Tyr Asp Asp Asp Glu Leu Ile Phe Met Arg Glu Gly 
    370                 375                 380                 


Tyr Gly Asp Arg Pro Gly Leu Ile Thr Tyr Ile Asn Leu Gly Ser Gly 
385                 390                 395                 400 


Trp Ala Glu Arg Trp Val Asn Val Gly Ser Lys Phe Ala Gly Tyr Thr 
                405                 410                 415     


Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Val Asp Arg Tyr Val 
            420                 425                 430         


Tyr Tyr Asn Gly Trp Val Lys Leu Thr Ala Pro Pro His Asp Pro Ala 
        435                 440                 445             


Asn Gly Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr Ala Gly Val Gly 
    450                 455                 460             


<210>  2
<211>  457
<212>  PRT
<213>  Thermococcus thioreducens

<400>  2

Met Ala Arg Lys Val Thr Val Ala Leu Leu Val Leu Leu Val Val Leu 
1               5                   10                  15      


Ser Leu Ser Ala Val Pro Ala Lys Ala Glu Thr Leu Glu Asn Gly Gly 
            20                  25                  30          


Val Ile Met Gln Ala Phe Tyr Trp Asp Val Pro Met Gly Gly Ile Trp 
        35                  40                  45              


Trp Asp Thr Ile Ala Gln Lys Ile Pro Asp Trp Ala Ser Ala Gly Ile 
    50                  55                  60                  


Ser Ala Ile Trp Ile Pro Pro Ala Ser Lys Gly Met Ser Gly Gly Tyr 
65                  70                  75                  80  


Ser Met Gly Tyr Asp Pro Tyr Asp Tyr Phe Asp Leu Gly Glu Tyr Tyr 
                85                  90                  95      


Gln Lys Gly Thr Val Glu Thr Arg Phe Gly Ser Lys Gln Glu Leu Val 
            100                 105                 110         


Asn Met Ile Asn Thr Ala His Ala Tyr Gly Met Lys Val Ile Ala Asp 
        115                 120                 125             


Ile Val Ile Asn His Arg Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe 
    130                 135                 140                 


Val Asn Asp Tyr Thr Trp Thr Asp Phe Ser Lys Val Ala Ser Gly Lys 
145                 150                 155                 160 


Tyr Thr Ala Asn Tyr Leu Asp Phe His Pro Asn Glu Leu His Ala Gly 
                165                 170                 175     


Asp Ser Gly Thr Phe Gly Gly Tyr Pro Asp Ile Cys His Asp Lys Ser 
            180                 185                 190         


Trp Asp Gln Tyr Trp Leu Trp Ala Ser Asn Glu Ser Tyr Ala Ala Tyr 
        195                 200                 205             


Leu Arg Ser Ile Gly Ile Asp Ala Trp Arg Phe Asp Tyr Val Lys Gly 
    210                 215                 220                 


Tyr Ala Pro Trp Val Val Lys Asp Trp Leu Asn Trp Trp Gly Gly Trp 
225                 230                 235                 240 


Ala Val Gly Glu Tyr Trp Asp Thr Asn Val Asp Ala Leu Leu Asn Trp 
                245                 250                 255     


Ala Tyr Ala Ser Gly Ala Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys 
            260                 265                 270         


Met Asp Glu Ala Phe Asp Asn Asn Asn Ile Pro Ala Leu Val Asp Ala 
        275                 280                 285             


Leu Arg Tyr Gly Gln Thr Val Val Ser Arg Asp Pro Phe Lys Ala Val 
    290                 295                 300                 


Thr Phe Val Ala Asn His Asp Thr Asp Ile Ile Trp Asn Lys Tyr Pro 
305                 310                 315                 320 


Ala Tyr Ala Phe Ile Leu Thr Tyr Glu Gly Gln Pro Met Ile Phe Tyr 
                325                 330                 335     


Arg Asp Tyr Glu Glu Trp Leu Asn Lys Asp Arg Leu Lys Asn Leu Ile 
            340                 345                 350         


Trp Ile His Asp His Leu Ala Gly Gly Ser Thr Asp Ile Val Tyr Tyr 
        355                 360                 365             


Asp Ser Asp Glu Leu Ile Phe Val Arg Asn Gly Tyr Gly Ser Lys Pro 
    370                 375                 380                 


Gly Leu Ile Thr Tyr Ile Asn Leu Gly Ser Ser Lys Ala Gly Arg Trp 
385                 390                 395                 400 


Val Tyr Val Pro Lys Phe Ala Gly Ser Cys Ile His Glu Tyr Thr Gly 
                405                 410                 415     


Asn Leu Gly Gly Trp Val Asp Lys Trp Val Asp Ser Ser Gly Trp Val 
            420                 425                 430         


Tyr Leu Glu Ala Pro Ala His Asp Pro Ala Asn Gly Gln Tyr Gly Tyr 
        435                 440                 445             


Ser Val Trp Ser Tyr Cys Gly Val Gly 
    450                 455         


<210>  3
<211>  461
<212>  PRT
<213>  thermococcus eurythermalis

<400>  3

Met Lys Pro Ala Lys Leu Leu Val Phe Val Leu Val Val Ser Ile Leu 
1               5                   10                  15      


Ala Gly Leu Tyr Ala Gln Pro Ala Gly Ala Ala Lys Tyr Leu Glu Leu 
            20                  25                  30          


Glu Glu Gly Gly Val Ile Met Gln Ala Phe Tyr Trp Asp Val Pro Ser 
        35                  40                  45              


Gly Gly Ile Trp Trp Asp Thr Ile Arg Gln Lys Ile Pro Glu Trp Tyr 
    50                  55                  60                  


Asp Ala Gly Ile Ser Ala Ile Trp Ile Pro Pro Ala Ser Lys Gly Met 
65                  70                  75                  80  


Gly Gly Ala Tyr Ser Met Gly Tyr Asp Pro Tyr Asp Phe Phe Asp Leu 
                85                  90                  95      


Gly Glu Tyr Asp Gln Lys Gly Thr Val Glu Thr Arg Phe Gly Ser Lys 
            100                 105                 110         


Gln Glu Leu Val Asn Met Ile Asn Thr Ala His Ala Tyr Gly Ile Lys 
        115                 120                 125             


Val Ile Ala Asp Ile Val Ile Asn His Arg Ala Gly Gly Asp Leu Glu 
    130                 135                 140                 


Trp Asn Pro Phe Val Asn Asp Tyr Thr Trp Thr Asp Phe Ser Lys Val 
145                 150                 155                 160 


Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu Asp Phe His Pro Asn Glu 
                165                 170                 175     


Val Lys Cys Cys Asp Glu Gly Thr Phe Gly Gly Phe Pro Asp Ile Ala 
            180                 185                 190         


His Glu Lys Ser Trp Asp Gln Tyr Trp Leu Trp Ala Ser Asn Glu Ser 
        195                 200                 205             


Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Val Asp Ala Trp Arg Phe Asp 
    210                 215                 220                 


Tyr Val Lys Gly Tyr Gly Ala Trp Val Val Lys Asp Trp Leu Asp Trp 
225                 230                 235                 240 


Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp Thr Asn Val Asp Ala 
                245                 250                 255     


Leu Leu Asn Trp Ala Tyr Ser Ser Asp Ala Lys Val Phe Asp Phe Pro 
            260                 265                 270         


Leu Tyr Tyr Lys Met Asp Ala Ala Phe Asp Asn Lys Asn Ile Pro Ala 
        275                 280                 285             


Leu Val Glu Ala Leu Lys Asn Gly Gly Thr Val Val Ser Arg Asp Pro 
    290                 295                 300                 


Phe Lys Ala Val Thr Phe Val Ala Asn His Asp Thr Asp Ile Ile Trp 
305                 310                 315                 320 


Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr Tyr Glu Gly Gln Pro 
                325                 330                 335     


Thr Ile Phe Tyr Arg Asp Tyr Glu Glu Trp Leu Asn Lys Asp Arg Leu 
            340                 345                 350         


Lys Asn Leu Ile Trp Ile His Asp His Leu Ala Gly Gly Ser Thr Asp 
        355                 360                 365             


Ile Val Tyr Tyr Asp Asn Asp Glu Leu Ile Phe Val Arg Asn Gly Tyr 
    370                 375                 380                 


Gly Asp Lys Pro Gly Leu Ile Thr Tyr Ile Asn Leu Gly Ser Ser Lys 
385                 390                 395                 400 


Ala Gly Arg Trp Val Tyr Val Pro Lys Phe Ala Gly Ala Cys Ile His 
                405                 410                 415     


Glu Tyr Thr Gly Asn Leu Gly Gly Trp Val Asp Lys Trp Val Asp Ser 
            420                 425                 430         


Ser Gly Trp Val Tyr Leu Glu Ala Pro Ala His Asp Pro Ala Asn Gly 
        435                 440                 445             


Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr Cys Gly Val Gly 
    450                 455                 460     


<210>  4
<211>  457
<212>  PRT
<213>  Thermococcus hydrothermalis

<400>  4

Met Ala Arg Lys Val Leu Val Ala Leu Leu Val Phe Leu Val Val Leu 
1               5                   10                  15      


Ser Val Ser Ala Val Pro Ala Lys Ala Glu Thr Leu Glu Asn Gly Gly 
            20                  25                  30          


Val Ile Met Gln Ala Phe Tyr Trp Asp Val Pro Gly Gly Gly Ile Trp 
        35                  40                  45              


Trp Asp Thr Ile Ala Gln Lys Ile Pro Asp Trp Ala Ser Ala Gly Ile 
    50                  55                  60                  


Ser Ala Ile Trp Ile Pro Pro Ala Ser Lys Gly Met Ser Gly Gly Tyr 
65                  70                  75                  80  


Ser Met Gly Tyr Asp Pro Tyr Asp Phe Phe Asp Leu Gly Glu Tyr Tyr 
                85                  90                  95      


Gln Lys Gly Ser Val Glu Thr Arg Phe Gly Ser Lys Glu Glu Leu Val 
            100                 105                 110         


Asn Met Ile Asn Thr Ala His Ala His Asn Met Lys Val Ile Ala Asp 
        115                 120                 125             


Ile Val Ile Asn His Arg Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe 
    130                 135                 140                 


Thr Asn Ser Tyr Thr Trp Thr Asp Phe Ser Lys Val Ala Ser Gly Lys 
145                 150                 155                 160 


Tyr Thr Ala Asn Tyr Leu Asp Phe His Pro Asn Glu Leu His Ala Gly 
                165                 170                 175     


Asp Ser Gly Thr Phe Gly Gly Tyr Pro Asp Ile Cys His Asp Lys Ser 
            180                 185                 190         


Trp Asp Gln His Trp Leu Trp Ala Ser Asn Glu Ser Tyr Ala Ala Tyr 
        195                 200                 205             


Leu Arg Ser Ile Gly Ile Asp Ala Trp Arg Phe Asp Tyr Val Lys Gly 
    210                 215                 220                 


Tyr Ala Pro Trp Val Val Lys Asn Trp Leu Asn Arg Trp Gly Gly Trp 
225                 230                 235                 240 


Ala Val Gly Glu Tyr Trp Asp Thr Asn Val Asp Ala Leu Leu Ser Trp 
                245                 250                 255     


Ala Tyr Asp Ser Gly Ala Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys 
            260                 265                 270         


Met Asp Glu Ala Phe Asp Asn Asn Asn Ile Pro Ala Leu Val Asp Ala 
        275                 280                 285             


Leu Lys Asn Gly Gly Thr Val Val Ser Arg Asp Pro Phe Lys Ala Val 
    290                 295                 300                 


Thr Phe Val Ala Asn His Asp Thr Asn Ile Ile Trp Asn Lys Tyr Pro 
305                 310                 315                 320 


Ala Tyr Ala Phe Ile Leu Thr Tyr Glu Gly Gln Pro Ala Ile Phe Tyr 
                325                 330                 335     


Arg Asp Tyr Glu Glu Trp Leu Asn Lys Asp Arg Leu Arg Asn Leu Ile 
            340                 345                 350         


Trp Ile His Asp His Leu Ala Gly Gly Ser Thr Asp Ile Ile Tyr Tyr 
        355                 360                 365             


Asp Ser Asp Glu Leu Ile Phe Val Arg Asn Gly Tyr Gly Asp Lys Pro 
    370                 375                 380                 


Gly Leu Ile Thr Tyr Ile Asn Leu Gly Ser Ser Lys Ala Gly Arg Trp 
385                 390                 395                 400 


Val Tyr Val Pro Lys Phe Ala Gly Ser Cys Ile His Glu Tyr Thr Gly 
                405                 410                 415     


Asn Leu Gly Gly Trp Ile Asp Lys Trp Val Asp Ser Ser Gly Arg Val 
            420                 425                 430         


Tyr Leu Glu Ala Pro Ala His Asp Pro Ala Asn Gly Gln Tyr Gly Tyr 
        435                 440                 445             


Ser Val Trp Ser Tyr Cys Gly Val Gly 
    450                 455         


<210>  5
<211>  460
<212>  PRT
<213>  Pyrococcus furiosus

<400>  5

Met Asn Ile Lys Lys Leu Thr Pro Leu Leu Thr Leu Leu Leu Phe Phe 
1               5                   10                  15      


Ile Val Leu Ala Ser Pro Val Ser Ala Ala Lys Tyr Leu Glu Leu Glu 
            20                  25                  30          


Glu Gly Gly Val Ile Met Gln Ala Phe Tyr Trp Asp Val Pro Gly Gly 
        35                  40                  45              


Gly Ile Trp Trp Asp His Ile Arg Ser Lys Ile Pro Glu Trp Tyr Glu 
    50                  55                  60                  


Ala Gly Ile Ser Ala Ile Trp Leu Pro Pro Pro Ser Lys Gly Met Ser 
65                  70                  75                  80  


Gly Gly Tyr Ser Met Gly Tyr Asp Pro Tyr Asp Tyr Phe Asp Leu Gly 
                85                  90                  95      


Glu Tyr Tyr Gln Lys Gly Thr Val Glu Thr Arg Phe Gly Ser Lys Glu 
            100                 105                 110         


Glu Leu Val Arg Leu Ile Gln Thr Ala His Ala Tyr Gly Ile Lys Val 
        115                 120                 125             


Ile Ala Asp Val Val Ile Asn His Arg Ala Gly Gly Asp Leu Glu Trp 
    130                 135                 140                 


Asn Pro Phe Val Gly Asp Tyr Thr Trp Thr Asp Phe Ser Lys Val Ala 
145                 150                 155                 160 


Ser Gly Lys Tyr Thr Ala Asn Tyr Leu Asp Phe His Pro Asn Glu Leu 
                165                 170                 175     


His Cys Cys Asp Glu Gly Thr Phe Gly Gly Phe Pro Asp Ile Cys His 
            180                 185                 190         


His Lys Glu Trp Asp Gln Tyr Trp Leu Trp Lys Ser Asn Glu Ser Tyr 
        195                 200                 205             


Ala Ala Tyr Leu Arg Ser Ile Gly Phe Asp Gly Trp Arg Phe Asp Tyr 
    210                 215                 220                 


Val Lys Gly Tyr Gly Ala Trp Val Val Arg Asp Trp Leu Asn Trp Trp 
225                 230                 235                 240 


Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp Thr Asn Val Asp Ala Leu 
                245                 250                 255     


Leu Ser Trp Ala Tyr Glu Ser Gly Ala Lys Val Phe Asp Phe Pro Leu 
            260                 265                 270         


Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn Asn Asn Ile Pro Ala Leu 
        275                 280                 285             


Val Tyr Ala Leu Gln Asn Gly Gln Thr Val Val Ser Arg Asp Pro Phe 
    290                 295                 300                 


Lys Ala Val Thr Phe Val Ala Asn His Asp Thr Asp Ile Ile Trp Asn 
305                 310                 315                 320 


Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr Tyr Glu Gly Gln Pro Val 
                325                 330                 335     


Ile Phe Tyr Arg Asp Phe Glu Glu Trp Leu Asn Lys Asp Lys Leu Ile 
            340                 345                 350         


Asn Leu Ile Trp Ile His Asp His Leu Ala Gly Gly Ser Thr Thr Ile 
        355                 360                 365             


Val Tyr Tyr Asp Asn Asp Glu Leu Ile Phe Val Arg Asn Gly Asp Ser 
    370                 375                 380                 


Arg Arg Pro Gly Leu Ile Thr Tyr Ile Asn Leu Ser Pro Asn Trp Val 
385                 390                 395                 400 


Gly Arg Trp Val Tyr Val Pro Lys Phe Ala Gly Ala Cys Ile His Glu 
                405                 410                 415     


Tyr Thr Gly Asn Leu Gly Gly Trp Val Asp Lys Arg Val Asp Ser Ser 
            420                 425                 430         


