                         SEQUENCE LISTING

<110>  TargImmune Therapeutics AG
 
<120>  A RECOMBINANT PROTEIN COMPRISING A DOUBLE STRANDED RNA BINDING 
       DOMAIN

<130>  P5486PC00

<150>  EP18160819.1
<151>  2018-03-08

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab antibody heavy chain

<400>  1

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  2
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab antibody light chain

<400>  2

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer 1

<400>  3

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer 2

<400>  4

Gly Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  5
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr Tyr Arg Gln Lys Gln 
1               5                   10                  15      


Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn Ser Gly Pro Pro His 
            20                  25                  30          


Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp Gly Arg Glu Phe Pro 
        35                  40                  45              


Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys Asn Ala Ala Ala Lys 
    50                  55                  60                  


Leu Ala Val Glu Ile Leu Asn Lys Glu Lys 
65                  70                  


<210>  6
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  6

Leu Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys 
1               5                   10                  15      


Lys Arg Leu Thr Val Asn Tyr Glu Gln Val Ala Ser Gly Val His Gly 
            20                  25                  30          


Pro Glu Gly Phe His Tyr Lys Val Lys Met Gly Gln Lys Glu Tyr Ser 
        35                  40                  45              


Ile Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys 
    50                  55                  60                  


Leu Ala Tyr Leu Gln Ile Leu Ser Glu 
65                  70              


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Lys Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu 
1               5                   10                  15      


Gly Leu Ser Met Gly 
            20      


<210>  8
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Val Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Val Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu 
                165             


<210>  9
<211>  507
<212>  DNA
<213>  Homo sapiens

<400>  9
atgatggctg gtgatctttc cgctggcttc ttcatggaag agttgaacac ctacaggcaa       60

aagcagggcg ttgtgctcaa gtaccaagag cttccaaatt ccggaccacc acacgatagg      120

cgtttcactt tccaggtgat catcgatgga cgtgagttcc cagaaggtga gggcagatct      180

aagaaagagg ctaagaacgc tgctgctaag ctcgctgttg agatcctgaa caaagagaag      240

aaggccgtca gtccactcct cctgactact actaattcct ccgagggact ctccatggga      300

aactacattg gactcatcaa caggatcgcc cagaagaaga ggctcaccgt taactacgag      360

caagtggctt ctggtgttca tggaccagag ggattccact acaaggtgaa gatgggccag      420

aaagagtact ccatcggaac tggctctacc aagcaagagg caaagcaact ggctgccaaa      480

cttgcttacc tccagattct ttccgag                                          507


<210>  10
<211>  1346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cetuximab antibody heavy chain, nucleic acid sequence

<400>  10
caggtgcagc ttaagcagtc tggaccagga cttgttcagc cttctcagtc cctctccatt       60

