                         SEQUENCE LISTING

<110>  ULTRAHUMAN THIRTEEN LIMITED
 
<120>  ERBB3 BINDING AGENTS

<130>  ULTH-001/01WO 332956-2002

<150>  GB 1804094.9
<151>  2018-03-14

<160>  263   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Gly or any other amino acid

<400>  1

Gly Phe Thr Phe Ser Asp Tyr Xaa Met Ser 
1               5                   10  


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Gly or any other amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Thr or a conservative substitution of Thr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Tyr or any other amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Thr or any other amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is Pro or any other amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Asn or a conservative substitution of Asn

<400>  2

Val Ser Thr Ile Ser Asp Xaa Gly Xaa Xaa Xaa Tyr Tyr Xaa Asp Xaa 
1               5                   10                  15      


Val Lys Gly 
            


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Glu or any other amino acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Trp or any other amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Tyr or any other amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Phe or any other amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Tyr or any other amino acid

<400>  3

Xaa Xaa Gly Asp Xaa Asp Gly Xaa Asp Xaa 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24C05 murine/humanized antibody HCDR1

<400>  4

Gly Phe Thr Phe Ser Asp Tyr Ala Met Ser 
1               5                   10  


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24C05 murine/humanized antibody HCDR2

<400>  5

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24C05 murine/humanized antibody HCDR3

<400>  6

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Glu or any other amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Gly or a conservative substitution of Gly

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Ser or a conservative substitution of Ser

<400>  7

Arg Ala Ser Gln Xaa Ile Ser Xaa Tyr Leu Xaa 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ala or any other amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Thr or a conservative substitution of Thr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Asp any other amino acid

<400>  8

Xaa Ala Ser Xaa Leu Xaa Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Leu or any other amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Tyr or any other amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Asp or any other amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Tyr or any other amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Pro or any other amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Tyr or any other amino acid

<400>  9

Xaa Gln Xaa Xaa Ser Xaa Xaa Xaa Thr 
1               5                   


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24C05 murine/humanized antibody LCDR1

<400>  10

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24C05 murine/humanized antibody LCDR2

<400>  11

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24C05 murine/humanized antibody LCDR3

<400>  12

Leu Gln Tyr Asp Ser Tyr Pro Tyr Thr 
1               5                   


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  13

Gly Phe Thr Phe Ser Asp Tyr Gly Met Ser 
1               5                   10  


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  14

Val Ser Thr Ile Ser Asp Ser Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  15

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Phe 
1               5                   10  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  16

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2

<400>  17

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  18

Leu Gln Tyr Asp Ser Thr Pro Leu Thr 
1               5                   


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  19

Val Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  20

Glu Leu Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  21

Arg Ala Ser Gln Glu Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2

<400>  22

Ala Ala Ser Ser Leu Asp Ser 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  23

Leu Gln Tyr Asp Ser Thr Pro Tyr Thr 
1               5                   


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  24

Gly Phe Thr Phe Ser Asp Tyr Ser Met Ser 
1               5                   10  


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  25

Val Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2

<400>  26

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  27

Glu Trp Gly Asp Tyr Asp Gly Phe Asp His 
1               5                   10  


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  28

Val Ser Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  29

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Glu 
1               5                   10  


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  30

Arg Ala Ser Gln Ser Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  31

Val Ser Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion consensus
       LCDR1

<400>  32

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion consensus
       LCDR2

<400>  33

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion consensus
       LCDR3

<400>  34

Leu Gln Tyr Asp Ser Tyr Pro Tyr Thr 
1               5                   


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion consensus
       HCDR1

<400>  35

Gly Phe Thr Phe Ser Asp Tyr Ala Met Ser 
1               5                   10  


<210>  36
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion consensus
       HCDR2

<400>  36

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion consensus
       HCDR3

<400>  37

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Glu, Gly, His, Asn, Arg, Ser, Thr, Gln or Val