Gly Trp Val Tyr Leu Glu Ala Pro Pro His Asp Pro Ala Asn Gly Tyr 
        435                 440                 445             


Tyr Gly Tyr Ser Val Trp Ser Tyr Cys Gly Val Gly 
    450                 455                 460 


<210>  6
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SED1 tether


<220>
<221>  CDS
<222>  (1)..(807)

<400>  6
aag gac aat agc tcg acg att gaa ggt aga tac cca tac gac gtt cca         48
Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro           
1               5                   10                  15                

gac tac gct ctg cag gct agt ggt ggt ggt ggt tct ggt ggt ggt ggt         96
Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
            20                  25                  30                    

tct ggt ggt ggt ggt tct gct agc gct ctt cca act aac ggt act tct        144
Ser Gly Gly Gly Gly Ser Ala Ser Ala Leu Pro Thr Asn Gly Thr Ser           
        35                  40                  45                        

act gaa gct cca act gat act act act gaa gct cca acc acc ggt ctt        192
Thr Glu Ala Pro Thr Asp Thr Thr Thr Glu Ala Pro Thr Thr Gly Leu           
    50                  55                  60                            

cca acc aac ggt acc act tca gct ttc cca cca act aca tct ttg cca        240
Pro Thr Asn Gly Thr Thr Ser Ala Phe Pro Pro Thr Thr Ser Leu Pro           
65                  70                  75                  80            

cca agc aac act acc acc act cct cct tac aac cca tct act gac tac        288
Pro Ser Asn Thr Thr Thr Thr Pro Pro Tyr Asn Pro Ser Thr Asp Tyr           
                85                  90                  95                

acc act gac tac act gta gtc act gaa tat act act tac tgt cca gaa        336
Thr Thr Asp Tyr Thr Val Val Thr Glu Tyr Thr Thr Tyr Cys Pro Glu           
            100                 105                 110                   

cca acc act ttc acc aca aac ggt aag act tac acc gtc act gaa cca        384
Pro Thr Thr Phe Thr Thr Asn Gly Lys Thr Tyr Thr Val Thr Glu Pro           
        115                 120                 125                       

acc aca ttg act atc act gac tgt cca tgc acc att gaa aag cca aca        432
Thr Thr Leu Thr Ile Thr Asp Cys Pro Cys Thr Ile Glu Lys Pro Thr           
    130                 135                 140                           

acc aca tca acc acc gaa tac act gta gtc act gag tac act act tac        480
Thr Thr Ser Thr Thr Glu Tyr Thr Val Val Thr Glu Tyr Thr Thr Tyr           
145                 150                 155                 160           

tgt cca gaa cca acc act ttc acc aca aac ggt aag act tac acc gtc        528
Cys Pro Glu Pro Thr Thr Phe Thr Thr Asn Gly Lys Thr Tyr Thr Val           
                165                 170                 175               

act gaa cca acc act ttg act atc act gac tgt cca tgt act att gaa        576
Thr Glu Pro Thr Thr Leu Thr Ile Thr Asp Cys Pro Cys Thr Ile Glu           
            180                 185                 190                   

aag agc gaa gcc cct gag tct tct gtc cca gtt acc gaa tct aag ggc        624
Lys Ser Glu Ala Pro Glu Ser Ser Val Pro Val Thr Glu Ser Lys Gly           
        195                 200                 205                       

act acc acc aaa gaa aca ggt gtt act acc aaa caa acc aca gcc aac        672
Thr Thr Thr Lys Glu Thr Gly Val Thr Thr Lys Gln Thr Thr Ala Asn           
    210                 215                 220                           

cca agt cta acc gtc tcc aca gtc gtc cca gtt tca tcc tct gct tct        720
Pro Ser Leu Thr Val Ser Thr Val Val Pro Val Ser Ser Ser Ala Ser           
225                 230                 235                 240           

tct cat tcc gtt gtc atc aac agt aac ggt gct aac gtc gtc gtt cca        768
Ser His Ser Val Val Ile Asn Ser Asn Gly Ala Asn Val Val Val Pro           
                245                 250                 255               

ggt gct tta ggt ttg gct ggt gtt gct atg tta ttc taa                    807
Gly Ala Leu Gly Leu Ala Gly Val Ala Met Leu Phe                           
            260                 265                                       


<210>  7
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Ala Ser Ala Leu Pro Thr Asn Gly Thr Ser 
        35                  40                  45              


Thr Glu Ala Pro Thr Asp Thr Thr Thr Glu Ala Pro Thr Thr Gly Leu 
    50                  55                  60                  


Pro Thr Asn Gly Thr Thr Ser Ala Phe Pro Pro Thr Thr Ser Leu Pro 
65                  70                  75                  80  


Pro Ser Asn Thr Thr Thr Thr Pro Pro Tyr Asn Pro Ser Thr Asp Tyr 
                85                  90                  95      


Thr Thr Asp Tyr Thr Val Val Thr Glu Tyr Thr Thr Tyr Cys Pro Glu 
            100                 105                 110         


Pro Thr Thr Phe Thr Thr Asn Gly Lys Thr Tyr Thr Val Thr Glu Pro 
        115                 120                 125             


Thr Thr Leu Thr Ile Thr Asp Cys Pro Cys Thr Ile Glu Lys Pro Thr 
    130                 135                 140                 


Thr Thr Ser Thr Thr Glu Tyr Thr Val Val Thr Glu Tyr Thr Thr Tyr 
145                 150                 155                 160 


Cys Pro Glu Pro Thr Thr Phe Thr Thr Asn Gly Lys Thr Tyr Thr Val 
                165                 170                 175     


Thr Glu Pro Thr Thr Leu Thr Ile Thr Asp Cys Pro Cys Thr Ile Glu 
            180                 185                 190         


Lys Ser Glu Ala Pro Glu Ser Ser Val Pro Val Thr Glu Ser Lys Gly 
        195                 200                 205             


Thr Thr Thr Lys Glu Thr Gly Val Thr Thr Lys Gln Thr Thr Ala Asn 
    210                 215                 220                 


Pro Ser Leu Thr Val Ser Thr Val Val Pro Val Ser Ser Ser Ala Ser 
225                 230                 235                 240 


Ser His Ser Val Val Ile Asn Ser Asn Gly Ala Asn Val Val Val Pro 
                245                 250                 255     


Gly Ala Leu Gly Leu Ala Gly Val Ala Met Leu Phe 
            260                 265             


<210>  8
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPI1 tether


<220>
<221>  CDS
<222>  (1)..(390)

<400>  8
ttg gta tct aat tct agt tcc tct gta atc gtg gta cca tca agc gat         48
Leu Val Ser Asn Ser Ser Ser Ser Val Ile Val Val Pro Ser Ser Asp           
1               5                   10                  15                

gct act att gcc ggt aac gat aca gcc acg cca gca cca gag cca tca         96
Ala Thr Ile Ala Gly Asn Asp Thr Ala Thr Pro Ala Pro Glu Pro Ser           
            20                  25                  30                    

tcc gcc gct cca ata ttc tac aac tcg act gct act gca aca cag tac        144
Ser Ala Ala Pro Ile Phe Tyr Asn Ser Thr Ala Thr Ala Thr Gln Tyr           
        35                  40                  45                        

gaa gtt gtc agt gaa ttc act act tac tgc cca gaa cca acg act ttc        192
Glu Val Val Ser Glu Phe Thr Thr Tyr Cys Pro Glu Pro Thr Thr Phe           
    50                  55                  60                            

gta acg aat ggc gct aca ttc act gtt act gcc cca act acg tta aca        240
Val Thr Asn Gly Ala Thr Phe Thr Val Thr Ala Pro Thr Thr Leu Thr           
65                  70                  75                  80            

att acc aac tgt cct tgc act atc gag aag cct act tca gaa aca tcg        288
Ile Thr Asn Cys Pro Cys Thr Ile Glu Lys Pro Thr Ser Glu Thr Ser           
                85                  90                  95                

gtt tct tct aca cat gat gtg gag aca aat tct aat gct gct aac gca        336
Val Ser Ser Thr His Asp Val Glu Thr Asn Ser Asn Ala Ala Asn Ala           
            100                 105                 110                   

aga gca atc cca gga gcc cta ggt ttg gct ggt gca gtt atg atg ctt        384
Arg Ala Ile Pro Gly Ala Leu Gly Leu Ala Gly Ala Val Met Met Leu           
        115                 120                 125                       

tta tga                                                                390
Leu                                                                       
                                                                          


<210>  9
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Leu Val Ser Asn Ser Ser Ser Ser Val Ile Val Val Pro Ser Ser Asp 
1               5                   10                  15      


Ala Thr Ile Ala Gly Asn Asp Thr Ala Thr Pro Ala Pro Glu Pro Ser 
            20                  25                  30          


Ser Ala Ala Pro Ile Phe Tyr Asn Ser Thr Ala Thr Ala Thr Gln Tyr 
        35                  40                  45              


Glu Val Val Ser Glu Phe Thr Thr Tyr Cys Pro Glu Pro Thr Thr Phe 
    50                  55                  60                  


Val Thr Asn Gly Ala Thr Phe Thr Val Thr Ala Pro Thr Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Asn Cys Pro Cys Thr Ile Glu Lys Pro Thr Ser Glu Thr Ser 
                85                  90                  95      


Val Ser Ser Thr His Asp Val Glu Thr Asn Ser Asn Ala Ala Asn Ala 
            100                 105                 110         


Arg Ala Ile Pro Gly Ala Leu Gly Leu Ala Gly Ala Val Met Met Leu 
        115                 120                 125             


Leu 
    


<210>  10
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCW12 tether


<220>
<221>  CDS
<222>  (1)..(339)

<400>  10
gtt acc act gct act gtc agc caa gaa tct acc act ttg gtc acc atc         48
Val Thr Thr Ala Thr Val Ser Gln Glu Ser Thr Thr Leu Val Thr Ile           
1               5                   10                  15                

act tct tgt gaa gac cac gtc tgt tct gaa act gtc tcc cca gct ttg         96
Thr Ser Cys Glu Asp His Val Cys Ser Glu Thr Val Ser Pro Ala Leu           
            20                  25                  30                    

gtt tcc acc gct acc gtc acc gtc gat gac gtt atc act caa tac acc        144
Val Ser Thr Ala Thr Val Thr Val Asp Asp Val Ile Thr Gln Tyr Thr           
        35                  40                  45                        

acc tgg tgc cca ttg acc act gaa gcc cca aag aac ggt act tct act        192
Thr Trp Cys Pro Leu Thr Thr Glu Ala Pro Lys Asn Gly Thr Ser Thr           
    50                  55                  60                            

gct gct cca gtt acc tct act gaa gct cca aag aac acc acc tct gct        240
Ala Ala Pro Val Thr Ser Thr Glu Ala Pro Lys Asn Thr Thr Ser Ala           
65                  70                  75                  80            

gct cca act cac tct gtc acc tct tac act ggt gct gct gct aag gct        288
Ala Pro Thr His Ser Val Thr Ser Tyr Thr Gly Ala Ala Ala Lys Ala           
                85                  90                  95                

ttg cca gct gct ggt gct ttg ttg gct ggt gcc gct gct ttg ttg ttg        336
Leu Pro Ala Ala Gly Ala Leu Leu Ala Gly Ala Ala Ala Leu Leu Leu           
            100                 105                 110                   

taa                                                                    339


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Val Thr Thr Ala Thr Val Ser Gln Glu Ser Thr Thr Leu Val Thr Ile 
1               5                   10                  15      


Thr Ser Cys Glu Asp His Val Cys Ser Glu Thr Val Ser Pro Ala Leu 
            20                  25                  30          


Val Ser Thr Ala Thr Val Thr Val Asp Asp Val Ile Thr Gln Tyr Thr 
        35                  40                  45              


Thr Trp Cys Pro Leu Thr Thr Glu Ala Pro Lys Asn Gly Thr Ser Thr 
    50                  55                  60                  


Ala Ala Pro Val Thr Ser Thr Glu Ala Pro Lys Asn Thr Thr Ser Ala 
65                  70                  75                  80  


Ala Pro Thr His Ser Val Thr Ser Tyr Thr Gly Ala Ala Ala Lys Ala 
                85                  90                  95      


Leu Pro Ala Ala Gly Ala Leu Leu Ala Gly Ala Ala Ala Leu Leu Leu 
            100                 105                 110         


<210>  12
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CWP2 tether


<220>
<221>  CDS
<222>  (1)..(450)

<400>  12
aag gac aat agc tcg acg att gaa ggt aga tac cca tac gac gtt cca         48
Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro           
1               5                   10                  15                

gac tac gct ctg cag gct agt ggt ggt ggt ggt tct ggt ggt ggt ggt         96
Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
            20                  25                  30                    

tct ggt ggt ggt ggt tct gct agc gga tcc ggt ggc ggt gga tct gga        144
Ser Gly Gly Gly Gly Ser Ala Ser Gly Ser Gly Gly Gly Gly Ser Gly           
        35                  40                  45                        

gga ggc ggt tct tgg tct cac cca caa ttt gaa aag ggt gga gaa aac        192
Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys Gly Gly Glu Asn           
    50                  55                  60                            

ttg tac ttt caa ggc ggt ggt gga ggt tct ggc gga ggt ggc tcc ggc        240
Leu Tyr Phe Gln Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly           
65                  70                  75                  80            

tca gct atc tct caa atc acc gac ggt caa atc caa gcc act acc aca        288
Ser Ala Ile Ser Gln Ile Thr Asp Gly Gln Ile Gln Ala Thr Thr Thr           
                85                  90                  95                

gct acc act gaa gct aca act acc gct gct cct tca tct act gtt gaa        336
Ala Thr Thr Glu Ala Thr Thr Thr Ala Ala Pro Ser Ser Thr Val Glu           
            100                 105                 110                   

act gtt tct cca tct tcc acc gaa acc atc tct caa caa acc gaa aac        384
Thr Val Ser Pro Ser Ser Thr Glu Thr Ile Ser Gln Gln Thr Glu Asn           
        115                 120                 125                       

ggt gct gct aag gct gct gtt ggt atg ggt gct ggt gct ttg gct gct        432
Gly Ala Ala Lys Ala Ala Val Gly Met Gly Ala Gly Ala Leu Ala Ala           
    130                 135                 140                           

gct gct atg ttg ttg taa                                                450
Ala Ala Met Leu Leu                                                       
145                                                                       


<210>  13
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Ala Ser Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys Gly Gly Glu Asn 
    50                  55                  60                  


Leu Tyr Phe Gln Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
65                  70                  75                  80  


Ser Ala Ile Ser Gln Ile Thr Asp Gly Gln Ile Gln Ala Thr Thr Thr 
                85                  90                  95      


Ala Thr Thr Glu Ala Thr Thr Thr Ala Ala Pro Ser Ser Thr Val Glu 
            100                 105                 110         


Thr Val Ser Pro Ser Ser Thr Glu Thr Ile Ser Gln Gln Thr Glu Asn 
        115                 120                 125             


Gly Ala Ala Lys Ala Ala Val Gly Met Gly Ala Gly Ala Leu Ala Ala 
    130                 135                 140                 


Ala Ala Met Leu Leu 
145                 


<210>  14
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIR1 tether


<220>
<221>  CDS
<222>  (1)..(759)

