                               SEQUENCE LISTING

<110> APPLIED MOLECULAR TRANSPORT INC.
 
<120> NOVEL TOXIN-DERIVED DELIVERY CONSTRUCTS FOR ORAL DELIVERY 
 

<130> 40566-711.601

<140>
<141>

<150> 62/640,168
<151> 2018-03-08

<150> 62/640,194
<151> 2018-03-08

<150> 62/640,188
<151> 2018-03-08

<160> 221   

<170> PatentIn version 3.5

<210> 1
<211> 634
<212> PRT
<213> Vibrio cholera

<400> 1
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 2
<211> 634
<212> PRT
<213> Vibrio cholera

<400> 2
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 3
<211> 634
<212> PRT
<213> Vibrio cholera

<400> 3
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Ala Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 4
<211> 265
<212> PRT
<213> Vibrio cholera

<400> 4
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys 
            260                 265 


<210> 5
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys 
            260                 265     


<210> 6
<211> 250
<212> PRT
<213> Vibrio cholera

<400> 6
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln 
                245                 250 


<210> 7
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln 
                245                 250     


<210> 8
<211> 244
<212> PRT
<213> Vibrio cholera

<400> 8
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys 
                


<210> 9
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys 
                245 


<210> 10
<211> 205
<212> PRT
<213> Vibrio cholera

<400> 10
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu 
        195                 200                 205 


<210> 11
<211> 206
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu 
        195                 200                 205     


<210> 12
<211> 204
<212> PRT
<213> Vibrio cholera

<400> 12
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly 
        195                 200                 


<210> 13
<211> 203
<212> PRT
<213> Vibrio cholera

<400> 13
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr 
        195                 200             


<210> 14
<211> 202
<212> PRT
<213> Vibrio cholera

<400> 14
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His 
        195                 200         


<210> 15
<211> 201
<212> PRT
<213> Vibrio cholera

<400> 15
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp 
        195                 200     


<210> 16
<211> 200
<212> PRT
<213> Vibrio cholera

<400> 16
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His 
        195                 200 


<210> 17
<211> 199
<212> PRT
<213> Vibrio cholera

<400> 17
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala 
        195                 


<210> 18
<211> 198
<212> PRT
<213> Vibrio cholera

<400> 18
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp 
        195             


<210> 19
<211> 197
<212> PRT
<213> Vibrio cholera

<400> 19
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg 
        195         


<210> 20
<211> 196
<212> PRT
<213> Vibrio cholera

<400> 20
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys 
        195     


<210> 21
<211> 195
<212> PRT
<213> Vibrio cholera

<400> 21
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His 
        195 


<210> 22
<211> 194
<212> PRT
<213> Vibrio cholera

<400> 22
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg 
        


<210> 23
<211> 193
<212> PRT
<213> Vibrio cholera

<400> 23
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser 
    


<210> 24
<211> 192
<212> PRT
<213> Vibrio cholera

<400> 24
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


<210> 25
<211> 191
<212> PRT
<213> Vibrio cholera

<400> 25
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190     


<210> 26
<211> 190
<212> PRT
<213> Vibrio cholera

<400> 26
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
            180                 185                 190 


<210> 27
<211> 189
<212> PRT
<213> Vibrio cholera

<400> 27
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln 
            180                 185                 


<210> 28
<211> 188
<212> PRT
<213> Vibrio cholera

<400> 28
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala 
            180                 185             


<210> 29
<211> 187
<212> PRT
<213> Vibrio cholera

<400> 29
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala 
            180                 185         


<210> 30
<211> 186
<212> PRT
<213> Vibrio cholera

<400> 30
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
            180                 185     


<210> 31
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
            180                 185         


<210> 32
<211> 185
<212> PRT
<213> Vibrio cholera

<400> 32
Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser Leu 
1               5                   10                  15      


Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser 
            20                  25                  30          


Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn 
        35                  40                  45              


Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile 
    50                  55                  60                  


Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn 
65                  70                  75                  80  


Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn 
                85                  90                  95      


Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile 
            100                 105                 110         


Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile 
        115                 120                 125             


Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys 
    130                 135                 140                 


Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr 
145                 150                 155                 160 


Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala 
                165                 170                 175     


Ile Ser Trp Pro Ser Val Ser Tyr Lys 
            180                 185 


<210> 33
<211> 184
<212> PRT
<213> Vibrio cholera

<400> 33
Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser Leu Thr 
1               5                   10                  15      


Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp 
            20                  25                  30          


Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp 
        35                  40                  45              


Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr 
    50                  55                  60                  


Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln 
65                  70                  75                  80  


Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly 
                85                  90                  95      


Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn 
            100                 105                 110         


Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser 
        115                 120                 125             


Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu 
    130                 135                 140                 


Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln 
145                 150                 155                 160 


Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile 
                165                 170                 175     


Ser Trp Pro Ser Val Ser Tyr Lys 
            180                 


<210> 34
<211> 183
<212> PRT
<213> Vibrio cholera

<400> 34
Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser Leu Thr Pro 
1               5                   10                  15      


Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val 
            20                  25                  30          


Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu 
        35                  40                  45              


Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile 
    50                  55                  60                  


Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp 
65                  70                  75                  80  


Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr 
                85                  90                  95      


Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp 
            100                 105                 110         


Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val 
        115                 120                 125             


Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr 
    130                 135                 140                 


Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly 
145                 150                 155                 160 


Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser 
                165                 170                 175     


Trp Pro Ser Val Ser Tyr Lys 
            180             


<210> 35
<211> 182
<212> PRT
<213> Vibrio cholera

<400> 35
Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser Leu Thr Pro Glu 
1               5                   10                  15      


Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val 
            20                  25                  30          


Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln 
        35                  40                  45              


Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly 
    50                  55                  60                  


Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala 
65                  70                  75                  80  


Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys 
                85                  90                  95      


Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu 
            100                 105                 110         


Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp 
        115                 120                 125             


Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser 
    130                 135                 140                 


Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn 
145                 150                 155                 160 


Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp 
                165                 170                 175     


Pro Ser Val Ser Tyr Lys 
            180         


<210> 36
<211> 181
<212> PRT
<213> Vibrio cholera

<400> 36
Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser Leu Thr Pro Glu Pro 
1               5                   10                  15      


Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu 
            20                  25                  30          


Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn 
        35                  40                  45              


Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu 
    50                  55                  60                  


Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr 
                85                  90                  95      


Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val 
            100                 105                 110         


Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu 
        115                 120                 125             


Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile 
    130                 135                 140                 


Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val 
145                 150                 155                 160 


Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro 
                165                 170                 175     


Ser Val Ser Tyr Lys 
            180     


<210> 37
<211> 180
<212> PRT
<213> Vibrio cholera

<400> 37
Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser Leu Thr Pro Glu Pro Gly 
1               5                   10                  15      


Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp 
            20                  25                  30          


Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp 
        35                  40                  45              


Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe 
    50                  55                  60                  


Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe 
65                  70                  75                  80  


Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr 
                85                  90                  95      


Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro 
            100                 105                 110         


Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu 
        115                 120                 125             


Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp 
    130                 135                 140                 


Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser 
145                 150                 155                 160 


Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser 
                165                 170                 175     


Val Ser Tyr Lys 
            180 


<210> 38
<211> 179
<212> PRT
<213> Vibrio cholera

<400> 38
Phe Asp Glu Cys Arg Ser Pro Cys Ser Leu Thr Pro Glu Pro Gly Lys 
1               5                   10                  15      


Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu 
            20                  25                  30          


Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile 
        35                  40                  45              


Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala 
    50                  55                  60                  


Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly 
65                  70                  75                  80  


Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser 
                85                  90                  95      


Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile 
            100                 105                 110         


Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp 
        115                 120                 125             


Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu 
    130                 135                 140                 


Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe 
145                 150                 155                 160 


Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val 
                165                 170                 175     


