                         SEQUENCE LISTING

<110>  AvroBio, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING PARKINSON'S DISEASE

<130>  51182-007WO2

<150>  US 62/641,012
<151>  2018-03-09

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  2
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln Gly Gly Gly Gly Ala Gly Gly Gly 
    530                 535                 540                 


Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Pro 
545                 550                 555                 560 


Ser Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly 
                565                 570                 575     


Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Ala Arg 
            580                 585                 590         


Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala 
        595                 600                 605             


Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu 
    610                 615                 620     


<210>  3
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln Gly Ala Pro Gly Gly Gly Ser Pro 
    530                 535                 540                 


Ala Pro Ala Pro Thr Pro Ala Pro Ala Pro Thr Pro Ala Pro Ala Gly 
545                 550                 555                 560 


Gly Gly Pro Ser Gly Ala Pro Leu Cys Gly Gly Glu Leu Val Asp Thr 
                565                 570                 575     


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            580                 585                 590         


Ser Arg Val Ser Ala Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        595                 600                 605             


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    610                 615                 620                 


Lys Ser Glu 
625         


<210>  4
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln Gly Ala Pro Gly Gly Ser Pro Ala 
    530                 535                 540                 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
545                 550                 555                 560 


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                565                 570                 575     


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Gly Pro Ser Gly Ala Pro 
            580                 585                 590         


Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp 
        595                 600                 605             


Arg Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Ala Arg Ser 
    610                 615                 620                 


Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu 
625                 630                 635                 640 


Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu 
                645                 650         


<210>  5
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Arg Pro Cys Ile Pro Lys Ser 
            20                  25                  30          


Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp 
        35                  40                  45              


Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr 
    50                  55                  60                  


Glu Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile 
65                  70                  75                  80  


Gln Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu 
                85                  90                  95      


Gln Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala 
            100                 105                 110         


Ala Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu 
        115                 120                 125             


Leu Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg 
    130                 135                 140                 


Val Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala 
145                 150                 155                 160 


Asp Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu 
                165                 170                 175     


Asp Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala 
            180                 185                 190         


Gln Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp 
        195                 200                 205             


Leu Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln 
    210                 215                 220                 


Pro Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe 
225                 230                 235                 240 


Leu Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala 
                245                 250                 255     


Glu Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys 
            260                 265                 270         


Leu Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu 
        275                 280                 285             


Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met 
    290                 295                 300                 


Leu Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu 
305                 310                 315                 320 


Thr Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp 
                325                 330                 335     


Tyr Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His 
            340                 345                 350         


Arg Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly 
        355                 360                 365             


Ser Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly 
    370                 375                 380                 


Met Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val 
385                 390                 395                 400 


Gly Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn 
                405                 410                 415     


Trp Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys 
            420                 425                 430         


Asp Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser 
        435                 440                 445             


Lys Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln 
    450                 455                 460                 


Lys Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala 
465                 470                 475                 480 


Val Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile 
                485                 490                 495     


Lys Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser 
            500                 505                 510         


Ile His Thr Tyr Leu Trp Arg Arg Gln 
        515                 520     


<210>  6
<211>  2275
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2005)..(2005)
<223>  n is a, c, g, or t

<400>  6
gctaacctag tgcctatagc taaggcaggt acctgcatcc ttgtttttgt ttagtggatc       60