<400>  38

Gly Phe Thr Phe Ser Asp Tyr Xaa Met Ser 
1               5                   10  


<210>  39
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Gly, Ser or Asp

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Thr or Ser

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Tyr or Thr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Thr or Ile

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is Pro or Ala

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Asn or Ser

<400>  39

Val Ser Thr Ile Ser Asp Xaa Gly Xaa Xaa Xaa Tyr Tyr Xaa Asp Xaa 
1               5                   10                  15      


Val Lys Gly 
            


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Glu or Met

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Trp, Phe, Leu, Met, Gln or Tyr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Tyr, Ala, Asp, Glu, His, Leu, Met, Asn, Gln, Ser, Thr or 
       Trp

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Phe, Ile, Leu, Trp or Tyr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Tyr, Ala, Asp, Glu, Phe, His, Ile, Lys, Leu, Met, Asn, 
       Gln, Arg, Ser, Val or Trp

<400>  40

Xaa Xaa Gly Asp Xaa Asp Gly Xaa Asp Xaa 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Gly or Ser

<400>  41

Gly Phe Thr Phe Ser Asp Tyr Xaa Met Ser 
1               5                   10  


<210>  42
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Gly or Ser

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Tyr or Thr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Thr or Ile

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is Pro or Ala

<400>  42

Val Ser Thr Ile Ser Asp Xaa Gly Ser Xaa Xaa Tyr Tyr Xaa Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Trp, Leu or Tyr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Tyr, Glu, Phe, His or Asn

<400>  43

Glu Xaa Gly Asp Tyr Asp Gly Phe Asp Xaa 
1               5                   10  


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Glu, Ser, Ile or Asn

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Gly or Ser

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Ser or Asn

<400>  44

Arg Ala Ser Gln Xaa Ile Ser Xaa Tyr Leu Xaa 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ala or Glu

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Thr, Ser or Asn

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Asp, His, Lys or Gln

<400>  45

Xaa Ala Ser Xaa Leu Xaa Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Leu or Gln

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Tyr or Ser

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Asp or Tyr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Tyr or Thr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Pro or His

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Tyr or Leu

<400>  46

Xaa Gln Xaa Xaa Ser Xaa Xaa Xaa Thr 
1               5                   


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Glu or Ser

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Gly or Ser

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Ser or Asn

<400>  47

Arg Ala Ser Gln Xaa Ile Ser Xaa Tyr Leu Xaa 
1               5                   10      


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Thr or Ser

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Asp or Gln

<400>  48

Ala Ala Ser Xaa Leu Xaa Ser 
1               5           


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Asp or Tyr

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Tyr or Leu

<400>  49

Leu Gln Tyr Xaa Ser Thr Pro Xaa Thr 
1               5                   


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  50

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  51

Glu Tyr Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  52

Arg Ala Ser Gln Ile Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  53

Leu Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  54
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  54

Val Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  55

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Asn 
1               5                   10  


<210>  56
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  56

Val Ser Thr Ile Ser Asp Ser Gly Thr Thr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  57
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  57

Val Ser Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  58
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  58

Val Ser Thr Ile Ser Asp Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  59
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  59

Gly Phe Thr Phe Ser Asp Tyr Ala Met Ser 
1               5                   10  


<210>  60
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  60

Asp Tyr Ala Met Ser 
1               5   


<210>  61
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  61

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  62
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  62

Gly Phe Thr Phe Ser Asp Tyr Ala 
1               5               


<210>  63
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  63

Ala Ser Gly Phe Thr Phe Ser Asp Tyr Ala Met Ser 
1               5                   10          


<210>  64
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  64

Ser Asp Tyr Ala Met Ser 
1               5       


<210>  65
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  65

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  66
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  66

Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Asn Val Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  67

Ser Asp Gly Gly Thr Tyr 
1               5       


<210>  68
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  68

Ile Ser Asp Gly Gly Thr Tyr Thr 
1               5               


<210>  69
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  69

Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Asn Val Lys Gly 
1               5                   10                  15      