Ser Tyr Lys 
            


<210> 39
<211> 178
<212> PRT
<213> Vibrio cholera

<400> 39
Asp Glu Cys Arg Ser Pro Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro 
1               5                   10                  15      


Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly 
            20                  25                  30          


Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys 
        35                  40                  45              


Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr 
    50                  55                  60                  


Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val 
65                  70                  75                  80  


Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr 
                85                  90                  95      


Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly 
            100                 105                 110         


Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln 
        115                 120                 125             


Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp 
    130                 135                 140                 


Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser 
145                 150                 155                 160 


Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser 
                165                 170                 175     


Tyr Lys 
        


<210> 40
<211> 177
<212> PRT
<213> Vibrio cholera

<400> 40
Glu Cys Arg Ser Pro Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile 
1               5                   10                  15      


Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val 
            20                  25                  30          


Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp 
        35                  40                  45              


Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val 
    50                  55                  60                  


Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile 
65                  70                  75                  80  


His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn 
                85                  90                  95      


Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu 
            100                 105                 110         


Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln 
        115                 120                 125             


Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn 
    130                 135                 140                 


Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val 
145                 150                 155                 160 


Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr 
                165                 170                 175     


Lys 
    


<210> 41
<211> 176
<212> PRT
<213> Vibrio cholera

<400> 41
Cys Arg Ser Pro Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln 
1               5                   10                  15      


Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu 
            20                  25                  30          


Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu 
        35                  40                  45              


Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg 
    50                  55                  60                  


Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His 
65                  70                  75                  80  


Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg 
                85                  90                  95      


Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp 
            100                 105                 110         


Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg 
        115                 120                 125             


Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln 
    130                 135                 140                 


Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr 
145                 150                 155                 160 


Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
                165                 170                 175     


<210> 42
<211> 175
<212> PRT
<213> Vibrio cholera

<400> 42
Arg Ser Pro Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser 
1               5                   10                  15      


Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr 
            20                  25                  30          


Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp 
        35                  40                  45              


Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala 
    50                  55                  60                  


Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu 
65                  70                  75                  80  


Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys 
                85                  90                  95      


Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser 
            100                 105                 110         


Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn 
        115                 120                 125             


Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr 
    130                 135                 140                 


Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg 
145                 150                 155                 160 


Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
                165                 170                 175 


<210> 43
<211> 174
<212> PRT
<213> Vibrio cholera

<400> 43
Ser Pro Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys 
1               5                   10                  15      


Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr 
            20                  25                  30          


Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys 
        35                  40                  45              


Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr 
    50                  55                  60                  


Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp 
65                  70                  75                  80  


Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu 
                85                  90                  95      


Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro 
            100                 105                 110         


Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile 
        115                 120                 125             


Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu 
    130                 135                 140                 


Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro 
145                 150                 155                 160 


Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
                165                 170                 


<210> 44
<211> 173
<212> PRT
<213> Vibrio cholera

<400> 44
Pro Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu 
1               5                   10                  15      


Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser 
            20                  25                  30          


Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly 
        35                  40                  45              


Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg 
    50                  55                  60                  


His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile 
65                  70                  75                  80  


Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly 
                85                  90                  95      


Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala 
            100                 105                 110         


Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile 
        115                 120                 125             


Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu 
    130                 135                 140                 


Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu 
145                 150                 155                 160 


His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
                165                 170             


<210> 45
<211> 172
<212> PRT
<213> Vibrio cholera

<400> 45
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
                165                 170         


<210> 46
<211> 171
<212> PRT
<213> Vibrio cholera

<400> 46
Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
1               5                   10                  15      


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
            20                  25                  30          


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
        35                  40                  45              


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
    50                  55                  60                  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
65                  70                  75                  80  


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
                85                  90                  95      


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
            100                 105                 110         


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
        115                 120                 125             


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
    130                 135                 140                 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
145                 150                 155                 160 


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
                165                 170     


<210> 47
<211> 170
<212> PRT
<213> Vibrio cholera

<400> 47
Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
1               5                   10                  15      


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
            20                  25                  30          


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
        35                  40                  45              


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
    50                  55                  60                  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
65                  70                  75                  80  


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
                85                  90                  95      


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
            100                 105                 110         


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
        115                 120                 125             


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
    130                 135                 140                 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
145                 150                 155                 160 


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
                165                 170 


<210> 48
<211> 169
<212> PRT
<213> Vibrio cholera

<400> 48
Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser 
1               5                   10                  15      


Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn 
            20                  25                  30          


Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile 
        35                  40                  45              


Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn 
    50                  55                  60                  


Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn 
65                  70                  75                  80  


Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile 
                85                  90                  95      


Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile 
            100                 105                 110         


Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys 
        115                 120                 125             


Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr 
    130                 135                 140                 


Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala 
145                 150                 155                 160 


Ile Ser Trp Pro Ser Val Ser Tyr Lys 
                165                 


<210> 49
<211> 168
<212> PRT
<213> Vibrio cholera

<400> 49
Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp 
1               5                   10                  15      


Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp 
            20                  25                  30          


Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr 
        35                  40                  45              


Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln 
    50                  55                  60                  


Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly 
65                  70                  75                  80  


Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn 
                85                  90                  95      


Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser 
            100                 105                 110         


Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu 
        115                 120                 125             


Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln 
    130                 135                 140                 


Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile 
145                 150                 155                 160 


Ser Trp Pro Ser Val Ser Tyr Lys 
                165             


<210> 50
<211> 167
<212> PRT
<213> Vibrio cholera

<400> 50
Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val 
1               5                   10                  15      


Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu 
            20                  25                  30          


Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile 
        35                  40                  45              


Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp 
    50                  55                  60                  


Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr 
65                  70                  75                  80  


Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp 
                85                  90                  95      


Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val 
            100                 105                 110         


Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr 
        115                 120                 125             


Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly 
    130                 135                 140                 


Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser 
145                 150                 155                 160 


Trp Pro Ser Val Ser Tyr Lys 
                165         


<210> 51
<211> 166
<212> PRT
<213> Vibrio cholera

<400> 51
Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val 
1               5                   10                  15      


Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln 
            20                  25                  30          


Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly 
        35                  40                  45              


Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala 
    50                  55                  60                  


Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys 
65                  70                  75                  80  


Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu 
                85                  90                  95      


Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp 
            100                 105                 110         


Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser 
        115                 120                 125             


Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn 
    130                 135                 140                 


Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp 
145                 150                 155                 160 


Pro Ser Val Ser Tyr Lys 
                165     


<210> 52
<211> 165
<212> PRT
<213> Vibrio cholera

<400> 52
Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu 
1               5                   10                  15      


Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn 
            20                  25                  30          


Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu 
        35                  40                  45              


Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro 
    50                  55                  60                  


Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val 
                85                  90                  95      


Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu 
            100                 105                 110         


Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile 
        115                 120                 125             


Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val 
    130                 135                 140                 


Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro 
145                 150                 155                 160 


Ser Val Ser Tyr Lys 
                165 


<210> 53
<211> 164
<212> PRT
<213> Vibrio cholera

<400> 53
Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp 
1               5                   10                  15      


Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp 
            20                  25                  30          


Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe 
        35                  40                  45              


Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe 
    50                  55                  60                  


Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr 
65                  70                  75                  80  


Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro 
                85                  90                  95      


Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu 
            100                 105                 110         


Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp 
        115                 120                 125             


Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser 
    130                 135                 140                 


Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser 
145                 150                 155                 160 


Val Ser Tyr Lys 
                


<210> 54
<211> 163
<212> PRT
<213> Vibrio cholera

<400> 54
Pro Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu 
1               5                   10                  15      


Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile 
            20                  25                  30          


Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala 
        35                  40                  45              


Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly 
    50                  55                  60                  


Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser 
65                  70                  75                  80  


Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile 
                85                  90                  95      


Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp 
            100                 105                 110         


Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu 
        115                 120                 125             


Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe 
    130                 135                 140                 


Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val 
145                 150                 155                 160 


Ser Tyr Lys 
            


<210> 55
<211> 162
<212> PRT
<213> Vibrio cholera

<400> 55
Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly 
1               5                   10                  15      


Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys 
            20                  25                  30          


Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr 
        35                  40                  45              


Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val 
    50                  55                  60                  


Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr 
65                  70                  75                  80  


Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly 
                85                  90                  95      


Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln 
            100                 105                 110         


Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp 
        115                 120                 125             


Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser 
    130                 135                 140                 


Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser 
145                 150                 155                 160 


Tyr Lys 
        


<210> 56
<211> 161
<212> PRT
<213> Vibrio cholera

<400> 56
Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val 
1               5                   10                  15      


Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp 
            20                  25                  30          


Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val 
        35                  40                  45              


Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile 
    50                  55                  60                  


His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn 
65                  70                  75                  80  


Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu 
                85                  90                  95      


Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln 
            100                 105                 110         


Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn 
        115                 120                 125             


Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val 
    130                 135                 140                 


Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr 
145                 150                 155                 160 


Lys 
    


<210> 57
<211> 160
<212> PRT
<213> Vibrio cholera

<400> 57
Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu 
1               5                   10                  15      


Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu 
            20                  25                  30          


Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg 
        35                  40                  45              


Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His 
    50                  55                  60                  


Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg 
65                  70                  75                  80  


Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp 
                85                  90                  95      


Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg 
            100                 105                 110         


Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln 
        115                 120                 125             


Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr 
    130                 135                 140                 


Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
145                 150                 155                 160 


<210> 58
<211> 159
<212> PRT
<213> Vibrio cholera

<400> 58
Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr 
1               5                   10                  15      


Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp 
            20                  25                  30          


Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala 
        35                  40                  45              


Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu 
    50                  55                  60                  


Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys 
65                  70                  75                  80  


Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser 
                85                  90                  95      


Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn 
            100                 105                 110         


Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr 
        115                 120                 125             


Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg 
    130                 135                 140                 


Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
145                 150                 155                 


<210> 59
<211> 158
<212> PRT
<213> Vibrio cholera

<400> 59
Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr 
1               5                   10                  15      


Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys 
            20                  25                  30          


Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr 
        35                  40                  45              


Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp 
    50                  55                  60                  


Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu 
65                  70                  75                  80  


Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro 
                85                  90                  95      


Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile 
            100                 105                 110         


Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu 
        115                 120                 125             


Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro 
    130                 135                 140                 


Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
145                 150                 155             


<210> 60
<211> 157
<212> PRT
<213> Vibrio cholera

<400> 60
Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser 
1               5                   10                  15      


Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly 
            20                  25                  30          


Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg 
        35                  40                  45              


His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile 
    50                  55                  60                  


Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly 
65                  70                  75                  80  


Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala 
                85                  90                  95      


Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile 
            100                 105                 110         


Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu 
        115                 120                 125             


Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu 
    130                 135                 140                 


His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
145                 150                 155         


<210> 61
<211> 156
<212> PRT
<213> Vibrio cholera

<400> 61
Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
1               5                   10                  15      


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
            20                  25                  30          


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
        35                  40                  45              


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
    50                  55                  60                  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
65                  70                  75                  80  


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
                85                  90                  95      


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
            100                 105                 110         


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
        115                 120                 125             


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
    130                 135                 140                 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
145                 150                 155     


<210> 62
<211> 155
<212> PRT
<213> Vibrio cholera

<400> 62
Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
1               5                   10                  15      


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
            20                  25                  30          


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
        35                  40                  45              


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
    50                  55                  60                  


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
65                  70                  75                  80  


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
                85                  90                  95      


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
            100                 105                 110         


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
        115                 120                 125             


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
    130                 135                 140                 


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
145                 150                 155 


<210> 63
<211> 154
<212> PRT
<213> Vibrio cholera

<400> 63
Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
1               5                   10                  15      


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
            20                  25                  30          


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
        35                  40                  45              


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
    50                  55                  60                  


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
65                  70                  75                  80  


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
                85                  90                  95      


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
            100                 105                 110         


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
        115                 120                 125             


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
    130                 135                 140                 


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys 
145                 150                 


<210> 64
<211> 153
<212> PRT
<213> Vibrio cholera

<400> 64
Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn 
1               5                   10                  15      


Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile 
            20                  25                  30          


Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn 
        35                  40                  45              


Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn 
    50                  55                  60                  


Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile 
65                  70                  75                  80  


Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile 
                85                  90                  95      


Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys 
            100                 105                 110         


Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr 
        115                 120                 125             


Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala 
    130                 135                 140                 


Ile Ser Trp Pro Ser Val Ser Tyr Lys 
145                 150             


<210> 65
<211> 152
<212> PRT
<213> Vibrio cholera

<400> 65
Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp 
1               5                   10                  15      


Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr 
            20                  25                  30          


Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln 
        35                  40                  45              


Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly 
    50                  55                  60                  


Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn 
65                  70                  75                  80  


Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser 
                85                  90                  95      


Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu 
            100                 105                 110         


Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln 
        115                 120                 125             


Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile 
    130                 135                 140                 


Ser Trp Pro Ser Val Ser Tyr Lys 
145                 150         


<210> 66
<211> 151
<212> PRT
<213> Vibrio cholera

<400> 66
Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu 
1               5                   10                  15      


Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile 
            20                  25                  30          


Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp 
        35                  40                  45              


Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr 
    50                  55                  60                  


Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp 
65                  70                  75                  80  


Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val 
                85                  90                  95      


Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr 
            100                 105                 110         


Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly 
        115                 120                 125             


Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser 
    130                 135                 140                 


Trp Pro Ser Val Ser Tyr Lys 
145                 150     


<210> 67
<211> 150
<212> PRT
<213> Vibrio cholera

<400> 67
Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln 
1               5                   10                  15      


Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly 
            20                  25                  30          


Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala 
        35                  40                  45              


Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys 
    50                  55                  60                  


Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu 
65                  70                  75                  80  


Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp 
                85                  90                  95      


Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser 
            100                 105                 110         


Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn 
        115                 120                 125             


Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp 
    130                 135                 140                 


Pro Ser Val Ser Tyr Lys 
145                 150 


<210> 68
<211> 149
<212> PRT
<213> Vibrio cholera

<400> 68
Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn 
1               5                   10                  15      


Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu 
            20                  25                  30          


Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro 
        35                  40                  45              


Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr 
    50                  55                  60                  


Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val 
65                  70                  75                  80  


Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu 
                85                  90                  95      


Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile 
            100                 105                 110         


Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val 
        115                 120                 125             


Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro 
    130                 135                 140                 


Ser Val Ser Tyr Lys 
145                 


<210> 69
<211> 148
<212> PRT
<213> Vibrio cholera

<400> 69
Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp 
1               5                   10                  15      


Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe 
            20                  25                  30          


Ala Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe 
        35                  40                  45              


Gly Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr 
    50                  55                  60                  


Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro 
65                  70                  75                  80  


Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu 
                85                  90                  95      


Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp 
            100                 105                 110         


Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser 
        115                 120                 125             


Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser 
    130                 135                 140                 


Val Ser Tyr Lys 
145             


<210> 70
<211> 147
<212> PRT
<213> Vibrio cholera

<400> 70
Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile 
1               5                   10                  15      


Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala 
            20                  25                  30          


Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly 
        35                  40                  45              


Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser 
    50                  55                  60                  


Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile 
65                  70                  75                  80  


Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp 
                85                  90                  95      


Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu 
            100                 105                 110         


Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe 
        115                 120                 125             


Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val 
    130                 135                 140                 


Ser Tyr Lys 
145         


<210> 71
<211> 185
<212> PRT
<213> Vibrio cholera

<400> 71
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr 
            180                 185 


<210> 72
<211> 184
<212> PRT
<213> Vibrio cholera

<400> 72
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser 
            180                 


<210> 73
<211> 183
<212> PRT
<213> Vibrio cholera

<400> 73
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val 
            180             


<210> 74
<211> 182
<212> PRT
<213> Vibrio cholera

<400> 74
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser 
            180         


