                         SEQUENCE LISTING

<110>  UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
 
<120>  DRUG STABILIZED THERAPEUTIC TRANSGENES DELIVERED BY 
       ADENO-ASSOCIATED VIRUS EXPRESSION

<130>  U1197.70133WO00

<140>  NOT YET ASSIGNED
<141>  2019-03-02

<150>  US 62/637485
<151>  2018-03-02

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
atgaaggtct tggcggcagg agttgtgccc ctgctgttgg ttctgcactg gaaacatggg       60

gcggggagcc ccctccccat cacccctgtc aacgccacct gtgccatacg ccacccatgt      120

cacaacaacc tcatgaacca gatcaggagc caactggcac agctcaatgg cagtgccaat      180

gccctcttta ttctctatta cacagcccag ggggagccgt tccccaacaa cctggacaag      240

ctatgtggcc ccaacgtgac ggacttcccg cccttccacg ccaacggcac ggagaaggcc      300

aagctggtgg agctgtaccg catagtcgtg taccttggca cctccctggg caacatcacc      360

cgggaccaga agatcctcaa ccccagtgcc ctcagcctcc acagcaagct caacgccacc      420

gccgacatcc tgcgaggcct ccttagcaac gtgctgtgcc gcctgtgcag caagtaccac      480

gtgggccatg tggacgtgac ctacggccct gacacctcgg gtaaggatgt cttccagaag      540

aagaagctgg gctgtcaact cctggggaag tataagcaga tcatcgccgt gttggcccag      600

gccttctag                                                              609


<210>  2
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 
1               5                   10                  15      


Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 
            20                  25                  30          


Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 
        35                  40                  45              


Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 
    50                  55                  60                  


Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 
65                  70                  75                  80  


Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 
                85                  90                  95      


Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 
            100                 105                 110         


Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 
        115                 120                 125             


Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 
    130                 135                 140                 


Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 
145                 150                 155                 160 


Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 
                165                 170                 175     


Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 
            180                 185                 190         


Gln Ile Ile Ala Val Leu Ala Gln Ala Phe 
        195                 200         


<210>  3
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
atgaaagtgc tggctgccgg cgtggttcct ctgctgctgg tacttcactg gaagcacggt       60

gccggctcac cactccccat caccccagta aacgcgacct gcgctattag acacccatgt      120

cacaacaacc tgatgaacca gattcgctcc caactggccc agctgaacgg gagtgctaat      180

gctctgttca tcttgtatta cacagcccaa ggagaaccct ttcccaataa ccttgataaa      240

ctgtgcggcc ccaatgtgac cgatttcccc cccttccatg ctaacgggac ggagaaagct      300

aaactggtcg agctgtaccg gatagttgtg tacttgggca catcactcgg caacattaca      360

cgggatcaga agatcctgaa cccttctgcc ctttctttgc atagcaagct gaacgccacg      420

gctgacatac tgaggggtct gctttctaat gtgttgtgcc ggctttgctc taagtaccat      480

gtaggccatg tagatgtgac gtacggtccg gatacttcag ggaaagacgt attccagaaa      540

aagaagttgg ggtgccagct gctggggaaa tataagcaga tcatagccgt tctggcccag      600

gcttttacca gatctcgcaa gaagcgcagc accagatctc gcaagaagcg cagcggggcc      660

cccatgatat ctctgatcgc tgctcttgct gtggactacg tgattggtat ggagaatgct      720

atgccctgga atctgcctgc agacctggca tggtttaaga ggaacaccct taataaacct      780

gtaatcatgg gacgacatac atgggagagt atcggcaggc cattgcccgg gaggaagaat      840

ataattctga gttcccagcc ttctactgat gatagggtaa cttgggtcaa gagcgtcgac      900

gaggccatcg ccgcttgcgg ggatgtgcct gaaatcatgg ttatcggggg cggacgggtg      960

attgagcaat ttctgcccaa ggcacagaag ctgtatctga cccatataga cgccgaggtg     1020

gagggagata cacactttcc cgactatgag cccgatgatt gggagagtgt ctttagcgaa     1080

tttcatgacg ccgacgcaca gaattcccat agctactgct tcgaaattct cgaacggcgc     1140

tag                                                                   1143


<210>  4
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 
1               5                   10                  15      


Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 
            20                  25                  30          


Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 
        35                  40                  45              


Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 
    50                  55                  60                  


Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 
65                  70                  75                  80  


Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 
                85                  90                  95      


Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 
            100                 105                 110         


Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 
        115                 120                 125             


Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 
    130                 135                 140                 


Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 
145                 150                 155                 160 


Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 
                165                 170                 175     


Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 
            180                 185                 190         


Gln Ile Ile Ala Val Leu Ala Gln Ala Phe Thr Arg Ser Arg Lys Lys 
        195                 200                 205             