<210>  70
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  70

Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr 
1               5                   10  


<210>  71
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  71

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr 
1               5                   10          


<210>  72
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  72

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  73
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  73

Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10          


<210>  74
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  74

Glu Trp Gly Asp Tyr Asp Gly Phe Asp 
1               5                   


<210>  75
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  75

Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp 
1               5                   10      


<210>  76
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  76

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  77
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  77

Gln Glu Ile Ser Gly Tyr 
1               5       


<210>  78
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  78

Ala Ser Gln Glu Ile Ser Gly Tyr 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  79

Ile Ser Gly Tyr Leu Ser Trp Tyr 
1               5               


<210>  80
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  80

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  81
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  81

Leu Leu Ile Tyr Ala Ala Ser Thr Leu Asp 
1               5                   10  


<210>  82
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  82

Leu Gln Tyr Asp Ser Tyr Pro Tyr Thr 
1               5                   


<210>  83
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  83

Tyr Asp Ser Tyr Pro Tyr 
1               5       


<210>  84
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  84

Leu Gln Tyr Asp Ser Tyr Pro Tyr 
1               5               


<210>  85
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h24C05-VH IGHV3-11

<400>  85

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  86
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH graft IGHV3-11

<400>  86

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  87
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h24C05-VL IGKV1-16

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  88
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL graft IGKV1-39

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  89

Arg Ala Ser Gln Ser Ile Ser Gly Tyr Leu Asn 
1               5                   10      


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  90

Arg Ala Ser Gln Glu Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  91

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Asn 
1               5                   10      


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  92

Arg Ala Ser Gln Asn Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2

<400>  93

Ala Ala Ser Asn Leu Gln Ser 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2

<400>  94

Ala Ala Ser Ser Leu His Ser 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2

<400>  95

Glu Ala Ser Ser Leu Asp Ser 
1               5           


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2

<400>  96

Ala Ala Ser Ser Leu Lys Ser 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2

<400>  97

Glu Ala Ser Ser Leu Gln Ser 
1               5           


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  98

Leu Gln Tyr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  99

Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  100

Leu Gln Tyr Asp Ser Tyr Pro Leu Thr 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  101

Gln Gln Tyr Asp Ser Thr Pro Tyr Thr 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  102

Leu Gln Ser Asp Ser Thr Pro Tyr Thr 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  103

Leu Gln Ser Asp Ser Thr Pro Leu Thr 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  104

Gln Gln Tyr Asp Ser Tyr Pro Leu Thr 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  105

Leu Gln Tyr Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  106

Leu Gln Tyr Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  107

Gln Gln Tyr Asp Ser Thr Pro Leu Thr 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  108

Leu Gln Tyr Asp Ser Tyr His Leu Thr 
1               5                   


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  109

Gly Phe Thr Phe Ser Asp Tyr Ala Met Ser 
1               5                   10  


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  110

Gly Phe Thr Phe Ser Asp Tyr Glu Met Ser 
1               5                   10  


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  111

Gly Phe Thr Phe Ser Asp Tyr His Met Ser 
1               5                   10  


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  112

Gly Phe Thr Phe Ser Asp Tyr Asn Met Ser 
1               5                   10  


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  113

Gly Phe Thr Phe Ser Asp Tyr Gln Met Ser 
1               5                   10  


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  114

Gly Phe Thr Phe Ser Asp Tyr Arg Met Ser 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  115

Gly Phe Thr Phe Ser Asp Tyr Thr Met Ser 
1               5                   10  


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR1

<400>  116

Gly Phe Thr Phe Ser Asp Tyr Val Met Ser 
1               5                   10  


<210>  117
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  117

Val Gly Thr Ile Ser Asp Gly Gly Thr Thr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  118
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  118

Val Ser Thr Ile Ser Asp Asp Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  119
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  119

Val Ser Thr Ile Ser Asp Gly Gly Ser Thr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  120
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  120

Val Ser Thr Ile Ser Asp Gly Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  121
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  121

