                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
      ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
 
<120> COMPOSITIONS AND METHODS FOR DELIVERING NUCLEIC ACIDS TO COCHLEAR
      AND VESTIBULAR CELLS

<130> 167705.015301/PCT

<140> PCT/US2019/020794
<141> 2019-03-05

<150> 62/638,697
<151> 2018-03-05

<160> 27    

<170> PatentIn version 3.5

<210> 1
<211> 8543
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
ccaatgatac gcgtcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg       60

tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac      120

gacggccagt gagcgcgcgt aatacgactc actatagggc gaattgggta catcgacggt      180

atcgggggag ctcgcagggt ctccattttg aagcgggagg tttgaacgcg cagccgccat      240

gccggggttt tacgagattg tgattaaggt ccccagcgac cttgacgagc atctgcccgg      300

catttctgac agctttgtga actgggtggc cgagaaggaa tgggagttgc cgccagattc      360

tgacatggat ctgaatctga ttgagcaggc acccctgacc gtggccgaga agctgcagcg      420

cgactttctg acggaatggc gccgtgtgag taaggccccg gaggctcttt tctttgtgca      480

atttgagaag ggagagagct acttccacat gcacgtgctc gtggaaacca ccggggtgaa      540

atccatggtt ttgggacgtt tcctgagtca gattcgcgaa aaactgattc agagaattta      600

ccgcgggatc gagccgactt tgccaaactg gttcgcggtc acaaagacca gaaatggcgc      660

cggaggcggg aacaaggtgg tggatgagtg ctacatcccc aattacttgc tccccaaaac      720

ccagcctgag ctccagtggg cgtggactaa tatggaacag tatttaagcg cctgtttgaa      780

tctcacggag cgtaaacggt tggtggcgca gcatctgacg cacgtgtcgc agacgcagga      840

gcagaacaaa gagaatcaga atcccaattc tgatgcgccg gtgatcagat caaaaacttc      900

agccaggtac atggagctgg tcgggtggct cgtggacaag gggattacct cggagaagca      960

gtggatccag gaggaccagg cctcatacat ctccttcaat gcggcctcca actcgcggtc     1020

ccaaatcaag gctgccttgg acaatgcggg aaagattatg agcctgacta aaaccgcccc     1080

cgactacctg gtgggccagc agcccgtgga ggacatttcc agcaatcgga tttataaaat     1140

tttggaacta aacgggtacg atccccaata tgcggcttcc gtctttctgg gatgggccac     1200

gaaaaagttc ggcaagagga acaccatctg gctgtttggg cctgcaacta ccgggaagac     1260

caacatcgcg gaggccatag cccacactgt gcccttctac gggtgcgtaa actggaccaa     1320

tgagaacttt cccttcaacg actgtgtgga caagatggtg atctggtggg aggaggggaa     1380

gatgaccgcc aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt     1440

ggaccagaaa tgcaagtcct cggcccagat agacccgact cccgtgatcg tcacctccaa     1500

caccaatatg tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt     1560

gcaagaccgg atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt     1620

caccaagcag gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga     1680

gcatgaattc tacgtcaaaa agggtggagc caagaaaaga cccgccccca gtgacgcaga     1740

tataagtgag cccaaacggg tgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga     1800

agcttcgatc aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa     1860

tctgatgctg tttccctgca gacaatgcga gagactgaat cagaattcaa atatctgctt     1920

cactcacggt gtcaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc     1980

tgtcgtcaaa aaggcgtatc agaaactgtg ctacattcat cacatcatgg gaaaggtgcc     2040

agacgcttgc actgcttgcg acctggtcaa tgtggacttg gatgactgtg tttctgaaca     2100

ataaatgact taaaccaggt atgagtcggc tggataaatc taaagtcata aacggcgctc     2160

tggaattact caatgaagtc ggtatcgaag gcctgacgac aaggaaactc gctcaaaagc     2220

tgggagttga gcagcctacc ctgtactggc acgtgaagaa caagcgggcc ctgctcgatg     2280

ccctggccat cgagatgctg gacaggcatc atacccactt ctgccccctg gaaggcgagt     2340

catggcaaga ctttctgcgg aacaacgcca agtcattccg ctgtgctctc ctctcacatc     2400

gcgacggggc taaagtgcat ctcggcaccc gcccaacaga gaaacagtac gaaaccctgg     2460

aaaatcagct cgcgttcctg tgtcagcaag gcttctccct ggagaacgca ctgtacgctc     2520

tgtccgccgt gggccacttt acactgggct gcgtattgga ggaacaggag catcaagtag     2580

caaaagagga aagagagaca cctaccaccg attctatgcc cccacttctg agacaagcaa     2640

ttgagctgtt cgaccggcag ggagccgaac ctgccttcct tttcggcctg gaactaatca     2700

tatgtggcct ggagaaacag ctaaagtgcg aaagcggcgg gccggccgac gcccttgacg     2760

attttgactt agacatgctc ccagccgatg cccttgacga ctttgacctt gatatgctgc     2820

ctgctgacgc tcttgacgat tttgaccttg acatgctccc cgggtaaatg catgaattcg     2880

atctagaggg ccctattcta tagtgtcacc taaatgctag agctcgctga tcagcctcga     2940

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     3000

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     3060

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     3120

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa     3180

gaaccagctg gggctcgaat caagctatca agtgccacct gacgtctccc tatcagtgat     3240

agagaagtcg acacgtctcg agctccctat cagtgataga gaaggtacgt ctagaacgtc     3300

tccctatcag tgatagagaa gtcgacacgt ctcgagctcc ctatcagtga tagagaaggt     3360

acgtctagaa cgtctcccta tcagtgatag agaagtcgac acgtctcgag ctccctatca     3420

gtgatagaga aggtacgtct agaacgtctc cctatcagtg atagagaagt cgacacgtct     3480

cgagctccct atcagtgata gagaaggtac cccctatata agcagagaga tctgttcaaa     3540

tttgaactga ctaagcggct cccgccagat tttggcaaga ttactaagca ggaagtcaag     3600

gacttttttg cttgggcaaa ggtcaatcag gtgccggtga ctcacgagtt taaagttccc     3660

agggaattgg cgggaactaa aggggcggag aaatctctaa aacgcccact gggtgacgtc     3720

accaatacta gctataaaag tctggagaag cgggccaggc tctcatttgt tcccgagacg     3780

cctcgcagtt cagacgtgac tgttgatccc gctcctctgc gaccgctagc ttcgatcaac     3840

tacgcagaca ggtaccaaaa caagtgttct cgtcacgtgg gcattaatct gattctgttt     3900

ccctgcagac aatgcgagag aatgaatcag aactcaaata tctgcttcac tcacggacag     3960

aaagactgtt tagagtgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcaaaaag     4020

gcgtatcaga aactgtgcta cattcatcat atcatgggaa aggtgccaga cgcttgcact     4080

gcctgcgatc tggtcaatgt ggatttggat gactgcatct ttgaacaata aatgacttaa     4140

gccaggtatg gctgccgatg gttatcttcc agattggctc gaggacaacc ttagtgaagg     4200

aattcgcgag tggtgggctt tgaaacctgg agcccctcaa cccaaggcaa atcaacaaca     4260

tcaagacaac gctagaggtc ttgtgcttcc gggttacaaa taccttggac ccggcaacgg     4320

actcgacaag ggggagccgg tcaacgcagc agacgcggcg gccctcgagc acgacaaagc     4380

ctacgaccag cagctcaagg ccggagacaa cccgtacctc aagtacaacc acgccgacgc     4440

cgagttccag gagcggctca aagaagatac gtcttttggg ggcaacctcg ggcgagcagt     4500

cttccaggcc aaaaagaggc ttcttgaacc tcttggtctg gttgaggaag cggctaagac     4560

ggctcctgga aagaagaggc ctgtagagca gtctcctcag gaaccggact cctccgcggg     4620

tattggcaaa tcgggtgcac agcccgctaa aaagagactc aatttcggtc agactggcga     4680

cacagagtca gtcccagacc ctcaaccaat cggagaacct cccgcagccc cctcaggtgt     4740

gggatctctt acaatggctt caggtggtgg cgcaccagtg gcagacaata acgaaggtgc     4800

cgatggagtg ggtagttcct cgggaaattg gcattgcgat tcccaatggc tgggggacag     4860

agtcatcacc accagcaccc gaacctgggc cctgcccacc tacaacaatc acctctacaa     4920

gcaaatctcc aacagcacat ctggaggatc ttcaaatgac aacgcctact tcggctacag     4980

caccccctgg gggtattttg acttcaacag attccactgc cacttctcac cacgtgactg     5040

gcagcgactc atcaacaaca actggggatt ccggcctaag cgactcaact tcaagctctt     5100

taacattcag gtcaaagagg ttacggacaa caatggagtc aagaccatcg ccaataacct     5160

taccagcacg gtccaggtct tcacggactc agactatcag ctcccgtacg tgctcgggtc     5220

ggctcacgag ggctgcctcc cgccgttccc agcggacgtt ttcatgattc ctcagtacgg     5280

gtatctgacg cttaatgatg gaagccaggc cgtgggtcgt tcgtcctttt actgcctgga     5340

atatttcccg tcgcaaatgc taagaacggg taacaacttc cagttcagct acgagtttga     5400

gaacgtacct ttccatagca gctacgctca cagccaaagc ctggaccgac taatgaatcc     5460

actcatcgac caatacttgt actatctctc tagaactatt aacggttctg gacagaatca     5520

acaaacgcta aaattcagtg tggccggacc cagcaacatg gctgtccagg gaagaaacta     5580

catacctgga cccagctacc gacaacaacg tgtctcaacc actgtgactc aaaacaacaa     5640

cagcgaattt gcttggcctg gagcttcttc ttgggctctc aatggacgta atagcttgat     5700

gaatcctgga cctgctatgg cctctcacaa agaaggagag gaccgtttct ttcctttgtc     5760

tggatcttta atttttggca aacaaggtac tggcagagac aacgtggatg cggacaaagt     5820

catgataacc aacgaagaag aaattaaaac tactaacccg gtagcaacgg agtcctatgg     5880

acaagtggcc acaaaccacc agagtgccca aactttggcg gtgcctttta aggcacaggc     5940

gcagaccggt tgggttcaaa accaaggaat acttccgggt atggtttggc aggacagaga     6000

tgtgtacctg caaggaccca tttgggccaa aattcctcac acggacggca actttcaccc     6060

ttctccgctg atgggagggt ttggaatgaa gcacccgcct cctcagatcc tcatcaaaaa     6120

cacacctgta cctgcggatc ctccaacggc cttcaacaag gacaagctga actctttcat     6180

cacccagtat tctactggtc aagtcagcgt ggagatcgag tgggagctgc agaaggaaaa     6240

cagcaagcgc tggaacccgg agatccagta cacttccaac tattacaagt ctaataatgt     6300

tgaatttgct gttaatactg aaggtgtata tagtgaaccc cgccccattg gcaccagata     6360

cctgactcgt aatctgtaag tcgacttgct tgttaatcaa taaaccgttt aattcgtttc     6420

agttgaactt tggtctctgc gaagggcaat tcgtttaaac ctgcaggact agaggtcctg     6480

tattagaggt cacgtgagtg ttttgcgaca ttttgcgaca ccatgtggtc acgctgggta     6540

tttaagcccg agtgagcacg cagggtctcc attttgaagc gggaggtttg aacgcgcagc     6600

cgccaagccg aattctgcag atatcacatg tcctaggaac tatcgatcca tcacactggc     6660

ggccgctcga ctagagcggc cgccaccgcg gtggagctcc agcttttgcg gaccgaatcg     6720

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     6780

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     6840

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     6900

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     6960

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     7020

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     7080

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     7140

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     7200

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc     7260

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     7320

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     7380

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     7440

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     7500

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     7560

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     7620

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     7680

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     7740

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     7800

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     7860

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc     7920

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg     7980

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag     8040

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt     8100

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt     8160

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac     8220

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac     8280

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag     8340

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa     8400

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga     8460

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc     8520

cccgaaaagt gccacctgac gtc                                             8543


<210> 2
<211> 1242
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
tgcaagaacc ctcactggct gaactatctt gccagcccct tattttgttt tcatattaac       60

ctcttttttc tagtaaagga gatgtttgct ctcaaatttg cataggaatg taatatttaa      120

tttaaaaaga tgacccacat atgaccttat aaggacagta aaattaaaca accggaaaga      180

taaagcgggc cagttggctc agttctataa aaccagccca caaggattgt cactattctt      240

aggcttgcgc gggctacatg atgagttcca ggactgcctg gttacagacc gagactctct      300

caagagtcca gataaacaac aacaaagggg gcgaggtgga aatacagggg ctgtaagaag      360

taaatatgat atctgcatgg gaggctagcc agagaagaaa aaattttctt ccgtggttca      420

atcctccaag ggctgaacag gaagttgacg caggcaggtg aggagcacga gcctagatgg      480

gctgcggtgc cacccttaat ccccacaagc gagttcctcc gcaattcgcc tgtcccactc      540

tcaacttttc ttcaactgac tctttgctgt ggtccctcgc tgtggcagtg gaaacaacta      600

ccactgcgag gtagggaatg tcatgagggg ctacctgcag cccttggctt gcagggatgc      660

agggatgcgg tcggaacctg aggccccgcc cttctcttgc cccacgccat taggccacgc      720

ccctacccag cactccttca accaccccct tccccggcgc ctcatgaggt cccgcccctc      780

tcaaccctag ctcttgaggc ctccccttca cagccgcccc ggcgttcctt gacttgaggc      840

cacgtccctc tgctccttca ttcccaagac cctacgcttt gcgagtcctc cctgtcctgc      900

tgcctaggac cccgcccctc tcagcccttc tgccccaaga ccccgcccct taggctgttc      960

ccgcccactg gccaatgaag acccgccctt tctttagccg ccccgccccg gtcccacaaa     1020

atcccgcctc cggccccgcc tcccgccccc ttgggcgctc cgtagcagtg acgtgcgcag     1080

gctgggcact ctgcagggct ctctggccgg cgggtggaga ccgatccggg atctgtccca     1140

gcaggaagcg tatcccggcc gccgtcgtgc tgtcgtctcc ggtgctcgct ctcggccgcg     1200

gtgtcgcgct tgcccttcgc gcccgcagcc cggcagcctc tc                        1242


<210> 3
<211> 3221
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
agacacccca gttatggggg ctagggaccc aaaagagaca tccttctgcc acccagagct       60

gccctggcga ggtgcactat ggggccgccg acagctgcgt ggctgccgag ggcggaaagg      120

agaaactgtc atgtcccgat agggccgcgc gaggtctcca tcctcgacaa cgctaataac      180

aaagacgtgt gctcctcttt gcttggttcc ccccactcct ttaaatcaca gatttcactt      240

cagtttatct gtgtcgctgt cacacgtggg gtggctccca gtcagctggt ttggcaaagt      300

ttctggatga ttacggaata acatgtgtcc ccaacccgca gagcaggttg tgggggcaat      360

gttgcattga ccagcgtcag agaacacaca tcagaggcaa gggtgggtgt gcaggaggga      420

gaaggcgcag aaggcagggc tttagctcag cactctccct cctgccatgc tctgcctgac      480

cgttccctct ctgagtccca aacagccagg tagaggagga agaaatgggg ctgagacccc      540

agcacatcag tgattaagtc aggatcaggt gcggtttcct gctcaggtgc tgagacagca      600

ggcggtgtcc tgcaaacaac aggaggcacc tgaagctagc ctggggggcc cacgcccagg      660

tgcggtgcat tcagcagcac agccagagac agaccccaat gaccccgcct ccctgtcggc      720

agccagtgct ctgcacagag ccctgagcag cctctggaca ttagtcccag ccccagcacg      780

gcccgtcccc cacgctgatg tcaccgcacc cagaccttgg aggccccctc cggctccgcc      840

tcctgggaga aggctctgga gtgaggaggg gagggcagca gtgctggctg gacagctgct      900

ctgggcagga gagagaggga gagacaagag acacacacag agagacggcg aggaagggaa      960

agacccagag ggacgcctag aacgagactt ggagccagac agaggaagag gggacgtgtg     1020

tttgcagact ggctgggccc gtgacccagc ttcctgagtc ctccgtgcag gtggcagctg     1080

taccaggctg gcaggtcact gagagtgggc agctgggccc caggtaagga tgggctgccc     1140

actgtcctgg gcattgggag gggtttggat gtggaggagt catggacttg agctacctct     1200

agagcctctg ccccacagcc acttgctcct gggactgggc ttcctgccac ccttgagggc     1260

tcagccacca cagccactga atgaaactgt cccgagcctg ggaagatgga tgtgtgtccc     1320

ctggaggagg gaagagccaa ggagcatgtt gtccatcgaa tcttctctga gctggggctg     1380

gggttagtgg catcctgggg ccaggggaat agacatgctg tggtggcaga gagaagagtc     1440

cgttctctct gtctcctttg ctttctctct gacactcttt atctccgttt ttggataagt     1500

cacttccttc ctctatgccc caaatatccc atctgtgaaa tgggagtatg aagccccaac     1560

agccagggtt gtagtgggga agaggtaaaa tcaggtatag acatagaaat acaaatacag     1620

tctatgcccc ctgttgtcag ttggaaaaga aattaacttg aaggtggtct agttctcatt     1680

tttagaaatg aaatgtctgt ctggtcattt taaaatgtgg cccttaaatt tcacgccctc     1740

accgctctcc cccatccctt ggagccccat gtctctagtg aaagcactgg ctctgccccc     1800

agccctcatg gctcatgctg gcatagggcg cctgctccac agcctgggca ccatcttcag     1860

acaagtgccc ggtggcaact gcctgctggc cctgttgaat ccacatctcc accaggcatc     1920

cagactagtt caggtctctg gaaggaccgt gggtttgctg tgtcccagag ctccagggca     1980

ggggtcaggg ctcggatgtc gggcagtgtc atgggcagag gatcgaatgc cccggcggct     2040

ctgaatgggc ccttgtgaaa aattgatgcg cattctagga gacaggttgg gagccagagg     2100

ggcctcatac cagggtctgt aggctggggc tgccttttaa gctccttcct gaggccgtct     2160

ctgggtctgg ccctgtgctg gacaaggctg gagacaaggc aatgtctcag accctctccc     2220

attggccaca tcctgccctg gatcaactcg ccaactttgg gggcagaggt gggactgacc     2280

cttaccctga caacataatg catatagtca aaatgggata aaggggaata tagaggctct     2340

tggcagcttg ggagtggtca gggaaggctt cctggaggag gtatcatctg aactgagcca     2400

tgaaccataa gtggaaattc actagtcaaa atttcaggta gaagggccag tgtgtgaagg     2460

ccaggagatg gcaagagctg gcgtatttca ggaacagtga gtcactgagg atgtccaagt     2520

ataagggtag gaaagggagt gagcagtgag agaaaagacc gaggcatcag caggggccag     2580

attgtgctgg gcctagcggg gcgggcccgg gcccgggccc aggcccaggt gcggtgcatt     2640

cagcagcaca gccagagaca gaccccaatg accctgcctc cccgtcagca gccagtgctc     2700

tgcacagagc catcctgagg gcagtgggtg ctcttgagag gtttcaggca gggtgtgctg     2760

tgagcaggtc atgcccagcc cttgaccttc tgctcagtca ggcttgtcct tgtcacccac     2820

attcctgggg cagtccctaa gctgagtgcc ggagattaag tcctagtcct aaatttgctc     2880

tggctagctg tgtgaccctg ggcaagtctt ggtccctctc tgggcccctt tgccgtaggt     2940

ccctggtggg gccagacttg ctactttcta ggagcccttt gggaatctct gaatgacagt     3000

ggctgagaga agaattcagc tgctctgggc agtggtgctg gtgacagtgg ctgaggctca     3060

ggtcacacag gctgggcagt ggtcagaggg agagaagcca aggagggttc ccttgaggga     3120

ggaggagctg gggctttggg aggagcccag gtgaccccag ccaggctcaa ggcttccagg     3180

gctggcctgc ccagaagcat gacatggtct ctctccctgc a                         3221


<210> 4
<211> 760
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Pro Lys Lys Val Gln Ile Lys Val Glu Glu Lys Glu Asp Glu 
1               5                   10                  15      


