                         SEQUENCE LISTING

<110>  Valitor, Inc.
       Jackson, Wesley M.
       Mohamed, Mavish
       Brier, Livia W.
       Healy, Kevin E.
 
<120>  MULTIVALENT PEPTIDE CONJUGATES FOR SUSTAINED

<130>  052566-504001WO

<150>  62/640,749
<151>  2018-03-09

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Anti-TNFa Single-Domain Heavy-chain (VHH) Antibody

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp His 
            20                  25                  30          


Ser Gly Tyr Thr Tyr Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Glu Arg Glu Phe Val Ala Arg Ile Tyr Trp Ser Ser Gly Asn Thr Tyr 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Ile Ala 
65                  70                  75                  80  


Lys Asn Thr Val Asp Leu Thr Met Asn Asn Leu Glu Pro Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Ala Arg Asp Gly Ile Pro Thr Ser Arg Ser 
            100                 105                 110         


Val Glu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  2
<211>  149
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Anti-TNFa Single-Domain Heavy-chain (VHH) Antibody

<400>  2

Ser Asn Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            20                  25                  30          


Ser Asp His Ser Gly Tyr Thr Tyr Thr Ile Gly Trp Phe Arg Gln Ala 
        35                  40                  45              


Pro Gly Lys Glu Arg Glu Phe Val Ala Arg Ile Tyr Trp Ser Ser Gly 
    50                  55                  60                  


Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg 
65                  70                  75                  80  


Asp Ile Ala Lys Asn Thr Val Asp Leu Thr Met Asn Asn Leu Glu Pro 
                85                  90                  95      


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Asp Gly Ile Pro Thr 
            100                 105                 110         


Ser Arg Ser Val Glu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr 
    130                 135                 140                 


Pro Pro Gly Gly Cys 
145                 


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Asp His Ser Gly Tyr Thr Tyr Thr Ile Gly 
1               5                   10  


<210>  4
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ala Arg Ile Tyr Trp Ser Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  5
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Arg Asp Gly Ile Pro Thr 
1               5       


<210>  6
<211>  65
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Anti-TNFa Affibody

<400>  6

Ser Asn Ala Cys Gly Gly Gly Val Asp Asn Lys Phe Asn Lys Glu Val 
1               5                   10                  15      


Gly Trp Ala Phe Gly Glu Ile Gly Ala Leu Pro Asn Leu Asn Ala Leu 
            20                  25                  30          


Gln Phe Arg Ala Phe Ile Ile Ser Leu Trp Asp Asp Pro Ser Gln Ser 
        35                  40                  45              


Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro 
    50                  55                  60                  


Lys 
65  


<210>  7
<211>  168
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Anti-TNFa Single-Domain Heavy-chain (VHH) Antibody

<400>  7

Ser Asn Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            20                  25                  30          


Ser Asp His Ser Gly Tyr Thr Tyr Thr Ile Gly Trp Phe Arg Gln Ala 
        35                  40                  45              


Pro Gly Lys Glu Arg Glu Phe Val Ala Arg Ile Tyr Trp Ser Ser Gly 
    50                  55                  60                  


Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg 
65                  70                  75                  80  


Asp Ile Ala Lys Asn Thr Val Asp Leu Thr Met Asn Asn Leu Glu Pro 
                85                  90                  95      


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Asp Gly Ile Pro Thr 
            100                 105                 110         


Ser Arg Ser Val Glu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr 
    130                 135                 140                 


Pro Pro Gly Gly Cys Asp Asp Asp Asp Lys His His His His His His 
145                 150                 155                 160 


Asp Tyr Lys Asp Asp Asp Asp Lys 
                165             


<210>  8
<211>  169
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Anti-TNFa designed ankyrin repeat protein (DARPin)

<400>  8

Ser Asn Ala Asp Leu Gly Lys Lys Leu Leu Glu Val Ala Arg Ala Gly 
1               5                   10                  15      


Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala Ala Asp His Gln Ser Phe Thr Pro Leu His Leu Tyr Ala Ile Phe 
        35                  40                  45              


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
    50                  55                  60                  


Asn Ala Ser Asp Trp His Gly Asn Thr Pro Leu His Leu Ala Ala Trp 
65                  70                  75                  80  


Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
                85                  90                  95      


Val Asn Ala Thr Asp His Ser Gly Ser Thr Pro Leu His Leu Ala Ala 
            100                 105                 110         


Thr Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala 
        115                 120                 125             


Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
    130                 135                 140                 


Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Ser Cys 
                165                 


<210>  9
<211>  268
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Anti-IL-1B Single-Chain (scFv) Antibody

<400>  9

Ser Asn Ala Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Ser Ile 
            20                  25                  30          


Asp Asn Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly 
                85                  90                  95      


Gly Val Ser Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Ser Ser Ala Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Gly Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Glu Arg Ala Ile Phe Ser Gly Asp Phe Val Leu 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Gly Gly Cys 
            260                 265             


<210>  10
<211>  340
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Soluble interleukin receptor 2 (sILR2)

<400>  10

His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly Arg His Tyr Lys 
1               5                   10                  15      


Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu Arg Cys Pro Gln 
            20                  25                  30          


Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg Ile Asn Leu Thr 
        35                  40                  45              


Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly Glu Glu Glu Thr 
    50                  55                  60                  


Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu Pro Ala Leu Gln 
65                  70                  75                  80  


Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn Ala Ser Tyr Cys 
                85                  90                  95      


Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn Thr Asp Ala Phe 
            100                 105                 110         


Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu Ser Thr Ser Gly 
        115                 120                 125             


Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg Asp Lys Thr Asp 
    130                 135                 140                 


Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu Asp Lys Asp Asn 
145                 150                 155                 160 


Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu Leu Val His Asp 
                165                 170                 175     


Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val Leu Thr Phe Ala 
            180                 185                 190         


His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile Glu Leu Arg Ile 
        195                 200                 205             


Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile Ser Pro Leu Lys 
    210                 215                 220                 


Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile Pro Cys Lys Val 
225                 230                 235                 240 


Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu Trp Trp Thr Ala 
                245                 250                 255     


Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly Arg Val Thr Glu 
            260                 265                 270         


Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn Tyr Ile Glu Val 
        275                 280                 285             


Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu His Met Asp Phe 
    290                 295                 300                 


Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr Leu Arg Thr Thr 
305                 310                 315                 320 


Val Lys Glu Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro 
                325                 330                 335     


Pro Gly Gly Cys 
            340 


<210>  11
<211>  155
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Anti-(mouse)TNFa Single-Domain Heavy-chain (VHH) Antibody

<400>  11

Ser Asn Ala Gln Val Gln Leu Gln Asp Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe 
            20                  25                  30          


Ser Ser Ile Ile Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Gly Ala Val Ser Trp Ser Gly Gly Thr Thr Val Tyr Ala 
    50                  55                  60                  


Asp Ser Val Leu Gly Arg Phe Glu Ile Ser Arg Asp Ser Ala Arg Lys 
65                  70                  75                  80  


Ser Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Arg Pro Tyr Gln Lys Tyr Asn Trp Ala Ser Ala 
            100                 105                 110         


Ser Tyr Asn Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser 
        115                 120                 125             


Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Gly Gly Cys 
    130                 135                 140                 


Asp Asp Asp Asp Lys His His His His His His 
145                 150                 155 