<210> 75
<211> 181
<212> PRT
<213> Vibrio cholera

<400> 75
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro 
            180     


<210> 76
<211> 180
<212> PRT
<213> Vibrio cholera

<400> 76
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp 
            180 


<210> 77
<211> 179
<212> PRT
<213> Vibrio cholera

<400> 77
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser 
            


<210> 78
<211> 178
<212> PRT
<213> Vibrio cholera

<400> 78
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile 
        


<210> 79
<211> 177
<212> PRT
<213> Vibrio cholera

<400> 79
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala 
    


<210> 80
<211> 176
<212> PRT
<213> Vibrio cholera

<400> 80
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


<210> 81
<211> 175
<212> PRT
<213> Vibrio cholera

<400> 81
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175 


<210> 82
<211> 174
<212> PRT
<213> Vibrio cholera

<400> 82
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
                165                 170                 


<210> 83
<211> 173
<212> PRT
<213> Vibrio cholera

<400> 83
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu 
                165                 170             


<210> 84
<211> 172
<212> PRT
<213> Vibrio cholera

<400> 84
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro 
                165                 170         


<210> 85
<211> 171
<212> PRT
<213> Vibrio cholera

<400> 85
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg 
                165                 170     


<210> 86
<211> 170
<212> PRT
<213> Vibrio cholera

<400> 86
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr 
                165                 170 


<210> 87
<211> 169
<212> PRT
<213> Vibrio cholera

<400> 87
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val 
                165                 


<210> 88
<211> 168
<212> PRT
<213> Vibrio cholera

<400> 88
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser 
                165             


<210> 89
<211> 167
<212> PRT
<213> Vibrio cholera

<400> 89
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe 
                165         


<210> 90
<211> 166
<212> PRT
<213> Vibrio cholera

<400> 90
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser 
                165     


<210> 91
<211> 165
<212> PRT
<213> Vibrio cholera

<400> 91
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val 
                165 


<210> 92
<211> 164
<212> PRT
<213> Vibrio cholera

<400> 92
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn 
                


<210> 93
<211> 163
<212> PRT
<213> Vibrio cholera

<400> 93
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly 
            


<210> 94
<211> 162
<212> PRT
<213> Vibrio cholera

<400> 94
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln 
        


<210> 95
<211> 161
<212> PRT
<213> Vibrio cholera

<400> 95
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr 
    


<210> 96
<211> 160
<212> PRT
<213> Vibrio cholera

<400> 96
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


<210> 97
<211> 159
<212> PRT
<213> Vibrio cholera

<400> 97
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 


<210> 98
<211> 158
<212> PRT
<213> Vibrio cholera

<400> 98
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
145                 150                 155             


<210> 99
<211> 157
<212> PRT
<213> Vibrio cholera

<400> 99
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu 
145                 150                 155         


<210> 100
<211> 156
<212> PRT
<213> Vibrio cholera

<400> 100
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu 
145                 150                 155     


<210> 101
<211> 155
<212> PRT
<213> Vibrio cholera

<400> 101
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr 
145                 150                 155 


<210> 102
<211> 154
<212> PRT
<213> Vibrio cholera

<400> 102
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln 
145                 150                 


<210> 103
<211> 153
<212> PRT
<213> Vibrio cholera

<400> 103
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn 
145                 150             


<210> 104
<211> 152
<212> PRT
<213> Vibrio cholera

<400> 104
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp 
145                 150         


<210> 105
<211> 151
<212> PRT
<213> Vibrio cholera

<400> 105
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu 
145                 150     


<210> 106
<211> 150
<212> PRT
<213> Vibrio cholera

<400> 106
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp 
145                 150 


<210> 107
<211> 151
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 107
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp 
145                 150     


<210> 108
<211> 149
<212> PRT
<213> Vibrio cholera

<400> 108
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile 
145                 


<210> 109
<211> 148
<212> PRT
<213> Vibrio cholera

<400> 109
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser 
145             


<210> 110
<211> 147
<212> PRT
<213> Vibrio cholera

<400> 110
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr 
145         


<210> 111
<211> 146
<212> PRT
<213> Vibrio cholera

<400> 111
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu 
145     


<210> 112
<211> 145
<212> PRT
<213> Vibrio cholera

<400> 112
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys 
145 


<210> 113
<211> 144
<212> PRT
<213> Vibrio cholera

<400> 113
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


<210> 114
<211> 143
<212> PRT
<213> Vibrio cholera

<400> 114
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140             


<210> 115
<211> 142
<212> PRT
<213> Vibrio cholera

<400> 115
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
    130                 135                 140         


<210> 116
<211> 141
<212> PRT
<213> Vibrio cholera

<400> 116
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile 
    130                 135                 140     


<210> 117
<211> 140
<212> PRT
<213> Vibrio cholera

<400> 117
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile 
    130                 135                 140 


<210> 118
<211> 139
<212> PRT
<213> Vibrio cholera

<400> 118
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn 
    130                 135                 


<210> 119
<211> 138
<212> PRT
<213> Vibrio cholera

<400> 119
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg 
    130                 135             


<210> 120
<211> 137
<212> PRT
<213> Vibrio cholera

<400> 120
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln 
    130                 135         


<210> 121
<211> 136
<212> PRT
<213> Vibrio cholera

<400> 121
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln 
    130                 135     


<210> 122
<211> 135
<212> PRT
<213> Vibrio cholera

<400> 122
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp 
    130                 135 


<210> 123
<211> 134
<212> PRT
<213> Vibrio cholera

<400> 123
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu 
    130                 


<210> 124
<211> 133
<212> PRT
<213> Vibrio cholera

<400> 124
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu 
    130             


<210> 125
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 125
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu 
    130                 


<210> 126
<211> 121
<212> PRT
<213> Vibrio cholera

<400> 126
Gly Asn Ala Met Ser Ala Leu Ala Ala His Arg Val Cys Gly Val Pro 
1               5                   10                  15      


Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp 
            20                  25                  30          


Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala 
        35                  40                  45              


Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu 
    50                  55                  60                  


Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Asp Leu Arg Arg 
65                  70                  75                  80  


Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu Thr Val Ala 
                85                  90                  95      


Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly Leu Thr Pro 
            100                 105                 110         


Glu Gln Thr Ser Ala Gly Ala Gln Ala 
        115                 120     


<210> 127
<211> 39
<212> PRT
<213> Vibrio cholera

<400> 127
Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val 
1               5                   10                  15      


Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly 
            20                  25                  30          


Arg Ser Tyr Leu Pro Glu Asn 
        35                  


<210> 128
<211> 209
<212> PRT
<213> Vibrio cholera

<400> 128
Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu 
1               5                   10                  15      


Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val 
            20                  25                  30          


Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg 
        35                  40                  45              


Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp 
    50                  55                  60                  


Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala 
65                  70                  75                  80  


Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu 
                85                  90                  95      


Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser 
            100                 105                 110         


Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu 
        115                 120                 125             


His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala 
    130                 135                 140                 


Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly 
145                 150                 155                 160 


Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr Ile Pro Gly 
                165                 170                 175     


Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val Ala Lys Glu 
            180                 185                 190         


Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys Asp Glu Leu 
        195                 200                 205             


Lys 
    


<210> 129
<211> 425
<212> PRT
<213> Vibrio cholera

<400> 129
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn 
            420                 425 


<210> 130
<211> 415
<212> PRT
<213> Vibrio cholera

<400> 130
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser 
                405                 410                 415 


<210> 131
<211> 397
<212> PRT
<213> Vibrio cholera

<400> 131
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala 
385                 390                 395         