acttgcactg tgtccggatt ctccctcacc aattacggtg ttcactgggt gagacagtct      120

ccaggtaagg gtcttgaatg gctcggagtg atttggtccg gtggcaacac tgattacaac      180

accccattca cctccaggct ctccatcaac aaggacaact ccaagagcca ggtgttcttc      240

aagatgaact ccctccagtc caacgacacc gctatctatt attgcgctag ggctctcacc      300

tactacgact acgagtttgc ttactgggga cagggaactc tcgttactgt ttccgctgct      360

tctaccaagg gaccatctgt ttttccactc gctcccagct ctaagtccac ttctggtgga      420

actgctgctc ttggatgcct cgtgaaggat tactttccag agccagtgac cgtgtcctgg      480

aactctggtg ctcttacttc aggcgttcac actttcccag ctgtgcttca atcttccgga      540

ctctactctc tctcctctgt tgtgactgtg ccctcttctt cactcggcac tcaaacctac      600

atctgcaacg tgaaccacaa gccatccaac accaaggtgg acaagaaggt cgagccaaag      660

tcctgcgata agactcatac ttgcccacca tgtccagctc cagaacttct tggtggtcca      720

tccgttttct tgttcccacc aaagccaaag gacaccctca tgatctctag gactccagag      780

gttacatgcg tggtggttga tgtgtctcat gaagatcctg aggtgaagtt caactggtac      840

gttgacggtg ttgaggtgca caacgctaag actaagccac gtgaggaaca gtacaactcc      900

acctacaggg ttgtgtctgt gcttactgtg ttgcaccagg attggctcaa cggcaaagag      960

tacaagtgca aggtgtccaa caaggctctc cctgctccaa tcgaaaagac catctctaag     1020

gctaagggcc agccaagaga gccacaggtt tacactcttc caccatccag ggacgagctg     1080

accaagaatc aggtttccct tacttgcctg gtgaagggct tctacccatc cgatattgct     1140

gttgagtggg agtctaatgg ccagcctgag aacaactaca agactactcc accagtgctc     1200

gactccgatg gctcattctt cttgtactcc aagctcaccg tggacaagtc tagatggcag     1260

cagggaaacg tgttcagctg ctctgttatg catgaggccc ttcacaacca ctacacccag     1320

aagtccttgt ctttgtctcc aggcaa                                          1346


<210>  11
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cetuximab antibody light chain nucleic acid sequence

<400>  11
gacatcctgc tcactcagtc tccagtgatc ctttctgttt ccccaggtga gagggtgtca       60

ttttcttgca gggcttccca gtccatcggc actaacattc attggtatca gcagaggacc      120

aacggctctc caaggctcct tattaagtac gcctccgagt ccatctccgg cattccatct      180

agattctccg gatctggctc cggcactgat ttcacccttt ccatcaactc cgttgagtcc      240

gaggatatcg ctgactacta ctgccagcag aacaacaact ggccaactac tttcggagct      300

ggcaccaagt tggagcttaa gagaactgtt gctgccccat ccgtgttcat cttcccacca      360

tctgatgagc agctcaagtc cggaactgct tctgttgtgt gcctcctcaa caacttctac      420

ccaagggaag ctaaggtgca gtggaaggtt gacaatgctc tccagtccgg aaactcccaa      480

gagtcagtta cagagcagga ctccaaggac tctacctaca gcctcagctc tactctcact      540

ctcagcaagg ctgattacga gaagcacaag gtgtacgctt gcgaggttac acaccaggga      600

ctttcttcac cagtgaccaa gtctttcaac aggggagagt gt                         642


<210>  12
<211>  1016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plant promoter from a rubisco small subunit

<400>  12
aattcgatat cacgcttaga caaacacccc ttgttataca aagaatttcg ctttacaaaa       60

tcaaattcga gaaaataata tatgcactaa ataagatcat tccgatccaa tctaaccaat      120

tacgatacgc tttgggtaca cttgattttt gtttcagtag ttacatatat cttgttttat      180

atgctatctt taaggatctt cactcaaaga ctatttgttg atgttcttga tggggctcgg      240

aagatttgat atgatacact ctaatcttta ggagatacca gccaggatta tattcagtaa      300

gacaatcaaa ttttacgtgt tcaaactcgt tatcttttca tttaatggat gagccagaat      360

ctctatagaa tgattgcaat cgagaatatg ttcggccgat atccctttgt tggcttcaat      420

attctacata tcacacaaga atcgaccgta ttgtaccctc tttccataaa ggaacacaca      480

gtatgcagat gcttttttcc cacatgcagt aacataggta ttcaaaaatg gctaaaagaa      540

gttggataac aaattgacaa ctatttccat ttctgttata taaatttcac aacacacaaa      600

agcccgtaat caagagtctg cccatgtacg aaataacttc tattatttgg tattgggcct      660

aagcccagct cagagtacgt gggggtacca catataggaa ggtaacaaaa tactgcaaga      720

tagccccata acgtaccagc ctctccttac cacgaagaga taagatataa gacccaccct      780

gccacgtgtc acatcgtcat ggtggttaat gataagggat tacatccttc tatgtttgtg      840

gacatgatgc atgtaatgtc atgagccaca tgatccaatg gccacaggaa cgtaagaatg      900

tagatagatt tgattttgtc cgttagatag caaacaacat tataaaaggt gtgtatcaat      960

acgaactaat tcactcattg gattcataga agtccattcc tcctaagtat ctaaac         1016


<210>  13
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plant terminator from a rubisco small subunit