<400>  14
aag gac aat agc tcg acg att gaa ggt aga tac cca tac gac gtt cca         48
Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro           
1               5                   10                  15                

gac tac gct ctg cag gct agt ggt ggt ggt ggt tct ggt ggt ggt ggt         96
Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
            20                  25                  30                    

tct ggt ggt ggt ggt tct gct agc agc tta gct tct gat tct tcc tct        144
Ser Gly Gly Gly Gly Ser Ala Ser Ser Leu Ala Ser Asp Ser Ser Ser           
        35                  40                  45                        

gga ttt tcc tta agc agt atg cca gct ggt gtt ttg gat atc ggt atg        192
Gly Phe Ser Leu Ser Ser Met Pro Ala Gly Val Leu Asp Ile Gly Met           
    50                  55                  60                            

gct tta gct tcc gcc act gac gac tcc tac act act ttg tac tct gag        240
Ala Leu Ala Ser Ala Thr Asp Asp Ser Tyr Thr Thr Leu Tyr Ser Glu           
65                  70                  75                  80            

gtt gac ttt gct ggt gtt agc aag atg ttg acc atg gtt cca tgg tac        288
Val Asp Phe Ala Gly Val Ser Lys Met Leu Thr Met Val Pro Trp Tyr           
                85                  90                  95                

tcc tct aga ttg gaa cca gct ttg aag tct ttg aat ggt gat gct tct        336
Ser Ser Arg Leu Glu Pro Ala Leu Lys Ser Leu Asn Gly Asp Ala Ser           
            100                 105                 110                   

tct tct gct gcc cca agc tct tct gct gct cca act tct tct gct gcc        384
Ser Ser Ala Ala Pro Ser Ser Ser Ala Ala Pro Thr Ser Ser Ala Ala           
        115                 120                 125                       

cca agc tca tct gct gcc cca act tct tct gct gcc tca agc tct tct        432
Pro Ser Ser Ser Ala Ala Pro Thr Ser Ser Ala Ala Ser Ser Ser Ser           
    130                 135                 140                           

gaa gct aag tct tct tct gct gcc cca agc tct tct gaa gct aag tct        480
Glu Ala Lys Ser Ser Ser Ala Ala Pro Ser Ser Ser Glu Ala Lys Ser           
145                 150                 155                 160           

tct tct gct gcc cca agc tct tct gaa gct aag tct tct tct gct gcc        528
Ser Ser Ala Ala Pro Ser Ser Ser Glu Ala Lys Ser Ser Ser Ala Ala           
                165                 170                 175               

cca agc tct tct gaa gct aag tct tct tct gct gct cca agc tcc act        576
Pro Ser Ser Ser Glu Ala Lys Ser Ser Ser Ala Ala Pro Ser Ser Thr           
            180                 185                 190                   

gaa gct aag ata act tct gct gct cca agc tcc act ggt gcc aag acc        624
Glu Ala Lys Ile Thr Ser Ala Ala Pro Ser Ser Thr Gly Ala Lys Thr           
        195                 200                 205                       

tct gcc atc tct caa att acc gat ggt caa atc caa gct acc aag gct        672
Ser Ala Ile Ser Gln Ile Thr Asp Gly Gln Ile Gln Ala Thr Lys Ala           
    210                 215                 220                           

gtt tct gag caa act gaa aac ggt gct gct aag gcc ttt gtt ggt atg        720
Val Ser Glu Gln Thr Glu Asn Gly Ala Ala Lys Ala Phe Val Gly Met           
225                 230                 235                 240           

ggt gct ggt gtt gtc gca gct gcc gct atg ttg tta taa                    759
Gly Ala Gly Val Val Ala Ala Ala Ala Met Leu Leu                           
                245                 250                                   


<210>  15
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Ala Ser Ser Leu Ala Ser Asp Ser Ser Ser 
        35                  40                  45              


Gly Phe Ser Leu Ser Ser Met Pro Ala Gly Val Leu Asp Ile Gly Met 
    50                  55                  60                  


Ala Leu Ala Ser Ala Thr Asp Asp Ser Tyr Thr Thr Leu Tyr Ser Glu 
65                  70                  75                  80  


Val Asp Phe Ala Gly Val Ser Lys Met Leu Thr Met Val Pro Trp Tyr 
                85                  90                  95      


Ser Ser Arg Leu Glu Pro Ala Leu Lys Ser Leu Asn Gly Asp Ala Ser 
            100                 105                 110         


Ser Ser Ala Ala Pro Ser Ser Ser Ala Ala Pro Thr Ser Ser Ala Ala 
        115                 120                 125             


Pro Ser Ser Ser Ala Ala Pro Thr Ser Ser Ala Ala Ser Ser Ser Ser 
    130                 135                 140                 


Glu Ala Lys Ser Ser Ser Ala Ala Pro Ser Ser Ser Glu Ala Lys Ser 
145                 150                 155                 160 


Ser Ser Ala Ala Pro Ser Ser Ser Glu Ala Lys Ser Ser Ser Ala Ala 
                165                 170                 175     


Pro Ser Ser Ser Glu Ala Lys Ser Ser Ser Ala Ala Pro Ser Ser Thr 
            180                 185                 190         


Glu Ala Lys Ile Thr Ser Ala Ala Pro Ser Ser Thr Gly Ala Lys Thr 
        195                 200                 205             


Ser Ala Ile Ser Gln Ile Thr Asp Gly Gln Ile Gln Ala Thr Lys Ala 
    210                 215                 220                 


Val Ser Glu Gln Thr Glu Asn Gly Ala Ala Lys Ala Phe Val Gly Met 
225                 230                 235                 240 


Gly Ala Gly Val Val Ala Ala Ala Ala Met Leu Leu 
                245                 250         


<210>  16
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PST1 tether


<220>
<221>  CDS
<222>  (1)..(1398)

<400>  16
aag gac aat agc tcg acg att gaa ggt aga tac cca tac gac gtt cca         48
Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro           
1               5                   10                  15                

gac tac gct ctg cag gct agt ggt ggt ggt ggt tct ggt ggt ggt ggt         96
Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
            20                  25                  30                    

tct ggt ggt ggt ggt tct gct agc gct act tcc tct tct tcc agc ata        144
Ser Gly Gly Gly Gly Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Ile           
        35                  40                  45                        

ccc tct tcc tgt acc ata agc tca cat gcc acg gcc aca gct cag agt        192
Pro Ser Ser Cys Thr Ile Ser Ser His Ala Thr Ala Thr Ala Gln Ser           
    50                  55                  60                            

gac tta gat aaa tat agc cgc tgt gat acg tta gtc ggg aac tta act        240
Asp Leu Asp Lys Tyr Ser Arg Cys Asp Thr Leu Val Gly Asn Leu Thr           
65                  70                  75                  80            

att ggt ggt ggt ttg aag act ggt gct ttg gct aat gtt aaa gaa atc        288
Ile Gly Gly Gly Leu Lys Thr Gly Ala Leu Ala Asn Val Lys Glu Ile           
                85                  90                  95                

aac ggg tct cta act ata ttt aac gct aca aat cta acc tca ttc gct        336
Asn Gly Ser Leu Thr Ile Phe Asn Ala Thr Asn Leu Thr Ser Phe Ala           
            100                 105                 110                   

gct gat tcc ttg gag tcc atc aca gat tct ttg aac cta cag agt ttg        384
Ala Asp Ser Leu Glu Ser Ile Thr Asp Ser Leu Asn Leu Gln Ser Leu           
        115                 120                 125                       

aca atc ttg act tct gct tca ttt ggg tct tta cag agc gtt gat agt        432
Thr Ile Leu Thr Ser Ala Ser Phe Gly Ser Leu Gln Ser Val Asp Ser           
    130                 135                 140                           

ata aaa ctg att act cta ccc gcc atc tcc agt ttt act tca aat atc        480
Ile Lys Leu Ile Thr Leu Pro Ala Ile Ser Ser Phe Thr Ser Asn Ile           
145                 150                 155                 160           

aaa tct gct aac aac att tat att tcc gac act tcg tta caa tct gtc        528
Lys Ser Ala Asn Asn Ile Tyr Ile Ser Asp Thr Ser Leu Gln Ser Val           
                165                 170                 175               

gat gga ttc tca gcc ttg aaa aaa gtt aac gtg ttc aac gtc aat aac        576
Asp Gly Phe Ser Ala Leu Lys Lys Val Asn Val Phe Asn Val Asn Asn           
            180                 185                 190                   

aat aag aaa tta acc tcg atc aaa tct cca gtt gaa aca gtc agc gat        624
Asn Lys Lys Leu Thr Ser Ile Lys Ser Pro Val Glu Thr Val Ser Asp           
        195                 200                 205                       

tct tta caa ttt tcg ttc aac ggt aac cag act aaa atc acc ttc gat        672
Ser Leu Gln Phe Ser Phe Asn Gly Asn Gln Thr Lys Ile Thr Phe Asp           
    210                 215                 220                           

gac ttg gtt tgg gca aac aat atc agt ttg acc gat gtc cac tct gtt        720
Asp Leu Val Trp Ala Asn Asn Ile Ser Leu Thr Asp Val His Ser Val           
225                 230                 235                 240           

tcc ttc gct aac ttg caa aag att aac tct tca ttg ggt ttc atc aac        768
Ser Phe Ala Asn Leu Gln Lys Ile Asn Ser Ser Leu Gly Phe Ile Asn           
                245                 250                 255               

aac tcc atc tca agt ttg aat ttc act aag cta aac acc att ggc caa        816
Asn Ser Ile Ser Ser Leu Asn Phe Thr Lys Leu Asn Thr Ile Gly Gln           
            260                 265                 270                   

acc ttc agt atc gtt tcc aat gac tac ttg aag aac ttg tcg ttc tct        864
Thr Phe Ser Ile Val Ser Asn Asp Tyr Leu Lys Asn Leu Ser Phe Ser           
        275                 280                 285                       

aat ttg tca acc ata ggt ggt gct ctt gtc gtt gct aac aac act ggt        912
Asn Leu Ser Thr Ile Gly Gly Ala Leu Val Val Ala Asn Asn Thr Gly           
    290                 295                 300                           

tta caa aaa att ggt ggt ctc gac aac cta aca acc att ggc ggt act        960
Leu Gln Lys Ile Gly Gly Leu Asp Asn Leu Thr Thr Ile Gly Gly Thr           
305                 310                 315                 320           

ttg gaa gtt gtt ggt aac ttc acc tcc ttg aac cta gac tct ttg aag       1008
Leu Glu Val Val Gly Asn Phe Thr Ser Leu Asn Leu Asp Ser Leu Lys           
                325                 330                 335               

tct gtc aag ggt ggc gca gat gtc gaa tca aag tca agc aat ttc tcc       1056
Ser Val Lys Gly Gly Ala Asp Val Glu Ser Lys Ser Ser Asn Phe Ser           
            340                 345                 350                   

tgt aat gct ttg aaa gct ttg caa aag aaa ggg ggt atc aag ggt gaa       1104
Cys Asn Ala Leu Lys Ala Leu Gln Lys Lys Gly Gly Ile Lys Gly Glu           
        355                 360                 365                       

tct ttt gtc tgc aaa aat ggt gca tca tcc aca tct gtt aaa cta tcg       1152
Ser Phe Val Cys Lys Asn Gly Ala Ser Ser Thr Ser Val Lys Leu Ser           
    370                 375                 380                           

tcc act tcc aaa tct caa tca agc caa act act gcc aag gtt tcc aag       1200
Ser Thr Ser Lys Ser Gln Ser Ser Gln Thr Thr Ala Lys Val Ser Lys           
385                 390                 395                 400           

tca tct tct aag gcc gag gaa aag aag ttc act tct ggc gat atc aag       1248
Ser Ser Ser Lys Ala Glu Glu Lys Lys Phe Thr Ser Gly Asp Ile Lys           
                405                 410                 415               

gct gct gct tct gcc tct agt gtt tct agt tct ggc gct tcc agc tct       1296
Ala Ala Ala Ser Ala Ser Ser Val Ser Ser Ser Gly Ala Ser Ser Ser           
            420                 425                 430                   

agc tct aag agt tcc aaa ggc aat gcc gct atc atg gca cca att ggc       1344
Ser Ser Lys Ser Ser Lys Gly Asn Ala Ala Ile Met Ala Pro Ile Gly           
        435                 440                 445                       

caa aca acc cct ttg gtc ggt ctt ttg acg gca atc atc atg tct ata       1392
Gln Thr Thr Pro Leu Val Gly Leu Leu Thr Ala Ile Ile Met Ser Ile           
    450                 455                 460                           

atg taa                                                               1398
Met                                                                       
465                                                                       


<210>  17
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Ile 
        35                  40                  45              


Pro Ser Ser Cys Thr Ile Ser Ser His Ala Thr Ala Thr Ala Gln Ser 
    50                  55                  60                  


Asp Leu Asp Lys Tyr Ser Arg Cys Asp Thr Leu Val Gly Asn Leu Thr 
65                  70                  75                  80  


Ile Gly Gly Gly Leu Lys Thr Gly Ala Leu Ala Asn Val Lys Glu Ile 
                85                  90                  95      


Asn Gly Ser Leu Thr Ile Phe Asn Ala Thr Asn Leu Thr Ser Phe Ala 
            100                 105                 110         


Ala Asp Ser Leu Glu Ser Ile Thr Asp Ser Leu Asn Leu Gln Ser Leu 
        115                 120                 125             


Thr Ile Leu Thr Ser Ala Ser Phe Gly Ser Leu Gln Ser Val Asp Ser 
    130                 135                 140                 


Ile Lys Leu Ile Thr Leu Pro Ala Ile Ser Ser Phe Thr Ser Asn Ile 
145                 150                 155                 160 


Lys Ser Ala Asn Asn Ile Tyr Ile Ser Asp Thr Ser Leu Gln Ser Val 
                165                 170                 175     


Asp Gly Phe Ser Ala Leu Lys Lys Val Asn Val Phe Asn Val Asn Asn 
            180                 185                 190         


Asn Lys Lys Leu Thr Ser Ile Lys Ser Pro Val Glu Thr Val Ser Asp 
        195                 200                 205             


Ser Leu Gln Phe Ser Phe Asn Gly Asn Gln Thr Lys Ile Thr Phe Asp 
    210                 215                 220                 


Asp Leu Val Trp Ala Asn Asn Ile Ser Leu Thr Asp Val His Ser Val 
225                 230                 235                 240 


Ser Phe Ala Asn Leu Gln Lys Ile Asn Ser Ser Leu Gly Phe Ile Asn 
                245                 250                 255     


Asn Ser Ile Ser Ser Leu Asn Phe Thr Lys Leu Asn Thr Ile Gly Gln 
            260                 265                 270         


Thr Phe Ser Ile Val Ser Asn Asp Tyr Leu Lys Asn Leu Ser Phe Ser 
        275                 280                 285             


Asn Leu Ser Thr Ile Gly Gly Ala Leu Val Val Ala Asn Asn Thr Gly 
    290                 295                 300                 


Leu Gln Lys Ile Gly Gly Leu Asp Asn Leu Thr Thr Ile Gly Gly Thr 
305                 310                 315                 320 


Leu Glu Val Val Gly Asn Phe Thr Ser Leu Asn Leu Asp Ser Leu Lys 
                325                 330                 335     


Ser Val Lys Gly Gly Ala Asp Val Glu Ser Lys Ser Ser Asn Phe Ser 
            340                 345                 350         


Cys Asn Ala Leu Lys Ala Leu Gln Lys Lys Gly Gly Ile Lys Gly Glu 
        355                 360                 365             


Ser Phe Val Cys Lys Asn Gly Ala Ser Ser Thr Ser Val Lys Leu Ser 
    370                 375                 380                 


Ser Thr Ser Lys Ser Gln Ser Ser Gln Thr Thr Ala Lys Val Ser Lys 
385                 390                 395                 400 


Ser Ser Ser Lys Ala Glu Glu Lys Lys Phe Thr Ser Gly Asp Ile Lys 
                405                 410                 415     


Ala Ala Ala Ser Ala Ser Ser Val Ser Ser Ser Gly Ala Ser Ser Ser 
            420                 425                 430         


Ser Ser Lys Ser Ser Lys Gly Asn Ala Ala Ile Met Ala Pro Ile Gly 
        435                 440                 445             


Gln Thr Thr Pro Leu Val Gly Leu Leu Thr Ala Ile Ile Met Ser Ile 
    450                 455                 460                 


Met 
465 


<210>  18
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aga1/2 tether


<220>
<221>  CDS
<222>  (1)..(330)

<400>  18
aag gac aat agc tcg acg att gaa ggt aga tac cca tac gac gtt cca         48
Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro           
1               5                   10                  15                

gac tac gct ctg cag gct agt ggt ggt ggt ggt tct ggt ggt ggt ggt         96
Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
            20                  25                  30                    

tct ggt ggt ggt ggt tct gct agc cag gaa ctg aca act ata tgc gag        144
Ser Gly Gly Gly Gly Ser Ala Ser Gln Glu Leu Thr Thr Ile Cys Glu           
        35                  40                  45                        

caa atc ccc tca cca act tta gaa tcg acg ccg tac tct ttg tca acg        192
Gln Ile Pro Ser Pro Thr Leu Glu Ser Thr Pro Tyr Ser Leu Ser Thr           
    50                  55                  60                            

act act att ttg gcc aac ggg aag gca atg caa gga gtt ttt gaa tat        240
Thr Thr Ile Leu Ala Asn Gly Lys Ala Met Gln Gly Val Phe Glu Tyr           
65                  70                  75                  80            

tac aaa tca gta acg ttt gtc agt aat tgc ggt tct cac ccc tca aca        288
Tyr Lys Ser Val Thr Phe Val Ser Asn Cys Gly Ser His Pro Ser Thr           
                85                  90                  95                

act agc aaa ggc agc ccc ata aac aca cag tat gtt ttt taa                330
Thr Ser Lys Gly Ser Pro Ile Asn Thr Gln Tyr Val Phe                       
            100                 105                                       


<210>  19
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Ala Ser Gln Glu Leu Thr Thr Ile Cys Glu 
        35                  40                  45              