Arg Ser Thr Arg Ser Arg Lys Lys Arg Ser Gly Ala Pro Met Ile Ser 
    210                 215                 220                 


Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu Asn Ala 
225                 230                 235                 240 


Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr 
                245                 250                 255     


Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly 
            260                 265                 270         


Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Ser 
        275                 280                 285             


Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala 
    290                 295                 300                 


Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val 
305                 310                 315                 320 


Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile 
                325                 330                 335     


Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu Pro Asp 
            340                 345                 350         


Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn 
        355                 360                 365             


Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
    370                 375                 380 


<210>  5
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe Thr Arg Ser Arg 
225                 230                 235                 240 


Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys Arg Ser Gly Ala Pro Met 
                245                 250                 255     


Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu 
            260                 265                 270         


Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg 
        275                 280                 285             


Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser 
    290                 295                 300                 


Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln 
305                 310                 315                 320 


Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala 
                325                 330                 335     


Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly 
            340                 345                 350         


Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr 
        355                 360                 365             


His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu 
    370                 375                 380                 


Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala 
385                 390                 395                 400 


Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
                405                 410                 


<210>  6
<211>  3540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catggagtct tctgctaaaa tggaaagcgg aggagcaggt cagcagccgc agccacagcc     1980

ccaacagccg tttctccctc cggccgcatg ctttttcgca acagcagccg cagctgcggc     2040

cgctgccgct gctgctgccg ctcaatcagc ccaacagcag caacaacaac agcaacagca     2100

gcaacaggcc ccacaactga gaccagcagc tgacgggcaa ccctcagggg gtggacataa     2160

gagtgcccca aagcaagtta agcgccaacg ctcaagttcc ccggagctga tgcggtgtaa     2220

gagacgcctg aactttagcg ggttcggcta cagcctgccc caacagcaac cagcagccgt     2280

agccaggaga aatgaaaggg agcgcaatcg ggttaagctc gtcaacctcg gcttcgcaac     2340

tctgcgcgaa cacgtcccaa atggagcggc taacaagaaa atgagtaaag ttgagactct     2400

ccgcagtgct gtcgaatata ttcgggcgct tcaacaactt ctcgatgagc acgatgcagt     2460

gtctgccgcg tttcaggccg gggtcttgtc tccgaccatt tccccgaact actccaatga     2520

cctgaactct atggcaggtt ctcccgtctc ttcctattct tctgatgaag gctcatacga     2580

tcctctgagt cctgaggaac aggaattgtt ggatttcacg aactggttca ccagatctcg     2640

caagaagcgc agcaccagat ctcgcaagaa gcgcagcggg gcccccatga tatctctgat     2700

cgctgctctt gctgtggact acgtgattgg tatggagaat gctatgccct ggaatctgcc     2760

tgcagacctg gcatggttta agaggaacac ccttaataaa cctgtaatca tgggacgaca     2820

tacatgggag agtatcggca ggccattgcc cgggaggaag aatataattc tgagttccca     2880

gccttctact gatgataggg taacttgggt caagagcgtc gacgaggcca tcgccgcttg     2940

cggggatgtg cctgaaatca tggttatcgg gggcggacgg gtgattgagc aatttctgcc     3000

caaggcacag aagctgtatc tgacccatat agacgccgag gtggagggag atacacactt     3060

tcccgactat gagcccgatg attgggagag tgtctttagc gaatttcatg acgccgacgc     3120

acagaattcc catagctact gcttcgaaat tctcgaacgg cgctaggcgg ccgcgcggat     3180

ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa     3240

aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc     3300

aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg     3360

tgggaggttt tttagtcgac tggggagaga tctgaggaac ccctagtgat ggagttggcc     3420

actccctctc tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg     3480

gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaac     3540


<210>  7
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Ala Phe Thr Glu His Ser Pro Leu Thr Pro His Arg Arg Asp Leu 
1               5                   10                  15      


Cys Ser Arg Ser Ile Trp Leu Ala Arg Lys Ile Arg Ser Asp Leu Thr 
            20                  25                  30          


Ala Leu Thr Glu Ser Tyr Val Lys His Gln Gly Leu Asn Lys Asn Ile 
        35                  40                  45              


Asn Leu Asp Ser Ala Asp Gly Met Pro Val Ala Ser Thr Asp Gln Trp 
    50                  55                  60                  


Ser Glu Leu Thr Glu Ala Glu Arg Leu Gln Glu Asn Leu Gln Ala Tyr 
65                  70                  75                  80  


Arg Thr Phe His Val Leu Leu Ala Arg Leu Leu Glu Asp Gln Gln Val 
                85                  90                  95      


His Phe Thr Pro Thr Glu Gly Asp Phe His Gln Ala Ile His Thr Leu 
            100                 105                 110         


Leu Leu Gln Val Ala Ala Phe Ala Tyr Gln Ile Glu Glu Leu Met Ile 
        115                 120                 125             


