                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Zhao, Yangbing
       Lin, Szu Hua Sharon
       Liu, Xiaojun
       Chew, Anne
 
<120>  PROSTATE-SPECIFIC MEMBRANE ANTIGEN CARS AND METHODS THEREOF

<130>  046483-7183WO1(01880)

<150>  62/639,321
<151>  2018-03-06

<160>  236   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of at least 1

<400>  1

Gly Ser Gly Gly Ser 
1               5   


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  repeat n times, where n represents an integer of at least 1

<400>  2

Gly Gly Gly Ser 
1               


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of at least 1

<400>  3

Gly Gly Gly Gly Ser 
1               5   


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  4

Gly Gly Ser Gly 
1               


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  5

Gly Gly Ser Gly Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  6

Gly Ser Gly Ser Gly 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  7

Gly Ser Gly Gly Gly 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  8

Gly Gly Gly Ser Gly 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  9

Gly Ser Ser Ser Gly 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  10

Gly Gly Gly Gly Ser 
1               5   


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  12
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  12
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatct                       45


<210>  13
<211>  237
<212>  PRT
<213>  Mus musculus

<400>  13

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser Val Arg Ile Ser Cys 
    130                 135                 140                 


Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val Lys 
145                 150                 155                 160 


Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn 
                165                 170                 175     


Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235         


<210>  14
<211>  260
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Met Thr Gln Ser His Lys 
            20                  25                  30          


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala 
        35                  40                  45              


Ser Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln 
            100                 105                 110         


Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp 
        115                 120                 125             


Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
145                 150                 155                 160 


Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu 
                165                 170                 175     


Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys 
        195                 200                 205             


Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  15
<211>  780
<212>  DNA
<213>  Mus musculus

<400>  15
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgccaga       60

cctggatctg acattgtgat gacccagtct cacaaattca tgtccacatc agtaggagac      120

agggtcagca tcatctgtaa ggccagtcaa gatgtgggta ctgctgtaga ctggtatcaa      180

cagaaaccag gacaatctcc taaactactg atttattggg catccactcg gcacactgga      240

gtccctgatc gcttcacagg cagtggatct gggacagact tcactctcac cattactaac      300

gttcagtctg aagacttggc agattatttc tgtcagcaat ataacagcta tcctctcacg      360

ttcggtgctg ggaccatgct ggacctgaaa ggaggcggag gatctggcgg cggaggaagt      420

tctggcggag gcagcgaggt gcagctgcag cagagcggac ccgagctcgt gaagcctgga      480

acaagcgtgc ggatcagctg caagaccagc ggctacacct tcaccgagta caccatccac      540

tgggtcaagc agtcccacgg caagagcctg gagtggatcg gcaatatcaa ccccaacaac      600

ggcggcacca cctacaacca gaagttcgag gacaaggcca ccctgaccgt ggacaagagc      660

agcagcaccg cctacatgga actgcggagc ctgaccagcg aggacagcgc cgtgtactat      720

tgtgccgccg gttggaactt cgactactgg ggccagggca caaccctgac agtgtctagc      780


<210>  16
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys 
            100                 105         


<210>  17
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  17
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcatctgta aggccagtca agatgtgggt actgctgtag actggtatca acagaaacca      120

ggacaatctc ctaaactact gatttattgg gcatccactc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagac ttcactctca ccattactaa cgttcagtct      240

gaagacttgg cagattattt ctgtcagcaa tataacagct atcctctcac gttcggtgct      300

gggaccatgc tggacctgaa a                                                321


<210>  18
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  18

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Asp 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  19

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  20

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  21
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  21

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  22
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  22
gaggtgcagc tgcagcagag cggacccgag ctcgtgaagc ctggaacaag cgtgcggatc       60

agctgcaaga ccagcggcta caccttcacc gagtacacca tccactgggt caagcagtcc      120

cacggcaaga gcctggagtg gatcggcaat atcaacccca acaacggcgg caccacctac      180

aaccagaagt tcgaggacaa ggccaccctg accgtggaca agagcagcag caccgcctac      240

atggaactgc ggagcctgac cagcgaggac agcgccgtgt actattgtgc cgccggttgg      300

aacttcgact actggggcca gggcacaacc ctgacagtgt ctagc                      345


<210>  23
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His 
1               5                   10  


<210>  24
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  24

Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Asp 
    


<210>  25
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  25

Gly Trp Asn Phe Asp Tyr 
1               5       


<210>  26
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ala Val Pro Trp Gly Ser Arg Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            180                 185                 190         


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Phe Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            260                 265         


<210>  27
<211>  801
<212>  DNA
<213>  Homo sapiens

<400>  27
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc aactggtgga gtctggggga ggcgtggtcc agcctgggag gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtagctatg ctatgcactg ggtccgccag      180

gctccaggca aggggctgga gtgggtggca gttatatcat atgatggaaa caataaatac      240

tacgcagact ccgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg      300

tatctgcaaa tgaacagcct gagagctgag gacacggctg tgtattactg tgcgagagcc      360

gtcccctggg gatcgaggta ctactactac ggtatggacg tctggggcca agggaccacg      420

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgggtgg cggcggatct      480

gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      540

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaatca      600

gggaaagctc ctaagctcct gatctttgat gcctccagtt tggaaagtgg ggtcccatca      660

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      720

gaagattttg caacttatta ctgtcaacag tttaacagtt atcctctcac tttcggcgga      780

gggaccaagg tggagatcaa a                                                801


<210>  28
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  28

Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Val Pro Trp Gly Ser Arg Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  29
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  29
ccgcaggtgc aactggtgga gtctggggga ggcgtggtcc agcctgggag gtccctgaga       60

ctctcctgtg cagcctctgg attcaccttc agtagctatg ctatgcactg ggtccgccag      120

gctccaggca aggggctgga gtgggtggca gttatatcat atgatggaaa caataaatac      180

tacgcagact ccgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg      240

tatctgcaaa tgaacagcct gagagctgag gacacggctg tgtattactg tgcgagagcc      300

gtcccctggg gatcgaggta ctactactac ggtatggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  30
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Tyr Ala Met His 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  31

Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Val Pro Trp Gly Ser Arg Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  33
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  34
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  34
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaatca      120

gggaaagctc ctaagctcct gatctttgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaacagtt atcctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  35

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  36
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  38
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Ser Asp 
        115                 120                 125             


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
        195                 200                 205             


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Tyr Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys 
            260         


<210>  39
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  39
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagcttt accagtaact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tacctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgaggcaa      360

actggtttcc tctggtcctc cgatctctgg ggccgtggca ccctggtcac tgtctcctca      420

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcaggaca ttagcagtgc tttagcctgg tatcaacaga aaccagggaa agctcctaag      600

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggctat      660

ggatctggga cagatttcac tctcaccatc aacagcctgc agcctgaaga ttttgcaact      720

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag      780

atcaaa                                                                 786


<210>  40
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  40

Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser 
            20                  25                  30          


Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Ser Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  41
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  41
ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag       60

atctcctgta agggttctgg atacagcttt accagtaact ggatcggctg ggtgcgccag      120

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      180

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      240

tacctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgaggcaa      300

actggtttcc tctggtcctc cgatctctgg ggccgtggca ccctggtcac tgtctcctca      360


<210>  42
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Asn Trp Ile Gly 
1               5   


<210>  43
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  43

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Thr Gly Phe Leu Trp Ser Ser Asp Leu 
1               5                   10  


<210>  45
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Tyr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  46
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  46
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacattagc agtgctttag cctggtatca acagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gctatggatc tgggacagat ttcactctca ccatcaacag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  47
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  47

Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu 
1               5                   10      


<210>  48
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  48

Tyr Asp Ala Ser Ser Leu Glu Ser 
1               5               


<210>  49
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  49

Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   10  


<210>  50
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp 
        115                 120                 125             


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
        195                 200                 205             


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Ile Lys 
            260                 


<210>  51
<211>  792
<212>  DNA
<213>  Homo sapiens

<400>  51
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagtttt accagcaact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tacctgcagt ggaacagcct gaaggcctcg gacaccgcca tgtattactg tgcgagacaa      360

actggtttcc tctggtcctt cgatctctgg ggccgtggca ccctggtcac tgtctcctca      420

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcaggaca ttagcagtgc tttagcctgg tatcagcaga aaccggggaa agctcctaag      600

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt      660

ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact      720

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag      780

atcaaaatca aa                                                          792


<210>  52
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  52

Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser 
            20                  25                  30          


Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  53
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  53
ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag       60

atctcctgta agggttctgg atacagtttt accagcaact ggatcggctg ggtgcgccag      120

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      180

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      240

tacctgcagt ggaacagcct gaaggcctcg gacaccgcca tgtattactg tgcgagacaa      300

actggtttcc tctggtcctt cgatctctgg ggccgtggca ccctggtcac tgtctcctca      360


<210>  54
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Asn Trp Ile Gly 
1               5   


<210>  55
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  55

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Thr Gly Phe Leu Trp Ser Phe Asp Leu 
1               5                   10  


<210>  57
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  57

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys 
            100                 105                 


<210>  58
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  58
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacattagc agtgctttag cctggtatca gcagaaaccg      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa aatcaaa                                          327


<210>  59
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  59

Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  60
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  60

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  62
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ser Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ser Pro Gly Tyr Thr Ser Ser Trp Thr Ser 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                165                 170                 175     


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala 
        195                 200                 205             


Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu Phe Thr Phe 
                245                 250                 255     


Gly Pro Gly Thr Lys Val Asp Ile Lys 
            260                 265 


<210>  63
<211>  795
<212>  DNA
<213>  Homo sapiens

<400>  63
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggatca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagcttt accaactact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tatctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgagtccc      360

gggtatacca gcagttggac ttcttttgac tactggggcc agggaaccct ggtcaccgtc      420

tcctcaggtg gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaaattgtg      480

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctctcctgc      540

agggccagtc agagtgttag cagctactta gcctggtacc aacagaaacc tggccaggct      600

cccaggctcc tcatctatga tgcatccaac agggccactg gcatcccagc caggttcagt      660

ggcagtgggt ctgggacaga cttcactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcaac tggcccctat tcactttcgg ccctgggacc      780

aaagtggata tcaaa                                                       795


<210>  64
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  64

Pro Glu Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn 
            20                  25                  30          


Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Pro Gly Tyr Thr Ser Ser Trp Thr Ser Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  65
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  65
ccggaggtgc agctggtgca gtctggatca gaggtgaaaa agcccgggga gtctctgaag       60

atctcctgta agggttctgg atacagcttt accaactact ggatcggctg ggtgcgccag      120

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      180

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      240

tatctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgagtccc      300

gggtatacca gcagttggac ttcttttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  66
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  66

Thr Asn Tyr Trp 
1               


<210>  67
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  67

Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
1               5                   10                  15      


Gln Gly 
        


<210>  68
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  68

Ser Pro Gly Tyr Thr Ser Ser Trp Thr Ser 
1               5                   10  


<210>  69
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  69

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  70
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  70
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcccctatt cactttcggc      300

cctgggacca aagtggatat caaa                                             324


<210>  71
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  71

Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
1               5                   10      


<210>  72
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  72

Tyr Asp Ala Ser Asn Arg Ala Thr 
1               5               


<210>  73
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  73

Cys Gln Gln Arg Ser Asn Trp Pro Leu Phe Thr 
1               5                   10      


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  74

Asp Lys Thr His Thr 
1               5   


<210>  75
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  75

Cys Pro Pro Cys 
1               


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  76

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  77

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  78

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  79

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  80

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  81

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  82

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  83

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  84

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  85

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  86
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  86

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  87
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  87
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  88
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  88

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  89
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  89
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  90
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge and CD8 transmembrane domain

<400>  90

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  91
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge and CD8 transmembrane domain

<400>  91
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgc                                          207


<210>  92
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  92

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  93
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  93
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagacgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  94
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  94
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  95
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS(YMNM)

<400>  95

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Asn Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  96
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS(YMNM)

<400>  96
acaaaaaaga agtattcatc cagtgtgcac gaccctaacg gtgaatacat gaacatgaga       60

gcagtgaaca cagccaaaaa atccagactc acagatgtga cccta                      105


<210>  97
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain

<400>  97

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  98
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain

<400>  98
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  99
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain

<400>  99
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgacg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaac      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga cggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  100
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain

<400>  100

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  101
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain

<400>  101
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  102
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB domain and CD3 zeta domain

<400>  102

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        35                  40                  45              


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
    50                  55                  60                  


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
65                  70                  75                  80  


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                85                  90                  95      


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            100                 105                 110         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        115                 120                 125             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    130                 135                 140                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150                 


<210>  103
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB domain and CD3 zeta domain

<400>  103
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagacgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac      180

cagctctata acgagctcaa tctaggacga agagaggagt acgacgtttt ggacaagaga      240

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg      300

tacaacgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      360

gagcgccgga ggggcaaggg gcacgacggc ctttaccagg gtctcagtac agccaccaag      420

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                         462


<210>  104
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB domain and CD3 zeta domain

<400>  104
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac      180

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga      240

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg      300

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      360

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag      420

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                         462


<210>  105
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 murine PSMA-CAR

<400>  105

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Met Thr Gln Ser His Lys 
            20                  25                  30          


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Ile Cys Lys Ala 
        35                  40                  45              


Ser Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln 
            100                 105                 110         


Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Met Leu Asp 
        115                 120                 125             


Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
145                 150                 155                 160 


Thr Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu 
                165                 170                 175     


Tyr Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys 
        195                 200                 205             


Phe Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                245                 250                 255     


Thr Val Ser Ser Ala Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  106
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  J591 murine PSMA-CAR

<400>  106
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgccaga       60

cctggatctg acattgtgat gacccagtct cacaaattca tgtccacatc agtaggagac      120

agggtcagca tcatctgtaa ggccagtcaa gatgtgggta ctgctgtaga ctggtatcaa      180

cagaaaccag gacaatctcc taaactactg atttattggg catccactcg gcacactgga      240

gtccctgatc gcttcacagg cagtggatct gggacagact tcactctcac cattactaac      300

gttcagtctg aagacttggc agattatttc tgtcagcaat ataacagcta tcctctcacg      360

ttcggtgctg ggaccatgct ggacctgaaa ggaggcggag gatctggcgg cggaggaagt      420

tctggcggag gcagcgaggt gcagctgcag cagagcggac ccgagctcgt gaagcctgga      480

acaagcgtgc ggatcagctg caagaccagc ggctacacct tcaccgagta caccatccac      540

tgggtcaagc agtcccacgg caagagcctg gagtggatcg gcaatatcaa ccccaacaac      600

ggcggcacca cctacaacca gaagttcgag gacaaggcca ccctgaccgt ggacaagagc      660

agcagcaccg cctacatgga actgcggagc ctgaccagcg aggacagcgc cgtgtactat      720

tgtgccgccg gttggaactt cgactactgg ggccagggca caaccctgac agtgtctagc      780

gctagctccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagacggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgacgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaacgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgacggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210>  107
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C3 human PSMA-CAR

<400>  107

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ala Val Pro Trp Gly Ser Arg Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            180                 185                 190         


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Phe Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  108
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1C3 human PSMA-CAR