ctctatcctt cagagactct ggaacccctg tggtcttctc ttcatctaat gaccctgagg      120

ggatggagtt ttcaagtcct tccagagagg aatgtcccaa gcctttgagt agggtaagca      180

tcatggctgg cagcctcaca ggtttgcttc tacttcaggc agtgtcgtgg gcatcaggtg      240

cccgcccctg catccctaaa agcttcggct acagctcggt ggtgtgtgtc tgcaatgcca      300

catactgtga ctcctttgac cccccgacct ttcctgccct tggtaccttc agccgctatg      360

agagtacacg cagtgggcga cggatggagc tgagtatggg gcccatccag gctaatcaca      420

cgggcacagg cctgctactg accctgcagc cagaacagaa gttccagaaa gtgaagggat      480

ttggaggggc catgacagat gctgctgctc tcaacatcct tgccctgtca ccccctgccc      540

aaaatttgct acttaaatcg tacttctctg aagaaggaat cggatataac atcatccggg      600

tacccatggc cagctgtgac ttctccatcc gcacctacac ctatgcagac acccctgatg      660

atttccagtt gcacaacttc agcctcccag aggaagatac caagctcaag atacccctga      720

ttcaccgagc cctgcagttg gcccagcgtc ccgtttcact ccttgccagc ccctggacat      780

cacccacttg gctcaagacc aatggagcgg tgaatgggaa ggggtcactc aagggacagc      840

ccggagacat ctaccaccag acctgggcca gatactttgt gaagttcctg gatgcctatg      900

ctgagcacaa gttacagttc tgggcagtga cagctgaaaa tgagccttct gctgggctgt      960

tgagtggata ccccttccag tgcctgggct tcacccctga acatcagcga gacttcattg     1020

cccgtgacct aggtcctacc ctcgccaaca gtactcacca caatgtccgc ctactcatgc     1080

tggatgacca acgcttgctg ctgccccact gggcaaaggt ggtactgaca gacccagaag     1140

cagctaaata tgttcatggc attgctgtac attggtacct ggactttctg gctccagcca     1200

aagccaccct aggggagaca caccgcctgt tccccaacac catgctcttt gcctcagagg     1260

cctgtgtggg ctccaagttc tgggagcaga gtgtgcggct aggctcctgg gatcgaggga     1320

tgcagtacag ccacagcatc atcacgaacc tcctgtacca tgtggtcggc tggaccgact     1380

ggaaccttgc cctgaacccc gaaggaggac ccaattgggt gcgtaacttt gtcgacagtc     1440

ccatcattgt agacatcacc aaggacacgt tttacaaaca gcccatgttc taccaccttg     1500

gccacttcag caagttcatt cctgagggct cccagagagt ggggctggtt gccagtcaga     1560

agaacgacct ggacgcagtg gcactgatgc atcccgatgg ctctgctgtt gtggtcgtgc     1620

taaaccgctc ctctaaggat gtgcctctta ccatcaagga tcctgctgtg ggcttcctgg     1680

agacaatctc acctggctac tccattcaca cctacctgtg gcatcgccag tgatggagca     1740

gatactcaag gaggcactgg gctcagcctg ggcattaaag ggacagagtc agctcacacg     1800

ctgtctgtga ctaaagaggg cacagcaggg ccagtgtgag cttacagcga cgtaagccca     1860

ggggcaatgg tttgggtgac tcactttccc ctctaggtgg tgcccagggc tggaggcccc     1920

tagaaaaaga tcagtaagcc ccagtgtccc cccagccccc atgcttatgt gaacatgcgc     1980

tgtgtgctgc ttgctttgga aactngcctg ggtccaggcc tagggtgagc tcactgtccg     2040

tacaaacaca agatcagggc tgagggtaag gaaaagaaga gactaggaaa gctgggccca     2100

aaactggaga ctgtttgtct ttcctagaga tgcagaactg ggcccgtgga gcagcagtgt     2160

cagcatcagg gcggaagcct taaagcagca gcgggtgtgc ccaggcaccc agatgattcc     2220

tatggcacca gccaggaaaa atggcagctc ttaaaggaga aaatgtttga gccca          2275


<210>  7
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
atggaattca gcagccccag ccgggaggaa tgccccaagc ccctgagcag agtgtccatc       60

