                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       ECOLE NORMALE SUPRIEURE DE LYON  (ENSL)
       Universit Claude Bernard Lyon 1
       Centre national de la recherche scientifique (CNRS)
       UNIVERSITE PARIS DESCARTES
 
<120>  VPX PROTEIN AS A TRANSGENE ACTIVATOR FOR USE IN GENE THERAPY OR 
       FOR LATENT VIRUS REACTIVATION

<130>  BET19P0478

<150>  EP18305285.1
<151>  2018-03-16

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Human immunodeficiency virus type 2

<400>  1

Met Thr Asp Pro Arg Glu Arg Val Pro Pro Gly Asn Ser Gly Glu Glu 
1               5                   10                  15      


Thr Ile Gly Glu Ala Phe Glu Trp Leu Asp Arg Thr Ile Glu Ala Leu 
            20                  25                  30          


Asn Arg Glu Ala Val Asn His Leu Pro Arg Glu Leu Ile Phe Gln Val 
        35                  40                  45              


Trp Gln Arg Ser Trp Arg Tyr Trp His Asp Asp Gln Gly Met Ser Pro 
    50                  55                  60                  


Ser Tyr Thr Lys Tyr Arg Tyr Leu Cys Leu Met Gln Lys Ala Val Phe 
65                  70                  75                  80  


Ile His Phe Lys Arg Gly Cys Thr Cys Leu Gly Gly Gly His Gly Pro 
                85                  90                  95      


Gly Gly Trp Arg Ser Gly Pro Pro Pro Pro Pro Pro Pro Gly Leu Val 
            100                 105                 110         


<210>  2
<211>  112
<212>  PRT
<213>  Human immunodeficiency virus type 2

<400>  2

Met Thr Asp Pro Arg Glu Thr Val Pro Pro Gly Asn Ser Gly Glu Glu 
1               5                   10                  15      


Thr Ile Gly Glu Ala Phe Ala Trp Leu Asn Arg Thr Val Glu Ala Ile 
            20                  25                  30          


Asn Arg Glu Ala Val Asn His Leu Pro Arg Glu Leu Ile Phe Gln Val 
        35                  40                  45              


Trp Gln Arg Ser Trp Arg Tyr Trp His Asp Glu Gln Gly Met Ser Glu 
    50                  55                  60                  


Ser Tyr Thr Lys Tyr Arg Tyr Leu Cys Ile Met Gln Arg Ala Val Tyr 
65                  70                  75                  80  


Met His Val Arg Lys Gly Cys Thr Cys Leu Gly Arg Gly His Gly Pro 
                85                  90                  95      


Gly Gly Trp Arg Pro Gly Pro Pro Pro Pro Pro Pro Pro Gly Leu Val 
            100                 105                 110         


<210>  3
<211>  119
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  3

Met Ala Ser Gly Arg Gly Pro Arg Glu Asn Arg Pro Gly Glu Val Glu 
1               5                   10                  15      


Ile Trp Asp Leu Asn Arg Glu Pro Trp Asp Glu Trp Leu Arg Asp Met 
            20                  25                  30          


Leu Glu Asp Leu Asn Gln Glu Ala Lys Leu His Phe Gly Arg Glu Leu 
        35                  40                  45              


Leu Phe Gln Val Trp Asn Tyr Cys Gln Glu Glu Gly Glu Arg Arg Gly 
    50                  55                  60                  


Ala Pro Met Thr Glu Arg Ala Tyr Arg Tyr Tyr Arg Leu Val Gln Lys 
65                  70                  75                  80  


Ala Leu Phe Val His Phe Arg Cys Gly Cys Arg Arg Arg Gln Pro Phe 
                85                  90                  95      


Glu Pro Tyr Glu Glu Arg Arg Asp Gly Gln Gly Gly Gly Arg Ala Asn 
            100                 105                 110         


Arg Ala Pro Pro Gly Leu Asp 
        115                 


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  4
ggaaugacac ugugcgcuu                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  5
cggaguugga ggaggacga                                                    19


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
tgtgtgcccg tctgttgtgt                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
gagtcctgcg tcgagagagc                                                   20


<210>  8
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  8
ccctcagacc cttttagtca gtgtggaa                                          28


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  9
tctctagcag tggcgcccga acag                                              24


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10
tcccagctac tggggaggct gagg                                              24


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
gcctcccaaa gtgctgggat tacag                                             25


<210>  12
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
atgccacgta agcgaaactc tggctaacta gggaacccac tg                          42


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
atgccacgta agcgaaact                                                    19


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
gctagagatt ttccacactg actaa                                             25


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  15
cacaacagac gggcacacac tacttga                                           27


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  16
cactcaaggc aagctttatt gaggc                                             25


<210>  17
<211>  112
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  17

Met Ser Asp Pro Arg Glu Arg Ile Pro Pro Gly Asn Ser Gly Glu Glu 
1               5                   10                  15      


Thr Ile Gly Glu Ala Phe Asp Trp Leu Asp Arg Thr Val Glu Glu Ile 
            20                  25                  30          


