                         SEQUENCE LISTING

<110>  Roche Diagnostics GmbH
       F. Hoffmann-La Roche AG
 
<120>  Method for affinity maturation of antibodies

<130>  P34730-WO

<150>  EP18161699.6
<151>  2018-03-14

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  297
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ser Asp Ile Glu Glu Val Val Glu Glu Tyr Glu Glu Glu Glu Gln 
1               5                   10                  15      


Glu Glu Ala Ala Val Glu Glu Glu Glu Asp Trp Arg Glu Asp Glu Asp 
            20                  25                  30          


Glu Gln Glu Glu Ala Ala Glu Glu Asp Ala Glu Ala Glu Ala Glu Thr 
        35                  40                  45              


Glu Glu Thr Arg Ala Glu Glu Asp Glu Glu Glu Glu Glu Ala Lys Glu 
    50                  55                  60                  


Ala Glu Asp Gly Pro Met Glu Glu Ser Lys Pro Lys Pro Arg Ser Phe 
65                  70                  75                  80  


Met Pro Asn Leu Val Pro Pro Lys Ile Pro Asp Gly Glu Arg Val Asp 
                85                  90                  95      


Phe Asp Asp Ile His Arg Lys Arg Met Glu Lys Asp Leu Asn Glu Leu 
            100                 105                 110         


Gln Ala Leu Ile Glu Ala His Phe Glu Asn Arg Lys Lys Glu Glu Glu 
        115                 120                 125             


Glu Leu Val Ser Leu Lys Asp Arg Ile Glu Arg Arg Arg Ala Glu Arg 
    130                 135                 140                 


Ala Glu Gln Gln Arg Ile Arg Asn Glu Arg Glu Lys Glu Arg Gln Asn 
145                 150                 155                 160 


Arg Leu Ala Glu Glu Arg Ala Arg Arg Glu Glu Glu Glu Asn Arg Arg 
                165                 170                 175     


Lys Ala Glu Asp Ala Arg Lys Lys Lys Ala Leu Ser Asn Met Met His 
            180                 185                 190         


Phe Gly Gly Tyr Ile Gln Lys Gln Ala Gln Thr Glu Arg Lys Ser Gly 
        195                 200                 205             


Lys Arg Gln Thr Glu Arg Glu Lys Lys Lys Lys Ile Leu Ala Glu Arg 
    210                 215                 220                 


Arg Lys Val Leu Ala Ile Asp His Leu Asn Glu Asp Gln Leu Arg Glu 
225                 230                 235                 240 


Lys Ala Lys Glu Leu Trp Gln Ser Ile Tyr Asn Leu Glu Ala Glu Lys 
                245                 250                 255     


Phe Asp Leu Gln Glu Lys Phe Lys Gln Gln Lys Tyr Glu Ile Asn Val 
            260                 265                 270         


Leu Arg Asn Arg Ile Asn Asp Asn Gln Lys Val Ser Lys Thr Arg Gly 
        275                 280                 285             


Lys Ala Lys Val Thr Gly Arg Trp Lys 
    290                 295         


<210>  2
<211>  15
<212>  PRT
<213>  mus musculus

<400>  2

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Thr Ser Tyr Met Asn 
1               5                   10                  15  


<210>  3
<211>  7
<212>  PRT
<213>  mus musculus

<400>  3

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  4
<211>  9
<212>  PRT
<213>  mus musculus

<400>  4

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  5
<211>  5
<212>  PRT
<213>  mus musculus

<400>  5

Asp Tyr Tyr Met Lys 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Tyr Ile Met Lys 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  mus musculus

<400>  7

Asp Tyr Phe Met Lys 
1               5   


<210>  8
<211>  10
<212>  PRT
<213>  mus musculus

<400>  8

Asp Ile Asn Pro Asn Asn Gly Glu Thr Phe 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  mus musculus

<400>  9

Asp Ile Asn Pro Asn Asn Gly Glu Thr Trp 
1               5                   10  


<210>  10
<211>  5
<212>  PRT
<213>  mus musculus

<400>  10

Arg Val Phe Asp Tyr 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  mus musculus

<400>  11

Arg Tyr Phe Asp Tyr 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  mus musculus

<400>  12

Arg Val Phe Asp Phe 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  mus musculus

<400>  13

Arg Tyr Phe Asp Phe 
1               5   


<210>  14
<211>  24
<212>  PRT
<213>  mus musculus

<400>  14

Met Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys 
            20                  


<210>  15
<211>  15
<212>  PRT
<213>  mus musculus

<400>  15

Trp Phe Gln Gln Lys Ala Gly Gln Pro Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  16
<211>  32
<212>  PRT
<213>  mus musculus

<400>  16

Gly Ile Pro Ala Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Ala 
1               5                   10                  15      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  17
<211>  11
<212>  PRT
<213>  mus musculus

