                               SEQUENCE LISTING

<110> RUBIUS THERAPEUTICS, INC.
 
<120> THERAPEUTIC CELL SYSTEMS AND METHODS FOR TREATING CANCER AND 
      INFECTIOUS DISEASES

<130> 129267-00220

<140>
<141>

<150> 62/757,717
<151> 2018-11-08

<150> 62/732,050
<151> 2018-09-17

<150> 62/692,487
<151> 2018-06-29

<150> 62/680,490
<151> 2018-06-04

<150> 62/660,657
<151> 2018-04-20

<150> 62/640,530
<151> 2018-03-08

<160> 83    

<170> PatentIn version 3.5

<210> 1
<211> 304
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
    130                 135                 140                 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
145                 150                 155                 160 


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
                165                 170                 175     


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
            180                 185                 190         


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
        195                 200                 205             


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
    210                 215                 220                 


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
225                 230                 235                 240 


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
                245                 250                 255     


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
            260                 265                 270         


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
        275                 280                 285             


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
    290                 295                 300                 


<210> 2
<211> 207
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
    130                 135                 140                 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
145                 150                 155                 160 


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
                165                 170                 175     


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
            180                 185                 190         


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
        195                 200                 205         


<210> 3
<211> 162
<212> PRT
<213> Homo sapiens

<400> 3
Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210> 4
<211> 114
<212> PRT
<213> Homo sapiens

<400> 4
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 5
<211> 267
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210> 6
<211> 237
<212> PRT
<213> Homo sapiens

<400> 6
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val 
                165                 170                 175     


Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser 
            180                 185                 190         


Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser 
        195                 200                 205             


Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser 
    210                 215                 220                 


Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 235         


<210> 7
<211> 205
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
        195                 200                 205 


<210> 8
<211> 175
<212> PRT
<213> Homo sapiens

<400> 8
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210> 9
<211> 65
<212> PRT
<213> Homo sapiens

<400> 9
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg 
65  


<210> 10
<211> 78
<212> PRT
<213> Homo sapiens

<400> 10
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
65                  70                  75              


<210> 11
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gly Gly Gly Gly Ser 
1               5   


<210> 12
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 13
<211> 342
<212> DNA
<213> Homo sapiens

<400> 13
aactgggtga acgttattag tgaccttaaa aagatcgaag atttgataca gtcaatgcac       60

atagacgcga cgctttatac agaatctgat gtacatcctt catgcaaggt tactgctatg      120

aagtgttttc ttctcgaact ccaagtaata agtcttgaga gcggagatgc gagcattcat      180

gacaccgttg agaatcttat tatattggct aacaactctc tgtccagcaa tggtaatgtg      240

acagaaagcg ggtgtaagga gtgcgaggaa ctcgaggaga agaacatcaa agagttcttg      300

cagtctttcg tccatattgt ccagatgttc ataaatacta gc                         342


<210> 14
<211> 342
<212> DNA
<213> Homo sapiens

<400> 14
aactgggtaa acgtcataag cgacctcaaa aagatcgagg accttataca gtctatgcac       60

atagatgcga cactttacac ggaatcagac gtgcacccgt cctgcaaagt cacagccatg      120

aagtgctttc ttctcgaact gcaggtaatt tctctcgaat caggtgacgc atctatccac      180

gacacagttg aaaatcttat tatcctggct aataactccc ttagctcaaa cggcaatgtc      240

accgagagtg gatgtaaaga atgtgaggaa cttgaagaga aaaacataaa ggaattcttg      300

cagagtttcg ttcatattgt gcaaatgttc atcaatacta gt                         342


<210> 15
<211> 525
<212> DNA
<213> Homo sapiens

<400> 15
atcacatgcc caccgcccat gtctgttgaa cacgcagaca tttgggttaa aagttactca       60

ctttactcac gcgagagata tatatgcaac agcggcttca agcgcaaagc aggcactagt      120

agtcttacag agtgcgtgct caataaagct acaaatgtag ctcattggac tactcctagt      180

ctcaaatgca ttcgggaccc cgcgcttgtg caccagagac ctgcgccgcc gtccacagtg      240

acgacagctg gtgtaacccc ccaacctgaa tcccttagtc cgtctggtaa agaaccggcg      300

gcgtcttcac cttccagcaa taatactgcg gcgacaacag ccgcgatagt tcctggatcc      360

caactcatgc cgtcaaagtc tccttcaacg ggaacgacag agatctcttc acatgaaagt      420

tctcatggaa caccgagcca aactacggca aagaactggg aactgactgc ctcagcaagc      480

caccagccgc caggggtgta cccgcaaggg cactcagata ctact                      525


<210> 16
<211> 234
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 16
atcacctgcc cgcctcccat gagcgtggaa cacgcggaca tttgggttaa gagctacagt       60

ctttacagcc gggagcgcta tatctgcaac tcagggttta agcggaaagc agggacatca      120

agtttgacag aatgtgtgtt gaacaaggct acaaatgttg ctcactggac cacgccatct      180

ttgaagtgta tccgagatcc cgcgcttgtc catcagcgcc cagcgcctcc ctcc            234


<210> 17
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 17
gggggaggtg gctctggtgg aggcgggagt ggcgggggcg gctca                       45


<210> 18
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 18
ggcggggggg gaagcggtgg tggagggagc gggggtggtg gatcc                       45


<210> 19
<211> 912
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 19
aactgggtga acgttattag tgaccttaaa aagatcgaag atttgataca gtcaatgcac       60

atagacgcga cgctttatac agaatctgat gtacatcctt catgcaaggt tactgctatg      120

aagtgttttc ttctcgaact ccaagtaata agtcttgaga gcggagatgc gagcattcat      180

gacaccgttg agaatcttat tatattggct aacaactctc tgtccagcaa tggtaatgtg      240

acagaaagcg ggtgtaagga gtgcgaggaa ctcgaggaga agaacatcaa agagttcttg      300

cagtctttcg tccatattgt ccagatgttc ataaatacta gcgggggagg tggctctggt      360

ggaggcggga gtggcggggg cggctcaatc acatgcccac cgcccatgtc tgttgaacac      420

gcagacattt gggttaaaag ttactcactt tactcacgcg agagatatat atgcaacagc      480

ggcttcaagc gcaaagcagg cactagtagt cttacagagt gcgtgctcaa taaagctaca      540

aatgtagctc attggactac tcctagtctc aaatgcattc gggaccccgc gcttgtgcac      600

cagagacctg cgccgccgtc cacagtgacg acagctggtg taacccccca acctgaatcc      660

cttagtccgt ctggtaaaga accggcggcg tcttcacctt ccagcaataa tactgcggcg      720

acaacagccg cgatagttcc tggatcccaa ctcatgccgt caaagtctcc ttcaacggga      780

acgacagaga tctcttcaca tgaaagttct catggaacac cgagccaaac tacggcaaag      840

aactgggaac tgactgcctc agcaagccac cagccgccag gggtgtaccc gcaagggcac      900

tcagatacta ct                                                          912


<210> 20
<211> 621
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 20
aactgggtaa acgtcataag cgacctcaaa aagatcgagg accttataca gtctatgcac       60

atagatgcga cactttacac ggaatcagac gtgcacccgt cctgcaaagt cacagccatg      120

aagtgctttc ttctcgaact gcaggtaatt tctctcgaat caggtgacgc atctatccac      180

gacacagttg aaaatcttat tatcctggct aataactccc ttagctcaaa cggcaatgtc      240

accgagagtg gatgtaaaga atgtgaggaa cttgaagaga aaaacataaa ggaattcttg      300

cagagtttcg ttcatattgt gcaaatgttc atcaatacta gtggcggggg gggaagcggt      360

ggtggaggga gcgggggtgg tggatccatc acctgcccgc ctcccatgag cgtggaacac      420

gcggacattt gggttaagag ctacagtctt tacagccggg agcgctatat ctgcaactca      480

gggtttaagc ggaaagcagg gacatcaagt ttgacagaat gtgtgttgaa caaggctaca      540

aatgttgctc actggaccac gccatctttg aagtgtatcc gagatcccgc gcttgtccat      600

cagcgcccag cgcctccctc c                                                621


<210> 21
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala 
            


<210> 22
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagca          57


<210> 23
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Gly Gly Ser Gly Gly Ser Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr 
1               5                   10                  15      