<400>  13
ggccgcataa gttttactat ttaccaagac ttttgaatat taaccttctt gtaacgagtc       60

ggttaaattt gattgtttag ggttttgtat tatttttttt tggtctttta attcatcact      120

ttaattccct aattgtctgt tcatttcgtt gtttgtttcc ggatcgataa tgaaatgtaa      180

gagatatcat atataaataa taaattgtcg tttcatattt gcaatctttt tttacaaacc      240

tttaattaat tgtatgtatg acattttctt cttgttatat tagggggaaa taatgttaaa      300

taaaagtaca aaataaacta cagtacatcg tactgaataa attacctagc caaaaagtac      360

acctttccat atacttccta catgaaggca ttttcaacat tttcaaataa ggaatgctac      420

aaccgcataa taacatccac aaattttttt ataaaataac atgtcagaca gtgattgaaa      480

gattttatta tagtttcgtt atcttctttt ctcattaagc gaatcactac ctaacacgtc      540

attttgtgaa atattttttg aatgttttta tatagttgta gcattcctct tttcaaatta      600

gggtttgttt gagatagcat ttcagccggt tcatacaact taaaagcata ctctaatgct      660

ggaaaaaaga ctaaaaaatc ttgtaagtta gcgcagaata ttgacccaaa ttatatacac      720

acatgacccc atatagagac taattacact tttaaccact aataattatt actgtattat      780

aacatctact aattaaactt gtgagttttt gctagaatta ttatcatata tactaaaagg      840

caggaacgca aacattgccc cggtactgta gcaactacgg tagacgcatt aattgtctat      900

agtggacgca ttaattaacc aaaaccgcct ctttcccctt cttcttgaag ctggagctcg      960


<210>  14
<211>  117
<212>  DNA
<213>  Gossypium sp.

<400>  14
atggctagga agtcccttat tttcccagtg atccttctcg ccgtgctcct tttttctcca       60

ccaatctact ctgctggcca cgattacagg gatgctctcc gtaaatcttc catggct         117


<210>  15
<211>  75
<212>  DNA
<213>  Nicotiana sp.

<400>  15
atggccgcta ggaagtccct tattttccca gtgattctcc tcgccgtgct ccttttttct       60

ccaccaatct actcc                                                        75


<210>  16
<211>  39
<212>  PRT
<213>  Gossypium sp.

<400>  16

Met Ala Arg Lys Ser Leu Ile Phe Pro Val Ile Leu Leu Ala Val Leu 
1               5                   10                  15      


Leu Phe Ser Pro Pro Ile Tyr Ser Ala Gly His Asp Tyr Arg Asp Ala 
            20                  25                  30          


Leu Arg Lys Ser Ser Met Ala 
        35                  


<210>  17
<211>  25
<212>  PRT
<213>  Gossypium sp.

<400>  17

Met Ala Ala Arg Lys Ser Leu Ile Phe Pro Val Ile Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Phe Ser Pro Pro Ile Tyr Ser 
            20                  25  


<210>  18
<211>  845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   CHN 50 S/M II

<400>  18
aggtacagaa cgtgggaatc taagtttctg actctacatt tctacatatt tttaacttct       60

aactctgaaa gctcttatta tactaaattg tgtaattcct tagtaatatg taaatttact      120

tgaacttctt ccagaaccac tcccccaacc taattataac tttctagcta aactcagcga      180

tttttttggt tcatcgtaag acattgtcag tcgaaatatt gtactatatc catgtgaggc      240

tgattctttt taggaggagg acctaactca ctcaagagac gccgggtgta accaggctct      300

gttttttcgc caaaacaaaa aaactgggaa tcaaactttc gtgctgcacg tagatattcg      360

ccatctttaa gattaaattg aaaaccttct ccttttttat gaaattcgta cttaaatttt      420

aaaaactcgc ttgggcgtca ttctgggtga aattctttct tcctctgact aaattacaat      480

ttttttctaa gtagaatgcg tgttcaaaca tcaattcgaa ctcaaaaaat tacttttcta      540

catagtttaa gaatttcttc agttcaagta actagatcta catccaaaca ctcaccaagt      600

gggcgcttgg ctataagaat tgcaagatcc ccaaaaagta atagaaactc ttttcgtcgg      660

gtaatgatat ttagaaacta gaattatgcc tcgacatgaa catgatttta ggctgttttt      720

aatcgtttgt ctctaaccta aacgaaaact ttgaaaagta gctctttgga gtttttcaaa      780

attttaagaa attcccaaaa tacattttca agtagaagtt aaaaatactc taaaccaatg      840

tcgat                                                                  845


<210>  19
<211>  1193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TM6

<400>  19
taatatttag aaatttaatt aacataacca aggattttta tatcggtaat aactctaata       60