Thr Glu Glu Ser Ser Ser Glu Glu Glu Glu Glu Val Glu Asp Lys Leu 
            20                  25                  30          


Pro Arg Arg Glu Ser Leu Arg Pro Lys Arg Lys Arg Thr Arg Asp Val 
        35                  40                  45              


Ile Asn Glu Asp Asp Pro Glu Pro Glu Pro Glu Asp Glu Glu Thr Arg 
    50                  55                  60                  


Lys Ala Arg Glu Lys Glu Arg Arg Arg Arg Leu Lys Arg Gly Ala Glu 
65                  70                  75                  80  


Glu Glu Glu Ile Asp Glu Glu Glu Leu Glu Arg Leu Lys Ala Glu Leu 
                85                  90                  95      


Asp Glu Lys Arg Gln Ile Ile Ala Thr Val Lys Cys Lys Pro Trp Lys 
            100                 105                 110         


Met Glu Lys Lys Ile Glu Val Leu Lys Glu Ala Lys Lys Phe Val Ser 
        115                 120                 125             


Glu Asn Glu Gly Ala Leu Gly Lys Gly Lys Gly Lys Arg Trp Phe Ala 
    130                 135                 140                 


Phe Lys Met Met Met Ala Lys Lys Trp Ala Lys Phe Leu Arg Asp Phe 
145                 150                 155                 160 


Glu Asn Phe Lys Ala Ala Cys Val Pro Trp Glu Asn Lys Ile Lys Ala 
                165                 170                 175     


Ile Glu Ser Gln Phe Gly Ser Ser Val Ala Ser Tyr Phe Leu Phe Leu 
            180                 185                 190         


Arg Trp Met Tyr Gly Val Asn Met Val Leu Phe Ile Leu Thr Phe Ser 
        195                 200                 205             


Leu Ile Met Leu Pro Glu Tyr Leu Trp Gly Leu Pro Tyr Gly Ser Leu 
    210                 215                 220                 


Pro Arg Lys Thr Val Pro Arg Ala Glu Glu Ala Ser Ala Ala Asn Phe 
225                 230                 235                 240 


Gly Val Leu Tyr Asp Phe Asn Gly Leu Ala Gln Tyr Ser Val Leu Phe 
                245                 250                 255     


Tyr Gly Tyr Tyr Asp Asn Lys Arg Thr Ile Gly Trp Met Asn Phe Arg 
            260                 265                 270         


Leu Pro Leu Ser Tyr Phe Leu Val Gly Ile Met Cys Ile Gly Tyr Ser 
        275                 280                 285             


Phe Leu Val Val Leu Lys Ala Met Thr Lys Asn Ile Gly Asp Asp Gly 
    290                 295                 300                 


Gly Gly Asp Asp Asn Thr Phe Asn Phe Ser Trp Lys Val Phe Thr Ser 
305                 310                 315                 320 


Trp Asp Tyr Leu Ile Gly Asn Pro Glu Thr Ala Asp Asn Lys Phe Asn 
                325                 330                 335     


Ser Ile Thr Met Asn Phe Lys Glu Ala Ile Thr Glu Glu Lys Ala Ala 
            340                 345                 350         


Gln Val Glu Glu Asn Val His Leu Ile Arg Phe Leu Arg Phe Leu Ala 
        355                 360                 365             


Asn Phe Phe Val Phe Leu Thr Leu Gly Gly Ser Gly Tyr Leu Ile Phe 
    370                 375                 380                 


Trp Ala Val Lys Arg Ser Gln Glu Phe Ala Gln Gln Asp Pro Asp Thr 
385                 390                 395                 400 


Leu Gly Trp Trp Glu Lys Asn Glu Met Asn Met Val Met Ser Leu Leu 
                405                 410                 415     


Gly Met Phe Cys Pro Thr Leu Phe Asp Leu Phe Ala Glu Leu Glu Asp 
            420                 425                 430         


Tyr His Pro Leu Ile Ala Leu Lys Trp Leu Leu Gly Arg Ile Phe Ala 
        435                 440                 445             


Leu Leu Leu Gly Asn Leu Tyr Val Phe Ile Leu Ala Leu Met Asp Glu 
    450                 455                 460                 


Ile Asn Asn Lys Ile Glu Glu Glu Lys Leu Val Lys Ala Asn Ile Thr 
465                 470                 475                 480 


Leu Trp Glu Ala Asn Met Ile Lys Ala Tyr Asn Ala Ser Phe Ser Glu 
                485                 490                 495     


Asn Ser Thr Gly Pro Pro Phe Phe Val His Pro Ala Asp Val Pro Arg 
            500                 505                 510         


Gly Pro Cys Trp Glu Thr Met Val Gly Gln Glu Phe Val Arg Leu Thr 
        515                 520                 525             


Val Ser Asp Val Leu Thr Thr Tyr Val Thr Ile Leu Ile Gly Asp Phe 
    530                 535                 540                 


Leu Arg Ala Cys Phe Val Arg Phe Cys Asn Tyr Cys Trp Cys Trp Asp 
545                 550                 555                 560 


Leu Glu Tyr Gly Tyr Pro Ser Tyr Thr Glu Phe Asp Ile Ser Gly Asn 
                565                 570                 575     


Val Leu Ala Leu Ile Phe Asn Gln Gly Met Ile Trp Met Gly Ser Phe 
            580                 585                 590         


Phe Ala Pro Ser Leu Pro Gly Ile Asn Ile Leu Arg Leu His Thr Ser 
        595                 600                 605             


Met Tyr Phe Gln Cys Trp Ala Val Met Cys Cys Asn Val Pro Glu Ala 
    610                 615                 620                 


Arg Val Phe Lys Ala Ser Arg Ser Asn Asn Phe Tyr Leu Gly Met Leu 
625                 630                 635                 640 


Leu Leu Ile Leu Phe Leu Ser Thr Met Pro Val Leu Tyr Met Ile Val 
                645                 650                 655     


Ser Leu Pro Pro Ser Phe Asp Cys Gly Pro Phe Ser Gly Lys Asn Arg 
            660                 665                 670         


Met Phe Glu Val Ile Gly Glu Thr Leu Glu His Asp Phe Pro Ser Trp 
        675                 680                 685             


Met Ala Lys Ile Leu Arg Gln Leu Ser Asn Pro Gly Leu Val Ile Ala 
    690                 695                 700                 


Val Ile Leu Val Met Val Leu Ala Ile Tyr Tyr Leu Asn Ala Thr Ala 
705                 710                 715                 720 


Lys Gly Gln Lys Ala Ala Asn Leu Asp Leu Lys Lys Lys Met Lys Met 
                725                 730                 735     


Gln Ala Leu Glu Asn Lys Met Arg Asn Lys Lys Met Ala Ala Ala Arg 
            740                 745                 750         


Ala Ala Ala Ala Ala Gly Arg Gln 
        755                 760 


<210> 5
<211> 3201
<212> DNA
<213> Homo sapiens

<400> 5
cagaaactat gagggcagaa cccagcaatc tgtgctttct ttcacaagcc ctccaggagt       60

tgctgaaatt taggaatcat tgccccaaaa agtggccctc ataatgatgc cagatgggat      120

cttactctgt tgcccaggct ggagtgcagt ggtgcgatct cggctctctg caacctccgc      180

ctcccaggtt caagtgattc tcctgcctcg gcctcctgag tagctgggat ttcaggccat      240

gaaagatcac tgttttagtc tgcgtggtgc agtggaacag atagacctcg gtttgaatct      300

cagctctact gtttactaga catgaaatgg ggaaatctaa aatgagatgc cagaagcctc      360

aaaaatggaa aaccccctgt gcttcacatc tgaaaatctc tgctgggggc agcaactttg      420

agcctgtggg gaaggaactg tccacgtgga gtggtctggt gaatgcttaa ggagctgcag      480

aagggaagtc cctctccaaa ctagccagcc actgagacct tctgacagga cacccccagg      540

atgtcaccca aaaaagtaca aatcaaagtg gaggaaaaag aagacgagac tgaggaaagc      600

tcaagtgaag aggaagagga ggtggaagat aagctacctc gaagagagag cttgagacca      660

aagaggaaac ggaccagaga tgttatcaat gaggatgacc cagaacctga accagaggat      720

gaagaaacaa ggaaggcaag agaaaaagag aggaggagga ggctaaagag aggagcagaa      780

gaagaagaaa ttgatgaaga ggaattggaa agattgaagg cagagttaga tgagaaaaga      840

caaataattg ctactgtcaa atgcaaacca tggaagatgg agaagaaaat tgaagttctc      900

aaggaggcaa aaaaatttgt gagtgaaaat gaaggggctc ttgggaaagg aaaaggaaaa      960

cggtggtttg catttaagat gatgatggcc aagaaatggg caaaattcct ccgtgatttt     1020

gagaacttca aagctgcgtg tgtcccatgg gaaaataaaa tcaaggctat tgaaagtcag     1080

tttggctcct cagtggcctc atacttcctc ttcttgagat ggatgtatgg agtcaatatg     1140

gttctcttta tcctgacatt tagcctcatc atgttgccag agtacctctg gggtttgcca     1200

tatggcagtt tacctaggaa aaccgttccc agagccgaag aggcatcggc agcaaacttt     1260

ggtgtgttgt acgacttcaa tggtttggca caatattccg ttctctttta tggctattat     1320

gacaataaac gaacaattgg atggatgaat ttcaggttgc cgctctccta ttttctagtg     1380

gggattatgt gcattggata cagctttctg gttgtcctca aagcaatgac caaaaacatt     1440

ggtgatgatg gaggtggaga tgacaacact ttcaatttca gctggaaggt ctttaccagc     1500

tgggactacc tgatcggcaa tcctgaaaca gcagacaaca aatttaattc tatcacaatg     1560

aactttaagg aagctatcac agaagaaaaa gcagcccaag tagaagaaaa cgtccacttg     1620

atcagattcc tgaggtttct ggctaacttc ttcgtgtttc taacacttgg agggagtgga     1680

tacctcatct tttgggctgt gaagcgatcc caggaatttg cacagcaaga tcctgacacc     1740

cttgggtggt gggaaaaaaa tgaaatgaac atggttatgt ccctcctagg gatgttctgt     1800

ccaacattgt ttgacttatt tgctgaatta gaagactacc atcctctcat cgctttgaaa     1860

tggctactgg gacgcatttt tgctcttctt ttaggcaatt tatacgtatt tattcttgca     1920

ttaatggatg agattaacaa caagattgaa gaggagaagc tagtaaaggc caatattacc     1980

ctttgggaag ccaatatgat caaggcctac aatgcatcat tctctgaaaa tagcactgga     2040

ccaccctttt ttgttcaccc tgcagatgta cctcgaggac cttgctggga aacaatggtg     2100

ggacaggagt ttgtgaggct gacagtctct gatgttctga ccacctacgt cacaatcctc     2160

attggggact ttctaagggc atgttttgtg aggttttgca attattgctg gtgctgggac     2220

ttggagtatg gatatccttc atacaccgaa ttcgacatca gtggcaacgt cctcgctctg     2280

atcttcaacc aaggcatgat ctggatgggc tccttctttg ctcccagcct cccaggcatc     2340

aatatccttc gactccatac atccatgtac ttccagtgct gggccgttat gtgctgcaat     2400

gttcctgagg ccagggtctt caaagcttcc agatcaaata acttctacct gggcatgcta     2460

ctgctcatcc tcttcctgtc cacaatgcct gtcttgtaca tgatcgtgtc cctcccacca     2520

tcttttgatt gtggtccatt cagtggcaaa aatagaatgt ttgaagtcat tggagagacc     2580

ctggagcacg atttcccaag ctggatggcg aagatcttga gacagctttc aaaccctggg     2640

ctggtcattg ctgtcatttt ggtgatggtt ttggccatct attatctcaa tgctactgcc     2700

aagggccaga aggcagcgaa tctggatctc aaaaagaaga tgaaaatgca agctttggag     2760

aacaaaatgc gaaacaagaa aatggcagct gcacgagcag ctgcagctgc tggtcgccag     2820

taataagtat cctgagagcc cagaaaaggt acactttgcc ttgctgttta aaagtaatgc     2880

aatatgtgaa cgcccagaga acaagcactg tggaactgct attttcctgt tctacccttg     2940

atggattttc aaggtcatgc tggccaatta aggcatcatc agtcctacct gagcaacaag     3000

aatctaaact ttattccaag tcagaaactg tttctgcaga gccactctct cccctgctcc     3060

atttcgtgac tttttttttt tttttaacaa attgagttta gaagtgagtg taatccagca     3120

atacagttta ctggtttagt tggtgggtta attaaaaaaa atttgctcat atgaactttc     3180

attttatatg tttcttttgc c                                               3201


<210> 6
<211> 906
<212> PRT
<213> Homo sapiens

<400> 6
Met Ser His Gln Val Lys Gly Leu Lys Glu Glu Ala Arg Gly Gly Val 
1               5                   10                  15      


Lys Gly Arg Val Lys Ser Gly Ser Pro His Thr Gly Asp Arg Leu Gly 
            20                  25                  30          


Arg Arg Ser Ser Ser Lys Arg Ala Leu Lys Ala Glu Gly Thr Pro Gly 
        35                  40                  45              


Arg Arg Gly Ala Gln Arg Ser Gln Lys Glu Arg Ala Gly Gly Ser Pro 
    50                  55                  60                  


Ser Pro Gly Ser Pro Arg Arg Lys Gln Thr Gly Arg Arg Arg His Arg 
65                  70                  75                  80  


Glu Glu Leu Gly Glu Gln Glu Arg Gly Glu Ala Glu Arg Thr Cys Glu 
                85                  90                  95      


Gly Arg Arg Lys Arg Asp Glu Arg Ala Ser Phe Gln Glu Arg Thr Ala 
            100                 105                 110         


Ala Pro Lys Arg Glu Lys Glu Ile Pro Arg Arg Glu Glu Lys Ser Lys 
        115                 120                 125             


Arg Gln Lys Lys Pro Arg Ser Ser Ser Leu Ala Ser Ser Ala Ser Gly 
    130                 135                 140                 


Gly Glu Ser Leu Ser Glu Glu Glu Leu Ala Gln Ile Leu Glu Gln Val 
145                 150                 155                 160 


Glu Glu Lys Lys Lys Leu Ile Ala Thr Met Arg Ser Lys Pro Trp Pro 
                165                 170                 175     


Met Ala Lys Lys Leu Thr Glu Leu Arg Glu Ala Gln Glu Phe Val Glu 
            180                 185                 190         


Lys Tyr Glu Gly Ala Leu Gly Lys Gly Lys Gly Lys Gln Leu Tyr Ala 
        195                 200                 205             


Tyr Lys Met Leu Met Ala Lys Lys Trp Val Lys Phe Lys Arg Asp Phe 
    210                 215                 220                 


Asp Asn Phe Lys Thr Gln Cys Ile Pro Trp Glu Met Lys Ile Lys Asp 
225                 230                 235                 240 


Ile Glu Ser His Phe Gly Ser Ser Val Ala Ser Tyr Phe Ile Phe Leu 
                245                 250                 255     


Arg Trp Met Tyr Gly Val Asn Leu Val Leu Phe Gly Leu Ile Phe Gly 
            260                 265                 270         


Leu Val Ile Ile Pro Glu Val Leu Met Gly Met Pro Tyr Gly Ser Ile 
        275                 280                 285             


Pro Arg Lys Thr Val Pro Arg Ala Glu Glu Glu Lys Ala Met Asp Phe 
    290                 295                 300                 


Ser Val Leu Trp Asp Phe Glu Gly Tyr Ile Lys Tyr Ser Ala Leu Phe 
305                 310                 315                 320 


Tyr Gly Tyr Tyr Asn Asn Gln Arg Thr Ile Gly Trp Leu Arg Tyr Arg 
                325                 330                 335     


Leu Pro Met Ala Tyr Phe Met Val Gly Val Ser Val Phe Gly Tyr Ser 
            340                 345                 350         


Leu Ile Ile Val Ile Arg Ser Met Ala Ser Asn Thr Gln Gly Ser Thr 
        355                 360                 365             


Gly Glu Gly Glu Ser Asp Asn Phe Thr Phe Ser Phe Lys Met Phe Thr 
    370                 375                 380                 


Ser Trp Asp Tyr Leu Ile Gly Asn Ser Glu Thr Ala Asp Asn Lys Tyr 
385                 390                 395                 400 


Ala Ser Ile Thr Thr Ser Phe Lys Glu Ser Ile Val Asp Glu Gln Glu 
                405                 410                 415     