Gln Ile Pro Ser Pro Thr Leu Glu Ser Thr Pro Tyr Ser Leu Ser Thr 
    50                  55                  60                  


Thr Thr Ile Leu Ala Asn Gly Lys Ala Met Gln Gly Val Phe Glu Tyr 
65                  70                  75                  80  


Tyr Lys Ser Val Thr Phe Val Ser Asn Cys Gly Ser His Pro Ser Thr 
                85                  90                  95      


Thr Ser Lys Gly Ser Pro Ile Asn Thr Gln Tyr Val Phe 
            100                 105                 


<210>  20
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aga1/2 tether


<220>
<221>  CDS
<222>  (1)..(381)

<400>  20
atg cag tta ctt cgc tgt ttt tca ata ttt tct gtt att gct tca gtt         48
Met Gln Leu Leu Arg Cys Phe Ser Ile Phe Ser Val Ile Ala Ser Val           
1               5                   10                  15                

tta gca cag gag ctg aca act ata tgc gag caa atc ccc tca cca act         96
Leu Ala Gln Glu Leu Thr Thr Ile Cys Glu Gln Ile Pro Ser Pro Thr           
            20                  25                  30                    

tta gaa tcg acg ccg tac tct ttg tca acg act act att ttg gcc aac        144
Leu Glu Ser Thr Pro Tyr Ser Leu Ser Thr Thr Thr Ile Leu Ala Asn           
        35                  40                  45                        

ggg aag gca atg caa gga gtt ttt gaa tat tac aaa tca gta acg ttt        192
Gly Lys Ala Met Gln Gly Val Phe Glu Tyr Tyr Lys Ser Val Thr Phe           
    50                  55                  60                            

gtc agt aat tgc gat tct cac ccc tca aca act agc aaa gac agc ccc        240
Val Ser Asn Cys Asp Ser His Pro Ser Thr Thr Ser Lys Asp Ser Pro           
65                  70                  75                  80            

ata aac aca cag tat gtt ttt aag gac aat agc tcg acg att gaa ggt        288
Ile Asn Thr Gln Tyr Val Phe Lys Asp Asn Ser Ser Thr Ile Glu Gly           
                85                  90                  95                

aga tac cca tac gac gtt cca gac tac gct ctg cag gct agt ggt ggt        336
Arg Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Leu Gln Ala Ser Gly Gly           
            100                 105                 110                   

ggt ggt tct ggt ggt ggt ggt tct ggt ggt ggt ggt tct gct agc            381
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser               
        115                 120                 125                       


<210>  21
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Gln Leu Leu Arg Cys Phe Ser Ile Phe Ser Val Ile Ala Ser Val 
1               5                   10                  15      


Leu Ala Gln Glu Leu Thr Thr Ile Cys Glu Gln Ile Pro Ser Pro Thr 
            20                  25                  30          


Leu Glu Ser Thr Pro Tyr Ser Leu Ser Thr Thr Thr Ile Leu Ala Asn 
        35                  40                  45              


Gly Lys Ala Met Gln Gly Val Phe Glu Tyr Tyr Lys Ser Val Thr Phe 
    50                  55                  60                  


Val Ser Asn Cys Asp Ser His Pro Ser Thr Thr Ser Lys Asp Ser Pro 
65                  70                  75                  80  


Ile Asn Thr Gln Tyr Val Phe Lys Asp Asn Ser Ser Thr Ile Glu Gly 
                85                  90                  95      


Arg Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Leu Gln Ala Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser 
        115                 120                 125         


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  22

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  23

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  24
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  24

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  25

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  26

Glu Ala Ala Lys Glu Ala Ala Lys Glu Ala Ala Lys 
1               5                   10          


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  27

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  28
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  28

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  29
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPI1 tether

<400>  29
gctgctaacg caagagcaat cccaggagcc ctaggtttgg ctggtgcagt tatgatgctt       60

ttatga                                                                  66


<210>  30
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Ala Ala Asn Ala Arg Ala Ile Pro Gly Ala Leu Gly Leu Ala Gly Ala 
1               5                   10                  15      


Val Met Met Leu Leu 
            20      


<210>  31
<211>  156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPI tether

<400>  31
ttaacaatta ccaactgtcc ttgcactatc gagaagccta cttcagaaac atcggtttct       60

tctacacatg atgtggagac aaattctaat gctgctaacg caagagcaat cccaggagcc      120

ctaggtttgg ctggtgcagt tatgatgctt ttatga                                156


<210>  32
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Leu Thr Ile Thr Asn Cys Pro Cys Thr Ile Glu Lys Pro Thr Ser Glu 
1               5                   10                  15      


Thr Ser Val Ser Ser Thr His Asp Val Glu Thr Asn Ser Asn Ala Ala 
            20                  25                  30          


Asn Ala Arg Ala Ile Pro Gly Ala Leu Gly Leu Ala Gly Ala Val Met 
        35                  40                  45              


Met Leu Leu 
    50      


<210>  33
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPI1 tether

<400>  33
gaagttgtca gtgaattcac tacttactgc ccagaaccaa cgactttcgt aacgaatggc       60

gctacattca ctgttactgc cccaactacg ttaacaatta ccaactgtcc ttgcactatc      120

gagaagccta cttcagaaac atcggtttct tctacacatg atgtggagac aaattctaat      180

gctgctaacg caagagcaat cccaggagcc ctaggtttgg ctggtgcagt tatgatgctt      240

ttatga                                                                 246


<210>  34
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Glu Val Val Ser Glu Phe Thr Thr Tyr Cys Pro Glu Pro Thr Thr Phe 
1               5                   10                  15      


Val Thr Asn Gly Ala Thr Phe Thr Val Thr Ala Pro Thr Thr Leu Thr 
            20                  25                  30          


Ile Thr Asn Cys Pro Cys Thr Ile Glu Lys Pro Thr Ser Glu Thr Ser 
        35                  40                  45              


Val Ser Ser Thr His Asp Val Glu Thr Asn Ser Asn Ala Ala Asn Ala 
    50                  55                  60                  


Arg Ala Ile Pro Gly Ala Leu Gly Leu Ala Gly Ala Val Met Met Leu 
65                  70                  75                  80  


Leu 
    


<210>  35
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPI1 tether

<400>  35
attgccggta acgatacagc cacgccagca ccagagccat catccgccgc tccaatattc       60

tacaactcga ctgctactgc aacacagtac gaagttgtca gtgaattcac tacttactgc      120

ccagaaccaa cgactttcgt aacgaatggc gctacattca ctgttactgc cccaactacg      180

ttaacaatta ccaactgtcc ttgcactatc gagaagccta cttcagaaac atcggtttct      240

tctacacatg atgtggagac aaattctaat gctgctaacg caagagcaat cccaggagcc      300

ctaggtttgg ctggtgcagt tatgatgctt ttatga                                336


<210>  36
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Ile Ala Gly Asn Asp Thr Ala Thr Pro Ala Pro Glu Pro Ser Ser Ala 
1               5                   10                  15      


Ala Pro Ile Phe Tyr Asn Ser Thr Ala Thr Ala Thr Gln Tyr Glu Val 
            20                  25                  30          


Val Ser Glu Phe Thr Thr Tyr Cys Pro Glu Pro Thr Thr Phe Val Thr 
        35                  40                  45              


Asn Gly Ala Thr Phe Thr Val Thr Ala Pro Thr Thr Leu Thr Ile Thr 
    50                  55                  60                  


Asn Cys Pro Cys Thr Ile Glu Lys Pro Thr Ser Glu Thr Ser Val Ser 
65                  70                  75                  80  


Ser Thr His Asp Val Glu Thr Asn Ser Asn Ala Ala Asn Ala Arg Ala 
                85                  90                  95      


Ile Pro Gly Ala Leu Gly Leu Ala Gly Ala Val Met Met Leu Leu 
            100                 105                 110     


<210>  37
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCW12 tether

<400>  37
tacactggtg ctgctgctaa ggctttgcca gctgctggtg ctttgttggc tggtgccgct       60

gctttgttgt tgtaa                                                        75


<210>  38
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Tyr Thr Gly Ala Ala Ala Lys Ala Leu Pro Ala Ala Gly Ala Leu Leu 
1               5                   10                  15      


Ala Gly Ala Ala Ala Leu Leu Leu 
            20                  


<210>  39
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCW12 tether

<400>  39
actgctgctc cagttacctc tactgaagct ccaaagaaca ccacctctgc tgctccaact       60

cactctgtca cctcttacac tggtgctgct gctaaggctt tgccagctgc tggtgctttg      120

ttggctggtg ccgctgcttt gttgttgtaa                                       150


<210>  40
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40

Thr Ala Ala Pro Val Thr Ser Thr Glu Ala Pro Lys Asn Thr Thr Ser 
1               5                   10                  15      


Ala Ala Pro Thr His Ser Val Thr Ser Tyr Thr Gly Ala Ala Ala Lys 
            20                  25                  30          


Ala Leu Pro Ala Ala Gly Ala Leu Leu Ala Gly Ala Ala Ala Leu Leu 
        35                  40                  45              


Leu 
    


<210>  41
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCW12 tether

<400>  41
accgtcgatg acgttatcac tcaatacacc acctggtgcc cattgaccac tgaagcccca       60

aagaacggta cttctactgc tgctccagtt acctctactg aagctccaaa gaacaccacc      120

tctgctgctc caactcactc tgtcacctct tacactggtg ctgctgctaa ggctttgcca      180

gctgctggtg ctttgttggc tggtgccgct gctttgttgt tgtaa                      225


<210>  42
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Thr Val Asp Asp Val Ile Thr Gln Tyr Thr Thr Trp Cys Pro Leu Thr 
1               5                   10                  15      


Thr Glu Ala Pro Lys Asn Gly Thr Ser Thr Ala Ala Pro Val Thr Ser 
            20                  25                  30          


Thr Glu Ala Pro Lys Asn Thr Thr Ser Ala Ala Pro Thr His Ser Val 
        35                  40                  45              


Thr Ser Tyr Thr Gly Ala Ala Ala Lys Ala Leu Pro Ala Ala Gly Ala 
    50                  55                  60                  


Leu Leu Ala Gly Ala Ala Ala Leu Leu Leu 
65                  70                  


<210>  43
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCW12 tether

<400>  43
gtcaccatca cttcttgtga agaccacgtc tgttctgaaa ctgtctcccc agctttggtt       60

tccaccgcta ccgtcaccgt cgatgacgtt atcactcaat acaccacctg gtgcccattg      120

accactgaag ccccaaagaa cggtacttct actgctgctc cagttacctc tactgaagct      180

ccaaagaaca ccacctctgc tgctccaact cactctgtca cctcttacac tggtgctgct      240

gctaaggctt tgccagctgc tggtgctttg ttggctggtg ccgctgcttt gttgttgtaa      300


<210>  44
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44

Val Thr Ile Thr Ser Cys Glu Asp His Val Cys Ser Glu Thr Val Ser 
1               5                   10                  15      


Pro Ala Leu Val Ser Thr Ala Thr Val Thr Val Asp Asp Val Ile Thr 
            20                  25                  30          


Gln Tyr Thr Thr Trp Cys Pro Leu Thr Thr Glu Ala Pro Lys Asn Gly 
        35                  40                  45              


Thr Ser Thr Ala Ala Pro Val Thr Ser Thr Glu Ala Pro Lys Asn Thr 
    50                  55                  60                  


Thr Ser Ala Ala Pro Thr His Ser Val Thr Ser Tyr Thr Gly Ala Ala 
65                  70                  75                  80  


Ala Lys Ala Leu Pro Ala Ala Gly Ala Leu Leu Ala Gly Ala Ala Ala 
                85                  90                  95      


Leu Leu Leu 
            


<210>  45
<211>  499
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter of TEF2 gene

<400>  45
gggcgccata accaaggtat ctatagaccg ccaatcagca aactacctcc gtacattcct       60

gttgcaccca cacatttata cacccagacc gcgacaaatt acccataagg ttgtttgtga      120

cggcgtcgta caagagaacg tgggaacttt ttaggctcac caaaaaagaa aggaaaaata      180

cgagttgctg acagaagcct caagaaaaaa aaaattcttc ttcgactatg ctggagccag      240

agatgatcga gccggtagtt aactatatat agctaaattg gttccatcac cttcttttct      300

ggtgtcgctc cttctagtgc tatttctggc ttttcctatt tttttttttc catttttctt      360

tctctctttc taatatataa attctcttgc attttctatt tttctctcta tctattctac      420

ttgtttattc ccttcaaggt tttttttaag gactacttgt ttttagaata tacggtcaac      480

gaactataat taactaaac                                                   499


<210>  46
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADH3 terminator

<400>  46
tagcgtgtta cgcacccaaa ctttttatga aagtctttgt ttataatgat gaggtttata       60

aatatatagt ggagcaaaga ttaatcacta aatcaagaag cagtaccagt atttttttta      120

tatcaagtag tgataatgga aatagcccaa atttggcttc cgtcggcaca tagcacgttt      180

gagagacatt atcaccatca agcatcgagc cgcccaaacc taactgtata agttttttca      240

cgtttttgat ttttccttgc acacttcgat attactctca cgataaaagg gccgaagaga      300

atatttttct tgaacatcca gaattttaat tcggagaaat ttcacaagcc gccgatttaa      360

gggtcctgtg ttcttaataa tcagcctctc tcaaagcagg taagaggcag tctttctttt      420

aacaatagga gacattcgaa ctaaaacatc agccccaaaa atgcgcttga aggtcattag      480

gatttggatt tcttcctcat                                                  500


<210>  47
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Terminator of IDP1 gene

<400>  47
tcgaatttac gtagcccaat ctaccacttt ttttttcatt ttttaaagtg ttatacttag       60

ttatgctcta ggataatgaa ctactttttt ttttttttac tgttatcata aatatatata      120

ccttattgat gtttgcaacc gtcggttaat tccttatcaa ggttccccaa gttcggatca      180

ttaccatcaa tttccaacat cttcatgagt tcttcttctt cattaccgtg ttttaggggg      240

ctgttcgcac ttctaatagg gctatcacca agctgttcta attcgtccaa aagttcagta      300

acacgatctt tatgcttcag ttcgtcataa tctttcaatt cataaatatt tacaatttcg      360

tctacgatat taaattgcct cttgtaggtg cctatctttt ccttatgctc ttcattttca      420

ccgttttctt gaaaccaaac accgaactca ctacgcattt ctttcatagg ctcatataat      480

acttcttttg acgtcatttg                                                  500


<210>  48
<211>  19
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  48

Met Leu Leu Gln Ala Phe Leu Phe Leu Leu Ala Gly Phe Ala Ala Lys 
1               5                   10                  15      


Ile Ser Ala 
            


<210>  49
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA Tag

<400>  49

Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Leu Gln Ala 
            20          


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  50

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence from AGA2

<400>  51

Met Gln Leu Leu Arg Cys Phe Ser Ile Phe Ser Val Ile Ala Ser Val 
1               5                   10                  15      


Leu Ala 
        


<210>  52
<211>  1641
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLO1 tether


<220>
<221>  CDS
<222>  (1)..(1641)