atggccggat ctctgaccgg actgctgctg ctgcaagccg tgtcttgggc cagcggcgcc      120

agaccttgca tccccaagag cttcggctac agcagcgtcg tgtgcgtgtg caacgccacc      180

tactgcgaca gcttcgaccc ccctaccttt cccgccctgg gcaccttcag cagatacgag      240

agcacccgca gcggcagacg gatggaactg agcatgggcc ccatccaggc caatcacacc      300

ggaaccggcc tgctgctgac cctgcagccc gagcagaaat tccagaaagt gaagggcttc      360

ggcggagcca tgacagacgc cgctgccctg aacatcctgg ccctgagccc ccctgctcag      420

aatctgctgc tcaagagcta cttcagcgag gaaggcatcg gctacaacat catccgggtg      480

cccatggcta gctgcgactt cagcatccgg acctacacct acgccgacac ccccgacgac      540

ttccagctgc acaacttcag cctgcccgaa gaggacacca agctgaagat ccccctgatc      600

cacagagccc tgcagctggc ccagaggcct gtgtctctgc tggctagccc ttggaccagc      660

cccacctggc tgaaaaccaa cggagccgtg aacggcaagg gcagcctgaa gggccagccc      720

ggcgacatct accaccagac ctgggcccgg tacttcgtga agttcctgga cgcctatgcc      780

gagcacaagc tgcagttctg ggccgtgacc gccgagaatg agcctagcgc tggactgctg      840

tccggctacc ccttccaatg cctgggcttc acacccgagc accagcggga ctttatcgcc      900

agagatctgg gccccacact ggccaacagc acccaccaca acgtgcggct gctgatgctg      960

gacgaccaga gactgctgct cccccactgg gccaaggtgg tgctgacaga ccccgaggcc     1020

gccaaatacg tccacgggat tgccgtgcac tggtatctgg actttctggc ccctgccaag     1080

gccacactgg gcgagacaca ccggctgttc cccaacacca tgctgttcgc cagcgaggcc     1140

tgcgtgggca gcaagttctg ggagcagagc gtgcggctgg gcagctggga cagaggcatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccacg tcgtgggctg gaccgactgg     1260

aatctggccc tgaaccctga gggaggaccc aactgggtcc gcaacttcgt ggacagcccc     1320

atcatcgtgg acatcaccaa ggacaccttc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc cgagggcagc cagagagtgg gactggtcgc cagccagaag     1440

aacgatctgg acgccgtggc cctgatgcac cctgatggca gcgctgtggt ggtggtcctg     1500

aatcggtcca gcaaggacgt gcccctgacc atcaaggacc ccgccgtggg cttcctggaa     1560

accatcagcc ccggctactc catccacacc tacctgtggc ggagacaatg a              1611


<210>  8
<211>  1869
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
atggaattca gcagccccag ccgggaggaa tgccccaagc ccctgagcag agtgtccatc       60

atggccggat ctctgaccgg actgctgctg ctgcaagccg tgtcttgggc cagcggcgcc      120

agaccttgca tccccaagag cttcggctac agcagcgtcg tgtgcgtgtg caacgccacc      180

tactgcgaca gcttcgaccc ccctaccttt cccgccctgg gcaccttcag cagatacgag      240

agcacccgca gcggcagacg gatggaactg agcatgggcc ccatccaggc caatcacacc      300

ggaaccggcc tgctgctgac cctgcagccc gagcagaaat tccagaaagt gaagggcttc      360

ggcggagcca tgacagacgc cgctgccctg aacatcctgg ccctgagccc ccctgctcag      420

aatctgctgc tcaagagcta cttcagcgag gaaggcatcg gctacaacat catccgggtg      480

cccatggcta gctgcgactt cagcatccgg acctacacct acgccgacac ccccgacgac      540

ttccagctgc acaacttcag cctgcccgaa gaggacacca agctgaagat ccccctgatc      600

cacagagccc tgcagctggc ccagaggcct gtgtctctgc tggctagccc ttggaccagc      660

cccacctggc tgaaaaccaa cggagccgtg aacggcaagg gcagcctgaa gggccagccc      720

ggcgacatct accaccagac ctgggcccgg tacttcgtga agttcctgga cgcctatgcc      780

gagcacaagc tgcagttctg ggccgtgacc gccgagaatg agcctagcgc tggactgctg      840

tccggctacc ccttccaatg cctgggcttc acacccgagc accagcggga ctttatcgcc      900

agagatctgg gccccacact ggccaacagc acccaccaca acgtgcggct gctgatgctg      960

gacgaccaga gactgctgct cccccactgg gccaaggtgg tgctgacaga ccccgaggcc     1020

gccaaatacg tccacgggat tgccgtgcac tggtatctgg actttctggc ccctgccaag     1080

gccacactgg gcgagacaca ccggctgttc cccaacacca tgctgttcgc cagcgaggcc     1140

tgcgtgggca gcaagttctg ggagcagagc gtgcggctgg gcagctggga cagaggcatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccacg tcgtgggctg gaccgactgg     1260

aatctggccc tgaaccctga gggaggaccc aactgggtcc gcaacttcgt ggacagcccc     1320

atcatcgtgg acatcaccaa ggacaccttc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc cgagggcagc cagagagtgg gactggtcgc cagccagaag     1440

aacgatctgg acgccgtggc cctgatgcac cctgatggca gcgctgtggt ggtggtcctg     1500

aatcggtcca gcaaggacgt gcccctgacc atcaaggacc ccgccgtggg cttcctggaa     1560

accatcagcc ccggctactc catccacacc tacctgtggc ggagacaagg cggaggcgga     1620

gctggtggcg gcggagcagg cggtggtggt gcaggcggcg gaggtgctgg cggaggacca     1680

tctctttgtg gcggagaact ggtggacacc ctgcagttcg tgtgtggcga cagaggcttc     1740

tactttagca gacccgccag cagagtgtcc gccagatcta gaggaatcgt ggaagagtgc     1800

tgcttcagaa gctgcgacct ggcactgctg gaaacctact gtgccacacc agccaagagc     1860

gagtgatga                                                             1869


<210>  9
<211>  1887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
atggaattca gcagccccag ccgggaggaa tgccccaagc ccctgagcag agtgtccatc       60

