                               SEQUENCE LISTING

<110> BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
 
<120> COMPOSITIONS AND METHODS FOR TREATING CANCER

<130> 167688.011501/PCT

<140> PCT/US2019/020924
<141> 2019-03-06

<150> 62/639,561
<151> 2018-03-07

<160> 32    

<170> PatentIn version 3.5

<210> 1
<211> 424
<212> PRT
<213> Homo sapiens

<400> 1
Met His Arg Lys His Leu Gln Glu Ile Pro Asp Leu Ser Ser Asn Val 
1               5                   10                  15      


Ala Thr Ser Phe Thr Trp Gly Trp Asp Ser Ser Lys Thr Ser Glu Leu 
            20                  25                  30          


Leu Ser Gly Met Gly Val Ser Ala Leu Glu Lys Glu Glu Pro Asp Ser 
        35                  40                  45              


Glu Asn Ile Pro Gln Glu Leu Leu Ser Asn Leu Gly His Pro Glu Ser 
    50                  55                  60                  


Pro Pro Arg Lys Arg Leu Lys Ser Lys Gly Ser Asp Lys Asp Phe Val 
65                  70                  75                  80  


Ile Val Arg Arg Pro Lys Leu Asn Arg Glu Asn Phe Pro Gly Val Ser 
                85                  90                  95      


Trp Asp Ser Leu Pro Asp Glu Leu Leu Leu Gly Ile Phe Ser Cys Leu 
            100                 105                 110         


Cys Leu Pro Glu Leu Leu Lys Val Ser Gly Val Cys Lys Arg Trp Tyr 
        115                 120                 125             


Arg Leu Ala Ser Asp Glu Ser Leu Trp Gln Thr Leu Asp Leu Thr Gly 
    130                 135                 140                 


Lys Asn Leu His Pro Asp Val Thr Gly Arg Leu Leu Ser Gln Gly Val 
145                 150                 155                 160 


Ile Ala Phe Arg Cys Pro Arg Ser Phe Met Asp Gln Pro Leu Ala Glu 
                165                 170                 175     


His Phe Ser Pro Phe Arg Val Gln His Met Asp Leu Ser Asn Ser Val 
            180                 185                 190         


Ile Glu Val Ser Thr Leu His Gly Ile Leu Ser Gln Cys Ser Lys Leu 
        195                 200                 205             


Gln Asn Leu Ser Leu Glu Gly Leu Arg Leu Ser Asp Pro Ile Val Asn 
    210                 215                 220                 


Thr Leu Ala Lys Asn Ser Asn Leu Val Arg Leu Asn Leu Ser Gly Cys 
225                 230                 235                 240 


Ser Gly Phe Ser Glu Phe Ala Leu Gln Thr Leu Leu Ser Ser Cys Ser 
                245                 250                 255     


Arg Leu Asp Glu Leu Asn Leu Ser Trp Cys Phe Asp Phe Thr Glu Lys 
            260                 265                 270         


His Val Gln Val Ala Val Ala His Val Ser Glu Thr Ile Thr Gln Leu 
        275                 280                 285             


Asn Leu Ser Gly Tyr Arg Lys Asn Leu Gln Lys Ser Asp Leu Ser Thr 
    290                 295                 300                 


Leu Val Arg Arg Cys Pro Asn Leu Val His Leu Asp Leu Ser Asp Ser 
305                 310                 315                 320 


Val Met Leu Lys Asn Asp Cys Phe Gln Glu Phe Phe Gln Leu Asn Tyr 
                325                 330                 335     


Leu Gln His Leu Ser Leu Ser Arg Cys Tyr Asp Ile Ile Pro Glu Thr 
            340                 345                 350         


Leu Leu Glu Leu Gly Glu Ile Pro Thr Leu Lys Thr Leu Gln Val Phe 
        355                 360                 365             


Gly Ile Val Pro Asp Gly Thr Leu Gln Leu Leu Lys Glu Ala Leu Pro 
    370                 375                 380                 