<400>  108
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc aactggtgga gtctggggga ggcgtggtcc agcctgggag gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtagctatg ctatgcactg ggtccgccag      180

gctccaggca aggggctgga gtgggtggca gttatatcat atgatggaaa caataaatac      240

tacgcagact ccgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg      300

tatctgcaaa tgaacagcct gagagctgag gacacggctg tgtattactg tgcgagagcc      360

gtcccctggg gatcgaggta ctactactac ggtatggacg tctggggcca agggaccacg      420

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgggtgg cggcggatct      480

gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      540

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaatca      600

gggaaagctc ctaagctcct gatctttgat gcctccagtt tggaaagtgg ggtcccatca      660

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      720

gaagattttg caacttatta ctgtcaacag tttaacagtt atcctctcac tttcggcgga      780

gggaccaagg tggagatcaa aaccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagacggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gacgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caacgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgacggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc                                      1470


<210>  109
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A10 human PSMA-CAR

<400>  109

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Ser Asp 
        115                 120                 125             


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
        195                 200                 205             


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Tyr Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  110
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A10 human PSMA-CAR

<400>  110
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagcttt accagtaact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tacctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgaggcaa      360

actggtttcc tctggtcctc cgatctctgg ggccgtggca ccctggtcac tgtctcctca      420

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcaggaca ttagcagtgc tttagcctgg tatcaacaga aaccagggaa agctcctaag      600

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggctat      660

ggatctggga cagatttcac tctcaccatc aacagcctgc agcctgaaga ttttgcaact      720

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag      780

atcaaaacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      840

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      900

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc      960

cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat     1020

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga cggctgtagc     1080

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1140

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     1200

cgaagagagg agtacgacgt tttggacaag agacgtggcc gggaccctga gatgggggga     1260

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaacg aactgcagaa agataagatg     1320

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgac     1380

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1440

gccctgcccc ctcgc                                                      1455


<210>  111
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F5 human PSMA-CAR

<400>  111

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp 
        115                 120                 125             


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
        195                 200                 205             


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  112
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F5 human PSMA-CAR

<400>  112
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagtttt accagcaact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tacctgcagt ggaacagcct gaaggcctcg gacaccgcca tgtattactg tgcgagacaa      360

actggtttcc tctggtcctt cgatctctgg ggccgtggca ccctggtcac tgtctcctca      420

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcaggaca ttagcagtgc tttagcctgg tatcagcaga aaccggggaa agctcctaag      600

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt      660

ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact      720

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag      780

atcaaaatca aaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagacggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgacgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaacgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgacggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210>  113
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C6 human PSMA-CAR

<400>  113

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ser Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ser Pro Gly Tyr Thr Ser Ser Trp Thr Ser 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                165                 170                 175     


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala 
        195                 200                 205             


Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu Phe Thr Phe 
                245                 250                 255     


Gly Pro Gly Thr Lys Val Asp Ile Lys Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  114
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C6 human PSMA-CAR

<400>  114
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggatca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagcttt accaactact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tatctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgagtccc      360

gggtatacca gcagttggac ttcttttgac tactggggcc agggaaccct ggtcaccgtc      420

tcctcaggtg gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaaattgtg      480

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctctcctgc      540

agggccagtc agagtgttag cagctactta gcctggtacc aacagaaacc tggccaggct      600

cccaggctcc tcatctatga tgcatccaac agggccactg gcatcccagc caggttcagt      660

ggcagtgggt ctgggacaga cttcactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcaac tggcccctat tcactttcgg ccctgggacc      780

aaagtggata tcaaaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1020

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagac     1080

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgacgtt ttggacaaga gacgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaacga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgacg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgc                                            1464


<210>  115
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFBRII-DN

<400>  115

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Ser Gly 
        195                 200     


<210>  116
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBRII-DN

<400>  116
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcatcc      600

gga                                                                    603


<210>  117
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1-CTM-CD28 switch receptor

<400>  117

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Phe Trp Val Leu Val Val 
                165                 170                 175     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            180                 185                 190         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        195                 200                 205             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    210                 215                 220                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 235             


<210>  118
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-CTM-CD28 switch receptor

<400>  118
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctcc            714


<210>  119
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1-PTM-CD28 switch receptor

<400>  119

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Arg 
            180                 185                 190         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        195                 200                 205             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    210                 215                 220                 


Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230         


<210>  120
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-PTM-CD28 switch receptor

<400>  120
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgctcc                                696


<210>  121
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1A132L-PTM-CD28 switch receptor

<400>  121

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Arg 
            180                 185                 190         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        195                 200                 205             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    210                 215                 220                 


Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230         


<210>  122
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-PTM-CD28 switch receptor

<400>  122
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgc                                   693


<210>  123
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFBR-IL12RB1 receptor

<400>  123

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr Pro 
145                 150                 155                 160 


Cys Ala Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp Gln 
                165                 170                 175     


Trp Ile Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu Ala 
            180                 185                 190         


Leu Val Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu 
        195                 200                 205             


Glu Lys Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr 
    210                 215                 220                 


Glu Leu Ser Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met 
225                 230                 235             


<210>  124
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBR-IL12RB1 receptor

<400>  124
atggaggcgg cggtcgctgc tccgcgtccc cggctgctcc tcctcgtgct ggcggcggcg       60

gcggcggcgg cggcggcgct gctcccgggg gcgacggcgt tacagtgttt ctgccacctc      120

tgtacaaaag acaattttac ttgtgtgaca gatgggctct gctttgtctc tgtcacagag      180

accacagaca aagttataca caacagcatg tgtatagctg aaattgactt aattcctcga      240

gataggccgt ttgtatgtgc accctcttca aaaactgggt ctgtgactac aacatattgc      300

tgcaatcagg accattgcaa taaaatagaa cttccaacta ctgtaaagtc atcacctggc      360

cttggtcctg tggaactggc agctgtcatt gctggaccag tgtgcttcgt ctgcatctca      420

ctcatgttga tggtctatat cagggccgca cggcacctgt gcccgccgct gcccacaccc      480

tgtgccagct ccgccattga gttccctgga gggaaggaga cttggcagtg gatcaaccca      540

gtggacttcc aggaagaggc atccctgcag gaggccctgg tggtagagat gtcctgggac      600

aaaggcgaga ggactgagcc tctcgagaag acagagctac ctgagggtgc ccctgagctg      660

gccctggata cagagttgtc cttggaggat ggagacaggt gcaaggccaa gatg            714


<210>  125
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFBR-IL12RB2 receptor

<400>  125

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Gln Gln Lys Val Phe 
            180                 185                 190         


Val Leu Leu Ala Ala Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro 
        195                 200                 205             


Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu 
    210                 215                 220                 


Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro 
225                 230                 235                 240 


Glu Asp Pro Glu Pro Leu Val Ile Ser Glu Val Leu His Gln Val Thr 
                245                 250                 255     


Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys 
            260                 265                 270         


Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp Met Met His Ser Ala 
        275                 280                 285             


Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu 
    290                 295                 300                 


Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro 
305                 310                 315                 320 


Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro 
                325                 330                 335     


Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His 
            340                 345                 350         


Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile 
        355                 360                 365             


Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser 
    370                 375                 380                 


Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser 
385                 390                 395                 400 


Leu Met Leu 
            


<210>  126
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBR-IL12RB2 receptor

<400>  126
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ccagcaaaag gtgtttgttc tcctagcagc cctcagacct      600

cagtggtgta gcagagaaat tccagatcca gcaaatagca cttgcgctaa gaaatatccc      660

attgcagagg agaagacaca gctgcccttg gacaggctcc tgatagactg gcccacgcct      720

gaagatcctg aaccgctggt catcagtgaa gtccttcatc aagtgacccc agttttcaga      780

catcccccct gctccaactg gccacaaagg gaaaaaggaa tccaaggtca tcaggcctct      840

gagaaagaca tgatgcacag tgcctcaagc ccaccacctc caagagctct ccaagctgag      900

agcagacaac tggtggatct gtacaaggtg ctggagagca ggggctccga cccaaagcca      960

gaaaacccag cctgtccctg gacggtgctc ccagcaggtg accttcccac ccatgatggc     1020

tacttaccct ccaacataga tgacctcccc tcacatgagg cacctctcgc tgactctctg     1080

gaagaactgg agcctcagca catctccctt tctgttttcc cctcaagttc tcttcaccca     1140

ctcaccttct cctgtggtga taagctgact ctggatcagt taaagatgag gtgtgactcc     1200

ctcatgctc                                                             1209


<210>  127
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28 receptor

<400>  127

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Phe Trp Val Leu Val Val Val Gly 
        195                 200                 205             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    210                 215                 220                 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
225                 230                 235                 240 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                245                 250                 255     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            260                 265             


<210>  128
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28 receptor

<400>  128
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cgaatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgac ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag gttggccaat gacttacggg actccggagc aaccatcaga      600

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttact agtaacagtg      660

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      720

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      780

cgcgacttcg cagcctatcg ctcc                                             804


<210>  129
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13G4-1211 PD-L1/CD28 bispecific antibody

<400>  129

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser 
            100                 105                 110         


Tyr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr 
145                 150                 155                 160 


Phe Asp Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Gly Ile Ser Trp Asn Arg Gly Arg Ile Glu Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Leu Tyr Tyr Cys Ala Lys Gly Arg Phe Arg Tyr Phe Asp Trp Phe Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu 
305                 310                 315                 320 


Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr 
                325                 330                 335     


Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr 
            340                 345                 350         


Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp 
        355                 360                 365             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met Asp Asp Ile Gln 
385                 390                 395                 400 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                405                 410                 415     


Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp 
            420                 425                 430         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala 
        435                 440                 445             


Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
465                 470                 475                 480 


Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly 
                485                 490                 495     


Gly Gly Thr Lys Val Glu Ile 
            500             


<210>  130
<211>  1508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13G4-1211 PD-L1/CD28 bispecific antibody

<400>  130
atggggtggt cgtgtatcat cctgttcctg gtcgcgacag caaccggcgt gcattcggcc       60

atacagctga cccagagccc ctcctccctc tccgcttccg tgggggaccg cgtgacaatc      120

acgtgccgcg ccagccaggg aatctcctcg gccctcgcct ggtaccagca gaaacccggg      180

aaggctccca agctgctcat ctacgatgcc tcctcgcttg agtcgggcgt gccatccagg      240

ttctccggat ccgggtccgg aaccgacttt acactcacga tttcctctct gcagcccgag      300

gacttcgcca catactactg tcagcagttc aactcctacc cattcacctt cggcccgggc      360

accaaggtgg acatcaagtc tggcggggga ggctccgaag tccagctcgt ggaatccggg      420

ggcggtctcg tgcagccagg ccggagtctg cgcctgtctt gcgctgcctc ggggatcact      480

ttcgacgact acggcatgca ttgggttcgc caggccccag ggaaggggtt ggagtgggtc      540

agtggcattt catggaacag ggggcgcatc gaatacgccg actccgttaa gggcagattc      600

accatctcgc gcgataacgc caaaaacagt ctctacctcc agatgaactc gcttcgagca      660

gaggatactg ccctgtacta ttgcgcgaag ggacgcttcc gctactttga ctggtttctg      720

gactactggg gccaggggac actggtgacg gtgtcgtcgg ggggcggggg gagtcaggtg      780

cagctggtgc agtccggagc cgaggtaaag aagccaggcg cttccgtcaa ggtgtcatgc      840

aaggcctcag gctacacctt cacaagctat tacatccact gggtgcgcca agctcccggt      900

cagggcttgg agtggatcgg gtgcatttac ccagggaacg tcaacacaaa ctacaacgag      960

aagttcaagg atcgggcaac cctgaccgtg gacacatcca tctctaccgc ctacatggag     1020

ctgtcacgcc tgcgctctga tgacaccgca gtgtacttct gtaccaggag tcactacggc     1080

ctggactgga actttgatgt ctggggccag ggaaccaccg tgacggtgtc cagtgtggag     1140

ggcggtagtg gcggctctgg tgggtccgga ggctcaggcg gcgtgatgga tgacattcag     1200

atgacccaga gtccctcctc cctctccgct tccgtcggag accgcgtgac catcacttgt     1260

cacgcctcac agaatatcta cgtgtggctg aactggtacc aacagaagcc cggcaaggcc     1320

cccaagctgc ttatctataa agcgtccaac ctccacacgg gagtcccttc ccgcttctcc     1380

ggatccggca gtgggacgga cttcacactc acaatctcgt cgctgcagcc agaggacttt     1440

gcgacgtact actgccagca gggccagacc tacccatata ctttcggcgg cgggaccaag     1500

gtggagat                                                              1508


<210>  131
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A5-1412 PD-L1/CD28 bispecific antibody

<400>  131

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys 
    50                  55                  60                  


Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Ser Tyr Asp Val His Trp Val Arg Gln Ala Pro Gly Gln Arg 
                165                 170                 175     


Leu Glu Trp Met Gly Trp Leu His Ala Asp Thr Gly Ile Thr Lys Phe 
            180                 185                 190         


Ser Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala 
        195                 200                 205             


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Glu Arg Ile Gln Leu Trp Phe Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln 
                245                 250                 255     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr 
        275                 280                 285             


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys 
305                 310                 315                 320 


Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr Met 
                325                 330                 335     


Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr 
            340                 345                 350         


Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Val Met Asp Asp Ile Gln Met Thr Gln 
385                 390                 395                 400 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                405                 410                 415     


Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu 
        435                 440                 445             


His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Val Glu Ile 
            500 


<210>  132
<211>  1499
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10A5-1412 PD-L1/CD28 bispecific antibody

<400>  132
atgggctgga gttgcatcat tctcttcctc gtggcgaccg caacaggggt gcactccgac       60

atccagatga cccagtcccc gagttccctg tctgcttccg tgggagatcg cgtgactatc      120

acctgccggg cttcccaggg catctcttcc tggctggcgt ggtaccagca gaaaccagaa      180

aaggctccta agtccctgat ctacgcagct tcgtccctcc aatccggcgt cccctctcgc      240

ttctccggct ccggatccgg caccgacttc acgctgacaa tctcgagttt gcagcccgag      300

gacttcgcca cctactactg ccagcagtac aactcctacc cttacacctt cggccagggc      360

acaaagctcg aaatcaagtc gggggggggc gggtcgcagg tccagctggt gcagtccggc      420

gccgaagtca agaagcccgg agcaagtgtg aaagtgtcgt gcaaggcaag tgggtatacc      480

ttcacctcat acgacgtaca ctgggtgcgc caggcgcccg gtcagcgcct tgagtggatg      540

ggctggctcc acgccgacac cggcattacc aagttctctc agaagttcca gggaagagtg      600

accataacac gcgacaccag tgcttccaca gcttacatgg aactttcgag tctgagatcc      660

gaggacacag ccgtgtatta ctgtgcccgt gagcgcatcc agctgtggtt cgactactgg      720

gggcagggca ccctcgtgac ggtgtcgtcg gggggcgggg ggagtcaggt gcagctggtg      780

cagtccggag ccgaggtaaa gaagccaggc gcttccgtca aggtgtcatg caaggcctca      840

ggctacacct tcacaagcta ttacatccac tgggtgcgcc aagctcccgg tcagggcttg      900

gagtggatcg ggtgcattta cccagggaac gtcaacacaa actacaacga gaagttcaag      960

gatcgggcaa ccctgaccgt ggacacatcc atctctaccg cctacatgga gctgtcacgc     1020

ctgcgctctg atgacaccgc agtgtacttc tgtaccagga gtcactacgg cctggactgg     1080

aactttgatg tctggggcca gggaaccacc gtgacggtgt ccagtgtgga gggcggtagt     1140

ggcggctctg gtgggtccgg aggctcaggc ggcgtgatgg atgacattca gatgacccag     1200

agtccctcct ccctctccgc ttccgtcgga gaccgcgtga ccatcacttg tcacgcctca     1260

cagaatatct acgtgtggct gaactggtac caacagaagc ccggcaaggc ccccaagctg     1320

cttatctata aagcgtccaa cctccacacg ggagtccctt cccgcttctc cggatccggc     1380

agtgggacgg acttcacact cacaatctcg tcgctgcagc cagaggactt tgcgacgtac     1440

tactgccagc agggccagac ctacccatat actttcggcg gcgggaccaa ggtggagat      1499


<210>  133
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B12-1412 PD-L1/CD28 bispecific antibody