Ala Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25  


<210> 24
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
ggaggatctg gcgggtctgg aggctacccc tatgacgtgc ccgactatgc cggcggaggg       60

tctggaggcg gttcc                                                        75


<210> 25
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val 
1               5                   10                  15      


Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp 
            20                  25                  30          


Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val 
        35                  40                  45              


Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu 
    50                  55                  60                  


Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val 
65                  70                  75                  80  


Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg 
                85                  90                  95      


Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro 
            100                 105                 110         


Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr 
        115                 120                 125             


Ser Asp Gln 
    130     


<210> 26
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 26
ttaagtacca ctgaggtggc aatgcacact tcaacctctt cttcagtcac aaagagttac       60

atctcatcac agacaaatga tacgcacaaa cgggacacat atgcagccac tcctagagct      120

catgaagttt cagaaatttc tgttagaact gtttaccctc cagaagagga aaccggagaa      180

agggtacaac ttgcccatca tttctctgaa ccagagataa cactcattat ttttggggtg      240

atggctggtg ttattggaac gatcctctta atttcttacg gtattcgccg actgataaag      300

aaaagcccat ctgatgtaaa acctctcccc tcacctgaca cagacgtgcc tttaagttct      360

gttgaaatag aaaatccaga gacaagtgat caa                                   393


<210> 27
<211> 289
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Ser Gly Gly Ser Gly Gly Tyr Pro Tyr 
    130                 135                 140                 


Asp Val Pro Asp Tyr Ala Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser 
145                 150                 155                 160 


Thr Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys 
                165                 170                 175     


Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr 
            180                 185                 190         


Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr 
        195                 200                 205             


Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His 
    210                 215                 220                 


His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala 
225                 230                 235                 240 


Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu 
                245                 250                 255     


Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr 
            260                 265                 270         


Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp 
        275                 280                 285             


Gln 
    


<210> 28
<211> 867
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 28
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtaaatg tgatttcaga cctgaaaaaa atcgaagacc ttattcaatc catgcacatc      120

gacgcgacac tttatactga atcagacgta cacccgtcct gtaaggttac tgcgatgaag      180

tgctttctgt tggaattgca agtgatctcc ctcgaatcag gggatgcatc cattcatgat      240

accgtcgaga atttgatcat tctggcaaat aactccctca gtagtaacgg gaatgtgacc      300

gagtctgggt gtaaggagtg cgaagagttg gaggaaaaga atatcaaaga attccttcag      360

tcctttgttc acatcgtgca aatgtttatt aatacatctg gaggatctgg cgggtctgga      420

ggctacccct atgacgtgcc cgactatgcc ggcggagggt ctggaggcgg ttccttaagt      480

accactgagg tggcaatgca cacttcaacc tcttcttcag tcacaaagag ttacatctca      540

tcacagacaa atgatacgca caaacgggac acatatgcag ccactcctag agctcatgaa      600

gtttcagaaa tttctgttag aactgtttac cctccagaag aggaaaccgg agaaagggta      660

caacttgccc atcatttctc tgaaccagag ataacactca ttatttttgg ggtgatggct      720

ggtgttattg gaacgatcct cttaatttct tacggtattc gccgactgat aaagaaaagc      780

ccatctgatg taaaacctct cccctcacct gacacagacg tgcctttaag ttctgttgaa      840

atagaaaatc cagagacaag tgatcaa                                          867


<210> 29
<211> 479
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
145                 150                 155                 160 


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
                165                 170                 175     


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
            180                 185                 190         


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
        195                 200                 205             


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
    210                 215                 220                 


Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu 
225                 230                 235                 240 


Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn 
                245                 250                 255     


Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro 
            260                 265                 270         


Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser 
        275                 280                 285             


Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr 
    290                 295                 300                 


Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser 
305                 310                 315                 320 


Asp Thr Thr Gly Gly Ser Gly Gly Ser Gly Gly Tyr Pro Tyr Asp Val 
                325                 330                 335     


Pro Asp Tyr Ala Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr Thr 
            340                 345                 350         


Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr 
        355                 360                 365             


Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala 
    370                 375                 380                 


Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr 
385                 390                 395                 400 


Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe 
                405                 410                 415     


Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val 
            420                 425                 430         


Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys 
        435                 440                 445             


Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val 
    450                 455                 460                 


Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
465                 470                 475                 


<210> 30
<211> 1437
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 30
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtgaacg ttattagtga ccttaaaaag atcgaagatt tgatacagtc aatgcacata      120

gacgcgacgc tttatacaga atctgatgta catccttcat gcaaggttac tgctatgaag      180

tgttttcttc tcgaactcca agtaataagt cttgagagcg gagatgcgag cattcatgac      240

accgttgaga atcttattat attggctaac aactctctgt ccagcaatgg taatgtgaca      300

gaaagcgggt gtaaggagtg cgaggaactc gaggagaaga acatcaaaga gttcttgcag      360

tctttcgtcc atattgtcca gatgttcata aatactagcg ggggaggtgg ctctggtgga      420

ggcgggagtg gcgggggcgg ctcaatcaca tgcccaccgc ccatgtctgt tgaacacgca      480

gacatttggg ttaaaagtta ctcactttac tcacgcgaga gatatatatg caacagcggc      540

ttcaagcgca aagcaggcac tagtagtctt acagagtgcg tgctcaataa agctacaaat      600

gtagctcatt ggactactcc tagtctcaaa tgcattcggg accccgcgct tgtgcaccag      660

agacctgcgc cgccgtccac agtgacgaca gctggtgtaa ccccccaacc tgaatccctt      720

agtccgtctg gtaaagaacc ggcggcgtct tcaccttcca gcaataatac tgcggcgaca      780

acagccgcga tagttcctgg atcccaactc atgccgtcaa agtctccttc aacgggaacg      840

acagagatct cttcacatga aagttctcat ggaacaccga gccaaactac ggcaaagaac      900

tgggaactga ctgcctcagc aagccaccag ccgccagggg tgtacccgca agggcactca      960

gatactactg gaggatctgg cgggtctgga ggctacccct atgacgtgcc cgactatgcc     1020

ggcggagggt ctggaggcgg ttccttaagt accactgagg tggcaatgca cacttcaacc     1080

tcttcttcag tcacaaagag ttacatctca tcacagacaa atgatacgca caaacgggac     1140

acatatgcag ccactcctag agctcatgaa gtttcagaaa tttctgttag aactgtttac     1200

cctccagaag aggaaaccgg agaaagggta caacttgccc atcatttctc tgaaccagag     1260

ataacactca ttatttttgg ggtgatggct ggtgttattg gaacgatcct cttaatttct     1320

tacggtattc gccgactgat aaagaaaagc ccatctgatg taaaacctct cccctcacct     1380

gacacagacg tgcctttaag ttctgttgaa atagaaaatc cagagacaag tgatcaa        1437


<210> 31
<211> 382
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
145                 150                 155                 160 