<400>  52
aag gac aat agc tcg acg att gaa ggt aga tac cca tac gac gtt cca         48
Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro           
1               5                   10                  15                

gac tac gct ctg cag gct agt ggt ggt ggt ggt tct ggt ggt ggt ggt         96
Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
            20                  25                  30                    

tct ggt ggt ggt ggt tct gct agc atc aga act cca acc agt gaa ggt        144
Ser Gly Gly Gly Gly Ser Ala Ser Ile Arg Thr Pro Thr Ser Glu Gly           
        35                  40                  45                        

ttg gtt aca acc acc act gaa cca tgg act ggt act ttt act tcg act        192
Leu Val Thr Thr Thr Thr Glu Pro Trp Thr Gly Thr Phe Thr Ser Thr           
    50                  55                  60                            

tcc act gaa atg tct act gtc act gga acc aat ggc ttg cca act gat        240
Ser Thr Glu Met Ser Thr Val Thr Gly Thr Asn Gly Leu Pro Thr Asp           
65                  70                  75                  80            

gaa act gtc att gtt gtc aaa act cca act act gcc atc tca tcc agt        288
Glu Thr Val Ile Val Val Lys Thr Pro Thr Thr Ala Ile Ser Ser Ser           
                85                  90                  95                

ttg tca tca tca tct tca gga caa atc acc agc tct atc acg tct tcg        336
Leu Ser Ser Ser Ser Ser Gly Gln Ile Thr Ser Ser Ile Thr Ser Ser           
            100                 105                 110                   

cgt cca att att acc cca ttc tat cct agc aat gga act tct gtg att        384
Arg Pro Ile Ile Thr Pro Phe Tyr Pro Ser Asn Gly Thr Ser Val Ile           
        115                 120                 125                       

tct tcc tca gta att tct tcc tca gtc act tct tct cta ttc act tct        432
Ser Ser Ser Val Ile Ser Ser Ser Val Thr Ser Ser Leu Phe Thr Ser           
    130                 135                 140                           

tct cca gtc att tct tcc tca gtc att tct tct tct aca aca acc tcc        480
Ser Pro Val Ile Ser Ser Ser Val Ile Ser Ser Ser Thr Thr Thr Ser           
145                 150                 155                 160           

act tct ata ttt tct gaa tca tct aaa tca tcc gtc att cca acc agt        528
Thr Ser Ile Phe Ser Glu Ser Ser Lys Ser Ser Val Ile Pro Thr Ser           
                165                 170                 175               

agt tcc acc tct ggt tct tct gag agc gaa acg agt tca gct ggt tct        576
Ser Ser Thr Ser Gly Ser Ser Glu Ser Glu Thr Ser Ser Ala Gly Ser           
            180                 185                 190                   

gtc tct tct tcc tct ttt atc tct tct gaa tca tca aaa tct cct aca        624
Val Ser Ser Ser Ser Phe Ile Ser Ser Glu Ser Ser Lys Ser Pro Thr           
        195                 200                 205                       

tat tct tct tca tca tta cca ctt gtt acc agt gcg aca aca agc cag        672
Tyr Ser Ser Ser Ser Leu Pro Leu Val Thr Ser Ala Thr Thr Ser Gln           
    210                 215                 220                           

gaa act gct tct tca tta cca cct gct acc act aca aaa acg agc gaa        720
Glu Thr Ala Ser Ser Leu Pro Pro Ala Thr Thr Thr Lys Thr Ser Glu           
225                 230                 235                 240           

caa acc act ttg gtt acc gtg aca tcc tgc gag tct cat gtg tgc act        768
Gln Thr Thr Leu Val Thr Val Thr Ser Cys Glu Ser His Val Cys Thr           
                245                 250                 255               

gaa tcc atc tcc cct gcg att gtt tcc aca gct act gtt act gtt agc        816
Glu Ser Ile Ser Pro Ala Ile Val Ser Thr Ala Thr Val Thr Val Ser           
            260                 265                 270                   

ggc gtc aca aca gag tat acc aca tgg tgc cct att tct act aca gag        864
Gly Val Thr Thr Glu Tyr Thr Thr Trp Cys Pro Ile Ser Thr Thr Glu           
        275                 280                 285                       

aca aca aag caa acc aaa ggg aca aca gag caa acc aca gaa aca aca        912
Thr Thr Lys Gln Thr Lys Gly Thr Thr Glu Gln Thr Thr Glu Thr Thr           
    290                 295                 300                           

aaa caa acc acg gta gtt aca att tct tct tgt gaa tct gac gta tgc        960
Lys Gln Thr Thr Val Val Thr Ile Ser Ser Cys Glu Ser Asp Val Cys           
305                 310                 315                 320           

tct aag act gct tct cca gcc att gta tct aca agc act gct act att       1008
Ser Lys Thr Ala Ser Pro Ala Ile Val Ser Thr Ser Thr Ala Thr Ile           
                325                 330                 335               

aac ggc gtt act aca gaa tac aca aca tgg tgt cct att tcc acc aca       1056
Asn Gly Val Thr Thr Glu Tyr Thr Thr Trp Cys Pro Ile Ser Thr Thr           
            340                 345                 350                   

gaa tcg agg caa caa aca acg cta gtt act gtt act tcc tgc gaa tct       1104
Glu Ser Arg Gln Gln Thr Thr Leu Val Thr Val Thr Ser Cys Glu Ser           
        355                 360                 365                       

ggt gtg tgt tcc gaa act gct tca cct gcc att gtt tcg acg gcc acg       1152
Gly Val Cys Ser Glu Thr Ala Ser Pro Ala Ile Val Ser Thr Ala Thr           
    370                 375                 380                           

gct act gtg aat gat gtt gtt acg gtc tat cct aca tgg agg cca cag       1200
Ala Thr Val Asn Asp Val Val Thr Val Tyr Pro Thr Trp Arg Pro Gln           
385                 390                 395                 400           

act gcg aat gaa gag tct gtc agc tct aaa atg aac agt gct acc ggt       1248
Thr Ala Asn Glu Glu Ser Val Ser Ser Lys Met Asn Ser Ala Thr Gly           
                405                 410                 415               

gag aca aca acc aat act tta gct gct gaa acg act acc aat act gta       1296
Glu Thr Thr Thr Asn Thr Leu Ala Ala Glu Thr Thr Thr Asn Thr Val           
            420                 425                 430                   

gct gct gag acg att acc aat act gga gct gct gag acg aaa aca gta       1344
Ala Ala Glu Thr Ile Thr Asn Thr Gly Ala Ala Glu Thr Lys Thr Val           
        435                 440                 445                       

gtc acc tct tcg ctt tca aga tct aat cac gct gaa aca cag acg gct       1392
Val Thr Ser Ser Leu Ser Arg Ser Asn His Ala Glu Thr Gln Thr Ala           
    450                 455                 460                           

tcc gcg acc gat gtg att ggt cac agc agt agt gtt gtt tct gta tcc       1440
Ser Ala Thr Asp Val Ile Gly His Ser Ser Ser Val Val Ser Val Ser           
465                 470                 475                 480           

gaa act ggc aac acc aag agt cta aca agt tcc ggg ttg agt act atg       1488
Glu Thr Gly Asn Thr Lys Ser Leu Thr Ser Ser Gly Leu Ser Thr Met           
                485                 490                 495               

tcg caa cag cct cgt agc aca cca gca agc agc atg gta gga tat agt       1536
Ser Gln Gln Pro Arg Ser Thr Pro Ala Ser Ser Met Val Gly Tyr Ser           
            500                 505                 510                   

aca gct tct tta gaa att tca acg tat gct ggc agt gcc aac agc tta       1584
Thr Ala Ser Leu Glu Ile Ser Thr Tyr Ala Gly Ser Ala Asn Ser Leu           
        515                 520                 525                       

ctg gcc ggt agt ggt tta agt gtc ttc att gcg tcc tta ttg ctg gca       1632
Leu Ala Gly Ser Gly Leu Ser Val Phe Ile Ala Ser Leu Leu Leu Ala           
    530                 535                 540                           

att att taa                                                           1641
Ile Ile                                                                   
545                                                                       


<210>  53
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Lys Asp Asn Ser Ser Thr Ile Glu Gly Arg Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Leu Gln Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Ala Ser Ile Arg Thr Pro Thr Ser Glu Gly 
        35                  40                  45              


Leu Val Thr Thr Thr Thr Glu Pro Trp Thr Gly Thr Phe Thr Ser Thr 
    50                  55                  60                  


Ser Thr Glu Met Ser Thr Val Thr Gly Thr Asn Gly Leu Pro Thr Asp 
65                  70                  75                  80  


Glu Thr Val Ile Val Val Lys Thr Pro Thr Thr Ala Ile Ser Ser Ser 
                85                  90                  95      


Leu Ser Ser Ser Ser Ser Gly Gln Ile Thr Ser Ser Ile Thr Ser Ser 
            100                 105                 110         


Arg Pro Ile Ile Thr Pro Phe Tyr Pro Ser Asn Gly Thr Ser Val Ile 
        115                 120                 125             


Ser Ser Ser Val Ile Ser Ser Ser Val Thr Ser Ser Leu Phe Thr Ser 
    130                 135                 140                 


Ser Pro Val Ile Ser Ser Ser Val Ile Ser Ser Ser Thr Thr Thr Ser 
145                 150                 155                 160 


Thr Ser Ile Phe Ser Glu Ser Ser Lys Ser Ser Val Ile Pro Thr Ser 
                165                 170                 175     


Ser Ser Thr Ser Gly Ser Ser Glu Ser Glu Thr Ser Ser Ala Gly Ser 
            180                 185                 190         


Val Ser Ser Ser Ser Phe Ile Ser Ser Glu Ser Ser Lys Ser Pro Thr 
        195                 200                 205             


Tyr Ser Ser Ser Ser Leu Pro Leu Val Thr Ser Ala Thr Thr Ser Gln 
    210                 215                 220                 


Glu Thr Ala Ser Ser Leu Pro Pro Ala Thr Thr Thr Lys Thr Ser Glu 
225                 230                 235                 240 


Gln Thr Thr Leu Val Thr Val Thr Ser Cys Glu Ser His Val Cys Thr 
                245                 250                 255     


Glu Ser Ile Ser Pro Ala Ile Val Ser Thr Ala Thr Val Thr Val Ser 
            260                 265                 270         


Gly Val Thr Thr Glu Tyr Thr Thr Trp Cys Pro Ile Ser Thr Thr Glu 
        275                 280                 285             


Thr Thr Lys Gln Thr Lys Gly Thr Thr Glu Gln Thr Thr Glu Thr Thr 
    290                 295                 300                 


Lys Gln Thr Thr Val Val Thr Ile Ser Ser Cys Glu Ser Asp Val Cys 
305                 310                 315                 320 


Ser Lys Thr Ala Ser Pro Ala Ile Val Ser Thr Ser Thr Ala Thr Ile 
                325                 330                 335     


Asn Gly Val Thr Thr Glu Tyr Thr Thr Trp Cys Pro Ile Ser Thr Thr 
            340                 345                 350         


Glu Ser Arg Gln Gln Thr Thr Leu Val Thr Val Thr Ser Cys Glu Ser 
        355                 360                 365             


Gly Val Cys Ser Glu Thr Ala Ser Pro Ala Ile Val Ser Thr Ala Thr 
    370                 375                 380                 


Ala Thr Val Asn Asp Val Val Thr Val Tyr Pro Thr Trp Arg Pro Gln 
385                 390                 395                 400 


Thr Ala Asn Glu Glu Ser Val Ser Ser Lys Met Asn Ser Ala Thr Gly 
                405                 410                 415     


Glu Thr Thr Thr Asn Thr Leu Ala Ala Glu Thr Thr Thr Asn Thr Val 
            420                 425                 430         


Ala Ala Glu Thr Ile Thr Asn Thr Gly Ala Ala Glu Thr Lys Thr Val 
        435                 440                 445             


Val Thr Ser Ser Leu Ser Arg Ser Asn His Ala Glu Thr Gln Thr Ala 
    450                 455                 460                 


Ser Ala Thr Asp Val Ile Gly His Ser Ser Ser Val Val Ser Val Ser 
465                 470                 475                 480 


Glu Thr Gly Asn Thr Lys Ser Leu Thr Ser Ser Gly Leu Ser Thr Met 
                485                 490                 495     


Ser Gln Gln Pro Arg Ser Thr Pro Ala Ser Ser Met Val Gly Tyr Ser 
            500                 505                 510         


Thr Ala Ser Leu Glu Ile Ser Thr Tyr Ala Gly Ser Ala Asn Ser Leu 
        515                 520                 525             


Leu Ala Gly Ser Gly Leu Ser Val Phe Ile Ala Ser Leu Leu Leu Ala 
    530                 535                 540                 


Ile Ile 
545     


<210>  54
<211>  435
<212>  PRT
<213>  Thermococcus gammatolerans

<400>  54

Lys Tyr Ser Glu Leu Glu Gln Gly Gly Val Ile Met Gln Ala Phe Tyr 
1               5                   10                  15      


Trp Asp Val Pro Ala Gly Gly Ile Trp Trp Asp Thr Ile Arg Gln Lys 
            20                  25                  30          


Ile Pro Glu Trp Tyr Asp Ala Gly Ile Ser Ala Ile Trp Ile Pro Pro 
        35                  40                  45              


Ala Ser Lys Gly Met Gly Gly Ala Tyr Ser Met Gly Tyr Asp Pro Tyr 
    50                  55                  60                  


Asp Tyr Phe Asp Leu Gly Glu Phe Tyr Gln Lys Gly Thr Val Glu Thr 
65                  70                  75                  80  


Arg Phe Gly Ser Lys Glu Glu Leu Val Asn Met Ile Ser Thr Ala His 
                85                  90                  95      


Arg Tyr Gly Ile Lys Val Ile Ala Asp Ile Val Ile Asn His Arg Ala 
            100                 105                 110         


Gly Gly Asp Leu Glu Trp Asn Pro Tyr Val Gly Asp Tyr Thr Trp Thr 
        115                 120                 125             


Asp Phe Ser Gln Val Ala Ser Gly Lys Tyr Lys Ala His Tyr Met Asp 
    130                 135                 140                 


Phe His Pro Asn Asn Tyr Ser Thr Ser Asp Glu Gly Thr Phe Gly Gly 
145                 150                 155                 160 


Phe Pro Asp Ile Asp His Leu Val Pro Phe Asn Lys Tyr Trp Leu Trp 
                165                 170                 175     


Ala Ser Asp Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Val Asp 
            180                 185                 190         


Ala Trp Arg Phe Asp Tyr Val Lys Gly Tyr Gly Ala Trp Val Val Lys 
        195                 200                 205             


Asp Trp Leu Ser Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp 
    210                 215                 220                 


Thr Asp Val Asn Ala Leu Leu Asn Trp Ala Tyr Asp Ser Gly Ala Lys 
225                 230                 235                 240 


Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn 
                245                 250                 255     


Lys Asn Ile Pro Ala Leu Val Tyr Ala Ile Gln Asn Gly Gly Thr Val 
            260                 265                 270         


Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His Asp 
        275                 280                 285             


Thr Asn Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr 
    290                 295                 300                 


Tyr Glu Gly Gln Pro Val Ile Phe Tyr Arg Asp Tyr Glu Glu Trp Leu 
305                 310                 315                 320 


Asn Lys Asp Lys Leu Asn Asn Leu Ile Trp Ile His Glu His Leu Ala 
                325                 330                 335     


Gly Gly Ser Thr Lys Ile Leu Tyr Tyr Asp Asp Asp Glu Leu Ile Phe 
            340                 345                 350         


Met Arg Glu Gly Tyr Gly Asp Arg Pro Gly Leu Ile Thr Tyr Ile Asn 
        355                 360                 365             


Leu Gly Ser Gly Trp Ala Glu Arg Trp Val Asn Val Gly Ser Lys Phe 
    370                 375                 380                 


Ala Gly Tyr Thr Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Val 
385                 390                 395                 400 


Asp Arg Tyr Val Tyr Tyr Asn Gly Trp Val Lys Leu Thr Ala Pro Pro 
                405                 410                 415     


His Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr Ala 
            420                 425                 430         


Gly Val Gly 
        435 


<210>  55
<211>  432
<212>  PRT
<213>  Thermococcus thioreducens

<400>  55

Glu Thr Leu Glu Asn Gly Gly Val Ile Met Gln Ala Phe Tyr Trp Asp 
1               5                   10                  15      


Val Pro Met Gly Gly Ile Trp Trp Asp Thr Ile Ala Gln Lys Ile Pro 
            20                  25                  30          


Asp Trp Ala Ser Ala Gly Ile Ser Ala Ile Trp Ile Pro Pro Ala Ser 
        35                  40                  45              


Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro Tyr Asp Tyr 
    50                  55                  60                  


Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Thr Val Glu Thr Arg Phe 
65                  70                  75                  80  


Gly Ser Lys Gln Glu Leu Val Asn Met Ile Asn Thr Ala His Ala Tyr 
                85                  90                  95      


Gly Met Lys Val Ile Ala Asp Ile Val Ile Asn His Arg Ala Gly Gly 
            100                 105                 110         


Asp Leu Glu Trp Asn Pro Phe Val Asn Asp Tyr Thr Trp Thr Asp Phe 
        115                 120                 125             


Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu Asp Phe His 
    130                 135                 140                 


Pro Asn Glu Leu His Ala Gly Asp Ser Gly Thr Phe Gly Gly Tyr Pro 
145                 150                 155                 160 


Asp Ile Cys His Asp Lys Ser Trp Asp Gln Tyr Trp Leu Trp Ala Ser 
                165                 170                 175     


Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Ile Asp Ala Trp 
            180                 185                 190         


Arg Phe Asp Tyr Val Lys Gly Tyr Ala Pro Trp Val Val Lys Asp Trp 
        195                 200                 205             


Leu Asn Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp Thr Asn 
    210                 215                 220                 


Val Asp Ala Leu Leu Asn Trp Ala Tyr Ala Ser Gly Ala Lys Val Phe 
225                 230                 235                 240 


Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn Asn Asn 
                245                 250                 255     


Ile Pro Ala Leu Val Asp Ala Leu Arg Tyr Gly Gln Thr Val Val Ser 
            260                 265                 270         


Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His Asp Thr Asp 
        275                 280                 285             


Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr Tyr Glu 
    290                 295                 300                 


Gly Gln Pro Met Ile Phe Tyr Arg Asp Tyr Glu Glu Trp Leu Asn Lys 
305                 310                 315                 320 


Asp Arg Leu Lys Asn Leu Ile Trp Ile His Asp His Leu Ala Gly Gly 
                325                 330                 335     


Ser Thr Asp Ile Val Tyr Tyr Asp Ser Asp Glu Leu Ile Phe Val Arg 
            340                 345                 350         


Asn Gly Tyr Gly Ser Lys Pro Gly Leu Ile Thr Tyr Ile Asn Leu Gly 
        355                 360                 365             


Ser Ser Lys Ala Gly Arg Trp Val Tyr Val Pro Lys Phe Ala Gly Ser 
    370                 375                 380                 


Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Val Asp Lys Trp 
385                 390                 395                 400 


Val Asp Ser Ser Gly Trp Val Tyr Leu Glu Ala Pro Ala His Asp Pro 
                405                 410                 415     


Ala Asn Gly Gln Tyr Gly Tyr Ser Val Trp Ser Tyr Cys Gly Val Gly 
            420                 425                 430         


<210>  56
<211>  440
<212>  PRT
<213>  Thermococcus eurythermalis

<400>  56

Gln Pro Ala Gly Ala Ala Lys Tyr Leu Glu Leu Glu Glu Gly Gly Val 
1               5                   10                  15      


Ile Met Gln Ala Phe Tyr Trp Asp Val Pro Ser Gly Gly Ile Trp Trp 
            20                  25                  30          


Asp Thr Ile Arg Gln Lys Ile Pro Glu Trp Tyr Asp Ala Gly Ile Ser 
        35                  40                  45              


Ala Ile Trp Ile Pro Pro Ala Ser Lys Gly Met Gly Gly Ala Tyr Ser 
    50                  55                  60                  


Met Gly Tyr Asp Pro Tyr Asp Phe Phe Asp Leu Gly Glu Tyr Asp Gln 
65                  70                  75                  80  


Lys Gly Thr Val Glu Thr Arg Phe Gly Ser Lys Gln Glu Leu Val Asn 
                85                  90                  95      


Met Ile Asn Thr Ala His Ala Tyr Gly Ile Lys Val Ile Ala Asp Ile 
            100                 105                 110         


Val Ile Asn His Arg Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe Val 
        115                 120                 125             


Asn Asp Tyr Thr Trp Thr Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr 
    130                 135                 140                 


Thr Ala Asn Tyr Leu Asp Phe His Pro Asn Glu Val Lys Cys Cys Asp 
145                 150                 155                 160 


Glu Gly Thr Phe Gly Gly Phe Pro Asp Ile Ala His Glu Lys Ser Trp 
                165                 170                 175     


Asp Gln Tyr Trp Leu Trp Ala Ser Asn Glu Ser Tyr Ala Ala Tyr Leu 
            180                 185                 190         


Arg Ser Ile Gly Val Asp Ala Trp Arg Phe Asp Tyr Val Lys Gly Tyr 
        195                 200                 205             


Gly Ala Trp Val Val Lys Asp Trp Leu Asp Trp Trp Gly Gly Trp Ala 
    210                 215                 220                 


Val Gly Glu Tyr Trp Asp Thr Asn Val Asp Ala Leu Leu Asn Trp Ala 
225                 230                 235                 240 


Tyr Ser Ser Asp Ala Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met 
                245                 250                 255     


Asp Ala Ala Phe Asp Asn Lys Asn Ile Pro Ala Leu Val Glu Ala Leu 
            260                 265                 270         


Lys Asn Gly Gly Thr Val Val Ser Arg Asp Pro Phe Lys Ala Val Thr 
        275                 280                 285             


Phe Val Ala Asn His Asp Thr Asp Ile Ile Trp Asn Lys Tyr Pro Ala 
    290                 295                 300                 


Tyr Ala Phe Ile Leu Thr Tyr Glu Gly Gln Pro Thr Ile Phe Tyr Arg 
305                 310                 315                 320 


Asp Tyr Glu Glu Trp Leu Asn Lys Asp Arg Leu Lys Asn Leu Ile Trp 
                325                 330                 335     


Ile His Asp His Leu Ala Gly Gly Ser Thr Asp Ile Val Tyr Tyr Asp 
            340                 345                 350         


Asn Asp Glu Leu Ile Phe Val Arg Asn Gly Tyr Gly Asp Lys Pro Gly 
        355                 360                 365             


Leu Ile Thr Tyr Ile Asn Leu Gly Ser Ser Lys Ala Gly Arg Trp Val 
    370                 375                 380                 


Tyr Val Pro Lys Phe Ala Gly Ala Cys Ile His Glu Tyr Thr Gly Asn 
385                 390                 395                 400 


Leu Gly Gly Trp Val Asp Lys Trp Val Asp Ser Ser Gly Trp Val Tyr 
                405                 410                 415     


Leu Glu Ala Pro Ala His Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr Ser 
            420                 425                 430         


Val Trp Ser Tyr Cys Gly Val Gly 
        435                 440 


<210>  57
<211>  432
<212>  PRT
<213>  Thermococcus hydrothermalis

<400>  57

Glu Thr Leu Glu Asn Gly Gly Val Ile Met Gln Ala Phe Tyr Trp Asp 
1               5                   10                  15      


Val Pro Gly Gly Gly Ile Trp Trp Asp Thr Ile Ala Gln Lys Ile Pro 
            20                  25                  30          


Asp Trp Ala Ser Ala Gly Ile Ser Ala Ile Trp Ile Pro Pro Ala Ser 
        35                  40                  45              


Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro Tyr Asp Phe 
    50                  55                  60                  


Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Ser Val Glu Thr Arg Phe 
65                  70                  75                  80  


Gly Ser Lys Glu Glu Leu Val Asn Met Ile Asn Thr Ala His Ala His 
                85                  90                  95      


Asn Met Lys Val Ile Ala Asp Ile Val Ile Asn His Arg Ala Gly Gly 
            100                 105                 110         


Asp Leu Glu Trp Asn Pro Phe Thr Asn Ser Tyr Thr Trp Thr Asp Phe 
        115                 120                 125             


Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu Asp Phe His 
    130                 135                 140                 


Pro Asn Glu Leu His Ala Gly Asp Ser Gly Thr Phe Gly Gly Tyr Pro 
145                 150                 155                 160 


Asp Ile Cys His Asp Lys Ser Trp Asp Gln His Trp Leu Trp Ala Ser 
                165                 170                 175     


Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Ile Asp Ala Trp 
            180                 185                 190         


Arg Phe Asp Tyr Val Lys Gly Tyr Ala Pro Trp Val Val Lys Asn Trp 
        195                 200                 205             


Leu Asn Arg Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp Thr Asn 
    210                 215                 220                 


Val Asp Ala Leu Leu Ser Trp Ala Tyr Asp Ser Gly Ala Lys Val Phe 
225                 230                 235                 240 


Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn Asn Asn 
                245                 250                 255     


Ile Pro Ala Leu Val Asp Ala Leu Lys Asn Gly Gly Thr Val Val Ser 
            260                 265                 270         


Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His Asp Thr Asn 
        275                 280                 285             


Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr Tyr Glu 
    290                 295                 300                 


Gly Gln Pro Ala Ile Phe Tyr Arg Asp Tyr Glu Glu Trp Leu Asn Lys 
305                 310                 315                 320 


Asp Arg Leu Arg Asn Leu Ile Trp Ile His Asp His Leu Ala Gly Gly 
                325                 330                 335     


Ser Thr Asp Ile Ile Tyr Tyr Asp Ser Asp Glu Leu Ile Phe Val Arg 
            340                 345                 350         


Asn Gly Tyr Gly Asp Lys Pro Gly Leu Ile Thr Tyr Ile Asn Leu Gly 
        355                 360                 365             


Ser Ser Lys Ala Gly Arg Trp Val Tyr Val Pro Lys Phe Ala Gly Ser 
    370                 375                 380                 


Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Ile Asp Lys Trp 
385                 390                 395                 400 


Val Asp Ser Ser Gly Arg Val Tyr Leu Glu Ala Pro Ala His Asp Pro 
                405                 410                 415     


Ala Asn Gly Gln Tyr Gly Tyr Ser Val Trp Ser Tyr Cys Gly Val Gly 
            420                 425                 430         


<210>  58
<211>  434
<212>  PRT
<213>  Pyrococcus furiosus

<400>  58

Lys Tyr Leu Glu Leu Glu Glu Gly Gly Val Ile Met Gln Ala Phe Tyr 
1               5                   10                  15      


Trp Asp Val Pro Gly Gly Gly Ile Trp Trp Asp His Ile Arg Ser Lys 
            20                  25                  30          


Ile Pro Glu Trp Tyr Glu Ala Gly Ile Ser Ala Ile Trp Leu Pro Pro 
        35                  40                  45              


Pro Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro Tyr 
    50                  55                  60                  


Asp Tyr Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Thr Val Glu Thr 
65                  70                  75                  80  


Arg Phe Gly Ser Lys Glu Glu Leu Val Arg Leu Ile Gln Thr Ala His 
                85                  90                  95      


Ala Tyr Gly Ile Lys Val Ile Ala Asp Val Val Ile Asn His Arg Ala 
            100                 105                 110         


Gly Gly Asp Leu Glu Trp Asn Pro Phe Val Gly Asp Tyr Thr Trp Thr 
        115                 120                 125             


Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu Asp 
    130                 135                 140                 


Phe His Pro Asn Glu Leu His Cys Cys Asp Glu Gly Thr Phe Gly Gly 
145                 150                 155                 160 


Phe Pro Asp Ile Cys His His Lys Glu Trp Asp Gln Tyr Trp Leu Trp 
                165                 170                 175     


Lys Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Phe Asp 
            180                 185                 190         


Gly Trp Arg Phe Asp Tyr Val Lys Gly Tyr Gly Ala Trp Val Val Arg 
        195                 200                 205             


Asp Trp Leu Asn Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp 
    210                 215                 220                 


Thr Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Glu Ser Gly Ala Lys 
225                 230                 235                 240 


Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn 
                245                 250                 255     


Asn Asn Ile Pro Ala Leu Val Tyr Ala Leu Gln Asn Gly Gln Thr Val 
            260                 265                 270         


Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His Asp 
        275                 280                 285             


Thr Asp Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr 
    290                 295                 300                 


Tyr Glu Gly Gln Pro Val Ile Phe Tyr Arg Asp Phe Glu Glu Trp Leu 
305                 310                 315                 320 


Asn Lys Asp Lys Leu Ile Asn Leu Ile Trp Ile His Asp His Leu Ala 
                325                 330                 335     


Gly Gly Ser Thr Thr Ile Val Tyr Tyr Asp Asn Asp Glu Leu Ile Phe 
            340                 345                 350         


Val Arg Asn Gly Asp Ser Arg Arg Pro Gly Leu Ile Thr Tyr Ile Asn 
        355                 360                 365             


Leu Ser Pro Asn Trp Val Gly Arg Trp Val Tyr Val Pro Lys Phe Ala 
    370                 375                 380                 


Gly Ala Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Val Asp 
385                 390                 395                 400 


Lys Arg Val Asp Ser Ser Gly Trp Val Tyr Leu Glu Ala Pro Pro His 
                405                 410                 415     


Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr Cys Gly 
            420                 425                 430         


Val Gly 
        


<210>  59
<211>  436
<212>  PRT
<213>  Thermococcus gammatolerans

<400>  59

Met Lys Tyr Ser Glu Leu Glu Gln Gly Gly Val Ile Met Gln Ala Phe 
1               5                   10                  15      


Tyr Trp Asp Val Pro Ala Gly Gly Ile Trp Trp Asp Thr Ile Arg Gln 
            20                  25                  30          


Lys Ile Pro Glu Trp Tyr Asp Ala Gly Ile Ser Ala Ile Trp Ile Pro 
        35                  40                  45              


Pro Ala Ser Lys Gly Met Gly Gly Ala Tyr Ser Met Gly Tyr Asp Pro 
    50                  55                  60                  


Tyr Asp Tyr Phe Asp Leu Gly Glu Phe Tyr Gln Lys Gly Thr Val Glu 
65                  70                  75                  80  


Thr Arg Phe Gly Ser Lys Glu Glu Leu Val Asn Met Ile Ser Thr Ala 
                85                  90                  95      


His Arg Tyr Gly Ile Lys Val Ile Ala Asp Ile Val Ile Asn His Arg 
            100                 105                 110         


Ala Gly Gly Asp Leu Glu Trp Asn Pro Tyr Val Gly Asp Tyr Thr Trp 
        115                 120                 125             


Thr Asp Phe Ser Gln Val Ala Ser Gly Lys Tyr Lys Ala His Tyr Met 
    130                 135                 140                 


Asp Phe His Pro Asn Asn Tyr Ser Thr Ser Asp Glu Gly Thr Phe Gly 
145                 150                 155                 160 


Gly Phe Pro Asp Ile Asp His Leu Val Pro Phe Asn Lys Tyr Trp Leu 
                165                 170                 175     


Trp Ala Ser Asp Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Val 
            180                 185                 190         


Asp Ala Trp Arg Phe Asp Tyr Val Lys Gly Tyr Gly Ala Trp Val Val 
        195                 200                 205             


Lys Asp Trp Leu Ser Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp 
    210                 215                 220                 


Asp Thr Asp Val Asn Ala Leu Leu Asn Trp Ala Tyr Asp Ser Gly Ala 
225                 230                 235                 240 


Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp 
                245                 250                 255     


Asn Lys Asn Ile Pro Ala Leu Val Tyr Ala Ile Gln Asn Gly Gly Thr 
            260                 265                 270         


Val Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His 
        275                 280                 285             


Asp Thr Asn Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu 
    290                 295                 300                 


Thr Tyr Glu Gly Gln Pro Val Ile Phe Tyr Arg Asp Tyr Glu Glu Trp 
305                 310                 315                 320 


Leu Asn Lys Asp Lys Leu Asn Asn Leu Ile Trp Ile His Glu His Leu 
                325                 330                 335     


Ala Gly Gly Ser Thr Lys Ile Leu Tyr Tyr Asp Asp Asp Glu Leu Ile 
            340                 345                 350         


Phe Met Arg Glu Gly Tyr Gly Asp Arg Pro Gly Leu Ile Thr Tyr Ile 
        355                 360                 365             


Asn Leu Gly Ser Gly Trp Ala Glu Arg Trp Val Asn Val Gly Ser Lys 
    370                 375                 380                 


Phe Ala Gly Tyr Thr Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp 
385                 390                 395                 400 


Val Asp Arg Tyr Val Tyr Tyr Asn Gly Trp Val Lys Leu Thr Ala Pro 
                405                 410                 415     


Pro His Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr 
            420                 425                 430         


Ala Gly Val Gly 
        435     


<210>  60
<211>  433
<212>  PRT
<213>  Thermococcus thioreducens

<400>  60

Met Glu Thr Leu Glu Asn Gly Gly Val Ile Met Gln Ala Phe Tyr Trp 
1               5                   10                  15      


Asp Val Pro Met Gly Gly Ile Trp Trp Asp Thr Ile Ala Gln Lys Ile 
            20                  25                  30          


Pro Asp Trp Ala Ser Ala Gly Ile Ser Ala Ile Trp Ile Pro Pro Ala 
        35                  40                  45              


Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro Tyr Asp 
    50                  55                  60                  


Tyr Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Thr Val Glu Thr Arg 
65                  70                  75                  80  


Phe Gly Ser Lys Gln Glu Leu Val Asn Met Ile Asn Thr Ala His Ala 
                85                  90                  95      


Tyr Gly Met Lys Val Ile Ala Asp Ile Val Ile Asn His Arg Ala Gly 
            100                 105                 110         


Gly Asp Leu Glu Trp Asn Pro Phe Val Asn Asp Tyr Thr Trp Thr Asp 
        115                 120                 125             


Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu Asp Phe 
    130                 135                 140                 


His Pro Asn Glu Leu His Ala Gly Asp Ser Gly Thr Phe Gly Gly Tyr 
145                 150                 155                 160 


Pro Asp Ile Cys His Asp Lys Ser Trp Asp Gln Tyr Trp Leu Trp Ala 
                165                 170                 175     


Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Ile Asp Ala 
            180                 185                 190         


Trp Arg Phe Asp Tyr Val Lys Gly Tyr Ala Pro Trp Val Val Lys Asp 
        195                 200                 205             


Trp Leu Asn Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp Thr 
    210                 215                 220                 


Asn Val Asp Ala Leu Leu Asn Trp Ala Tyr Ala Ser Gly Ala Lys Val 
225                 230                 235                 240 


Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn Asn 
                245                 250                 255     


