                         SEQUENCE LISTING

<110>  Phanes Therapeutics, Inc.
 
<120>  Anti-Claudin 18.2 Antibodies and Uses Thereof

<130>  689204.9WO

<150>  US 62/640,288
<151>  2018-03-08

<150>  US 62/714,254
<151>  2018-08-03

<160>  165   

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 Heavy Chain Variable Region

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Ser Arg Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 Light Chain Variable Region

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  3
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 Heavy Chain Variable Region

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Gly Asn Tyr Val Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Lys Val Ser Ser 
        115         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 Light Chain Variable Region

<400>  4

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Arg Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Phe Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 Heavy Chain Variable Region

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Gly Gly Ser Tyr Thr Tyr Cys Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Lys Gly Asn Ala Leu Asp Tyr Trp Gly Gln Gly Asn 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 Light Chain Variable Region

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ser Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 Heavy Chain Variable Region

<400>  7

Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Phe Gly Ser Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 Light Chain Variable Region

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Gly Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  9
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 Heavy Chain Variable Region

<400>  9

Lys Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Asn 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Pro Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 Light Chain Variable Region

<400>  10

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Arg Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Ser Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 Heavy Chain Variable Region

<400>  11

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Arg Ser Thr Met Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Asn Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 Light Chain Variable Region

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Leu Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Met Gln Ala Glu Asp Leu Ala Val Tyr Ser Cys Gln Asn 
                85                  90                  95      


Ala Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  13
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 Heavy Chain Variable Region

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Tyr Gly Asp Thr Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Thr Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 Light Chain Variable Region

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Thr Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Ala Tyr Ile Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  15
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 Heavy Chain Variable Region

<400>  15

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asn Tyr Gly Asn Cys Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 Light Chain Variable Region

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Thr Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Phe Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  17
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 Heavy Chain Variable Region

<400>  17

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ile Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 Light Chain Variable Region

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  19
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 Heavy Chain Variable Region

<400>  19

Gln Val Gln Leu Gln Gln Pro Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Arg Ser Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Leu Ser Arg Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  20
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 Light Chain Variable Region

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Ser Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Tyr Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 HC CDR1

<400>  21

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 HC CDR2

<400>  22

Ile Ser Gly Gly Gly Ser Tyr Thr 
1               5               


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 HC CDR3

<400>  23

Ala Arg Gln Ser Arg Gly Asn Ala Met Asp Tyr 
1               5                   10      


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 HC CDR1

<400>  24

Gly Tyr Ser Phe Thr Gly Tyr Asn 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 HC CDR2

<400>  25

Ile Asp Pro Tyr Asn Gly Val Thr 
1               5               


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 HC CDR3

<400>  26

Ala Arg Trp Gly Gly Asn Tyr Val Asp Tyr 
1               5                   10  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 HC CDR1

<400>  27

Gly Phe Thr Phe Ser Lys Tyr Ala 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 HC CDR2

<400>  28

Ile Ser Asn Gly Gly Ser Tyr Thr 
1               5               


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 HC CDR3

<400>  29

Ala Arg His Asp Lys Gly Asn Ala Leu Asp Tyr 
1               5                   10      


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 HC CDR1

<400>  30

Gly Tyr Ser Phe Thr Gly Tyr Asn 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 HC CDR2

<400>  31

Ile Asn Pro Tyr Phe Gly Ser Thr 
1               5               


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 HC CDR3

<400>  32

Ala Arg Gly Ala Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   10          


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 HC CDR1

<400>  33

Gly Tyr Thr Ile Thr Asp Asn Tyr 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 HC CDR2

<400>  34

Ile Tyr Pro Gly Ser Gly Asn Thr 
1               5               


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 HC CDR3

<400>  35

Ala Arg Gly Phe Pro Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 HC CDR1

<400>  36

Gly Phe Ile Phe Ser Ser Phe Gly 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 HC CDR2

<400>  37

Ile Ser Ser Gly Arg Ser Thr Met 
1               5               


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 HC CDR3

<400>  38

Ala Arg Gly Gly Phe Tyr Gly Asn Ser Leu Asp Tyr 
1               5                   10          


