                         SEQUENCE LISTING

<110>  Phanes Therapeutics, Inc.
 
<120>  Anti-CD73 Antibodies and Uses Thereof

<130>  689204.10WO

<150>  US62/640,955
<151>  2018-03-09

<150>  US62/721,044
<151>  2018-08-22

<150>  US62/786,598
<151>  2018-12-31

<160>  299   

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A Heavy Chain Variable Region

<400>  1

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Thr Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Met Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Pro Ile Thr Thr Val Val Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A Light Chain Variable Region

<400>  2

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Leu Val His Ser 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Gln 
            100                 105                 110         


<210>  3
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A Heavy Chain Variable Region

<400>  3

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Phe Gly Ser Ser Tyr Arg Gly Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A Light Chain Variable Region

<400>  4

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Arg Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A Heavy Chain Variable Region

<400>  5

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Gly Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ser Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Tyr Tyr Tyr Gly Ser Ser Gly Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A Light Chain Variable Region

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A Heavy Chain Variable Region

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Asn Val Ile Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Asp Gly Tyr Leu Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A Light Chain Variable Region

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A Heavy Chain Variable Region

<400>  9

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Trp Asp Tyr Tyr Gly Ser Thr Tyr Gly Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A Light Chain Variable Region

<400>  10

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Asn Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Ile Pro Gly Lys Thr Tyr Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A Heavy Chain Variable Region

<400>  11

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Phe Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A Light Chain Variable Region

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Glu Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  13
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A Heavy Chain Variable Region

<400>  13

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Gln Tyr Val Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Thr 
    


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A Light Chain Variable Region

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 
            20                  25                  30          


Leu Thr Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Phe Cys Leu Gln Tyr Ala Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A Heavy Chain Variable Region

<400>  15

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Lys Ser Asn Tyr Gly Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A Light Chain Variable Region

<400>  16

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Glu Ala Ser Asp His Ile Asp Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A Heavy Chain Variable Region

<400>  17

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Gly Arg Val Tyr Tyr Asp Tyr Phe Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A Light Chain Variable Region

<400>  18

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A Heavy Chain Variable Region

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  20
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A Light Chain Variable Region

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A Heavy Chain Variable Region

<400>  21

Glu Leu Ala Arg Pro Trp Ala Ser Val Lys Ile Ser Cys Gln Ala Phe 
1               5                   10                  15      


Tyr Thr Phe Ser Arg Arg Met His Phe Ala Ile Arg Asp Thr Asn Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Ser Asn Tyr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A Light Chain Variable Region

<400>  22

Asp Ile Val Met Thr Gln Phe His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A Heavy Chain Variable Region

<400>  23

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ile Phe Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A Light Chain Variable Region

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  25
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A Heavy Chain Variable Region

<400>  25

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A Light Chain Variable Region

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A Heavy Chain Variable Region

<400>  27

Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Lys Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Ser Tyr Val Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A Light Chain Variable Region

<400>  28

Asp Ile Val Met Thr Gln Ala Ala Ile Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Ser Ser Asn Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Asp Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      


Leu Glu Arg Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A Heavy Chain Variable Region

<400>  29

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ile Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Glu Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Asn Trp Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  30
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A Light Chain Variable Region

<400>  30

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  31
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A Heavy Chain Variable Region

<400>  31

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Pro Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Ala Gly Ser Ser Ser Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly His Gly Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A Light Chain Variable Region

<400>  32

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A Heavy Chain Variable Region

<400>  33

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Ser Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Ala Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  34
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A Light Chain Variable Region

<400>  34

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  35
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A Heavy Chain Variable Region

<400>  35

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Ile Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Tyr Tyr Gly Asn Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A Light Chain Variable Region

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asp Thr Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Ser Met Gln Pro 
65                  70                  75                  80  


Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  37
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A Heavy Chain Variable Region

<400>  37

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Asn Tyr Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Glu Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Tyr Gly Tyr Ser Pro Ser Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  38
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A Light Chain Variable Region

<400>  38

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  39
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A Heavy Chain Variable Region

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Ser Gly Ala Thr Asn Ser Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A Light Chain Variable Region

