                         SEQUENCE LISTING

<110>  OSE IMMUNOTHERAPEUTICS
 
<120>  Use of anti-human SIRPa v1 antibodies and method for producing 
       anti-SIRPa v1 antibodies

<130>  B13060A/AD/HLQ

<140>  PCT/EPXX XXX XXX
<141>  2019-03-13


<150>  EP18305271.1
<151>  2018-03-13

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope SIRPa v1

<400>  1

Lys Gly Ser Pro Asp Asp Val 
1               5           


<210>  2
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope SIRPa v2

<400>  2

Lys Gly Ser Pro Asp Thr 
1               5       


<210>  3
<211>  504
<212>  PRT
<213>  artificial sequence

<220>
<223>  SIRPa v1 (with SP)

<400>  3

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  4
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope SIRPa v1 long version

<400>  4

Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linear epitope SIRPa v1 /1

<400>  5

Ser Leu Ile Pro Val Gly Pro 
1               5           


<210>  6
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linear epitope SIRPa v1 /2

<400>  6

Gly Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His 
1               5                   10          


<210>  7
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Conformational epitope SIRPa v1 /1

<400>  7

Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg 
1               5                   10              


<210>  8
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Conformational epitope SIRPa v1 /2

<400>  8

Arg Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
1               5                   10      


<210>  9
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR1

<400>  9

Ser Tyr Trp Val His 
1               5   


<210>  10
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR2 1

<400>  10

Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR2 2

<400>  11

Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


<210>  12
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR3 1

<400>  12

Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR3 2

<400>  13

Gly Gly Thr Gly Thr Leu Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR3 3

<400>  14

Gly Gly Thr Gly Thr Met Ala Tyr Phe Ala Tyr 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR3 4

<400>  15

Gly Gly Thr Gly Thr Leu Ala Tyr Phe Ala Tyr 
1               5                   10      


<210>  16
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain variable domain /1

<400>  16

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Phe Gln Gly 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain variable domain /2

<400>  17

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Tyr Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  18
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain variable domain /1

<400>  18

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Thr Gly Thr Leu Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain variable domain /2

<400>  19

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Thr Gly Thr Met Ala Tyr Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain variable domain /3

<400>  20

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Thr Gly Thr Leu Ala Tyr Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  21
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain variable domain /4

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain variable domain /5

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain variable domain /6

<400>  23

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  474
<212>  PRT
<213>  artificial sequence

<220>
<223>  SIRPa V1 (without SP)

<400>  24

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu 
            340                 345                 350         


Leu Val Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln 
        355                 360                 365             


Lys Lys Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu 
    370                 375                 380                 


Lys Asn Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala 
385                 390                 395                 400 


Asp Leu Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu 
                405                 410                 415     


Pro Asn Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro 
            420                 425                 430         


Ala Ser Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu 
        435                 440                 445             


Asn Arg Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser 
    450                 455                 460                 


Glu Tyr Ala Ser Val Gln Val Pro Arg Lys 
465                 470                 


<210>  25
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope SIRPa v1 right

<400>  25

Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
1               5                   10                  15      


<210>  26
<211>  4201
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA complete SIRPa v1

<400>  26
tccggcccgc acccaccccc aagaggggcc ttcagctttg gggctcagag gcacgacctc       60