Leu Leu Glu Tyr Lys Ile Pro Arg Asn Glu Ala Asp Gly Met Pro Ile 
    130                 135                 140                 


Asn Val Gly Asp Gly Gly Leu Phe Glu Lys Lys Leu Trp Gly Leu Lys 
145                 150                 155                 160 


Val Leu Gln Glu Leu Ser Gln Trp Thr Val Arg Ser Ile His Asp Leu 
                165                 170                 175     


Arg Phe Ile Ser Ser His Gln Thr Gly Ile Pro Ala Arg Gly Ser His 
            180                 185                 190         


Tyr Ile Ala Asn Asn Lys Lys Met Thr Arg Ser Arg Lys Lys Arg Ser 
        195                 200                 205             


Thr Arg Ser Arg Lys Lys Arg Ser Gly Ala Pro Met Ile Ser Leu Ile 
    210                 215                 220                 


Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu Asn Ala Met Pro 
225                 230                 235                 240 


Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu Asn 
                245                 250                 255     


Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly Arg Pro 
            260                 265                 270         


Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Ser Thr Asp 
        275                 280                 285             


Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala Ala Cys 
    290                 295                 300                 


Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val Ile Glu 
305                 310                 315                 320 


Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile Asp Ala 
                325                 330                 335     


Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu Pro Asp Asp Trp 
            340                 345                 350         


Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn Ser His 
        355                 360                 365             


Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
    370                 375             


<210>  8
<211>  3432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catggccttt actgagcata gccccttgac accgcacaga agggatcttt gctccaggtc     1980

catctggctc gcacggaaga tcaggtcaga cctgacagcc ctgaccgaat catatgtaaa     2040

gcaccagggc ctgaataaaa acattaacct cgacagcgca gacggaatgc cggtggcctc     2100

aacagatcag tggtccgaac tgacggaggc ggagcggttg caagaaaact tgcaggcgta     2160

tcgaacgttt cacgtcctgc ttgcccggct tcttgaagac cagcaggttc atttcacgcc     2220

tacagaggga gatttccatc aagcaatcca cactttgctc ctgcaagtcg cggcctttgc     2280

ctatcagatt gaggaactca tgattcttct cgaatataag attccacgga atgaggcgga     2340

tgggatgccg attaacgtgg gcgacggagg gttgtttgag aaaaaactct ggggtttgaa     2400

agttctgcaa gaattgagtc agtggactgt gcgatctatc cacgacttga ggttcatctc     2460

atcccatcaa acagggatac ctgcaagagg ctctcattat atagcgaata ataaaaaaat     2520

gaccagatct cgcaagaagc gcagcaccag atctcgcaag aagcgcagcg gggcccccat     2580

gatatctctg atcgctgctc ttgctgtgga ctacgtgatt ggtatggaga atgctatgcc     2640

ctggaatctg cctgcagacc tggcatggtt taagaggaac acccttaata aacctgtaat     2700

catgggacga catacatggg agagtatcgg caggccattg cccgggagga agaatataat     2760

tctgagttcc cagccttcta ctgatgatag ggtaacttgg gtcaagagcg tcgacgaggc     2820

catcgccgct tgcggggatg tgcctgaaat catggttatc gggggcggac gggtgattga     2880

gcaatttctg cccaaggcac agaagctgta tctgacccat atagacgccg aggtggaggg     2940

agatacacac tttcccgact atgagcccga tgattgggag agtgtcttta gcgaatttca     3000

tgacgccgac gcacagaatt cccatagcta ctgcttcgaa attctcgaac ggcgctaggc     3060

ggccgcgcgg atccagacat gataagatac attgatgagt ttggacaaac cacaactaga     3120

atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc     3180

attataagct gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt     3240

cagggggagg tgtgggaggt tttttagtcg actggggaga gatctgagga acccctagtg     3300

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag     3360

cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag     3420

ggagtggcca ac                                                         3432


<210>  9
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met 
1               5                   10                  15      


Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys 
            20                  25                  30          


Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu 
        35                  40                  45              


Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser 
    50                  55                  60                  


Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu 
65                  70                  75                  80  


Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly 
                85                  90                  95      


Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu 
            100                 105                 110         


Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr 
        115                 120                 125             


Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp 
    130                 135                 140                 


Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg Gly 
145                 150                 155                 160 


Ala Pro Lys Lys Lys Arg Lys Val Ser Asn Leu Leu Thr Val His Gln 
                165                 170                 175     


Asn Leu Pro Ala Leu Pro Val Asp Ala Thr Ser Asp Glu Val Arg Lys 
            180                 185                 190         


Asn Leu Met Asp Met Phe Arg Asp Arg Gln Ala Phe Ser Glu His Thr 
        195                 200                 205             