<400>  40

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A HC CDR1

<400>  41

Gly Phe Ser Leu Ser Thr Phe Gly Met Gly 
1               5                   10  


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A HC CDR2

<400>  42

Ile Trp Trp Asp Asp Asp Met 
1               5           


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A HC CDR3

<400>  43

Ala Arg Ser Pro Ile Thr Thr Val Val Ala Asp Tyr 
1               5                   10          


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A HC CDR1

<400>  44

Gly Tyr Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A HC CDR2

<400>  45

Ile Leu Pro Gly Ser Gly Ser Thr 
1               5               


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A HC CDR3

<400>  46

Ala Arg Gly Asp Tyr Phe Gly Ser Ser Tyr Arg Gly Pro Tyr 
1               5                   10                  


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A HC CDR1

<400>  47

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A HC CDR2

<400>  48

Ile Asp Pro Ser Gly Gly Tyr Thr 
1               5               


<210>  49
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A HC CDR3

<400>  49

Ala Arg Asn Tyr Tyr Tyr Gly Ser Ser Gly Thr Met Asp Tyr 
1               5                   10                  


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A HC CDR1

<400>  50

Gly Tyr Thr Phe Ser Asn Tyr Trp 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A HC CDR2

<400>  51

Ile Leu Pro Gly Asn Val Ile Thr 
1               5               


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A HC CDR3

<400>  52

Ala Arg Arg Gly Asp Asp Gly Tyr Leu Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A HC CDR1

<400>  53

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A HC CDR2

<400>  54

Ile Tyr Pro Gly Ser Gly Asn Thr 
1               5               


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A HC CDR3

<400>  55

Ala Arg Tyr Trp Asp Tyr Tyr Gly Ser Thr Tyr Gly Tyr Phe Asp Val 
1               5                   10                  15      


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A HC CDR1

<400>  56

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A HC CDR2

<400>  57

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A HC CDR3

<400>  58

Ala Arg Asp Tyr Phe Trp Tyr Phe Asp Val 
1               5                   10  


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A HC CDR1

<400>  59

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A HC CDR2

<400>  60

Ile Trp Ser Gly Gly Ser Thr 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A HC CDR3

<400>  61

Ala Ser Gln Tyr Val Ala Tyr 
1               5           


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A HC CDR1

<400>  62

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A HC CDR2

<400>  63

Ile Asn Pro Ser Asn Gly Gly Thr 
1               5               


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A HC CDR3

<400>  64

Ala Arg Ser Lys Ser Asn Tyr Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A HC CDR1

<400>  65

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A HC CDR2

<400>  66

Ile Asn Pro Ser Asn Gly Arg Thr 
1               5               


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A HC CDR3

<400>  67

Ala Arg Ser Glu Gly Arg Val Tyr Tyr Asp Tyr Phe Tyr Ala Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A HC CDR1

<400>  68

Gly Tyr Ala Phe Thr Asn Tyr Leu 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A HC CDR2

<400>  69

Ile Asn Pro Gly Ser Gly Gly Thr 
1               5               


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A HC CDR3

<400>  70

Ala Arg Asp Tyr Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A HC CDR1

<400>  71

Ala Ile Arg Asp Thr Asn Tyr Trp 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A HC CDR2

<400>  72

Ile Tyr Pro Gly Asn Gly Asp Thr 
1               5               


<210>  73
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A HC CDR3

<400>  73

Ala Thr Tyr Tyr Ser Asn Tyr Gly Gly Ala Met Asp Tyr 
1               5                   10              


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A HC CDR1

<400>  74

Gly Tyr Thr Phe Thr Asp Tyr Ser 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A HC CDR2

<400>  75

Ile Asn Thr Glu Thr Gly Glu Pro 
1               5               


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A HC CDR3

<400>  76

Ala Arg Asp Ile Phe Trp Ala Met Asp Tyr 
1               5                   10  


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A HC CDR1

<400>  77

Gly Tyr Thr Phe Thr Ser Tyr Asn 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A HC CDR2