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 HC CDR1

<400>  39

Gly Tyr Ala Phe Ser Asp Tyr Trp 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 HC CDR2

<400>  40

Ile Tyr Pro Gly Tyr Gly Asp Thr 
1               5               


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 HC CDR3

<400>  41

Ala Arg Trp Gly Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   10          


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 HC CDR1

<400>  42

Gly Tyr Thr Phe Thr Arg Tyr Arg 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 HC CDR2

<400>  43

Ile Asp Pro Ser Asp Ser Glu Thr 
1               5               


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 HC CDR3

<400>  44

Ala Arg Leu Asn Tyr Gly Asn Cys Phe Asp Tyr 
1               5                   10      


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 HC CDR1

<400>  45

Gly Tyr Ala Phe Thr Ser Tyr Val 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 HC CDR2

<400>  46

Ile Asn Pro Tyr Ser Asp Gly Thr 
1               5               


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 HC CDR3

<400>  47

Thr Arg Ile Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   10      


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 HC CDR1

<400>  48

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 HC CDR2

<400>  49

Ile Tyr Pro Gly Arg Ser Ser Thr 
1               5               


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 HC CDR3

<400>  50

Ser Arg Leu Ser Arg Gly Asn Ala Met Asp Tyr 
1               5                   10      


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 LC CDR1

<400>  51

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  52
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 LC CDR2

<400>  52

Trp Ala Ser 
1           


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 LC CDR3

<400>  53

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 LC CDR1

<400>  54

Gln Asp Ile Asn Arg Tyr 
1               5       


<210>  55
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 LC CDR2

<400>  55

Arg Ala Asn 
1           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 LC CDR3

<400>  56

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 LC CDR1

<400>  57

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  58
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 LC CDR2

<400>  58

Trp Ala Ser 
1           


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 LC CDR3

<400>  59

Gln Asn Asp Tyr Phe Tyr Pro Leu Thr 
1               5                   


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 LC CDR1

<400>  60

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  61
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 LC CDR2

<400>  61

Trp Ala Ser 
1           


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 LC CDR3

<400>  62

Gln Asn Asp Tyr Phe Tyr Pro Leu Thr 
1               5                   


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 LC CDR1

<400>  63

Gln Asn Ile Asn Val Trp 
1               5       


<210>  64
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 LC CDR2

<400>  64

Lys Ala Ser 
1           


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 LC CDR3

<400>  65

Gln Gln Gly Gln Asn Tyr Pro Leu Thr 
1               5                   


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 LC CDR1

<400>  66

Leu Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  67
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 LC CDR2

<400>  67

Trp Ala Ser 
1           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 LC CDR3

<400>  68

Gln Asn Ala Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 LC CDR1

<400>  69

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  70
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 LC CDR2

<400>  70

Trp Ala Ser 
1           


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 LC CDR3

<400>  71

Gln Asn Ala Tyr Ile Tyr Pro Leu Thr 
1               5                   


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 LC CDR1

<400>  72

Gln Thr Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  73
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 LC CDR2

<400>  73

Trp Ala Ser 
1           


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 LC CDR3

<400>  74

Gln Asn Asp Tyr Phe Tyr Pro Phe Thr 
1               5                   


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 LC CDR1

<400>  75

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  76
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 LC CDR2

<400>  76

Trp Ala Ser 
1           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 LC CDR3

<400>  77

Gln Asn Asp Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 LC CDR1

<400>  78

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Ser Tyr 
1               5                   10          


<210>  79
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 LC CDR2

<400>  79

Trp Ala Ser 
1           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 LC CDR3

<400>  80

Gln Asn Asp Tyr Tyr Tyr Pro Phe Thr 
1               5                   


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 HC CDR1

<400>  81

Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 HC CDR2

<400>  82

Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 HC CDR3

<400>  83

Ala Arg Gln Ser Arg Gly Asn Ala Met Asp Tyr 
1               5                   10      