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
                165                 170                 175     


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
            180                 185                 190         


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
        195                 200                 205             


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
    210                 215                 220                 


Pro Ser Gly Gly Ser Gly Gly Ser Gly Gly Tyr Pro Tyr Asp Val Pro 
225                 230                 235                 240 


Asp Tyr Ala Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr Thr Glu 
                245                 250                 255     


Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr Ile 
            260                 265                 270         


Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala Thr 
        275                 280                 285             


Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro 
    290                 295                 300                 


Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe Ser 
305                 310                 315                 320 


Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile 
                325                 330                 335     


Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys 
            340                 345                 350         


Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro 
        355                 360                 365             


Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
    370                 375                 380         


<210> 32
<211> 1146
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 32
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtaaacg tcataagcga cctcaaaaag atcgaggacc ttatacagtc tatgcacata      120

gatgcgacac tttacacgga atcagacgtg cacccgtcct gcaaagtcac agccatgaag      180

tgctttcttc tcgaactgca ggtaatttct ctcgaatcag gtgacgcatc tatccacgac      240

acagttgaaa atcttattat cctggctaat aactccctta gctcaaacgg caatgtcacc      300

gagagtggat gtaaagaatg tgaggaactt gaagagaaaa acataaagga attcttgcag      360

agtttcgttc atattgtgca aatgttcatc aatactagtg gcgggggggg aagcggtggt      420

ggagggagcg ggggtggtgg atccatcacc tgcccgcctc ccatgagcgt ggaacacgcg      480

gacatttggg ttaagagcta cagtctttac agccgggagc gctatatctg caactcaggg      540

tttaagcgga aagcagggac atcaagtttg acagaatgtg tgttgaacaa ggctacaaat      600

gttgctcact ggaccacgcc atctttgaag tgtatccgag atcccgcgct tgtccatcag      660

cgcccagcgc ctccctccgg aggatctggc gggtctggag gctaccccta tgacgtgccc      720

gactatgccg gcggagggtc tggaggcggt tccttaagta ccactgaggt ggcaatgcac      780

acttcaacct cttcttcagt cacaaagagt tacatctcat cacagacaaa tgatacgcac      840

aaacgggaca catatgcagc cactcctaga gctcatgaag tttcagaaat ttctgttaga      900

actgtttacc ctccagaaga ggaaaccgga gaaagggtac aacttgccca tcatttctct      960

gaaccagaga taacactcat tatttttggg gtgatggctg gtgttattgg aacgatcctc     1020

ttaatttctt acggtattcg ccgactgata aagaaaagcc catctgatgt aaaacctctc     1080

ccctcacctg acacagacgt gcctttaagt tctgttgaaa tagaaaatcc agagacaagt     1140

gatcaa                                                                1146


<210> 33
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210> 34
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
ggaggatctg gcgggtctgg aggcggcggc ggcagcggcg gcggcagcgg cggagggtct       60

ggaggcggtt cc                                                           72


<210> 35
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr 
145                 150                 155                 160 


Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser 
                165                 170                 175     


Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala 
            180                 185                 190         


Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val 
        195                 200                 205             


Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His 
    210                 215                 220                 


Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly 
225                 230                 235                 240 


Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile 
                245                 250                 255     


Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp 
            260                 265                 270         


Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
        275                 280                 285             


<210> 36
<211> 864
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 36
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtaaatg tgatttcaga cctgaaaaaa atcgaagacc ttattcaatc catgcacatc      120

gacgcgacac tttatactga atcagacgta cacccgtcct gtaaggttac tgcgatgaag      180

tgctttctgt tggaattgca agtgatctcc ctcgaatcag gggatgcatc cattcatgat      240

accgtcgaga atttgatcat tctggcaaat aactccctca gtagtaacgg gaatgtgacc      300

gagtctgggt gtaaggagtg cgaagagttg gaggaaaaga atatcaaaga attccttcag      360

tcctttgttc acatcgtgca aatgtttatt aatacatctg gaggatctgg cgggtctgga      420

ggcggcggcg gcagcggcgg cggcagcggc ggagggtctg gaggcggttc cttaagtacc      480

actgaggtgg caatgcacac ttcaacctct tcttcagtca caaagagtta catctcatca      540

cagacaaatg atacgcacaa acgggacaca tatgcagcca ctcctagagc tcatgaagtt      600

tcagaaattt ctgttagaac tgtttaccct ccagaagagg aaaccggaga aagggtacaa      660

cttgcccatc atttctctga accagagata acactcatta tttttggggt gatggctggt      720

gttattggaa cgatcctctt aatttcttac ggtattcgcc gactgataaa gaaaagccca      780

tctgatgtaa aacctctccc ctcacctgac acagacgtgc ctttaagttc tgttgaaata      840

gaaaatccag agacaagtga tcaa                                             864


<210> 37
<211> 478
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
145                 150                 155                 160 


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
                165                 170                 175     


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
            180                 185                 190         


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
        195                 200                 205             


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
    210                 215                 220                 


Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu 
225                 230                 235                 240 


Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn 
                245                 250                 255     


Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro 
            260                 265                 270         


Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser 
        275                 280                 285             


Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr 
    290                 295                 300                 


Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser 
305                 310                 315                 320 


Asp Thr Thr Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly 
                325                 330                 335     


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr Thr Glu 
            340                 345                 350         


Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr Ile 
        355                 360                 365             


Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala Thr 
    370                 375                 380                 


Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro 
385                 390                 395                 400 


Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe Ser 
                405                 410                 415     


Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile 
            420                 425                 430         


Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys 
        435                 440                 445             


Ser Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro 
    450                 455                 460                 


Leu Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
465                 470                 475             


<210> 38
<211> 1434
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 38
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaaac       60

tgggtgaacg ttattagtga ccttaaaaag atcgaagatt tgatacagtc aatgcacata      120

gacgcgacgc tttatacaga atctgatgta catccttcat gcaaggttac tgctatgaag      180

tgttttcttc tcgaactcca agtaataagt cttgagagcg gagatgcgag cattcatgac      240

accgttgaga atcttattat attggctaac aactctctgt ccagcaatgg taatgtgaca      300

gaaagcgggt gtaaggagtg cgaggaactc gaggagaaga acatcaaaga gttcttgcag      360

tctttcgtcc atattgtcca gatgttcata aatactagcg ggggaggtgg ctctggtgga      420

ggcgggagtg gcgggggcgg ctcaatcaca tgcccaccgc ccatgtctgt tgaacacgca      480

gacatttggg ttaaaagtta ctcactttac tcacgcgaga gatatatatg caacagcggc      540

ttcaagcgca aagcaggcac tagtagtctt acagagtgcg tgctcaataa agctacaaat      600

gtagctcatt ggactactcc tagtctcaaa tgcattcggg accccgcgct tgtgcaccag      660

agacctgcgc cgccgtccac agtgacgaca gctggtgtaa ccccccaacc tgaatccctt      720

agtccgtctg gtaaagaacc ggcggcgtct tcaccttcca gcaataatac tgcggcgaca      780

acagccgcga tagttcctgg atcccaactc atgccgtcaa agtctccttc aacgggaacg      840

acagagatct cttcacatga aagttctcat ggaacaccga gccaaactac ggcaaagaac      900

tgggaactga ctgcctcagc aagccaccag ccgccagggg tgtacccgca agggcactca      960

gatactactg gaggatctgg cgggtctgga ggcggcggcg gcagcggcgg cggcagcggc     1020

ggagggtctg gaggcggttc cttaagtacc actgaggtgg caatgcacac ttcaacctct     1080

tcttcagtca caaagagtta catctcatca cagacaaatg atacgcacaa acgggacaca     1140

tatgcagcca ctcctagagc tcatgaagtt tcagaaattt ctgttagaac tgtttaccct     1200

ccagaagagg aaaccggaga aagggtacaa cttgcccatc atttctctga accagagata     1260

acactcatta tttttggggt gatggctggt gttattggaa cgatcctctt aatttcttac     1320

ggtattcgcc gactgataaa gaaaagccca tctgatgtaa aacctctccc ctcacctgac     1380

acagacgtgc ctttaagttc tgttgaaata gaaaatccag agacaagtga tcaa           1434


<210> 39
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Gly Gly Ser Gly Gly Ser Gly Gly Gly Pro Glu Asp Glu Pro Gly Ser 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25      