Ser Asn Lys Glu Glu Asn Ile His Leu Thr Arg Phe Leu Arg Val Leu 
            420                 425                 430         


Ala Asn Phe Leu Ile Ile Cys Cys Leu Cys Gly Ser Gly Tyr Leu Ile 
        435                 440                 445             


Tyr Phe Val Val Lys Arg Ser Gln Gln Phe Ser Lys Met Gln Asn Val 
    450                 455                 460                 


Ser Trp Tyr Glu Arg Asn Glu Val Glu Ile Val Met Ser Leu Leu Gly 
465                 470                 475                 480 


Met Phe Cys Pro Pro Leu Phe Glu Thr Ile Ala Ala Leu Glu Asn Tyr 
                485                 490                 495     


His Pro Arg Thr Gly Leu Lys Trp Gln Leu Gly Arg Ile Phe Ala Leu 
            500                 505                 510         


Phe Leu Gly Asn Leu Tyr Thr Phe Leu Leu Ala Leu Met Asp Asp Val 
        515                 520                 525             


His Leu Lys Leu Ala Asn Glu Glu Thr Ile Lys Asn Ile Thr His Trp 
    530                 535                 540                 


Thr Leu Phe Asn Tyr Tyr Asn Ser Ser Gly Trp Asn Glu Ser Val Pro 
545                 550                 555                 560 


Arg Pro Pro Leu His Pro Ala Asp Val Pro Arg Gly Ser Cys Trp Glu 
                565                 570                 575     


Thr Ala Val Gly Ile Glu Phe Met Arg Leu Thr Val Ser Asp Met Leu 
            580                 585                 590         


Val Thr Tyr Ile Thr Ile Leu Leu Gly Asp Phe Leu Arg Ala Cys Phe 
        595                 600                 605             


Val Arg Phe Met Asn Tyr Cys Trp Cys Trp Asp Leu Glu Ala Gly Phe 
    610                 615                 620                 


Pro Ser Tyr Ala Glu Phe Asp Ile Ser Gly Asn Val Leu Gly Leu Ile 
625                 630                 635                 640 


Phe Asn Gln Gly Met Ile Trp Met Gly Ser Phe Tyr Ala Pro Gly Leu 
                645                 650                 655     


Val Gly Ile Asn Val Leu Arg Leu Leu Thr Ser Met Tyr Phe Gln Cys 
            660                 665                 670         


Trp Ala Val Met Ser Ser Asn Val Pro His Glu Arg Val Phe Lys Ala 
        675                 680                 685             


Ser Arg Ser Asn Asn Phe Tyr Met Gly Leu Leu Leu Leu Val Leu Phe 
    690                 695                 700                 


Leu Ser Leu Leu Pro Val Ala Tyr Thr Ile Met Ser Leu Pro Pro Ser 
705                 710                 715                 720 


Phe Asp Cys Gly Pro Phe Ser Gly Lys Asn Arg Met Tyr Asp Val Leu 
                725                 730                 735     


Gln Glu Thr Ile Glu Asn Asp Phe Pro Thr Phe Leu Gly Lys Ile Phe 
            740                 745                 750         


Ala Phe Leu Ala Asn Pro Gly Leu Ile Ile Pro Ala Ile Leu Leu Met 
        755                 760                 765             


Phe Leu Ala Ile Tyr Tyr Leu Asn Ser Val Ser Lys Ser Leu Ser Arg 
    770                 775                 780                 


Ala Asn Ala Gln Leu Arg Lys Lys Ile Gln Val Leu Arg Glu Val Glu 
785                 790                 795                 800 


Lys Ser His Lys Ser Val Lys Gly Lys Ala Thr Ala Arg Asp Ser Glu 
                805                 810                 815     


Asp Thr Pro Lys Ser Ser Ser Lys Asn Ala Thr Gln Leu Gln Leu Thr 
            820                 825                 830         


Lys Glu Glu Thr Thr Pro Pro Ser Ala Ser Gln Ser Gln Ala Met Asp 
        835                 840                 845             


Lys Lys Ala Gln Gly Pro Gly Thr Ser Asn Ser Ala Ser Arg Thr Thr 
    850                 855                 860                 


Leu Pro Ala Ser Gly His Leu Pro Ile Ser Arg Pro Pro Gly Ile Gly 
865                 870                 875                 880 


Pro Asp Ser Gly His Ala Pro Ser Gln Thr His Pro Trp Arg Ser Ala 
                885                 890                 895     


Ser Gly Lys Ser Ala Gln Arg Pro Pro His 
            900                 905     


<210> 7
<211> 3169
<212> DNA
<213> Homo sapiens

<400> 7
gcagtgctgc tgaccatgag ccaccaggta aagggcctga aagaggaagc acgaggcgga       60

gtgaaagggc gggtgaagag cggctctcca cacacaggtg acaggctggg aaggagatcc      120

tcaagcaagc gggctctcaa agccgagggg accccaggca ggcgcggagc tcagcgaagc      180

cagaaggagc gcgccggggg cagcccaagc ccggggtctc cccggaggaa gcaaacaggg      240

cgcaggagac acagagaaga gctgggggag caggagcggg gcgaggcaga gaggacctgc      300

gagggcagga gaaagcgcga cgagagggcc tccttccagg agcggacagc agccccaaag      360

agggaaaagg agattccgag gagggaggag aagtcgaagc ggcagaagaa acccaggtca      420

tcctccttgg cctccagtgc ctctggtggg gagtccctgt ccgaggagga actggcccag      480

atcctggagc aggtggaaga aaaaaagaag ctcattgcca ccatgcggag caagccctgg      540

cccatggcga agaagctgac agagctcagg gaggcccagg aatttgtgga gaagtatgaa      600

ggtgccttgg gaaaggggaa aggcaagcaa ctatatgcct acaagatgct gatggccaag      660

aaatgggtca aatttaagag agactttgat aatttcaaga ctcaatgtat cccctgggaa      720

atgaagatca aggacattga aagtcacttt ggttcttcag tggcatcgta tttcatcttt      780

ctccgatgga tgtatggagt taaccttgtc ctttttggct taatatttgg tctagtcata      840

atcccagagg tactgatggg catgccctat gggagtattc ccagaaagac agtgcctcgg      900

gctgaggaag aaaaggccat ggatttttct gtcctttggg attttgaggg ctatatcaag      960

tactctgcac tcttctatgg ctactacaac aaccagagga ccatcgggtg gctgaggtac     1020

cggctgccta tggcttactt tatggtgggg gtcagcgtgt tcggctacag cctgattatt     1080

gtcattcgat cgatggccag caatacccaa ggaagcacag gcgaagggga gagtgacaac     1140

ttcacattca gcttcaagat gttcaccagc tgggactacc tgatcgggaa ttcagagaca     1200

gctgataaca aatatgcatc catcaccacc agcttcaagg aatcaatagt ggatgaacaa     1260

gagagtaaca aagaagaaaa tatccatctg acaagatttc ttcgtgtcct ggccaacttt     1320

ctcatcatct gctgtttgtg tggaagtggg tacctcattt actttgtggt taagcgatct     1380

cagcaattct ccaaaatgca gaatgtcagc tggtatgaaa ggaatgaggt agagatcgtg     1440

atgtccctgc ttggaatgtt ttgtccccct ctgtttgaaa ccatcgctgc cctggagaat     1500

taccacccac gcactggact gaagtggcag ctgggacgca tctttgcact cttcctgggg     1560

aacctctaca catttctctt ggccctgatg gatgacgtcc acctcaagct tgctaatgaa     1620

gagacaataa agaacatcac tcactggact ctgtttaact attacaactc ttctggttgg     1680

aacgagagtg tcccccgacc acccctgcac cctgcagatg tgccccgggg ttcttgctgg     1740

gagacagctg tgggcattga attcatgagg ctgacggtgt ctgacatgct ggtaacgtac     1800

atcaccatcc tgctggggga cttcctacgg gcttgttttg tgcggttcat gaactactgc     1860

tggtgctggg acttggaggc tggatttcct tcatatgctg agtttgatat tagtggaaat     1920

gtgctgggtt tgatcttcaa ccaaggaatg atctggatgg gctccttcta tgctccaggc     1980

ctggtgggca ttaatgtgct gcgcctgctg acctccatgt acttccagtg ctgggcggtg     2040

atgagcagca acgtacccca tgaacgcgtg ttcaaagcct cccgatccaa caacttctac     2100

atgggcctcc tgctgctggt gctcttcctc agcctcctgc cggtggccta caccatcatg     2160

tccctcccac cctcctttga ctgcgggccg ttcagtggga aaaacagaat gtacgatgtc     2220

ctccaagaga ccattgaaaa cgatttccca accttcctgg gcaagatctt tgctttcctc     2280

gccaatccag gcctgatcat cccagccatc ctgctgatgt tcttggccat ttactacctg     2340

aactcagttt ccaaaagcct ttcccgagct aatgcccagc tgaggaagaa aatccaagtg     2400

ctccgtgaag ttgagaagag tcacaaatct gtaaaaggca aagccacagc cagagattca     2460

gaggacacac ctaaaagcag ctccaaaaat gccacccagc tccaactcac caaggaagag     2520

accactcctc cctctgccag ccaaagccag gccatggaca agaaggcgca gggccctggg     2580

acctccaatt ctgccagcag gaccacactg cctgcctctg gacaccttcc tatatctcgg     2640

ccccctggaa tcggaccaga ttctggccac gccccatctc agactcatcc gtggaggtca     2700

gcctctggaa agagtgctca gagacctccc cactgatggc taggactcca gggagcctcg     2760

accctagggc tgatcctcaa gtaccccagt ttcacacata ccaaaccaag gttctctccc     2820

ctctttcctc tcacatacat gctctgtctc ctctcttgga atgcatgaac tttgattcct     2880

tcaggccctt gtcagctacc gaaggaggaa gacagtggct tcacctgtcc tttagggaag     2940

ctggagccat ctctgcacta actgccctcc caaatatctt ggttcagaca gctctgaacc     3000

ccacgctcac agtggtcgac cttgcctccc gattttcgga gttggggaag ggccatgacc     3060

accctcgtag actttttcca tgggatacag tttaggacac gggtttctgc cagcttccct     3120

aaccaggagg gggatggaga agggcctaca tttctcaatc cagaggaag                 3169


<210> 8
<211> 552
<212> PRT
<213> Homo sapiens

<400> 8
Met Asp Arg Lys Val Ala Arg Glu Phe Arg His Lys Val Asp Phe Leu 
1               5                   10                  15      


Ile Glu Asn Asp Ala Glu Lys Asp Tyr Leu Tyr Asp Val Leu Arg Met 
            20                  25                  30          


Tyr His Gln Thr Met Asp Val Ala Val Leu Val Gly Asp Leu Lys Leu 
        35                  40                  45              


Val Ile Asn Glu Pro Ser Arg Leu Pro Leu Phe Asp Ala Ile Arg Pro 
    50                  55                  60                  


Leu Ile Pro Leu Lys His Gln Val Glu Tyr Asp Gln Leu Thr Pro Arg 
65                  70                  75                  80  


Arg Ser Arg Lys Leu Lys Glu Val Arg Leu Asp Arg Leu His Pro Glu 
                85                  90                  95      


Gly Leu Gly Leu Ser Val Arg Gly Gly Leu Glu Phe Gly Cys Gly Leu 
            100                 105                 110         


Phe Ile Ser His Leu Ile Lys Gly Gly Gln Ala Asp Ser Val Gly Leu 
        115                 120                 125             


Gln Val Gly Asp Glu Ile Val Arg Ile Asn Gly Tyr Ser Ile Ser Ser 
    130                 135                 140                 


Cys Thr His Glu Glu Val Ile Asn Leu Ile Arg Thr Lys Lys Thr Val 
145                 150                 155                 160 


Ser Ile Lys Val Arg His Ile Gly Leu Ile Pro Val Lys Ser Ser Pro 
                165                 170                 175     


Asp Glu Pro Leu Thr Trp Gln Tyr Val Asp Gln Phe Val Ser Glu Ser 
            180                 185                 190         


Gly Gly Val Arg Gly Ser Leu Gly Ser Pro Gly Asn Arg Glu Asn Lys 
        195                 200                 205             


Glu Lys Lys Val Phe Ile Ser Leu Val Gly Ser Arg Gly Leu Gly Cys 
    210                 215                 220                 


Ser Ile Ser Ser Gly Pro Ile Gln Lys Pro Gly Ile Phe Ile Ser His 
225                 230                 235                 240 


Val Lys Pro Gly Ser Leu Ser Ala Glu Val Gly Leu Glu Ile Gly Asp 
                245                 250                 255     


Gln Ile Val Glu Val Asn Gly Val Asp Phe Ser Asn Leu Asp His Lys 
            260                 265                 270         


Glu Ala Val Asn Val Leu Lys Ser Ser Arg Ser Leu Thr Ile Ser Ile 
        275                 280                 285             


Val Ala Ala Ala Gly Arg Glu Leu Phe Met Thr Asp Arg Glu Arg Leu 
    290                 295                 300                 


Ala Glu Ala Arg Gln Arg Glu Leu Gln Arg Gln Glu Leu Leu Met Gln 
305                 310                 315                 320 


Lys Arg Leu Ala Met Glu Ser Asn Lys Ile Leu Gln Glu Gln Gln Glu 
                325                 330                 335     


Met Glu Arg Gln Arg Arg Lys Glu Ile Ala Gln Lys Ala Ala Glu Glu 
            340                 345                 350         


Asn Glu Arg Tyr Arg Lys Glu Met Glu Gln Ile Val Glu Glu Glu Glu 
        355                 360                 365             


Lys Phe Lys Lys Gln Trp Glu Glu Asp Trp Gly Ser Lys Glu Gln Leu 
    370                 375                 380                 


Leu Leu Pro Lys Thr Ile Thr Ala Glu Val His Pro Val Pro Leu Arg 
385                 390                 395                 400 


Lys Pro Lys Tyr Asp Gln Gly Val Glu Pro Glu Leu Glu Pro Ala Asp 
                405                 410                 415     


Asp Leu Asp Gly Gly Thr Glu Glu Gln Gly Glu Gln Asp Phe Arg Lys 
            420                 425                 430         


Tyr Glu Glu Gly Phe Asp Pro Tyr Ser Met Phe Thr Pro Glu Gln Ile 
        435                 440                 445             


Met Gly Lys Asp Val Arg Leu Leu Arg Ile Lys Lys Glu Gly Ser Leu 
    450                 455                 460                 


Asp Leu Ala Leu Glu Gly Gly Val Asp Ser Pro Ile Gly Lys Val Val 
465                 470                 475                 480 


Val Ser Ala Val Tyr Glu Arg Gly Ala Ala Glu Arg His Gly Gly Ile 
                485                 490                 495     


Val Lys Gly Asp Glu Ile Met Ala Ile Asn Gly Lys Ile Val Thr Asp 
            500                 505                 510         


Tyr Thr Leu Ala Glu Ala Glu Ala Ala Leu Gln Lys Ala Trp Asn Gln 
        515                 520                 525             


Gly Gly Asp Trp Ile Asp Leu Val Val Ala Val Cys Pro Pro Lys Glu 
    530                 535                 540                 


Tyr Asp Asp Glu Leu Thr Phe Phe 
545                 550         


<210> 9
<211> 2237
<212> DNA
<213> Homo sapiens

<400> 9
agctccgagg gcggctggcc cggtcgcggt cgcggctctt tccagctcct ggcagccggg       60

cacccgaagg aacgggtcgt gcaacgacgc agctggacct ggcccagcca tggaccgaaa      120

agtggcccga gaattccggc ataaggtgga ttttctgatt gaaaatgatg cagagaagga      180

ctatctctat gatgtgctgc gaatgtacca ccagaccatg gacgtggccg tgctcgtggg      240

agacctgaag ctggtcatca atgaacccag ccgtctgcct ctgtttgatg ccattcggcc      300

gctgatccca ctgaagcacc aggtggaata tgatcagctg accccccggc gctccaggaa      360

gctgaaggag gtgcgtctgg accgtctgca ccccgaaggc ctcggcctga gtgtgcgtgg      420

tggcctggag tttggctgtg ggctcttcat ctcccacctc atcaaaggcg gtcaggcaga      480

cagcgtcggg ctccaggtag gggacgagat cgtccggatc aatggatatt ccatctcctc      540

ctgtacccat gaggaggtca tcaacctcat tcgaaccaag aaaactgtgt ccatcaaagt      600

gagacacatc ggcctgatcc ccgtgaaaag ctctcctgat gagcccctca cttggcagta      660

tgtggatcag tttgtgtcgg aatctggggg cgtgcgaggc agcctgggct cccctggaaa      720

tcgggaaaac aaggagaaga aggtcttcat cagcctggta ggctcccgag gccttggctg      780

cagcatttcc agcggcccca tccagaagcc tggcatcttt atcagccatg tgaaacctgg      840

ctccctgtct gctgaggtgg gattggagat aggggaccag attgtcgaag tcaatggcgt      900

cgacttctct aacctggatc acaaggaggc tgtaaatgtg ctgaagagta gccgcagcct      960

gaccatctcc attgtagctg cagctggccg ggagctgttc atgacagacc gggagcggct     1020

ggcagaggcg cggcagcgtg agctgcagcg gcaggagctt ctcatgcaga agcggctggc     1080

gatggagtcc aacaagatcc tccaggagca gcaggagatg gagcggcaaa ggagaaaaga     1140

aattgcccag aaggcagcag aggaaaatga gagataccgg aaggagatgg aacagattgt     1200

agaggaggaa gagaagttta agaagcaatg ggaagaagac tggggctcaa aggaacagct     1260

actcttgcct aaaaccatca ctgctgaggt acacccagta ccccttcgca agccaaagta     1320

tgatcaggga gtggaacctg agctcgagcc cgcagatgac ctggatggag gcacggagga     1380

gcagggagag caggatttcc ggaaatatga ggaaggcttt gacccctact ctatgttcac     1440

cccagagcag atcatgggga aggatgtccg gctcctacgc atcaagaagg agggatcctt     1500

agacctggcc ctggaaggcg gtgtggactc ccccattggg aaggtggtcg tttctgctgt     1560

gtatgagcgg ggagctgctg agcggcatgg tggcattgtg aaaggggacg agatcatggc     1620

aatcaacggc aagattgtga cagactacac cctggctgag gctgaggctg ccctgcagaa     1680

ggcctggaat cagggcgggg actggatcga ccttgtggtt gccgtctgcc ccccaaagga     1740

gtatgacgat gagctgacct tcttctgaag tccaaaaggg gaaaccaaat tcaccgttag     1800

gaaacagtga gctccggccc cacctcgtga acacaaagcc tcggatcagc cttgagagag     1860

gccacactac acacaccaga tggcatcctt gggacctgaa tctatcaccc aggaatctca     1920

aactcccttt ggccctgaac cagggccaga taaggaacag ctcgggccac tcttctgaag     1980

gccaacgtgg aggaaaggga gcagccagcc atttgggaga agatctcaag gatccagact     2040

ctcattcctt tcctctggcc cagtgaattt ggtctctccc agctctgggg gactccttcc     2100

ttgaacccta ataagacccc actggagtct ctctctctcc atccctctcc tctgccctct     2160

gctctaattg ctgccaggat tgtcactcca aaccttactc tgagctcatt aataaaatag     2220

atttattttc cagctta                                                    2237


<210> 10
<211> 2385
<212> DNA
<213> Homo sapiens

<400> 10
agctccgagg gcggctggcc cggtcgcggt cgcggctctt tccagctcct ggcagccggg       60