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 HC CDR1

<400>  84

Gly Tyr Ser Phe Thr Gly Tyr Asn Met His 
1               5                   10  


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 HC CDR2

<400>  85

Tyr Ile Asp Pro Tyr Asn Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 HC CDR3

<400>  86

Ala Arg Trp Gly Gly Asn Tyr Val Asp Tyr 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 HC CDR1

<400>  87

Gly Phe Thr Phe Ser Lys Tyr Ala Met Ser 
1               5                   10  


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 HC CDR2

<400>  88

Phe Ile Ser Asn Gly Gly Ser Tyr Thr Tyr Cys Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 HC CDR3

<400>  89

Ala Arg His Asp Lys Gly Asn Ala Leu Asp Tyr 
1               5                   10      


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 HC CDR1

<400>  90

Gly Tyr Ser Phe Thr Gly Tyr Asn Met Lys 
1               5                   10  


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 HC CDR2

<400>  91

Asn Ile Asn Pro Tyr Phe Gly Ser Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 HC CDR3

<400>  92

Ala Arg Gly Ala Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   10          


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 HC CDR1

<400>  93

Gly Tyr Thr Ile Thr Asp Asn Tyr Met His 
1               5                   10  


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 HC CDR2

<400>  94

Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 HC CDR3

<400>  95

Ala Arg Gly Phe Pro Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 HC CDR1

<400>  96

Gly Phe Ile Phe Ser Ser Phe Gly Met His 
1               5                   10  


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 HC CDR2

<400>  97

Tyr Ile Ser Ser Gly Arg Ser Thr Met Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 HC CDR3

<400>  98

Ala Arg Gly Gly Phe Tyr Gly Asn Ser Leu Asp Tyr 
1               5                   10          


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 HC CDR1

<400>  99

Gly Tyr Ala Phe Ser Asp Tyr Trp Met Asn 
1               5                   10  


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 HC CDR2

<400>  100

Gln Ile Tyr Pro Gly Tyr Gly Asp Thr Lys Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 HC CDR3

<400>  101

Ala Arg Trp Gly Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   10          


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 HC CDR1

<400>  102

Gly Tyr Thr Phe Thr Arg Tyr Arg Met Asn 
1               5                   10  


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 HC CDR2

<400>  103

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 HC CDR3

<400>  104

Ala Arg Leu Asn Tyr Gly Asn Cys Phe Asp Tyr 
1               5                   10      


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 HC CDR1

<400>  105

Gly Tyr Ala Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  106
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 HC CDR2

<400>  106

Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Arg Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 HC CDR3

<400>  107

Thr Arg Ile Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   10      


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 HC CDR1

<400>  108

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn 
1               5                   10  


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 HC CDR2

<400>  109

Asn Ile Tyr Pro Gly Arg Ser Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 HC CDR3

<400>  110

Ser Arg Leu Ser Arg Gly Asn Ala Met Asp Tyr 
1               5                   10      


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 LC CDR1

<400>  111

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 LC CDR2

<400>  112

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3 LC CDR3

<400>  113

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 LC CDR1

<400>  114

Lys Ala Ser Gln Asp Ile Asn Arg Tyr Leu Ser 
1               5                   10      


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 LC CDR2

<400>  115

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P8 LC CDR3

<400>  116

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  117
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 LC CDR1