<210> 40
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 40
ggaggatctg gcgggtctgg aggcggcccc gaggacgagc ccggcagcgg cagcggcgga       60

gggtctggag gcggttcc                                                     78


<210> 41
<211> 205
<212> PRT
<213> Homo sapiens

<400> 41
Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210> 42
<211> 615
<212> DNA
<213> Homo sapiens

<400> 42
gcctgcccct gggccgtgtc cggggctcgc gcctcgcccg gctccgcggc cagcccgaga       60

ctccgcgagg gtcccgagct ttcgcccgac gatcccgccg gcctcttgga cctgcggcag      120

ggcatgtttg cgcagctggt ggcccaaaat gttctgctga tcgatgggcc cctgagctgg      180

tacagtgacc caggcctggc aggcgtgtcc ctgacggggg gcctgagcta caaagaggac      240

acgaaggagc tggtggtggc caaggctgga gtctactatg tcttctttca actagagctg      300

cggcgcgtgg tggccggcga gggctcaggc tccgtttcac ttgcgctgca cctgcagcca      360

ctgcgctctg ctgctggggc cgccgccctg gctttgaccg tggacctgcc acccgcctcc      420

tccgaggctc ggaactcggc cttcggtttc cagggccgct tgctgcacct gagtgccggc      480

cagcgcctgg gcgtccatct tcacactgag gccagggcac gccatgcctg gcagcttacc      540

cagggcgcca cagtcttggg actcttccgg gtgacccccg aaatcccagc cggactccct      600

tcaccgaggt cggaa                                                       615


<210> 43
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 43
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro 
            20                  25                  30          


Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
        35                  40                  45              


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
    50                  55                  60                  


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
65                  70                  75                  80  


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
                85                  90                  95      


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
            100                 105                 110         


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
        115                 120                 125             


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
    130                 135                 140                 


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
145                 150                 155                 160 


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                165                 170                 175     


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
            180                 185                 190         


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
        195                 200                 205             


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    210                 215                 220                 


Gly Gly Ser Gly Gly Ser Gly Gly Gly Pro Glu Asp Glu Pro Gly Ser 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr Thr Glu Val 
                245                 250                 255     


Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr Ile Ser 
            260                 265                 270         


Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala Thr Pro 
        275                 280                 285             


Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Pro 
    290                 295                 300                 


Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe Ser Glu 
305                 310                 315                 320 


Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile Gly 
                325                 330                 335     


Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys Ser 
            340                 345                 350         


Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro Leu 
        355                 360                 365             


Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln 
    370                 375                 380     


<210> 44
<211> 1143
<212> DNA
<213> Homo sapiens

<400> 44
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcagcc       60

tgcccctggg ccgtgtccgg ggctcgcgcc tcgcccggct ccgcggccag cccgagactc      120

cgcgagggtc ccgagctttc gcccgacgat cccgccggcc tcttggacct gcggcagggc      180

atgtttgcgc agctggtggc ccaaaatgtt ctgctgatcg atgggcccct gagctggtac      240

agtgacccag gcctggcagg cgtgtccctg acggggggcc tgagctacaa agaggacacg      300

aaggagctgg tggtggccaa ggctggagtc tactatgtct tctttcaact agagctgcgg      360

cgcgtggtgg ccggcgaggg ctcaggctcc gtttcacttg cgctgcacct gcagccactg      420

cgctctgctg ctggggccgc cgccctggct ttgaccgtgg acctgccacc cgcctcctcc      480

gaggctcgga actcggcctt cggtttccag ggccgcttgc tgcacctgag tgccggccag      540

cgcctgggcg tccatcttca cactgaggcc agggcacgcc atgcctggca gcttacccag      600

ggcgccacag tcttgggact cttccgggtg acccccgaaa tcccagccgg actcccttca      660

ccgaggtcgg aaggaggatc tggcgggtct ggaggcggcc ccgaggacga gcccggcagc      720

ggcagcggcg gagggtctgg aggcggttcc ttaagtacca ctgaggtggc aatgcacact      780

tcaacctctt cttcagtcac aaagagttac atctcatcac agacaaatga tacgcacaaa      840

cgggacacat atgcagccac tcctagagct catgaagttt cagaaatttc tgttagaact      900

gtttaccctc cagaagagga aaccggagaa agggtacaac ttgcccatca tttctctgaa      960

ccagagataa cactcattat ttttggggtg atggctggtg ttattggaac gatcctctta     1020

atttcttacg gtattcgccg actgataaag aaaagcccat ctgatgtaaa acctctcccc     1080

tcacctgaca cagacgtgcc tttaagttct gttgaaatag aaaatccaga gacaagtgat     1140

caa                                                                   1143


<210> 45
<211> 306
<212> PRT
<213> Homo sapiens

<400> 45
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210> 46
<211> 918
<212> DNA
<213> Homo sapiens

<400> 46
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca       60

ggcgagatgg tggtgctgac ctgcgacaca cctgaggagg atggcatcac ctggacactg      120

gatcagagca gcgaggtgct gggctccggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac atgtcacaag ggaggagagg tgctgagcca ctccctgctg      240

ctgctgcaca agaaggagga cggcatctgg tctacagaca tcctgaagga tcagaaggag      300

cccaagaaca agaccttcct gcggtgcgag gccaagaatt atagcggccg gttcacctgt      360

tggtggctga ccacaatctc taccgacctg accttcagcg tgaagtctag ccggggctcc      420

tctgaccctc agggagtgac atgcggagca gccaccctgt ccgccgagcg ggtgagaggc      480

gataacaagg agtacgagta tagcgtggag tgccaggagg actccgcctg tccagcagca      540

gaggagagcc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacaagct ccttctttat cagggacatc atcaagcccg atccccctaa gaacctgcag      660

ctgaagcccc tgaagaacag ccggcaggtg gaggtgtctt gggagtaccc cgacacctgg      720

agcacacctc actcctattt ctctctgacc ttttgcgtgc aggtgcaggg caagtccaag      780

agggagaaga aggaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag      840

aacgcctcta tcagcgtgcg ggcccaggat agatactatt ctagctcctg gagcgagtgg      900

gcctccgtgc catgttct                                                    918


<210> 47
<211> 197
<212> PRT
<213> Homo sapiens

<400> 47
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 48
<211> 591
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 48
cggaatctgc cagtggcaac cccagacccc ggaatgttcc catgcctgca ccactctcag       60

aacctgctga gggccgtgag caatatgctg cagaaggccc gccagacact ggagttttac      120

ccttgtacca gcgaggagat cgaccacgag gacatcacaa aggataagac ctccacagtg      180

gaggcctgcc tgccactgga gctgaccaag aacgagagct gtctgaacag ccgggagacc      240

agcttcatca ccaacggcag ctgcctggcc tccagaaaga catcttttat gatggccctg      300

tgcctgtcta gcatctacga ggacctgaag atgtatcagg tggagttcaa gaccatgaac      360

gccaagctgc tgatggaccc caagaggcag attttcctgg accagaatat gctggccgtg      420

atcgacgagc tgatgcaggc cctgaacttt aattccgaga cagtgcctca gaagtcctct      480

ctggaggagc cagatttcta caagaccaag atcaagctgt gcatcctgct gcacgccttc      540

cggatcagag ccgtgaccat cgaccgcgtg atgagctatc tgaatgcctc c               591


<210> 49
<211> 78
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 49
Met Gln Pro Gln Glu Ser His Val His Tyr Ser Arg Trp Glu Asp Gly 
1               5                   10                  15      