His Leu Gln Ile Asn Cys Ser His Phe Thr Thr Ile Ala Arg Pro Thr 
385                 390                 395                 400 


Ile Gly Asn Lys Lys Asn Gln Glu Ile Trp Gly Ile Lys Cys Arg Leu 
                405                 410                 415     


Thr Leu Gln Lys Pro Ser Cys Leu 
            420                 


<210> 2
<211> 3520
<212> DNA
<213> Homo sapiens

<400> 2
aattcccagc aggccttggg cctcagtgcg gccgcgaagc agagcgggct gtagagcctt       60

gcgcgcgcag tggggatgga acgttgctag gcttagcggg tctggctgct gggggcccga      120

gcagcacgct cggagccgcc gcgcgccaaa gcgggaatct gggaggcgag cagctctgca      180

gttaatgcac gtattttaaa ctcccgggcc tgcggacgct atgcacagga agcacctcca      240

ggagattcca gacctgagta gcaacgttgc caccagcttc acgtggggat gggattccag      300

caagacttct gaactgctgt caggcatggg ggtctccgcc ctggagaaag aggagcccga      360

cagtgagaac atcccccagg aactgctctc aaacctgggc cacccggaga gccccccacg      420

gaaacggctg aagagcaaag ggagtgacaa agactttgtg attgtccgca ggcctaagct      480

aaatcgagag aactttccag gtgtttcatg ggactccctt ccggatgagc tgctcttggg      540

aatcttttcc tgtctgtgcc tccctgagct gctaaaggtc tctggtgttt gtaagaggtg      600

gtatcgccta gcgtctgatg agtctctatg gcagacctta gacctcacag gtaaaaatct      660

gcacccggat gtgactggtc ggttgctgtc tcaaggggtg attgccttcc gctgcccacg      720

atcatttatg gaccaaccat tggctgaaca tttcagccct tttcgtgtac agcacatgga      780

cctatcgaac tcagttatag aagtgtccac cctccacggc atactgtctc agtgttccaa      840

gttgcagaat ctaagcctgg aaggcctgcg gctttcggat cccattgtca atactctcgc      900

aaaaaactca aatttagtgc gacttaacct ttctgggtgt tctggattct ctgaatttgc      960

cctgcagact ttgctaagca gctgttccag actggatgag ctgaacctct cctggtgttt     1020

tgatttcact gaaaagcatg tacaggtggc tgttgcgcat gtgtcagaga ccatcaccca     1080

gctgaatctt agcggctaca gaaagaatct ccagaaatca gatctctcta ctttagttag     1140

aagatgcccc aatcttgtcc atctagactt aagtgatagt gtcatgctaa agaatgactg     1200

ctttcaggaa tttttccagc tcaactacct ccaacaccta tcactcagtc ggtgctatga     1260

tataatacct gaaactttac ttgaacttgg agaaattccc acactaaaaa cactacaagt     1320

ttttggaatc gtgccagatg gtacccttca actgttaaag gaagcccttc ctcatctaca     1380

gattaattgc tcccatttca ccaccattgc caggccaact attggcaaca aaaagaacca     1440

ggagatatgg ggcatcaaat gccgactgac actgcaaaag cccagttgtc tatgaagtat     1500

ttattgcagg atggtgtctc ttctttagaa cagggaaaat aggcaggaag cccaattgct     1560

ggagtactta gctagtttta ttcttggttt tccctttgcc ttcattctgc aagtatacta     1620

gggagccatt tgagagggaa aactatgaaa tcttgctttt tgaaatgatt ctaaaagctt     1680

ctatcactgc tttgctctta agagccaaag ttgtaggcct tttgaaattt taggagagtg     1740

agcctataat ttcaagatac cttaaagagc aaaatttgag ccacctcttc caagtgccct     1800

tcttactaag tctattcaga atcaagctta aaaattacca ccagcaaaca atcttcatag     1860

cccatataac ttttatctat ttaattttat agtattgctt tataagacag cttagaagaa     1920

caataagcta tttgtattat gagctgaaca aaaagagaat cataggatag tagcgtctga     1980

ggccatcttt tctaggaata ggaaagagaa aaatgtattt gaattttgcc tttagatttg     2040

aaattaggtt aatagaaata agtaacccca tgtaattcac cttaaaactt aacaaaagac     2100

caaacattac aaaacccaga gatatagaat caatatagga tttgaaggcc cagcagacag     2160