Trp Lys Met Leu Leu Ser Val Cys Arg Ser Trp Ala Ala Trp Cys Lys 
    210                 215                 220                 


Leu Asn Asn Arg Lys Trp Phe Pro Ala Glu Pro Glu Asp Val Arg Asp 
225                 230                 235                 240 


Tyr Leu Leu Tyr Leu Gln Ala Arg Gly Leu Ala Val Lys Thr Ile Gln 
                245                 250                 255     


Gln His Leu Gly Gln Leu Asn Met Leu His Arg Arg Ser Gly Leu Pro 
            260                 265                 270         


Arg Pro Ser Asp Ser Asn Ala Val Ser Leu Val Met Arg Arg Ile Arg 
        275                 280                 285             


Lys Glu Asn Val Asp Ala Gly Glu Arg Ala Lys Gln Ala Leu Ala Phe 
    290                 295                 300                 


Glu Arg Thr Asp Phe Asp Gln Val Arg Ser Leu Met Glu Asn Ser Asp 
305                 310                 315                 320 


Arg Cys Gln Asp Ile Arg Asn Leu Ala Phe Leu Gly Ile Ala Tyr Asn 
                325                 330                 335     


Thr Leu Leu Arg Ile Ala Glu Ile Ala Arg Ile Arg Val Lys Asp Ile 
            340                 345                 350         


Ser Arg Thr Asp Gly Gly Arg Met Leu Ile His Ile Gly Arg Thr Lys 
        355                 360                 365             


Thr Leu Val Ser Thr Ala Gly Val Glu Lys Ala Leu Ser Leu Gly Val 
    370                 375                 380                 


Thr Lys Leu Val Glu Arg Trp Ile Ser Val Ser Gly Val Ala Asp Asp 
385                 390                 395                 400 


Pro Asn Asn Tyr Leu Phe Cys Arg Val Arg Lys Asn Gly Val Ala Ala 
                405                 410                 415     


Pro Ser Ala Thr Ser Gln Leu Ser Thr Arg Ala Leu Glu Gly Ile Phe 
            420                 425                 430         


Glu Ala Thr His Arg Leu Ile Tyr Gly Ala Lys Asp Asp Ser Gly Gln 
        435                 440                 445             


Arg Tyr Leu Ala Trp Ser Gly His Ser Ala Arg Val Gly Ala Ala Arg 
    450                 455                 460                 


Asp Met Ala Arg Ala Gly Val Ser Ile Pro Glu Ile Met Gln Ala Gly 
465                 470                 475                 480 


Gly Trp Thr Asn Val Asn Ile Val Met Asn Tyr Ile Arg Asn Leu Asp 
                485                 490                 495     


Ser Glu Thr Gly Ala Met Val Arg Leu Leu Glu Asp Gly Asp 
            500                 505                 510 


<210>  10
<211>  3838
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcctgcagg cggccgccgc caccatgatc     1920