Ser Arg Asp Gly Val Ser Leu Gly Ala Val Ser Ser Thr Glu Glu Ala 
            20                  25                  30          


Ser Arg Cys Arg Arg Ile Ser Gln Arg Leu Cys Thr Gly Lys Leu Gly 
        35                  40                  45              


Ile Ala Met Lys Val Leu Gly Gly Val Ala Leu Phe Trp Ile Ile Phe 
    50                  55                  60                  


Ile Leu Gly Tyr Leu Thr Gly Tyr Tyr Val His Lys Cys Lys 
65                  70                  75              


<210> 50
<211> 234
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 50
atgcaaccgc aagagagtca cgtacattat tcaagatggg aagatggaag tcgggacggt       60

gtgtctctcg gcgctgttag ttcaacggag gaagcgtctc gctgtcgccg gataagtcaa      120

cgcctttgta cgggaaaact gggtatagct atgaaggtcc tcggcggggt ggcgttgttt      180

tggattatct ttatacttgg gtatctgacc ggttactatg ttcacaagtg taaa            234


<210> 51
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210> 52
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 52
ggaggatctg gcgggtctgg aggcggcggc ggcagcggcg gcggcagcgg cggagggtct       60

ggaggcggtt cc                                                           72


<210> 53
<211> 692
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu 
            20                  25                  30          


Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp 
        35                  40                  45              


Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu 
    50                  55                  60                  


Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly 
65                  70                  75                  80  


Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His 
                85                  90                  95      


Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp 
            100                 105                 110         


Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys 
        115                 120                 125             


Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr 
    130                 135                 140                 


Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg 
                165                 170                 175     


Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu 
            180                 185                 190         


Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met 
        195                 200                 205             


Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe 
    210                 215                 220                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu 
225                 230                 235                 240 


Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val 
            260                 265                 270         


Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr 
        275                 280                 285             


Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser 
    290                 295                 300                 


Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala 
305                 310                 315                 320 


Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                325                 330                 335     


Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
            340                 345                 350         


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
        355                 360                 365             


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
    370                 375                 380                 


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
385                 390                 395                 400 


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
                405                 410                 415     


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
            420                 425                 430         


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
        435                 440                 445             


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
    450                 455                 460                 


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
465                 470                 475                 480 


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
                485                 490                 495     


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
            500                 505                 510         


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
        515                 520                 525             


Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
545                 550                 555                 560 


Ser Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser 
                565                 570                 575     


Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg 
            580                 585                 590         


Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser 
        595                 600                 605             


Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln 
    610                 615                 620                 


Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly 
625                 630                 635                 640 


Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile 
                645                 650                 655     


Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu Pro Ser 
            660                 665                 670         


Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn Pro Glu 
        675                 680                 685             


Thr Ser Asp Gln 
    690         


<210> 54
<211> 2076
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 54
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcaatc       60

tgggagctga agaaggacgt gtacgtggtg gagctggact ggtatcctga tgccccaggc      120

gagatggtgg tgctgacctg cgacacacct gaggaggatg gcatcacctg gacactggat      180

cagagcagcg aggtgctggg ctccggcaag accctgacaa tccaggtgaa ggagttcggc      240

gacgccggcc agtacacatg tcacaaggga ggagaggtgc tgagccactc cctgctgctg      300

ctgcacaaga aggaggacgg catctggtct acagacatcc tgaaggatca gaaggagccc      360

aagaacaaga ccttcctgcg gtgcgaggcc aagaattata gcggccggtt cacctgttgg      420

tggctgacca caatctctac cgacctgacc ttcagcgtga agtctagccg gggctcctct      480

gaccctcagg gagtgacatg cggagcagcc accctgtccg ccgagcgggt gagaggcgat      540

aacaaggagt acgagtatag cgtggagtgc caggaggact ccgcctgtcc agcagcagag      600

gagagcctgc caatcgaagt gatggtggat gccgtgcaca agctgaagta cgagaattat      660

acaagctcct tctttatcag ggacatcatc aagcccgatc cccctaagaa cctgcagctg      720

aagcccctga agaacagccg gcaggtggag gtgtcttggg agtaccccga cacctggagc      780

acacctcact cctatttctc tctgaccttt tgcgtgcagg tgcagggcaa gtccaagagg      840

gagaagaagg accgcgtgtt caccgataag acatctgcca ccgtgatctg tcggaagaac      900

gcctctatca gcgtgcgggc ccaggataga tactattcta gctcctggag cgagtgggcc      960

tccgtgccat gttctggagg aggaggcagc ggcggaggag gctccggcgg cggcggcagc     1020

cggaatctgc cagtggcaac cccagacccc ggaatgttcc catgcctgca ccactctcag     1080

aacctgctga gggccgtgag caatatgctg cagaaggccc gccagacact ggagttttac     1140

ccttgtacca gcgaggagat cgaccacgag gacatcacaa aggataagac ctccacagtg     1200

gaggcctgcc tgccactgga gctgaccaag aacgagagct gtctgaacag ccgggagacc     1260

agcttcatca ccaacggcag ctgcctggcc tccagaaaga catcttttat gatggccctg     1320

tgcctgtcta gcatctacga ggacctgaag atgtatcagg tggagttcaa gaccatgaac     1380

gccaagctgc tgatggaccc caagaggcag attttcctgg accagaatat gctggccgtg     1440

atcgacgagc tgatgcaggc cctgaacttt aattccgaga cagtgcctca gaagtcctct     1500

ctggaggagc cagatttcta caagaccaag atcaagctgt gcatcctgct gcacgccttc     1560

cggatcagag ccgtgaccat cgaccgcgtg atgagctatc tgaatgcctc cggaggatct     1620

ggcgggtctg gaggcggcgg cggcagcggc ggcggcagcg gcggagggtc tggaggcggt     1680

tccttaagta ccactgaggt ggcaatgcac acttcaacct cttcttcagt cacaaagagt     1740

tacatctcat cacagacaaa tgatacgcac aaacgggaca catatgcagc cactcctaga     1800

gctcatgaag tttcagaaat ttctgttaga actgtttacc ctccagaaga ggaaaccgga     1860

gaaagggtac aacttgccca tcatttctct gaaccagaga taacactcat tatttttggg     1920

gtgatggctg gtgttattgg aacgatcctc ttaatttctt acggtattcg ccgactgata     1980

aagaaaagcc catctgatgt aaaacctctc ccctcacctg acacagacgt gcctttaagt     2040

tctgttgaaa tagaaaatcc agagacaagt gatcaa                               2076


<210> 55
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Met Gln Pro Gln Glu Ser His Val His Tyr Ser Arg Trp Glu Asp Gly 
1               5                   10                  15      