ttttctatga caggttaatc tgaagtatcc tgtaatgttc attaagttac tgtgtttcca     2220

gaatctaaat tagatgagaa atataattgt ggttttctaa cttgataatc aaattatgtt     2280

aacatgggtc ctttagcttt taaaatgact tgctttgttt tagaaaggtg gtattaatcc     2340

actctctatt cttgaaaatt tggatgggag aattctgaag ttgcctgctg ttttccttta     2400

gcgctgaggt tcttaaggtt acttttatat tactctggaa tcaagtattt taaattgtat     2460

ttttttttta aatgatctct cagcaataat tgtttgaaac tatccatata taaggttatc     2520

agacctacag ttccctaaga ggaactgcat gttctcttca atcagaaata tacagtagaa     2580

gcaggtatat cttccatgca gtttcagtag taagcactac ttatacctac ataagagtta     2640

aaatccagat gtgggacctt ttgataccat cagtgatata tattttttta aactggtaca     2700

gagaagtgaa aagattaaat tctacttcta tttttttttt ttttttttga gacggagtct     2760

cgctctgtca ccaaggccgg agtgcagtgg tgcgatctcg gctcactgca agctccgcct     2820

cccaggttca cgtcattctc ctgcctcagc ctcccgacta gctgggacta caggcgccca     2880

ccaccacgcc cggctaattt ttttgtattt ttagtagaga cggggtttca ccatgttagc     2940

caggatggtc tcaatctcct gacctcatga tccgcccgtc ttggcctccc aaagtgctgg     3000

gattacaggc atgagcaact gcgcccagcc aaattctact tcttaaaaat cacaaaaact     3060

agtttaaatt gatgacttgt tcgtatgttc aaaatgtaac aacaaaaaaa gctaacacca     3120

gtcatttata ttaacttttt ttttttaaat caaaaattgt taatgttaga aacatactat     3180

gaagtgcctt tatctgctta gacctaagga agattttaaa gttgggttgc acaggaaatg     3240

atgatgcttc aatttcttaa tagttaaaaa gtgctaaata ctacttgaaa ttattgttta     3300

cagattagtg acaagagctg gggttaggat ccggttggac tctgacatcg gatgccctca     3360

aacatacaga acttccaaac tcaagtccag ccataagcta ttttgccaac atgtcagagt     3420

aatctgtatt tttgtatgtg atttctactt ttatagactt gttttaaaac aataaaacac     3480

atttttataa aaatgagtgc ttaaaaaaaa aaaaaaaaaa                           3520


<210> 3
<211> 414
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          


Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              


Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  


Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         


Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 


Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 


Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     


Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         


Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             


Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 


Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 


Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             


Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 


Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 


Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         


Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             


Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 


Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 


Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 


<210> 4
<211> 2402
<212> DNA
<213> Homo sapiens

<400> 4
gggctgagga ggcggggcct gggaggggac aaagccggga agaggaaaag ctcggaccta       60