<400>  133

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn 
            100                 105                 110         


Trp Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Phe 
145                 150                 155                 160 


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Arg Ala His Tyr Ala 
            180                 185                 190         


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Val Thr Val Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        275                 280                 285             


Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr 
305                 310                 315                 320 


Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr 
                325                 330                 335     


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            340                 345                 350         


Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn 
        355                 360                 365             


Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met 
385                 390                 395                 400 


Asp Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                405                 410                 415     


Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val 
            420                 425                 430         


Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        435                 440                 445             


Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
465                 470                 475                 480 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro 
                485                 490                 495     


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            500                 505         


<210>  134
<211>  1520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1B12-1412 PD-L1/CD28 bispecific antibody

<400>  134
atgggctgga gttgcatcat cctctttcta gtcgccacgg ccaccggcgt acactcagag       60

atcgtgctga cacagtcgcc tgcgacgctg tcgctcagtc caggggagcg cgctactctc      120

tcctgccgcg cgtcgcagag cgtgtcgtcc tacttggcct ggtaccagca gaagcctggc      180

caggctccgc gcctgctgat atacgacgcc tcgaacagag ccacgggcat ccccgcccgt      240

tttagtggct ccgggtcggg gaccgacttc actctgacaa tctcatccct cgagcccgag      300

gatttcgccg tgtactactg tcagcagcgc tcgaattggc caaccttcgg gcaggggacg      360

aaagttgaga tcaaaagcgg cggcgggggc agccaggtcc agctcgtcca gtctggcgcc      420

gaggtcaaaa agccgggctc ttcggtcaag gtctcctgca agacttccgg cgacaccttc      480

tcctcctatg ctatctcctg ggtgcggcag gccccggggc agggcctgga gtggatggga      540

ggcatcatcc caatctttgg gagggcccac tacgcccaga agttccaggg acgcgtgaca      600

atcaccgcag acgagtccac atccactgcc tacatggagt tgtcctcgct ccggtcggag      660

gatactgccg tgtacttctg cgcccggaag ttccacttcg tgtcaggctc ccccttcggg      720

atggacgtgt ggggacaagg aaccgtgacg gtgtcgtcgg ggggctcgtc ggggggcggg      780

gggagtcagg tgcagctggt gcagtccgga gccgaggtaa agaagccagg cgcttccgtc      840

aaggtgtcat gcaaggcctc aggctacacc ttcacaagct attacatcca ctgggtgcgc      900

caagctcccg gtcagggctt ggagtggatc gggtgcattt acccagggaa cgtcaacaca      960

aactacaacg agaagttcaa ggatcgggca accctgaccg tggacacatc catctctacc     1020

gcctacatgg agctgtcacg cctgcgctct gatgacaccg cagtgtactt ctgtaccagg     1080

agtcactacg gcctggactg gaactttgat gtctggggcc agggaaccac cgtgacggtg     1140

tccagtgtgg agggcggtag tggcggctct ggtgggtccg gaggctcagg cggcgtgatg     1200

gatgacattc agatgaccca gagtccctcc tccctctccg cttccgtcgg agaccgcgtg     1260

accatcactt gtcacgcctc acagaatatc tacgtgtggc tgaactggta ccaacagaag     1320

cccggcaagg cccccaagct gcttatctat aaagcgtcca acctccacac gggagtccct     1380

tcccgcttct ccggatccgg cagtgggacg gacttcacac tcacaatctc gtcgctgcag     1440

ccagaggact ttgcgacgta ctactgccag cagggccaga cctacccata tactttcggc     1500

ggcgggacca aggtggagat                                                 1520


<210>  135
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFBR-1-1412 TGFBRII/CD28 bispecific antibody

<400>  135

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn 
            100                 105                 110         


Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
145                 150                 155                 160 


Ile Ser Asn Ser Tyr Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr 
            180                 185                 190         


Tyr Asn Pro Ser Leu Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser 
        195                 200                 205             


Lys Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile 
225                 230                 235                 240 


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu 
305                 310                 315                 320 


Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr 
                325                 330                 335     


Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr 
            340                 345                 350         


Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp 
        355                 360                 365             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met Asp Asp Ile Gln 
385                 390                 395                 400 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                405                 410                 415     


Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp 
            420                 425                 430         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala 
        435                 440                 445             


Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
465                 470                 475                 480 


Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly 
                485                 490                 495     


Gly Gly Thr Lys Val Glu Ile Lys 
            500                 


<210>  136
<211>  1512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBR-1-1412 TGFBRII/CD28 bispecific antibody

<400>  136
atgggttggt cctgcatcat cctgtttctc gtggccaccg ccaccggcgt gcactccgaa       60

attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc      120

tcctgcaggg ccagtcagag tgttcgcagc tacttagcct ggtaccaaca gaaacctggc      180

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      300

gattttgcag tttattactg tcagcagcgt agcaactggc ctccgacgtt cggccaaggg      360

accaaggtgg aaatcaaaag tggagggggc ggttcacagc tgcaggtgca ggagtcgggc      420

ccaggactgg tgaagccttc ggagaccctg tccctcacct gcactgtctc tggtggctcc      480

atcagcaaca gttatttctc ctggggctgg atccgccagc ccccagggaa gggactggag      540

tggattggga gtttctatta tggtgaaaaa acctactaca acccgtccct caagagccga      600

gccaccatat ccattgacac gtccaagagc cagttctccc tgaagctgag ctctgtgacc      660

gccgcagaca cggctgtgta ttactgtccg agagggccta ctatgattcg gggagttata      720

gactcctggg gccagggaac cctggtgacg gtgtcgtcgg ggggcggggg gagtcaggtg      780

cagctggtgc agtccggagc cgaggtaaag aagccaggcg cttccgtcaa ggtgtcatgc      840

aaggcctcag gctacacctt cacaagctat tacatccact gggtgcgcca agctcccggt      900

cagggcttgg agtggatcgg gtgcatttac ccagggaacg tcaacacaaa ctacaacgag      960

aagttcaagg atcgggcaac cctgaccgtg gacacatcca tctctaccgc ctacatggag     1020

ctgtcacgcc tgcgctctga tgacaccgca gtgtacttct gtaccaggag tcactacggc     1080

ctggactgga actttgatgt ctggggccag ggaaccaccg tgacggtgtc cagtgtggag     1140

ggcggtagtg gcggctctgg tgggtccgga ggctcaggcg gcgtgatgga tgacattcag     1200

atgacccaga gtccctcctc cctctccgct tccgtcggag accgcgtgac catcacttgt     1260

cacgcctcac agaatatcta cgtgtggctg aactggtacc aacagaagcc cggcaaggcc     1320

cccaagctgc ttatctataa agcgtccaac ctccacacgg gagtcccttc ccgcttctcc     1380

ggatccggca gtgggacgga cttcacactc acaatctcgt cgctgcagcc agaggacttt     1440

gcgacgtact actgccagca gggccagacc tacccatata ctttcggcgg cgggaccaag     1500

gtggagatta ag                                                         1512


<210>  137
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFBR-3-1412 TGFBRII/CD28 bispecific antibody

<400>  137

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Arg Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn 
            100                 105                 110         


Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
145                 150                 155                 160 


Ile Ser Ser Ser Ser Tyr Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Ile Thr Tyr 
            180                 185                 190         


Tyr Ser Pro Ser Leu Lys Ser Arg Ile Ile Ile Ser Glu Asp Thr Ser 
        195                 200                 205             


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ser Gly Phe Thr Met Ile Arg Gly Ala Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu 
305                 310                 315                 320 


Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr 
                325                 330                 335     


Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr 
            340                 345                 350         


Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp 
        355                 360                 365             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Met Asp Asp Ile Gln 
385                 390                 395                 400 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                405                 410                 415     


Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp 
            420                 425                 430         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala 
        435                 440                 445             


Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
465                 470                 475                 480 


Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly 
                485                 490                 495     


Gly Gly Thr Lys Val Glu Ile Lys 
            500                 


<210>  138
<211>  1512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBR-3-1412 TGFBRII/CD28 bispecific antibody

<400>  138
atgggttggt cctgcatcat cctgtttctc gtggccaccg ccaccggcgt gcactccgaa       60

attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc      120

tcctgcaggg ccagtcagag tgttagaagt ttcttagcct ggtaccaaca gaaacctggc      180

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      300

gattttgcag tttattactg tcagcagcgt agcaactggc ctccgacgtt cggccaaggg      360

accaaggtgg aaatcaaaag tggagggggc ggttcacagc tacagctgca ggagtcgggc      420

ccaggactgg tgaagccttc ggagacccta tccctcacct gcactgtctc tggtggctcc      480

atcagcagta gtagttactc ctggggctgg atccgccagc ccccagggaa gggcctggag      540

tggattggga gtttctatta cagtgggatc acctactaca gcccgtccct caagagtcga      600

attatcatat ccgaagacac gtccaagaac cagttctccc tgaagctgag ttctgtgacc      660

gccgcagaca cggctgtgta ttactgtgcg agcgggttta ctatgattcg gggagccctt      720

gactactggg gccagggaac cctggtgacg gtgtcgtcgg ggggcggggg gagtcaggtg      780

cagctggtgc agtccggagc cgaggtaaag aagccaggcg cttccgtcaa ggtgtcatgc      840

aaggcctcag gctacacctt cacaagctat tacatccact gggtgcgcca agctcccggt      900

cagggcttgg agtggatcgg gtgcatttac ccagggaacg tcaacacaaa ctacaacgag      960

aagttcaagg atcgggcaac cctgaccgtg gacacatcca tctctaccgc ctacatggag     1020

ctgtcacgcc tgcgctctga tgacaccgca gtgtacttct gtaccaggag tcactacggc     1080

ctggactgga actttgatgt ctggggccag ggaaccaccg tgacggtgtc cagtgtggag     1140

ggcggtagtg gcggctctgg tgggtccgga ggctcaggcg gcgtgatgga tgacattcag     1200

atgacccaga gtccctcctc cctctccgct tccgtcggag accgcgtgac catcacttgt     1260

cacgcctcac agaatatcta cgtgtggctg aactggtacc aacagaagcc cggcaaggcc     1320

cccaagctgc ttatctataa agcgtccaac ctccacacgg gagtcccttc ccgcttctcc     1380

ggatccggca gtgggacgga cttcacactc acaatctcgt cgctgcagcc agaggacttt     1440

gcgacgtact actgccagca gggccagacc tacccatata ctttcggcgg cgggaccaag     1500

gtggagatta ag                                                         1512


<210>  139
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  139

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  140
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  140
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct             54


<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  141

Ser Gly Arg Ser Gly Gly Gly 
1               5           


<210>  142
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  142
tccggaagat ctggcggcgg a                                                 21


<210>  143
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A

<400>  143

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  144
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F2A

<400>  144
gtgaaacaga ctttgaattt tgaccttctc aagttggcgg gagacgtgga gtccaaccca       60

gggccg                                                                  66


<210>  145
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  furin cleavage site


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  145

Arg Xaa Lys Arg 
1               


<210>  146
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  furin cleavage site


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  146

Arg Xaa Arg Arg 
1               


<210>  147
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  furin cleavage site


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  147

Arg Xaa Xaa Arg 
1               


<210>  148
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  furin cleavage site

<400>  148

Arg Gln Lys Arg 
1               


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  furin cleavage site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  149

Xaa Arg Xaa Xaa Arg 
1               5   


<210>  150
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F-GS2-T2A linker

<400>  150
cgtgcgaaga ggggcggcgg gggctccggc gggggaggca gtgagggccg cggctccctg       60

ctgacctgcg gagatgtaga agagaaccca ggcccc                                 96


<210>  151
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F-GS2-T2A linker

<400>  151

Arg Ala Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Gly 
1               5                   10                  15      


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25                  30          


<210>  152
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFbRDN-PSMA-CAR

<400>  152
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcatcc      600

ggaagatctg gcggcggaga gggcagagga agtcttctaa catgcggtga cgtggaggag      660

aatcccggcc ctagagccac catggccctg cctgtgacag ccctgctgct gcctctggct      720

ctgctgctgc acgccgccag acctggatct gacattgtga tgacccagtc tcacaaattc      780

atgtccacat cagtaggaga cagggtcagc atcatctgta aggccagtca agatgtgggt      840

actgctgtag actggtatca acagaaacca ggacaatctc ctaaactact gatttattgg      900

gcatccactc ggcacactgg agtccctgat cgcttcacag gcagtggatc tgggacagac      960

ttcactctca ccattactaa cgttcagtct gaagacttgg cagattattt ctgtcagcaa     1020

tataacagct atcctctcac gttcggtgct gggaccatgc tggacctgaa aggaggcgga     1080

ggatctggcg gcggaggaag ttctggcgga ggcagcgagg tgcagctgca gcagagcgga     1140

cccgagctcg tgaagcctgg aacaagcgtg cggatcagct gcaagaccag cggctacacc     1200

ttcaccgagt acaccatcca ctgggtcaag cagtcccacg gcaagagcct ggagtggatc     1260

ggcaatatca accccaacaa cggcggcacc acctacaacc agaagttcga ggacaaggcc     1320

accctgaccg tggacaagag cagcagcacc gcctacatgg aactgcggag cctgaccagc     1380

gaggacagcg ccgtgtacta ttgtgccgcc ggttggaact tcgactactg gggccagggc     1440

acaaccctga cagtgtctag cgctagctcc ggaaccacga cgccagcgcc gcgaccacca     1500

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca     1560

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg     1620

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     1680

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1740

actactcaag aggaagacgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1800

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac     1860

cagctctata acgagctcaa tctaggacga agagaggagt acgacgtttt ggacaagaga     1920

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1980

tacaacgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     2040

gagcgccgga ggggcaaggg gcacgacggc ctttaccagg gtctcagtac agccaccaag     2100

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                        2142


<210>  153
<211>  2151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFbRDN-1C3PSMA-CAR