Asn Ile Pro Ala Leu Val Asp Ala Leu Arg Tyr Gly Gln Thr Val Val 
            260                 265                 270         


Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His Asp Thr 
        275                 280                 285             


Asp Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr Tyr 
    290                 295                 300                 


Glu Gly Gln Pro Met Ile Phe Tyr Arg Asp Tyr Glu Glu Trp Leu Asn 
305                 310                 315                 320 


Lys Asp Arg Leu Lys Asn Leu Ile Trp Ile His Asp His Leu Ala Gly 
                325                 330                 335     


Gly Ser Thr Asp Ile Val Tyr Tyr Asp Ser Asp Glu Leu Ile Phe Val 
            340                 345                 350         


Arg Asn Gly Tyr Gly Ser Lys Pro Gly Leu Ile Thr Tyr Ile Asn Leu 
        355                 360                 365             


Gly Ser Ser Lys Ala Gly Arg Trp Val Tyr Val Pro Lys Phe Ala Gly 
    370                 375                 380                 


Ser Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Val Asp Lys 
385                 390                 395                 400 


Trp Val Asp Ser Ser Gly Trp Val Tyr Leu Glu Ala Pro Ala His Asp 
                405                 410                 415     


Pro Ala Asn Gly Gln Tyr Gly Tyr Ser Val Trp Ser Tyr Cys Gly Val 
            420                 425                 430         


Gly 
    


<210>  61
<211>  441
<212>  PRT
<213>  Thermococcus eurythermalis

<400>  61

Met Gln Pro Ala Gly Ala Ala Lys Tyr Leu Glu Leu Glu Glu Gly Gly 
1               5                   10                  15      


Val Ile Met Gln Ala Phe Tyr Trp Asp Val Pro Ser Gly Gly Ile Trp 
            20                  25                  30          


Trp Asp Thr Ile Arg Gln Lys Ile Pro Glu Trp Tyr Asp Ala Gly Ile 
        35                  40                  45              


Ser Ala Ile Trp Ile Pro Pro Ala Ser Lys Gly Met Gly Gly Ala Tyr 
    50                  55                  60                  


Ser Met Gly Tyr Asp Pro Tyr Asp Phe Phe Asp Leu Gly Glu Tyr Asp 
65                  70                  75                  80  


Gln Lys Gly Thr Val Glu Thr Arg Phe Gly Ser Lys Gln Glu Leu Val 
                85                  90                  95      


Asn Met Ile Asn Thr Ala His Ala Tyr Gly Ile Lys Val Ile Ala Asp 
            100                 105                 110         


Ile Val Ile Asn His Arg Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe 
        115                 120                 125             


Val Asn Asp Tyr Thr Trp Thr Asp Phe Ser Lys Val Ala Ser Gly Lys 
    130                 135                 140                 


Tyr Thr Ala Asn Tyr Leu Asp Phe His Pro Asn Glu Val Lys Cys Cys 
145                 150                 155                 160 


Asp Glu Gly Thr Phe Gly Gly Phe Pro Asp Ile Ala His Glu Lys Ser 
                165                 170                 175     


Trp Asp Gln Tyr Trp Leu Trp Ala Ser Asn Glu Ser Tyr Ala Ala Tyr 
            180                 185                 190         


Leu Arg Ser Ile Gly Val Asp Ala Trp Arg Phe Asp Tyr Val Lys Gly 
        195                 200                 205             


Tyr Gly Ala Trp Val Val Lys Asp Trp Leu Asp Trp Trp Gly Gly Trp 
    210                 215                 220                 


Ala Val Gly Glu Tyr Trp Asp Thr Asn Val Asp Ala Leu Leu Asn Trp 
225                 230                 235                 240 


Ala Tyr Ser Ser Asp Ala Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys 
                245                 250                 255     


Met Asp Ala Ala Phe Asp Asn Lys Asn Ile Pro Ala Leu Val Glu Ala 
            260                 265                 270         


Leu Lys Asn Gly Gly Thr Val Val Ser Arg Asp Pro Phe Lys Ala Val 
        275                 280                 285             


Thr Phe Val Ala Asn His Asp Thr Asp Ile Ile Trp Asn Lys Tyr Pro 
    290                 295                 300                 


Ala Tyr Ala Phe Ile Leu Thr Tyr Glu Gly Gln Pro Thr Ile Phe Tyr 
305                 310                 315                 320 


Arg Asp Tyr Glu Glu Trp Leu Asn Lys Asp Arg Leu Lys Asn Leu Ile 
                325                 330                 335     


Trp Ile His Asp His Leu Ala Gly Gly Ser Thr Asp Ile Val Tyr Tyr 
            340                 345                 350         


Asp Asn Asp Glu Leu Ile Phe Val Arg Asn Gly Tyr Gly Asp Lys Pro 
        355                 360                 365             


Gly Leu Ile Thr Tyr Ile Asn Leu Gly Ser Ser Lys Ala Gly Arg Trp 
    370                 375                 380                 


Val Tyr Val Pro Lys Phe Ala Gly Ala Cys Ile His Glu Tyr Thr Gly 
385                 390                 395                 400 


Asn Leu Gly Gly Trp Val Asp Lys Trp Val Asp Ser Ser Gly Trp Val 
                405                 410                 415     


Tyr Leu Glu Ala Pro Ala His Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr 
            420                 425                 430         


Ser Val Trp Ser Tyr Cys Gly Val Gly 
        435                 440     


<210>  62
<211>  433
<212>  PRT
<213>  Thermococcus hydrothermalis

<400>  62

Met Glu Thr Leu Glu Asn Gly Gly Val Ile Met Gln Ala Phe Tyr Trp 
1               5                   10                  15      


Asp Val Pro Gly Gly Gly Ile Trp Trp Asp Thr Ile Ala Gln Lys Ile 
            20                  25                  30          


Pro Asp Trp Ala Ser Ala Gly Ile Ser Ala Ile Trp Ile Pro Pro Ala 
        35                  40                  45              


Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro Tyr Asp 
    50                  55                  60                  


Phe Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Ser Val Glu Thr Arg 
65                  70                  75                  80  


Phe Gly Ser Lys Glu Glu Leu Val Asn Met Ile Asn Thr Ala His Ala 
                85                  90                  95      


His Asn Met Lys Val Ile Ala Asp Ile Val Ile Asn His Arg Ala Gly 
            100                 105                 110         


Gly Asp Leu Glu Trp Asn Pro Phe Thr Asn Ser Tyr Thr Trp Thr Asp 
        115                 120                 125             


Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu Asp Phe 
    130                 135                 140                 


His Pro Asn Glu Leu His Ala Gly Asp Ser Gly Thr Phe Gly Gly Tyr 
145                 150                 155                 160 


Pro Asp Ile Cys His Asp Lys Ser Trp Asp Gln His Trp Leu Trp Ala 
                165                 170                 175     


Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Ile Asp Ala 
            180                 185                 190         


Trp Arg Phe Asp Tyr Val Lys Gly Tyr Ala Pro Trp Val Val Lys Asn 
        195                 200                 205             


Trp Leu Asn Arg Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp Thr 
    210                 215                 220                 


Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Asp Ser Gly Ala Lys Val 
225                 230                 235                 240 


Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn Asn 
                245                 250                 255     


Asn Ile Pro Ala Leu Val Asp Ala Leu Lys Asn Gly Gly Thr Val Val 
            260                 265                 270         


Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His Asp Thr 
        275                 280                 285             


Asn Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr Tyr 
    290                 295                 300                 


Glu Gly Gln Pro Ala Ile Phe Tyr Arg Asp Tyr Glu Glu Trp Leu Asn 
305                 310                 315                 320 


Lys Asp Arg Leu Arg Asn Leu Ile Trp Ile His Asp His Leu Ala Gly 
                325                 330                 335     


Gly Ser Thr Asp Ile Ile Tyr Tyr Asp Ser Asp Glu Leu Ile Phe Val 
            340                 345                 350         


Arg Asn Gly Tyr Gly Asp Lys Pro Gly Leu Ile Thr Tyr Ile Asn Leu 
        355                 360                 365             


Gly Ser Ser Lys Ala Gly Arg Trp Val Tyr Val Pro Lys Phe Ala Gly 
    370                 375                 380                 


Ser Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Ile Asp Lys 
385                 390                 395                 400 


Trp Val Asp Ser Ser Gly Arg Val Tyr Leu Glu Ala Pro Ala His Asp 
                405                 410                 415     


Pro Ala Asn Gly Gln Tyr Gly Tyr Ser Val Trp Ser Tyr Cys Gly Val 
            420                 425                 430         


Gly 
    


<210>  63
<211>  436
<212>  PRT
<213>  Pyrococcus furiosus

<400>  63

Met Ala Lys Tyr Leu Glu Leu Glu Glu Gly Gly Val Ile Met Gln Ala 
1               5                   10                  15      


Phe Tyr Trp Asp Val Pro Gly Gly Gly Ile Trp Trp Asp His Ile Arg 
            20                  25                  30          


Ser Lys Ile Pro Glu Trp Tyr Glu Ala Gly Ile Ser Ala Ile Trp Leu 
        35                  40                  45              


Pro Pro Pro Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp 
    50                  55                  60                  


Pro Tyr Asp Tyr Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Thr Val 
65                  70                  75                  80  


Glu Thr Arg Phe Gly Ser Lys Glu Glu Leu Val Arg Leu Ile Gln Thr 
                85                  90                  95      


Ala His Ala Tyr Gly Ile Lys Val Ile Ala Asp Val Val Ile Asn His 
            100                 105                 110         


Arg Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe Val Gly Asp Tyr Thr 
        115                 120                 125             


Trp Thr Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr 
    130                 135                 140                 


Leu Asp Phe His Pro Asn Glu Leu His Cys Cys Asp Glu Gly Thr Phe 
145                 150                 155                 160 


Gly Gly Phe Pro Asp Ile Cys His His Lys Glu Trp Asp Gln Tyr Trp 
                165                 170                 175     


Leu Trp Lys Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly 
            180                 185                 190         


Phe Asp Gly Trp Arg Phe Asp Tyr Val Lys Gly Tyr Gly Ala Trp Val 
        195                 200                 205             


Val Arg Asp Trp Leu Asn Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr 
    210                 215                 220                 


Trp Asp Thr Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Glu Ser Gly 
225                 230                 235                 240 


Ala Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe 
                245                 250                 255     


Asp Asn Asn Asn Ile Pro Ala Leu Val Tyr Ala Leu Gln Asn Gly Gln 
            260                 265                 270         


Thr Val Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn 
        275                 280                 285             


His Asp Thr Asp Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile 
    290                 295                 300                 


Leu Thr Tyr Glu Gly Gln Pro Val Ile Phe Tyr Arg Asp Phe Glu Glu 
305                 310                 315                 320 


Trp Leu Asn Lys Asp Lys Leu Ile Asn Leu Ile Trp Ile His Asp His 
                325                 330                 335     


Leu Ala Gly Gly Ser Thr Thr Ile Val Tyr Tyr Asp Asn Asp Glu Leu 
            340                 345                 350         


Ile Phe Val Arg Asn Gly Asp Ser Arg Arg Pro Gly Leu Ile Thr Tyr 
        355                 360                 365             


Ile Asn Leu Ser Pro Asn Trp Val Gly Arg Trp Val Tyr Val Pro Lys 
    370                 375                 380                 


Phe Ala Gly Ala Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp 
385                 390                 395                 400 


Val Asp Lys Arg Val Asp Ser Ser Gly Trp Val Tyr Leu Glu Ala Pro 
                405                 410                 415     


Pro His Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr 
            420                 425                 430         


Cys Gly Val Gly 
        435     


<210>  64
<211>  435
<212>  PRT
<213>  Pyrococcus furiosus

<400>  64

Met Lys Tyr Leu Glu Leu Glu Glu Gly Gly Val Ile Met Gln Ala Phe 
1               5                   10                  15      


Tyr Trp Asp Val Pro Gly Gly Gly Ile Trp Trp Asp His Ile Arg Ser 
            20                  25                  30          


Lys Ile Pro Glu Trp Tyr Glu Ala Gly Ile Ser Ala Ile Trp Leu Pro 
        35                  40                  45              


Pro Pro Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro 
    50                  55                  60                  


Tyr Asp Tyr Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Thr Val Glu 
65                  70                  75                  80  


Thr Arg Phe Gly Ser Lys Glu Glu Leu Val Arg Leu Ile Gln Thr Ala 
                85                  90                  95      


His Ala Tyr Gly Ile Lys Val Ile Ala Asp Val Val Ile Asn His Arg 
            100                 105                 110         


Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe Val Gly Asp Tyr Thr Trp 
        115                 120                 125             


Thr Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu 
    130                 135                 140                 


Asp Phe His Pro Asn Glu Leu His Cys Cys Asp Glu Gly Thr Phe Gly 
145                 150                 155                 160 


Gly Phe Pro Asp Ile Cys His His Lys Glu Trp Asp Gln Tyr Trp Leu 
                165                 170                 175     


Trp Lys Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Phe 
            180                 185                 190         


Asp Gly Trp Arg Phe Asp Tyr Val Lys Gly Tyr Gly Ala Trp Val Val 
        195                 200                 205             


Arg Asp Trp Leu Asn Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp 
    210                 215                 220                 


Asp Thr Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Glu Ser Gly Ala 
225                 230                 235                 240 


Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp 
                245                 250                 255     


Asn Asn Asn Ile Pro Ala Leu Val Tyr Ala Leu Gln Asn Gly Gln Thr 
            260                 265                 270         


Val Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His 
        275                 280                 285             


Asp Thr Asp Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu 
    290                 295                 300                 


Thr Tyr Glu Gly Gln Pro Val Ile Phe Tyr Arg Asp Phe Glu Glu Trp 
305                 310                 315                 320 


Leu Asn Lys Asp Lys Leu Ile Asn Leu Ile Trp Ile His Asp His Leu 
                325                 330                 335     


Ala Gly Gly Ser Thr Thr Ile Val Tyr Tyr Asp Asn Asp Glu Leu Ile 
            340                 345                 350         


Phe Val Arg Asn Gly Asp Ser Arg Arg Pro Gly Leu Ile Thr Tyr Ile 
        355                 360                 365             


Asn Leu Ser Pro Asn Trp Val Gly Arg Trp Val Tyr Val Pro Lys Phe 
    370                 375                 380                 


Ala Gly Ala Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Val 
385                 390                 395                 400 


Asp Lys Arg Val Asp Ser Ser Gly Trp Val Tyr Leu Glu Ala Pro Pro 
                405                 410                 415     


His Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr Cys 
            420                 425                 430         


Gly Val Gly 
        435 


<210>  65
<211>  435
<212>  PRT
<213>  Pyrococcus furiosus

<400>  65

Met Lys Tyr Ser Glu Leu Glu Glu Gly Gly Val Ile Met Gln Ala Phe 
1               5                   10                  15      


Tyr Trp Asp Val Pro Gly Gly Gly Ile Trp Trp Asp His Ile Arg Ser 
            20                  25                  30          


Lys Ile Pro Glu Trp Tyr Glu Ala Gly Ile Ser Ala Ile Trp Leu Pro 
        35                  40                  45              


Pro Pro Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro 
    50                  55                  60                  


Tyr Asp Tyr Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Thr Val Glu 
65                  70                  75                  80  


Thr Arg Phe Gly Ser Lys Glu Glu Leu Val Arg Leu Ile Gln Thr Ala 
                85                  90                  95      


His Ala Tyr Gly Ile Lys Val Ile Ala Asp Val Val Ile Asn His Arg 
            100                 105                 110         


Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe Val Gly Asp Tyr Thr Trp 
        115                 120                 125             


Thr Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu 
    130                 135                 140                 


Asp Phe His Pro Asn Glu Leu His Cys Cys Asp Glu Gly Thr Phe Gly 
145                 150                 155                 160 


Gly Phe Pro Asp Ile Cys His His Lys Glu Trp Asp Gln Tyr Trp Leu 
                165                 170                 175     


Trp Lys Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Phe 
            180                 185                 190         


Asp Gly Trp Arg Phe Asp Tyr Val Lys Gly Tyr Gly Ala Trp Val Val 
        195                 200                 205             


Arg Asp Trp Leu Asn Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp 
    210                 215                 220                 


Asp Thr Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Glu Ser Gly Ala 
225                 230                 235                 240 


Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp 
                245                 250                 255     


Asn Asn Asn Ile Pro Ala Leu Val Tyr Ala Leu Gln Asn Gly Gln Thr 
            260                 265                 270         


Val Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His 
        275                 280                 285             


Asp Thr Asp Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu 
    290                 295                 300                 


Thr Tyr Glu Gly Gln Pro Val Ile Phe Tyr Arg Asp Phe Glu Glu Trp 
305                 310                 315                 320 