<400>  78

Ile Tyr Pro Gly Asn Gly Asp Thr 
1               5               


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A HC CDR3

<400>  79

Ala Arg Tyr Asp Tyr Asp Ala Met Asp Tyr 
1               5                   10  


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A HC CDR1

<400>  80

Gly Tyr Ser Phe Thr Gly Tyr Asn 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A HC CDR2

<400>  81

Ile Asn Pro Tyr Tyr Gly Ser Thr 
1               5               


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A HC CDR3

<400>  82

Ala Gly Ser Ser Tyr Val Asp Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A HC CDR1

<400>  83

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A HC CDR2

<400>  84

Ile Ile Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A HC CDR3

<400>  85

Ala Arg Trp Gly Asn Trp Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A HC CDR1

<400>  86

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A HC CDR2

<400>  87

Ile Tyr Ala Gly Ser Ser Ser Ser 
1               5               


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A HC CDR3

<400>  88

Ala Arg Ser Gly His Gly Tyr Asp Gly Phe Ala Tyr 
1               5                   10          


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A HC CDR1

<400>  89

Gly Tyr Ala Phe Ser Ser Tyr Trp 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A HC CDR2

<400>  90

Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5               


<210>  91
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A HC CDR3

<400>  91

Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr 
1               5                   10                  


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A HC CDR1

<400>  92

Gly Tyr Ala Phe Thr Asn Tyr Leu 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A HC CDR2

<400>  93

Ile Asn Pro Gly Ser Gly Gly Thr 
1               5               


<210>  94
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A HC CDR3

<400>  94

Ala Arg Arg Gly Asp Tyr Tyr Gly Asn Pro Phe Asp Tyr 
1               5                   10              


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A HC CDR1

<400>  95

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A HC CDR2

<400>  96

Ile Asp Pro Ser Asp Asn Tyr Thr 
1               5               


<210>  97
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A HC CDR3

<400>  97

Ala Arg Gly Tyr Tyr Gly Tyr Ser Pro Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A HC CDR1

<400>  98

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A HC CDR2

<400>  99

Ile Asn Pro Tyr Ser Gly Ala Thr 
1               5               


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A HC CDR3

<400>  100

Ala Arg Ser Tyr Tyr Gly Ala Met Asp Tyr 
1               5                   10  


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A LC CDR1

<400>  101

Gln Asn Leu Val His Ser Tyr Gly Asn Thr Tyr 
1               5                   10      


<210>  102
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A LC CDR2

<400>  102

Lys Val Ser 
1           


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A LC CDR3

<400>  103

Ser Gln Asn Thr His Val Pro Trp Thr 
1               5                   


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A LC CDR1

<400>  104

Gln Ser Leu Leu Asp Ser Asp Gly Arg Thr Tyr 
1               5                   10      


<210>  105
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A LC CDR2

<400>  105

Leu Val Ser 
1           


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A LC CDR3

<400>  106

Trp Gln Gly Thr His Phe Pro His Thr 
1               5                   


<210>  107
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A LC CDR1

<400>  107

Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  108
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A LC CDR2

<400>  108

Phe Ala Ser 
1           


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A LC CDR3

<400>  109

Gln Gln His Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A LC CDR1

<400>  110

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  111
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A LC CDR2

<400>  111

Ala Ala Ser 
1           


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A LC CDR3

<400>  112

Gln Gln Ser Lys Glu Val Pro Phe Thr 
1               5                   


<210>  113
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A LC CDR1

<400>  113

Lys Asn Ile Ser Lys Tyr 
1               5       


<210>  114
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A LC CDR2

<400>  114

Ser Gly Ser 
1           


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A LC CDR3

<400>  115

Gln Gln His Asn Glu Tyr Pro Phe Thr 
1               5                   


<210>  116
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A LC CDR1

<400>  116

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  117
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A LC CDR2

<400>  117

Trp Ala Ser 
1           


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A LC CDR3

<400>  118

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  119
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A LC CDR1