tggtatccaa atcagtctag aactctctta cctctaataa gtaaaagtac ttctaataaa      120

ttcatatact ttttctctct tctccgatct ctctttgctc ttctttttat gtatcctttc      180

ctttctaata gccttttatg agaagtaaac ttttagggtt ggccccccct ccccccacaa      240

ttatatagtt tcttactcag ttgttggaat ataattcaaa ttcttaaata attgacggtg      300

acattgagtt ttactttgtg gaagagaatt agattctcgt gttagtaaaa tcggttagta      360

attgatgatg cattattttt actctataat agagatgcaa ttttattttt gcattttggg      420

atcaaattgt aatgcagtca tatattgatt tcataaatgt ttgggatatt gttggttatt      480

taactagaaa tagacttctt atttcatatt tattgttaaa atcctttatt ggagatgaat      540

tatttgttca ccgattagaa gttgatagtc gcttttgttt tagaagaaat tttaccgtag      600

accaagttaa ggagttttag aagcactttg catgggagca ttagtgtatg ttatggcttt      660

atcaaatata ggttttgaag attcagagag ccaagaaaag ctagaaccca agaactagga      720

agttagagta attcacaata ccataacgtg atataaaact ttttattgta actcaaatcg      780

gtaatatttt ttgctttagt cttaatcgat aaattatttt tttatattga ttagttatag      840

gaggctcaca aagttgggaa taattaaaat atcatatttt gtatttgaac aatttatgaa      900

atagtaattg gtaaaaaatc actttaaatt tttatcctat atccagaagg attatggtgt      960

ctggcatagt tgtttggaag atttgaatca gggtaaaagt atgttgtaat ttttattttg     1020

ttataggcat tttttgtgct tgattgtttt gttgtcatta tattttatta tttggaagtg     1080

tatatatatg tttgattaaa atatagataa tcaattttat aagaaatttg caacaattac     1140

acaaggataa agtctacaat atgcgagtaa aatttgattg aacctaggat gtc            1193


<210>  20
<211>  1168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rb7

<400>  20
tcgattaaaa atcccaatta tatttggtct aatttagttt ggtattgagt aaaacaaatt       60

