                         SEQUENCE LISTING

<110>  St Vincent's Institute of Medical Research
 
<120>  Multi-specific antibodies

<130>  53022685

<150>  AU2018900778
<151>  2018-03-09

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  2
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly 
        435                 440 


<210>  3
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  4
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro Val His Gly 
1               5                   10                  15      


Tyr Trp 
        


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Tyr Gly Met His 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Ile Trp Phe Asp Gly Thr Lys Lys Tyr Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Arg Gly Ile Gly Ala Arg Arg Gly Pro Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  8
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  11
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser 
            20                  25                  30  


<210>  12
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  12

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  13
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  14
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  14

Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  17
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  18
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  19
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Phe Asp Gly Thr Lys Lys Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ile Gly Ala Arg Arg Gly Pro Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  20
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  21
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  21
caggtgcagc tggtggagtc cggaggagga gtggtgcagc caggccggtc cctgagactg       60

tcttgtgccg ccagcggctt cgcctttagc tcctatggca tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccgtg atctggttcg acggcaccaa gaagtactat      180

acagatagcg tgaagggcag gtttaccatc tcccgcgaca actctaagaa tacactgtac      240

ctccagatga ataccctgcg cgccgaggac acagccgtgt actattgcgc cagggatcgc      300

ggaatcggcg ccagaagagg accttactat atggacgtgt ggggcaaggg caccacagtg      360

accgtgtcta gc                                                          372


<210>  22
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  22
gacatccaga tgacccagag cccaagctcc ctgtctgcaa gtgtgggcga tcgggtcacc       60

atcacatgta gagcctcaca gagcatttct agttacctga actggtatca gcagaagcca      120

gggaaagctc ccaagctgct gatctacgcc gcttcaagcc tgcagtctgg agtgcccagt      180

cgattctccg gctctgggag tggaacagac tttactctga ccatttcctc tctgcagcct      240

gaggatttcg ccacttacta ttgccagcag tcatatagca ccccactgac atttggcggg      300

ggaacaaaag tggagatcaa g                                                321


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Tyr Phe Thr Asp Tyr Asn Met His 
1               5                   


<210>  24
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  24

Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Arg Pro Ala Met Asp Tyr 
1               5           


<210>  26
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  27
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  29
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  30
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  30

Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  31
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr Met Asp 
1               5                   10                  15      


Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  32
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  32

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  33
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  33

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  35
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
1               5                   10                  15      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys 
            20                  25                  30          


<210>  36
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  36

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  37
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  38
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  38

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  39
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  39
gaggtgcagc tgcagcagag cggacctgag ctggtgaagc caggagccag cgtgaagatc       60

agctgcaagg cctctggcta taccttcaca gactacaaca tgcactgggt gaagcagagc      120

cacggcaagt ccctggagtg gatcggctac atctatccct acaacggcgg caccggctat      180

aatcagaagt ttaagtccaa ggccaccctg acagtggaca atagctcctc taccgcctac      240

atggacgtgc gctccctgac atctgaggat agcgccgtgt actattgtgc ccggggcaga      300

cctgctatgg actattgggg acagggcacc agcgtgaccg tgagcagc                   348


<210>  40
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  40
gacatcgtgc tgacccagtc tccagccagc ctggccgtgt ccctgggaca gagggccacc       60

atctcttgta gagccagcga gtccgtggat aactacggca tctccttcat gaattggttt      120

cagcagaagc ccggccagcc ccctaagctg ctgatctatg cagccagcaa ccagggctcc      180

ggcgtgccag cccggttctc tggcagcggc tccggcaccg acttcagcct gaacatccac      240

cctatggagg aggacgatac agccatgtat ttctgccagc agtccaagga ggtgccttgg      300

acctttggcg gcggcacaaa gctggagatc aag                                   333


<210>  41
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Phe Asp Phe Ser Arg Tyr Trp Met Asn 
1               5                   10  