<210> 132
<211> 386
<212> PRT
<213> Vibrio cholera

<400> 132
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala 
385     


<210> 133
<211> 291
<212> PRT
<213> Vibrio cholera

<400> 133
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro 
    290     


<210> 134
<211> 1902
<212> DNA
<213> Vibrio cholera

<400> 134
gtcgaagaag ctttaaacat ctttgatgaa tgccgttcgc catgttcgtt gaccccggaa       60

ccgggtaagc cgattcaatc aaaactgtct atccctagtg atgttgttct ggatgaaggt      120

gttctgtatt actcgatgac gattaatgat gagcagaatg atattaagga tgaggacaaa      180

ggcgagtcca ttatcactat tggtgaattt gccacagtac gcgcgactag acattatgtt      240

aatcaagatg cgccttttgg tgtcatccat ttagatatta cgacagaaaa tggtacaaaa      300

acgtactctt ataaccgcaa agagggtgaa tttgcaatca attggttagt gcctattggt      360

gaagattctc ctgcaagcat caaaatctcc gttgatgagc tcgatcagca acgcaatatc      420

atcgaggtgc ctaaactgta tagtattgat ctcgataacc aaacgttaga gcagtggaaa      480

acccaaggta atgtttcttt ttcggtaacg cgtcctgaac ataatatcgc tatctcttgg      540

ccaagcgtga gttacaaagc agcgcagaaa gagggttcac gccataagcg ttgggctcat      600

tggcatacag gcttagcact gtgttggctt gtgccaatgg atgctatcta taactatatc      660

acccagcaaa attgtacttt aggggataat tggtttggtg gctcttatga gactgttgca      720

ggcactccga aggtgattac ggttaagcaa gggattgaac aaaagccagt tgagcagcgc      780

atccatttct ccaaggggaa tgcgatgagc gcacttgctg ctcatcgcgt ctgtggtgtg      840

ccattagaaa ctttggcgcg cagtcgcaaa cctcgtgatc tgacggatga tttatcatgt      900

gcctatcaag cgcagaatat cgtgagttta tttgtcgcga cgcgtatcct gttctctcat      960

ctggatagcg tatttactct gaatcttgac gaacaagaac cagaggtggc tgaacgtcta     1020

agtgatcttc gccgtatcaa tgaaaataac ccgggcatgg ttacacaggt tttaaccgtt     1080

gctcgtcaga tctataacga ttatgtcact caccatccgg gcttaactcc tgagcaaacc     1140

agtgcgggtg cacaagctgc cgatatcctc tctttatttt gcccagatgc tgataagtct     1200

tgtgtggctt caaacaacga tcaagccaat atcaacatcg agtctcgttc tggccgttca     1260

tatttgcctg aaaaccgtgc ggtaatcacc cctcaaggcg tcacaaattg gacttaccag     1320

gaactcgaag caacacatca agctctgact cgtgagggtt atgtgttcgt gggttaccat     1380

ggtacgaatc atgtcgctgc gcaaaccatc gtgaatcgca ttgcccctgt tccgcgcggc     1440

aacaacactg aaaacgagga aaagtggggc gggttatatg ttgcaactca cgctgaagtt     1500

gcccatggtt atgctcgcat caaagaaggg acaggggagt atggccttcc gacccgtgct     1560

gagcgcgacg ctcgtggggt aatgctgcgc gtgtatatcc ctcgtgcttc attagaacgt     1620

ttttatcgca cgaatacacc tttggaaaat gctgaggagc atatcacgca agtgattggt     1680

cattctttgc cattacgcaa tgaagcattt actggtccag aaagtgcggg cggggaagac     1740

gaaactgtca ttggctggga tatggcgatt catgcagttg cgatcccttc gactatccca     1800

gggaacgctt acgaagaatt ggcgattgat gaggaggctg ttgcaaaaga gcaatcgatt     1860

agcacaaaac caccttataa agagcgcaaa gatgaactta ag                        1902


<210> 135
<211> 613
<212> PRT
<213> Pseudomonas aeruginosa

<400> 135
Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Ala Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp 
    370                 375                 380                 


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
385                 390                 395                 400 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
                405                 410                 415     


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
        435                 440                 445             


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
    450                 455                 460                 


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
465                 470                 475                 480 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
                485                 490                 495     


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
            500                 505                 510         


Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
        515                 520                 525             


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
    530                 535                 540                 


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
545                 550                 555                 560 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
                565                 570                 575     


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
            580                 585                 590         


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
        595                 600                 605             


Arg Glu Asp Leu Lys 
    610             


<210> 136
<211> 1839
<212> DNA
<213> Pseudomonas aeruginosa

<400> 136
gccgaggaag ccttcgacct ctggaacgaa tgcgccaagg cctgcgtgct cgacctcaag       60

gacggcgtgc gttccagccg catgagcgtc gacccggcca tcgccgacac caacggccag      120

ggcgtgctgc actactccat ggtcctggag ggcggcaacg acgcgctcaa gctggccatc      180

gacaacgccc tcagcatcac cagcgacggc ctgaccatcc gcctcgaagg tggcgtcgag      240

ccgaacaagc cggtgcgcta cagctacacg cgccaggcgc gcggcagttg gtcgctgaac      300

tggctggtgc cgatcggcca cgagaagcct tcgaacatca aggtgttcat ccacgaactg      360

aacgccggta accagctcag ccacatgtcg ccgatctaca ccatcgagat gggcgacgag      420

ttgctggcga agctggcgcg cgatgccacc ttcttcgtca gggcgcacga gagcaacgag      480

atgcagccga cgctcgccat cagccatgcc ggggtcagcg tggtcatggc ccaggcccag      540

ccgcgccggg aaaagcgctg gagcgaatgg gccagcggca aggtgttgtg cctgctcgac      600

ccgctggacg gggtctacaa ctacctcgcc cagcagcgct gcaacctcga cgatacctgg      660

gaaggcaaga tctaccgggt gctcgccggc aacccggcga agcatgacct ggacatcaag      720

cccacggtca tcagtcatcg cctgcatttc cccgagggcg gcagcctggc cgcgctgacc      780

gcgcaccagg cctgccacct gccgctggag accttcaccc gtcatcgcca gccgcgcggc      840

tgggaacaac tggagcagtg cggctatccg gtgcagcggc tggtcgccct ctacctggcg      900

gcgcggctgt cgtggaacca ggtcgaccag gtgatccgca acgccctggc cagccccggc      960

agcggcggcg acctgggcga agcgatccgc gagcagccgg agcaggcccg tctggccctg     1020

accctggccg ccgccgagag cgagcgcttc gtccggcagg gcacaggcaa cgacgaggcc     1080

ggcgcggcca gcgccgacgt ggtgagcctg acctgcccgg tcgccgccgg tgaatgcgcg     1140

ggcccggcgg acagcggcga cgccctgctg gagcgcaact atcccactgg cgcggagttc     1200

ctcggcgacg gcggcgacat cagcttcagc acccgcggca cgcagaactg gacggtggag     1260

cggctgctcc aggcgcaccg ccaactggag gagcgcggct atgtgttcgt cggctaccac     1320

ggcaccttcc tcgaagcggc gcaaagcatc gtcttcggcg gggtgcgcgc gcgcagccag     1380

gacctcgacg cgatctggcg cggtttctat atcgccggcg atccggcgct ggcctacggc     1440

tacgcccagg accaggaacc cgacgcgcgc ggccggatcc gcaacggtgc cctgctgcgg     1500

gtctatgtgc cgcgctcgag tctgccgggc ttctaccgca ccggcctgac cctggccgcg     1560

ccggaggcgg cgggcgaggt cgaacggctg atcggccatc cgctgccgct gcgcctggac     1620

gccatcaccg gccccgagga ggaaggcggg cgcctggaaa ccattctcgg ctggccgctg     1680

gccgagcgca ccgtggtgat tccctcggcg atccccaccg acccgcgcaa cgtcggcggc     1740

gacctcgacc cgtccagcat ccccgacaag gaacaggcga tcagcgccct gccggactac     1800

gccagccagc ccggcaaacc gccgcgcgag gacctgaag                            1839


<210> 137
<211> 252
<212> PRT
<213> Pseudomonas aeruginosa

<400> 137
Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Ala Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu 
                245                 250         