<400>  119

Gln Asp Ile Gly Ser Arg 
1               5       


<210>  120
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A LC CDR2

<400>  120

Ala Thr Ser 
1           


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A LC CDR3

<400>  121

Leu Gln Tyr Ala Ser Ser Pro Phe Thr 
1               5                   


<210>  122
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A LC CDR1

<400>  122

Asp His Ile Asp Asn Trp 
1               5       


<210>  123
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A LC CDR2

<400>  123

Gly Ala Thr 
1           


<210>  124
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A LC CDR3

<400>  124

Gln Gln Tyr Trp Ser Ser Pro Phe Thr 
1               5                   


<210>  125
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A LC CDR1

<400>  125

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  126
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A LC CDR2

<400>  126

Tyr Thr Ser 
1           


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A LC CDR3

<400>  127

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  128
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A LC CDR1

<400>  128

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  129
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A LC CDR2

<400>  129

Trp Ala Ser 
1           


<210>  130
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A LC CDR3

<400>  130

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A LC CDR1

<400>  131

Gln Asp Val Gly Thr Ala Val Ala 
1               5               


<210>  132
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A LC CDR2

<400>  132

Trp Ala Ser 
1           


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A LC CDR3

<400>  133

Gln Gln Tyr Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  134
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A LC CDR1

<400>  134

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  135
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A LC CDR2

<400>  135

Trp Ala Ser 
1           


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A LC CDR3

<400>  136

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  137
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A LC CDR1

<400>  137

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  138
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A LC CDR2

<400>  138

Asn Ala Lys 
1           


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A LC CDR3

<400>  139

Gln His His Tyr Gly Thr Pro Phe Thr 
1               5                   


<210>  140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A LC CDR1

<400>  140

Lys Ser Leu Leu His Ser Asn Asp Ile Thr Tyr 
1               5                   10      


<210>  141
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A LC CDR2

<400>  141

Arg Met Ser 
1           


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A LC CDR3

<400>  142

Ala Gln Met Leu Glu Arg Pro Trp Thr 
1               5                   


<210>  143
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A LC CDR1

<400>  143

Ser Ser Val Ser Tyr 
1               5   


<210>  144
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A LC CDR2

<400>  144

Leu Thr Ser 
1           


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A LC CDR3

<400>  145

Gln Gln Trp Ser Ser Asn Pro Trp Thr 
1               5                   


<210>  146
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A LC CDR1

<400>  146

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  147
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A LC CDR2

<400>  147

Tyr Thr Ser 
1           


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A LC CDR3

<400>  148

Gln Gln Tyr Ser Lys Leu Pro Arg Thr 
1               5                   


<210>  149
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A LC CDR1

<400>  149

Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  150
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A LC CDR2

<400>  150

Phe Ala Ser 
1           


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A LC CDR3

<400>  151

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  152
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A LC CDR1

<400>  152

Glu Asn Ile Tyr Tyr Ser 
1               5       


<210>  153
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A LC CDR2

<400>  153

Asn Ala Asp 
1           


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A LC CDR3

<400>  154

Lys Gln Ala Tyr Asp Val Pro Leu Thr 
1               5                   


<210>  155
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A LC CDR1

<400>  155

Ser Ser Val Ser Tyr 
1               5   


<210>  156
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A LC CDR2

<400>  156

Leu Thr Ser 
1           


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A LC CDR3

<400>  157

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  158
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A LC CDR1

<400>  158

Gln Asp Ile Asn Ser Tyr 
1               5       


<210>  159
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A LC CDR2

<400>  159

Arg Ala Asn 
1           


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A LC CDR3

<400>  160

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  161
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A HC CDR1

<400>  161

Gly Phe Ser Leu Ser Thr Phe Gly Met Gly Val Thr 
1               5                   10          


<210>  162
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A HC CDR2

<400>  162

His Ile Trp Trp Asp Asp Asp Met Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A HC CDR3

<400>  163

Ala Arg Ser Pro Ile Thr Thr Val Val Ala Asp Tyr 
1               5                   10          


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A HC CDR1

<400>  164

Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu 
1               5                   10  


<210>  165
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A HC CDR2

<400>  165

Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  166
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A HC CDR3

<400>  166

Ala Arg Gly Asp Tyr Phe Gly Ser Ser Tyr Arg Gly Pro Tyr 
1               5                   10                  


<210>  167
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A HC CDR1

<400>  167

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  168
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A HC CDR2