<400>  153
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcatcc      600

ggaagatctg gcggcggaga gggcagagga agtcttctaa catgcggtga cgtggaggag      660

aatcccggcc ctagagccac catggcctta ccagtgaccg ccttgctcct gccgctggcc      720

ttgctgctcc acgccgccag gccgcaggtg caactggtgg agtctggggg aggcgtggtc      780

cagcctggga ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagctat      840

gctatgcact gggtccgcca ggctccaggc aaggggctgg agtgggtggc agttatatca      900

tatgatggaa acaataaata ctacgcagac tccgtgaagg gccgattcac catctccaga      960

gacaattcca agaacacgct gtatctgcaa atgaacagcc tgagagctga ggacacggct     1020

gtgtattact gtgcgagagc cgtcccctgg ggatcgaggt actactacta cggtatggac     1080

gtctggggcc aagggaccac ggtcaccgtc tcctcaggtg gcggtggctc gggcggtggt     1140

gggtcgggtg gcggcggatc tgccatccag ttgacccagt ctccatcctc cctgtctgca     1200

tctgtaggag acagagtcac catcacttgc cgggcaagtc agggcattag cagtgcttta     1260

gcctggtatc agcagaaatc agggaaagct cctaagctcc tgatctttga tgcctccagt     1320

ttggaaagtg gggtcccatc aaggttcagc ggcagtggat ctgggacaga tttcactctc     1380

accatcagca gcctgcagcc tgaagatttt gcaacttatt actgtcaaca gtttaacagt     1440

tatcctctca ctttcggcgg agggaccaag gtggagatca aaaccacgac gccagcgccg     1500

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1560

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1620

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1680

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1740

ccagtacaaa ctactcaaga ggaagacggc tgtagctgcc gatttccaga agaagaagaa     1800

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     1860

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgacgttttg     1920

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1980

gaaggcctgt acaacgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     2040

atgaaaggcg agcgccggag gggcaagggg cacgacggcc tttaccaggg tctcagtaca     2100

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg c              2151


<210>  154
<211>  2136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFbRDN-2A10PSMA-CAR

<400>  154
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcatcc      600

ggaagatctg gcggcggaga gggcagagga agtcttctaa catgcggtga cgtggaggag      660

aatcccggcc ctagagccac catggcctta ccagtgaccg ccttgctcct gccgctggcc      720

ttgctgctcc acgccgccag gccggaggtg cagctggtgc agtctggagc agaggtgaaa      780

aagcccgggg agtctctgaa gatctcctgt aagggttctg gatacagctt taccagtaac      840

tggatcggct gggtgcgcca gatgcccggg aaaggcctgg agtggatggg gatcatctat      900

cctggtgact ctgataccag atacagcccg tccttccaag gccaggtcac catctcagcc      960

gacaagtcca tcagcaccgc ctacctgcag tggagcagcc tgaaggcctc ggacaccgcc     1020

atgtattact gtgcgaggca aactggtttc ctctggtcct ccgatctctg gggccgtggc     1080

accctggtca ctgtctcctc aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc     1140

ggatctgcca tccagttgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga     1200

gtcaccatca cttgccgggc aagtcaggac attagcagtg ctttagcctg gtatcaacag     1260

aaaccaggga aagctcctaa gctcctgatc tatgatgcct ccagtttgga aagtggggtc     1320

ccatcaaggt tcagcggcta tggatctggg acagatttca ctctcaccat caacagcctg     1380

cagcctgaag attttgcaac ttattactgt caacagttta atagttaccc gctcactttc     1440

ggcggaggga ccaaggtgga gatcaaaacc acgacgccag cgccgcgacc accaacaccg     1500

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg     1560

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc     1620

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1680

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1740

caagaggaag acggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1800

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1860

tataacgagc tcaatctagg acgaagagag gagtacgacg ttttggacaa gagacgtggc     1920

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaac     1980

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     2040

cggaggggca aggggcacga cggcctttac cagggtctca gtacagccac caaggacacc     2100

tacgacgccc ttcacatgca ggccctgccc cctcgc                               2136


<210>  155
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFbRDN-2F5PSMA-CAR

<400>  155
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcatcc      600

ggaagatctg gcggcggaga gggcagagga agtcttctaa catgcggtga cgtggaggag      660

aatcccggcc ctagagccac catggcctta ccagtgaccg ccttgctcct gccgctggcc      720

ttgctgctcc acgccgccag gccggaggtg cagctggtgc agtctggagc agaggtgaaa      780

aagcccgggg agtctctgaa gatctcctgt aagggttctg gatacagttt taccagcaac      840

tggatcggct gggtgcgcca gatgcccggg aaaggcctgg agtggatggg gatcatctat      900

cctggtgact ctgataccag atacagcccg tccttccaag gccaggtcac catctcagcc      960

gacaagtcca tcagcaccgc ctacctgcag tggaacagcc tgaaggcctc ggacaccgcc     1020

atgtattact gtgcgagaca aactggtttc ctctggtcct tcgatctctg gggccgtggc     1080

accctggtca ctgtctcctc aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc     1140

ggatctgcca tccagttgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga     1200

gtcaccatca cttgccgggc aagtcaggac attagcagtg ctttagcctg gtatcagcag     1260

aaaccgggga aagctcctaa gctcctgatc tatgatgcct ccagtttgga aagtggggtc     1320

ccatcaaggt tcagcggcag tggatctggg acagatttca ctctcaccat cagcagcctg     1380

cagcctgaag attttgcaac ttattactgt caacagttta atagttaccc gctcactttc     1440

ggcggaggga ccaaggtgga gatcaaaatc aaaaccacga cgccagcgcc gcgaccacca     1500

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca     1560

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg     1620

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     1680

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1740

actactcaag aggaagacgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1800

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac     1860

cagctctata acgagctcaa tctaggacga agagaggagt acgacgtttt ggacaagaga     1920

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1980

tacaacgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     2040

gagcgccgga ggggcaaggg gcacgacggc ctttaccagg gtctcagtac agccaccaag     2100

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                        2142


<210>  156
<211>  2145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFbRDN-2C6PSMA-CAR

<400>  156
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcatcc      600

ggaagatctg gcggcggaga gggcagagga agtcttctaa catgcggtga cgtggaggag      660

aatcccggcc ctagagccac catggcctta ccagtgaccg ccttgctcct gccgctggcc      720

ttgctgctcc acgccgccag gccggaggtg cagctggtgc agtctggatc agaggtgaaa      780

aagcccgggg agtctctgaa gatctcctgt aagggttctg gatacagctt taccaactac      840

tggatcggct gggtgcgcca gatgcccggg aaaggcctgg agtggatggg gatcatctat      900

cctggtgact ctgataccag atacagcccg tccttccaag gccaggtcac catctcagcc      960

gacaagtcca tcagcaccgc ctatctgcag tggagcagcc tgaaggcctc ggacaccgcc     1020

atgtattact gtgcgagtcc cgggtatacc agcagttgga cttcttttga ctactggggc     1080

cagggaaccc tggtcaccgt ctcctcaggt ggcggtggct cgggcggtgg tgggtcgggt     1140

ggcggcggat ctgaaattgt gttgacacag tctccagcca ccctgtcttt gtctccaggg     1200

gaaagagcca ccctctcctg cagggccagt cagagtgtta gcagctactt agcctggtac     1260

caacagaaac ctggccaggc tcccaggctc ctcatctatg atgcatccaa cagggccact     1320

ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc     1380

agcctagagc ctgaagattt tgcagtttat tactgtcagc agcgtagcaa ctggccccta     1440

ttcactttcg gccctgggac caaagtggat atcaaaacca cgacgccagc gccgcgacca     1500

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg     1560

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc     1620

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac     1680

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     1740

caaactactc aagaggaaga cggctgtagc tgccgatttc cagaagaaga agaaggagga     1800

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     1860

aaccagctct ataacgagct caatctagga cgaagagagg agtacgacgt tttggacaag     1920

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1980

ctgtacaacg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     2040

ggcgagcgcc ggaggggcaa ggggcacgac ggcctttacc agggtctcag tacagccacc     2100

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     2145


<210>  157
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-CTM-CD28-1C3PSMA-CAR

<400>  157
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccgtgaaa      720

cagactttga attttgacct tctcaagttg gcgggagacg tggagtccaa cccagggccg      780

atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg      840

ccgcaggtgc aactggtgga gtctggggga ggcgtggtcc agcctgggag gtccctgaga      900

ctctcctgtg cagcctctgg attcaccttc agtagctatg ctatgcactg ggtccgccag      960

gctccaggca aggggctgga gtgggtggca gttatatcat atgatggaaa caataaatac     1020

tacgcagact ccgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg     1080

tatctgcaaa tgaacagcct gagagctgag gacacggctg tgtattactg tgcgagagcc     1140

gtcccctggg gatcgaggta ctactactac ggtatggacg tctggggcca agggaccacg     1200

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgggtgg cggcggatct     1260

gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     1320

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaatca     1380

gggaaagctc ctaagctcct gatctttgat gcctccagtt tggaaagtgg ggtcccatca     1440

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct     1500

gaagattttg caacttatta ctgtcaacag tttaacagtt atcctctcac tttcggcgga     1560

gggaccaagg tggagatcaa aaccacgacg ccagcgccgc gaccaccaac accggcgccc     1620

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc     1680

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc     1740

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1800

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1860

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1920

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1980

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     2040

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     2100

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     2160

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     2220

gcccttcaca tgcaggccct gccccctcgc                                      2250


<210>  158
<211>  2235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-CTM-CD28-2A10PSMA-CAR

<400>  158
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccgtgaaa      720

cagactttga attttgacct tctcaagttg gcgggagacg tggagtccaa cccagggccg      780

atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg      840

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      900

atctcctgta agggttctgg atacagcttt accagtaact ggatcggctg ggtgcgccag      960

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga     1020

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc     1080

tacctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgaggcaa     1140

actggtttcc tctggtcctc cgatctctgg ggccgtggca ccctggtcac tgtctcctca     1200

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc     1260

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca     1320

agtcaggaca ttagcagtgc tttagcctgg tatcaacaga aaccagggaa agctcctaag     1380

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggctat     1440

ggatctggga cagatttcac tctcaccatc aacagcctgc agcctgaaga ttttgcaact     1500

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag     1560

atcaaaacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag     1620

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg     1680

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc     1740

cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat     1800

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1860

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1920

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     1980

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     2040

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     2100

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     2160

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     2220

gccctgcccc ctcgc                                                      2235


<210>  159
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-CTM-CD28-2F5PSMA-CAR

<400>  159
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccgtgaaa      720

cagactttga attttgacct tctcaagttg gcgggagacg tggagtccaa cccagggccg      780

atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg      840

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      900

atctcctgta agggttctgg atacagtttt accagcaact ggatcggctg ggtgcgccag      960

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga     1020

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc     1080

tacctgcagt ggaacagcct gaaggcctcg gacaccgcca tgtattactg tgcgagacaa     1140

actggtttcc tctggtcctt cgatctctgg ggccgtggca ccctggtcac tgtctcctca     1200

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc     1260

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca     1320

agtcaggaca ttagcagtgc tttagcctgg tatcagcaga aaccggggaa agctcctaag     1380

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt     1440

ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact     1500

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag     1560

atcaaaatca aaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1620

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1680

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1740

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1800

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1860

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1920

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1980

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     2040

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     2100

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     2160

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     2220

atgcaggccc tgccccctcg c                                               2241


<210>  160
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-CTM-CD28-2C6PSMA-CAR

<400>  160
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccgtgaaa      720

cagactttga attttgacct tctcaagttg gcgggagacg tggagtccaa cccagggccg      780

atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg      840

ccggaggtgc agctggtgca gtctggatca gaggtgaaaa agcccgggga gtctctgaag      900

atctcctgta agggttctgg atacagcttt accaactact ggatcggctg ggtgcgccag      960

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga     1020

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc     1080

tatctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgagtccc     1140

gggtatacca gcagttggac ttcttttgac tactggggcc agggaaccct ggtcaccgtc     1200

tcctcaggtg gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaaattgtg     1260

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctctcctgc     1320

agggccagtc agagtgttag cagctactta gcctggtacc aacagaaacc tggccaggct     1380

cccaggctcc tcatctatga tgcatccaac agggccactg gcatcccagc caggttcagt     1440

ggcagtgggt ctgggacaga cttcactctc accatcagca gcctagagcc tgaagatttt     1500

gcagtttatt actgtcagca gcgtagcaac tggcccctat tcactttcgg ccctgggacc     1560

aaagtggata tcaaaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc     1620

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg     1680

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact     1740

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     1800

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1860

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     1920

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1980

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     2040

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     2100

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     2160

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     2220

cacatgcagg ccctgccccc tcgc                                            2244


<210>  161
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-PTM-CD28-1C3PSMA-CAR

<400>  161
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgctccgtga aacagacttt gaattttgac      720

cttctcaagt tggcgggaga cgtggagtcc aacccagggc cgatggcctt accagtgacc      780

gccttgctcc tgccgctggc cttgctgctc cacgccgcca ggccgcaggt gcaactggtg      840

gagtctgggg gaggcgtggt ccagcctggg aggtccctga gactctcctg tgcagcctct      900

ggattcacct tcagtagcta tgctatgcac tgggtccgcc aggctccagg caaggggctg      960

gagtgggtgg cagttatatc atatgatgga aacaataaat actacgcaga ctccgtgaag     1020

ggccgattca ccatctccag agacaattcc aagaacacgc tgtatctgca aatgaacagc     1080

ctgagagctg aggacacggc tgtgtattac tgtgcgagag ccgtcccctg gggatcgagg     1140

tactactact acggtatgga cgtctggggc caagggacca cggtcaccgt ctcctcaggt     1200

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctgccatcca gttgacccag     1260

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt     1320

cagggcatta gcagtgcttt agcctggtat cagcagaaat cagggaaagc tcctaagctc     1380

ctgatctttg atgcctccag tttggaaagt ggggtcccat caaggttcag cggcagtgga     1440

tctgggacag atttcactct caccatcagc agcctgcagc ctgaagattt tgcaacttat     1500

tactgtcaac agtttaacag ttatcctctc actttcggcg gagggaccaa ggtggagatc     1560

aaaaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1620

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1680

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1740

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1800

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1860

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1920

gacgcccccg cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga     1980

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     2040

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     2100

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     2160

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     2220

ctgccccctc gc                                                         2232


<210>  162
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-PTM-CD28-2A10PSMA-CAR

<400>  162
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgctccgtga aacagacttt gaattttgac      720

cttctcaagt tggcgggaga cgtggagtcc aacccagggc cgatggcctt accagtgacc      780

gccttgctcc tgccgctggc cttgctgctc cacgccgcca ggccggaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccggg gagtctctga agatctcctg taagggttct      900

ggatacagct ttaccagtaa ctggatcggc tgggtgcgcc agatgcccgg gaaaggcctg      960

gagtggatgg ggatcatcta tcctggtgac tctgatacca gatacagccc gtccttccaa     1020

ggccaggtca ccatctcagc cgacaagtcc atcagcaccg cctacctgca gtggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcgaggc aaactggttt cctctggtcc     1140

tccgatctct ggggccgtgg caccctggtc actgtctcct caggtggcgg tggctcgggc     1200

ggtggtgggt cgggtggcgg cggatctgcc atccagttga cccagtctcc atcctccctg     1260

tctgcatctg taggagacag agtcaccatc acttgccggg caagtcagga cattagcagt     1320

gctttagcct ggtatcaaca gaaaccaggg aaagctccta agctcctgat ctatgatgcc     1380

tccagtttgg aaagtggggt cccatcaagg ttcagcggct atggatctgg gacagatttc     1440

actctcacca tcaacagcct gcagcctgaa gattttgcaa cttattactg tcaacagttt     1500

aatagttacc cgctcacttt cggcggaggg accaaggtgg agatcaaaac cacgacgcca     1560

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca     1620

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt     1680

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1740

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1800

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1860

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1920

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1980

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     2040

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     2100

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     2160

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc        2217


<210>  163
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-PTM-CD28-25FPSMA-CAR