cgaaccaaac caaaatataa atatatagtt tttatatata tgcctttaag actttttata      120

gaattttctt taaaaaatat ctagaaatat ttgcgactct tctggcatgt aatatttcgt      180

taaatatgaa gtgctccatt tttattaact ttaaataatt ggttgtacga tcactttctt      240

atcaagtgtt actaaaatgc gtcaatctct ttgttcttcc atattcatat gtcaaaatct      300

atcaaaattc ttatatatct ttttcgaatt tgaagtgaaa tttcgataat ttaaaattaa      360

atagaacata tcattattta ggtatcatat tgatttttat acttaattac taaatttggt      420

taactttgaa agtgtacatc aacgaaaaat tagtcaaacg actaaaataa ataaatatca      480

tgtgttatta agaaaattct cctataagaa tattttaata gatcatatgt ttgtaaaaaa      540

aattaatttt tactaacaca tatatttact tatcaaaaat ttgacaaagt aagattaaaa      600

taatattcat ctaacaaaaa aaaaaccaga aaatgctgaa aacccggcaa aaccgaacca      660

atccaaaccg atatagttgg tttggtttga ttttgatata aaccgaacca actcggtcca      720

tttgcacccc taatcataat agctttaata tttcaagata ttattaagtt aacgttgtca      780

atatcctgga aattttgcaa aatgaatcaa gcctatatgg ctgtaatatg aatttaaaag      840

cagctcgatg tggtggtaat atgtaattta cttgattcta aaaaaatatc ccaagtatta      900

ataatttctg ctaggaagaa ggttagctac gatttacagc aaagccagaa tacaaagaac      960

cataaagtga ttgaagctcg aaatatacga aggaacaaat atttttaaaa aaatacgcaa     1020

tgacttggaa caaaagaaag tgatatattt tttgttctta aacaagcatc ccctctaaag     1080

aatggcagtt ttcctttgca tgtaactatt atgctccctt cgttacaaaa attttggact     1140

actattggga acttcttctg aaaatagt                                        1168


<210>  21
<211>  2393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Marker cassette

<400>  21
tgagactttt caacaaaggg taatatcggg aaacctcctc ggattccatt gcccagctat       60

ctgtcacttc atcaaaagga cagtagaaaa ggaaggtggc acctacaaat gccatcattg      120

cgataaagga aaggctatcg ttcaagatgc ctctgccgac agtggtccca aagatggacc      180

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt      240

ggattgatgt gatatctcca ctgacgtaag ggatgacgca caatcccact atccttcgca      300

agacccttcc tctatataag gaagttcatt tcatttggag aggactccgg tatttttaca      360

acaattacca caacaaaaca aacaacaaac aacattacaa tttactattc tagtcgaaat      420

ggcctcctcc gagaacgtga tcactgagtt catgaggttc aaggtgagga tggaaggtac      480

tgtgaacgga cacgagttcg agatcgaagg tgaaggtgag ggtagaccat acgagggaca      540

caacactgtg aagctcaagg tgacaaaagg tggcccactt ccattcgctt gggatatcct      600

ttcaccacag ttccagtacg gctccaaggt ttacgttaag cacccagctg atatccccga      660

ctacaagaag ttgtctttcc cagagggatt caagtgggag cgtgtgatga atttcgagga      720

tggtggtgtg gctactgtga cccaggattc ttcacttcag gatggctgct tcatctacaa      780

ggtgaagttc atcggggtga acttcccatc tgatggccca gtgatgcaga aaaagactat      840

gggatgggaa gcctccactg agaggcttta tccaagagat ggtgtgctca agggcgagac      900

tcacaaggct cttaagctca aagatggtgg ccactacctc gtcgagttca agtctatcta      960

catggccaag aagccagttc agctccccgg ttactactac gttgacgcta agctcgacat     1020

caccagccac aacgaggatt acactatcgt cgagcagtac gagaggactg aaggtaggca     1080

tcacttgttc ctctgagctt ggaatggatc ttcgatcccg atcgttcaaa catttggcaa     1140

taaagtttct taagattgaa tcctgttgcc ggtcttgcga cgattatcat ataatttctg     1200

ttgaattacg ttaagcatgt aataattaac atgtaatgca tgacgttatt tatgagatgg     1260

gtttttatga ttagagtccc gcaattatac atttaatacg cgatagaaaa caaaatatag     1320

cgcgcaaact aggataaatt atcgcgcgcg gtgtcatcta tgttactaga tcgggaattg     1380

ccaagctaat tcttgaagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt     1440