cacccgaagg aacgggtcgt gcaacgacgc agctggacct ggcccagcca tggaccgaaa      120

agtggcccga gaattccggc ataaggtgga ttttctgatt gaaaatgatg cagagaagga      180

ctatctctat gatgtgctgc gaatgtacca ccagaccatg gacgtggccg tgctcgtggg      240

agacctgaag ctggtcatca atgaacccag ccgtctgcct ctgtttgatg ccattcggcc      300

gctgatccca ctgaagcacc aggtggaata tgatcagctg accccccggc gctccaggaa      360

gctgaaggag gtgcgtctgg accgtctgca ccccgaaggc ctcggcctga gtgtgcgtgg      420

tggcctggag tttggctgtg ggctcttcat ctcccacctc atcaaaggcg gtcaggcaga      480

cagcgtcggg ctccaggtag gggacgagat cgtccggatc aatggatatt ccatctcctc      540

ctgtacccat gaggaggtca tcaacctcat tcgaaccaag aaaactgtgt ccatcaaagt      600

gagacacatc ggcctgatcc ccgtgaaaag ctctcctgat gagcccctca cttggcagta      660

tgtggatcag tttgtgtcgg aatctggggg cgtgcgaggc agcctgggct cccctggaaa      720

tcgggaaaac aaggagaaga aggtcttcat cagcctggta ggctcccgag gccttggctg      780

cagcatttcc agcggcccca tccagaagcc tggcatcttt atcagccatg tgaaacctgg      840

ctccctgtct gctgaggtgg gattggagat aggggaccag attgtcgaag tcaatggcgt      900

cgacttctct aacctggatc acaaggaggc tgtaaatgtg ctgaagagta gccgcagcct      960

gaccatctcc attgtagctg cagctggccg ggagctgttc atgacagacc gggagcggct     1020

ggcagaggcg cggcagcgtg agctgcagcg gcaggagctt ctcatgcaga agcggctggc     1080

gatggagtcc aacaagatcc tccaggagca gcaggagatg gagcggcaaa ggagaaaaga     1140

aattgcccag aaggcagcag aggaaaatga gagataccgg aaggagatgg aacagattgt     1200

agaggaggaa gagaagttta agaagcaatg ggaagaagac tggggctcaa aggaacagct     1260

actcttgcct aaaaccatca ctgctgaggt acacccagta ccccttcgca agccaaagta     1320

tgatcaggga gtggaacctg agctcgagcc cgcagatgac ctggatggag gcacggagga     1380

gcagggagag cagaaaggaa aagataagaa gaaagccaag tatggcagcc tgcaggactt     1440

gagaaagaat aagaaagaac tggagtttga gcaaaagctt tacaaagaga aagaggaaat     1500

gctggagaag gaaaagcagc taaagatcaa ccggctggcc caggaggatt tccggaaata     1560

tgaggaaggc tttgacccct actctatgtt caccccagag cagatcatgg ggaaggatgt     1620

ccggctccta cgcatcaaga aggagggatc cttagacctg gccctggaag gcggtgtgga     1680

ctcccccatt gggaaggtgg tcgtttctgc tgtgtatgag cggggagctg ctgagcggca     1740

tggtggcatt gtgaaagggg acgagatcat ggcaatcaac ggcaagattg tgacagacta     1800

caccctggct gaggctgagg ctgccctgca gaaggcctgg aatcagggcg gggactggat     1860

cgaccttgtg gttgccgtct gccccccaaa ggagtatgac gatgagctga ccttcttctg     1920

aagtccaaaa ggggaaacca aattcaccgt taggaaacag tgagctccgg ccccacctcg     1980

tgaacacaaa gcctcggatc agccttgaga gaggccacac tacacacacc agatggcatc     2040

cttgggacct gaatctatca cccaggaatc tcaaactccc tttggccctg aaccagggcc     2100

agataaggaa cagctcgggc cactcttctg aaggccaacg tggaggaaag ggagcagcca     2160

gccatttggg agaagatctc aaggatccag actctcattc ctttcctctg gcccagtgaa     2220

tttggtctct cccagctctg ggggactcct tccttgaacc ctaataagac cccactggag     2280

tctctctctc tccatccctc tcctctgccc tctgctctaa ttgctgccag gattgtcact     2340

ccaaacctta ctctgagctc attaataaaa tagatttatt ttcca                     2385


<210> 11
<211> 899
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Arg Lys Val Ala Arg Glu Phe Arg His Lys Val Asp Phe Leu 
1               5                   10                  15      


Ile Glu Asn Asp Ala Glu Lys Asp Tyr Leu Tyr Asp Val Leu Arg Met 
            20                  25                  30          


Tyr His Gln Thr Met Asp Val Ala Val Leu Val Gly Asp Leu Lys Leu 
        35                  40                  45              


Val Ile Asn Glu Pro Ser Arg Leu Pro Leu Phe Asp Ala Ile Arg Pro 
    50                  55                  60                  


Leu Ile Pro Leu Lys His Gln Val Glu Tyr Asp Gln Leu Thr Pro Arg 
65                  70                  75                  80  


Arg Ser Arg Lys Leu Lys Glu Val Arg Leu Asp Arg Leu His Pro Glu 
                85                  90                  95      


Gly Leu Gly Leu Ser Val Arg Gly Gly Leu Glu Phe Gly Cys Gly Leu 
            100                 105                 110         


Phe Ile Ser His Leu Ile Lys Gly Gly Gln Ala Asp Ser Val Gly Leu 
        115                 120                 125             


Gln Val Gly Asp Glu Ile Val Arg Ile Asn Gly Tyr Ser Ile Ser Ser 
    130                 135                 140                 


Cys Thr His Glu Glu Val Ile Asn Leu Ile Arg Thr Lys Lys Thr Val 
145                 150                 155                 160 


Ser Ile Lys Val Arg His Ile Gly Leu Ile Pro Val Lys Ser Ser Pro 
                165                 170                 175     


Asp Glu Pro Leu Thr Trp Gln Tyr Val Asp Gln Phe Val Ser Glu Ser 
            180                 185                 190         


Gly Gly Val Arg Gly Ser Leu Gly Ser Pro Gly Asn Arg Glu Asn Lys 
        195                 200                 205             


Glu Lys Lys Val Phe Ile Ser Leu Val Gly Ser Arg Gly Leu Gly Cys 
    210                 215                 220                 


Ser Ile Ser Ser Gly Pro Ile Gln Lys Pro Gly Ile Phe Ile Ser His 
225                 230                 235                 240 


Val Lys Pro Gly Ser Leu Ser Ala Glu Val Gly Leu Glu Ile Gly Asp 
                245                 250                 255     


Gln Ile Val Glu Val Asn Gly Val Asp Phe Ser Asn Leu Asp His Lys 
            260                 265                 270         


Glu Ala Val Asn Val Leu Lys Ser Ser Arg Ser Leu Thr Ile Ser Ile 
        275                 280                 285             


Val Ala Ala Ala Gly Arg Glu Leu Phe Met Thr Asp Arg Glu Arg Leu 
    290                 295                 300                 


Ala Glu Ala Arg Gln Arg Glu Leu Gln Arg Gln Glu Leu Leu Met Gln 
305                 310                 315                 320 


Lys Arg Leu Ala Met Glu Ser Asn Lys Ile Leu Gln Glu Gln Gln Glu 
                325                 330                 335     


Met Glu Arg Gln Arg Arg Lys Glu Ile Ala Gln Lys Ala Ala Glu Glu 
            340                 345                 350         


Asn Glu Arg Tyr Arg Lys Glu Met Glu Gln Ile Val Glu Glu Glu Glu 
        355                 360                 365             


Lys Phe Lys Lys Gln Trp Glu Glu Asp Trp Gly Ser Lys Glu Gln Leu 
    370                 375                 380                 


Leu Leu Pro Lys Thr Ile Thr Ala Glu Val His Pro Val Pro Leu Arg 
385                 390                 395                 400 


Lys Pro Lys Ser Phe Gly Trp Phe Tyr Arg Tyr Asp Gly Lys Phe Pro 
                405                 410                 415     


Thr Ile Arg Lys Lys Gly Lys Asp Lys Lys Lys Ala Lys Tyr Gly Ser 
            420                 425                 430         


Leu Gln Asp Leu Arg Lys Asn Lys Lys Glu Leu Glu Phe Glu Gln Lys 
        435                 440                 445             


Leu Tyr Lys Glu Lys Glu Glu Met Leu Glu Lys Glu Lys Gln Leu Lys 
    450                 455                 460                 


Ile Asn Arg Leu Ala Gln Glu Val Ser Glu Thr Glu Arg Glu Asp Leu 
465                 470                 475                 480 


Glu Glu Ser Glu Lys Ile Gln Tyr Trp Val Glu Arg Leu Cys Gln Thr 
                485                 490                 495     


Arg Leu Glu Gln Ile Ser Ser Ala Asp Asn Glu Ile Ser Glu Met Thr 
            500                 505                 510         


Thr Gly Pro Pro Pro Pro Pro Pro Ser Val Ser Pro Leu Ala Pro Pro 
        515                 520                 525             


Leu Arg Arg Phe Ala Gly Gly Leu His Leu His Thr Thr Asp Leu Asp 
    530                 535                 540                 


Asp Ile Pro Leu Asp Met Phe Tyr Tyr Pro Pro Lys Thr Pro Ser Ala 
545                 550                 555                 560 


Leu Pro Val Met Pro His Pro Pro Pro Ser Asn Pro Pro His Lys Val 
                565                 570                 575     


Pro Ala Pro Pro Val Leu Pro Leu Ser Gly His Val Ser Ala Ser Ser 
            580                 585                 590         


Ser Pro Trp Val Gln Arg Thr Pro Pro Pro Ile Pro Ile Pro Pro Pro 
        595                 600                 605             


Pro Ser Val Pro Thr Gln Asp Leu Thr Pro Thr Arg Pro Leu Pro Ser 
    610                 615                 620                 


Ala Leu Glu Glu Ala Leu Ser Asn His Pro Phe Arg Thr Gly Asp Thr 
625                 630                 635                 640 


Gly Asn Pro Val Glu Asp Trp Glu Ala Lys Asn His Ser Gly Lys Pro 
                645                 650                 655     


Thr Asn Ser Pro Val Pro Glu Gln Ser Phe Pro Pro Thr Pro Lys Thr 
            660                 665                 670         


Phe Cys Pro Ser Pro Gln Pro Pro Arg Gly Pro Gly Val Ser Thr Ile 
        675                 680                 685             


Ser Lys Pro Val Met Val His Gln Glu Pro Asn Phe Ile Tyr Arg Pro 
    690                 695                 700                 


Ala Val Lys Ser Glu Val Leu Pro Gln Glu Met Leu Lys Arg Met Val 
705                 710                 715                 720 


Val Tyr Gln Thr Ala Phe Arg Gln Asp Phe Arg Lys Tyr Glu Glu Gly 
                725                 730                 735     


Phe Asp Pro Tyr Ser Met Phe Thr Pro Glu Gln Ile Met Gly Lys Asp 
            740                 745                 750         


Val Arg Leu Leu Arg Ile Lys Lys Glu Gly Ser Leu Asp Leu Ala Leu 
        755                 760                 765             


Glu Gly Gly Val Asp Ser Pro Ile Gly Lys Val Val Val Ser Ala Val 
    770                 775                 780                 


Tyr Glu Arg Gly Ala Ala Glu Arg His Gly Gly Ile Val Lys Gly Asp 
785                 790                 795                 800 


Glu Ile Met Ala Ile Asn Gly Lys Ile Val Thr Asp Tyr Thr Leu Ala 
                805                 810                 815     


Glu Ala Glu Ala Ala Leu Gln Lys Ala Trp Asn Gln Gly Gly Asp Trp 
            820                 825                 830         


Ile Asp Leu Val Val Ala Val Cys Pro Pro Lys Glu Tyr Asp Asp Glu 
        835                 840                 845             


Leu Ala Ser Leu Pro Ser Ser Val Ala Glu Ser Pro Gln Pro Val Arg 
    850                 855                 860                 


Lys Leu Leu Glu Asp Arg Ala Ala Val His Arg His Gly Phe Leu Leu 
865                 870                 875                 880 


Gln Leu Glu Pro Thr Asp Leu Leu Leu Lys Ser Lys Arg Gly Asn Gln 
                885                 890                 895     


Ile His Arg 
            


<210> 12
<211> 2180
<212> DNA
<213> Homo sapiens

<400> 12
agctccgagg gcggctggcc cggtcgcggt cgcggctctt tccagctcct ggcagccggg       60

cacccgaagg aacgggtcgt gcaacgacgc agctggacct ggcccagcca tggaccgaaa      120

agtggcccga gaattccggc ataaggtgga ttttctgatt gaaaatgatg cagagaagga      180

ctatctctat gatgtgctgc gaatgtacca ccagaccatg gacgtggccg tgctcgtggg      240

agacctgaag ctggtcatca atgaacccag ccgtctgcct ctgtttgatg ccattcggcc      300

gctgatccca ctgaagcacc aggtggaata tgatcagctg accccccggc gctccaggaa      360

gctgaaggag gtgcgtctgg accgtctgca ccccgaaggc ctcggcctga gtgtgcgtgg      420

tggcctggag tttggctgtg ggctcttcat ctcccacctc atcaaaggcg gtcaggcaga      480

cagcgtcggg ctccaggtag gggacgagat cgtccggatc aatggatatt ccatctcctc      540

ctgtacccat gaggaggtca tcaacctcat tcgaaccaag aaaactgtgt ccatcaaagt      600

gagacacatc ggcctgatcc ccgtgaaaag ctctcctgat gagcccctca cttggcagta      660

tgtggatcag tttgtgtcgg aatctggggg cgtgcgaggc agcctgggct cccctggaaa      720

tcgggaaaac aaggagaaga aggtcttcat cagcctggta ggctcccgag gccttggctg      780

cagcatttcc agcggcccca tccagaagcc tggcatcttt atcagccatg tgaaacctgg      840

ctccctgtct gctgaggtgg gattggagat aggggaccag attgtcgaag tcaatggcgt      900

cgacttctct aacctggatc acaaggaggg ccgggagctg ttcatgacag accgggagcg      960

gctggcagag gcgcggcagc gtgagctgca gcggcaggag cttctcatgc agaagcggct     1020

ggcgatggag tccaacaaga tcctccagga gcagcaggag atggagcggc aaaggagaaa     1080

agaaattgcc cagaaggcag cagaggaaaa tgagagatac cggaaggaga tggaacagat     1140

tgtagaggag gaagagaagt ttaagaagca atgggaagaa gactggggct caaaggaaca     1200

gctactcttg cctaaaacca tcactgctga ggtacaccca gtaccccttc gcaagccaaa     1260

gtatgatcag ggagtggaac ctgagctcga gcccgcagat gacctggatg gaggcacgga     1320

ggagcaggga gagcaggatt tccggaaata tgaggaaggc tttgacccct actctatgtt     1380

caccccagag cagatcatgg ggaaggatgt ccggctccta cgcatcaaga aggagggatc     1440

cttagacctg gccctggaag gcggtgtgga ctcccccatt gggaaggtgg tcgtttctgc     1500

tgtgtatgag cggggagctg ctgagcggca tggtggcatt gtgaaagggg acgagatcat     1560

ggcaatcaac ggcaagattg tgacagacta caccctggct gaggctgagg ctgccctgca     1620

gaaggcctgg aatcagggcg gggactggat cgaccttgtg gttgccgtct gccccccaaa     1680

ggagtatgac gatgagctga ccttcttctg aagtccaaaa ggggaaacca aattcaccgt     1740

taggaaacag tgagctccgg ccccacctcg tgaacacaaa gcctcggatc agccttgaga     1800

gaggccacac tacacacacc agatggcatc cttgggacct gaatctatca cccaggaatc     1860

tcaaactccc tttggccctg aaccagggcc agataaggaa cagctcgggc cactcttctg     1920

aaggccaacg tggaggaaag ggagcagcca gccatttggg agaagatctc aaggatccag     1980

actctcattc ctttcctctg gcccagtgaa tttggtctct cccagctctg ggggactcct     2040

tccttgaacc ctaataagac cccactggag tctctctctc tccatccctc tcctctgccc     2100

tctgctctaa ttgctgccag gattgtcact ccaaacctta ctctgagctc attaataaaa     2160

tagatttatt ttccagctta                                                 2180


<210> 13
<211> 533
<212> PRT
<213> Homo sapiens

<400> 13
Met Asp Arg Lys Val Ala Arg Glu Phe Arg His Lys Val Asp Phe Leu 
1               5                   10                  15      


Ile Glu Asn Asp Ala Glu Lys Asp Tyr Leu Tyr Asp Val Leu Arg Met 
            20                  25                  30          


Tyr His Gln Thr Met Asp Val Ala Val Leu Val Gly Asp Leu Lys Leu 
        35                  40                  45              


Val Ile Asn Glu Pro Ser Arg Leu Pro Leu Phe Asp Ala Ile Arg Pro 
    50                  55                  60                  


Leu Ile Pro Leu Lys His Gln Val Glu Tyr Asp Gln Leu Thr Pro Arg 
65                  70                  75                  80  