<400>  17

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  18
<211>  31
<212>  PRT
<213>  mus musculus

<400>  18

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30      


<210>  19
<211>  14
<212>  PRT
<213>  mus musculus

<400>  19

Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  20
<211>  39
<212>  PRT
<213>  mus musculus

<400>  20

Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
1               5                   10                  15      


Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Thr 
        35                  


<210>  21
<211>  11
<212>  PRT
<213>  mus musculus

<400>  21

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  22
<211>  219
<212>  PRT
<213>  mus musculus

<400>  22

Met Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr 
            20                  25                  30          


Asp Gly Thr Ser Tyr Met Asn Trp Phe Gln Gln Lys Ala Gly Gln Pro 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Ala Leu Asn Ile 
65                  70                  75                  80  


His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser 
                85                  90                  95      


Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  23
<211>  212
<212>  PRT
<213>  mus musculus

<400>  23

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Ile Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Trp Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Val Phe Asp Phe Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  24
<211>  212
<212>  PRT
<213>  mus musculus

<400>  24

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Phe Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Phe Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  25
<211>  212
<212>  PRT
<213>  mus musculus

<400>  25

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Phe Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Phe Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Tyr Phe Asp Phe Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  26
<211>  212
<212>  PRT
<213>  mus musculus

<400>  26

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Phe Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Trp Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Tyr Phe Asp Phe Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  27
<211>  212
<212>  PRT
<213>  mus musculus

<400>  27

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Phe Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Trp Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  28
<211>  212
<212>  PRT
<213>  mus musculus

<400>  28

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Phe Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Trp Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Val Phe Asp Phe Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  29
<211>  212
<212>  PRT
<213>  mus musculus

<400>  29

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Phe Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Trp Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  30
<211>  212
<212>  PRT
<213>  mus musculus

<400>  30

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Phe Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Phe Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Val Phe Asp Phe Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  31
<211>  212
<212>  PRT
<213>  mus musculus

<400>  31

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Trp Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Val Phe Asp Phe Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  32
<211>  212
<212>  PRT
<213>  mus musculus

<400>  32

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Ile Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Trp Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  33
<211>  210
<212>  PRT
<213>  homo sapiens

<400>  33

Met Ala Asp Gly Ser Ser Asp Ala Ala Arg Glu Pro Arg Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ile Arg Arg Arg Ser Ser Asn Tyr Arg Ala Tyr Ala Thr Glu 
            20                  25                  30          


Pro His Ala Lys Lys Lys Ser Lys Ile Ser Ala Ser Arg Lys Leu Gln 
        35                  40                  45              


Leu Lys Thr Leu Leu Leu Gln Ile Ala Lys Gln Glu Leu Glu Arg Glu 
    50                  55                  60                  


Ala Glu Glu Arg Arg Gly Glu Lys Gly Arg Ala Leu Ser Thr Arg Cys 
65                  70                  75                  80  


Gln Pro Leu Glu Leu Ala Gly Leu Gly Phe Ala Glu Leu Gln Asp Leu 
                85                  90                  95      


Cys Arg Gln Leu His Ala Arg Val Asp Lys Val Asp Glu Glu Arg Tyr 
            100                 105                 110         


Asp Ile Glu Ala Lys Val Thr Lys Asn Ile Thr Glu Ile Ala Asp Leu 
        115                 120                 125             


Thr Gln Lys Ile Phe Asp Leu Arg Gly Lys Phe Lys Arg Pro Thr Leu 
    130                 135                 140                 


Arg Arg Val Arg Ile Ser Ala Asp Ala Met Met Gln Ala Leu Leu Gly 
145                 150                 155                 160 


Ala Arg Ala Lys Glu Ser Leu Asp Leu Arg Ala His Leu Lys Gln Val 
                165                 170                 175     


Lys Lys Glu Asp Thr Glu Lys Glu Asn Arg Glu Val Gly Asp Trp Arg 
            180                 185                 190         


Lys Asn Ile Asp Ala Leu Ser Gly Met Glu Gly Arg Lys Lys Lys Phe 
        195                 200                 205             


Glu Ser 
    210 


<210>  34
<211>  212
<212>  PRT
<213>  mus musculus

<400>  34

Met Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Phe Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile 
    210         


<210>  35
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  35
cgaaattaat acgactcact atagggagac cacaacggtt tccc                        44


<210>  36
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  36
ggtaaaggta tagccgctcg                                                   20


<210>  37
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  37
ccagaaattt aaggataaag cgaccc                                            26


<210>  38
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  38
ggtcgcgcaa taatacaccg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  39
cggtgtatta ttgcgcgacc                                                   20


<210>  40
<211>  47
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  40
aacccccgca taggctgggg gttggaaagc ctctgaggac cagcacg                     47