<210> 138
<211> 112
<212> PRT
<213> Pseudomonas aeruginosa

<400> 138
Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
1               5                   10                  15      


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            20                  25                  30          


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    50                  55                  60                  


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
65                  70                  75                  80  


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                85                  90                  95      


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser 
            100                 105                 110         


<210> 139
<211> 40
<212> PRT
<213> Pseudomonas aeruginosa

<400> 139
Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala 
1               5                   10                  15      


Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr 
            20                  25                  30          


Gly Ala Glu Phe Leu Gly Asp Gly 
        35                  40  


<210> 140
<211> 209
<212> PRT
<213> Pseudomonas aeruginosa

<400> 140
Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu 
1               5                   10                  15      


Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe 
            20                  25                  30          


Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe 
        35                  40                  45              


Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly 
    50                  55                  60                  


Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp 
65                  70                  75                  80  


Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg 
                85                  90                  95      


Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Gly Leu 
            100                 105                 110         


Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly 
        115                 120                 125             


His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu 
    130                 135                 140                 


Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr 
145                 150                 155                 160 


Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly 
                165                 170                 175     


Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala 
            180                 185                 190         


Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu 
        195                 200                 205             


Lys 
    


<210> 141
<211> 404
<212> PRT
<213> Pseudomonas aeruginosa

<400> 141
Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Ala Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp 
    370                 375                 380                 


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
385                 390                 395                 400 


Leu Gly Asp Gly 
                


<210> 142
<211> 395
<212> PRT
<213> Pseudomonas aeruginosa

<400> 142
Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Ala Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp 
    370                 375                 380                 


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
385                 390                 395 


<210> 143
<211> 375
<212> PRT
<213> Pseudomonas aeruginosa

<400> 143
Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Ala Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala 
    370                 375 


<210> 144
<211> 364
<212> PRT
<213> Pseudomonas aeruginosa

<400> 144
Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Ala Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser 
        355                 360                 


<210> 145
<211> 277
<212> PRT
<213> Pseudomonas aeruginosa

<400> 145
Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Ala Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln 
        275         


<210> 146
<211> 627
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 146
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Ser Leu Ala 
            260                 265                 270         


Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr 
        275                 280                 285             


Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr 
    290                 295                 300                 


Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp 
305                 310                 315                 320 


Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser 
                325                 330                 335     


Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg 
            340                 345                 350         


Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln 
        355                 360                 365             


Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Ala Asp Val Val Ser 
    370                 375                 380                 


Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser 
385                 390                 395                 400 


Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu 
                405                 410                 415     


Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp 
            420                 425                 430         


Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly 
        435                 440                 445             


Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser 
    450                 455                 460                 


Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile 
465                 470                 475                 480 


Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr 
                485                 490                 495     


Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala 
            500                 505                 510         


Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg 
        515                 520                 525             


Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg 
    530                 535                 540                 


Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro 
545                 550                 555                 560 


Glu Glu Glu Gly Gly Arg Leu Thr Ile Leu Gly Trp Pro Leu Ala Glu 
                565                 570                 575     


Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val 
            580                 585                 590         


Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile 
        595                 600                 605             


Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu 
    610                 615                 620                 


Asp Leu Lys 
625         


<210> 147
<211> 620
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 147
Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met 
        35                  40                  45              


Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala 
    50                  55                  60                  


Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val 
65                  70                  75                  80  


Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly 
                85                  90                  95      


Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser 
            100                 105                 110         


Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser 
        115                 120                 125             


His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala 
    130                 135                 140                 


Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn 
145                 150                 155                 160 


Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val 
                165                 170                 175     


Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala 
            180                 185                 190         


Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn 
        195                 200                 205             


Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys 
    210                 215                 220                 


Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile 
225                 230                 235                 240 


Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Asn 
                245                 250                 255     


Ala Met Ser Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu 
            260                 265                 270         


Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser 
        275                 280                 285             


Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg 
    290                 295                 300                 


Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu 
305                 310                 315                 320 


Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn 
                325                 330                 335     


Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln 
            340                 345                 350         


Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln 
        355                 360                 365             


Thr Ser Ala Gly Ala Gln Ala Ala Glu Ile Leu Ser Leu Phe Cys Pro 
    370                 375                 380                 


Asp Ala Asp Lys Ser Cys Val Ala Thr Asn Asn Asp Gln Ala Asn Ile 
385                 390                 395                 400 


Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala 
                405                 410                 415     


Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu 
            420                 425                 430         


Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr 
        435                 440                 445             


Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val 
    450                 455                 460                 


Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr 
465                 470                 475                 480 


Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu 
                485                 490                 495     


Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg 
            500                 505                 510         


Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe 
        515                 520                 525             


Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln 
    530                 535                 540                 


Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro 
545                 550                 555                 560 


Glu Ser Ala Gly Gly Glu Asp Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu 
            580                 585                 590         


Leu Ala Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr 
        595                 600                 605             


Lys Pro Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
    610                 615                 620 


<210> 148
<211> 18
<212> PRT
<213> Vibrio cholera

<400> 148
Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser 
1               5                   10                  15      


Ile Asp 
        


<210> 149
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 149
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp 
        35                  


<210> 150
<211> 38
<212> PRT
<213> Vibrio cholera

<400> 150
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp 
        35              


<210> 151
<211> 37
<212> PRT
<213> Vibrio cholera

<400> 151
Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val 
1               5                   10                  15      


Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro 
            20                  25                  30          


Ser Val Ser Tyr Lys 
        35          


<210> 152
<211> 22
<212> PRT
<213> Vibrio cholera

<400> 152
Lys Ala Ala Gln Lys Glu Gly Ser Arg His Lys Arg Trp Ala His Trp 
1               5                   10                  15      


His Thr Gly Leu Ala Leu 
            20          


<210> 153
<211> 593
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 153
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met 
                405                 410                 415     


Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu 
            420                 425                 430         


Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln 
        435                 440                 445             


Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser 
    450                 455                 460                 


Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile 
465                 470                 475                 480 


Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg 
                485                 490                 495     


Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val 
            500                 505                 510         


Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly 
        515                 520                 525             


Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr 
    530                 535                 540                 


Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys 
545                 550                 555                 560 


Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu 
                565                 570                 575     


Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly 
            580                 585                 590         


Phe 
    


<210> 154
<211> 580
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 154
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr 
                405                 410                 415     


Gly Val Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys 
            420                 425                 430         


Thr His Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp 
        435                 440                 445             


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp 
    450                 455                 460                 


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
465                 470                 475                 480 


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
                485                 490                 495     


Met Pro Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn 
            500                 505                 510         


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
        515                 520                 525             


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val 
    530                 535                 540                 


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
545                 550                 555                 560 


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met 
                565                 570                 575     


Lys Ile Arg Asn 
            580 


<210> 155
<211> 460
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 155
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala Ala Leu Gln Lys Ser 
        275                 280                 285             


Val Ser Ser Phe Leu Met Gly Thr Leu Ala Thr Ser Cys Leu Leu Leu 
    290                 295                 300                 


Leu Ala Leu Leu Val Gln Gly Gly Ala Ala Ala Pro Ile Ser Ser His 
305                 310                 315                 320 


Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg 
                325                 330                 335     


Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp 
            340                 345                 350         


Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu 
        355                 360                 365             


Arg Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val 
    370                 375                 380                 


Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val 
385                 390                 395                 400 


Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu 
                405                 410                 415     


Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr 
            420                 425                 430         


Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu 
        435                 440                 445             


Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
    450                 455                 460 


<210> 156
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 156
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Met Arg Ser Ser Lys Asn 
            260                 265                 270         


Val Ile Lys Glu Phe Met Arg Phe Lys Val Arg Met Glu Gly Thr Val 
        275                 280                 285             


Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr 
    290                 295                 300                 


Glu Gly His Asn Thr Val Lys Leu Lys Val Thr Lys Gly Gly Pro Leu 
305                 310                 315                 320 


Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Gln Tyr Gly Ser Lys 
                325                 330                 335     


Val Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Lys Lys Leu Ser 
            340                 345                 350         


Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly 
        355                 360                 365             


Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Cys Phe 
    370                 375                 380                 


Ile Tyr Lys Val Lys Phe Ile Gly Val Asn Phe Pro Ser Asp Gly Pro 
385                 390                 395                 400 


Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu Arg Leu 
                405                 410                 415     


Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu Ile His Lys Ala Leu Lys 
            420                 425                 430         


Leu Lys Asp Gly Gly His Tyr Leu Val Glu Phe Lys Ser Ile Tyr Met 
        435                 440                 445             


Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr Tyr Tyr Val Asp Ser Lys 
    450                 455                 460                 


Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr 
465                 470                 475                 480 


Glu Arg Thr Glu Gly Arg His His Leu Phe Leu 
                485                 490     


<210> 157
<211> 859
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 157
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Ala Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys Met Arg Ser Ser Lys Asn 
625                 630                 635                 640 


Val Ile Lys Glu Phe Met Arg Phe Lys Val Arg Met Glu Gly Thr Val 
                645                 650                 655     


Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr 
            660                 665                 670         


Glu Gly His Asn Thr Val Lys Leu Lys Val Thr Lys Gly Gly Pro Leu 
        675                 680                 685             


Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Gln Tyr Gly Ser Lys 
    690                 695                 700                 


Val Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Lys Lys Leu Ser 
705                 710                 715                 720 


Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly 
                725                 730                 735     


Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Cys Phe 
            740                 745                 750         


Ile Tyr Lys Val Lys Phe Ile Gly Val Asn Phe Pro Ser Asp Gly Pro 
        755                 760                 765             


Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu Arg Leu 
    770                 775                 780                 


Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu Ile His Lys Ala Leu Lys 
785                 790                 795                 800 


Leu Lys Asp Gly Gly His Tyr Leu Val Glu Phe Lys Ser Ile Tyr Met 
                805                 810                 815     


Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr Tyr Tyr Val Asp Ser Lys 
            820                 825                 830         


Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr 
        835                 840                 845             


Glu Arg Thr Glu Gly Arg His His Leu Phe Leu 
    850                 855                 


<210> 158
<211> 340
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 158
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp 
145                 150                 155                 160 


Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr 
                165                 170                 175     


Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser 
            180                 185                 190         


Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro 
        195                 200                 205             


Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu 
    210                 215                 220                 


Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln 
225                 230                 235                 240 


Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp 
                245                 250                 255     


Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr 
            260                 265                 270         


Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe 
        275                 280                 285             


Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp 
305                 310                 315                 320 


Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly 
                325                 330                 335     


Ser Cys Gly Phe 
            340 


<210> 159
<211> 357
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 159
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe 
                165                 170                 175     


Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp 
            180                 185                 190         


Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr 
        195                 200                 205             


Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile 
    210                 215                 220                 


Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu 
225                 230                 235                 240 


Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val 
                245                 250                 255     


Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser 
            260                 265                 270         


Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln 
        275                 280                 285             


Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile 
    290                 295                 300                 


Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp 
305                 310                 315                 320 


Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met 
                325                 330                 335     


Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu 
            340                 345                 350         


Gly Ser Cys Gly Phe 
        355         


<210> 160
<211> 393
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 160
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Gly Gly Gly Gly Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Pro Thr Ile Pro Leu 
        195                 200                 205             


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
    210                 215                 220                 


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
225                 230                 235                 240 


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
                245                 250                 255     


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
            260                 265                 270         


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
        275                 280                 285             


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
    290                 295                 300                 


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
305                 310                 315                 320 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
                325                 330                 335     


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
            340                 345                 350         


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
        355                 360                 365             


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
    370                 375                 380                 


Arg Ser Val Glu Gly Ser Cys Gly Phe 
385                 390             


<210> 161
<211> 412
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 161
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Gly Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Pro Thr 
    210                 215                 220                 


Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg 
225                 230                 235                 240 


Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr 
                245                 250                 255     


Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser 
            260                 265                 270         


Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr 
        275                 280                 285             


Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile 
    290                 295                 300                 


Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn 
305                 310                 315                 320 


Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys 
                325                 330                 335     


Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly 
            340                 345                 350         


Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp 
        355                 360                 365             


Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu 
    370                 375                 380                 


Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile 
385                 390                 395                 400 


Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
                405                 410         


<210> 162
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 162
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn 
            260                 265                 270         


Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr 
        275                 280                 285             


Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe 
    290                 295                 300                 


Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr 
305                 310                 315                 320 


Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu 
                325                 330                 335     


Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe 
            340                 345                 350         


Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser 
        355                 360                 365             


Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu 
    370                 375                 380                 


Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys 
385                 390                 395                 400 


Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu 
                405                 410                 415     


Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys 
            420                 425                 430         


Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser 
        435                 440                 445             


Cys Gly Phe 
    450     


<210> 163
<211> 457
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 163
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Pro Thr Ile Pro Leu 
            260                 265                 270         


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        275                 280                 285             


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    290                 295                 300                 


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
305                 310                 315                 320 


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                325                 330                 335     


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            340                 345                 350         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        355                 360                 365             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    370                 375                 380                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
385                 390                 395                 400 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                405                 410                 415     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            420                 425                 430         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        435                 440                 445             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    450                 455         


<210> 164
<211> 472
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 164
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Pro Thr Ile Pro Leu Ser 
        275                 280                 285             


Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu 
    290                 295                 300                 


Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu 
305                 310                 315                 320 


Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser 
                325                 330                 335     


Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser 
            340                 345                 350         


Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu 
        355                 360                 365             


Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr 
    370                 375                 380                 


Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu 
385                 390                 395                 400 


Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr 
                405                 410                 415     


Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His 
            420                 425                 430         


Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg 
        435                 440                 445             


Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg 
    450                 455                 460                 


Ser Val Glu Gly Ser Cys Gly Phe 
465                 470         


<210> 165
<211> 354
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 165
Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile 
1               5                   10                  15      


Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala 
            20                  25                  30          


Thr Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly 
        35                  40                  45              


Val Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser 
    50                  55                  60                  


Tyr Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile 
65                  70                  75                  80  


Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp 
                85                  90                  95      


Gln Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu 
            100                 105                 110         


Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe 
        115                 120                 125             


Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val 
    130                 135                 140                 


Ser Tyr Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala 
                165                 170                 175     


Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln 
            180                 185                 190         


Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu 
        195                 200                 205             


Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro 
    210                 215                 220                 


Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg 
225                 230                 235                 240 


Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu 
                245                 250                 255     


Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn 
            260                 265                 270         


Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met 
        275                 280                 285             


Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln 
    290                 295                 300                 


Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu 
305                 310                 315                 320 


Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val 
                325                 330                 335     


Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys 
            340                 345                 350         


Gly Phe 
        


<210> 166
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"

<400> 166
Ala Ala Pro Phe 
1               


<210> 167
<211> 3
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"

<400> 167
Gly Gly Phe 
1           


<210> 168
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"

<400> 168
Ala Ala Pro Val 
1               


<210> 169
<211> 3
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"

<400> 169
Gly Gly Leu 
1           


<210> 170
<211> 3
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"

<400> 170
Ala Ala Leu 
1           


<210> 171
<211> 3
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"

<400> 171
Phe Val Arg 
1           


<210> 172
<211> 3
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"

<400> 172
Val Gly Arg 
1           


<210> 173
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"

<400> 173
Arg Gln Pro Arg 
1               


<210> 174
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 174
Tyr Val Ala Asp Xaa 
1               5   


<210> 175
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 175
Asp Xaa Xaa Asp Xaa 
1               5   


<210> 176
<211> 9
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (2)..(7)
<223> Any amino acid

<220>
<221> SITE
<222> (2)..(7)
<223> /note="This region may encompass 0, 2, 4 or 6 residues"

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<400> 176
Arg Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa 
1               5                   