Val Ser Thr Ile Ser Asp Gly Gly Ser Thr Ile Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  122
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  122

Val Ser Thr Ile Ser Asp Gly Gly Ser Thr Ile Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  123
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  123

Val Ser Thr Ile Ser Asp Gly Gly Ser Thr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  124
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  124

Val Ser Thr Ile Ser Asp Gly Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  125
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  125

Val Ser Thr Ile Ser Asp Gly Gly Ser Thr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  126
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  126

Val Ser Thr Ile Ser Asp Gly Gly Ser Thr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  127
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  127

Val Ser Thr Ile Ser Asp Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  128
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  128

Val Ser Thr Ile Ser Asp Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  129
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  129

Val Ser Thr Ile Ser Asp Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  130
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  130

Val Ser Thr Ile Ser Asp Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  131
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  131

Val Ser Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  132
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  132

Val Ser Thr Ile Ser Asp Gly Gly Thr Thr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  133
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  133

Val Ser Thr Ile Ser Asp Gly Gly Thr Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  134
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  134

Val Ser Thr Ile Ser Asp Gly Gly Thr Thr Ile Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  135
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  135

Val Ser Thr Ile Ser Asp Gly Gly Thr Thr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  136
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  136

Val Ser Thr Ile Ser Asp Gly Gly Thr Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  137
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  137

Val Ser Thr Ile Ser Asp Gly Gly Thr Thr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  138
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  138

Val Ser Thr Ile Ser Asp Gly Gly Thr Thr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  139
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  139

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  140
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  140

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  141
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  141

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  142
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  142

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  143
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  143

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  144
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  144

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  145
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  145

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  146
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  146

Val Ser Thr Ile Ser Asp Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  147
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  147

Val Ser Thr Ile Ser Asp Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  148
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  148

Val Ser Thr Ile Ser Asp Ser Gly Ser Thr Ile Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  149
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  149

Val Ser Thr Ile Ser Asp Ser Gly Ser Thr Ile Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  150
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  150

Val Ser Thr Ile Ser Asp Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  151
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  151

Val Ser Thr Ile Ser Asp Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  152
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  152

Val Ser Thr Ile Ser Asp Ser Gly Ser Thr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  153
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  153

Val Ser Thr Ile Ser Asp Ser Gly Ser Thr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  154
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  154

Val Ser Thr Ile Ser Asp Ser Gly Ser Tyr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  155
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  155

Val Ser Thr Ile Ser Asp Ser Gly Ser Tyr Ile Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  156
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  156

Val Ser Thr Ile Ser Asp Ser Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  157
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  157

Val Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  158
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  158

Val Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  159
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  159

Val Ser Thr Ile Ser Asp Ser Gly Thr Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  160
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  160

Val Ser Thr Ile Ser Asp Ser Gly Thr Thr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  161
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  161

Val Ser Thr Ile Ser Asp Ser Gly Thr Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  162
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  162

Val Ser Thr Ile Ser Asp Ser Gly Thr Thr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  163
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  163

Val Ser Thr Ile Ser Asp Ser Gly Thr Thr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  164
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  164

Val Ser Thr Ile Ser Asp Ser Gly Thr Tyr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  165
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  165

Val Ser Thr Ile Ser Asp Ser Gly Thr Tyr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  166
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  166

Val Ser Thr Ile Ser Asp Ser Gly Thr Tyr Ile Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  167
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  167

Val Ser Thr Ile Ser Asp Ser Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  168
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  168

Val Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  169
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  169

Val Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  170
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  170

Val Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Pro Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  171
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  171

Val Ser Thr Ile Ser Asn Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  172
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  172

Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  173
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  173

Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  174
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  174

Val Ser Thr Ile Ser Ser Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  175
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  175

Val Ser Thr Ile Ser Ser Ser Gly Thr Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  176
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  176

Val Ser Thr Ile Ser Ser Ser Gly Thr Tyr Ile Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  177
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  177

Val Ser Tyr Ile Ser Asp Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  178
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  178