atggccggat ctctgaccgg actgctgctg ctgcaagccg tgtcttgggc cagcggcgcc      120

agaccttgca tccccaagag cttcggctac agcagcgtcg tgtgcgtgtg caacgccacc      180

tactgcgaca gcttcgaccc ccctaccttt cccgccctgg gcaccttcag cagatacgag      240

agcacccgca gcggcagacg gatggaactg agcatgggcc ccatccaggc caatcacacc      300

ggaaccggcc tgctgctgac cctgcagccc gagcagaaat tccagaaagt gaagggcttc      360

ggcggagcca tgacagacgc cgctgccctg aacatcctgg ccctgagccc ccctgctcag      420

aatctgctgc tcaagagcta cttcagcgag gaaggcatcg gctacaacat catccgggtg      480

cccatggcta gctgcgactt cagcatccgg acctacacct acgccgacac ccccgacgac      540

ttccagctgc acaacttcag cctgcccgaa gaggacacca agctgaagat ccccctgatc      600

cacagagccc tgcagctggc ccagaggcct gtgtctctgc tggctagccc ttggaccagc      660

cccacctggc tgaaaaccaa cggagccgtg aacggcaagg gcagcctgaa gggccagccc      720

ggcgacatct accaccagac ctgggcccgg tacttcgtga agttcctgga cgcctatgcc      780

gagcacaagc tgcagttctg ggccgtgacc gccgagaatg agcctagcgc tggactgctg      840

tccggctacc ccttccaatg cctgggcttc acacccgagc accagcggga ctttatcgcc      900

agagatctgg gccccacact ggccaacagc acccaccaca acgtgcggct gctgatgctg      960

gacgaccaga gactgctgct cccccactgg gccaaggtgg tgctgacaga ccccgaggcc     1020

gccaaatacg tccacgggat tgccgtgcac tggtatctgg actttctggc ccctgccaag     1080

gccacactgg gcgagacaca ccggctgttc cccaacacca tgctgttcgc cagcgaggcc     1140

tgcgtgggca gcaagttctg ggagcagagc gtgcggctgg gcagctggga cagaggcatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccacg tcgtgggctg gaccgactgg     1260

aatctggccc tgaaccctga gggaggaccc aactgggtcc gcaacttcgt ggacagcccc     1320

atcatcgtgg acatcaccaa ggacaccttc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc cgagggcagc cagagagtgg gactggtcgc cagccagaag     1440

aacgatctgg acgccgtggc cctgatgcac cctgatggca gcgctgtggt ggtggtcctg     1500

aatcggtcca gcaaggacgt gcccctgacc atcaaggacc ccgccgtggg cttcctggaa     1560

accatcagcc ccggctactc catccacacc tacctgtggc ggagacaagg agcaccaggc     1620

ggaggatctc cagctcctgc tcctacacca gctccagcac cgacgcctgc tccagctggc     1680

ggaggacctt ctggtgcacc tctttgtggc ggagagctgg tggataccct gcagttcgtg     1740

tgtggcgacc ggggcttcta ctttagcaga cctgccagca gagtgtccgc cagatctaga     1800

ggcatcgtgg aagagtgctg cttcagaagc tgcgacctgg cactgctgga aacctactgt     1860

gccacaccag ccaagagcga gtgatga                                         1887


<210>  10
<211>  1962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
atggaattca gcagccccag ccgggaggaa tgccccaagc ccctgagcag agtgtccatc       60

