                         SEQUENCE LISTING

<110>  EpiCypher, Inc.
       Cowles, Martis William
       Keogh, Michael-Christopher
       Burg, Jonathan M.
       Sun, Zu-Wen
 
<120>  Peptide Ligase-mediated Engineering of Recombinant Nucleosomes

<130>  1426-12WO

<150>  US 62/639,802
<151>  2018-03-07

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ala Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Lys Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His Lys Ala Lys 
        115                 120                 125             


Gly Lys 
    130 


<210>  2
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  3
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  4
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  5
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      


Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          


Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              


Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  


Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      


Thr Leu Tyr Gly Phe Gly Gly 
            100             


<210>  6
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  recognition site


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any naturally occurring amino acid

<400>  6

Leu Pro Xaa Thr Gly 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  recognition site

<400>  7

Asn Pro Gln Thr Asn 
1               5   


<210>  8
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  recognition site


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Q or K

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is T or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is N, G or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D or A

<400>  8

Asn Pro Xaa Xaa Xaa Xaa 
1               5       


<210>  9
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  recognition site

<400>  9

Leu Pro Leu Thr Gly 
1               5   


<210>  10
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  recognition site


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa is any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  Xaa is any naturally occurring amino acid

<400>  10

Trp Xaa Xaa Xaa Val Xaa Xaa Tyr Pro Lys 
1               5                   10  


<210>  11
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  recognition site

<400>  11

Leu Pro Asn Thr Ala 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  recognition site


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any naturally occurring amino acid

<400>  12

Leu Ala Xaa Thr Gly 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  recognition site


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any naturally occurring amino acid

<400>  13

Ala Pro Xaa Thr Gly 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  recognition site

<400>  14

Leu Pro Ala Thr Gly 
1               5   