<400>  163
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgctccgtga aacagacttt gaattttgac      720

cttctcaagt tggcgggaga cgtggagtcc aacccagggc cgatggcctt accagtgacc      780

gccttgctcc tgccgctggc cttgctgctc cacgccgcca ggccggaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccggg gagtctctga agatctcctg taagggttct      900

ggatacagtt ttaccagcaa ctggatcggc tgggtgcgcc agatgcccgg gaaaggcctg      960

gagtggatgg ggatcatcta tcctggtgac tctgatacca gatacagccc gtccttccaa     1020

ggccaggtca ccatctcagc cgacaagtcc atcagcaccg cctacctgca gtggaacagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcgagac aaactggttt cctctggtcc     1140

ttcgatctct ggggccgtgg caccctggtc actgtctcct caggtggcgg tggctcgggc     1200

ggtggtgggt cgggtggcgg cggatctgcc atccagttga cccagtctcc atcctccctg     1260

tctgcatctg taggagacag agtcaccatc acttgccggg caagtcagga cattagcagt     1320

gctttagcct ggtatcagca gaaaccgggg aaagctccta agctcctgat ctatgatgcc     1380

tccagtttgg aaagtggggt cccatcaagg ttcagcggca gtggatctgg gacagatttc     1440

actctcacca tcagcagcct gcagcctgaa gattttgcaa cttattactg tcaacagttt     1500

aatagttacc cgctcacttt cggcggaggg accaaggtgg agatcaaaat caaaaccacg     1560

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg     1620

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc     1680

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca     1740

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1800

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1860

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1920

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1980

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     2040

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     2100

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     2160

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     2220

cgc                                                                   2223


<210>  164
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-PTM-CD28-2C6PSMA-CAR

<400>  164
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgctccgtga aacagacttt gaattttgac      720

cttctcaagt tggcgggaga cgtggagtcc aacccagggc cgatggcctt accagtgacc      780

gccttgctcc tgccgctggc cttgctgctc cacgccgcca ggccggaggt gcagctggtg      840

cagtctggat cagaggtgaa aaagcccggg gagtctctga agatctcctg taagggttct      900

ggatacagct ttaccaacta ctggatcggc tgggtgcgcc agatgcccgg gaaaggcctg      960

gagtggatgg ggatcatcta tcctggtgac tctgatacca gatacagccc gtccttccaa     1020

ggccaggtca ccatctcagc cgacaagtcc atcagcaccg cctatctgca gtggagcagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcgagtc ccgggtatac cagcagttgg     1140

acttcttttg actactgggg ccagggaacc ctggtcaccg tctcctcagg tggcggtggc     1200

tcgggcggtg gtgggtcggg tggcggcgga tctgaaattg tgttgacaca gtctccagcc     1260

accctgtctt tgtctccagg ggaaagagcc accctctcct gcagggccag tcagagtgtt     1320

agcagctact tagcctggta ccaacagaaa cctggccagg ctcccaggct cctcatctat     1380

gatgcatcca acagggccac tggcatccca gccaggttca gtggcagtgg gtctgggaca     1440

gacttcactc tcaccatcag cagcctagag cctgaagatt ttgcagttta ttactgtcag     1500

cagcgtagca actggcccct attcactttc ggccctggga ccaaagtgga tatcaaaacc     1560

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc     1620

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac     1680

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg     1740

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     1800

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1860

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1920

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1980

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     2040

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     2100

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     2160

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     2220

cctcgc                                                                2226


<210>  165
<211>  2340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28-1C3PSMA-CAR

<400>  165
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cgaatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgac ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag gttggccaat gacttacggg actccggagc aaccatcaga      600

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttact agtaacagtg      660

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      720

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      780

cgcgacttcg cagcctatcg ctccgtgaaa cagactttga attttgacct tctcaagttg      840

gcgggagacg tggagtccaa cccagggccg atggccttac cagtgaccgc cttgctcctg      900

ccgctggcct tgctgctcca cgccgccagg ccgcaggtgc aactggtgga gtctggggga      960

ggcgtggtcc agcctgggag gtccctgaga ctctcctgtg cagcctctgg attcaccttc     1020

agtagctatg ctatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca     1080

gttatatcat atgatggaaa caataaatac tacgcagact ccgtgaaggg ccgattcacc     1140

atctccagag acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagctgag     1200

gacacggctg tgtattactg tgcgagagcc gtcccctggg gatcgaggta ctactactac     1260

ggtatggacg tctggggcca agggaccacg gtcaccgtct cctcaggtgg cggtggctcg     1320

ggcggtggtg ggtcgggtgg cggcggatct gccatccagt tgacccagtc tccatcctcc     1380

ctgtctgcat ctgtaggaga cagagtcacc atcacttgcc gggcaagtca gggcattagc     1440

agtgctttag cctggtatca gcagaaatca gggaaagctc ctaagctcct gatctttgat     1500

gcctccagtt tggaaagtgg ggtcccatca aggttcagcg gcagtggatc tgggacagat     1560

ttcactctca ccatcagcag cctgcagcct gaagattttg caacttatta ctgtcaacag     1620

tttaacagtt atcctctcac tttcggcgga gggaccaagg tggagatcaa aaccacgacg     1680

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc     1740

ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc     1800

tgtgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg     1860

gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca     1920

tttatgagac cagtacaaac tactcaagag gaagacggct gtagctgccg atttccagaa     1980

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg     2040

tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     2100

gacgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     2160

aaccctcagg aaggcctgta caacgaactg cagaaagata agatggcgga ggcctacagt     2220

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgacggcct ttaccagggt     2280

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     2340


<210>  166
<211>  2325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28-2A10PSMA-CAR

<400>  166
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cgaatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgac ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag gttggccaat gacttacggg actccggagc aaccatcaga      600

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttact agtaacagtg      660

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      720

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      780

cgcgacttcg cagcctatcg ctccgtgaaa cagactttga attttgacct tctcaagttg      840

gcgggagacg tggagtccaa cccagggccg atggccttac cagtgaccgc cttgctcctg      900

ccgctggcct tgctgctcca cgccgccagg ccggaggtgc agctggtgca gtctggagca      960

gaggtgaaaa agcccgggga gtctctgaag atctcctgta agggttctgg atacagcttt     1020

accagtaact ggatcggctg ggtgcgccag atgcccggga aaggcctgga gtggatgggg     1080

atcatctatc ctggtgactc tgataccaga tacagcccgt ccttccaagg ccaggtcacc     1140

atctcagccg acaagtccat cagcaccgcc tacctgcagt ggagcagcct gaaggcctcg     1200

gacaccgcca tgtattactg tgcgaggcaa actggtttcc tctggtcctc cgatctctgg     1260

ggccgtggca ccctggtcac tgtctcctca ggtggcggtg gctcgggcgg tggtgggtcg     1320

ggtggcggcg gatctgccat ccagttgacc cagtctccat cctccctgtc tgcatctgta     1380

ggagacagag tcaccatcac ttgccgggca agtcaggaca ttagcagtgc tttagcctgg     1440

tatcaacaga aaccagggaa agctcctaag ctcctgatct atgatgcctc cagtttggaa     1500

agtggggtcc catcaaggtt cagcggctat ggatctggga cagatttcac tctcaccatc     1560

aacagcctgc agcctgaaga ttttgcaact tattactgtc aacagtttaa tagttacccg     1620

ctcactttcg gcggagggac caaggtggag atcaaaacca cgacgccagc gccgcgacca     1680

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg     1740

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc     1800

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac     1860

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     1920

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1980

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     2040

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     2100

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     2160

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     2220

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     2280

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     2325


<210>  167
<211>  2331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28-25FPSMA-CAR

<400>  167
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cgaatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgac ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag gttggccaat gacttacggg actccggagc aaccatcaga      600

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttact agtaacagtg      660

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      720

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      780

cgcgacttcg cagcctatcg ctccgtgaaa cagactttga attttgacct tctcaagttg      840

gcgggagacg tggagtccaa cccagggccg atggccttac cagtgaccgc cttgctcctg      900

ccgctggcct tgctgctcca cgccgccagg ccggaggtgc agctggtgca gtctggagca      960

gaggtgaaaa agcccgggga gtctctgaag atctcctgta agggttctgg atacagtttt     1020

accagcaact ggatcggctg ggtgcgccag atgcccggga aaggcctgga gtggatgggg     1080

atcatctatc ctggtgactc tgataccaga tacagcccgt ccttccaagg ccaggtcacc     1140

atctcagccg acaagtccat cagcaccgcc tacctgcagt ggaacagcct gaaggcctcg     1200

gacaccgcca tgtattactg tgcgagacaa actggtttcc tctggtcctt cgatctctgg     1260

ggccgtggca ccctggtcac tgtctcctca ggtggcggtg gctcgggcgg tggtgggtcg     1320

ggtggcggcg gatctgccat ccagttgacc cagtctccat cctccctgtc tgcatctgta     1380

ggagacagag tcaccatcac ttgccgggca agtcaggaca ttagcagtgc tttagcctgg     1440

tatcagcaga aaccggggaa agctcctaag ctcctgatct atgatgcctc cagtttggaa     1500

agtggggtcc catcaaggtt cagcggcagt ggatctggga cagatttcac tctcaccatc     1560

agcagcctgc agcctgaaga ttttgcaact tattactgtc aacagtttaa tagttacccg     1620

ctcactttcg gcggagggac caaggtggag atcaaaatca aaaccacgac gccagcgccg     1680

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1740

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1800

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1860

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1920

ccagtacaaa ctactcaaga ggaagacggc tgtagctgcc gatttccaga agaagaagaa     1980

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     2040

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgacgttttg     2100

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     2160

gaaggcctgt acaacgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     2220

atgaaaggcg agcgccggag gggcaagggg cacgacggcc tttaccaggg tctcagtaca     2280

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg c              2331


<210>  168
<211>  2334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28-2C6PSMA-CAR

<400>  168
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cgaatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgac ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag gttggccaat gacttacggg actccggagc aaccatcaga      600

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttact agtaacagtg      660

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      720

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      780

cgcgacttcg cagcctatcg ctccgtgaaa cagactttga attttgacct tctcaagttg      840

gcgggagacg tggagtccaa cccagggccg atggccttac cagtgaccgc cttgctcctg      900

ccgctggcct tgctgctcca cgccgccagg ccggaggtgc agctggtgca gtctggatca      960

gaggtgaaaa agcccgggga gtctctgaag atctcctgta agggttctgg atacagcttt     1020

accaactact ggatcggctg ggtgcgccag atgcccggga aaggcctgga gtggatgggg     1080

atcatctatc ctggtgactc tgataccaga tacagcccgt ccttccaagg ccaggtcacc     1140

atctcagccg acaagtccat cagcaccgcc tatctgcagt ggagcagcct gaaggcctcg     1200

gacaccgcca tgtattactg tgcgagtccc gggtatacca gcagttggac ttcttttgac     1260

tactggggcc agggaaccct ggtcaccgtc tcctcaggtg gcggtggctc gggcggtggt     1320

gggtcgggtg gcggcggatc tgaaattgtg ttgacacagt ctccagccac cctgtctttg     1380

tctccagggg aaagagccac cctctcctgc agggccagtc agagtgttag cagctactta     1440

gcctggtacc aacagaaacc tggccaggct cccaggctcc tcatctatga tgcatccaac     1500

agggccactg gcatcccagc caggttcagt ggcagtgggt ctgggacaga cttcactctc     1560

accatcagca gcctagagcc tgaagatttt gcagtttatt actgtcagca gcgtagcaac     1620

tggcccctat tcactttcgg ccctgggacc aaagtggata tcaaaaccac gacgccagcg     1680

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag     1740

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat     1800

atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     1860

accctttact gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1920

agaccagtac aaactactca agaggaagac ggctgtagct gccgatttcc agaagaagaa     1980

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     2040

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgacgtt     2100

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     2160

caggaaggcc tgtacaacga actgcagaaa gataagatgg cggaggccta cagtgagatt     2220

gggatgaaag gcgagcgccg gaggggcaag gggcacgacg gcctttacca gggtctcagt     2280

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           2334


<210>  169
<211>  821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1C3

<400>  169
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc aactggtgga gtctggggga ggcgtggtcc agcctgggag gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtagctatg ctatgcactg ggtccgccag      180

gctccaggca aggggctgga gtgggtggca gttatatcat atgatggaaa caataaatac      240

tacgcagact ccgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg      300

tatctgcaaa tgaacagcct gagagctgag gacacggctg tgtattactg tgcgagagcc      360

gtcccctggg gatcgaggta ctactactac ggtatggacg tctggggcca agggaccacg      420

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgggtgg cggcggatct      480

gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      540

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaatca      600

gggaaagctc ctaagctcct gatctttgat gcctccagtt tggaaagtgg ggtcccatca      660

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      720

gaagattttg caacttatta ctgtcaacag tttaacagtt atcctctcac tttcggcgga      780

gggaccaagg tggagatcaa aaccacgacg ccagcgccgc g                          821


<210>  170
<211>  806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A10

<400>  170
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagcttt accagtaact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tacctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgaggcaa      360

actggtttcc tctggtcctc cgatctctgg ggccgtggca ccctggtcac tgtctcctca      420

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcaggaca ttagcagtgc tttagcctgg tatcaacaga aaccagggaa agctcctaag      600

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggctat      660

ggatctggga cagatttcac tctcaccatc aacagcctgc agcctgaaga ttttgcaact      720

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag      780

atcaaaacca cgacgccagc gccgcg                                           806


<210>  171
<211>  812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F5

<400>  171
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagtttt accagcaact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tacctgcagt ggaacagcct gaaggcctcg gacaccgcca tgtattactg tgcgagacaa      360

actggtttcc tctggtcctt cgatctctgg ggccgtggca ccctggtcac tgtctcctca      420

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcaggaca ttagcagtgc tttagcctgg tatcagcaga aaccggggaa agctcctaag      600

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt      660

ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact      720

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag      780

atcaaaatca aaaccacgac gccagcgccg cg                                    812


<210>  172
<211>  815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C6

<400>  172
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggatca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagcttt accaactact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tatctgcagt ggagcagcct gaaggcctcg gacaccgcca tgtattactg tgcgagtccc      360

gggtatacca gcagttggac ttcttttgac tactggggcc agggaaccct ggtcaccgtc      420

tcctcaggtg gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaaattgtg      480

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctctcctgc      540

agggccagtc agagtgttag cagctactta gcctggtacc aacagaaacc tggccaggct      600

cccaggctcc tcatctatga tgcatccaac agggccactg gcatcccagc caggttcagt      660

ggcagtgggt ctgggacaga cttcactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcaac tggcccctat tcactttcgg ccctgggacc      780

aaagtggata tcaaaaccac gacgccagcg ccgcg                                 815


<210>  173
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1.CD28-F2A

<400>  173
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccgtgaaa      720

cagactttga attttgacct tctcaagttg gcgggagacg tggagtccaa cccagggccg      780


<210>  174
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-PTM.CD28-F2A

<400>  174
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgctccgtga aacagacttt gaattttgac      720

cttctcaagt tggcgggaga cgtggagtcc aacccagggc cg                         762


<210>  175
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dnTGFRBII-T2A

<400>  175
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcatcc      600

ggaagatctg gcggcggaga gggcagagga agtcttctaa catgcggtga cgtggaggag      660

aatcccggcc ctagagccac c                                                681


<210>  176
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  176
aggaagtctc aaagtgccct                                                   20