atggccggat ctctgaccgg actgctgctg ctgcaagccg tgtcttgggc cagcggcgcc      120

agaccttgca tccccaagag cttcggctac agcagcgtcg tgtgcgtgtg caacgccacc      180

tactgcgaca gcttcgaccc ccctaccttt cccgccctgg gcaccttcag cagatacgag      240

agcacccgca gcggcagacg gatggaactg agcatgggcc ccatccaggc caatcacacc      300

ggaaccggcc tgctgctgac cctgcagccc gagcagaaat tccagaaagt gaagggcttc      360

ggcggagcca tgacagacgc cgctgccctg aacatcctgg ccctgagccc ccctgctcag      420

aatctgctgc tcaagagcta cttcagcgag gaaggcatcg gctacaacat catccgggtg      480

cccatggcta gctgcgactt cagcatccgg acctacacct acgccgacac ccccgacgac      540

ttccagctgc acaacttcag cctgcccgaa gaggacacca agctgaagat ccccctgatc      600

cacagagccc tgcagctggc ccagaggcct gtgtctctgc tggctagccc ttggaccagc      660

cccacctggc tgaaaaccaa cggagccgtg aacggcaagg gcagcctgaa gggccagccc      720

ggcgacatct accaccagac ctgggcccgg tacttcgtga agttcctgga cgcctatgcc      780

gagcacaagc tgcagttctg ggccgtgacc gccgagaatg agcctagcgc tggactgctg      840

tccggctacc ccttccaatg cctgggcttc acacccgagc accagcggga ctttatcgcc      900

agagatctgg gccccacact ggccaacagc acccaccaca acgtgcggct gctgatgctg      960

gacgaccaga gactgctgct cccccactgg gccaaggtgg tgctgacaga ccccgaggcc     1020

gccaaatacg tccacgggat tgccgtgcac tggtatctgg actttctggc ccctgccaag     1080

gccacactgg gcgagacaca ccggctgttc cccaacacca tgctgttcgc cagcgaggcc     1140

tgcgtgggca gcaagttctg ggagcagagc gtgcggctgg gcagctggga cagaggcatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccacg tcgtgggctg gaccgactgg     1260

aatctggccc tgaaccctga gggaggaccc aactgggtcc gcaacttcgt ggacagcccc     1320

atcatcgtgg acatcaccaa ggacaccttc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc cgagggcagc cagagagtgg gactggtcgc cagccagaag     1440

aacgatctgg acgccgtggc cctgatgcac cctgatggca gcgctgtggt ggtggtcctg     1500

aatcggtcca gcaaggacgt gcccctgacc atcaaggacc ccgccgtggg cttcctggaa     1560

accatcagcc ccggctactc catccacacc tacctgtggc ggagacaagg agcaccaggc     1620

ggatctccag caggatctcc aacctctacc gaggaaggca caagcgagtc tgccacacct     1680

gagtctggac ctggcacaag cacagagcct agcgaaggat ctgccccagg ttctcctgcc     1740

ggctctccta caagtacagg accttctggc gctccactgt gtggcggaga actggtggat     1800

accctgcagt tcgtgtgcgg cgacagaggc ttctacttta gcagacccgc cagcagagtg     1860

tccgccagat ctagaggaat cgtggaagag tgctgcttca gaagctgcga tctggcactg     1920

ctggaaacct actgtgccac accagccaag agcgagtgat ga                        1962


<210>  11
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
atggggattc ctatgggcaa gtctatgctg gtcctgctga catttctggc cttcgcttca       60