Arg Ser Arg Lys Leu Lys Glu Val Arg Leu Asp Arg Leu His Pro Glu 
                85                  90                  95      


Gly Leu Gly Leu Ser Val Arg Gly Gly Leu Glu Phe Gly Cys Gly Leu 
            100                 105                 110         


Phe Ile Ser His Leu Ile Lys Gly Gly Gln Ala Asp Ser Val Gly Leu 
        115                 120                 125             


Gln Val Gly Asp Glu Ile Val Arg Ile Asn Gly Tyr Ser Ile Ser Ser 
    130                 135                 140                 


Cys Thr His Glu Glu Val Ile Asn Leu Ile Arg Thr Lys Lys Thr Val 
145                 150                 155                 160 


Ser Ile Lys Val Arg His Ile Gly Leu Ile Pro Val Lys Ser Ser Pro 
                165                 170                 175     


Asp Glu Pro Leu Thr Trp Gln Tyr Val Asp Gln Phe Val Ser Glu Ser 
            180                 185                 190         


Gly Gly Val Arg Gly Ser Leu Gly Ser Pro Gly Asn Arg Glu Asn Lys 
        195                 200                 205             


Glu Lys Lys Val Phe Ile Ser Leu Val Gly Ser Arg Gly Leu Gly Cys 
    210                 215                 220                 


Ser Ile Ser Ser Gly Pro Ile Gln Lys Pro Gly Ile Phe Ile Ser His 
225                 230                 235                 240 


Val Lys Pro Gly Ser Leu Ser Ala Glu Val Gly Leu Glu Ile Gly Asp 
                245                 250                 255     


Gln Ile Val Glu Val Asn Gly Val Asp Phe Ser Asn Leu Asp His Lys 
            260                 265                 270         


Glu Gly Arg Glu Leu Phe Met Thr Asp Arg Glu Arg Leu Ala Glu Ala 
        275                 280                 285             


Arg Gln Arg Glu Leu Gln Arg Gln Glu Leu Leu Met Gln Lys Arg Leu 
    290                 295                 300                 


Ala Met Glu Ser Asn Lys Ile Leu Gln Glu Gln Gln Glu Met Glu Arg 
305                 310                 315                 320 


Gln Arg Arg Lys Glu Ile Ala Gln Lys Ala Ala Glu Glu Asn Glu Arg 
                325                 330                 335     


Tyr Arg Lys Glu Met Glu Gln Ile Val Glu Glu Glu Glu Lys Phe Lys 
            340                 345                 350         


Lys Gln Trp Glu Glu Asp Trp Gly Ser Lys Glu Gln Leu Leu Leu Pro 
        355                 360                 365             


Lys Thr Ile Thr Ala Glu Val His Pro Val Pro Leu Arg Lys Pro Lys 
    370                 375                 380                 


Tyr Asp Gln Gly Val Glu Pro Glu Leu Glu Pro Ala Asp Asp Leu Asp 
385                 390                 395                 400 


Gly Gly Thr Glu Glu Gln Gly Glu Gln Asp Phe Arg Lys Tyr Glu Glu 
                405                 410                 415     


Gly Phe Asp Pro Tyr Ser Met Phe Thr Pro Glu Gln Ile Met Gly Lys 
            420                 425                 430         


Asp Val Arg Leu Leu Arg Ile Lys Lys Glu Gly Ser Leu Asp Leu Ala 
        435                 440                 445             


Leu Glu Gly Gly Val Asp Ser Pro Ile Gly Lys Val Val Val Ser Ala 
    450                 455                 460                 


Val Tyr Glu Arg Gly Ala Ala Glu Arg His Gly Gly Ile Val Lys Gly 
465                 470                 475                 480 


Asp Glu Ile Met Ala Ile Asn Gly Lys Ile Val Thr Asp Tyr Thr Leu 
                485                 490                 495     


Ala Glu Ala Glu Ala Ala Leu Gln Lys Ala Trp Asn Gln Gly Gly Asp 
            500                 505                 510         


Trp Ile Asp Leu Val Val Ala Val Cys Pro Pro Lys Glu Tyr Asp Asp 
        515                 520                 525             


Glu Leu Thr Phe Phe 
    530             


<210> 14
<211> 695
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Glu Ala Pro Pro Arg Arg Leu Gly Leu Gly Pro Pro Pro Gly 
1               5                   10                  15      


Asp Ala Pro Arg Ala Glu Leu Val Ala Leu Thr Ala Val Gln Ser Glu 
            20                  25                  30          


Gln Gly Glu Ala Gly Gly Gly Gly Ser Pro Arg Arg Leu Gly Leu Leu 
        35                  40                  45              


Gly Ser Pro Leu Pro Pro Gly Ala Pro Leu Pro Gly Pro Gly Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Cys Gly Gln Arg Ser Ser Ala Ala His Lys Arg Tyr 
65                  70                  75                  80  


Arg Arg Leu Gln Asn Trp Val Tyr Asn Val Leu Glu Arg Pro Arg Gly 
                85                  90                  95      


Trp Ala Phe Val Tyr His Val Phe Ile Phe Leu Leu Val Phe Ser Cys 
            100                 105                 110         


Leu Val Leu Ser Val Leu Ser Thr Ile Gln Glu His Gln Glu Leu Ala 
        115                 120                 125             


Asn Glu Cys Leu Leu Ile Leu Glu Phe Val Met Ile Val Val Phe Gly 
    130                 135                 140                 


Leu Glu Tyr Ile Val Arg Val Trp Ser Ala Gly Cys Cys Cys Arg Tyr 
145                 150                 155                 160 


Arg Gly Trp Gln Gly Arg Phe Arg Phe Ala Arg Lys Pro Phe Cys Val 
                165                 170                 175     


Ile Asp Phe Ile Val Phe Val Ala Ser Val Ala Val Ile Ala Ala Gly 
            180                 185                 190         


Thr Gln Gly Asn Ile Phe Ala Thr Ser Ala Leu Arg Ser Met Arg Phe 
        195                 200                 205             


Leu Gln Ile Leu Arg Met Val Arg Met Asp Arg Arg Gly Gly Thr Trp 
    210                 215                 220                 


Lys Leu Leu Gly Ser Val Val Tyr Ala His Ser Lys Glu Leu Ile Thr 
225                 230                 235                 240 


Ala Trp Tyr Ile Gly Phe Leu Val Leu Ile Phe Ala Ser Phe Leu Val 
                245                 250                 255     


Tyr Leu Ala Glu Lys Asp Ala Asn Ser Asp Phe Ser Ser Tyr Ala Asp 
            260                 265                 270         


Ser Leu Trp Trp Gly Thr Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp 
        275                 280                 285             


Lys Thr Pro His Thr Trp Leu Gly Arg Val Leu Ala Ala Gly Phe Ala 
    290                 295                 300                 


Leu Leu Gly Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser 
305                 310                 315                 320 


Gly Phe Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe Glu 
                325                 330                 335     


Lys Arg Arg Met Pro Ala Ala Asn Leu Ile Gln Ala Ala Trp Arg Leu 
            340                 345                 350         


Tyr Ser Thr Asp Met Ser Arg Ala Tyr Leu Thr Ala Thr Trp Tyr Tyr 
        355                 360                 365             


Tyr Asp Ser Ile Leu Pro Ser Phe Arg Glu Leu Ala Leu Leu Phe Glu 
    370                 375                 380                 


His Val Gln Arg Ala Arg Asn Gly Gly Leu Arg Pro Leu Glu Val Arg 
385                 390                 395                 400 


Arg Ala Pro Val Pro Asp Gly Ala Pro Ser Arg Tyr Pro Pro Val Ala 
                405                 410                 415     


Thr Cys His Arg Pro Gly Ser Thr Ser Phe Cys Pro Gly Glu Ser Ser 
            420                 425                 430         


Arg Met Gly Ile Lys Asp Arg Ile Arg Met Gly Ser Ser Gln Arg Arg 
        435                 440                 445             


Thr Gly Pro Ser Lys Gln His Leu Ala Pro Pro Thr Met Pro Thr Ser 
    450                 455                 460                 


Pro Ser Ser Glu Gln Val Gly Glu Ala Thr Ser Pro Thr Lys Val Gln 
465                 470                 475                 480 


Lys Ser Trp Ser Phe Asn Asp Arg Thr Arg Phe Arg Ala Ser Leu Arg 
                485                 490                 495     


Leu Lys Pro Arg Thr Ser Ala Glu Asp Ala Pro Ser Glu Glu Val Ala 
            500                 505                 510         


Glu Glu Lys Ser Tyr Gln Cys Glu Leu Thr Val Asp Asp Ile Met Pro 
        515                 520                 525             


Ala Val Lys Thr Val Ile Arg Ser Ile Arg Ile Leu Lys Phe Leu Val 
    530                 535                 540                 


Ala Lys Arg Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys Asp 
545                 550                 555                 560 


Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Gly Arg Ile 
                565                 570                 575     


Lys Ser Leu Gln Thr Arg Val Asp Gln Ile Val Gly Arg Gly Pro Gly 
            580                 585                 590         


Asp Arg Lys Ala Arg Glu Lys Gly Asp Lys Gly Pro Ser Asp Ala Glu 
        595                 600                 605             


Val Val Asp Glu Ile Ser Met Met Gly Arg Val Val Lys Val Glu Lys 
    610                 615                 620                 


Gln Val Gln Ser Ile Glu His Lys Leu Asp Leu Leu Leu Gly Phe Tyr 
625                 630                 635                 640 


Ser Arg Cys Leu Arg Ser Gly Thr Ser Ala Ser Leu Gly Ala Val Gln 
                645                 650                 655     


Val Pro Leu Phe Asp Pro Asp Ile Thr Ser Asp Tyr His Ser Pro Val 
            660                 665                 670         


Asp His Glu Asp Ile Ser Val Ser Ala Gln Thr Leu Ser Ile Ser Arg 
        675                 680                 685             


Ser Val Ser Thr Asn Met Asp 
    690                 695 


<210> 15
<211> 4116
<212> DNA
<213> Homo sapiens

<400> 15
agccatgcgt ctctgagcgc cccgagcgcg cccccgcccc ggaccgtgcc cgggccccgg       60

cgcccccagc ccggcgccgc ccatggccga ggcccccccg cgccgcctcg gcctgggtcc      120

cccgcccggg gacgcccccc gcgcggagct agtggcgctc acggccgtgc agagcgaaca      180

gggcgaggcg ggcgggggcg gctccccgcg ccgcctcggc ctcctgggca gccccctgcc      240

gccgggcgcg cccctccctg ggccgggctc cggctcgggc tccgcctgcg gccagcgctc      300

ctcggccgcg cacaagcgct accgccgcct gcagaactgg gtctacaacg tgctggagcg      360

gccccgcggc tgggccttcg tctaccacgt cttcatattt ttgctggtct tcagctgcct      420

ggtgctgtct gtgctgtcca ctatccagga gcaccaggaa cttgccaacg agtgtctcct      480

catcttggaa ttcgtgatga tcgtggtttt cggcttggag tacatcgtcc gggtctggtc      540

cgccggatgc tgctgccgct accgaggatg gcagggtcgc ttccgctttg ccagaaagcc      600

cttctgtgtc atcgacttca tcgtgttcgt ggcctcggtg gccgtcatcg ccgcgggtac      660

ccagggcaac atcttcgcca cgtccgcgct gcgcagcatg cgcttcctgc agatcctgcg      720

catggtgcgc atggaccgcc gcggcggcac ctggaagctg ctgggctcag tggtctacgc      780

gcatagcaag gagctgatca ccgcctggta catcgggttc ctggtgctca tcttcgcctc      840

cttcctggtc tacctggctg agaaggacgc caactccgac ttctcctcct acgccgactc      900

gctctggtgg gggacgatta cattgacaac catcggctat ggtgacaaga caccgcacac      960

atggctgggc agggtcctgg ctgctggctt cgccttactg ggcatctctt tctttgccct     1020

gcctgccggc atcctaggct ccggctttgc cctgaaggtc caggagcagc accggcagaa     1080

gcacttcgag aagcggagga tgccggcagc caacctcatc caggctgcct ggcgcctgta     1140

ctccaccgat atgagccggg cctacctgac agccacctgg tactactatg acagtatcct     1200

cccatccttc agagagctgg ccctcttgtt tgagcacgtg caacgggccc gcaatggggg     1260

cctacggccc ctggaggtgc ggcgggcgcc ggtacccgac ggagcaccct cccgttaccc     1320

gcccgttgcc acctgccacc ggccgggcag cacctccttc tgccctgggg aaagcagccg     1380

gatgggcatc aaagaccgca tccgcatggg cagctcccag cggcggacgg gtccttccaa     1440

gcagcatctg gcacctccaa caatgcccac ctccccaagc agcgagcagg tgggtgaggc     1500

caccagcccc accaaggtgc aaaagagctg gagcttcaat gaccgcaccc gcttccgggc     1560

atctctgaga ctcaaacccc gcacctctgc tgaggatgcc ccctcagagg aagtagcaga     1620

ggagaagagc taccagtgtg agctcacggt ggacgacatc atgcctgctg tgaagacagt     1680

catccgctcc atcaggattc tcaagttcct ggtggccaaa aggaaattca aggagacact     1740

gcgaccgtac gacgtgaagg acgtcattga gcagtactca gcaggccacc tggacatgct     1800

gggccggatc aagagcctgc aaactcgggt ggaccaaatt gtgggtcggg ggcccgggga     1860

caggaaggcc cgggagaagg gcgacaaggg gccctccgac gcggaggtgg tggatgaaat     1920

cagcatgatg ggacgcgtgg tcaaggtgga gaagcaggtg cagtccatcg agcacaagct     1980

ggacctgctg ttgggcttct attcgcgctg cctgcgctct ggcacctcgg ccagcctggg     2040

cgccgtgcaa gtgccgctgt tcgaccccga catcacctcc gactaccaca gccctgtgga     2100

ccacgaggac atctccgtct ccgcacagac gctcagcatc tcccgctcgg tcagcaccaa     2160

catggactga gggacttctc agaggcaggg cagcacacgg ccagccccgc ggcctggcgc     2220

tccgactgcc ctctgaggcc tccggactcc tctcgtactt gaactcactc cctcacgggg     2280

agagagacca cacgcagtat tgagctgcct gagtgggcgt ggtacctgct gtgggtgcca     2340

gcgccccttc cccacctcag gagcgtgaga tgccaggtcg cacagagggc agcagcagcg     2400

gccgtcccgc ggcctctggg ccccccagtg ccctgcccac tccatcaagg ccctatgtgg     2460

cccacctggc aggggcacag ccccgggagt gggagcgggc gctggggccc tgggccctga     2520

cccagcttcc agctatgcaa ggtgaggtct ctggcccacc cttcggacac agcagggaag     2580

ccctcccgcc aagtccccgc cccacttggg ggtgggccaa ggtgccccca caggtaccca     2640

caaagcacag gaccctgcca caaggcaggt ggacaccata tatgcaaacc atgttaaata     2700

tgcaactttg gggaccccca tggggtctct ctgtccctcc cccattggga gctgggcccc     2760

cagcagtagc tggtctcagg ctgcttggcc accaccctgt ccctattctt tggcttatca     2820

ctccttcccc tcccagcatg gggcctgttt ctcccctgcc ctctcctaag ggcaatgcct     2880

gggcctttct tcccatttgc aagtgtcagc tcccaggggc tccctcctcc tgctgggtgg     2940

ccactcccct ccttggccct ccagacacca ctcatagtca gcacaggttt ctgtatcctc     3000

cccaaaactc ccagacagtg cttcgtggac gatcgcacaa acatagcctt ttagtttctc     3060

cagacaggaa gaaagcctct cacacttaaa catgcaatga cgtgacacac ttggagacat     3120

gagtgcagag ccactcagcc gctcctgggc ctctgcagca gatgccagtg gactggcctt     3180

gcagggtgac gaccactaag aggaagaccc ccaactccat ctgagcagga gaaggagctt     3240

tgaagtaacc cgagagctct ccaggcccca cccagacctt tacccgctcc ccttcttcaa     3300

gaagatctcc tcctctctgg tccaggagcc ctaacccact gcctctgcct gtccccaagg     3360

gcccgcctcc gtgtctccac agcacaactc gggcccaggc ctgacaccac tggagagacc     3420

ccaggcccac ttctagccag gcctgtgcct tcctagtcac tctaactccc agagagaata     3480

agaatgcatg taatagctat accaaccgcg catccggctt tcacatgcac tgtctcccct     3540

ccctccacac cccacttctt cacttcaatt ggcagcgcca catccaggcg tcagccccca     3600

ttcactccag gaacactttc ttatccccac ccctttgctc ctcttctgca aagccaatgc     3660

aggtggcagg aaggtgaggg gtagtggacc aatggcaacc ctctgtggga acaaggggcc     3720

gaggccacgc tgcctgcatc tcgtgctggg gacctgcatg cgccagcacc agggcttgga     3780

ctggatctta ctcagtccat ggtgcccagc ctctgcccca acatgccctc tgcatgtgac     3840

cgtcatgccc tggatggagc cactcctggc tcaccccacc tgcactgcac tgtccccaga     3900

gagccacccc tccacccact cagagacagc tgtggagagg gccaggagaa tgggattacc     3960

ctatgaccaa ggagacatgg gaagaagccc tccttccttc cacgatcgag gttccgccat     4020

caactcggtt ctcggatatg caagtacctc actttgttaa cttattaact tattggtttc     4080

attaaagttt tcaagaggaa aaaaaaaaaa aaaaaa                               4116


<210> 16
<211> 508
<212> DNA
<213> Homo sapiens

<400> 16
acgcgtccgg cttcccggcc ccgcgcgctg cccccgccac gcggttcggc ccaggcacca       60

actcggccgc ccgtgcgccc tgccccgccg cctgctccgc gcgttccctc cctccgcctc      120

gcctcgcttg ctcgctcgct ccctcccgat ttgggaaggc ggccgcgggg cgggcggggg      180

aggggcgggg cgggggaggg tgacatgtga gcggcgcgcg ccggtggcag gtggaaaggc      240

gagcggcatg gagcgcgtaa taagagagtt ggagtcggaa agagcagccc cagtcgccgg      300

ggaagcggga ggtcagtgcg ggctccggcg gcccccaggc tccgagcgcc cgcccgcggc      360

cccggcccgg cccctagccc ccgccgcccg cgcccgcccc gggtcgcccc tctggccccg      420

ggtccgagcc atgcgtctct gagcgccccg agcgcgcccc cgccccggac cgtgcccggg      480

ccccggcgcc cccagcccgg cgccgccc                                         508


<210> 17
<211> 453
<212> PRT
<213> Homo sapiens

<400> 17
Met Gly Glu Asn Asp Pro Pro Ala Val Glu Ala Pro Phe Ser Phe Arg 
1               5                   10                  15      