Val Ser Tyr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Asn 
1               5                   10                  15      


Val Lys Gly 
            


<210>  179
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  179

Val Ser Tyr Ile Ser Asp Gly Gly Thr Thr Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  180
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR2

<400>  180

Val Ser Tyr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  181

Glu Phe Gly Asp Tyr Asp Gly Phe Asp Phe 
1               5                   10  


<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  182

Glu Phe Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  183
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  183

Glu Leu Gly Asp Tyr Asp Gly Trp Asp Tyr 
1               5                   10  


<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  184

Glu Met Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  185
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  185

Glu Gln Gly Asp Tyr Asp Gly Phe Asp Ile 
1               5                   10  


<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  186

Glu Trp Gly Asp Ala Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  187
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  187

Glu Trp Gly Asp Asp Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  188
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  188

Glu Trp Gly Asp Glu Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  189
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  189

Glu Trp Gly Asp His Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  190

Glu Trp Gly Asp Leu Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  191
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  191

Glu Trp Gly Asp Met Asp Gly Phe Asp Arg 
1               5                   10  


<210>  192
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  192

Glu Trp Gly Asp Met Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  193
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  193

Glu Trp Gly Asp Asn Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  194
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  194

Glu Trp Gly Asp Gln Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  195
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  195

Glu Trp Gly Asp Ser Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  196

Glu Trp Gly Asp Thr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  197
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  197

Glu Trp Gly Asp Trp Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  198
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  198

Glu Trp Gly Asp Tyr Asp Gly Cys Asp Tyr 
1               5                   10  


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  199

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Ala 
1               5                   10  


<210>  200
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  200

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Asp 
1               5                   10  


<210>  201
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  201

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Ile 
1               5                   10  


<210>  202
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  202

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Lys 
1               5                   10  


<210>  203
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  203

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Leu 
1               5                   10  


<210>  204
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  204

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Met 
1               5                   10  


<210>  205
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  205

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Gln 
1               5                   10  


<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  206

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Arg 
1               5                   10  


<210>  207
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  207

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Ser 
1               5                   10  


<210>  208
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  208

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Val 
1               5                   10  


<210>  209
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  209

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Trp 
1               5                   10  


<210>  210
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  210

Glu Trp Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  211
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  211

Glu Trp Gly Asp Tyr Asp Gly Phe His Tyr 
1               5                   10  


<210>  212
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  212

Glu Trp Gly Asp Tyr Asp Gly Ile Asp Tyr 
1               5                   10  


<210>  213
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  213

Glu Trp Gly Asp Tyr Asp Gly Leu Asp Tyr 
1               5                   10  


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  214

Glu Trp Gly Asp Tyr Asp Gly Trp Asp Tyr 
1               5                   10  


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  215

Glu Trp Gly Asp Tyr Asp Gly Tyr Asp Tyr 
1               5                   10  


<210>  216
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion HCDR3

<400>  216

Met Trp Gly Asp Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  217
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI1 VL

<400>  217

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  218
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI2 VL

<400>  218

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  219
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI3 VL

<400>  219

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  220
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI4 VL

<400>  220

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  221
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI5 VL

<400>  221

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  222
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI6 VL

<400>  222

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  223
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI7 VL

<400>  223

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  224
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI8 VL

<400>  224

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  225
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI9 VL

<400>  225

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  226
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI10 VL

<400>  226

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ala 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  227
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI11 VL

<400>  227

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ala Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ala 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  228
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI1 VH

<400>  228

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Asp Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  229
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI2 VH

<400>  229

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Asp Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  230
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI3 VH

<400>  230

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Asp Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  231
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI4 VH

<400>  231

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Asp Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  232
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI5 VH

<400>  232

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  233
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI6 VH

<400>  233

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  234
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI7 VH

<400>  234

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  235
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI8 VH

<400>  235

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  236
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI9 VH

<400>  236

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  237
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI10 VH

<400>  237

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Asp Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  238
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15G11-DI11 VH

<400>  238

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Asp Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  239
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  239

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  240
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  240