<210> 177
<211> 9
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (2)..(7)
<223> Any amino acid

<220>
<221> SITE
<222> (2)..(7)
<223> /note="This region may encompass 0, 2, 4 or 6 residues"

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<400> 177
Lys Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa 
1               5                   


<210> 178
<211> 6
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<400> 178
Glu Arg Thr Lys Arg Xaa 
1               5       


<210> 179
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 179
Arg Val Arg Arg Xaa 
1               5   


<210> 180
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 180
Arg Val Arg Arg Xaa 
1               5   


<210> 181
<211> 6
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<400> 181
Pro Xaa Trp Val Pro Xaa 
1               5       


<210> 182
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 182
Trp Val Ala Xaa 
1               


<210> 183
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<400> 183
Xaa Phe Xaa Xaa 
1               


<210> 184
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<400> 184
Xaa Tyr Xaa Xaa 
1               


<210> 185
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<400> 185
Xaa Trp Xaa Xaa 
1               


<210> 186
<211> 12
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Peptidase cleavage sequence"


<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="Ala" or "Pro"

<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="Pro" or "Ala"

<220>
<221> SITE
<222> (1)..(12)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 186
Asp Arg Tyr Ile Pro Phe His Leu Leu Val Tyr Ser 
1               5                   10          


<210> 187
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 187
Ser Gly Gly Gly Gly Ser Gly Lys Ala Gly Ser Arg Gly Leu Thr 
1               5                   10                  15  


<210> 188
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 188
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Leu Arg Gln Pro Arg 
1               5                   10                  15  


<210> 189
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 189
Ser Gly Gly Gly Gly Ser Gly Lys Lys Val Glu Arg Phe Arg Tyr 
1               5                   10                  15  


<210> 190
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 190
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Leu Met Thr Pro Arg 
1               5                   10                  15  


<210> 191
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 191
Ser Gly Gly Gly Gly Ser Gly Lys Ala Gly Ser Phe Ser Glu Gly 
1               5                   10                  15  


<210> 192
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 192
Ser Gly Gly Gly Gly Ser Gly Lys Ala Gly Ser Ala Ala Pro Phe 
1               5                   10                  15  


<210> 193
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 193
Gly Gly Gly Gly Ser Gly Gly Gly Glu Asn Leu Tyr Phe Gln Ser 
1               5                   10                  15  


<210> 194
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 194
Val Ser Trp Lys Thr Trp Phe Pro Asn Leu Ala Val 
1               5                   10          


<210> 195
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 195
Tyr Ser Pro Phe His Lys Trp Phe Pro Ser Met His 
1               5                   10          


<210> 196
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 196
Ile Pro Gln Val Trp Arg Asp Trp Phe Lys Leu Pro 
1               5                   10          


<210> 197
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 197
Phe Pro Ala Trp Phe Thr Lys Leu Tyr Pro Arg Thr 
1               5                   10          


<210> 198
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 198
Gln Ile Asn Thr Ala Lys Trp Trp Lys Thr His Phe 
1               5                   10          


<210> 199
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 199
Asp Ala Ser Lys Ala Leu Arg Ser Ser Gly Met Pro 
1               5                   10          


<210> 200
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 200
Trp Lys Thr Trp Phe Pro 
1               5       


<210> 201
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 201
Ser Gly Gly Gly Gly Trp Lys Thr Trp Phe Pro Arg Gly Leu Thr 
1               5                   10                  15  


<210> 202
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 202
Ser Gly Gly Gly Gly Trp Lys Thr Trp Phe Pro Arg Gln Pro Arg 
1               5                   10                  15  


<210> 203
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 203
Ser Gly Gly Gly Gly Trp Lys Thr Trp Phe Pro Arg Phe Arg Tyr 
1               5                   10                  15  


<210> 204
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 204
Ser Gly Gly Gly Gly Trp Lys Thr Trp Phe Pro Met Thr Pro Arg 
1               5                   10                  15  


<210> 205
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 205
Ser Gly Gly Gly Gly Trp Lys Thr Trp Phe Pro Phe Ser Glu Gly 
1               5                   10                  15  


<210> 206
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 206
Ser Gly Gly Gly Gly Trp Lys Thr Trp Phe Pro Ala Ala Pro Phe 
1               5                   10                  15  


<210> 207
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 207
Gly Thr Gly Gly Ser 
1               5   


<210> 208
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 208
Gly Gly Gly Gly Ser 
1               5   


<210> 209
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 209
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 210
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 210
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 211
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 211
Gly Gly Gly Gly Ser Gly Gly Gly 
1               5               


<210> 212
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (1)..(50)
<223> /note="This sequence may encompass 1-10 'Gly Gly Gly Gly Ser'
      repeating units"

<400> 212
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210> 213
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(20)
<223> /note="This sequence may encompass 1-10 'Gly Ser'
      repeating units"

<400> 213
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210> 214
<211> 191
<212> PRT
<213> Homo sapiens

<400> 214
Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190     


<210> 215
<211> 87
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      GPL-1 agonist peptide"

<400> 215
Met Lys Ile Ile Leu Trp Leu Cys Val Phe Gly Leu Phe Leu Ala Thr 
1               5                   10                  15      


Leu Phe Pro Ile Ser Trp Gln Met Pro Val Glu Ser Gly Leu Ser Ser 
            20                  25                  30          


Glu Asp Ser Ala Ser Ser Glu Ser Phe Ala Ser Lys Ile Lys Arg His 
        35                  40                  45              


Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu Glu 
    50                  55                  60                  


Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Ser 
65                  70                  75                  80  


Gly Ala Pro Pro Pro Ser Gly 
                85          


<210> 216
<211> 110
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Insulin peptide"

<400> 216
Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210> 217
<211> 178
<212> PRT
<213> Homo sapiens

<400> 217
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 218
<211> 179
<212> PRT
<213> Homo sapiens

<400> 218
Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210> 219
<211> 71
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      ExtB polypeptide"

<400> 219
Met Lys Lys Asn Ile Ala Phe Leu Leu Ala Ser Met Phe Val Phe Ser 
1               5                   10                  15      


Ile Ala Thr Asn Ala Tyr Ala Ser Thr Gln Ser Asn Lys Lys Asp Leu 
            20                  25                  30          


Cys Glu His Tyr Arg Gln Ile Ala Lys Glu Ser Cys Lys Lys Gly Phe 
        35                  40                  45              


Leu Gly Val Arg Asp Gly Thr Ala Gly Ala Cys Phe Gly Ala Gln Ile 
    50                  55                  60                  


Met Val Ala Ala Lys Gly Cys 
65                  70      


<210> 220
<211> 225
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Red Fluorescent Protein (RFP) sequence"

<400> 220
Met Arg Ser Ser Lys Asn Val Ile Lys Glu Phe Met Arg Phe Lys Val 
1               5                   10                  15      


Arg Met Glu Gly Thr Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 
            20                  25                  30          


Gly Glu Gly Arg Pro Tyr Glu Gly His Asn Thr Val Lys Leu Lys Val 
        35                  40                  45              


Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 
    50                  55                  60                  


Phe Gln Tyr Gly Ser Lys Val Tyr Val Lys His Pro Ala Asp Ile Pro 
65                  70                  75                  80  


Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val 
                85                  90                  95      


Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser 
            100                 105                 110         


Leu Gln Asp Gly Cys Phe Ile Tyr Lys Val Lys Phe Ile Gly Val Asn 
        115                 120                 125             


Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu 
    130                 135                 140                 


Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu 
145                 150                 155                 160 


Ile His Lys Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val Glu 
                165                 170                 175     


Phe Lys Ser Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr 
            180                 185                 190         


Tyr Tyr Val Asp Ser Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr 
        195                 200                 205             


Thr Ile Val Glu Gln Tyr Glu Arg Thr Glu Gly Arg His His Leu Phe 
    210                 215                 220                 


Leu 
225 


<210> 221
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 221
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280     