tctctgattg ccgctctggc cgtggactac gtgatcggga tggaaaacgc tatgccatgg     1980

aatctgcccg ccgatctggc ttggttcaag aggaacaccc tgaacaagcc agtgatcatg     2040

ggcagacaca cttgggagtc cattggccgg cccctgcctg gacgcaagaa catcattctg     2100

agctcccagc cctctaccga cgacagggtg acatgggtga aaagtgtgga cgaagccatt     2160

gccgcttgcg gagatgtgcc cgagatcatg gtcatcggcg gagggagagt gatcgagcag     2220

ttcctgccta aggcccagaa actgtacctg actcacattg acgctgaggt ggaaggggac     2280

acccattttc ctgattatga gccagacgat tgggaaagcg tgttctccga gtttcacgac     2340

gccgatgctc agaattctca tagttattgc tttgagatcc tggaaaggag aggcgcgcct     2400

aagaagaaga ggaaggtgtc caatttactg accgtacacc aaaatttgcc tgcattaccg     2460

gtcgatgcaa cgagtgatga ggttcgcaag aacctgatgg acatgttcag ggatcgccag     2520

gcgttttctg agcatacctg gaaaatgctt ctgtccgttt gccggtcgtg ggcggcatgg     2580

tgcaagttga ataaccggaa atggtttccc gcagaacctg aagatgttcg cgattatctt     2640

ctatatcttc aggcgcgcgg tctggcagta aaaactatcc agcaacattt gggccagcta     2700

aacatgcttc atcgtcggtc cgggctgcca cgaccaagtg acagcaatgc tgtttcactg     2760

gttatgcggc ggatccgaaa agaaaacgtt gatgccggtg aacgtgcaaa acaggctcta     2820

gcgttcgaac gcactgattt cgaccaggtt cgttcactca tggaaaatag cgatcgctgc     2880

caggatatac gtaatctggc atttctgggg attgcttata acaccctgtt acgtatagcc     2940

gaaattgcca ggatcagggt taaagatatc tcacgtactg acggtgggag aatgttaatc     3000

catattggca gaacgaaaac gctggttagc accgcaggtg tagagaaggc acttagcctg     3060

ggggtaacta aactggtcga gcgatggatt tccgtctctg gtgtagctga tgatccgaat     3120

aactacctgt tttgccgggt cagaaaaaat ggtgttgccg cgccatctgc caccagccag     3180

ctatcaactc gcgccctgga agggattttt gaagcaactc atcgattgat ttacggcgct     3240

aaggatgact ctggtcagag atacctggcc tggtctggac acagtgcccg tgtcggagcc     3300

gcgcgagata tggcccgcgc tggagtttca ataccggaga tcatgcaagc tggtggctgg     3360

accaatgtaa atattgtcat gaactatatc cgtaacctgg atagtgaaac aggggcaatg     3420

gtgcgcctgc tggaagatgg cgattaggtc gactagagct cgctgatcag cctcgactgt     3480

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga     3540

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag     3600

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     3660

agacaatagc aggcatgctg gggagagatc tgaggaaccc ctagtgatgg agttggccac     3720

tccctctctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc     3780

gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaac       3838


<210>  11
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Val Ser Val Pro Thr Thr Trp Cys Ser Val Ala Leu Ala Leu Leu 
1               5                   10                  15      


Val Ala Leu His Glu Gly Lys Gly Gln Ala Ala Ala Thr Leu Glu Gln 
            20                  25                  30          


Pro Ala Ser Ser Ser His Ala Gln Gly Thr His Leu Arg Leu Arg Arg 
        35                  40                  45              


Cys Ser Cys Ser Ser Trp Leu Asp Lys Glu Cys Val Tyr Phe Cys His 
    50                  55                  60                  


Leu Asp Ile Ile Trp Val Asn Thr Pro Glu Gln Thr Ala Pro Tyr Gly 
65                  70                  75                  80  


Leu Gly Asn Pro Pro Arg Arg Arg Arg Arg Ser Leu Pro Arg Arg Cys 
                85                  90                  95      


Gln Cys Ser Ser Ala Arg Asp Pro Ala Cys Ala Thr Phe Cys Leu Arg 
            100                 105                 110         


Arg Pro Trp Thr Glu Ala Gly Ala Val Pro Ser Arg Lys Ser Pro Ala 
        115                 120                 125             


Asp Val Phe Gln Thr Gly Lys Thr Gly Ala Thr Thr Gly Glu Leu Leu 
    130                 135                 140                 


Gln Arg Leu Arg Asp Ile Ser Thr Val Lys Ser Leu Phe Ala Lys Arg 
145                 150                 155                 160 


Gln Gln Glu Ala Met Arg Glu Pro Arg Ser Thr His Ser Arg Trp Arg 
                165                 170                 175     


Lys Arg Thr Arg Ser Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys 
            180                 185                 190         


Arg Ser Gly Ala Pro Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp 
        195                 200                 205             


Tyr Val Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp 
    210                 215                 220                 


Leu Ala Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly 
225                 230                 235                 240 


Arg His Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn 
                245                 250                 255     


Ile Ile Leu Ser Ser Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val 
            260                 265                 270         


Lys Ser Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile 
        275                 280                 285             


Met Val Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala 
    290                 295                 300                 


Gln Lys Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr 
305                 310                 315                 320 


His Phe Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu 
                325                 330                 335     


Phe His Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile 
            340                 345                 350         


Leu Glu Arg Arg 
        355     


<210>  12
<211>  3366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catggtgagc gttcctacga catggtgctc agtagctctt gcgcttctgg tagcgctcca     1980