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  241
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  241

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  242
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  242

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  243
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  243

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  244
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  244

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  245
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  245

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 


<210>  246
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  247
<211>  1342
<212>  PRT
<213>  Macaca mulatta

<400>  247

Met Arg Ala Asn Gly Ala Leu Gln Val Leu Gly Leu Leu Phe Asn Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Lys Asp Ile Val Arg Asp Gln Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Leu Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Pro Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met Tyr Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Ile Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ala  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Trp Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Thr Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro Arg  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Val 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Gly Gly Ser  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


His Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  248
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  248

Arg Asp Glu Leu Thr 
1               5   


<210>  249
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  249

Arg Glu Glu Met 
1               


<210>  250
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  epitope-ablating variant peptide

<400>  250

Tyr Ser Met Ser Trp Ile Arg Gln Ala 
1               5                   


<210>  251
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  epitope-ablating variant peptide

<400>  251

Tyr Gly Met Ser Trp Val Arg Gln Ala 
1               5                   


<210>  252
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HAF epitope

<400>  252

Ile Tyr Ala Ala Ser Thr Leu Asp Ser 
1               5                   


<210>  253
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody 15G11 heavy chain variable (VH) region

<400>  253

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Asp Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  254
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody 15G11 light chain variable (VL) region

<400>  254

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  255
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody 16B09 heavy chain variable (VH) region

<400>  255

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asp Ser Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Gly Asp Tyr Asp Gly Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  256
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody 16B09 light chain variable (VL) region

<400>  256

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  257
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  portion of anti-ERBB3 15G11 antibody VH region


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Tyr, Ala, Gly, His, Ser or any non-hydrophobic amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Gly, Ala, Ser, Trp or Tyr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Met, Ala, Phe, Ser, Val, Trp or Tyr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Ser, Gly, Asn or Tyr

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Ile or Val

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is Ala, Pro or Thr

<400>  257

Phe Ser Asp Xaa Xaa Xaa Xaa Trp Xaa Arg Gln Xaa Pro Gly Lys Gly 
1               5                   10                  15      


<210>  258
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  portion of anti-ERBB3 15G11 antibody VL region


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Ile, Ala, Gly, Ser or any non-hydrophobic amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Ser or Asp

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Ser, Asp, Lys or Thr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Tyr, Ala, Arg, Ser or Trp

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Ser, Ala, Gly, His, Asn or Tyr

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is Gln or Arg

<400>  258

Ser Gln Glu Xaa Xaa Xaa Xaa Leu Xaa Trp Tyr Xaa Gln Lys Pro Gly 
1               5                   10                  15      


<210>  259
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  portion of anti-ERBB3 15G11 antibody VL region


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Ala or Asp

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Ala or Asp

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is Ser, Asp, Pro or Thr

<400>  259

Lys Leu Leu Ile Tyr Xaa Xaa Ser Ser Leu Asp Xaa Gly Val Pro 
1               5                   10                  15  


<210>  260
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  portion of anti-ERBB3 15G11 antibody VL region


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Leu, Ala, Gly, His, Gln, Ser or any non-hydrophobic 
       amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Gln, Ala, His, Ser or Thr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Tyr, Ala, Gly, His, Ser or Trp

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Thr, Ala, Gly, Asn, Ser or Tyr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Pro, Asp, Ser or Thr

<400>  260

Tyr Tyr Cys Xaa Xaa Xaa Asp Ser Xaa Xaa Tyr Thr Phe Gly Gly 
1               5                   10                  15  


<210>  261
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR1

<400>  261

Arg Ala Ser Gln Glu Ile Ser Thr Tyr Leu Ser 
1               5                   10      


<210>  262
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR3

<400>  262

Leu Gln Tyr Asp Ser Ser Pro Leu Thr 
1               5                   


<210>  263
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ERBB3 antibody molecule or antigen-binding portion LCDR2

<400>  263

Ala Ala Ser Ser Leu Asp Thr 
1               5           