<210>  177
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  177
gaacaacagc tgctccactc                                                   20


<210>  178
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  178
gctacactga gcaccaggtg gtctc                                             25


<210>  179
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  179
cccagcagtg agggtctctc tcttc                                             25


<210>  180
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  J591 PSMA scFv

<400>  180
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcatctgta aggccagtca agatgtgggt actgctgtag actggtatca acagaaacca      120

ggacaatctc ctaaactact gatttattgg gcatccactc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagac ttcactctca ccattactaa cgttcagtct      240

gaagacttgg cagattattt ctgtcagcaa tataacagct atcctctcac gttcggtgct      300

gggaccatgc tggacctgaa aggaggcgga ggatctggcg gcggaggaag ttctggcgga      360

ggcagcgagg tgcagctgca gcagagcgga cccgagctcg tgaagcctgg aacaagcgtg      420

cggatcagct gcaagaccag cggctacacc ttcaccgagt acaccatcca ctgggtcaag      480

cagtcccacg gcaagagcct ggagtggatc ggcaatatca accccaacaa cggcggcacc      540

acctacaacc agaagttcga ggacaaggcc accctgaccg tggacaagag cagcagcacc      600

gcctacatgg aactgcggag cctgaccagc gaggacagcg ccgtgtacta ttgtgccgcc      660

ggttggaact tcgactactg gggccagggc acaaccctga cagtgtctag c               711


<210>  181
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 VL

<400>  181

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  182
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 VH

<400>  182

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  183
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH consensus


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X is A or P

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  X is V or L

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  X is A or T

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  X is R or K

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  X is P or H

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  X is N or Q

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  X is V or A

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  X is I or L

<400>  183

Glu Val Gln Leu Val Gln Ser Gly Xaa Glu Xaa Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Xaa Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Xaa Gln Ala Xaa Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Xaa Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Xaa Thr Xaa Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  184
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VL consensus


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is Q or V

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X is T or F

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  X is S or T

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  X is P or S

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  X is V or D

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  X is Y or F

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  X is K or M

<400>  184

Asp Ile Xaa Met Thr Gln Ser Pro Ser Xaa Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Xaa 
65                  70                  75                  80  


Glu Asp Phe Ala Xaa Tyr Xaa Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Xaa Val Asp Ile Lys 
            100                 105         


<210>  185
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH

<400>  185

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  186
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VL

<400>  186

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Met Val Asp Ile Lys 
            100                 105         


<210>  187
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH

<400>  187

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  188
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VL

<400>  188

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  189
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH

<400>  189

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  190
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VL

<400>  190

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  191
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH

<400>  191

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  192
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VL

<400>  192

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  193
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH

<400>  193

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Gln Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  194
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH consensus


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X is A or P

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  X is V or L

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  X is A or T

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  X is R or K

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  X is P or H

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  X is N or Q

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  X is V or A

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  X is I or L

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  X is L or P

<220>
<221>  misc_feature
<222>  (98)..(102)
<223>  is AYWLF, GGWTF, or GAWTM

<400>  194

Glu Val Gln Leu Val Gln Ser Gly Xaa Glu Xaa Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Xaa Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Xaa Gln Ala Xaa Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Xaa Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Xaa Thr Xaa Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Xaa Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Xaa Xaa Xaa Xaa Xaa Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  195
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VL consensus


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is Q or V

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X is T or F

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  X is S or T

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  X is P or S

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  X is V or D

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  X is Y or F

<220>
<221>  misc_feature
<222>  (91)..(95)
<223>  is FTRYP or YNAYS

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  X is K or M

<400>  195

Asp Ile Xaa Met Thr Gln Ser Pro Ser Xaa Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Xaa 
65                  70                  75                  80  


Glu Asp Phe Ala Xaa Tyr Xaa Cys Gln Gln Xaa Xaa Xaa Xaa Xaa Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Val Asp Ile Lys 
            100                 105     


<210>  196
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH

<400>  196

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Trp Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  197
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VL

<400>  197

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  198
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH

<400>  198

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Trp Thr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  199
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VL

<400>  199

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Thr Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  200
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH

<400>  200

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ala Trp Thr Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  201
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VL

<400>  201

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ala Tyr Ser Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  202
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PSMA VH

<400>  202

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Pro Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  203
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS ICD

<400>  203

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  204
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS ICD

<400>  204
acaaaaaaga agtattcatc cagtgtgcac gaccctaacg gtgaatacat gttcatgaga       60

gcagtgaaca cagccaaaaa atccagactc acagatgtga cccta                      105


<210>  205
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS CD3zeta ICD

<400>  205

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        35                  40                  45              


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    50                  55                  60                  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
65                  70                  75                  80  


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                85                  90                  95      


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            100                 105                 110         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        115                 120                 125             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    130                 135                 140                 


Leu Pro Pro Arg 
145             


<210>  206
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS CD3zeta ICD

<400>  206
acaaaaaaga agtattcatc cagtgtgcac gaccctaacg gtgaatacat gttcatgaga       60

gcagtgaaca cagccaaaaa atccagactc acagatgtga ccctaagagt gaagttcagc      120

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat      180

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg      240

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa      300

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag      360

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt      420

cacatgcagg ccctgccccc tcgc                                             444


<210>  207
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant ICOS CD3zeta ICD

<400>  207

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Asn Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        35                  40                  45              


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    50                  55                  60                  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
65                  70                  75                  80  


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                85                  90                  95      


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            100                 105                 110         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        115                 120                 125             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    130                 135                 140                 


Leu Pro Pro Arg 
145             


<210>  208
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant ICOS CD3zeta ICD

<400>  208
acaaaaaaga agtattcatc cagtgtgcac gaccctaacg gtgaatacat gaacatgaga       60

gcagtgaaca cagccaaaaa atccagactc acagatgtga ccctaagagt gaagttcagc      120

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat      180

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg      240

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa      300

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag      360

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt      420

cacatgcagg ccctgccccc tcgc                                             444


<210>  209
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F5 human PSMA-CAR ICOS CD3z

<400>  209

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp 
        115                 120                 125             


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
        195                 200                 205             


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val 
305                 310                 315                 320 


Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys 
                325                 330                 335     


Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met 
            340                 345                 350         


Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
        355                 360                 365             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    370                 375                 380                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
385                 390                 395                 400 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                405                 410                 415     


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  210
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F5 human PSMA-CAR ICOS CD3z

<400>  210
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagtttt accagcaact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tacctgcagt ggaacagcct gaaggcctcg gacaccgcca tgtattactg tgcgagacaa      360

actggtttcc tctggtcctt cgatctctgg ggccgtggca ccctggtcac tgtctcctca      420

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcaggaca ttagcagtgc tttagcctgg tatcagcaga aaccggggaa agctcctaag      600

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt      660

ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact      720

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag      780

atcaaaatca aaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatttc tggttaccca taggatgtgc agcctttgtt      960

gtagtctgca ttttgggatg catacttatt tgttggctta caaaaaagaa gtattcatcc     1020

agtgtgcacg accctaacgg tgaatacatg ttcatgagag cagtgaacac agccaaaaaa     1080

tccagactca cagatgtgac cctaagagtg aagttcagca ggagcgcaga cgcccccgcg     1140

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1200

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  211
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2F5 human PSMA-CAR varICOS CD3z

<400>  211

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp 
        115                 120                 125             


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
        195                 200                 205             


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val 
305                 310                 315                 320 


Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys 
                325                 330                 335     


Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Asn Met 
            340                 345                 350         


Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
        355                 360                 365             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    370                 375                 380                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
385                 390                 395                 400 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                405                 410                 415     


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  212
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2F5 human PSMA-CAR varICOS CD3z

<400>  212
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      120

atctcctgta agggttctgg atacagtttt accagcaact ggatcggctg ggtgcgccag      180

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga      240

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc      300

tacctgcagt ggaacagcct gaaggcctcg gacaccgcca tgtattactg tgcgagacaa      360

actggtttcc tctggtcctt cgatctctgg ggccgtggca ccctggtcac tgtctcctca      420

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc      480

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      540

agtcaggaca ttagcagtgc tttagcctgg tatcagcaga aaccggggaa agctcctaag      600

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt      660

ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact      720

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag      780

atcaaaatca aaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatttc tggttaccca taggatgtgc agcctttgtt      960

gtagtctgca ttttgggatg catacttatt tgttggctta caaaaaagaa gtattcatcc     1020

agtgtgcacg accctaacgg tgaatacatg aacatgagag cagtgaacac agccaaaaaa     1080

tccagactca cagatgtgac cctaagagtg aagttcagca ggagcgcaga cgcccccgcg     1140

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1200

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  213
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1-4-1BB switch receptor

<400>  213

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235         


<210>  214
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-4-1BB switch receptor

<400>  214
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtt atctacatct gggcgccctt ggccgggact      540

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaaaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact g               711


<210>  215
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1A132L-4-1BB switch receptor

<400>  215

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235         


<210>  216
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-4-1BB switch receptor

<400>  216
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtt atctacatct gggcgccctt ggccgggact      540

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaaaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact g               711


<210>  217
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-CD28-F2A-2F5PSMA-CAR ICOS CD3z

<400>  217
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccgtgaaa      720

cagactttga attttgacct tctcaagttg gcgggagacg tggagtccaa cccagggccg      780

atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg      840

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      900

atctcctgta agggttctgg atacagtttt accagcaact ggatcggctg ggtgcgccag      960

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga     1020

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc     1080

tacctgcagt ggaacagcct gaaggcctcg gacaccgcca tgtattactg tgcgagacaa     1140

actggtttcc tctggtcctt cgatctctgg ggccgtggca ccctggtcac tgtctcctca     1200

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc     1260

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca     1320

agtcaggaca ttagcagtgc tttagcctgg tatcagcaga aaccggggaa agctcctaag     1380

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt     1440

ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact     1500

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag     1560

atcaaaatca aaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1620

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1680

acgagggggc tggacttcgc ctgtgatttc tggttaccca taggatgtgc agcctttgtt     1740

gtagtctgca ttttgggatg catacttatt tgttggctta caaaaaagaa gtattcatcc     1800

agtgtgcacg accctaacgg tgaatacatg ttcatgagag cagtgaacac agccaaaaaa     1860

tccagactca cagatgtgac cctaagagtg aagttcagca ggagcgcaga cgcccccgcg     1920

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1980

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg     2040

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     2100

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     2160

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     2220

cgc                                                                   2223


<210>  218
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-CD28-2F5PSMA-CAR varICOS CD3z

<400>  218
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccgtgaaa      720

cagactttga attttgacct tctcaagttg gcgggagacg tggagtccaa cccagggccg      780

atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg      840

ccggaggtgc agctggtgca gtctggagca gaggtgaaaa agcccgggga gtctctgaag      900

atctcctgta agggttctgg atacagtttt accagcaact ggatcggctg ggtgcgccag      960

atgcccggga aaggcctgga gtggatgggg atcatctatc ctggtgactc tgataccaga     1020

tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc     1080

tacctgcagt ggaacagcct gaaggcctcg gacaccgcca tgtattactg tgcgagacaa     1140

actggtttcc tctggtcctt cgatctctgg ggccgtggca ccctggtcac tgtctcctca     1200

ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgccat ccagttgacc     1260

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca     1320

agtcaggaca ttagcagtgc tttagcctgg tatcagcaga aaccggggaa agctcctaag     1380

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt     1440

ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact     1500

tattactgtc aacagtttaa tagttacccg ctcactttcg gcggagggac caaggtggag     1560

atcaaaatca aaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1620

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1680

acgagggggc tggacttcgc ctgtgatttc tggttaccca taggatgtgc agcctttgtt     1740

gtagtctgca ttttgggatg catacttatt tgttggctta caaaaaagaa gtattcatcc     1800

agtgtgcacg accctaacgg tgaatacatg aacatgagag cagtgaacac agccaaaaaa     1860

tccagactca cagatgtgac cctaagagtg aagttcagca ggagcgcaga cgcccccgcg     1920

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1980

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg     2040

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     2100

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     2160

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     2220

cgc                                                                   2223


<210>  219
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-CD28-2F5PSMA-CAR ICOS CD3z

<400>  219
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgctccgtga aacagacttt gaattttgac      720

cttctcaagt tggcgggaga cgtggagtcc aacccagggc cgatggcctt accagtgacc      780

gccttgctcc tgccgctggc cttgctgctc cacgccgcca ggccggaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccggg gagtctctga agatctcctg taagggttct      900

ggatacagtt ttaccagcaa ctggatcggc tgggtgcgcc agatgcccgg gaaaggcctg      960

gagtggatgg ggatcatcta tcctggtgac tctgatacca gatacagccc gtccttccaa     1020

ggccaggtca ccatctcagc cgacaagtcc atcagcaccg cctacctgca gtggaacagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcgagac aaactggttt cctctggtcc     1140

ttcgatctct ggggccgtgg caccctggtc actgtctcct caggtggcgg tggctcgggc     1200

ggtggtgggt cgggtggcgg cggatctgcc atccagttga cccagtctcc atcctccctg     1260

tctgcatctg taggagacag agtcaccatc acttgccggg caagtcagga cattagcagt     1320

gctttagcct ggtatcagca gaaaccgggg aaagctccta agctcctgat ctatgatgcc     1380

tccagtttgg aaagtggggt cccatcaagg ttcagcggca gtggatctgg gacagatttc     1440

actctcacca tcagcagcct gcagcctgaa gattttgcaa cttattactg tcaacagttt     1500

aatagttacc cgctcacttt cggcggaggg accaaggtgg agatcaaaat caaaaccacg     1560

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg     1620

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc     1680

gcctgtgatt tctggttacc cataggatgt gcagcctttg ttgtagtctg cattttggga     1740

tgcatactta tttgttggct tacaaaaaag aagtattcat ccagtgtgca cgaccctaac     1800

ggtgaataca tgttcatgag agcagtgaac acagccaaaa aatccagact cacagatgtg     1860

accctaagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1920

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1980

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     2040

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     2100

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     2160

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     2205


<210>  220
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-CD28-2F5PSMA-CAR varICOS CD3z

<400>  220
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atcaggagta agaggagcag gctcctgcac      600

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      660

tatgccccac cacgcgactt cgcagcctat cgctccgtga aacagacttt gaattttgac      720

cttctcaagt tggcgggaga cgtggagtcc aacccagggc cgatggcctt accagtgacc      780

gccttgctcc tgccgctggc cttgctgctc cacgccgcca ggccggaggt gcagctggtg      840

cagtctggag cagaggtgaa aaagcccggg gagtctctga agatctcctg taagggttct      900

ggatacagtt ttaccagcaa ctggatcggc tgggtgcgcc agatgcccgg gaaaggcctg      960

gagtggatgg ggatcatcta tcctggtgac tctgatacca gatacagccc gtccttccaa     1020

ggccaggtca ccatctcagc cgacaagtcc atcagcaccg cctacctgca gtggaacagc     1080

ctgaaggcct cggacaccgc catgtattac tgtgcgagac aaactggttt cctctggtcc     1140

ttcgatctct ggggccgtgg caccctggtc actgtctcct caggtggcgg tggctcgggc     1200

ggtggtgggt cgggtggcgg cggatctgcc atccagttga cccagtctcc atcctccctg     1260

tctgcatctg taggagacag agtcaccatc acttgccggg caagtcagga cattagcagt     1320

gctttagcct ggtatcagca gaaaccgggg aaagctccta agctcctgat ctatgatgcc     1380

tccagtttgg aaagtggggt cccatcaagg ttcagcggca gtggatctgg gacagatttc     1440

actctcacca tcagcagcct gcagcctgaa gattttgcaa cttattactg tcaacagttt     1500

aatagttacc cgctcacttt cggcggaggg accaaggtgg agatcaaaat caaaaccacg     1560

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg     1620

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc     1680

gcctgtgatt tctggttacc cataggatgt gcagcctttg ttgtagtctg cattttggga     1740

tgcatactta tttgttggct tacaaaaaag aagtattcat ccagtgtgca cgaccctaac     1800

ggtgaataca tgaacatgag agcagtgaac acagccaaaa aatccagact cacagatgtg     1860

accctaagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1920

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1980

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     2040

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     2100

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     2160

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     2205


<210>  221
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-41BB-2F5PSMA-CAR ICOS CD3z