<210>  41
<211>  63
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  41
gggagaccac aacggtttcc ctctagaaat aattttgttt aactttaaga aggagatata       60

cat                                                                     63


<210>  42
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  42
gctctgtttc acccatttca tataatamnn ggtaaaggta tagc                        44


<210>  43
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  43
gctctgtttc acccatttca tatamnnatc ggtaaaggta tagc                        44


<210>  44
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<400>  44
gctctgtttc acccatttca mnnaataatc ggtaaaggta tagc                        44


<210>  45
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<400>  45
gctctgtttc acccatttmn nataataatc ggtaaaggta tagc                        44


<210>  46
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<400>  46
gctctgtttc acccamnnca tataataatc ggtaaaggta tagc                        44


<210>  47
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  47
ccatggctct gtttcaccc                                                    19


<210>  48
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  48
cgagcggcta tacctttacc                                                   20


<210>  49
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is a, c, g, or t

<400>  49
gctatacctt taccnnktat tatatgaaat gggtgaaaca gagc                        44


<210>  50
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  50
gctatacctt taccgatnnk tatatgaaat gggtgaaaca gagc                        44


<210>  51
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  n is a, c, g, or t

<400>  51
gctatacctt taccgattat nnkatgaaat gggtgaaaca gagc                        44


<210>  52
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is a, c, g, or t

<400>  52
gctatacctt taccgattat tatnnkaaat gggtgaaaca gagc                        44


<210>  53
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<400>  53
gctatacctt taccgattat tatatgnnkt gggtgaaaca gagc                        44


<210>  54
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  n is a, c, g, or t

<400>  54
ccttaaattt ctggttataa aaggtttcgc cgttgttcgg attaatmnng ccaatccatt       60

ccagg                                                                   65


<210>  55
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n is a, c, g, or t

<400>  55
ccttaaattt ctggttataa aaggtttcgc cgttgttcgg attmnnatcg ccaatccatt       60

ccagg                                                                   65


<210>  56
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n is a, c, g, or t

<400>  56
ccttaaattt ctggttataa aaggtttcgc cgttgttcgg mnnaatatcg ccaatccatt       60

ccagg                                                                   65


<210>  57
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n is a, c, g, or t

<400>  57
ccttaaattt ctggttataa aaggtttcgc cgttgttmnn attaatatcg ccaatccatt       60

ccagg                                                                   65


<210>  58
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n is a, c, g, or t

<400>  58
ccttaaattt ctggttataa aaggtttcgc cgttmnncgg attaatatcg ccaatccatt       60

ccagg                                                                   65


<210>  59
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  n is a, c, g, or t

<400>  59
ccttaaattt ctggttataa aaggtttcgc cmnngttcgg attaatatcg ccaatccatt       60

ccagg                                                                   65


<210>  60
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  n is a, c, g, or t

<400>  60
ccttaaattt ctggttataa aaggtttcmn ngttgttcgg attaatatcg ccaatccatt       60

ccagg                                                                   65


<210>  61
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<400>  61
ccttaaattt ctggttataa aaggtmnngc cgttgttcgg attaatatcg ccaatccatt       60

ccagg                                                                   65


<210>  62
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is a, c, g, or t

<400>  62
ccttaaattt ctggttataa aamnnttcgc cgttgttcgg attaatatcg ccaatccatt       60

ccagg                                                                   65


<210>  63
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  n is a, c, g, or t

<400>  63
ccttaaattt ctggttatam nnggtttcgc cgttgttcgg attaatatcg ccaatccatt       60

ccagg                                                                   65


<210>  64
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  64
gggtcgcttt atccttaaat ttctgg                                            26


<210>  65
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  65
gcaaaagcct ggaatggatt ggc                                               23


<210>  66
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<400>  66
cctggaatgg attggcnnka ttaatccgaa caacggcgaa accttttata accagaaatt       60

taagg                                                                   65


<210>  67
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<400>  67
cctggaatgg attggcgatn nkaatccgaa caacggcgaa accttttata accagaaatt       60

taagg                                                                   65


<210>  68
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<400>  68
cctggaatgg attggcgata ttnnkccgaa caacggcgaa accttttata accagaaatt       60

taagg                                                                   65


<210>  69
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  69
cctggaatgg attggcgata ttaatnnkaa caacggcgaa accttttata accagaaatt       60

taagg                                                                   65


<210>  70
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  70
cctggaatgg attggcgata ttaatccgnn kaacggcgaa accttttata accagaaatt       60

taagg                                                                   65


<210>  71
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<400>  71
cctggaatgg attggcgata ttaatccgaa cnnkggcgaa accttttata accagaaatt       60

taagg                                                                   65


<210>  72
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<400>  72
cctggaatgg attggcgata ttaatccgaa caacnnkgaa accttttata accagaaatt       60

taagg                                                                   65


<210>  73
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<400>  73
cctggaatgg attggcgata ttaatccgaa caacggcnnk accttttata accagaaatt       60

taagg                                                                   65


<210>  74
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  n is a, c, g, or t