tgctgtatcg ctgccagacc ttgcatcccc aagagcttcg gctacagcag cgtcgtgtgc      120

gtgtgcaacg ccacctactg cgacagcttc gaccccccta cctttcccgc cctgggcacc      180

ttcagcagat acgagagcac ccgcagcggc agacggatgg aactgagcat gggccccatc      240

caggccaatc acaccggaac cggcctgctg ctgaccctgc agcccgagca gaaattccag      300

aaagtgaagg gcttcggcgg agccatgaca gacgccgctg ccctgaacat cctggccctg      360

agcccccctg ctcagaatct gctgctcaag agctacttca gcgaggaagg catcggctac      420

aacatcatcc gggtgcccat ggctagctgc gacttcagca tccggaccta cacctacgcc      480

gacacccccg acgacttcca gctgcacaac ttcagcctgc ccgaagagga caccaagctg      540

aagatccccc tgatccacag agccctgcag ctggcccaga ggcctgtgtc tctgctggct      600

agcccttgga ccagccccac ctggctgaaa accaacggag ccgtgaacgg caagggcagc      660

ctgaagggcc agcccggcga catctaccac cagacctggg cccggtactt cgtgaagttc      720

ctggacgcct atgccgagca caagctgcag ttctgggccg tgaccgccga gaatgagcct      780

agcgctggac tgctgtccgg ctaccccttc caatgcctgg gcttcacacc cgagcaccag      840

cgggacttta tcgccagaga tctgggcccc acactggcca acagcaccca ccacaacgtg      900

cggctgctga tgctggacga ccagagactg ctgctccccc actgggccaa ggtggtgctg      960

acagaccccg aggccgccaa atacgtccac gggattgccg tgcactggta tctggacttt     1020

ctggcccctg ccaaggccac actgggcgag acacaccggc tgttccccaa caccatgctg     1080

ttcgccagcg aggcctgcgt gggcagcaag ttctgggagc agagcgtgcg gctgggcagc     1140

tgggacagag gcatgcagta cagccacagc atcatcacca acctgctgta ccacgtcgtg     1200

ggctggaccg actggaatct ggccctgaac cctgagggag gacccaactg ggtccgcaac     1260

ttcgtggaca gccccatcat cgtggacatc accaaggaca ccttctacaa gcagcccatg     1320

ttctaccacc tgggccactt cagcaagttc atccccgagg gcagccagag agtgggactg     1380

gtcgccagcc agaagaacga tctggacgcc gtggccctga tgcaccctga tggcagcgct     1440

gtggtggtgg tcctgaatcg gtccagcaag gacgtgcccc tgaccatcaa ggaccccgcc     1500

gtgggcttcc tggaaaccat cagccccggc tactccatcc acacctacct gtggcggaga     1560

caatga                                                                1566


<210>  12
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  13
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ala Gly Gly Gly Pro Ser Leu Cys Gly Gly Glu Leu Val 
            20                  25                  30          


Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg 
        35                  40                  45              


Pro Ala Ser Arg Val Ser Ala Arg Ser Arg Gly Ile Val Glu Glu Cys 
    50                  55                  60                  


Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr 
65                  70                  75                  80  


Pro Ala Lys Ser Glu 
                85  


<210>  14
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gly Ala Pro Gly Gly Gly Ser Pro Ala Pro Ala Pro Thr Pro Ala Pro 
1               5                   10                  15      


Ala Pro Thr Pro Ala Pro Ala Gly Gly Gly Pro Ser Gly Ala Pro Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Ala Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu 
                85                  90      


<210>  15
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Gly Ala Pro Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
1               5                   10                  15      


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
            20                  25                  30          


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
        35                  40                  45              


Ser Thr Gly Pro Ser Gly Ala Pro Leu Cys Gly Gly Glu Leu Val Asp 
    50                  55                  60                  


Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro 
65                  70                  75                  80  


Ala Ser Arg Val Ser Ala Arg Ser Arg Gly Ile Val Glu Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro 
            100                 105                 110         


Ala Lys Ser Glu 
        115     


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala 
            20                  


<210>  17
<211>  261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
ggcggaggcg gagctggtgg cggcggagca ggcggtggtg gtgcaggcgg cggaggtgct       60

ggcggaggac catctctttg tggcggagaa ctggtggaca ccctgcagtt cgtgtgtggc      120

gacagaggct tctactttag cagacccgcc agcagagtgt ccgccagatc tagaggaatc      180

gtggaagagt gctgcttcag aagctgcgac ctggcactgc tggaaaccta ctgtgccaca      240

ccagccaaga gcgagtgatg a                                                261


<210>  18
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
ggagcaccag gcggaggatc tccagctcct gctcctacac cagctccagc accgacgcct       60

gctccagctg gcggaggacc ttctggtgca cctctttgtg gcggagagct ggtggatacc      120

ctgcagttcg tgtgtggcga ccggggcttc tactttagca gacctgccag cagagtgtcc      180

gccagatcta gaggcatcgt ggaagagtgc tgcttcagaa gctgcgacct ggcactgctg      240

gaaacctact gtgccacacc agccaagagc gagtgatga                             279


<210>  19
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
ggagcaccag gcggatctcc agcaggatct ccaacctcta ccgaggaagg cacaagcgag       60

tctgccacac ctgagtctgg acctggcaca agcacagagc ctagcgaagg atctgcccca      120

ggttctcctg ccggctctcc tacaagtaca ggaccttctg gcgctccact gtgtggcgga      180

gaactggtgg ataccctgca gttcgtgtgc ggcgacagag gcttctactt tagcagaccc      240

gccagcagag tgtccgccag atctagagga atcgtggaag agtgctgctt cagaagctgc      300

gatctggcac tgctggaaac ctactgtgcc acaccagcca agagcgagtg atga            354


<210>  20
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
atggggattc ctatgggcaa gtctatgctg gtcctgctga catttctggc cttcgcttca       60

tgctgtatcg ct                                                           72


<210>  21
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