ccctgtggtc ccgggtttct gcagagtcta cttcagaagc ggaggcactg ggagtccggt      120

ttgggattgc caggctgtgg ttgtgagtct gagcttgtga gcggctgtgg cgccccaact      180

cttcgccagc atatcatccc ggcaggcgat aaactacatt cagttgagtc tgcaagactg      240

ggaggaactg gggtgataag aaatctattc actgtcaagg tttattgaag tcaaaatgtc      300

caaaaaaatc agtggcggtt ctgtggtaga gatgcaagga gatgaaatga cacgaatcat      360

ttgggaattg attaaagaga aactcatttt tccctacgtg gaattggatc tacatagcta      420

tgatttaggc atagagaatc gtgatgccac caacgaccaa gtcaccaagg atgctgcaga      480

agctataaag aagcataatg ttggcgtcaa atgtgccact atcactcctg atgagaagag      540

ggttgaggag ttcaagttga aacaaatgtg gaaatcacca aatggcacca tacgaaatat      600

tctgggtggc acggtcttca gagaagccat tatctgcaaa aatatccccc ggcttgtgag      660

tggatgggta aaacctatca tcataggtcg tcatgcttat ggggatcaat acagagcaac      720

tgattttgtt gttcctgggc ctggaaaagt agagataacc tacacaccaa gtgacggaac      780

ccaaaaggtg acatacctgg tacataactt tgaagaaggt ggtggtgttg ccatggggat      840

gtataatcaa gataagtcaa ttgaagattt tgcacacagt tccttccaaa tggctctgtc      900

taagggttgg cctttgtatc tgagcaccaa aaacactatt ctgaagaaat atgatgggcg      960

ttttaaagac atctttcagg agatatatga caagcagtac aagtcccagt ttgaagctca     1020

aaagatctgg tatgagcata ggctcatcga cgacatggtg gcccaagcta tgaaatcaga     1080

gggaggcttc atctgggcct gtaaaaacta tgatggtgac gtgcagtcgg actctgtggc     1140

ccaagggtat ggctctctcg gcatgatgac cagcgtgctg gtttgtccag atggcaagac     1200

agtagaagca gaggctgccc acgggactgt aacccgtcac taccgcatgt accagaaagg     1260

acaggagacg tccaccaatc ccattgcttc catttttgcc tggaccagag ggttagccca     1320

cagagcaaag cttgataaca ataaagagct tgccttcttt gcaaatgctt tggaagaagt     1380

ctctattgag acaattgagg ctggcttcat gaccaaggac ttggctgctt gcattaaagg     1440

tttacccaat gtgcaacgtt ctgactactt gaatacattt gagttcatgg ataaacttgg     1500

agaaaacttg aagatcaaac tagctcaggc caaactttaa gttcatacct gagctaagaa     1560

ggataattgt cttttggtaa ctaggtctac aggtttacat ttttctgtgt tacactcaag     1620

gataaaggca aaatcaattt tgtaatttgt ttagaagcca gagtttatct tttctataag     1680

tttacagcct ttttcttata tatacagtta ttgccacctt tgtgaacatg gcaagggact     1740

tttttacaat ttttatttta ttttctagta ccagcctagg aattcggtta gtactcattt     1800

gtattcactg tcactttttc tcatgttcta attataaatg accaaaatca agattgctca     1860

aaagggtaaa tgatagccac agtattgctc cctaaaatat gcataaagta gaaattcact     1920

gccttcccct cctgtccatg accttgggca cagggaagtt ctggtgtcat agatatcccg     1980

ttttgtgagg tagagctgtg cattaaactt gcacatgact ggaacgaagt atgagtgcaa     2040

ctcaaatgtg ttgaagatac tgcagtcatt tttgtaaaga ccttgctgaa tgtttccaat     2100

agactaaata ctgtttaggc cgcaggagag tttggaatcc ggaataaata ctacctggag     2160

gtttgtcctc tccatttttc tctttctcct cctggcctgg cctgaatatt atactactct     2220

aaatagcata tttcatccaa gtgcaataat gtaagctgaa tcttttttgg acttctgctg     2280

gcctgtttta tttcttttat ataaatgtga tttctcagaa attgatatta aacactatct     2340

tatcttctcc tgaactgttg attttaatta aaattaagtg ctaattacca ttaaaaaaaa     2400

aa                                                                    2402


<210> 5
<211> 452
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly 
1               5                   10                  15      


Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln 
            20                  25                  30          


Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys 
        35                  40                  45              


Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
    50                  55                  60                  


Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys 
65                  70                  75                  80  


Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val 
                85                  90                  95      


Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
            100                 105                 110         


Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
        115                 120                 125             


Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
    130                 135                 140                 


Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
145                 150                 155                 160 


Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                165                 170                 175     


Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe 
            180                 185                 190         


Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu 
        195                 200                 205             


Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
    210                 215                 220                 


Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile 
225                 230                 235                 240 


Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys 
                245                 250                 255     


Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
            260                 265                 270         


His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg 
        275                 280                 285             


Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
    290                 295                 300                 


Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
305                 310                 315                 320 


Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                325                 330                 335     


Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
            340                 345                 350         


Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
        355                 360                 365             


Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
    370                 375                 380                 


Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys 
385                 390                 395                 400 


Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                405                 410                 415     


Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
            420                 425                 430         


Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
        435                 440                 445             


Leu Gly Arg Gln 
    450         


<210> 6
<211> 1818
<212> DNA
<213> Homo sapiens

<400> 6
tccccggcaa ggcccaatgg ggcggcaggc ccggcagccc cgccccggtg gtgcccgcgc       60

ggccagcgcc cgccaggccc agcgttagcc cgcggccagg cagccgggag gagcggcgcg      120

cgctcggacc tctcccgccc tgctcgttcg ctctccagct tgggatggcc ggctacctgc      180

gggtcgtgcg ctcgctctgc agagcctcag gctcgcggcc ggcctgggcg ccggcggccc      240

tgacagcccc cacctcgcaa gagcagccgc ggcgccacta tgccgacaaa aggatcaagg      300

tggcgaagcc cgtggtggag atggatggtg atgagatgac ccgtattatc tggcagttca      360

tcaaggagaa gctcatcctg ccccacgtgg acatccagct aaagtatttt gacctcgggc      420

tcccaaaccg tgaccagact gatgaccagg tcaccattga ctctgcactg gccacccaga      480

agtacagtgt ggctgtcaag tgtgccacca tcacccctga tgaggcccgt gtggaagagt      540

tcaagctgaa gaagatgtgg aaaagtccca atggaactat ccggaacatc ctggggggga      600

ctgtcttccg ggagcccatc atctgcaaaa acatcccacg cctagtccct ggctggacca      660

agcccatcac cattggcagg cacgcccatg gcgaccagta caaggccaca gactttgtgg      720

cagaccgggc cggcactttc aaaatggtct tcaccccaaa agatggcagt ggtgtcaagg      780

agtgggaagt gtacaacttc cccgcaggcg gcgtgggcat gggcatgtac aacaccgacg      840

agtccatctc aggttttgcg cacagctgct tccagtatgc catccagaag aaatggccgc      900

tgtacatgag caccaagaac accatactga aagcctacga tgggcgtttc aaggacatct      960

tccaggagat ctttgacaag cactataaga ccgacttcga caagaataag atctggtatg     1020

agcaccggct cattgatgac atggtggctc aggtcctcaa gtcttcgggt ggctttgtgt     1080

gggcctgcaa gaactatgac ggagatgtgc agtcagacat cctggcccag ggctttggct     1140

cccttggcct gatgacgtcc gtcctggtct gccctgatgg gaagacgatt gaggctgagg     1200

ccgctcatgg gaccgtcacc cgccactatc gggagcacca gaagggccgg cccaccagca     1260

ccaaccccat cgccagcatc tttgcctgga cacgtggcct ggagcaccgg gggaagctgg     1320

atgggaacca agacctcatc aggtttgccc agatgctgga gaaggtgtgc gtggagacgg     1380

tggagagtgg agccatgacc aaggacctgg cgggctgcat tcacggcctc agcaatgtga     1440

agctgaacga gcacttcctg aacaccacgg acttcctcga caccatcaag agcaacctgg     1500

acagagccct gggcaggcag tagggggagg cgccacccat ggctgcagtg gaggggccag     1560

ggctgagccg gcgggtcctc ctgagcgcgg cagagggtga gcctcacagc ccctctctgg     1620

aggcctttct aggggatgtt tttttataag ccagatgttt ttaaaagcat atgtgtgttt     1680

cccctcatgg tgacgtgagg caggagcagt gcgttttacc tcagccagtc agtatgtttt     1740

gcatactgta atttatattg cccttggaac acatggtgcc atatttagct actaaaaagc     1800

tcttcacaaa aaaaaaaa                                                   1818


<210> 7
<211> 531
<212> PRT
<213> Homo sapiens

<400> 7
Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Met Phe His Arg Lys Leu Phe Glu Glu Leu Val Arg 
385                 390                 395                 400 


Ala Ser Ser His Ser Thr Asp Leu Met Glu Ala Met Ala Met Gly Ser 
                405                 410                 415     


Val Glu Ala Ser Tyr Lys Cys Leu Ala Ala Ala Leu Ile Val Leu Thr 
            420                 425                 430         


Glu Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210> 8
<211> 2754
<212> DNA
<213> Homo sapiens

<400> 8
aacccataaa tctgggccct gcccaggtag gccgggacag ctggggtggc ctgggccgag       60