Leu Asn Lys Asp Lys Leu Ile Asn Leu Ile Trp Ile His Asp His Leu 
                325                 330                 335     


Ala Gly Gly Ser Thr Thr Ile Val Tyr Tyr Asp Asn Asp Glu Leu Ile 
            340                 345                 350         


Phe Val Arg Asn Gly Asp Ser Arg Arg Pro Gly Leu Ile Thr Tyr Ile 
        355                 360                 365             


Asn Leu Ser Pro Asn Trp Val Gly Arg Trp Val Tyr Val Pro Lys Phe 
    370                 375                 380                 


Ala Gly Ala Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Val 
385                 390                 395                 400 


Asp Lys Arg Val Asp Ser Ser Gly Trp Val Tyr Leu Glu Ala Pro Pro 
                405                 410                 415     


His Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr Cys 
            420                 425                 430         


Gly Val Gly 
        435 


<210>  66
<211>  436
<212>  PRT
<213>  Pyrococcus furiosus

<400>  66

Met Ser Lys Tyr Leu Glu Leu Glu Glu Gly Gly Val Ile Met Gln Ala 
1               5                   10                  15      


Phe Tyr Trp Asp Val Pro Gly Gly Gly Ile Trp Trp Asp His Ile Arg 
            20                  25                  30          


Ser Lys Ile Pro Glu Trp Tyr Glu Ala Gly Ile Ser Ala Ile Trp Leu 
        35                  40                  45              


Pro Pro Pro Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp 
    50                  55                  60                  


Pro Tyr Asp Tyr Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Thr Val 
65                  70                  75                  80  


Glu Thr Arg Phe Gly Ser Lys Glu Glu Leu Val Arg Leu Ile Gln Thr 
                85                  90                  95      


Ala His Ala Tyr Gly Ile Lys Val Ile Ala Asp Val Val Ile Asn His 
            100                 105                 110         


Arg Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe Val Gly Asp Tyr Thr 
        115                 120                 125             


Trp Thr Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr 
    130                 135                 140                 


Leu Asp Phe His Pro Asn Glu Leu His Cys Cys Asp Glu Gly Thr Phe 
145                 150                 155                 160 


Gly Gly Phe Pro Asp Ile Cys His His Lys Glu Trp Asp Gln Tyr Trp 
                165                 170                 175     


Leu Trp Lys Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly 
            180                 185                 190         


Phe Asp Gly Trp Arg Phe Asp Tyr Val Lys Gly Tyr Gly Ala Trp Val 
        195                 200                 205             


Val Arg Asp Trp Leu Asn Trp Trp Gly Gly Trp Ala Val Gly Glu Tyr 
    210                 215                 220                 


Trp Asp Thr Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Glu Ser Gly 
225                 230                 235                 240 


Ala Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe 
                245                 250                 255     


Asp Asn Asn Asn Ile Pro Ala Leu Val Tyr Ala Leu Gln Asn Gly Gln 
            260                 265                 270         


Thr Val Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn 
        275                 280                 285             


His Asp Thr Asp Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile 
    290                 295                 300                 


Leu Thr Tyr Glu Gly Gln Pro Val Ile Phe Tyr Arg Asp Phe Glu Glu 
305                 310                 315                 320 


Trp Leu Asn Lys Asp Lys Leu Ile Asn Leu Ile Trp Ile His Asp His 
                325                 330                 335     


Leu Ala Gly Gly Ser Thr Thr Ile Val Tyr Tyr Asp Asn Asp Glu Leu 
            340                 345                 350         


Ile Phe Val Arg Asn Gly Asp Ser Arg Arg Pro Gly Leu Ile Thr Tyr 
        355                 360                 365             


Ile Asn Leu Ser Pro Asn Trp Val Gly Arg Trp Val Tyr Val Pro Lys 
    370                 375                 380                 


Phe Ala Gly Ala Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp 
385                 390                 395                 400 


Val Asp Lys Arg Val Asp Ser Ser Gly Trp Val Tyr Leu Glu Ala Pro 
                405                 410                 415     


Pro His Asp Pro Ala Asn Gly Tyr Tyr Gly Tyr Ser Val Trp Ser Tyr 
            420                 425                 430         


Cys Gly Val Gly 
        435     


<210>  67
<211>  435
<212>  PRT
<213>  Thermococcus hydrothermalis

<400>  67

Met Lys Tyr Glu Thr Leu Glu Asn Gly Gly Val Ile Met Gln Ala Phe 
1               5                   10                  15      


Tyr Trp Asp Val Pro Gly Gly Gly Ile Trp Trp Asp Thr Ile Ala Gln 
            20                  25                  30          


Lys Ile Pro Asp Trp Ala Ser Ala Gly Ile Ser Ala Ile Trp Ile Pro 
        35                  40                  45              


Pro Ala Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro 
    50                  55                  60                  


Tyr Asp Phe Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Ser Val Glu 
65                  70                  75                  80  


Thr Arg Phe Gly Ser Lys Glu Glu Leu Val Asn Met Ile Asn Thr Ala 
                85                  90                  95      


His Ala His Asn Met Lys Val Ile Ala Asp Ile Val Ile Asn His Arg 
            100                 105                 110         


Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe Thr Asn Ser Tyr Thr Trp 
        115                 120                 125             


Thr Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu 
    130                 135                 140                 


Asp Phe His Pro Asn Glu Leu His Ala Gly Asp Ser Gly Thr Phe Gly 
145                 150                 155                 160 


Gly Tyr Pro Asp Ile Cys His Asp Lys Ser Trp Asp Gln His Trp Leu 
                165                 170                 175     


Trp Ala Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Ile 
            180                 185                 190         


Asp Ala Trp Arg Phe Asp Tyr Val Lys Gly Tyr Ala Pro Trp Val Val 
        195                 200                 205             


Lys Asn Trp Leu Asn Arg Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp 
    210                 215                 220                 


Asp Thr Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Asp Ser Gly Ala 
225                 230                 235                 240 


Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp 
                245                 250                 255     


Asn Asn Asn Ile Pro Ala Leu Val Asp Ala Leu Lys Asn Gly Gly Thr 
            260                 265                 270         


Val Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His 
        275                 280                 285             


Asp Thr Asn Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu 
    290                 295                 300                 


Thr Tyr Glu Gly Gln Pro Ala Ile Phe Tyr Arg Asp Tyr Glu Glu Trp 
305                 310                 315                 320 


Leu Asn Lys Asp Arg Leu Arg Asn Leu Ile Trp Ile His Asp His Leu 
                325                 330                 335     


Ala Gly Gly Ser Thr Asp Ile Ile Tyr Tyr Asp Ser Asp Glu Leu Ile 
            340                 345                 350         


Phe Val Arg Asn Gly Tyr Gly Asp Lys Pro Gly Leu Ile Thr Tyr Ile 
        355                 360                 365             


Asn Leu Gly Ser Ser Lys Ala Gly Arg Trp Val Tyr Val Pro Lys Phe 
    370                 375                 380                 


Ala Gly Ser Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Ile 
385                 390                 395                 400 


Asp Lys Trp Val Asp Ser Ser Gly Arg Val Tyr Leu Glu Ala Pro Ala 
                405                 410                 415     


His Asp Pro Ala Asn Gly Gln Tyr Gly Tyr Ser Val Trp Ser Tyr Cys 
            420                 425                 430         


Gly Val Gly 
        435 


<210>  68
<211>  435
<212>  PRT
<213>  Thermococcus hydrothermalis

<400>  68

Met Lys Tyr Ser Glu Leu Glu Asn Gly Gly Val Ile Met Gln Ala Phe 
1               5                   10                  15      


Tyr Trp Asp Val Pro Gly Gly Gly Ile Trp Trp Asp Thr Ile Ala Gln 
            20                  25                  30          


Lys Ile Pro Asp Trp Ala Ser Ala Gly Ile Ser Ala Ile Trp Ile Pro 
        35                  40                  45              


Pro Ala Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro 
    50                  55                  60                  


Tyr Asp Phe Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Ser Val Glu 
65                  70                  75                  80  


Thr Arg Phe Gly Ser Lys Glu Glu Leu Val Asn Met Ile Asn Thr Ala 
                85                  90                  95      


His Ala His Asn Met Lys Val Ile Ala Asp Ile Val Ile Asn His Arg 
            100                 105                 110         


Ala Gly Gly Asp Leu Glu Trp Asn Pro Phe Thr Asn Ser Tyr Thr Trp 
        115                 120                 125             


Thr Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu 
    130                 135                 140                 


Asp Phe His Pro Asn Glu Leu His Ala Gly Asp Ser Gly Thr Phe Gly 
145                 150                 155                 160 


Gly Tyr Pro Asp Ile Cys His Asp Lys Ser Trp Asp Gln His Trp Leu 
                165                 170                 175     


Trp Ala Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Ile 
            180                 185                 190         


Asp Ala Trp Arg Phe Asp Tyr Val Lys Gly Tyr Ala Pro Trp Val Val 
        195                 200                 205             


Lys Asn Trp Leu Asn Arg Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp 
    210                 215                 220                 


Asp Thr Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Asp Ser Gly Ala 
225                 230                 235                 240 


Lys Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp 
                245                 250                 255     


Asn Asn Asn Ile Pro Ala Leu Val Asp Ala Leu Lys Asn Gly Gly Thr 
            260                 265                 270         


Val Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His 
        275                 280                 285             


Asp Thr Asn Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu 
    290                 295                 300                 


Thr Tyr Glu Gly Gln Pro Ala Ile Phe Tyr Arg Asp Tyr Glu Glu Trp 
305                 310                 315                 320 


Leu Asn Lys Asp Arg Leu Arg Asn Leu Ile Trp Ile His Asp His Leu 
                325                 330                 335     


Ala Gly Gly Ser Thr Asp Ile Ile Tyr Tyr Asp Ser Asp Glu Leu Ile 
            340                 345                 350         


Phe Val Arg Asn Gly Tyr Gly Asp Lys Pro Gly Leu Ile Thr Tyr Ile 
        355                 360                 365             


Asn Leu Gly Ser Ser Lys Ala Gly Arg Trp Val Tyr Val Pro Lys Phe 
    370                 375                 380                 


Ala Gly Ser Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Ile 
385                 390                 395                 400 


Asp Lys Trp Val Asp Ser Ser Gly Arg Val Tyr Leu Glu Ala Pro Ala 
                405                 410                 415     


His Asp Pro Ala Asn Gly Gln Tyr Gly Tyr Ser Val Trp Ser Tyr Cys 
            420                 425                 430         


Gly Val Gly 
        435 


<210>  69
<211>  434
<212>  PRT
<213>  Thermococcus hydrothermalis

<400>  69

Met Ser Glu Thr Leu Glu Asn Gly Gly Val Ile Met Gln Ala Phe Tyr 
1               5                   10                  15      


Trp Asp Val Pro Gly Gly Gly Ile Trp Trp Asp Thr Ile Ala Gln Lys 
            20                  25                  30          


Ile Pro Asp Trp Ala Ser Ala Gly Ile Ser Ala Ile Trp Ile Pro Pro 
        35                  40                  45              


Ala Ser Lys Gly Met Ser Gly Gly Tyr Ser Met Gly Tyr Asp Pro Tyr 
    50                  55                  60                  


Asp Phe Phe Asp Leu Gly Glu Tyr Tyr Gln Lys Gly Ser Val Glu Thr 
65                  70                  75                  80  


Arg Phe Gly Ser Lys Glu Glu Leu Val Asn Met Ile Asn Thr Ala His 
                85                  90                  95      


Ala His Asn Met Lys Val Ile Ala Asp Ile Val Ile Asn His Arg Ala 
            100                 105                 110         


Gly Gly Asp Leu Glu Trp Asn Pro Phe Thr Asn Ser Tyr Thr Trp Thr 
        115                 120                 125             


Asp Phe Ser Lys Val Ala Ser Gly Lys Tyr Thr Ala Asn Tyr Leu Asp 
    130                 135                 140                 


Phe His Pro Asn Glu Leu His Ala Gly Asp Ser Gly Thr Phe Gly Gly 
145                 150                 155                 160 


Tyr Pro Asp Ile Cys His Asp Lys Ser Trp Asp Gln His Trp Leu Trp 
                165                 170                 175     


Ala Ser Asn Glu Ser Tyr Ala Ala Tyr Leu Arg Ser Ile Gly Ile Asp 
            180                 185                 190         


Ala Trp Arg Phe Asp Tyr Val Lys Gly Tyr Ala Pro Trp Val Val Lys 
        195                 200                 205             


Asn Trp Leu Asn Arg Trp Gly Gly Trp Ala Val Gly Glu Tyr Trp Asp 
    210                 215                 220                 


Thr Asn Val Asp Ala Leu Leu Ser Trp Ala Tyr Asp Ser Gly Ala Lys 
225                 230                 235                 240 


Val Phe Asp Phe Pro Leu Tyr Tyr Lys Met Asp Glu Ala Phe Asp Asn 
                245                 250                 255     


Asn Asn Ile Pro Ala Leu Val Asp Ala Leu Lys Asn Gly Gly Thr Val 
            260                 265                 270         


Val Ser Arg Asp Pro Phe Lys Ala Val Thr Phe Val Ala Asn His Asp 
        275                 280                 285             


Thr Asn Ile Ile Trp Asn Lys Tyr Pro Ala Tyr Ala Phe Ile Leu Thr 
    290                 295                 300                 


Tyr Glu Gly Gln Pro Ala Ile Phe Tyr Arg Asp Tyr Glu Glu Trp Leu 
305                 310                 315                 320 


Asn Lys Asp Arg Leu Arg Asn Leu Ile Trp Ile His Asp His Leu Ala 
                325                 330                 335     


Gly Gly Ser Thr Asp Ile Ile Tyr Tyr Asp Ser Asp Glu Leu Ile Phe 
            340                 345                 350         


Val Arg Asn Gly Tyr Gly Asp Lys Pro Gly Leu Ile Thr Tyr Ile Asn 
        355                 360                 365             


Leu Gly Ser Ser Lys Ala Gly Arg Trp Val Tyr Val Pro Lys Phe Ala 
    370                 375                 380                 


Gly Ser Cys Ile His Glu Tyr Thr Gly Asn Leu Gly Gly Trp Ile Asp 
385                 390                 395                 400 


Lys Trp Val Asp Ser Ser Gly Arg Val Tyr Leu Glu Ala Pro Ala His 
                405                 410                 415     


Asp Pro Ala Asn Gly Gln Tyr Gly Tyr Ser Val Trp Ser Tyr Cys Gly 
            420                 425                 430         


Val Gly 
        


<210>  70
<211>  21
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  70

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro 
            20      


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  71

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Ala 
    


<210>  72
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  72

Ala Ala Asn Val Thr Thr Ala Thr Val Ser Gln Glu Ser Thr Thr Leu 
1               5                   10                  15      


Val Thr Ile Thr Ser Cys Glu Asp His Val Cys Ser Glu Thr Val Ser 
            20                  25                  30          


Pro Ala Leu Val Ser Thr Ala Thr Val Thr Val Asp Asp Val Ile Thr 
        35                  40                  45              


Gln Tyr Thr Thr Trp Cys Pro Leu Thr Thr Glu Ala Pro Lys Asn Gly 
    50                  55                  60                  


Thr Ser Thr Ala Ala Pro Val Thr Ser Thr Glu Ala Pro Lys Asn Thr 
65                  70                  75                  80  


Thr Ser Ala Ala Pro Thr His Ser Val Thr Ser Tyr Thr Gly Ala Ala 
                85                  90                  95      


Ala Lys Ala Leu Pro Ala Ala Gly Ala Leu Leu Ala Gly Ala Ala Ala 
            100                 105                 110         


Leu Leu Leu 
        115 


<210>  73
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Starch-binding domain of Aspergillus niger G1 glucoamylase

<400>  73

Cys Thr Thr Pro Thr Ala Val Ala Val Thr Phe Asp Leu Thr Ala Thr 
1               5                   10                  15      


Thr Thr Tyr Gly Glu Asn Ile Tyr Leu Val Gly Ser Ile Ser Gln Leu 
            20                  25                  30          


Gly Asp Trp Glu Thr Ser Asp Gly Ile Ala Leu Ser Ala Asp Lys Tyr 
        35                  40                  45              


Thr Ser Ser Asp Pro Leu Trp Tyr Val Thr Val Thr Leu Pro Ala Gly 
    50                  55                  60                  


Glu Ser Phe Glu Tyr Lys Phe Ile Arg Ile Glu Ser Asp Asp Ser Val 
65                  70                  75                  80  


Glu Trp Glu Ser Asp Pro Asn Arg Glu Tyr Thr Val Pro Gln Ala Cys 
                85                  90                  95      


Gly Thr Ser Thr Ala Thr Val Thr Asp Thr Trp Arg 
            100                 105             