Ser Arg Asp Gly Val Ser Leu Gly Ala Val Ser Ser Thr Glu Glu Ala 
            20                  25                  30          


Ser Arg Cys Arg Arg Ile Ser Gln Arg Leu Cys Thr Gly Lys Leu Gly 
        35                  40                  45              


Ile Ala Met Lys Val Leu Gly Gly Val Ala Leu Phe Trp Ile Ile Phe 
    50                  55                  60                  


Ile Leu Gly Tyr Leu Thr Gly Tyr Tyr Val His Lys Cys Lys Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Trp Glu 
                85                  90                  95      


Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala 
            100                 105                 110         


Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly 
        115                 120                 125             


Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys 
    130                 135                 140                 


Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr 
145                 150                 155                 160 


Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His 
                165                 170                 175     


Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys 
            180                 185                 190         


Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser 
        195                 200                 205             


Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr 
    210                 215                 220                 


Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr 
225                 230                 235                 240 


Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys 
                245                 250                 255     


Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala 
            260                 265                 270         


Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys 
        275                 280                 285             


Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile 
    290                 295                 300                 


Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser 
305                 310                 315                 320 


Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro 
                325                 330                 335     


His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser 
            340                 345                 350         


Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr 
        355                 360                 365             


Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg 
    370                 375                 380                 


Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Asn 
                405                 410                 415     


Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His 
            420                 425                 430         


Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg 
        435                 440                 445             


Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu 
    450                 455                 460                 


Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu 
465                 470                 475                 480 


Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe 
                485                 490                 495     


Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met 
            500                 505                 510         


Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val 
        515                 520                 525             


Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln 
    530                 535                 540                 


Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln 
545                 550                 555                 560 


Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu 
                565                 570                 575     


Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His 
            580                 585                 590         


Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu 
        595                 600                 605             


Asn Ala Ser 
    610     


<210> 56
<211> 1833
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 56
atgcaaccgc aagagagtca cgtacattat tcaagatggg aagatggaag tcgggacggt       60

gtgtctctcg gcgctgttag ttcaacggag gaagcgtctc gctgtcgccg gataagtcaa      120

cgcctttgta cgggaaaact gggtatagct atgaaggtcc tcggcggggt ggcgttgttt      180

tggattatct ttatacttgg gtatctgacc ggttactatg ttcacaagtg taaaggaggt      240

ggaggatcag gtggaggtgg ttcaggtgga ggaggtagca tctgggagct gaagaaggac      300

gtgtacgtgg tggagctgga ctggtatcct gatgccccag gcgagatggt ggtgctgacc      360

tgcgacacac ctgaggagga tggcatcacc tggacactgg atcagagcag cgaggtgctg      420

ggctccggca agaccctgac aatccaggtg aaggagttcg gcgacgccgg ccagtacaca      480

tgtcacaagg gaggagaggt gctgagccac tccctgctgc tgctgcacaa gaaggaggac      540

ggcatctggt ctacagacat cctgaaggat cagaaggagc ccaagaacaa gaccttcctg      600

cggtgcgagg ccaagaatta tagcggccgg ttcacctgtt ggtggctgac cacaatctct      660

accgacctga ccttcagcgt gaagtctagc cggggctcct ctgaccctca gggagtgaca      720

tgcggagcag ccaccctgtc cgccgagcgg gtgagaggcg ataacaagga gtacgagtat      780

agcgtggagt gccaggagga ctccgcctgt ccagcagcag aggagagcct gccaatcgaa      840

gtgatggtgg atgccgtgca caagctgaag tacgagaatt atacaagctc cttctttatc      900

agggacatca tcaagcccga tccccctaag aacctgcagc tgaagcccct gaagaacagc      960

cggcaggtgg aggtgtcttg ggagtacccc gacacctgga gcacacctca ctcctatttc     1020

tctctgacct tttgcgtgca ggtgcagggc aagtccaaga gggagaagaa ggaccgcgtg     1080

ttcaccgata agacatctgc caccgtgatc tgtcggaaga acgcctctat cagcgtgcgg     1140

gcccaggata gatactattc tagctcctgg agcgagtggg cctccgtgcc atgttctgga     1200

ggaggaggca gcggcggagg aggctccggc ggcggcggca gccggaatct gccagtggca     1260

accccagacc ccggaatgtt cccatgcctg caccactctc agaacctgct gagggccgtg     1320

agcaatatgc tgcagaaggc ccgccagaca ctggagtttt acccttgtac cagcgaggag     1380

atcgaccacg aggacatcac aaaggataag acctccacag tggaggcctg cctgccactg     1440

gagctgacca agaacgagag ctgtctgaac agccgggaga ccagcttcat caccaacggc     1500

agctgcctgg cctccagaaa gacatctttt atgatggccc tgtgcctgtc tagcatctac     1560

gaggacctga agatgtatca ggtggagttc aagaccatga acgccaagct gctgatggac     1620

cccaagaggc agattttcct ggaccagaat atgctggccg tgatcgacga gctgatgcag     1680

gccctgaact ttaattccga gacagtgcct cagaagtcct ctctggagga gccagatttc     1740

tacaagacca agatcaagct gtgcatcctg ctgcacgcct tccggatcag agccgtgacc     1800

atcgaccgcg tgatgagcta tctgaatgcc tcc                                  1833


<210> 57
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser 
        515             


<210> 58
<211> 1554
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 58
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca       60

ggcgagatgg tggtgctgac ctgcgacaca cctgaggagg atggcatcac ctggacactg      120

gatcagagca gcgaggtgct gggctccggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac atgtcacaag ggaggagagg tgctgagcca ctccctgctg      240

ctgctgcaca agaaggagga cggcatctgg tctacagaca tcctgaagga tcagaaggag      300

cccaagaaca agaccttcct gcggtgcgag gccaagaatt atagcggccg gttcacctgt      360

tggtggctga ccacaatctc taccgacctg accttcagcg tgaagtctag ccggggctcc      420

tctgaccctc agggagtgac atgcggagca gccaccctgt ccgccgagcg ggtgagaggc      480

gataacaagg agtacgagta tagcgtggag tgccaggagg actccgcctg tccagcagca      540

gaggagagcc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacaagct ccttctttat cagggacatc atcaagcccg atccccctaa gaacctgcag      660

ctgaagcccc tgaagaacag ccggcaggtg gaggtgtctt gggagtaccc cgacacctgg      720

agcacacctc actcctattt ctctctgacc ttttgcgtgc aggtgcaggg caagtccaag      780

agggagaaga aggaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag      840

aacgcctcta tcagcgtgcg ggcccaggat agatactatt ctagctcctg gagcgagtgg      900

gcctccgtgc catgttctgg aggaggaggc agcggcggag gaggctccgg cggcggcggc      960

agccggaatc tgccagtggc aaccccagac cccggaatgt tcccatgcct gcaccactct     1020

cagaacctgc tgagggccgt gagcaatatg ctgcagaagg cccgccagac actggagttt     1080

tacccttgta ccagcgagga gatcgaccac gaggacatca caaaggataa gacctccaca     1140

gtggaggcct gcctgccact ggagctgacc aagaacgaga gctgtctgaa cagccgggag     1200

accagcttca tcaccaacgg cagctgcctg gcctccagaa agacatcttt tatgatggcc     1260

ctgtgcctgt ctagcatcta cgaggacctg aagatgtatc aggtggagtt caagaccatg     1320

aacgccaagc tgctgatgga ccccaagagg cagattttcc tggaccagaa tatgctggcc     1380

gtgatcgacg agctgatgca ggccctgaac tttaattccg agacagtgcc tcagaagtcc     1440

tctctggagg agccagattt ctacaagacc aagatcaagc tgtgcatcct gctgcacgcc     1500

ttccggatca gagccgtgac catcgaccgc gtgatgagct atctgaatgc ctcc           1554


<210> 59
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 59
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly 
            20                  25                  30          


Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu 
        35                  40                  45              


Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile 
    50                  55                  60                  


Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu 
65                  70                  75                  80  


Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His 
                85                  90                  95      


Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr 
            100                 105                 110         


Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr 
        115                 120                 125             


Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His 
    130                 135                 140                 


Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val 
145                 150                 155                 160 


Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser 
                165                 170                 175     


Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu 
            180                 185                 190         


Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly 
        195                 200                 205             


Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr 
    210                 215                 220                 


Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu 
225                 230                 235             


<210> 60
<211> 475
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 60
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro 
            20                  25                  30          


Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu Leu Gly Gly 
        35                  40                  45              


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    50                  55                  60                  


Ser Leu Ser Pro Met Val Thr Cys Val Val Val Ala Val Ser Glu Asp 
65                  70                  75                  80  


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                85                  90                  95      


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            100                 105                 110         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        115                 120                 125             


Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ser Pro Ile Glu 
    130                 135                 140                 


Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala Pro Gln Val Tyr 
145                 150                 155                 160 


Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu Phe Ser Leu 
                165                 170                 175     


Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala Val Asp Trp 
            180                 185                 190         


Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr Ala Thr Val 
        195                 200                 205             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Gln 
    210                 215                 220                 


Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser Val Val His 
225                 230                 235                 240 


Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser Arg Ser Leu 
                245                 250                 255     


Gly Lys Glu Asn Leu Tyr Phe Gln Gly Gly Ile Thr Cys Pro Pro Pro 
            260                 265                 270         


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
        275                 280                 285             


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
    290                 295                 300                 


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
305                 310                 315                 320 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Gly Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Ser Gly Ser Glu Asp Glu Asp Glu Asp Glu Asp Gly 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Ser Gly Ser Asn Trp Val Asn Val Ile Ser 
        355                 360                 365             


Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
    370                 375                 380                 


Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
385                 390                 395                 400 


Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
                405                 410                 415     


Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn 
            420                 425                 430         


Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu 
        435                 440                 445             


Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
    450                 455                 460                 


Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
465                 470                 475 


<210> 61
<211> 794
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro 
            20                  25                  30          


Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu Leu Gly Gly 
        35                  40                  45              


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    50                  55                  60                  


Ser Leu Ser Pro Met Val Thr Cys Val Val Val Ala Val Ser Glu Asp 
65                  70                  75                  80  


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                85                  90                  95      


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            100                 105                 110         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        115                 120                 125             


Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ser Pro Ile Glu 
    130                 135                 140                 


Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala Pro Gln Val Tyr 
145                 150                 155                 160 


Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu Phe Ser Leu 
                165                 170                 175     


Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala Val Asp Trp 
            180                 185                 190         


Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr Ala Thr Val 
        195                 200                 205             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Gln 
    210                 215                 220                 


Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser Val Val His 
225                 230                 235                 240 


Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser Arg Ser Leu 
                245                 250                 255     


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp 
        275                 280                 285             


Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro 
    290                 295                 300                 


Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile 
305                 310                 315                 320 


Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala 
                325                 330                 335     


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His 
            340                 345                 350         


Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu 
        355                 360                 365             


Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr 
    370                 375                 380                 


Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu 
385                 390                 395                 400 


Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val 
                405                 410                 415     


Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln 
            420                 425                 430         


Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys 
        435                 440                 445             


Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg 
    450                 455                 460                 


Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp 
465                 470                 475                 480 


Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys 
                485                 490                 495     


Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr 
            500                 505                 510         


Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys 
        515                 520                 525             


Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala 
    530                 535                 540                 


Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn 
545                 550                 555                 560 


Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys 
                565                 570                 575     


Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly 
        595                 600                 605             


Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp 
    610                 615                 620                 


Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr 
625                 630                 635                 640 


Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr 
                645                 650                 655     


Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu 
            660                 665                 670         


Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro 
        675                 680                 685             


Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu 
    690                 695                 700                 


Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu 
705                 710                 715                 720 


Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val 
                725                 730                 735     


Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu 
            740                 745                 750         


Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met 
        755                 760                 765             


Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile 
    770                 775                 780                 


Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
785                 790                 


<210> 62
<211> 1015
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 62
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro 
            20                  25                  30          


Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
        35                  40                  45              


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
    50                  55                  60                  


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
65                  70                  75                  80  


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
                85                  90                  95      


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
            100                 105                 110         


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
        115                 120                 125             


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
    130                 135                 140                 


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
145                 150                 155                 160 


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                165                 170                 175     


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
            180                 185                 190         


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
        195                 200                 205             


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    210                 215                 220                 


Gly Gly Ser Gly Gly Ser Gly Gly Gly Pro Glu Asp Glu Pro Gly Ser 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Thr Thr Glu Val 
                245                 250                 255     


Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr Ile Ser 
            260                 265                 270         


Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala Thr Pro 
        275                 280                 285             


Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Pro 
    290                 295                 300                 


Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe Ser Glu 
305                 310                 315                 320 


Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile Gly 
                325                 330                 335     


Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys Ser 
            340                 345                 350         


Pro Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro Leu 
        355                 360                 365             


Ser Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln Ala Ala Ala 
    370                 375                 380                 


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
385                 390                 395                 400 


Gly Pro Ser Gly Met Gln Pro Gln Glu Ser His Val His Tyr Ser Arg 
                405                 410                 415     


Trp Glu Asp Gly Ser Arg Asp Gly Val Ser Leu Gly Ala Val Ser Ser 
            420                 425                 430         


Thr Glu Glu Ala Ser Arg Cys Arg Arg Ile Ser Gln Arg Leu Cys Thr 
        435                 440                 445             


Gly Lys Leu Gly Ile Ala Met Lys Val Leu Gly Gly Val Ala Leu Phe 
    450                 455                 460                 


Trp Ile Ile Phe Ile Leu Gly Tyr Leu Thr Gly Tyr Tyr Val His Lys 
465                 470                 475                 480 


Cys Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
            500                 505                 510         


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
        515                 520                 525             


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
    530                 535                 540                 


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
545                 550                 555                 560 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
                565                 570                 575     


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
            580                 585                 590         


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
        595                 600                 605             


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
    610                 615                 620                 


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
625                 630                 635                 640 


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
                645                 650                 655     


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
            660                 665                 670         


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
        675                 680                 685             


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
    690                 695                 700                 


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
705                 710                 715                 720 


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
                725                 730                 735     


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
            740                 745                 750         


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
        755                 760                 765             


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
    770                 775                 780                 


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
785                 790                 795                 800 


Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                805                 810                 815     


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
            820                 825                 830         


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
        835                 840                 845             


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
    850                 855                 860                 


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
865                 870                 875                 880 


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
                885                 890                 895     


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
            900                 905                 910         


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
        915                 920                 925             


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
    930                 935                 940                 


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
945                 950                 955                 960 


Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys 
                965                 970                 975     


Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
            980                 985                 990         


Ile Leu Leu His Ala Phe Arg Ile  Arg Ala Val Thr Ile  Asp Arg Val 
        995                 1000                 1005             