agccaagaaa agacacccca tctggcagcc caacttggcg gcaacaggtg gcccggcgcc      120

cgggggtctg ggaggaaagt cgctccgggg gcgggccccg ttgccccgcc gcgtccccat      180

tggtcatcag gtttcttaaa atgtgactct gaatctgtgt ccttccgccg cagaatttag      240

tcccaccgaa agggcaacct gcccgcgcgt tccgccaccg ccgccgcgct tcctcctgaa      300

ggtgactgcg cccgcgggga cgcagggggc ggggcccggg tcgcccggag ccgggattgg      360

gcagagggcg gggcggcgga gggattgcgg cggcccgcag cgggataacc ttgaggctga      420

ggcagtggct ccttgcacag cagctgcacg cgccgtggct ccggatctct tcgtctttgc      480

agcgtagccc gagtcggtca gcgccggagg acctcagcag ccatgtcgaa gccccatagt      540

gaagccggga ctgccttcat tcagacccag cagctgcacg cagccatggc tgacacattc      600

ctggagcaca tgtgccgcct ggacattgat tcaccaccca tcacagcccg gaacactggc      660

atcatctgta ccattggccc agcttcccga tcagtggaga cgttgaagga gatgattaag      720

tctggaatga atgtggctcg tctgaacttc tctcatggaa ctcatgagta ccatgcggag      780

accatcaaga atgtgcgcac agccacggaa agctttgctt ctgaccccat cctctaccgg      840

cccgttgctg tggctctaga cactaaagga cctgagatcc gaactgggct catcaagggc      900

agcggcactg cagaggtgga gctgaagaag ggagccactc tcaaaatcac gctggataac      960

gcctacatgg aaaagtgtga cgagaacatc ctgtggctgg actacaagaa catctgcaag     1020

gtggtggaag tgggcagcaa gatctacgtg gatgatgggc ttatttctct ccaggtgaag     1080

cagaaaggtg ccgacttcct ggtgacggag gtggaaaatg gtggctcctt gggcagcaag     1140

aagggtgtga accttcctgg ggctgctgtg gacttgcctg ctgtgtcgga gaaggacatc     1200

caggatctga agtttggggt cgagcaggat gttgatatgg tgtttgcgtc attcatccgc     1260

aaggcatctg atgtccatga agttaggaag gtcctgggag agaagggaaa gaacatcaag     1320

attatcagca aaatcgagaa tcatgagggg gttcggaggt ttgatgaaat cctggaggcc     1380

agtgatggga tcatggtggc tcgtggtgat ctaggcattg agattcctgc agagaaggtc     1440

ttccttgctc agaagatgat gattggacgg tgcaaccgag ctgggaagcc tgtcatctgt     1500

gctactcaga tgctggagag catgatcaag aagccccgcc ccactcgggc tgaaggcagt     1560

gatgtggcca atgcagtcct ggatggagcc gactgcatca tgctgtctgg agaaacagcc     1620

aaaggggact atcctctgga ggctgtgcgc atgcagcacc tgatagctcg tgaggctgag     1680

gcagccatgt tccaccgcaa gctgtttgaa gaacttgtgc gagcctcaag tcactccaca     1740

gacctcatgg aagccatggc catgggcagc gtggaggctt cttataagtg tttagcagca     1800

gctttgatag ttctgacgga gtctggcagg tctgctcacc aggtggccag ataccgccca     1860

cgtgccccca tcattgctgt gacccggaat ccccagacag ctcgtcaggc ccacctgtac     1920