Ser Leu Phe Gly Leu Asp Asp Leu Lys Ile Ser Pro Val Ala Pro Asp 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Gln Ile Leu Ser Leu Leu Pro Leu Lys Phe 
        35                  40                  45              


Phe Pro Ile Ile Val Ile Gly Ile Ile Ala Leu Ile Leu Ala Leu Ala 
    50                  55                  60                  


Ile Gly Leu Gly Ile His Phe Asp Cys Ser Gly Lys Tyr Arg Cys Arg 
65                  70                  75                  80  


Ser Ser Phe Lys Cys Ile Glu Leu Ile Ala Arg Cys Asp Gly Val Ser 
                85                  90                  95      


Asp Cys Lys Asp Gly Glu Asp Glu Tyr Arg Cys Val Arg Val Gly Gly 
            100                 105                 110         


Gln Asn Ala Val Leu Gln Val Phe Thr Ala Ala Ser Trp Lys Thr Met 
        115                 120                 125             


Cys Ser Asp Asp Trp Lys Gly His Tyr Ala Asn Val Ala Cys Ala Gln 
    130                 135                 140                 


Leu Gly Phe Pro Ser Tyr Val Ser Ser Asp Asn Leu Arg Val Ser Ser 
145                 150                 155                 160 


Leu Glu Gly Gln Phe Arg Glu Glu Phe Val Ser Ile Asp His Leu Leu 
                165                 170                 175     


Pro Asp Asp Lys Val Thr Ala Leu His His Ser Val Tyr Val Arg Glu 
            180                 185                 190         


Gly Cys Ala Ser Gly His Val Val Thr Leu Gln Cys Thr Ala Cys Gly 
        195                 200                 205             


His Arg Arg Gly Tyr Ser Ser Arg Ile Val Gly Gly Asn Met Ser Leu 
    210                 215                 220                 


Leu Ser Gln Trp Pro Trp Gln Ala Ser Leu Gln Phe Gln Gly Tyr His 
225                 230                 235                 240 


Leu Cys Gly Gly Ser Val Ile Thr Pro Leu Trp Ile Ile Thr Ala Ala 
                245                 250                 255     


His Cys Val Tyr Asp Leu Tyr Leu Pro Lys Ser Trp Thr Ile Gln Val 
            260                 265                 270         


Gly Leu Val Ser Leu Leu Asp Asn Pro Ala Pro Ser His Leu Val Glu 
        275                 280                 285             


Lys Ile Val Tyr His Ser Lys Tyr Lys Pro Lys Arg Leu Gly Asn Asp 
    290                 295                 300                 


Ile Ala Leu Met Lys Leu Ala Gly Pro Leu Thr Phe Asn Glu Met Ile 
305                 310                 315                 320 


Gln Pro Val Cys Leu Pro Asn Ser Glu Glu Asn Phe Pro Asp Gly Lys 
                325                 330                 335     


Val Cys Trp Thr Ser Gly Trp Gly Ala Thr Glu Asp Gly Gly Asp Ala 
            340                 345                 350         


Ser Pro Val Leu Asn His Ala Ala Val Pro Leu Ile Ser Asn Lys Ile 
        355                 360                 365             


Cys Asn His Arg Asp Val Tyr Gly Gly Ile Ile Ser Pro Ser Met Leu 
    370                 375                 380                 


Cys Ala Gly Tyr Leu Thr Gly Gly Val Asp Ser Cys Gln Gly Asp Ser 
385                 390                 395                 400 


Gly Gly Pro Leu Val Cys Gln Glu Arg Arg Leu Trp Lys Leu Val Gly 
                405                 410                 415     


Ala Thr Ser Phe Gly Ile Gly Cys Ala Glu Val Asn Lys Pro Gly Val 
            420                 425                 430         


Tyr Thr Arg Val Thr Ser Phe Leu Asp Trp Ile His Glu Gln Met Glu 
        435                 440                 445             


Arg Asp Leu Lys Thr 
    450             


<210> 18
<211> 2460
<212> DNA
<213> Homo sapiens

<400> 18
accgggcacc ggacggctcg ggtactttcg ttcttaatta ggtcatgccc gtgtgagcca       60

ggaaagggct gtgtttatgg gaagccagta acactgtggc ctactatctc ttccgtggtg      120

ccatctacat ttttgggact cgggaattat gaggtagagg tggaggcgga gccggatgtc      180

agaggtcctg aaatagtcac catgggggaa aatgatccgc ctgctgttga agcccccttc      240

tcattccgat cgctttttgg ccttgatgat ttgaaaataa gtcctgttgc accagatgca      300

gatgctgttg ctgcacagat cctgtcactg ctgccattga agttttttcc aatcatcgtc      360

attgggatca ttgcattgat attagcactg gccattggtc tgggcatcca cttcgactgc      420

tcagggaagt acagatgtcg ctcatccttt aagtgtatcg agctgatagc tcgatgtgac      480

ggagtctcgg attgcaaaga cggggaggac gagtaccgct gtgtccgggt gggtggtcag      540

aatgccgtgc tccaggtgtt cacagctgct tcgtggaaga ccatgtgctc cgatgactgg      600

aagggtcact acgcaaatgt tgcctgtgcc caactgggtt tcccaagcta tgtgagttca      660

gataacctca gagtgagctc gctggagggg cagttccggg aggagtttgt gtccatcgat      720

cacctcttgc cagatgacaa ggtgactgca ttacaccact cagtatatgt gagggaggga      780

tgtgcctctg gccacgtggt taccttgcag tgcacagcct gtggtcatag aaggggctac      840

agctcacgca tcgtgggtgg aaacatgtcc ttgctctcgc agtggccctg gcaggccagc      900

cttcagttcc agggctacca cctgtgcggg ggctctgtca tcacgcccct gtggatcatc      960

actgctgcac actgtgttta tgacttgtac ctccccaagt catggaccat ccaggtgggt     1020

ctagtttccc tgttggacaa tccagcccca tcccacttgg tggagaagat tgtctaccac     1080

agcaagtaca agccaaagag gctgggcaat gacatcgccc ttatgaagct ggccgggcca     1140

ctcacgttca atgaaatgat ccagcctgtg tgcctgccca actctgaaga gaacttcccc     1200

gatggaaaag tgtgctggac gtcaggatgg ggggccacag aggatggagg tgacgcctcc     1260

cctgtcctga accacgcggc cgtccctttg atttccaaca agatctgcaa ccacagggac     1320

gtgtacggtg gcatcatctc cccctccatg ctctgcgcgg gctacctgac gggtggcgtg     1380

gacagctgcc agggggacag cggggggccc ctggtgtgtc aagagaggag gctgtggaag     1440

ttagtgggag cgaccagctt tggcatcggc tgcgcagagg tgaacaagcc tggggtgtac     1500

acccgtgtca cctccttcct ggactggatc cacgagcaga tggagagaga cctaaaaacc     1560

tgaagaggaa ggggacaagt agccacctga gttcctgagg tgatgaagac agcccgatcc     1620

tcccctggac tcccgtgtag gaacctgcac acgagcagac acccttggag ctctgagttc     1680

cggcaccagt agcaggcccg aaagaggcac ccttccatct gattccagca caaccttcaa     1740

gctgcttttt gttttttgtt tttttgagat ggagtctcgc tctgttgccc aggctggagt     1800

gcagtggcga aatccctgct cactgcagcc tccgcttccc tggttcaagc gattctcttg     1860

cctcagcttc cccagtagct gggaccacag gtgcccgcca ccacacccaa ctaatttttg     1920

tatttttagt agagacaggg tttcaccatg ttggccaggc tgctctcaaa cccctgacct     1980

caaatgatgt gcctgcttca gcctcccaca gtgctgggat tacaggcatg ggccaccacg     2040

cctagcctca cgctcctttc tgatcttcac taagaacaaa agaagcagca acttgcaagg     2100

gcggcctttc ccactggtcc atctggtttt ctctccaggg gtcttgcaaa attcctgacg     2160

agataagcag ttatgtgacc tcacgtgcaa agccaccaac agccactcag aaaagacgca     2220

ccagcccaga agtgcagaac tgcagtcact gcacgttttc atctctaggg accagaacca     2280

aacccaccct ttctacttcc aagacttatt ttcacatgtg gggaggttaa tctaggaatg     2340

actcgtttaa ggcctatttt catgatttct ttgtagcatt tggtgcttga cgtattattg     2400

tcctttgatt ccaaataata tgtttccttc cctcattgaa aaaaaaaaaa aaaaaaaaaa     2460


<210> 19
<211> 1775
<212> PRT
<213> Homo sapiens

<400> 19
Met Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Phe Ala Val Thr Leu Ala Pro Thr Gly Pro His Ser Leu 
            20                  25                  30          


Asp Pro Gly Leu Ser Phe Leu Lys Ser Leu Leu Ser Thr Leu Asp Gln 
        35                  40                  45              


Ala Pro Gln Gly Ser Leu Ser Arg Ser Arg Phe Phe Thr Phe Leu Ala 
    50                  55                  60                  


Asn Ile Ser Ser Ser Phe Glu Pro Gly Arg Met Gly Glu Gly Pro Val 
65                  70                  75                  80  


Gly Glu Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe 
                85                  90                  95      


Leu Val Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu 
            100                 105                 110         


Leu Gly Asp Met Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp 
        115                 120                 125             


Phe Leu Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Val Leu 
    130                 135                 140                 


Leu Gly Ala Leu Val Pro Gly Gly Pro Pro Thr Pro Thr Arg Pro Pro 
145                 150                 155                 160 


Cys Thr Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu 
                165                 170                 175     


Pro Ser Leu Leu Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val 
            180                 185                 190         


Gln Val Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly 
        195                 200                 205             


Arg Glu Ala Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr 
    210                 215                 220                 


Pro Thr Gly Glu Leu Gly Ser Lys Glu Ala Leu Trp Gly Gly Leu Leu 
225                 230                 235                 240 


Arg Thr Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu 
                245                 250                 255     


Arg Val Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Leu Gly Gln 
            260                 265                 270         


Pro Glu Pro Asp Thr Asn Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln 
        275                 280                 285             


Leu Leu Leu Trp Gly Val Arg His Asn Leu Ser Trp Asp Val Gln Ala 
    290                 295                 300                 


Leu Gly Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His 
305                 310                 315                 320 


Cys Leu Ser Thr Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ser Ala 
                325                 330                 335     


His Ile Ser Pro Arg Gln Arg Arg Ala Ile Thr Val Glu Ala Leu Cys 
            340                 345                 350         


Glu Asn His Leu Gly Pro Ala Pro Pro Tyr Ser Ile Ser Asn Phe Ser 
        355                 360                 365             


Ile His Leu Leu Cys Gln His Thr Lys Pro Ala Thr Pro Gln Pro His 
    370                 375                 380                 


Pro Ser Thr Thr Ala Ile Cys Gln Thr Ala Val Trp Tyr Ala Val Ser 
385                 390                 395                 400 


Trp Ala Pro Gly Ala Gln Gly Trp Leu Gln Ala Cys His Asp Gln Phe 
                405                 410                 415     


Pro Asp Glu Phe Leu Asp Ala Ile Cys Ser Asn Leu Ser Phe Ser Ala 
            420                 425                 430         


Leu Ser Gly Ser Asn Arg Arg Leu Val Lys Arg Leu Cys Ala Gly Leu 
        435                 440                 445             


Leu Pro Pro Pro Thr Ser Cys Pro Glu Gly Leu Pro Pro Val Pro Leu 
    450                 455                 460                 


Thr Pro Asp Ile Phe Trp Gly Cys Phe Leu Glu Asn Glu Thr Leu Trp 
465                 470                 475                 480 


Ala Glu Arg Leu Cys Gly Glu Ala Ser Leu Gln Ala Val Pro Pro Ser 
                485                 490                 495     


Asn Gln Ala Trp Val Gln His Val Cys Gln Gly Pro Thr Pro Asp Val 
            500                 505                 510         


Thr Ala Ser Pro Pro Cys His Ile Gly Pro Cys Gly Glu Arg Cys Pro 
        515                 520                 525             


Asp Gly Gly Ser Phe Leu Val Met Val Cys Ala Asn Asp Thr Met Tyr 
    530                 535                 540                 


Glu Val Leu Val Pro Phe Trp Pro Trp Leu Ala Gly Gln Cys Arg Ile 
545                 550                 555                 560 


Ser Arg Gly Gly Asn Asp Thr Cys Phe Leu Glu Gly Leu Leu Gly Pro 
                565                 570                 575     


Leu Leu Pro Ser Leu Pro Pro Leu Gly Pro Ser Pro Leu Cys Leu Thr 
            580                 585                 590         


Pro Gly Pro Phe Leu Leu Gly Met Leu Ser Gln Leu Pro Arg Cys Gln 
        595                 600                 605             


Ser Ser Val Pro Ala Leu Ala His Pro Thr Arg Leu His Tyr Leu Leu 
    610                 615                 620                 


Arg Leu Leu Thr Phe Leu Leu Gly Pro Gly Ala Gly Gly Ala Glu Ala 
625                 630                 635                 640 


Gln Gly Met Leu Gly Arg Ala Leu Leu Leu Ser Ser Leu Pro Asp Asn 
                645                 650                 655     


Cys Ser Phe Trp Asp Ala Phe Arg Pro Glu Gly Arg Arg Ser Val Leu 
            660                 665                 670         


Arg Thr Ile Gly Glu Tyr Leu Glu Gln Asp Glu Glu Gln Pro Thr Pro 
        675                 680                 685             


Ser Gly Phe Glu Pro Thr Val Asn Pro Ser Ser Gly Ile Ser Lys Met 
    690                 695                 700                 


Glu Leu Leu Ala Cys Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg 
705                 710                 715                 720 


Glu Lys Ser Val Trp Ala Leu Gln Ile Leu Val Gln Ala Tyr Leu His 
                725                 730                 735     


Met Pro Pro Glu Asn Leu Gln Gln Leu Val Leu Ser Ala Glu Arg Glu 
            740                 745                 750         


Ala Ala Gln Gly Phe Leu Thr Leu Met Leu Gln Gly Lys Leu Gln Gly 
        755                 760                 765             


Lys Leu Gln Val Pro Pro Ser Glu Glu Gln Ala Leu Gly Arg Leu Thr 
    770                 775                 780                 


Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile 
785                 790                 795                 800 


Asp Leu Ser Pro Leu Ile Pro Phe Leu Ala Val Ser Asp Leu Met Arg 
                805                 810                 815     


Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu Ala Ala Ile Arg 
            820                 825                 830         


Asp Tyr Ser Pro Gly Met Arg Pro Glu Gln Lys Glu Ala Leu Ala Lys 
        835                 840                 845             


Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro Ala Trp Pro Gln 
    850                 855                 860                 


Glu Leu Leu Trp Ala Val Leu Pro Leu Leu Pro His Leu Pro Leu Glu 
865                 870                 875                 880 


Asn Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala Leu Glu Asp Ser 
                885                 890                 895     


Trp Pro Ala Ala Gly Leu Gly Pro Gly His Ala Arg His Val Leu Arg 
            900                 905                 910         


Ser Leu Val Asn Gln Ser Val Gln Asp Gly Glu Glu Gln Val Arg Arg 
        915                 920                 925             


Leu Gly Pro Leu Ala Cys Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu 
    930                 935                 940                 


Val Pro Leu Ser Asp Pro Thr Gly Pro Val Glu Arg Gly Leu Leu Glu 
945                 950                 955                 960 


Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu 
                965                 970                 975     


Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Ala Val Leu Ser Pro Arg 
            980                 985                 990         


Glu Leu Arg Val Trp Ala Pro Leu  Phe Ser Gln Leu Gly  Leu Arg Phe 
        995                 1000                 1005             


Leu Gln  Glu Leu Ser Glu Pro  Gln Leu Arg Ala Met  Leu Pro Val 
    1010                 1015                 1020             


Leu Gln  Gly Thr Ser Val Thr  Pro Ala Gln Ala Val  Leu Leu Leu 
    1025                 1030                 1035             


Gly Arg  Leu Leu Pro Arg His  Asp Leu Ser Leu Glu  Glu Leu Cys 
    1040                 1045                 1050             


Ser Leu  His Leu Leu Leu Pro  Gly Leu Ser Pro Gln  Thr Leu Gln 
    1055                 1060                 1065             


Ala Ile  Pro Arg Arg Val Leu  Val Gly Ala Cys Ser  Cys Leu Ala 
    1070                 1075                 1080             


Pro Glu  Leu Ser Arg Leu Ser  Ala Cys Gln Thr Ala  Ala Leu Leu 
    1085                 1090                 1095             


Gln Thr  Phe Arg Val Lys Asp  Gly Val Lys Asn Met  Gly Thr Thr 
    1100                 1105                 1110             


Gly Ala  Gly Pro Ala Val Cys  Ile Pro Gly Gln Pro  Ile Pro Thr 
    1115                 1120                 1125             


Thr Trp  Pro Asp Cys Leu Leu  Pro Leu Leu Pro Leu  Lys Leu Leu 
    1130                 1135                 1140             


Gln Leu  Asp Ser Leu Ala Leu  Leu Ala Asn Arg Arg  Arg Tyr Trp 
    1145                 1150                 1155             


Glu Leu  Pro Trp Ser Glu Gln  Gln Ala Gln Phe Leu  Trp Lys Lys 
    1160                 1165                 1170             


Met Gln  Val Pro Thr Asn Leu  Thr Leu Arg Asn Leu  Gln Ala Leu 
    1175                 1180                 1185             


Gly Thr  Leu Ala Gly Gly Met  Ser Cys Glu Phe Leu  Gln Gln Ile 
    1190                 1195                 1200             


Asn Ser  Met Val Asp Phe Leu  Glu Val Val His Met  Ile Tyr Gln 
    1205                 1210                 1215             


Leu Pro  Thr Arg Val Arg Gly  Ser Leu Arg Ala Cys  Ile Trp Ala 
    1220                 1225                 1230             


Glu Leu  Gln Arg Arg Met Ala  Met Pro Glu Pro Glu  Trp Thr Thr 
    1235                 1240                 1245             