<400>  74
cctggaatgg attggcgata ttaatccgaa caacggcgaa nnkttttata accagaaatt       60

taagg                                                                   65


<210>  75
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  n is a, c, g, or t

<400>  75
cctggaatgg attggcgata ttaatccgaa caacggcgaa accnnktata accagaaatt       60

taagg                                                                   65


<210>  76
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  76
ggtaccctgg ccccaataat caaacacmnn ggtcgcgcaa taatacacc                   49


<210>  77
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  77
ggtaccctgg ccccaataat caaamnngcg ggtcgcgcaa taatacacc                   49


<210>  78
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<400>  78
ggtaccctgg ccccaataat cmnncacgcg ggtcgcgcaa taatacacc                   49


<210>  79
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<400>  79
ggtaccctgg ccccaatamn naaacacgcg ggtcgcgcaa taatacacc                   49


<210>  80
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<400>  80
ggtaccctgg ccccamnnat caaacacgcg ggtcgcgcaa taatacacc                   49


<210>  81
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  81
cggtcagggt ggtaccctgg c                                                 21


<210>  82
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  82
cggtgtatta ttgcgcgacc                                                   20


<210>  83
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<400>  83
ggtgtattat tgcgcgaccn nkgtgtttga ttattggggc cagggtacc                   49


<210>  84
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<400>  84
ggtgtattat tgcgcgaccc gcnnktttga ttattggggc cagggtacc                   49


<210>  85
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  85
ggtgtattat tgcgcgaccc gcgtgnnkga ttattggggc cagggtacc                   49


<210>  86
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  86
ggtgtattat tgcgcgaccc gcgtgtttnn ktattggggc cagggtacc                   49


<210>  87
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<400>  87
ggtgtattat tgcgcgaccc gcgtgtttga tnnktggggc cagggtacc                   49


<210>  88
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  88
ggaaagcctc tgaggaccag cacggatgcc ctgtgc                                 36


<210>  89
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  89
cgaaattaat acgactcact atagggagac cacaacggtt tccc                        44


<210>  90
<211>  47
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  90
aacccccgca taggctgggg gttggaaagc ctctgaggac cagcacg                     47


<210>  91
<211>  191
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  91
gggagaccac aacggtttcc ctctagaaat aattttgttt aactttaaga aggagatata       60

catatggaag tgcagctgca gcagagcggc ccggaactgg tgaaaccggg cgcgagcgtg      120

aaaatgagct gcaaagcgag cggctatacc tttaccgatt attatatgaa atgggtgaaa      180

cagagccatg g                                                           191


<210>  92
<211>  138
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  92
cgagcggcta tacctttacc gattattata tgaaatgggt gaaacagagc catggcaaaa       60

gcctggaatg gattggcgat attaatccga acaacggcga aaccttttat aaccagaaat      120

ttaaggataa agcgaccc                                                    138


<210>  93
<211>  210
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  93
gcaaaagcct ggaatggatt ggcgatatta atccgaacaa cggcgaaacc ttttataacc       60

agaaatttaa ggataaagcg accctgaccg tggataaaag cagcagcacc gcgtatatgc      120

agctgaacag cctgaccagc gaagatagcg cggtgtatta ttgcgcgacc cgcgtgtttg      180

attattgggg ccagggtacc accctgaccg                                       210


<210>  94
<211>  512
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  94
cggtgtatta ttgcgcgacc cgcgtgtttg attattgggg ccagggtacc accctgaccg       60

tgagcagcgc gaaaaccacc ccgccgagcg tgtatccgct ggcgccgggc agcgcggcgc      120

agaccaacag catggtgacc ctgggctgcc tggtgaaagg ctattttccg gaaccggtga      180

ccgtgacctg gaacagcggc agcctgagca gcggcgtgca tacctttccg gcggtgctgc      240

agagcgatct gtataccctg agcagcagcg tgaccgtgcc gagcagcacc tggccgagcg      300

aaaccgtgac ctgcaacgtg gcgcatccgg cgagcagcac caaagtggat aaaaaaattg      360

gagctggtgc aggctctggt gctggcgcag gttctccagc agcggtgccg gcagcagttc      420

ctgctgcggt gggcgaaggc gagggagagt tcagtacgcc agtttggatc tcgcaggcac      480

agggcatccg tgctggtcct cagaggcttt cc                                    512


<210>  95
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide

<400>  95
gctacaaacg cgtacgctat ggaagtgcag ctgcagcaga gcg                         43