<400>  221
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtt atctacatct gggcgccctt ggccgggact      540

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaaaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact ggtgaaacag      720

actttgaatt ttgaccttct caagttggcg ggagacgtgg agtccaaccc agggccgatg      780

gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc cgccaggccg      840

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc      900

tcctgtaagg gttctggata cagttttacc agcaactgga tcggctgggt gcgccagatg      960

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac     1020

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac     1080

ctgcagtgga acagcctgaa ggcctcggac accgccatgt attactgtgc gagacaaact     1140

ggtttcctct ggtccttcga tctctggggc cgtggcaccc tggtcactgt ctcctcaggt     1200

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctgccatcca gttgacccag     1260

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt     1320

caggacatta gcagtgcttt agcctggtat cagcagaaac cggggaaagc tcctaagctc     1380

ctgatctatg atgcctccag tttggaaagt ggggtcccat caaggttcag cggcagtgga     1440

tctgggacag atttcactct caccatcagc agcctgcagc ctgaagattt tgcaacttat     1500

tactgtcaac agtttaatag ttacccgctc actttcggcg gagggaccaa ggtggagatc     1560

aaaatcaaaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg     1620

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg     1680

agggggctgg acttcgcctg tgatttctgg ttacccatag gatgtgcagc ctttgttgta     1740

gtctgcattt tgggatgcat acttatttgt tggcttacaa aaaagaagta ttcatccagt     1800

gtgcacgacc ctaacggtga atacatgttc atgagagcag tgaacacagc caaaaaatcc     1860

agactcacag atgtgaccct aagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1920

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1980

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgca gagaaggaag     2040

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     2100

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     2160

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     2220


<210>  222
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-41BB-2F5PSMA-CAR varICOS CD3z

<400>  222
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtt atctacatct gggcgccctt ggccgggact      540

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaaaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact ggtgaaacag      720

actttgaatt ttgaccttct caagttggcg ggagacgtgg agtccaaccc agggccgatg      780

gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc cgccaggccg      840

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc      900

tcctgtaagg gttctggata cagttttacc agcaactgga tcggctgggt gcgccagatg      960

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac     1020

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac     1080

ctgcagtgga acagcctgaa ggcctcggac accgccatgt attactgtgc gagacaaact     1140

ggtttcctct ggtccttcga tctctggggc cgtggcaccc tggtcactgt ctcctcaggt     1200

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctgccatcca gttgacccag     1260

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt     1320

caggacatta gcagtgcttt agcctggtat cagcagaaac cggggaaagc tcctaagctc     1380

ctgatctatg atgcctccag tttggaaagt ggggtcccat caaggttcag cggcagtgga     1440

tctgggacag atttcactct caccatcagc agcctgcagc ctgaagattt tgcaacttat     1500

tactgtcaac agtttaatag ttacccgctc actttcggcg gagggaccaa ggtggagatc     1560

aaaatcaaaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg     1620

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg     1680

agggggctgg acttcgcctg tgatttctgg ttacccatag gatgtgcagc ctttgttgta     1740

gtctgcattt tgggatgcat acttatttgt tggcttacaa aaaagaagta ttcatccagt     1800

gtgcacgacc ctaacggtga atacatgaac atgagagcag tgaacacagc caaaaaatcc     1860

agactcacag atgtgaccct aagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1920

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1980

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgca gagaaggaag     2040

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     2100

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     2160

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     2220


<210>  223
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28-2F5PSMA-CAR ICOS CD3z

<400>  223
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cgaatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgac ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag gttggccaat gacttacggg actccggagc aaccatcaga      600

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttact agtaacagtg      660

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      720

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      780

cgcgacttcg cagcctatcg ctccgtgaaa cagactttga attttgacct tctcaagttg      840

gcgggagacg tggagtccaa cccagggccg atggccttac cagtgaccgc cttgctcctg      900

ccgctggcct tgctgctcca cgccgccagg ccggaggtgc agctggtgca gtctggagca      960

gaggtgaaaa agcccgggga gtctctgaag atctcctgta agggttctgg atacagtttt     1020

accagcaact ggatcggctg ggtgcgccag atgcccggga aaggcctgga gtggatgggg     1080

atcatctatc ctggtgactc tgataccaga tacagcccgt ccttccaagg ccaggtcacc     1140

atctcagccg acaagtccat cagcaccgcc tacctgcagt ggaacagcct gaaggcctcg     1200

gacaccgcca tgtattactg tgcgagacaa actggtttcc tctggtcctt cgatctctgg     1260

ggccgtggca ccctggtcac tgtctcctca ggtggcggtg gctcgggcgg tggtgggtcg     1320

ggtggcggcg gatctgccat ccagttgacc cagtctccat cctccctgtc tgcatctgta     1380

ggagacagag tcaccatcac ttgccgggca agtcaggaca ttagcagtgc tttagcctgg     1440

tatcagcaga aaccggggaa agctcctaag ctcctgatct atgatgcctc cagtttggaa     1500

agtggggtcc catcaaggtt cagcggcagt ggatctggga cagatttcac tctcaccatc     1560

agcagcctgc agcctgaaga ttttgcaact tattactgtc aacagtttaa tagttacccg     1620

ctcactttcg gcggagggac caaggtggag atcaaaatca aaaccacgac gccagcgccg     1680

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1740

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatttc     1800

tggttaccca taggatgtgc agcctttgtt gtagtctgca ttttgggatg catacttatt     1860

tgttggctta caaaaaagaa gtattcatcc agtgtgcacg accctaacgg tgaatacatg     1920

ttcatgagag cagtgaacac agccaaaaaa tccagactca cagatgtgac cctaagagtg     1980

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     2040

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     2100

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa     2160

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     2220

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     2280

gacgcccttc acatgcaggc cctgccccct cgc                                  2313


<210>  224
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28-2F5PSMA-CAR varICOS CD3z

<400>  224
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cgaatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgac ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag gttggccaat gacttacggg actccggagc aaccatcaga      600

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttact agtaacagtg      660

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      720

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      780

cgcgacttcg cagcctatcg ctccgtgaaa cagactttga attttgacct tctcaagttg      840

gcgggagacg tggagtccaa cccagggccg atggccttac cagtgaccgc cttgctcctg      900

ccgctggcct tgctgctcca cgccgccagg ccggaggtgc agctggtgca gtctggagca      960

gaggtgaaaa agcccgggga gtctctgaag atctcctgta agggttctgg atacagtttt     1020

accagcaact ggatcggctg ggtgcgccag atgcccggga aaggcctgga gtggatgggg     1080

atcatctatc ctggtgactc tgataccaga tacagcccgt ccttccaagg ccaggtcacc     1140

atctcagccg acaagtccat cagcaccgcc tacctgcagt ggaacagcct gaaggcctcg     1200

gacaccgcca tgtattactg tgcgagacaa actggtttcc tctggtcctt cgatctctgg     1260

ggccgtggca ccctggtcac tgtctcctca ggtggcggtg gctcgggcgg tggtgggtcg     1320

ggtggcggcg gatctgccat ccagttgacc cagtctccat cctccctgtc tgcatctgta     1380

ggagacagag tcaccatcac ttgccgggca agtcaggaca ttagcagtgc tttagcctgg     1440

tatcagcaga aaccggggaa agctcctaag ctcctgatct atgatgcctc cagtttggaa     1500

agtggggtcc catcaaggtt cagcggcagt ggatctggga cagatttcac tctcaccatc     1560

agcagcctgc agcctgaaga ttttgcaact tattactgtc aacagtttaa tagttacccg     1620

ctcactttcg gcggagggac caaggtggag atcaaaatca aaaccacgac gccagcgccg     1680

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1740

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatttc     1800

tggttaccca taggatgtgc agcctttgtt gtagtctgca ttttgggatg catacttatt     1860

tgttggctta caaaaaagaa gtattcatcc agtgtgcacg accctaacgg tgaatacatg     1920

aacatgagag cagtgaacac agccaaaaaa tccagactca cagatgtgac cctaagagtg     1980

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     2040

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     2100

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa     2160

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     2220

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     2280

gacgcccttc acatgcaggc cctgccccct cgc                                  2313


<210>  225
<211>  3090
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-4-1BB-TIM3-CD28-2F5PSMA-CAR ICOS CD3z

<400>  225
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtt atctacatct gggcgccctt ggccgggact      540

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaaaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact ggtgaagcag      720

acgttgaact tcgatttgct caaacttgcc ggtgacgtgg aatccaatcc ggggccgatg      780

ttttcacatc ttccctttga ctgtgtcctg ctgctgctgc tgctactact tacaaggtcc      840

tcagaagtgg aatacagagc ggaggtcggt cagaatgcct atctgccctg cttctacacc      900

ccagccgccc cagggaacct cgtgcccgtc tgctggggca aaggagcctg tcctgtgttt      960

gaatgtggca acgtggtgct caggactgat gaaagggatg tgaattattg gacatccaga     1020

tactggctaa atggggattt ccgcaaagga gatgtgtccc tgaccataga gaatgtgact     1080

ctagcagaca gtgggatcta ctgctgccga atccaaatcc caggcataat gaatgatgaa     1140

aaatttaacc tgaagttggt catcaaacca gccaaggtca cccctgcacc gactcggcag     1200

agagacttca ctgcagcctt tccaaggatg cttaccacca ggggacatgg cccagcagag     1260

acacagacac tggggagcct ccctgacata aatctaacac aaatatccac attggccaat     1320

gagttacggg actctaggtt ggccaatgac ttacgggact ccggagcaac catcagattt     1380

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttactagt aacagtggcc     1440

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1500

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1560

gacttcgcag cctatcgctc cgtgaaacag actttgaatt ttgaccttct caagttggcg     1620

ggagacgtgg agtccaaccc agggccgatg gccttaccag tgaccgcctt gctcctgccg     1680

ctggccttgc tgctccacgc cgccaggccg gaggtgcagc tggtgcagtc tggagcagag     1740

gtgaaaaagc ccggggagtc tctgaagatc tcctgtaagg gttctggata cagttttacc     1800

agcaactgga tcggctgggt gcgccagatg cccgggaaag gcctggagtg gatggggatc     1860

atctatcctg gtgactctga taccagatac agcccgtcct tccaaggcca ggtcaccatc     1920

tcagccgaca agtccatcag caccgcctac ctgcagtgga acagcctgaa ggcctcggac     1980

accgccatgt attactgtgc gagacaaact ggtttcctct ggtccttcga tctctggggc     2040

cgtggcaccc tggtcactgt ctcctcaggt ggcggtggct cgggcggtgg tgggtcgggt     2100

ggcggcggat ctgccatcca gttgacccag tctccatcct ccctgtctgc atctgtagga     2160

gacagagtca ccatcacttg ccgggcaagt caggacatta gcagtgcttt agcctggtat     2220

cagcagaaac cggggaaagc tcctaagctc ctgatctatg atgcctccag tttggaaagt     2280

ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc     2340

agcctgcagc ctgaagattt tgcaacttat tactgtcaac agtttaatag ttacccgctc     2400

actttcggcg gagggaccaa ggtggagatc aaaatcaaaa ccacgacgcc agcgccgcga     2460

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     2520

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatttctgg     2580

ttacccatag gatgtgcagc ctttgttgta gtctgcattt tgggatgcat acttatttgt     2640

tggcttacaa aaaagaagta ttcatccagt gtgcacgacc ctaacggtga atacatgttc     2700

atgagagcag tgaacacagc caaaaaatcc agactcacag atgtgaccct aagagtgaag     2760

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     2820

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     2880

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg     2940

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     3000

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     3060

gcccttcaca tgcaggccct gccccctcgc                                      3090


<210>  226
<211>  3090
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1A132L-4-1BB-TIM3-CD28-2F5PSMA-CAR varICOS CD3z

<400>  226
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtt atctacatct gggcgccctt ggccgggact      540

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaaaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact ggtgaagcag      720

acgttgaact tcgatttgct caaacttgcc ggtgacgtgg aatccaatcc ggggccgatg      780

ttttcacatc ttccctttga ctgtgtcctg ctgctgctgc tgctactact tacaaggtcc      840

tcagaagtgg aatacagagc ggaggtcggt cagaatgcct atctgccctg cttctacacc      900

ccagccgccc cagggaacct cgtgcccgtc tgctggggca aaggagcctg tcctgtgttt      960

gaatgtggca acgtggtgct caggactgat gaaagggatg tgaattattg gacatccaga     1020

tactggctaa atggggattt ccgcaaagga gatgtgtccc tgaccataga gaatgtgact     1080

ctagcagaca gtgggatcta ctgctgccga atccaaatcc caggcataat gaatgatgaa     1140

aaatttaacc tgaagttggt catcaaacca gccaaggtca cccctgcacc gactcggcag     1200

agagacttca ctgcagcctt tccaaggatg cttaccacca ggggacatgg cccagcagag     1260

acacagacac tggggagcct ccctgacata aatctaacac aaatatccac attggccaat     1320

gagttacggg actctaggtt ggccaatgac ttacgggact ccggagcaac catcagattt     1380

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttactagt aacagtggcc     1440

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1500

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1560

gacttcgcag cctatcgctc cgtgaaacag actttgaatt ttgaccttct caagttggcg     1620

ggagacgtgg agtccaaccc agggccgatg gccttaccag tgaccgcctt gctcctgccg     1680

ctggccttgc tgctccacgc cgccaggccg gaggtgcagc tggtgcagtc tggagcagag     1740

gtgaaaaagc ccggggagtc tctgaagatc tcctgtaagg gttctggata cagttttacc     1800

agcaactgga tcggctgggt gcgccagatg cccgggaaag gcctggagtg gatggggatc     1860

atctatcctg gtgactctga taccagatac agcccgtcct tccaaggcca ggtcaccatc     1920

tcagccgaca agtccatcag caccgcctac ctgcagtgga acagcctgaa ggcctcggac     1980

accgccatgt attactgtgc gagacaaact ggtttcctct ggtccttcga tctctggggc     2040

cgtggcaccc tggtcactgt ctcctcaggt ggcggtggct cgggcggtgg tgggtcgggt     2100

ggcggcggat ctgccatcca gttgacccag tctccatcct ccctgtctgc atctgtagga     2160

gacagagtca ccatcacttg ccgggcaagt caggacatta gcagtgcttt agcctggtat     2220

cagcagaaac cggggaaagc tcctaagctc ctgatctatg atgcctccag tttggaaagt     2280

ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc     2340

agcctgcagc ctgaagattt tgcaacttat tactgtcaac agtttaatag ttacccgctc     2400

actttcggcg gagggaccaa ggtggagatc aaaatcaaaa ccacgacgcc agcgccgcga     2460

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     2520

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatttctgg     2580

ttacccatag gatgtgcagc ctttgttgta gtctgcattt tgggatgcat acttatttgt     2640

tggcttacaa aaaagaagta ttcatccagt gtgcacgacc ctaacggtga atacatgaac     2700

atgagagcag tgaacacagc caaaaaatcc agactcacag atgtgaccct aagagtgaag     2760

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     2820

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     2880

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg     2940

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     3000

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     3060

gcccttcaca tgcaggccct gccccctcgc                                      3090


<210>  227
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1-CD28-2F5PSMA-CAR ICOS CD3z