Val Gly  Pro Glu Leu Asn Gly  Leu Asp Ser Lys Leu  Leu Leu Asp 
    1250                 1255                 1260             


Leu Pro  Ile Gln Leu Met Asp  Arg Leu Ser Asn Glu  Ser Ile Met 
    1265                 1270                 1275             


Leu Val  Val Glu Leu Val Gln  Arg Ala Pro Glu Gln  Leu Leu Ala 
    1280                 1285                 1290             


Leu Thr  Pro Leu His Gln Ala  Ala Leu Ala Glu Arg  Ala Leu Gln 
    1295                 1300                 1305             


Asn Leu  Ala Pro Lys Glu Thr  Pro Val Ser Gly Glu  Val Leu Glu 
    1310                 1315                 1320             


Thr Leu  Gly Pro Leu Val Gly  Phe Leu Gly Thr Glu  Ser Thr Arg 
    1325                 1330                 1335             


Gln Ile  Pro Leu Gln Ile Leu  Leu Ser His Leu Ser  Gln Leu Gln 
    1340                 1345                 1350             


Gly Phe  Cys Leu Gly Glu Thr  Phe Ala Thr Glu Leu  Gly Trp Leu 
    1355                 1360                 1365             


Leu Leu  Gln Glu Ser Val Leu  Gly Lys Pro Glu Leu  Trp Ser Gln 
    1370                 1375                 1380             


Asp Glu  Val Glu Gln Ala Gly  Arg Leu Val Phe Thr  Leu Ser Thr 
    1385                 1390                 1395             


Glu Ala  Ile Ser Leu Ile Pro  Arg Glu Ala Leu Gly  Pro Glu Thr 
    1400                 1405                 1410             


Leu Glu  Arg Leu Leu Glu Lys  Gln Gln Ser Trp Glu  Gln Ser Arg 
    1415                 1420                 1425             


Val Gly  Gln Leu Cys Arg Glu  Pro Gln Leu Ala Ala  Lys Lys Ala 
    1430                 1435                 1440             


Ala Leu  Val Ala Gly Val Val  Arg Pro Ala Ala Glu  Asp Leu Pro 
    1445                 1450                 1455             


Glu Pro  Val Pro Asn Cys Ala  Asp Val Arg Gly Thr  Phe Pro Ala 
    1460                 1465                 1470             


Ala Trp  Ser Ala Thr Gln Ile  Ala Glu Met Glu Leu  Ser Asp Phe 
    1475                 1480                 1485             


Glu Asp  Cys Leu Thr Leu Phe  Ala Gly Asp Pro Gly  Leu Gly Pro 
    1490                 1495                 1500             


Glu Glu  Leu Arg Ala Ala Met  Gly Lys Ala Lys Gln  Leu Trp Gly 
    1505                 1510                 1515             


Pro Pro  Arg Gly Phe Arg Pro  Glu Gln Ile Leu Gln  Leu Gly Arg 
    1520                 1525                 1530             


Leu Leu  Ile Gly Leu Gly Asp  Arg Glu Leu Gln Glu  Leu Ile Leu 
    1535                 1540                 1545             


Val Asp  Trp Gly Val Leu Ser  Thr Leu Gly Gln Ile  Asp Gly Trp 
    1550                 1555                 1560             


Ser Thr  Thr Gln Leu Arg Ile  Val Val Ser Ser Phe  Leu Arg Gln 
    1565                 1570                 1575             


Ser Gly  Arg His Val Ser His  Leu Asp Phe Val His  Leu Thr Ala 
    1580                 1585                 1590             


Leu Gly  Tyr Thr Leu Cys Gly  Leu Arg Pro Glu Glu  Leu Gln His 
    1595                 1600                 1605             


Ile Ser  Ser Trp Glu Phe Ser  Gln Ala Ala Leu Phe  Leu Gly Thr 
    1610                 1615                 1620             


Leu His  Leu Gln Cys Ser Glu  Glu Gln Leu Glu Val  Leu Ala His 
    1625                 1630                 1635             


Leu Leu  Val Leu Pro Gly Gly  Phe Gly Pro Ile Ser  Asn Trp Gly 
    1640                 1645                 1650             


Pro Glu  Ile Phe Thr Glu Ile  Gly Thr Ile Ala Ala  Gly Ile Pro 
    1655                 1660                 1665             


Asp Leu  Ala Leu Ser Ala Leu  Leu Arg Gly Gln Ile  Gln Gly Val 
    1670                 1675                 1680             


Thr Pro  Leu Ala Ile Ser Val  Ile Pro Pro Pro Lys  Phe Ala Val 
    1685                 1690                 1695             


Val Phe  Ser Pro Ile Gln Leu  Ser Ser Leu Thr Ser  Ala Gln Ala 
    1700                 1705                 1710             


Val Ala  Val Thr Pro Glu Gln  Met Ala Phe Leu Ser  Pro Glu Gln 
    1715                 1720                 1725             


Arg Arg  Ala Val Ala Trp Ala  Gln His Glu Gly Lys  Glu Ser Pro 
    1730                 1735                 1740             


Glu Gln  Gln Gly Arg Ser Thr  Ala Trp Gly Leu Gln  Asp Trp Ser 
    1745                 1750                 1755             


Arg Pro  Ser Trp Ser Leu Val  Leu Thr Ile Ser Phe  Leu Gly His 
    1760                 1765                 1770             


Leu Leu  
    1775 


<210> 20
<211> 5515
<212> DNA
<213> Homo sapiens

<400> 20
gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac       60

cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg      120

ctgctgctgc tgtcctttgc agtgactctg gcccctactg ggcctcattc cctggaccct      180

ggtctctcct tcctgaagtc attgctctcc actctggacc aggctcccca gggctccctg      240

agccgctcac ggttctttac attcctggcc aacatttctt cttcctttga gcctgggaga      300

atgggggaag gaccagtagg agagccccca cctctccagc cgcctgctct gcggctccat      360

gattttctag tgacactgag aggtagcccc gactgggagc caatgctagg gctgctaggg      420

gatatgctgg cactgctggg acaggagcag actccccgag atttcctggt gcaccaggca      480

ggggtgctgg gtggacttgt ggaggtgctg ctgggagcct tagttcctgg gggcccccct      540

accccaactc ggcccccatg cacccgtgat gggccgtctg actgtgtcct ggctgctgac      600

tggttgcctt ctctgctgct gttgttagag ggcacacgct ggcaagctct ggtgcaggtg      660

cagcccagtg tggaccccac caatgccaca ggcctcgatg ggagggaggc agctcctcac      720

tttttgcagg gtctgttggg tttgcttacc ccaacagggg agctaggctc caaggaggct      780

ctttggggcg gtctgctacg cacagtgggg gcccccctct atgctgcctt tcaggagggg      840

ctgctccgtg tcactcactc cctgcaggat gaggtcttct ccattttggg gcagccagag      900

cctgatacca atgggcagtg ccagggaggt aaccttcaac agctgctctt atggggcgtc      960

cggcacaacc tttcctggga tgtccaggcg ctgggctttc tgtctggatc accaccccca     1020

ccccctgccc tccttcactg cctgagcacg ggcgtgcctc tgcccagagc ttctcagccg     1080

tcagcccaca tcagcccacg ccaacggcga gccatcactg tggaggccct ctgtgagaac     1140

cacttaggcc cagcaccacc ctacagcatt tccaacttct ccatccactt gctctgccag     1200

cacaccaagc ctgccactcc acagccccat cccagcacca ctgccatctg ccagacagct     1260

gtgtggtatg cagtgtcctg ggcaccaggt gcccaaggct ggctacaggc ctgccacgac     1320

cagtttcctg atgagttttt ggatgcgatc tgcagtaacc tctccttttc agccctgtct     1380

ggctccaacc gccgcctggt gaagcggctc tgtgctggcc tgctcccacc ccctaccagc     1440

tgccctgaag gcctgccccc tgttcccctc accccagaca tcttttgggg ctgcttcttg     1500

gagaatgaga ctctgtgggc tgagcgactg tgtggggagg caagtctaca ggctgtgccc     1560

cccagcaacc aggcttgggt ccagcatgtg tgccagggcc ccaccccaga tgtcactgcc     1620

tccccaccat gccacattgg accctgtggg gaacgctgcc cggatggggg cagcttcctg     1680

gtgatggtct gtgccaatga caccatgtat gaggtcctgg tgcccttctg gccttggcta     1740

gcaggccaat gcaggataag tcgtgggggc aatgacactt gcttcctaga agggctgctg     1800

ggcccccttc tgccctctct gccaccactg ggaccatccc cactctgtct gacccctggc     1860

cccttcctcc ttggcatgct atcccagttg ccacgctgtc agtcctctgt cccagctctt     1920

gctcacccca cacgcctaca ctatctcctc cgcctgctga ccttcctctt gggtccaggg     1980

gctgggggcg ctgaggccca ggggatgctg ggtcgggccc tactgctctc cagtctccca     2040

gacaactgct ccttctggga tgcctttcgc ccagagggcc ggcgcagtgt gctacggacg     2100

attggggaat acctggaaca agatgaggag cagccaaccc catcaggctt tgaacccact     2160

gtcaacccca gctctggtat aagcaagatg gagctgctgg cctgctttag tcctgtgctg     2220

tgggatctgc tccagaggga aaagagtgtt tgggccctgc agattctagt gcaggcgtac     2280

ctgcatatgc ccccagaaaa cctccagcag ctggtgcttt cagcagagag ggaggctgca     2340

cagggcttcc tgacactcat gctgcagggg aagctgcagg ggaagctgca ggtaccacca     2400

tccgaggagc aggccctggg tcgcctgaca gccctgctgc tccagcggta cccacgcctc     2460

acctcccagc tcttcattga cctgtcacca ctcatccctt tcttggctgt ctctgacctg     2520

atgcgcttcc caccatccct gttagccaac gacagtgtcc tggctgccat ccgggattac     2580

agcccaggaa tgaggcctga acagaaggag gctctggcaa agcgactgct ggcccctgaa     2640

ctgtttgggg aagtgcctgc ctggccccag gagctgctgt gggcagtgct gcccctgctc     2700

ccccacctcc ctctggagaa ctttttgcag ctcagccctc accagatcca ggccctggag     2760

gatagctggc cagcagcagg tctggggcca gggcatgccc gccatgtgct gcgcagcctg     2820

gtaaaccaga gtgtccagga tggtgaggag caggtacgca ggcttgggcc cctcgcctgt     2880

ttcctgagcc ctgaggagct gcagagccta gtgcccctga gtgatccaac ggggccagta     2940

gaacgggggc tgctggaatg tgcagccaat gggaccctca gcccagaagg acgggtggca     3000

tatgaacttc tgggtgtgtt gcgctcatct ggaggagcgg tgctgagccc ccgggagctg     3060

cgggtctggg cccctctctt ctctcagctg ggcctccgct tccttcagga gctgtcagag     3120

ccccagctta gagccatgct tcctgtcctg cagggaacta gtgttacacc tgctcaggct     3180

gtcctgctgc ttggacggct ccttcctagg cacgatctat ccctggagga actctgctcc     3240

ttgcaccttc tgctaccagg cctcagcccc cagacactcc aggccatccc taggcgagtc     3300

ctggtcgggg cttgttcctg cctggcccct gaactgtcac gcctctcagc ctgccagacc     3360

gcagcactgc tgcagacctt tcgggttaaa gatggtgtta aaaatatggg tacaacaggt     3420

gctggtccag ctgtgtgtat ccctggtcag cctattccca ccacctggcc agactgcctg     3480

cttcccctgc tcccattaaa gctgctacaa ctggattcct tggctcttct ggcaaatcga     3540

agacgctact gggagctgcc ctggtctgag cagcaggcac agtttctctg gaagaagatg     3600

caagtaccca ccaaccttac cctcaggaat ctgcaggctc tgggcaccct ggcaggaggc     3660

atgtcctgtg agtttctgca gcagatcaac tccatggtag acttccttga agtggtgcac     3720

atgatctatc agctgcccac tagagttcga gggagcctga gggcctgtat ctgggcagag     3780

ctacagcgga ggatggcaat gccagaacca gaatggacaa ctgtagggcc agaactgaac     3840

gggctggata gcaagctact cctggactta ccgatccagt tgatggacag actatccaat     3900

gaatccatta tgttggtggt ggagctggtg caaagagctc cagagcagct gctggcactg     3960

acccccctcc accaggcagc cctggcagag agggcactac aaaacctggc tccaaaggag     4020

actccagtct caggggaagt gctggagacc ttaggccctt tggttggatt cctggggaca     4080

gagagcacac gacagatccc cctacagatc ctgctgtccc atctcagtca gctgcaaggc     4140

ttctgcctag gagagacatt tgccacagag ctgggatggc tgctattgca ggagtctgtt     4200

cttgggaaac cagagttgtg gagccaggat gaagtagagc aagctggacg cctagtattc     4260

actctgtcta ctgaggcaat ttccttgatc cccagggagg ccttgggtcc agagaccctg     4320

gagcggcttc tagaaaagca gcagagctgg gagcagagca gagttggaca gctgtgtagg     4380

gagccacagc ttgctgccaa gaaagcagcc ctggtagcag gggtggtgcg accagctgct     4440

gaggatcttc cagaacctgt gccaaattgt gcagatgtac gagggacatt cccagcagcc     4500

tggtctgcaa cccagattgc agagatggag ctctcagact ttgaggactg cctgacatta     4560

tttgcaggag acccaggact tgggcctgag gaactgcggg cagccatggg caaagcaaaa     4620

cagttgtggg gtcccccccg gggatttcgt cctgagcaga tcctgcagct tggtaggctc     4680

ttaataggtc taggagatcg ggaactacag gagctgatcc tagtggactg gggagtgctg     4740

agcaccctgg ggcagataga tggctggagc accactcagc tccgcattgt ggtctccagt     4800

ttcctacggc agagtggtcg gcatgtgagc cacctggact tcgttcatct gacagcgctg     4860

ggttatactc tctgtggact gcggccagag gagctccagc acatcagcag ttgggagttc     4920

agccaagcag ctctcttcct cggcaccctg catctccagt gctctgagga acaactggag     4980

gttctggccc acctacttgt actgcctggt gggtttggcc caatcagtaa ctgggggcct     5040

gagatcttca ctgaaattgg caccatagca gctgggatcc cagacctggc tctttcagca     5100

ctgctgcggg gacagatcca gggcgttact cctcttgcca tttctgtcat ccctcctcct     5160

aaatttgctg tggtgtttag tcccatccaa ctatctagtc tcaccagtgc tcaggctgtg     5220

gctgtcactc ctgagcaaat ggcctttctg agtcctgagc agcgacgagc agttgcatgg     5280

gcccaacatg agggaaagga gagcccagaa cagcaaggtc gaagtacagc ctggggcctc     5340

caggactggt cacgaccttc ctggtccctg gtattgacta tcagcttcct tggccacctg     5400

ctatgagcct gtctctacag tagaaggaga ttgtggggag agaaatctta agtcataatg     5460

aataaagtgc aaacagaagt gcatcctgat tattttcaga agctgatgag gaata          5515


<210> 21
<211> 585
<212> PRT
<213> Homo sapiens

<400> 21
Met Glu Asp Ser Gln Asp Leu Asn Glu Gln Ser Val Lys Lys Thr Cys 
1               5                   10                  15      


Thr Glu Ser Asp Val Ser Gln Ser Gln Asn Ser Arg Ser Met Glu Met 
            20                  25                  30          


Gln Asp Leu Ala Ser Pro His Thr Leu Val Gly Gly Gly Asp Thr Pro 
        35                  40                  45              


Gly Ser Ser Lys Leu Glu Lys Ser Asn Leu Ser Ser Thr Ser Val Thr 
    50                  55                  60                  


Thr Asn Gly Thr Gly Val Ile Thr Ser Ser Gly Tyr Ser Pro Arg Ser 
65                  70                  75                  80  


Ala His Gln Tyr Ser Pro Gln Leu Tyr Pro Ser Lys Pro Tyr Pro His 
                85                  90                  95      


Ile Leu Ser Thr Pro Ala Ala Gln Thr Met Ser Ala Tyr Ala Gly Gln 
            100                 105                 110         


Thr Gln Tyr Ser Gly Met Gln Gln Pro Ala Val Tyr Thr Ala Tyr Ser 
        115                 120                 125             


Gln Thr Gly Gln Pro Tyr Ser Leu Pro Thr Tyr Asp Leu Gly Val Met 
    130                 135                 140                 


Leu Pro Ala Ile Lys Thr Glu Ser Gly Leu Ser Gln Thr Gln Ser Pro 
145                 150                 155                 160 


Leu Gln Ser Gly Cys Leu Ser Tyr Ser Pro Gly Phe Ser Thr Pro Gln 
                165                 170                 175     


Pro Gly Gln Thr Pro Tyr Ser Tyr Gln Met Pro Gly Ser Ser Phe Ala 
            180                 185                 190         


Pro Ser Ser Thr Ile Tyr Ala Asn Asn Ser Val Ser Asn Ser Thr Asn 
        195                 200                 205             


Phe Ser Gly Ser Gln Gln Asp Tyr Pro Ser Tyr Thr Ala Phe Gly Gln 
    210                 215                 220                 


Asn Gln Tyr Ala Gln Tyr Tyr Ser Ala Ser Thr Tyr Gly Ala Tyr Met 
225                 230                 235                 240 


Thr Ser Asn Asn Thr Ala Asp Gly Thr Pro Ser Ser Thr Ser Thr Tyr 
                245                 250                 255     


Gln Leu Gln Glu Ser Leu Pro Gly Leu Thr Asn Gln Pro Gly Glu Phe 
            260                 265                 270         


Asp Thr Met Gln Ser Pro Ser Thr Pro Ile Lys Asp Leu Asp Glu Arg 
        275                 280                 285             


Thr Cys Arg Ser Ser Gly Ser Lys Ser Arg Gly Arg Gly Arg Lys Asn 
    290                 295                 300                 


Asn Pro Ser Pro Pro Pro Asp Ser Asp Leu Glu Arg Val Phe Val Trp 
305                 310                 315                 320 


Asp Leu Asp Glu Thr Ile Ile Val Phe His Ser Leu Leu Thr Gly Ser 
                325                 330                 335     


Tyr Ala Gln Lys Tyr Gly Lys Asp Pro Pro Met Ala Val Thr Leu Gly 
            340                 345                 350         