cgtggcatct tccctgtgct gtgcaaggac ccagtccagg aggcctgggc tgaggacgtg     1980

gacctccggg tgaactttgc catgaatgtt ggcaaggccc gaggcttctt caagaaggga     2040

gatgtggtca ttgtgctgac cggatggcgc cctggctccg gcttcaccaa caccatgcgt     2100

gttgttcctg tgccgtgatg gaccccagag cccctcctcc agcccctgtc ccaccccctt     2160

cccccagccc atccattagg ccagcaacgc ttgtagaact cactctgggc tgtaacgtgg     2220

cactggtagg ttgggacacc agggaagaag atcaacgcct cactgaaaca tggctgtgtt     2280

tgcagcctgc tctagtggga cagcccagag cctggctgcc catcatgtgg ccccacccaa     2340

tcaagggaag aaggaggaat gctggactgg aggcccctgg agccagatgg caagagggtg     2400

acagcttcct ttcctgtgtg tactctgtcc agttccttta gaaaaaatgg atgcccagag     2460

gactcccaac cctggcttgg ggtcaagaaa cagccagcaa gagttagggg ccttagggca     2520

ctgggctgtt gttccattga agccgactct ggccctggcc cttacttgct tctctagctc     2580

tctaggcctc tccagtttgc acctgtcccc accctccact cagctgtcct gcagcaaaca     2640

ctccaccctc caccttccat tttcccccac tactgcagca cctccaggcc tgttgctata     2700

gagcctacct gtatgtcaat aaacaacagc tgaagcacca aaaaaaaaaa aaaa           2754


<210> 9
<211> 22
<212> PRT
<213> Homo sapiens

<400> 9
Thr Ile Thr Pro Asp Glu Lys Arg Val Glu Glu Phe Lys Leu Lys Gln 
1               5                   10                  15      


Met Trp Lys Ser Pro Asn 
            20          


<210> 10
<211> 22
<212> PRT
<213> Mus sp.

<400> 10
Thr Ile Thr Pro Asp Glu Lys Arg Val Glu Glu Phe Lys Leu Lys Gln 
1               5                   10                  15      


Met Trp Lys Ser Pro Asn 
            20          


<210> 11
<211> 22
<212> PRT
<213> Rattus sp.

<400> 11
Thr Ile Thr Pro Asp Glu Lys Arg Val Glu Glu Phe Lys Leu Lys Gln 
1               5                   10                  15      


Met Trp Lys Ser Pro Asn 
            20          


<210> 12
<211> 22
<212> PRT
<213> Homo sapiens

<400> 12
Thr Ile Thr Pro Asp Glu Lys Arg Val Glu Glu Phe Lys Leu Lys Lys 
1               5                   10                  15      


Met Trp Lys Ser Pro Asn 
            20          


<210> 13
<211> 22
<212> PRT
<213> Mus sp.

<400> 13
Thr Ile Thr Pro Asp Glu Lys Arg Val Glu Glu Phe Lys Leu Lys Lys 
1               5                   10                  15      


Met Trp Lys Ser Pro Asn 
            20          


<210> 14
<211> 22
<212> PRT
<213> Rattus sp.