<400>  168

Glu Ile Asp Pro Ser Gly Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  169
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A HC CDR3

<400>  169

Ala Arg Asn Tyr Tyr Tyr Gly Ser Ser Gly Thr Met Asp Tyr 
1               5                   10                  


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A HC CDR1

<400>  170

Gly Tyr Thr Phe Ser Asn Tyr Trp Ile Glu 
1               5                   10  


<210>  171
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A HC CDR2

<400>  171

Glu Ile Leu Pro Gly Asn Val Ile Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  172
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A HC CDR3

<400>  172

Ala Arg Arg Gly Asp Asp Gly Tyr Leu Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  173
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A HC CDR1

<400>  173

Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
1               5                   10  


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A HC CDR2

<400>  174

Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  175
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A HC CDR3

<400>  175

Ala Arg Tyr Trp Asp Tyr Tyr Gly Ser Thr Tyr Gly Tyr Phe Asp Val 
1               5                   10                  15      


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A HC CDR1

<400>  176

Gly Tyr Thr Phe Thr Asp Tyr Asn Met His 
1               5                   10  


<210>  177
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A HC CDR2

<400>  177

Tyr Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A HC CDR3

<400>  178

Ala Arg Asp Tyr Phe Trp Tyr Phe Asp Val 
1               5                   10  


<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A HC CDR1

<400>  179

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  180
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A HC CDR2

<400>  180

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


Arg 
    


<210>  181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A HC CDR3

<400>  181

Ala Ser Gln Tyr Val Ala Tyr 
1               5           


<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A HC CDR1

<400>  182

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  183
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A HC CDR2

<400>  183

Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  184
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A HC CDR3

<400>  184

Ala Arg Ser Lys Ser Asn Tyr Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  185
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A HC CDR1

<400>  185

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  186
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A HC CDR2

<400>  186

Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  187
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A HC CDR3

<400>  187

Ala Arg Ser Glu Gly Arg Val Tyr Tyr Asp Tyr Phe Tyr Ala Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  188
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A HC CDR1

<400>  188

Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  189
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A HC CDR2

<400>  189

Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A HC CDR3

<400>  190

Ala Arg Asp Tyr Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  191
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A HC CDR1

<400>  191

Ala Ile Arg Asp Thr Asn Tyr Trp Met Gln 
1               5                   10  


<210>  192
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A HC CDR2

<400>  192

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Val 
    


<210>  193
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A HC CDR3

<400>  193

Ala Thr Tyr Tyr Ser Asn Tyr Gly Gly Ala Met Asp Tyr 
1               5                   10              


<210>  194
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A HC CDR1

<400>  194

Gly Tyr Thr Phe Thr Asp Tyr Ser Met His 
1               5                   10  


<210>  195
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A HC CDR2

<400>  195

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A HC CDR3

<400>  196

Ala Arg Asp Ile Phe Trp Ala Met Asp Tyr 
1               5                   10  


<210>  197
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A HC CDR1

<400>  197

Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210>  198
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A HC CDR2

<400>  198

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A HC CDR3

<400>  199

Ala Arg Tyr Asp Tyr Asp Ala Met Asp Tyr 
1               5                   10  


<210>  200
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A HC CDR1

<400>  200

Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn 
1               5                   10  


<210>  201
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A HC CDR2

<400>  201

Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  202
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A HC CDR3

<400>  202

Ala Gly Ser Ser Tyr Val Asp Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  203
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A HC CDR1

<400>  203

Gly Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  204
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A HC CDR2

<400>  204

Tyr Ile Ile Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  205
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A HC CDR3

<400>  205

Ala Arg Trp Gly Asn Trp Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A HC CDR1

<400>  206

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn 
1               5                   10  


<210>  207
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A HC CDR2

<400>  207

Asn Ile Tyr Ala Gly Ser Ser Ser Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  208
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A HC CDR3

<400>  208

Ala Arg Ser Gly His Gly Tyr Asp Gly Phe Ala Tyr 
1               5                   10          