ctggggaggg ttaaaaggca gacgcccccc cgccccccgc gcccccgcgc cccgactcct      120

tcgccgcctc cagcctctcg ccagtgggaa gcggggagca gccgcgcggc cggagtccgg      180

aggcgagggg aggtcggccg caacttcccc ggtccacctt aagaggacga tgtagccagc      240

tcgcagcgct gaccttagaa aaacaagttt gcgcaaagtg gagcggggac ccggcctctg      300

ggcagccccg gcggcgcttc cagtgccttc cagccctcgc gggcggcgca gccgcggccc      360

atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc      420

gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac      480

aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg      540

atccctgtgg ggcccatcca gtggttcaga ggagctggac caggccggga attaatctac      600

aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac      660

aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac      720

tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact      780

gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc      840

acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc      900

accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc      960

gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag     1020

gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt     1080

cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa     1140

cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc     1200

cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca     1260

accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta     1320

tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg     1380

gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc     1440

gccgctgaga acactggatc taatgaacgg aacatctata ttgtggtggg tgtggtgtgc     1500

accttgctgg tggccctact gatggcggcc ctctacctcg tccgaatcag acagaagaaa     1560

gcccagggct ccacttcttc tacaaggttg catgagcccg agaagaatgc cagagaaata     1620

acacaggaca caaatgatat cacatatgca gacctgaacc tgcccaaggg gaagaagcct     1680

gctccccagg ctgcggagcc caacaaccac acggagtatg ccagcattca gaccagcccg     1740

cagcccgcgt cggaggacac cctcacctat gctgacctgg acatggtcca cctcaaccgg     1800

acccccaagc agccggcccc caagcctgag ccgtccttct cagagtacgc cagcgtccag     1860

gtcccgagga agtgaatggg accgtggttt gctctagcac ccatctctac gcgctttctt     1920

gtcccacagg gagccgccgt gatgagcaca gccaacccag ttcccggagg gctggggcgg     1980

tgcaggctct gggacccagg ggccagggtg gctcttctct ccccacccct ccttggctct     2040

ccagcacttc ctgggcagcc acggccccct ccccccacat tgccacatac ctggaggctg     2100

acgttgccaa accagccagg gaaccaacct gggaagtggc cagaactgcc tggggtccaa     2160

gaactcttgt gcctccgtcc atcaccatgt gggttttgaa gaccctcgac tgcctccccg     2220

atgctccgaa gcctgatctt ccagggtggg gaggagaaaa tcccacctcc cctgacctcc     2280

accacctcca ccaccaccac caccaccacc accaccacta ccaccaccac ccaactgggg     2340

ctagagtggg gaagatttcc cctttagatc aaactgcccc ttccatggaa aagctggaaa     2400

aaaactctgg aacccatatc caggcttggt gaggttgctg ccaacagtcc tggcctcccc     2460

catccctagg ctaaagagcc atgagtcctg gaggaggaga ggacccctcc caaaggactg     2520

gagacaaaac cctctgcttc cttgggtccc tccaagactc cctggggccc aactgtgttg     2580

ctccacccgg acccatctct cccttctaga cctgagcttg cccctccagc tagcactaag     2640

caacatctcg ctgtggacgc ctgtaaatta ctgagaaatg tgaaacgtgc aatcttgaaa     2700

ctgaggtgtt agaaaacttg atctgtggtg ttttgttttg ttttttttct taaaacaaca     2760

gcaacgtgat cttggctgtc tgtcatgtgt tgaagtccat ggttgggtct tgtgaagtct     2820

gaggtttaac agtttgttgt cctggaggga ttttcttaca gcgaagactt gagttcctcc     2880

aagtcccaga accccaagaa tgggcaagaa ggatcaggtc agccactccc tggagacaca     2940

gccttctggc tgggactgac ttggccatgt tctcagctga gccacgcggc tggtagtgca     3000

gccttctgtg accccgctgt ggtaagtcca gcctgcccag ggctgctgag ggctgcctct     3060

tgacagtgca gtcttatcga gacccaatgc ctcagtctgc tcatccgtaa agtggggata     3120

gtgaagatga cacccctccc caccacctct cataagcact ttaggaacac acagagggta     3180

gggatagtgg ccctggccgt ctatcctacc cctttagtga ccgcccccat cccggctttc     3240

tgagctgatc cttgaagaag aaatcttcca tttctgctct caaaccctac tgggatcaaa     3300

ctggaataaa ttgaagacag ccagggggat ggtgcagctg tgaagctcgg gctgattccc     3360

cctctgtccc agaaggttgg ccagagggtg tgacccagtt accctttaac ccccaccctt     3420

ccagtcgggt gtgagggcct gaccgggccc agggcaagca gatgtcgcaa gccctattta     3480

ttcagtcttc actataactc ttagagttga gacgctaatg ttcatgactc ctggccttgg     3540

gatgcccaag ggatttctgg ctcaggctgt aaaagtagct gagccatcct gcccattcct     3600

ggaggtccta caggtgaaac tgcaggagct cagcatagac ccagctctct gggggatggt     3660

cacctggtga tttcaatgat ggcatccagg aattagctga gccaacagac catgtggaca     3720

gctttggcca gagctcccgt gtggcatctg ggagccacag tgacccagcc acctggctca     3780

ggctagttcc aaattccaaa agattggctt gtaaaccttc gtctccctct cttttaccca     3840

gagacagcac atacgtgtgc acacgcatgc acacacacat tcagtatttt aaaagaatgt     3900

tttcttggtg ccattttcat tttattttat tttttaattc ttggaggggg aaataaggga     3960

ataaggccaa ggaagatgta tagctttagc tttagcctgg caacctggag aatccacata     4020

ccttgtgtat tgaaccccag gaaaaggaag aggtcgaacc aaccctgcgg aaggagcatg     4080

gtttcaggag tttattttaa gactgctggg aaggaaacag gccccatttt gtatatagtt     4140

gcaacttaaa ctttttggct tgcaaaatat ttttgtaata aagatttctg ggtaataatg     4200

a                                                                     4201


<210>  27
<211>  357
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA exon 3 SIRPa v1