tgaaggcaaa ggccaagcgg ccgcaaccct cgagcagccg gcttcatcct cccacgccca     2040

aggcacgcac ctcagactca gaaggtgttc ctgttcctca tggctggata aagaatgtgt     2100

ttatttttgc catttggata ttatttgggt caatacgcca gaacaaacgg ccccttacgg     2160

gcttggtaat ccgccacgac ggagaaggag gagtctccct cgcagatgcc aatgctcatc     2220

tgcacgcgac cctgcatgcg ctacgttctg cctcagacga ccgtggactg aagctggtgc     2280

agtgccaagc cgcaaatccc ctgccgatgt gttccaaacg gggaagaccg gggctaccac     2340

tggagaactt ctgcaacgct tgcgggacat ttctacagtc aaatccctgt ttgcaaaaag     2400

gcaacaggag gcgatgcgcg agccccgatc tacccatagc cggtggcgga aaagaaccag     2460

atctcgcaag aagcgcagca ccagatctcg caagaagcgc agcggggccc ccatgatatc     2520

tctgatcgct gctcttgctg tggactacgt gattggtatg gagaatgcta tgccctggaa     2580

tctgcctgca gacctggcat ggtttaagag gaacaccctt aataaacctg taatcatggg     2640

acgacataca tgggagagta tcggcaggcc attgcccggg aggaagaata taattctgag     2700

ttcccagcct tctactgatg atagggtaac ttgggtcaag agcgtcgacg aggccatcgc     2760

cgcttgcggg gatgtgcctg aaatcatggt tatcgggggc ggacgggtga ttgagcaatt     2820

tctgcccaag gcacagaagc tgtatctgac ccatatagac gccgaggtgg agggagatac     2880

acactttccc gactatgagc ccgatgattg ggagagtgtc tttagcgaat ttcatgacgc     2940

cgacgcacag aattcccata gctactgctt cgaaattctc gaacggcgct aggcggccgc     3000

gcggatccag acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag     3060

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata     3120

agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg     3180

gaggtgtggg aggtttttta gtcgactggg gagagatctg aggaacccct agtgatggag     3240

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg     3300

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg     3360

gccaac                                                                3366


<210>  13
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                  40                  45              


Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                  55                  60                  


Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                 120                 125             


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                 135                 140                 


Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                 200                 205             


Thr Arg Ser Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys Arg Ser 
    210                 215                 220                 


Gly Ala Pro Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val 
225                 230                 235                 240 


Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala 
                245                 250                 255     


Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His 
            260                 265                 270         


Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile 
        275                 280                 285             


Leu Ser Ser Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys Ser 
    290                 295                 300                 


Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val 
305                 310                 315                 320 


Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys 
                325                 330                 335     


Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe 
            340                 345                 350         


Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His 
        355                 360                 365             


Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu 
    370                 375                 380                 


Arg Arg 
385     


<210>  14
<211>  3456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catgaaactc ctgccgtctg tagtcctgaa actgtttctg gctgctgtgt tgagtgctct     1980

cgttacggga gagtccttgg agaggcttcg acgcggtttg gcagcaggta cgtcaaaccc     2040

agatccccct accgtgagta cggatcagct tctgccgctc ggcggaggaa gggaccgcaa     2100

ggtgcgcgat ctgcaggagg cggaccttga cctgcttcga gttacattgt cctctaagcc     2160

tcaagctctg gcgacgccga acaaagagga gcatggtaag cgaaagaaga aaggcaaagg     2220

gctgggaaaa aaacgcgacc cctgtcttcg caagtataag gacttctgta ttcatggaga     2280

gtgtaagtat gttaaagagc ttcgagctcc cagttgcatt tgccaccctg ggtatcacgg     2340

ggaacgctgt catggcttgt cattgccagt tgaaaatcgc ttgtatacgt atgaccatac     2400

cactatcctc gcagtagtag ctgttgtcct ttccagcgtt tgtttgctgg tcatcgtcgg     2460

cttgctgatg tttcggtacc accgacgggg aggttacgat gtagagaacg aggagaaagt     2520

caagctgggc atgacaaata gccataccag atctcgcaag aagcgcagca ccagatctcg     2580

caagaagcgc agcggggccc ccatgatatc tctgatcgct gctcttgctg tggactacgt     2640

gattggtatg gagaatgcta tgccctggaa tctgcctgca gacctggcat ggtttaagag     2700

gaacaccctt aataaacctg taatcatggg acgacataca tgggagagta tcggcaggcc     2760

attgcccggg aggaagaata taattctgag ttcccagcct tctactgatg atagggtaac     2820

ttgggtcaag agcgtcgacg aggccatcgc cgcttgcggg gatgtgcctg aaatcatggt     2880

tatcgggggc ggacgggtga ttgagcaatt tctgcccaag gcacagaagc tgtatctgac     2940

ccatatagac gccgaggtgg agggagatac acactttccc gactatgagc ccgatgattg     3000

ggagagtgtc tttagcgaat ttcatgacgc cgacgcacag aattcccata gctactgctt     3060

cgaaattctc gaacggcgct aggcggccgc gcggatccag acatgataag atacattgat     3120

gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt     3180

gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat     3240

tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta gtcgactggg     3300

gagagatctg aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     3360

ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca     3420

gtgagcgagc gagcgcgcag agagggagtg gccaac                               3456


<210>  15
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Met Met Asp Leu Glu Leu Pro Pro Pro Gly Leu Pro Ser Gln Gln Asp 
1               5                   10                  15      


Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
            20                  25                  30          


Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Arg Lys Glu Tyr Glu Leu 
        35                  40                  45              


Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
    50                  55                  60                  


Glu Gln Glu Lys Ala Phe Phe Ala Gln Leu Gln Leu Asp Glu Glu Thr 
65                  70                  75                  80  


Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Ile Gln Ser Glu Thr 
                85                  90                  95      


Ser Gly Ser Ala Asn Tyr Ser Gln Val Ala His Ile Pro Lys Ser Asp 
            100                 105                 110         