<210>  209
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A HC CDR1

<400>  209

Gly Tyr Ala Phe Ser Ser Tyr Trp Met Asn 
1               5                   10  


<210>  210
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A HC CDR2

<400>  210

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Ser Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  211
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A HC CDR3

<400>  211

Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr 
1               5                   10                  


<210>  212
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A HC CDR1

<400>  212

Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  213
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A HC CDR2

<400>  213

Leu Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Ile Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  214
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A HC CDR3

<400>  214

Ala Arg Arg Gly Asp Tyr Tyr Gly Asn Pro Phe Asp Tyr 
1               5                   10              


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A HC CDR1

<400>  215

Gly Tyr Thr Phe Thr Asn Tyr Trp Met Gln 
1               5                   10  


<210>  216
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A HC CDR2

<400>  216

Glu Ile Asp Pro Ser Asp Asn Tyr Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  217
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A HC CDR3

<400>  217

Ala Arg Gly Tyr Tyr Gly Tyr Ser Pro Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  218
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A HC CDR1

<400>  218

Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  219
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A HC CDR2

<400>  219

Arg Ile Asn Pro Tyr Ser Gly Ala Thr Asn Ser Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  220
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A HC CDR3

<400>  220

Ala Arg Ser Tyr Tyr Gly Ala Met Asp Tyr 
1               5                   10  


<210>  221
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A LC CDR1

<400>  221

Arg Ser Ser Gln Asn Leu Val His Ser Tyr Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  222
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A LC CDR2

<400>  222

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  223
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37C7A LC CDR3

<400>  223

Ser Gln Asn Thr His Val Pro Trp Thr 
1               5                   


<210>  224
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A LC CDR1

<400>  224

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Arg Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A LC CDR2

<400>  225

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  226
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38C16A LC CDR3

<400>  226

Trp Gln Gly Thr His Phe Pro His Thr 
1               5                   


<210>  227
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A LC CDR1

<400>  227

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  228
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A LC CDR2

<400>  228

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  229
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8A LC CDR3

<400>  229

Gln Gln His Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  230
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A LC CDR1

<400>  230

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  231
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A LC CDR2

<400>  231

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  232
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43E8A LC CDR3

<400>  232

Gln Gln Ser Lys Glu Val Pro Phe Thr 
1               5                   


<210>  233
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A LC CDR1

<400>  233

Arg Ala Ser Lys Asn Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  234
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A LC CDR2

<400>  234

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  235
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46J3A LC CDR3

<400>  235

Gln Gln His Asn Glu Tyr Pro Phe Thr 
1               5                   


<210>  236
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A LC CDR1

<400>  236

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A LC CDR2

<400>  237

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  238
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46O19A LC CDR3

<400>  238

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  239
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A LC CDR1

<400>  239

Arg Ala Ser Gln Asp Ile Gly Ser Arg Leu Thr 
1               5                   10      


<210>  240
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A LC CDR2

<400>  240

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  241
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47H24A LC CDR3

<400>  241

Leu Gln Tyr Ala Ser Ser Pro Phe Thr 
1               5                   


<210>  242
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A LC CDR1

<400>  242

Glu Ala Ser Asp His Ile Asp Asn Trp Leu Ala 
1               5                   10      


<210>  243
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A LC CDR2

<400>  243

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49O5A LC CDR3

<400>  244

Gln Gln Tyr Trp Ser Ser Pro Phe Thr 
1               5                   


<210>  245
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A LC CDR1

<400>  245

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  246
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A LC CDR2

<400>  246

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  247
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50B10A LC CDR3

<400>  247

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  248
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A LC CDR1

<400>  248

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A LC CDR2

<400>  249

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  250
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50H17A LC CDR3

<400>  250

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  251
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A LC CDR1

<400>  251

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  252
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A LC CDR2

<400>  252

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  253
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50E16A LC CDR3

<400>  253

Gln Gln Tyr Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  254
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A LC CDR1

<400>  254

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  255
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A LC CDR2

<400>  255

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  256
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50F1A LC CDR3

<400>  256

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A LC CDR1

<400>  257

Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Phe Ala 
1               5                   10      


<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A LC CDR2

<400>  258

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  259
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54I14A LC CDR3