<400>  117

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 LC CDR2

<400>  118

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21 LC CDR3

<400>  119

Gln Asn Asp Tyr Phe Tyr Pro Leu Thr 
1               5                   


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 LC CDR1

<400>  120

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 LC CDR2

<400>  121

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21 LC CDR3

<400>  122

Gln Asn Asp Tyr Phe Tyr Pro Leu Thr 
1               5                   


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 LC CDR1

<400>  123

His Ala Arg Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 LC CDR2

<400>  124

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22 LC CDR3

<400>  125

Gln Gln Gly Gln Asn Tyr Pro Leu Thr 
1               5                   


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 LC CDR1

<400>  126

Lys Ser Ser Leu Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 LC CDR2

<400>  127

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11 LC CDR3

<400>  128

Gln Asn Ala Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 LC CDR1

<400>  129

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 LC CDR2

<400>  130

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-G12 LC CDR3

<400>  131

Gln Asn Ala Tyr Ile Tyr Pro Leu Thr 
1               5                   


<210>  132
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 LC CDR1

<400>  132

Lys Ser Ser Gln Thr Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 LC CDR2

<400>  133

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J10 LC CDR3

<400>  134

Gln Asn Asp Tyr Phe Tyr Pro Phe Thr 
1               5                   


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 LC CDR1

<400>  135

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 LC CDR2

<400>  136

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-K2 LC CDR3

<400>  137

Gln Asn Asp Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  138
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 LC CDR1

<400>  138

Arg Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Ser Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 LC CDR2

<400>  139

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-D6 LC CDR3

<400>  140

Gln Asn Asp Tyr Tyr Tyr Pro Phe Thr 
1               5                   


<210>  141
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ala Val Thr Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile 
1               5                   10                  15      


Gly Ile Ala Gly Ile Ile Ala Ala Thr Cys Met Asp Gln Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  142
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3-H1 Heavy Chain Variable Region

<400>  142

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Ile Ser Ala Asn Gln Leu Val 
65                  70                  75                  80  


Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Ser Arg Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  143
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3-H2 Heavy Chain Variable Region

<400>  143

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Leu Asp Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Ser Arg Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  144
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3-L1 Light Chain Variable Region

<400>  144

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  145
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-C3-L2 Light Chain Variable Region

<400>  145

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  146
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22-H1 Heavy Chain Variable Region

<400>  146

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Asn 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  147
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22-H3 Heavy Chain Variable Region

<400>  147

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Asn 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  148
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22-L1 Light Chain Variable Region

<400>  148

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys His Ala Arg Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  149
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22-L2 Light Chain Variable Region

<400>  149

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys His Ala Arg Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  150
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-E22-L3 Light Chain Variable Region

<400>  150

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys His Ala Arg Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Gly Gln Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  151
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11-H1 Heavy Chain Variable Region

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Arg Ser Thr Met Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Asn Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  152
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11-H2 Heavy Chain Variable Region

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Arg Ser Thr Met Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Asn Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  153
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-J11-L1 Light Chain Variable Region

<400>  153

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Leu Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Ser Cys Gln Asn 
                85                  90                  95      


Ala Tyr Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  154
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21-H1 Heavy Chain Variable Region

<400>  154

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Gly Gly Ser Tyr Thr Glu Tyr Asn Pro Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Leu Arg Asp Asn Ser Lys Asn Gln Leu Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Lys Gly Asn Ala Leu Asp Tyr Trp Gly Gln Gly Ser 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  155
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21-H2 Heavy Chain Variable Region

<400>  155

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Gly Gly Ser Tyr Thr Glu Tyr Asn Pro Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Leu Arg Asp Asn Ser Lys Asn Gln Leu Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Lys Gly Asn Ala Leu Asp Tyr Trp Gly Gln Gly Ser 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  156
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21-H3 Heavy Chain Variable Region

<400>  156

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Asn Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Lys Gly Asn Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  157
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21-L1 Light Chain Variable Region

<400>  157

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Asn Leu Gln Thr Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  158
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E21-L2 Light Chain Variable Region

<400>  158

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  159
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21-H1 Heavy Chain Variable Region

<400>  159

Glu Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Phe Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  160
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21-H2 Heavy Chain Variable Region

<400>  160

Glu Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Phe Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  161
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21-H3 Heavy Chain Variable Region

<400>  161

Glu Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Tyr Phe Gly Ser Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  162
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21-H4 Heavy Chain Variable Region

<400>  162

Glu Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Lys Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asn Pro Tyr Phe Gly Ser Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  163
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21-L1 Light Chain Variable Region

<400>  163

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Val Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Phe Leu Tyr Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  164
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21-L2 Light Chain Variable Region

<400>  164

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Val Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  165
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P21-L3 Light Chain Variable Region

<400>  165

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