Leu Arg Met Glu Glu Met Ile Phe Asn Leu Ala Asp Thr His Leu Phe 
        355                 360                 365             


Phe Asn Asp Leu Glu Glu Cys Asp Gln Val His Ile Asp Asp Val Ser 
    370                 375                 380                 


Ser Asp Asp Asn Gly Gln Asp Leu Ser Thr Tyr Ser Phe Ala Thr Asp 
385                 390                 395                 400 


Gly Phe His Ala Ala Ala Ser Ser Ala Asn Leu Cys Leu Pro Thr Gly 
                405                 410                 415     


Val Arg Gly Gly Val Asp Trp Met Arg Lys Leu Ala Phe Arg Tyr Arg 
            420                 425                 430         


Arg Val Lys Glu Leu Tyr Asn Thr Tyr Lys Asn Asn Val Gly Gly Leu 
        435                 440                 445             


Leu Gly Pro Ala Lys Arg Asp Ala Trp Leu Gln Leu Arg Ala Glu Ile 
    450                 455                 460                 


Glu Gly Leu Thr Asp Ser Trp Leu Thr Asn Ala Leu Lys Ser Leu Ser 
465                 470                 475                 480 


Ile Ile Ser Thr Arg Ser Asn Cys Ile Asn Val Leu Val Thr Thr Thr 
                485                 490                 495     


Gln Leu Ile Pro Ala Leu Ala Lys Val Leu Leu Tyr Ser Leu Gly Gly 
            500                 505                 510         


Ala Phe Pro Ile Glu Asn Ile Tyr Ser Ala Thr Lys Ile Gly Lys Glu 
        515                 520                 525             


Ser Cys Phe Glu Arg Ile Val Ser Arg Phe Gly Thr Asn Ile Thr Tyr 
    530                 535                 540                 


Val Val Ile Gly Asp Gly Arg Asp Glu Glu His Ala Ala Asn Gln His 
545                 550                 555                 560 


Asn Met Pro Phe Trp Arg Ile Ser Ser His Ser Asp Leu Leu Ala Leu 
                565                 570                 575     


His Gln Ala Leu Glu Leu Glu Tyr Leu 
            580                 585 


<210> 22
<211> 5393
<212> DNA
<213> Homo sapiens

<400> 22
tccggagttt tggctcctct cctttcctcc tccccctcgg agccggcttc tccctccgcc       60

ccgcttctcc cccgcttgtg tacgctattt gttgtggggt ggccgaaggg gatgtcctgt      120

tttcaccaga ggcacagcgc gaaggggaaa cttcgacact ggaaggaacg agaataaata      180

cttaattacg gacgcactga accgcggctg ggacagacac ttcgggaacc cgaggcggac      240

cgggcgacga gatagtcatt tttacttgaa ggaagctgct tctacttggg agtggcagga      300

gaagtgagaa aaccacatgg aagactccca ggatttaaat gaacaatcag taaagaaaac      360

gtgcacagaa tcagatgttt cacaatctca gaattccagg tctatggaaa tgcaggacct      420

agcaagtcct catactcttg ttggaggtgg tgatactcca ggtagctcca aactggaaaa      480

atctaatctc agcagcacat cagttactac aaatgggaca ggagtaatta caagtagtgg      540

ctacagcccc agatcagcac atcagtattc cccacagctg tatccttcca agccctatcc      600

acacattctt tctacaccag cagctcaaac aatgtctgcc tatgcaggcc agactcagta      660

ttcggggatg cagcagccag ccgtctacac agcctactca cagacaggac agccctacag      720

cttgcccact tacgatttgg gtgtgatgtt gccagccatc aagacagaga gtggactttc      780

ccaaactcag tccccattac agagtggctg cctcagttac agcccagggt tctctacccc      840

acagccaggc cagacacctt attcttacca aatgccaggt tctagttttg caccatcatc      900

tactatttat gcaaataatt cagtttccaa ttcaacgaat ttcagtggtt cacaacagga      960

ttatccatcc tatacagcct ttggccaaaa ccagtatgca cagtattatt cagcatcaac     1020

gtatggagcg tatatgacat cgaataacac agccgatggc acaccctctt caacctctac     1080

ttatcagttg caggaatctc tcccaggact gactaaccaa ccaggagagt tcgataccat     1140

gcagagtccc tccacaccca tcaaagatct tgatgagaga acctgtagga gttctgggtc     1200

aaagtccaga ggaagaggcc ggaaaaataa tccctccccg cctcctgata gtgacctgga     1260

gcgtgtgttt gtctgggatt tggatgaaac catcattgtt tttcactcac tgctcaccgg     1320

gtcttatgca cagaagtatg gcaaggatcc ccccatggct gtaacccttg gactccgcat     1380

ggaagaaatg atttttaatc ttgctgatac tcatttgttt tttaatgatt tagaggagtg     1440

tgatcaagtt catatagatg atgtttcctc tgatgataat gggcaggact taagtaccta     1500

cagttttgca actgatggct tccatgcagc tgcaagtagt gcaaaccttt gtttgccaac     1560

aggtgtaaga ggaggggttg actggatgag gaagttggct tttcgttaca gaagagtaaa     1620

agaattatat aacacctaca agaacaacgt tggaggactc cttggccctg ccaagaggga     1680

tgcctggcta cagttaaggg cagagattga aggtctgaca gattcctggc taacaaatgc     1740

acttaagtct ttatcaatta ttagcactag gagtaactgc ataaatgtct tggtaacgac     1800

aactcaactg atcccagcac ttgcgaaggt tctactctat agtttaggag gtgctttccc     1860

cattgagaat atttacagtg caactaaaat aggcaaggaa agctgttttg agcgtatagt     1920

gtccagattt ggcactaaca taacttatgt tgtgattgga gatggccgag atgaggagca     1980

tgccgctaac cagcacaaca tgcccttctg gaggatatcc agtcactcag acctcctggc     2040

tctccaccaa gcactggaat tagagtattt gtaactgtgt tctttagccg gagatccatt     2100

ttttatattt caagtacact gaatttttat gtgtgattca atgcctctgg ctctacacat     2160

ataaattgtc ttaatggatg aaatcatatt tggaataaaa attccagaat gaagaattca     2220

gattgctgaa tggagttaaa ctttagtgct acagaaaaga aactctatgg tcttatattt     2280

acaacacttt aatgggtttt ttaaaaatct gtggaggttg ctggtacaca ccaaatgagt     2340

ccaaactgga atgagcagct ttagcaaaga actcttaccc tggcaaagca gcaacacaca     2400

tgctccgtct gacaaggtgg tcaacaacat tcctcaaaat gggagatctt ctcagccctg     2460

aggtttgaat ctgactttag cctacctaac ccagaaaatc tgaattggaa tgcactcaga     2520

ctgtataagg acagtcctat ttagacatgt aatttgtgta aattattgat gaaaataatt     2580

tactgtgact ttattagcag ctgactttca aagtggatgc aatttttctt tcttttgttg     2640

gggaggggaa tgggagggga aatgggaata taatattgtc tcttttttaa gtttggcaaa     2700

cagaatgttc atactgatgt gttgtgcctt aaagacaaga cagcatttgt gtgttacaat     2760

gtaactttgg ttaaaatctc tgtagataat gaaaaaaaac aaaaaaaaaa acctttgtga     2820

tgattcttaa catgaccaaa tttaaaagtc aagctctcag agcttaatta ccgcatcagc     2880

aagaaactga gtattttttg caataagaaa acaacaataa taaaggaaag cttgtgtttc     2940

atttgggttc ttaataattc caataattgt atgaggcaac tatttgcgca tccaaccatg     3000

agtggaaggt ttgggaaaga ctgtgggacc tttacttaga aagtgaaatg tatgtagaag     3060

tctcaagtac cccttctaca gttttactgg agaaaactaa gagccatatt catgacaact     3120

tgcacagttt tgaggttgag acttttgata tgtgtaagtt gcatagagga ggatattatc     3180

atgcaaatca tgagcaatta tcacataaac ttttttagaa tgtgccatga acatggcata     3240

aaattcacat tgagtgcaca gggcttaaaa taaagctaag tatgtttatt cccaatgcca     3300

tggcaaaaat gataatatca tcagaaatgg aaggcagttc tcccagatgg tgtctaatga     3360

aagcaatgag tctatgaaaa ttttacctag aatatcatca taaattaaat tagcaagtgc     3420

gctggatctt ggcagcgctg ctgaaatgac aacagtaaaa taatacctgg ttctccatct     3480

gaatacatca atgcaggttc tcctcgtaac agacttgcat atgtttgtta gtttctgcct     3540

gtattgtcac tgcgcaacgg atggcattca ttacaagaag agcccatcat cgttgtgttt     3600

gcatggtttt tttccttgtg tgtagcccat gttgggaaca cgatacaggt tctcctctta     3660

tttcctatga cacgatttcc cttgtggaaa tttaagactt taagaactag agtattttta     3720

tggtgtctgc acctgcagtt ctgtgtttaa aatgtcataa tgtggatcct ggagtcaggc     3780

tactagtcag tgcccctagc cagaggctgg ttcatgagtt catcaactga ggcctctgtg     3840

gcttcaataa agtctacatt ttgctcacag atcacaacat tcactgtgga aatatgattt     3900

catttcttta ggctacaaac ctgtatttct ttactgaatg ctaaggccat gtttatattg     3960

ggtagaaaga tattgagatc ccaattttgt acaagattgt gatttcatta tctaaacctt     4020

aaacttaatc ctttaaattt tgtagctttt ggctgcatct gccccaagta ctattccagg     4080

caaattaaag ttggaatacc tttaataata taaaaataat gatagtaaat cttatacttc     4140

tgttggccct tagcttgaaa atagcagtta aaaaaattta aatgttgcct tgattatcag     4200

tacttaatta tgttgtgcac taaaacctta aatatttatt actgtgaata aaaacaaatt     4260

atctttactg tatagctggt ttctttaaat gttgatagaa ttgtggcatt acatctaaat     4320

ttgtaagtct tttcatatca aacaagcaag gctttttatg ctgctaagtc tgtgggtgca     4380

gaaagaaaca ccccttggaa gggcaaagag aagccggctg gttgcatcac cccgtgcagt     4440

ttctcacaca catctctttt tctgattctg tgttcagaag aggctgccgg cataaaacct     4500

aaatgcaagg ttgacggaga acagcttgtc tggcacaaca atggtgcagg cccacgagcc     4560

agcatcacag cttggccatg ggacgttgag tatgcacaaa ctagaactct tcccttccca     4620

ccttaggaat agaaaatcct cttcctttct aatctgaaaa acgaaaactg aacaaacaca     4680

aaaccaaccc cttggcagtt cccacctcct attgacatat ggaatattgt gccttattgt     4740

aaaccagttt gaaaaatgtt ctgtaactaa agtgggtttt cggctattat gtatacagct     4800

tggtatatta ctacgaaaga taaccacctt gtgttgcacc ttaaaaatat caagaccatg     4860

taatttccat aacaaaatag gtggcctggc tatggtatta tagcatacaa ttaggacact     4920

atgcccctgc aaaattttgt aaatcaaatt cagaggcaaa aacatatttt agaatcatac     4980

agtttgcaca cgacaagtag gtaataactg tctctaaaaa tgttttctcc ttagtccgca     5040

atgagctaag attcagaata gtgtcaacag catgctccta tatgaagttg ttttttttaa     5100

agcacatttg tttatgacaa gcctacattc tcagtgaata tggcatttag tatttctttt     5160

gaaaacaaac ttaagcatca tgagccaaag ttgcactttg actcccaact acggtagcat     5220

tatggacatc tcacaatgtc aagggtttct gttatgtatt agtaaagtat agattattgg     5280

ggcctacata atttaaaaga aatgtaaatt aatattaaaa gcttgtaaaa atatgtatat     5340

ctttactatt tctcaataaa tacctttgca attgttttca tttccttcaa aaa            5393


<210> 23
<211> 964
<212> DNA
<213> Homo sapiens

<400> 23
tcttcacctg tcattttcaa ccagcctcag cctatctgct ctgtcacaat cactactaaa       60

atatgttcct aaattgcttg tttctagatc cttccttctc atatgctcag gtgaacacat      120

gggtgaaatt taatatggaa ttgaaatatg tactatgcaa gatagattcc ttaagaaatg      180

tttctctgat ttatatgaca taattgtatt ttactagttt acctgtccat ctgtaaaact      240

ttgttttgga gatttcatat attacaatgt ttaagaaata tgctataatg ttttgtatag      300

tatatttctt cgtgataacc ttatatacta ccagtcacac gtgtttgtaa aaatctaaag      360

agtacttttg gctcctacag aatgtgtgaa gttgtgaaat tgtttttttg ttttgttttg      420

ttttgttttt atgccccaaa gatgtggagg gcttcatata agagggtaga tttaatgaga      480

gagagaggga gagacagaga gaatgataaa agaagcttaa gagattattt tatcttgtca      540

acgacattgt tattgaatgt aagctgctaa acttcttaga taaagtaaaa cagtaaaaac      600

aaacacacaa aacagaacag agaatcatca gacaggctga cgaacacagt acaataaagc      660

agccagtacc gatgatcagt ggacatcaat ttgtcttttg ggctgtagca cctgctacta      720

attggtgcaa agcgctcacc agtcagtgcg tggtttagcg cactcagctg tctcctgtat      780

gtgctgcgag aagcaagata gctaattgct gttgcttcag tgccagtgaa atcaacgtgc      840

tgagctaata gcgacagata gagggcagac agattcctgc tagcagctta gtgttagttg      900

cttgtggtaa ctaaggcagg tggcatacat ctcagaacgt ggagaatgat ggtatgcttt      960

ctga                                                                   964


<210> 24
<211> 1040
<212> DNA
<213> Homo sapiens

<400> 24
tggtagcctc cctagagaca cagagctggg ccggatgagt ccaggcactg acgtgatcca       60

ttatctttca ccttaaagag taaaagggaa actaaagtta attacctcca cgaaacaaaa      120

aggtgccttc ttgtgcttca attacatgga tatattctac tagtctaaaa gtatcttctc      180

acttctttct gtcactgtga ggacttgagt cagaagaaag tttaaataca gtcattgagc      240

tggaaagagt ggaaagagaa gcaaagaggg ggaagctgta ggaaggacga agtcaccccc      300

aagatacatg gttactgctt acaccaagca agctgccttg ggaacgcttc ccccgagcag      360

ccagaatgct cagcagtgga agacacctct attcctgtag gcgagtcctg ggaagctggt      420

caatctgcaa atgccaattc ccagcagtga gctcggtcca cgtgtaaatc aagatttggg      480

gaaagagtag ggtgggtggc atggttgaca atgtcatcag ctccctcctc tgactcctgt      540

ggtcgtgccc ccatctactc tcactcagct acaccccacc ttcggatttg tgatggacgc      600

tgggtcccta gtaaccacag caagtgtctc ccccgcactt cccccttccc cacccccacc      660

cccaccccca accaccaccc cagcgatgga gcctactctg ctccaagccg ccgctaagac      720

ccggagaagc ggaatttcac tttgaaattc ccttgcctcg tgagggccgg cgctgggcat      780

gctcagtagc cgcggcgctg ctgctgggct gctgggctgg cgcggagtcc accctgccgt      840

ctccgccttg gcttctgggc gtccagaagg ccaggcattt gccgcctctg agcgcttctg      900

ttccccttac ccgcaacctc ctactgctct tcctctctcc ctctcttagg gaggttgaag      960

ctggtgctgg tttctgtcgg cgccacagac tgactgctct gcaaacccca gccgaggacc     1020

tgaatcccgg agactagaag                                                 1040


<210> 25
<211> 964
<212> DNA
<213> Homo sapiens

<400> 25
gcccagtgga attttcctag ttctttacac tagccatgta tttacctata aaatcaggag       60

aaatatgtat atatataata tattaaaaca tatatatatt taaatgggga aatatgtaac      120

aaacaaatag aaacaagggg agaaaggcat tgtatttgac aaaacacata tgttcaggtc      180

tgagaaggct cataaagaat gttgtctgct atactttgta gttgcttctg ttatcacaca      240

atcagtctgc atatacaggc gttttatata tatatttata tagactacat atatacgtat      300

attatatatg taaatatttc actgtctttg aggacggggg ccctgtcttt tttatctgtg      360

gttttgctta gatgtcctcc aacataatct taacacatag tatgctttta gaaatcgttg      420

actgaatgct aaggacgaaa aaccggtgac cagaaggcaa ccaggaaagg ctttgctgac      480

ctccggagtg gtggagttgg aggttctggg aaggcgacta gggagccagg caggggcggg      540

gtgggatggg atgtggacag cgcttttgcg gggggaaagc gtttttgctg ctggaattga      600

gcagtaggaa tgtgtcagtc acatccccac cttcccaatt cttgtcatct cggttcagga      660

aggtgaacgg tgttccgatt ccccgcggcg ggggcctgta gtgggagctc tgccccttcc      720

ccgcctctgc tgcaggcccc gcccctcgcc cggaaccccg gggcgctggc cgcggtgctg      780

aaacggcgcc ctccgcggac ggaggagggg gcggggctct cgggagccgt gagccgggaa      840

gagggagacg ggcagggcgg cgccagcagg ccctggtggg cttgggagga ggcaggagac      900

tggagacagc ctcggctaga gcggacacag gcacctggca agctttcctt gaccaaatca      960

aggt                                                                   964


<210> 26
<211> 477
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
tctagactgc agagggccct gcgtatgagt gcaagtgggt tttaggacca ggatgaggcg       60

gggtgggggt gcctacctga cgaccgaccc cgacccactg gacaagcacc caacccccat      120

tccccaaatt gcgcatcccc tatcagagag ggggagggga aacaggatgc ggcgaggcgc      180

gtgcgcactg ccagcttcag caccgcggac agtgccttcg cccccgcctg gcggcgcgcg      240

ccaccgccgc ctcagcactg aaggcgcgct gacgtcactc gccggtcccc cgcaaactcc      300

ccttcccggc caccttggtc gcgtccgcgc cgccgccggc ccagccggac cgcaccacgc      360

gaggcgcgag ataggggggc acgggcgcga ccatctgcgc tgcggcgccg gcgactcagc      420

gctgcctcag tctgcggtgg gcagcggagg agtcgtgtcg tgcctgagag cgcagtc         477


<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Thr Leu Ala Val Pro Phe Lys 
1               5           