<400>  27
gagtggcggg tgaggaggag ctgcaggtga ttcagcctga caagtccgtg ttggttgcag       60

ctggagagac agccactctg cgctgcactg cgacctctct gatccctgtg gggcccatcc      120

agtggttcag aggagctgga ccaggccggg aattaatcta caatcaaaaa gaaggccact      180

tcccccgggt aacaactgtt tcagacctca caaagagaaa caacatggac ttttccatcc      240

gcatcggtaa catcacccca gcagatgccg gcacctacta ctgtgtgaag ttccggaaag      300

ggagccccga tgacgtggag tttaagtctg gagcaggcac tgagctgtct gtgcgcg         357


<210>  28
<211>  503
<212>  PRT
<213>  artificial sequence

<220>
<223>  SIRPa v2 (with SP)

<400>  28

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly 
        35                  40                  45              


Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Ser 
                85                  90                  95      


Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
    130                 135                 140                 


Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr 
145                 150                 155                 160 


Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 
                165                 170                 175     


Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 
            180                 185                 190         


Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile 
        195                 200                 205             


His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln 
    210                 215                 220                 


Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 
225                 230                 235                 240 


Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu 
                245                 250                 255     


Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys 
            260                 265                 270         


Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu 
        275                 280                 285             


Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn 
    290                 295                 300                 


Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser 
305                 310                 315                 320 


Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly 
                325                 330                 335     


Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro 
            340                 345                 350         


Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn Glu 
        355                 360                 365             


Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val Ala 
    370                 375                 380                 


Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys Ala 
385                 390                 395                 400 


Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn Ala 
                405                 410                 415     


Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu Asn 
            420                 425                 430         


Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn Asn 
        435                 440                 445             


His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser Glu 
    450                 455                 460                 


Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg Thr 
465                 470                 475                 480 


Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr Ala 
                485                 490                 495     


Ser Val Gln Val Pro Arg Lys 
            500             


<210>  29
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope SIRPa v2 long version

<400>  29

Lys Phe Arg Lys Gly Ser Pro Asp Thr Glu 
1               5                   10  


<210>  30
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope SIRPa v2 right

<400>  30

Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
1               5                   10                  


<210>  31
<211>  355
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA exon 3 SIRPa v2

<400>  31
gagtggcggg tgaggaggag ctgcaggtga ttcagcctga caagtccgta tcagttgcag       60

ctggagagtc ggccattctg cactgcactg tgacctccct gatccctgtg gggcccatcc      120

agtggttcag aggagctgga ccagcccggg aattaatcta caatcaaaaa gaaggccact      180

tcccccgggt aacaactgtt tcagagtcca caaagagaga aaacatggac ttttccatca      240

gcatcagtaa catcacccca gcagatgccg gcacctacta ctgtgtgaag ttccggaaag      300

ggagccctga cacggagttt aagtctggag caggcactga gctgtctgtg cgtgc           355


<210>  32
<211>  180
<212>  PRT
<213>  artificial sequence

<220>
<223>  SIRPa human variant 1

<400>  32

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile 
            180 


<210>  33
<211>  179
<212>  PRT
<213>  artificial sequence

<220>
<223>  SIRPa human variant 2

<400>  33

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
    130                 135                 140                 


Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr 
145                 150                 155                 160 


Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 
                165                 170                 175     


Arg Asp Ile 
            


<210>  34
<211>  179
<212>  PRT
<213>  artificial sequence

<220>
<223>  SIRPb human

<400>  34

Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 
1               5                   10                  15      


Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Asp Glu 
            20                  25                  30          


Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu 
        35                  40                  45              


Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro 
    50                  55                  60                  


Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr 
                85                  90                  95      


Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro 
            100                 105                 110         


Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 
        115                 120                 125             


Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
    130                 135                 140                 


Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Val Arg Ala Thr 
145                 150                 155                 160 


Pro Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 
                165                 170                 175     


Arg Asp Ile 
            


<210>  35
<211>  178
<212>  PRT
<213>  artificial sequence

<220>
<223>  SIRPg human /1

<400>  35

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 
            20                  25                  30          


Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 
        35                  40                  45              


Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 
    50                  55                  60                  


Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 
            100                 105                 110         


Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 
        115                 120                 125             


Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Ala 
    130                 135                 140                 


Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr Pro 
145                 150                 155                 160 


Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 
                165                 170                 175     


Asp Ile 
        