Asn Arg Ala Ala Val Asn His Leu Pro Arg Glu Leu Ile Phe Gln Val 
        35                  40                  45              


Trp Arg Arg Ser Trp Glu Tyr Trp His Asp Glu Met Gly Met Ser Val 
    50                  55                  60                  


Ser Tyr Thr Lys Tyr Arg Tyr Leu Cys Leu Ile Gln Lys Ala Met Phe 
65                  70                  75                  80  


Met His Cys Lys Lys Gly Cys Arg Cys Leu Gly Gly Glu His Gly Ala 
                85                  90                  95      


Gly Gly Trp Arg Pro Gly Pro Pro Pro Pro Pro Pro Pro Gly Leu Ala 
            100                 105                 110         


<210>  18
<211>  99
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  18

Met Ala Glu Arg Ala Pro Glu Ala Pro Gln Gly Ala Gly Glu Val Gly 
1               5                   10                  15      


Leu Glu Gln Trp Leu Glu Arg Ser Leu Glu Gln Val Asn Arg Glu Ala 
            20                  25                  30          


Gln Leu His Phe His Pro Glu Phe Leu Phe Arg Leu Trp Asn Thr Cys 
        35                  40                  45              


Val Glu His Trp His Asp Arg Leu Arg Arg Thr Leu Asn Tyr Ala Lys 
    50                  55                  60                  


Tyr Arg Tyr Leu Leu Leu Met Gln Lys Ala Met Phe Val His Met Gln 
65                  70                  75                  80  


Gln Gly Cys Pro Cys Arg Ser Gly His Ser Arg Gly Pro Pro Pro Pro 
                85                  90                  95      


Gly Leu Ala 
            


<210>  19
<211>  104
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  19

Met Ala Glu Arg Ala Pro Glu Val Pro Thr Gly Ala Gly Glu Ala Glu 
1               5                   10                  15      


Phe Gln Pro Trp Leu Arg Asp Met Leu Glu Lys Val Asn Leu Glu Ala 
            20                  25                  30          


Arg Leu His Phe His Pro Glu Phe Ile Phe Arg Leu Trp Arg Thr Cys 
        35                  40                  45              


Val Glu His Trp His Asp Val His Gln Arg Ser Leu Glu Tyr Ala Ala 
    50                  55                  60                  


Tyr Arg Tyr Leu Leu Leu Met Gln Lys Ala Leu Phe Ile His Cys Gln 
65                  70                  75                  80  


Thr Gly Cys Ser Gln Arg His Gly Pro Asn Pro Arg Ala Val Gly Glu 
                85                  90                  95      


Arg Ile Thr Ile Leu Pro Gly Met 
            100                 


<210>  20
<211>  140
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  20

Met Ala Ser Gly Gly Trp Leu Pro Pro Val Gly Gly Asp Pro Pro Lys 
1               5                   10                  15      


Asp Pro Pro Lys Asn Pro Arg Glu Glu Ile Pro Gly Trp Leu Glu Thr 
            20                  25                  30          


Trp Asp Leu Pro Arg Glu Pro Phe Asp Glu Trp Leu Arg Asp Met Leu 
        35                  40                  45              


Gln Asp Leu Asn Ser Glu Ala Gln Cys His Phe Pro Arg Asn Leu Leu 
    50                  55                  60                  


Phe Arg Leu Trp Trp Asn Ile Val Glu Glu Pro Ala Ile Asp His Gly 
65                  70                  75                  80  


Gln Thr Arg Leu Glu Gly Trp Tyr Lys Tyr Cys Arg Ile Leu Gln Lys 
                85                  90                  95      


Ala Leu Phe Val His Met Lys Gly Arg Cys Cys Lys Pro Lys Thr His 
            100                 105                 110         


Pro Ala Tyr Gly Pro Gly Ala Gly Gly Pro Pro Pro Gly Leu Gly Gly 
        115                 120                 125             


Ala Ser Gly Gly Ala Ala Ser Ala Ala Pro Gly Leu 
    130                 135                 140 


<210>  21
<211>  114
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  21

Met Ser Arg Gln Arg Gln Gln Arg Ser Pro Glu Arg Pro Pro Glu Asp 
1               5                   10                  15      


Phe Gly Pro Pro Arg Glu Pro Trp Ala Gln Trp Leu Ala Asp Thr Met 
            20                  25                  30          


Glu Glu Ile Lys Glu Glu Ala Arg Arg His Phe Pro Glu Ala Ile Leu 
        35                  40                  45              


Ala Gln Val Ser Glu Tyr Cys Val Ser Ser Thr Gly Ser Glu Glu Glu 
    50                  55                  60                  


Ala Cys Met Arg Phe Ile Thr Leu Val Asn Arg Ala Leu Tyr Leu His 
65                  70                  75                  80  


Leu Pro Gln Cys Pro Ser Tyr Ala Ala Ala Arg Ala Gly Thr Ala His 
                85                  90                  95      


Pro Thr Glu Ala Ala Pro Arg Pro Thr Gly Arg Asp Ile Gln Arg Gly 
            100                 105                 110         


His Tyr 
        