<400>  227

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Phe Trp Val Leu Val Val 
                165                 170                 175     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            180                 185                 190         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        195                 200                 205             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    210                 215                 220                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys 
225                 230                 235                 240 


Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
                245                 250                 255     


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
            260                 265                 270         


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser 
        275                 280                 285             


Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys 
    290                 295                 300                 


Gly Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln 
305                 310                 315                 320 


Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp 
                325                 330                 335     


Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser 
            340                 345                 350         


Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys 
        355                 360                 365             


Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu 
    370                 375                 380                 


Trp Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                405                 410                 415     


Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu 
        435                 440                 445             


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
    450                 455                 460                 


Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
465                 470                 475                 480 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                485                 490                 495     


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
            500                 505                 510         


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro 
        515                 520                 525             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    530                 535                 540                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
545                 550                 555                 560 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys 
                565                 570                 575     


Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp 
            580                 585                 590         


Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu 
        595                 600                 605             


Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr 
    610                 615                 620                 


Asp Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
625                 630                 635                 640 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                645                 650                 655     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            660                 665                 670         


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        675                 680                 685             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    690                 695                 700                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
705                 710                 715                 720 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                725                 730                 735     


Ala Leu Pro Pro Arg 
            740     


<210>  228
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1-CD28-2F5PSMA-CAR varICOS CD3z

<400>  228

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Arg 
            180                 185                 190         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        195                 200                 205             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    210                 215                 220                 


Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Gln Thr Leu Asn Phe Asp 
225                 230                 235                 240 


Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Ala 
                245                 250                 255     


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
            260                 265                 270         


Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser 
                325                 330                 335     


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp Leu Trp 
    370                 375                 380                 


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser 
                405                 410                 415     


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
            420                 425                 430         


Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
        435                 440                 445             


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
    450                 455                 460                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
465                 470                 475                 480 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
                485                 490                 495     


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
            500                 505                 510         


Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        515                 520                 525             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    530                 535                 540                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
545                 550                 555                 560 


Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val 
                565                 570                 575     


Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr 
            580                 585                 590         


Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala 
        595                 600                 605             


Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg Val 
    610                 615                 620                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
625                 630                 635                 640 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                645                 650                 655     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
            660                 665                 670         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        675                 680                 685             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    690                 695                 700                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
705                 710                 715                 720 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730                 735 


<210>  229
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1A132L-41BB-2F5PSMA-CAR ICOS CD3z

<400>  229

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Lys Gln 
225                 230                 235                 240 


Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
                245                 250                 255     


Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala 
            260                 265                 270         


Leu Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly 
        275                 280                 285             


Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly 
    290                 295                 300                 


Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser 
                325                 330                 335     


Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala 
            340                 345                 350         


Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala 
        355                 360                 365             


Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp 
    370                 375                 380                 


Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile 
                405                 410                 415     


Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 
    450                 455                 460                 


Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
                485                 490                 495     


Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala 
        515                 520                 525             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    530                 535                 540                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
545                 550                 555                 560 


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys Ala 
                565                 570                 575     


Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu 
            580                 585                 590         


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
        595                 600                 605             


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
    610                 615                 620                 


Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
625                 630                 635                 640 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                645                 650                 655     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            660                 665                 670         


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        675                 680                 685             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    690                 695                 700                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
705                 710                 715                 720 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                725                 730                 735     


Leu Pro Pro Arg 
            740 


<210>  230
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28-2F5PSMA-CAR ICOS CD3z

<400>  230

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Phe Trp Val Leu Val Val Val Gly 
        195                 200                 205             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    210                 215                 220                 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
225                 230                 235                 240 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                245                 250                 255     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Gln Thr 
            260                 265                 270         


Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
    290                 295                 300                 


Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala 
305                 310                 315                 320 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
                325                 330                 335     


Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro 
            340                 345                 350         


Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp 
        355                 360                 365             


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
    370                 375                 380                 


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser 
385                 390                 395                 400 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser 
                405                 410                 415     


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln 
        435                 440                 445             


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    450                 455                 460                 


Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp 
465                 470                 475                 480 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala 
                485                 490                 495     


Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            500                 505                 510         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
        515                 520                 525             


Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly 
    530                 535                 540                 


Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala Pro 
545                 550                 555                 560 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                565                 570                 575     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            580                 585                 590         


Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys Ala Ala 
        595                 600                 605             


Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr 
    610                 615                 620                 


Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met 
625                 630                 635                 640 


Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val 
                645                 650                 655     


Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            660                 665                 670         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        675                 680                 685             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    690                 695                 700                 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
705                 710                 715                 720 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                725                 730                 735     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            740                 745                 750         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        755                 760                 765             


Pro Pro Arg 
    770     


<210>  231
<211>  1030
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1A132L-4-1BB-TIM3-CD28-2F5PSMA-CAR ICOS CD3z

<400>  231

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Lys Gln 
225                 230                 235                 240 


Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
                245                 250                 255     


Pro Gly Pro Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu 
            260                 265                 270         


Leu Leu Leu Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu 
        275                 280                 285             


Val Gly Gln Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro 
    290                 295                 300                 


Gly Asn Leu Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe 
305                 310                 315                 320 


Glu Cys Gly Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr 
                325                 330                 335     


Trp Thr Ser Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val 
            340                 345                 350         


Ser Leu Thr Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys 
        355                 360                 365             


Cys Arg Ile Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu 
    370                 375                 380                 


Lys Leu Val Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln 
385                 390                 395                 400 


Arg Asp Phe Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His 
                405                 410                 415     


Gly Pro Ala Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu 
            420                 425                 430         


Thr Gln Ile Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala 
        435                 440                 445             


Asn Asp Leu Arg Asp Ser Gly Ala Thr Ile Arg Phe Trp Val Leu Val 
    450                 455                 460                 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
465                 470                 475                 480 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
                485                 490                 495     


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
            500                 505                 510         


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val 
        515                 520                 525             


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
    530                 535                 540                 


Ser Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
545                 550                 555                 560 


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Val Gln 
                565                 570                 575     


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
            580                 585                 590         


Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg 
        595                 600                 605             


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly 
    610                 615                 620                 


Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile 
625                 630                 635                 640 


Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu 
                645                 650                 655     


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe 
            660                 665                 670         


Leu Trp Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    690                 695                 700                 


Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
705                 710                 715                 720 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
                725                 730                 735     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            740                 745                 750         


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
        755                 760                 765             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    770                 775                 780                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
785                 790                 795                 800 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr 
                805                 810                 815     


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            820                 825                 830         


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        835                 840                 845             


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly 
    850                 855                 860                 


Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys 
865                 870                 875                 880 


Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
                885                 890                 895     


Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
            900                 905                 910         


Thr Asp Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        915                 920                 925             


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    930                 935                 940                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
945                 950                 955                 960 


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                965                 970                 975     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            980                 985                 990         


Gly Met Lys Gly Glu Arg Arg Arg  Gly Lys Gly His Asp  Gly Leu Tyr 
        995                 1000                 1005             


Gln Gly  Leu Ser Thr Ala Thr  Lys Asp Thr Tyr Asp  Ala Leu His 
    1010                 1015                 1020             


Met Gln  Ala Leu Pro Pro Arg  
    1025                 1030 


<210>  232
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1-CD28-2F5PSMA-CAR varICOS CD3z

<400>  232

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Phe Trp Val Leu Val Val 
                165                 170                 175     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            180                 185                 190         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        195                 200                 205             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    210                 215                 220                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys 
225                 230                 235                 240 


Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
                245                 250                 255     


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
            260                 265                 270         


Ala Leu Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser 
        275                 280                 285             


Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys 
    290                 295                 300                 


Gly Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln 
305                 310                 315                 320 


Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp 
                325                 330                 335     


Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser 
            340                 345                 350         


Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys 
        355                 360                 365             


Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu 
    370                 375                 380                 


Trp Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                405                 410                 415     


Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu 
        435                 440                 445             


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
    450                 455                 460                 


Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
465                 470                 475                 480 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                485                 490                 495     


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
            500                 505                 510         


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro 
        515                 520                 525             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    530                 535                 540                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
545                 550                 555                 560 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys 
                565                 570                 575     


Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp 
            580                 585                 590         


Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu 
        595                 600                 605             


Tyr Met Asn Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr 
    610                 615                 620                 


Asp Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
625                 630                 635                 640 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                645                 650                 655     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            660                 665                 670         


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        675                 680                 685             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    690                 695                 700                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
705                 710                 715                 720 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                725                 730                 735     


Ala Leu Pro Pro Arg 
            740     


<210>  233
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1A132L-CD28-2F5PSMA-CAR ICOS CD3z

<400>  233

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Arg 
            180                 185                 190         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        195                 200                 205             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    210                 215                 220                 


Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Gln Thr Leu Asn Phe Asp 
225                 230                 235                 240 


Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Ala 
                245                 250                 255     


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
            260                 265                 270         


Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        275                 280                 285             


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
    290                 295                 300                 


Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser 
                325                 330                 335     


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp Leu Trp 
    370                 375                 380                 


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser 
                405                 410                 415     


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
            420                 425                 430         


Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
        435                 440                 445             


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
    450                 455                 460                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
465                 470                 475                 480 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
                485                 490                 495     


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
            500                 505                 510         


Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        515                 520                 525             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    530                 535                 540                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
545                 550                 555                 560 


Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val 
                565                 570                 575     


Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr 
            580                 585                 590         


Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Asn Met Arg Ala 
        595                 600                 605             


Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg Val 
    610                 615                 620                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
625                 630                 635                 640 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                645                 650                 655     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
            660                 665                 670         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        675                 680                 685             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    690                 695                 700                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
705                 710                 715                 720 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730                 735 


<210>  234
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1A132L-41BB-2F5PSMA-CAR varICOS CD3z

<400>  234

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Lys Gln 
225                 230                 235                 240 


Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
                245                 250                 255     


Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala 
            260                 265                 270         


Leu Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly 
        275                 280                 285             


Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly 
    290                 295                 300                 


Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser 
                325                 330                 335     


Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala 
            340                 345                 350         


Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala 
        355                 360                 365             


Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp 
    370                 375                 380                 


Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile 
                405                 410                 415     


Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 
    450                 455                 460                 


Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
                485                 490                 495     


Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala 
        515                 520                 525             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    530                 535                 540                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
545                 550                 555                 560 


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys Ala 
                565                 570                 575     


Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu 
            580                 585                 590         


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
        595                 600                 605             


Met Asn Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
    610                 615                 620                 


Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
625                 630                 635                 640 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                645                 650                 655     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            660                 665                 670         


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        675                 680                 685             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    690                 695                 700                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
705                 710                 715                 720 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                725                 730                 735     


Leu Pro Pro Arg 
            740 


<210>  235
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3-CD28-2F5PSMA-CAR varICOS CD3z

<400>  235

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Phe Trp Val Leu Val Val Val Gly 
        195                 200                 205             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    210                 215                 220                 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
225                 230                 235                 240 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                245                 250                 255     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Gln Thr 
            260                 265                 270         


Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
        275                 280                 285             


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
    290                 295                 300                 


Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala 
305                 310                 315                 320 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
                325                 330                 335     


Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro 
            340                 345                 350         


Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp 
        355                 360                 365             


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
    370                 375                 380                 


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser 
385                 390                 395                 400 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser 
                405                 410                 415     


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln 
        435                 440                 445             


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    450                 455                 460                 


Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp 
465                 470                 475                 480 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala 
                485                 490                 495     


Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            500                 505                 510         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
        515                 520                 525             


Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly 
    530                 535                 540                 


Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala Pro 
545                 550                 555                 560 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                565                 570                 575     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            580                 585                 590         


Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly Cys Ala Ala 
        595                 600                 605             


Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr 
    610                 615                 620                 


Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met 
625                 630                 635                 640 


Asn Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val 
                645                 650                 655     


Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            660                 665                 670         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        675                 680                 685             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    690                 695                 700                 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
705                 710                 715                 720 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                725                 730                 735     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            740                 745                 750         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        755                 760                 765             


Pro Pro Arg 
    770     


<210>  236
<211>  1030
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1A132L-4-1BB-TIM3-CD28-2F5PSMA-CAR varICOS CD3z

<400>  236

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Lys Gln 
225                 230                 235                 240 


Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
                245                 250                 255     


Pro Gly Pro Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu 
            260                 265                 270         


Leu Leu Leu Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu 
        275                 280                 285             


Val Gly Gln Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro 
    290                 295                 300                 


Gly Asn Leu Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe 
305                 310                 315                 320 


Glu Cys Gly Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr 
                325                 330                 335     


Trp Thr Ser Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val 
            340                 345                 350         


Ser Leu Thr Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys 
        355                 360                 365             


Cys Arg Ile Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu 
    370                 375                 380                 


Lys Leu Val Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln 
385                 390                 395                 400 


Arg Asp Phe Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His 
                405                 410                 415     


Gly Pro Ala Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu 
            420                 425                 430         


Thr Gln Ile Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala 
        435                 440                 445             


Asn Asp Leu Arg Asp Ser Gly Ala Thr Ile Arg Phe Trp Val Leu Val 
    450                 455                 460                 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
465                 470                 475                 480 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
                485                 490                 495     


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
            500                 505                 510         


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val 
        515                 520                 525             


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
    530                 535                 540                 


Ser Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
545                 550                 555                 560 


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Val Gln Leu Val Gln 
                565                 570                 575     


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
            580                 585                 590         


Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg 
        595                 600                 605             


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly 
    610                 615                 620                 


Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile 
625                 630                 635                 640 


Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu 
                645                 650                 655     


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe 
            660                 665                 670         


Leu Trp Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    690                 695                 700                 


Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
705                 710                 715                 720 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
                725                 730                 735     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            740                 745                 750         


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
        755                 760                 765             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    770                 775                 780                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
785                 790                 795                 800 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr 
                805                 810                 815     


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            820                 825                 830         


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        835                 840                 845             


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu Pro Ile Gly 
    850                 855                 860                 


Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys 
865                 870                 875                 880 


Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
                885                 890                 895     


Glu Tyr Met Asn Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
            900                 905                 910         


Thr Asp Val Thr Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        915                 920                 925             


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    930                 935                 940                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
945                 950                 955                 960 


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                965                 970                 975     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            980                 985                 990         


Gly Met Lys Gly Glu Arg Arg Arg  Gly Lys Gly His Asp  Gly Leu Tyr 
        995                 1000                 1005             


Gln Gly  Leu Ser Thr Ala Thr  Lys Asp Thr Tyr Asp  Ala Leu His 
    1010                 1015                 1020             


Met Gln  Ala Leu Pro Pro Arg  
    1025                 1030 