catgataata atggtttctt agacgtgagg tggcactttt cggggaaatg tgcgcggaac     1500

ccctatttgt ttatttttct aaatacagaa ttgtcgactt gtgtcgacag gtacagaacg     1560

tgggaatcta agtttctgac tctacatttc tacatatttt taacttctaa ctctgaaagc     1620

tcttattata ctaaattgtg taattcctta gtaatatgta aatttacttg aacttcttcc     1680

agaaccactc ccccaaccta attataactt tctagctaaa ctcagcgatt tttttggttc     1740

atcgtaagac attgtcagtc gaaatattgt actatatcca tgtgaggctg attcttttta     1800

ggaggaggac ctaactcact caagagacgc cgggtgtaac caggctctgt tttttcgcca     1860

aaacaaaaaa actgggaatc aaactttcgt gctgcacgta gatattcgcc atctttaaga     1920

ttaaattgaa aaccttctcc ttttttatga aattcgtact taaattttaa aaactcgctt     1980

gggcgtcatt ctgggtgaaa ttctttcttc ctctgactaa attacaattt ttttctaagt     2040

agaatgcgtg ttcaaacatc aattcgaact caaaaaatta cttttctaca tagtttaaga     2100

atttcttcag ttcaagtaac tagatctaca tccaaacact caccaagtgg gcgcttggct     2160

ataagaattg caagatcccc aaaaagtaat agaaactctt ttcgtcgggt aatgatattt     2220

agaaactaga attatgcctc gacatgaaca tgattttagg ctgtttttaa tcgtttgtct     2280

ctaacctaaa cgaaaacttt gaaaagtagc tctttggagt ttttcaaaat tttaagaaat     2340

tcccaaaata cattttcaag tagaagttaa aaatactcta aaccaatgtc gat            2393


<210>  22
<211>  504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial dsRBD

<400>  22
atggctggtg atctttccgc tggcttcttc atggaagagt tgaacaccta caggcaaaag       60

cagggcgttg tgctcaagta ccaagagctt ccaaattccg gaccaccaca cgataggcgt      120

ttcactttcc aggtgatcat cgatggacgt gagttcccag aaggtgaggg cagatctaag      180

aaagaggcta agaacgctgc tgctaagctc gctgttgaga tcctgaacaa agagaagaag      240

gccgtcagtc cactcctcct gactactact aattcctccg agggactctc catgggaaac      300

tacattggac tcatcaacag gatcgcccag aagaagaggc tcaccgttaa ctacgagcaa      360

gtggcttctg gtgttcatgg accagaggga ttccactaca aggtgaagat gggccagaaa      420

gagtactcca tcggaactgg ctctaccaag caagaggcaa agcaactggc tgccaaactt      480

gcttacctcc agattctttc cgag                                             504


<210>  23
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gly linker heavy chain

<400>  23
gggcccggtg gaggaggctc tggtggaggc ggtagcggag gcggagggtc t                51


<210>  24
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gly linker light chain

<400>  24
ggtggaggag gctctggtgg aggcggtagc ggaggcggag ggtct                       45


<210>  25
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of Cetuximab Heavy Chain with apoplast 
       signal peptide

<400>  25
atggctagga agtcccttat tttcccagtg atccttctcg ccgtgctcct tttttctcca       60