<400>  259

Gln His His Tyr Gly Thr Pro Phe Thr 
1               5                   


<210>  260
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A LC CDR1

<400>  260

Ser Ser Asn Lys Ser Leu Leu His Ser Asn Asp Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  261
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A LC CDR2

<400>  261

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  262
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52K11A LC CDR3

<400>  262

Ala Gln Met Leu Glu Arg Pro Trp Thr 
1               5                   


<210>  263
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A LC CDR1

<400>  263

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  264
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A LC CDR2

<400>  264

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  265
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53H21A LC CDR3

<400>  265

Gln Gln Trp Ser Ser Asn Pro Trp Thr 
1               5                   


<210>  266
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A LC CDR1

<400>  266

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  267
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A LC CDR2

<400>  267

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  268
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53I12A LC CDR3

<400>  268

Gln Gln Tyr Ser Lys Leu Pro Arg Thr 
1               5                   


<210>  269
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A LC CDR1

<400>  269

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  270
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A LC CDR2

<400>  270

Phe Ala Ser Thr Arg Asp Ser 
1               5           


<210>  271
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9A LC CDR3

<400>  271

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  272
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A LC CDR1

<400>  272

Arg Ala Ser Glu Asn Ile Tyr Tyr Ser Leu Ala 
1               5                   10      


<210>  273
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A LC CDR2

<400>  273

Asn Ala Asp Thr Leu Glu Asp 
1               5           


<210>  274
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39J9A LC CDR3

<400>  274

Lys Gln Ala Tyr Asp Val Pro Leu Thr 
1               5                   


<210>  275
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A LC CDR1

<400>  275

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  276
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A LC CDR2

<400>  276

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  277
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49H8A LC CDR3

<400>  277

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  278
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A LC CDR1

<400>  278

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  279
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A LC CDR2

<400>  279

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  280
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51B10A LC CDR3

<400>  280

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  281
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
                405                 410                 415     


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
            420                 425                 430         


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
        435                 440                 445             


Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 
    450                 455                 460                 


Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 
465                 470                 475                 480 


Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 
                485                 490                 495     


Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 
            500                 505                 510         


Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 
        515                 520                 525             


Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 
    530                 535                 540                 


Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 
545                 550                 555                 560 


Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
                565                 570                 


<210>  282
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-H1 Heavy Chain Variable Region

<400>  282

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Asn Pro Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  283
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-H2 Heavy Chain Variable Region

<400>  283

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Asn Pro Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  284
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-H3 Heavy Chain Variable Region

<400>  284

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Asn Pro Ser Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Ala Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  285
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-H4 Heavy Chain Variable Region

<400>  285

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Ser Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Ala Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  286
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-H5 Heavy Chain Variable Region

<400>  286

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gln 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Ser Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Ala Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  287
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8-H1 Heavy Chain Variable Region

<400>  287

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Gly Gly Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ser Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Tyr Tyr Tyr Gly Ser Ser Gly Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  288
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8-H2 Heavy Chain Variable Region

<400>  288

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Gly Gly Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ser Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Tyr Tyr Tyr Gly Ser Ser Gly Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  289
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8-H3 Heavy Chain Variable Region

<400>  289

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Gly Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ser Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Tyr Tyr Tyr Gly Ser Ser Gly Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  290
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-L1 Light Chain Variable Region

<400>  290

Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  291
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-L2 Light Chain Variable Region

<400>  291

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  292
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-L3 Light Chain Variable Region

<400>  292

Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  293
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-L4 Light Chain Variable Region

<400>  293

Asp Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  294
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39G8-L3 Light Chain Variable Region

<400>  294

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  295
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-H6 Heavy Chain Variable Region

<400>  295

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Ala Pro Arg Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  296
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-H7 Heavy Chain Variable Region

<400>  296

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  297
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-H8 Heavy Chain Variable Region

<400>  297

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Ser Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  298
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-H9 Heavy Chain Variable Region

<400>  298

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Tyr Tyr Ser Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Ala Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Tyr Tyr Gly Asn Tyr Val Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  299
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60A9-L5  Light Chain Variable Region

<400>  299

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Gln Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Ala Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Val 
            100                 105                 110         


Lys 
    