<210>  42
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  43
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Met Gly Tyr Trp Gly 
1               5       


<210>  44
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  45

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Gln Tyr Arg Lys Leu Pro Tyr Thr 
1               5                   


<210>  47
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  47

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser 
            20                  25  


<210>  48
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  48

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  49
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  49

Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Lys Val Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  50
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   


<210>  51
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  52
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  52

Trp Phe Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  53
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  54
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  54

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  55
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X can be either L or I

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  X can be either L or I

<400>  55

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Xaa Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Met Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  56
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  56

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  57
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  57
gaggtgaagc tgctggagtc cggaggaggc ctggtgcagc ctggaggctc cctgaagctg       60

tcttgtgccg ccagcggctt cgacttttct aggtactgga tgaactgggt gcgccaggca      120

ccaggcaagg gcctggagtg gatcggcagg atcaacccag atagctccac catcaattac      180

acaccctccc tgaaggacaa gtttatcatc tctcgcgata acgccaagaa taccctgtat      240

ctgcagatgt ccaaggtgcg gtctgaggac acagccctgt actattgcgc cagacagatg      300

ggctattggg gccagggcac cacactgacc gtgtctagc                             339


<210>  58
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  58
gatattcaga tgactcagac tacttcttcc ctgtctgcaa gtctggggga ccgagtgaca       60

atctcatgca gcgcctccca gggaatttcc aactacctga attggttcca gcagaagcct      120

gatggcacag tgaaactgct gatctactat actagctccc tgcacagtgg ggtcccatca      180

agattttctg gaagtggctc agggaccgac tatagcctga caatctccaa cctggagcca      240

gaagatattg ccacttacta ttgccagcag taccggaagc tgccctatac tttcggcggg      300

ggaaccaagc tggagatcaa a                                                321


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Phe Thr Phe Arg Thr Tyr Gly Met Ser 
1               5                   10  


<210>  60
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  60

Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Ala Asp Asn Val Arg 
1               5                   10                  15      


Glu 
    


<210>  61
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  61

Arg Tyr Gly Tyr Asp Gly Gly Gly Ser Phe Asp Val 
1               5                   10          


<210>  62
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  62

Arg Ser Asn Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Cys 
1               5                   10                  15      


<210>  63
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  63

Arg Met Ser Thr Leu Ala Pro 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Gln His Ile Glu Tyr Pro Leu Thr 
1               5                   


<210>  65
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  66
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  66

Trp Val Arg Gln Thr Ala Asp Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  67
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  67

Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asp Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Arg Leu Glu Ser Asp Asp Thr Ala Met Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  68
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  68

Trp Gly Ala Gly Thr Arg Val Thr Val Ser Ser 
1               5                   10      


<210>  69
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  69

Glu Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys 
            20              


<210>  70
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  70

Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  71
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  71

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr 
1               5                   10                  15      


Leu Arg Ile Ser Arg Leu Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  72
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  72

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  73
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Ala Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Ala Asp Asn Val 
    50                  55                  60                  


Arg Glu Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Glu Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Tyr Gly Tyr Asp Gly Gly Gly Ser Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Arg Val Thr Val Ser Ser 
        115                 120     


<210>  74
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  74

Glu Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Asn Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Cys Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Thr Leu Ala Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Ile Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  75
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  75
gaagtccaac tggtcgaatc aggtggcgat ctggtccgtc cgggcggtag cctgaaactg       60

tcttgcgcgg ccagtggctt taccttccgc acgtatggta tgtcatgggt gcgtcagacc      120

gcggataaac gcctggaatg ggttgccacc attagcagcg gcggcaccta tacgtattac      180

gcagacaacg tgcgtgaacg ctttaccatc tctcgtgata atgctcgcga cacgctgtac      240

ctgcaaatgt cccgcctgga atcagatgac accgcgatgt attactgtac gcgtcgctat      300

ggctacgatg gcggtggcag tttcgacgtc tggggtgcag gcacccgtgt gaccgttagt      360

tcc                                                                    363


<210>  76
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  76
gaaattgtta tgacccaggc agctccgtca gtcccggtga cgccgggtga atcagcgtcg       60