ccaatctact ctgctggcca cgattacagg gatgctctcc gtaaatcttc catggctcag      120

gtgcagctta agcagtctgg accaggactt gttcagcctt ctcagtccct ctccattact      180

tgcactgtgt ccggattctc cctcaccaat tacggtgttc actgggtgag acagtctcca      240

ggtaagggtc ttgaatggct cggagtgatt tggtccggtg gcaacactga ttacaacacc      300

ccattcacct ccaggctctc catcaacaag gacaactcca agagccaggt gttcttcaag      360

atgaactccc tccagtccaa cgacaccgct atctattatt gcgctagggc tctcacctac      420

tacgactacg agtttgctta ctggggacag ggaactctcg ttactgtttc cgctgcttct      480

accaagggac catctgtttt tccactcgct cccagctcta agtccacttc tggtggaact      540

gctgctcttg gatgcctcgt gaaggattac tttccagagc cagtgaccgt gtcctggaac      600

tctggtgctc ttacttcagg cgttcacact ttcccagctg tgcttcaatc ttccggactc      660

tactctctct cctctgttgt gactgtgccc tcttcttcac tcggcactca aacctacatc      720

tgcaacgtga accacaagcc atccaacacc aaggtggaca agaaggtcga gccaaagtcc      780

tgcgataaga ctcatacttg cccaccatgt ccagctccag aacttcttgg tggtccatcc      840

gttttcttgt tcccaccaaa gccaaaggac accctcatga tctctaggac tccagaggtt      900

acatgcgtgg tggttgatgt gtctcatgaa gatcctgagg tgaagttcaa ctggtacgtt      960

gacggtgttg aggtgcacaa cgctaagact aagccacgtg aggaacagta caactccacc     1020

tacagggttg tgtctgtgct tactgtgttg caccaggatt ggctcaacgg caaagagtac     1080

aagtgcaagg tgtccaacaa ggctctccct gctccaatcg aaaagaccat ctctaaggct     1140

aagggccagc caagagagcc acaggtttac actcttccac catccaggga cgagctgacc     1200

aagaatcagg tttcccttac ttgcctggtg aagggcttct acccatccga tattgctgtt     1260

gagtgggagt ctaatggcca gcctgagaac aactacaaga ctactccacc agtgctcgac     1320

tccgatggct cattcttctt gtactccaag ctcaccgtgg acaagtctag atggcagcag     1380

ggaaacgtgt tcagctgctc tgttatgcat gaggcccttc acaaccacta cacccagaag     1440

tccttgtctt tgtctccagg caaggggccc taa                                  1473


<210>  26
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of Cetuximab Light Chain with apoplast 
       signal peptide

<400>  26
atggccgcta ggaagtccct tattttccca gtgattctcc tcgccgtgct ccttttttct       60

ccaccaatct actccgacat cctgctcact cagtctccag tgatcctttc tgtttcccca      120

ggtgagaggg tgtcattttc ttgcagggct tcccagtcca tcggcactaa cattcattgg      180

tatcagcaga ggaccaacgg ctctccaagg ctccttatta agtacgcctc cgagtccatc      240

tccggcattc catctagatt ctccggatct ggctccggca ctgatttcac cctttccatc      300

aactccgttg agtccgagga tatcgctgac tactactgcc agcagaacaa caactggcca      360

actactttcg gagctggcac caagttggag cttaagagaa ctgttgctgc cccatccgtg      420

ttcatcttcc caccatctga tgagcagctc aagtccggaa ctgcttctgt tgtgtgcctc      480

ctcaacaact tctacccaag ggaagctaag gtgcagtgga aggttgacaa tgctctccag      540

tccggaaact cccaagagtc agttacagag caggactcca aggactctac ctacagcctc      600

agctctactc tcactctcag caaggctgat tacgagaagc acaaggtgta cgcttgcgag      660

gttacacacc agggactttc ttcaccagtg accaagtctt tcaacagggg agagtgt         717


<210>  27
<211>  1272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of dsRBD-linker- Cetuximab Light Chain with
       apoplast signal peptide

<400>  27
atggccgcta ggaagtccct tattttccca gtgattctcc tcgccgtgct ccttttttct       60

ccaccaatct actccatgat ggctggtgat ctttccgctg gcttcttcat ggaagagttg      120

aacacctaca ggcaaaagca gggcgttgtg ctcaagtacc aagagcttcc aaattccgga      180

ccaccacacg ataggcgttt cactttccag gtgatcatcg atggacgtga gttcccagaa      240

ggtgagggca gatctaagaa agaggctaag aacgctgctg ctaagctcgc tgttgagatc      300

ctgaacaaag agaagaaggc cgtcagtcca ctcctcctga ctactactaa ttcctccgag      360

ggactctcca tgggaaacta cattggactc atcaacagga tcgcccagaa gaagaggctc      420

accgttaact acgagcaagt ggcttctggt gttcatggac cagagggatt ccactacaag      480

gtgaagatgg gccagaaaga gtactccatc ggaactggct ctaccaagca agaggcaaag      540

caactggctg ccaaacttgc ttacctccag attctttccg agggtggagg aggctctggt      600

ggaggcggta gcggaggcgg agggtctgac atcctgctca ctcagtctcc agtgatcctt      660

tctgtttccc caggtgagag ggtgtcattt tcttgcaggg cttcccagtc catcggcact      720

aacattcatt ggtatcagca gaggaccaac ggctctccaa ggctccttat taagtacgcc      780

tccgagtcca tctccggcat tccatctaga ttctccggat ctggctccgg cactgatttc      840

accctttcca tcaactccgt tgagtccgag gatatcgctg actactactg ccagcagaac      900

aacaactggc caactacttt cggagctggc accaagttgg agcttaagag aactgttgct      960

gccccatccg tgttcatctt cccaccatct gatgagcagc tcaagtccgg aactgcttct     1020

gttgtgtgcc tcctcaacaa cttctaccca agggaagcta aggtgcagtg gaaggttgac     1080

aatgctctcc agtccggaaa ctcccaagag tcagttacag agcaggactc caaggactct     1140

acctacagcc tcagctctac tctcactctc agcaaggctg attacgagaa gcacaaggtg     1200

tacgcttgcg aggttacaca ccagggactt tcttcaccag tgaccaagtc tttcaacagg     1260

ggagagtgtt ga                                                         1272


<210>  28
<211>  2025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of Cetuximab Heavy Chain with apoplast 
       signal peptide - linker - dsRBD