Met Ser  Tyr Leu Asn Ala Ser  
    1010                 1015 


<210> 63
<211> 3048
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 63
atgtatggaa aaataatctt tgtattacta ttgtcagaaa ttgtgagcat atcagcagcc       60

tgcccctggg ccgtgtccgg ggctcgcgcc tcgcccggct ccgcggccag cccgagactc      120

cgcgagggtc ccgagctttc gcccgacgat cccgccggcc tcttggacct gcggcagggc      180

atgtttgcgc agctggtggc ccaaaatgtt ctgctgatcg atgggcccct gagctggtac      240

agtgacccag gcctggcagg cgtgtccctg acggggggcc tgagctacaa agaggacacg      300

aaggagctgg tggtggccaa ggctggagtc tactatgtct tctttcaact agagctgcgg      360

cgcgtggtgg ccggcgaggg ctcaggctcc gtttcacttg cgctgcacct gcagccactg      420

cgctctgctg ctggggccgc cgccctggct ttgaccgtgg acctgccacc cgcctcctcc      480

gaggctcgga actcggcctt cggtttccag ggccgcttgc tgcacctgag tgccggccag      540

cgcctgggcg tccatcttca cactgaggcc agggcacgcc atgcctggca gcttacccag      600

ggcgccacag tcttgggact cttccgggtg acccccgaaa tcccagccgg actcccttca      660

ccgaggtcgg aaggaggatc tggcgggtct ggaggcggcc ccgaggacga gcccggcagc      720

ggcagcggcg gagggtctgg aggcggttcc ttaagtacca ctgaggtggc aatgcacact      780

tcaacctctt cttcagtcac aaagagttac atctcatcac agacaaatga tacgcacaaa      840

cgggacacat atgcagccac tcctagagct catgaagttt cagaaatttc tgttagaact      900

gtttaccctc cagaagagga aaccggagaa agggtacaac ttgcccatca tttctctgaa      960

ccagagataa cactcattat ttttggggtg atggctggtg ttattggaac gatcctctta     1020

atttcttacg gtattcgccg actgataaag aaaagcccat ctgatgtaaa acctctcccc     1080

tcacctgaca cagacgtgcc tttaagttct gttgaaatag aaaatccaga gacaagtgat     1140

caagcggccg ctgagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc     1200

ggcccttccg gaatgcaacc gcaagagagt cacgtacatt attcaagatg ggaagatgga     1260

agtcgggacg gtgtgtctct cggcgctgtt agttcaacgg aggaagcgtc tcgctgtcgc     1320

cggataagtc aacgcctttg tacgggaaaa ctgggtatag ctatgaaggt cctcggcggg     1380

gtggcgttgt tttggattat ctttatactt gggtatctga ccggttacta tgttcacaag     1440

tgtaaaggag gtggaggatc aggtggaggt ggttcaggtg gaggaggtag catctgggag     1500

ctgaagaagg acgtgtacgt ggtggagctg gactggtatc ctgatgcccc aggcgagatg     1560

gtggtgctga cctgcgacac acctgaggag gatggcatca cctggacact ggatcagagc     1620

agcgaggtgc tgggctccgg caagaccctg acaatccagg tgaaggagtt cggcgacgcc     1680

ggccagtaca catgtcacaa gggaggagag gtgctgagcc actccctgct gctgctgcac     1740

aagaaggagg acggcatctg gtctacagac atcctgaagg atcagaagga gcccaagaac     1800

aagaccttcc tgcggtgcga ggccaagaat tatagcggcc ggttcacctg ttggtggctg     1860

accacaatct ctaccgacct gaccttcagc gtgaagtcta gccggggctc ctctgaccct     1920

cagggagtga catgcggagc agccaccctg tccgccgagc gggtgagagg cgataacaag     1980

gagtacgagt atagcgtgga gtgccaggag gactccgcct gtccagcagc agaggagagc     2040

ctgccaatcg aagtgatggt ggatgccgtg cacaagctga agtacgagaa ttatacaagc     2100

tccttcttta tcagggacat catcaagccc gatcccccta agaacctgca gctgaagccc     2160

ctgaagaaca gccggcaggt ggaggtgtct tgggagtacc ccgacacctg gagcacacct     2220

cactcctatt tctctctgac cttttgcgtg caggtgcagg gcaagtccaa gagggagaag     2280

aaggaccgcg tgttcaccga taagacatct gccaccgtga tctgtcggaa gaacgcctct     2340

atcagcgtgc gggcccagga tagatactat tctagctcct ggagcgagtg ggcctccgtg     2400

ccatgttctg gaggaggagg cagcggcgga ggaggctccg gcggcggcgg cagccggaat     2460

ctgccagtgg caaccccaga ccccggaatg ttcccatgcc tgcaccactc tcagaacctg     2520

ctgagggccg tgagcaatat gctgcagaag gcccgccaga cactggagtt ttacccttgt     2580

accagcgagg agatcgacca cgaggacatc acaaaggata agacctccac agtggaggcc     2640

tgcctgccac tggagctgac caagaacgag agctgtctga acagccggga gaccagcttc     2700

atcaccaacg gcagctgcct ggcctccaga aagacatctt ttatgatggc cctgtgcctg     2760

tctagcatct acgaggacct gaagatgtat caggtggagt tcaagaccat gaacgccaag     2820

ctgctgatgg accccaagag gcagattttc ctggaccaga atatgctggc cgtgatcgac     2880

gagctgatgc aggccctgaa ctttaattcc gagacagtgc ctcagaagtc ctctctggag     2940

gagccagatt tctacaagac caagatcaag ctgtgcatcc tgctgcacgc cttccggatc     3000

agagccgtga ccatcgaccg cgtgatgagc tatctgaatg cctcctag                  3048


<210> 64
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Ala Ala Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro Ser Gly 
            20              


<210> 65
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 65
gcggccgctg agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc       60

ccttccgga                                                               69


<210> 66
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 66
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Ala Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
        35                  40                  45              


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
    50                  55                  60                  


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 
65                  70                  75                  80  


Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
                85                  90                  95      


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
            100                 105                 110         


Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 
        115                 120                 125             


Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 
    130                 135                 140                 


Pro Glu Thr Ser Asp Gln 
145                 150 


<210> 67
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Glu Asp Glu Asp Glu Asp 
1               5                   10                  15      


Glu Asp Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25              


<210> 68
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 69
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 69
Gly Ser Gly Ser Gly Ser Gly Ser Glu Asp Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser 
        


<210> 70
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 70
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser 
        


<210> 71
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 71
Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 72
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Ser Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Ser Pro Ala 
            20                  25      


<210> 73
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  


<210> 74
<211> 58
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 74
Ser Gly Arg Gly Ala Ser Ser Gly Ser Ser Gly Ser Gly Ser Gln Lys 
1               5                   10                  15      


Lys Pro Arg Tyr Glu Ile Arg Trp Lys Val Val Val Ile Ser Ala Ile 
            20                  25                  30          


Leu Ala Leu Val Val Leu Thr Val Ile Ser Leu Ile Ile Leu Ile Met 
        35                  40                  45              


Leu Trp Gly Ser Gly Met Gln Ser Pro Ala 
    50                  55              


<210> 75
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (1)..(50)
<223> /note="This sequence may encompass 1-10 
      "Gly-Gly-Gly-Gly-Ser" repeating units"

<400> 75
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210> 76
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 76
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210> 77
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 77
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys 
            20  


<210> 78
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 78
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 79
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 80
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 80
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 81
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 81
gagggcagag gaagtcttct aacatgcggt gacgtggagg sgsstcccgg ccct             54


<210> 82
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 82
Leu Pro Xaa Thr Gly 
1               5   


<210> 83
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 83
Leu Pro Xaa Thr Ala 
1               5   