<400> 14
Thr Ile Thr Pro Asp Glu Lys Arg Val Glu Glu Phe Lys Leu Lys Lys 
1               5                   10                  15      


Met Trp Lys Ser Pro Asn 
            20          


<210> 15
<211> 12
<212> PRT
<213> Homo sapiens

<400> 15
Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp Gly 
1               5                   10          


<210> 16
<211> 12
<212> PRT
<213> Mus sp.

<400> 16
Gly Lys Val Glu Ile Thr Tyr Thr Pro Lys Asp Gly 
1               5                   10          


<210> 17
<211> 12
<212> PRT
<213> Rattus sp.

<400> 17
Gly Lys Val Glu Ile Thr Tyr Thr Pro Lys Asp Gly 
1               5                   10          


<210> 18
<211> 12
<212> PRT
<213> Homo sapiens

<400> 18
Gly Thr Phe Lys Met Val Phe Thr Pro Lys Asp Gly 
1               5                   10          


<210> 19
<211> 12
<212> PRT
<213> Mus sp.

<400> 19
Gly Thr Phe Lys Met Val Phe Thr Pro Lys Asp Gly 
1               5                   10          


<210> 20
<211> 12
<212> PRT
<213> Rattus sp.

<400> 20
Gly Thr Phe Lys Met Val Phe Thr Pro Lys Asp Gly 
1               5                   10          


<210> 21
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> N-term Biotin

<400> 21
Thr Asp Phe Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr 
1               5                   10                  15      


Pro Ser Asp Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe 
            20                  25                  30      


<210> 22
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> N-term Biotin

<220>
<221> MOD_RES
<222> (16)..(16)
<223> PhosphoThr

<400> 22
Thr Asp Phe Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr 
1               5                   10                  15      


Pro Ser Asp Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe 
            20                  25                  30      


<210> 23
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> N-term Biotin

<400> 23
Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe Lys Met Val Phe Thr 
1               5                   10                  15      


Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu Val Tyr Asn Phe 
            20                  25                  30      


<210> 24
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> N-term Biotin

<220>
<221> MOD_RES
<222> (16)..(16)
<223> PhosphoThr

<400> 24
Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe Lys Met Val Phe Thr 
1               5                   10                  15      


Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu Val Tyr Asn Phe 
            20                  25                  30      


<210> 25
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      IDH1 sequence


<220>
<221> MOD_RES
<222> (6)..(6)
<223> PhosphoThr

<400> 25
Val Glu Ile Thr Tyr Thr Pro Ser Asp Gly Thr Gln Lys 
1               5                   10              


<210> 26
<211> 24
<212> PRT
<213> Homo sapiens

<400> 26
Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Ala His 
1               5                   10                  15      


Arg Ala Lys Leu Asp Asn Asn Lys 
            20                  


<210> 27
<211> 24
<212> PRT
<213> Mus sp.

<400> 27
Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp Ser Arg Gly Leu Ala His 
1               5                   10                  15      


Arg Ala Lys Leu Asp Asn Asn Thr 
            20                  


<210> 28
<211> 24
<212> PRT
<213> Rattus sp.

<400> 28
Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp Ser Arg Gly Leu Ala His 
1               5                   10                  15      


Arg Ala Lys Leu Asp Asn Asn Thr 
            20                  


<210> 29
<211> 24
<212> PRT
<213> Homo sapiens

<400> 29
Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His 
1               5                   10                  15      


Arg Gly Lys Leu Asp Gly Asn Gln 
            20                  


<210> 30
<211> 22
<212> PRT
<213> Homo sapiens

<400> 30
Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu Phe Gly Pro 
1               5                   10                  15      


Val Asp His Glu Glu Leu 
            20          


<210> 31
<211> 21
<212> PRT
<213> Homo sapiens

<400> 31
Arg Gln Met Asn Pro Cys Phe Ser Lys Ala Arg Arg Leu Phe Gly Pro 
1               5                   10                  15      


Val Asp Ser Glu Gln 
            20      


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
tacgaaatat tctgggtggc                                                   20