<400>  28
atggctagga agtcccttat tttcccagtg atccttctcg ccgtgctcct tttttctcca       60

ccaatctact ctgctggcca cgattacagg gatgctctcc gtaaatcttc catggctcag      120

gtgcagctta agcagtctgg accaggactt gttcagcctt ctcagtccct ctccattact      180

tgcactgtgt ccggattctc cctcaccaat tacggtgttc actgggtgag acagtctcca      240

ggtaagggtc ttgaatggct cggagtgatt tggtccggtg gcaacactga ttacaacacc      300

ccattcacct ccaggctctc catcaacaag gacaactcca agagccaggt gttcttcaag      360

atgaactccc tccagtccaa cgacaccgct atctattatt gcgctagggc tctcacctac      420

tacgactacg agtttgctta ctggggacag ggaactctcg ttactgtttc cgctgcttct      480

accaagggac catctgtttt tccactcgct cccagctcta agtccacttc tggtggaact      540

gctgctcttg gatgcctcgt gaaggattac tttccagagc cagtgaccgt gtcctggaac      600

tctggtgctc ttacttcagg cgttcacact ttcccagctg tgcttcaatc ttccggactc      660

tactctctct cctctgttgt gactgtgccc tcttcttcac tcggcactca aacctacatc      720

tgcaacgtga accacaagcc atccaacacc aaggtggaca agaaggtcga gccaaagtcc      780

tgcgataaga ctcatacttg cccaccatgt ccagctccag aacttcttgg tggtccatcc      840

gttttcttgt tcccaccaaa gccaaaggac accctcatga tctctaggac tccagaggtt      900

acatgcgtgg tggttgatgt gtctcatgaa gatcctgagg tgaagttcaa ctggtacgtt      960

gacggtgttg aggtgcacaa cgctaagact aagccacgtg aggaacagta caactccacc     1020

tacagggttg tgtctgtgct tactgtgttg caccaggatt ggctcaacgg caaagagtac     1080

aagtgcaagg tgtccaacaa ggctctccct gctccaatcg aaaagaccat ctctaaggct     1140

aagggccagc caagagagcc acaggtttac actcttccac catccaggga cgagctgacc     1200

aagaatcagg tttcccttac ttgcctggtg aagggcttct acccatccga tattgctgtt     1260

gagtgggagt ctaatggcca gcctgagaac aactacaaga ctactccacc agtgctcgac     1320

tccgatggct cattcttctt gtactccaag ctcaccgtgg acaagtctag atggcagcag     1380

ggaaacgtgt tcagctgctc tgttatgcat gaggcccttc acaaccacta cacccagaag     1440

tccttgtctt tgtctccagg caaggggccc ggtggaggag gctctggtgg aggcggtagc     1500

ggaggcggag ggtctatgat ggctggtgat ctttccgctg gcttcttcat ggaagagttg     1560

aacacctaca ggcaaaagca gggcgttgtg ctcaagtacc aagagcttcc aaattccgga     1620

ccaccacacg ataggcgttt cactttccag gtgatcatcg atggacgtga gttcccagaa     1680

ggtgagggca gatctaagaa agaggctaag aacgctgctg ctaagctcgc tgttgagatc     1740

ctgaacaaag agaagaaggc cgtcagtcca ctcctcctga ctactactaa ttcctccgag     1800

ggactctcca tgggaaacta cattggactc atcaacagga tcgcccagaa gaagaggctc     1860

accgttaact acgagcaagt ggcttctggt gttcatggac cagagggatt ccactacaag     1920

gtgaagatgg gccagaaaga gtactccatc ggaactggct ctaccaagca agaggcaaag     1980

caactggctg ccaaacttgc ttacctccag attctttccg agtga                     2025