atcagctgcc gttcaaacaa atcgctgctg cattcgaacg gcaataccta tctgtgttgg      120

tttctgcaac gtccgggtca gagtccgcaa ctgctgattt accgtatgtc caccctggcc      180

ccgggcgttc cggatcgttt ttctggtagt ggctccggca ccgcgttcac gctgcgtatc      240

agccgcctgg aagccgaaga tgttggtgtc tattactgta tgcaacacat tgaatatccg      300

ctgacctttg gcgctggcac gaaactggaa ctgaaa                                336


<210>  77
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  77

Gly Phe Asp Phe Glu Lys Ala Trp Met Ser 
1               5                   10  


<210>  78
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  78

Arg Ile Lys Ser Thr Ala Asp Gly Gly Thr Thr Ser Tyr Ala Ala Pro 
1               5                   10                  15      


Val Glu Gly 
            


<210>  79
<211>  2
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala His 
1       


<210>  80
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  80

Ser Gly Glu Ala Leu Pro Met Gln Phe Ala His 
1               5                   10      


<210>  81
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  81

Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210>  82
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  82

Gln Ser Pro Asp Ser Thr Asn Thr Tyr Glu Val 
1               5                   10      


<210>  83
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  83

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser 
            20                  25  


<210>  84
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  84

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val Ala 
1               5                   10                  


<210>  85
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  85

Arg Phe Ile Ile Ser Arg Asp Asp Ser Arg Asn Met Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ser 
            20                  25                  30          


<210>  86
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  86

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  87
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys 
            20          


<210>  88
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  88

Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Val Ile Val Val Tyr 
1               5                   10                  15  


<210>  89
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  89

Gly Val Pro Glu Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  90
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  90

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  91
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  91

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp Phe Glu Lys Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Arg Ile Lys Ser Thr Ala Asp Gly Gly Thr Thr Ser Tyr Ala Ala 
    50                  55                  60                  


Pro Val Glu Gly Arg Phe Ile Ile Ser Arg Asp Asp Ser Arg Asn Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  92
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Glu Ala Leu Pro Met Gln Phe Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Val Ile Val Val Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Val Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Pro Asp Ser Thr Asn Thr Tyr 
                85                  90                  95      


Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  93
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  93
gaggtgcagc tggtgcagtc cggaggaggc ctggtggagc caggaggctc tctgaggctg       60

agctgtgccg tgtccggctt cgactttgag aaggcctgga tgtcttgggt gcggcaggca      120

ccaggacagg gcctgcagtg ggtggccaga atcaagtcta ccgccgatgg aggcaccaca      180

agctacgccg caccagtgga gggccgcttc atcatctctc gggacgatag cagaaacatg      240

ctgtatctgc agatgaacag cctgaaaacc gaggacacag ccgtgtacta ttgcacctcc      300

gcccactggg gacagggcac cctggtgacc gtgagcagc                             339


<210>  94
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  94
cagtccgtgc tgacccagcc accttccgtg tctgtgagcc caggccagac agcaaggatc       60

acctgttccg gagaggccct gccaatgcag ttcgcacact ggtatcagca gaggccaggc      120

aaggcccccg tgatcgtggt gtacaaggat tctgagaggc ctagcggcgt gccagagcgg      180

ttcagcggct ctagctccgg caccacagcc accctgacaa tcaccggagt gcaggcagag      240

gacgaggcag attactattg tcagtccccc gactctacaa acacctacga ggtgttcgga      300

ggaggcacaa agctgaccgt gctg                                             324


<210>  95
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  95

Gly Ser Gly Ser Gly 
1               5   


<210>  96
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  96
ggctccggct ctggc                                                        15