Ala Leu Tyr Phe Asp Asp Cys Met Gln Leu Leu Ala Gln Thr Phe Pro 
        115                 120                 125             


Phe Val Asp Asp Asn Glu Val Ser Ser Ala Thr Phe Gln Ser Leu Val 
    130                 135                 140                 


Pro Asp Ile Pro Gly His Ile Glu Ser Pro Val Phe Ile Ala Thr Asn 
145                 150                 155                 160 


Gln Ala Gln Ser Pro Glu Thr Ser Val Ala Gln Val Ala Pro Val Asp 
                165                 170                 175     


Leu Asp Gly Met Gln Gln Asp Ile Glu Gln Val Trp Glu Glu Leu Leu 
            180                 185                 190         


Ser Ile Pro Glu Leu Gln Cys Leu Asn Ile Glu Asn Asp Lys Leu Val 
        195                 200                 205             


Glu Thr Thr Met Val Pro Ser Pro Glu Ala Lys Leu Thr Glu Val Asp 
    210                 215                 220                 


Asn Tyr His Phe Tyr Ser Ser Ile Pro Ser Met Glu Lys Glu Val Gly 
225                 230                 235                 240 


Asn Cys Ser Pro His Phe Leu Asn Ala Phe Glu Asp Ser Phe Ser Ser 
                245                 250                 255     


Ile Leu Ser Thr Glu Asp Pro Asn Gln Leu Thr Val Asn Ser Leu Asn 
            260                 265                 270         


Ser Asp Ala Thr Val Asn Thr Asp Phe Gly Asp Glu Phe Tyr Ser Ala 
        275                 280                 285             


Phe Ile Ala Glu Pro Ser Ile Ser Asn Ser Met Pro Ser Pro Ala Thr 
    290                 295                 300                 


Leu Ser His Ser Leu Ser Glu Leu Leu Asn Gly Pro Ile Asp Val Ser 
305                 310                 315                 320 


Asp Leu Ser Leu Cys Lys Ala Phe Asn Gln Asn His Pro Glu Ser Thr 
                325                 330                 335     


Ala Glu Phe Asn Asp Ser Asp Ser Gly Ile Ser Leu Asn Thr Ser Pro 
            340                 345                 350         


Ser Val Ala Ser Pro Glu His Ser Val Glu Ser Ser Ser Tyr Gly Asp 
        355                 360                 365             


Thr Leu Leu Gly Leu Ser Asp Ser Glu Val Glu Glu Leu Asp Ser Ala 
    370                 375                 380                 


Pro Gly Ser Val Lys Gln Asn Gly Pro Lys Thr Pro Val His Ser Ser 
385                 390                 395                 400 


Gly Asp Met Val Gln Pro Leu Ser Pro Ser Gln Gly Gln Ser Thr His 
                405                 410                 415     


Val His Asp Ala Gln Cys Glu Asn Thr Pro Glu Lys Glu Leu Pro Val 
            420                 425                 430         


Ser Pro Gly His Arg Lys Thr Pro Phe Thr Lys Asp Lys His Ser Ser 
        435                 440                 445             


Arg Leu Glu Ala His Leu Thr Arg Asp Glu Leu Arg Ala Lys Ala Leu 
    450                 455                 460                 


His Ile Pro Phe Pro Val Glu Lys Ile Ile Asn Leu Pro Val Val Asp 
465                 470                 475                 480 


Phe Asn Glu Met Met Ser Lys Glu Gln Phe Asn Glu Ala Gln Leu Ala 
                485                 490                 495     


Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln 
            500                 505                 510         


Asn Cys Arg Lys Arg Lys Leu Glu Asn Ile Val Glu Leu Glu Gln Asp 
        515                 520                 525             


Leu Asp His Leu Lys Asp Glu Lys Glu Lys Leu Leu Lys Glu Lys Gly 
    530                 535                 540                 


Glu Asn Asp Lys Ser Leu His Leu Leu Lys Lys Gln Leu Ser Thr Leu 
545                 550                 555                 560 


Tyr Leu Glu Val Phe Ser Met Leu Arg Asp Glu Asp Gly Lys Pro Tyr 
                565                 570                 575     


Ser Pro Ser Glu Tyr Ser Leu Gln Gln Thr Arg Asp Gly Asn Val Phe 
            580                 585                 590         


Leu Val Pro Lys Ser Lys Lys Pro Asp Val Lys Lys Asn Thr Arg Ser 
        595                 600                 605             


Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys Arg Ser Gly Ala Pro 
    610                 615                 620                 


Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met 
625                 630                 635                 640 


Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys 
                645                 650                 655     


Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu 
            660                 665                 670         


Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser 
        675                 680                 685             


Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu 
    690                 695                 700                 


Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly 
705                 710                 715                 720 


Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu 
                725                 730                 735     


Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr 
            740                 745                 750         


Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp 
        755                 760                 765             


Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
    770                 775                 780             


<210>  16
<211>  4647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catgatggat ctcgaacttc cccctccagg cctgcctagc cagcaagaca tggaccttat     1980

cgacatcctg tggcgccagg atattgatct cggtgtgtct agggaagtct ttgacttttc     2040

ccaaaggagg aaggaatatg agcttgagaa acaaaagaag cttgaaaagg aacggcaaga     2100

gcagcttcaa aaggagcagg aaaaagcatt ctttgcgcaa ttgcagcttg atgaagaaac     2160

cggcgaattc cttccaatac aaccagctca acatatccaa tccgagacct caggttccgc     2220

aaattactcc caagtggcac atataccgaa atccgacgcg ttgtacttcg acgattgtat     2280

gcagctgctc gcacaaacgt tccctttcgt ggacgataac gaagtgagtt ctgctacttt     2340

ccagtcactt gttccagaca tccccggaca tattgaatcc ccagtgttta tagcgacaaa     2400

ccaagcccaa tcacctgaga cgagtgtcgc ccaagtagcc ccagtcgatc tggatggtat     2460

gcaacaggac attgaacaag tctgggaaga gctgcttagc attcctgaac tgcagtgcct     2520

gaacatcgaa aacgacaaat tggtagagac aactatggta ccctcacctg aggccaagtt     2580

gaccgaggtg gacaattatc atttttactc ttcaatacct agtatggaga aagaagtcgg     2640

taattgttcc cctcatttcc tgaacgcgtt cgaagacagc tttagcagca tcttgtccac     2700

agaagaccca aatcaattga cggtaaactc cttgaactca gacgcgacag tgaataccga     2760

ttttggtgat gaattttatt cagcatttat agccgagcca agcatcagta attctatgcc     2820

cagccccgca actctctccc acagtctttc agaattgctc aacggaccca tcgatgtgag     2880

tgatctgtcc ctctgcaaag cgtttaacca aaaccatccg gagagtacgg ccgagttcaa     2940

cgacagtgat agtggtattt cactcaatac ctcaccctcc gtggccagtc cggagcacag     3000

tgttgaatca agctcctacg gggacacatt gctgggcctc tcagacagcg aagtcgaaga     3060

acttgacagc gcccccggat ccgtaaagca aaatgggccg aaaactccgg tgcattcatc     3120

aggtgatatg gtacagccac tttcaccaag tcagggacaa agtacgcacg tccatgacgc     3180

gcaatgtgaa aatactcctg agaaagagct cccggtatca ccggggcacc ggaagacccc     3240

ttttactaag gacaaacata gtagtcgctt ggaggctcat ttgactcgag atgagctccg     3300

cgcaaaagca ctccatattc catttcccgt tgaaaagatt attaacctcc cggtagtgga     3360

cttcaacgag atgatgtcta aggagcagtt taatgaggcg cagcttgcac tgataaggga     3420

catacgacgc agaggtaaga ataaggtggc tgcccaaaac tgcaggaagc gaaagctcga     3480

gaacattgta gaacttgagc aggaccttga tcacctgaaa gatgagaagg aaaaattgct     3540

taaagagaaa ggtgagaatg ataaaagctt gcatcttctc aaaaaacagc tgagcacatt     3600

gtatcttgag gtcttcagca tgctcagaga tgaagatggg aaaccgtatt ctccgagcga     3660

atacagtctg cagcagaccc gggatggcaa tgtgttcctc gtacccaaaa gcaaaaaacc     3720

tgatgttaag aagaatacca gatctcgcaa gaagcgcagc accagatctc gcaagaagcg     3780

cagcggggcc cccatgatat ctctgatcgc tgctcttgct gtggactacg tgattggtat     3840

ggagaatgct atgccctgga atctgcctgc agacctggca tggtttaaga ggaacaccct     3900

taataaacct gtaatcatgg gacgacatac atgggagagt atcggcaggc cattgcccgg     3960

gaggaagaat ataattctga gttcccagcc ttctactgat gatagggtaa cttgggtcaa     4020

gagcgtcgac gaggccatcg ccgcttgcgg ggatgtgcct gaaatcatgg ttatcggggg     4080

cggacgggtg attgagcaat ttctgcccaa ggcacagaag ctgtatctga cccatataga     4140

cgccgaggtg gagggagata cacactttcc cgactatgag cccgatgatt gggagagtgt     4200

ctttagcgaa tttcatgacg ccgacgcaca gaattcccat agctactgct tcgaaattct     4260

cgaacggcgc taggcggccg cgcggatcca gacatgataa gatacattga tgagtttgga     4320

caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt     4380

gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat     4440

tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt agtcgactgg ggagagatct     4500

gaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     4560

gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc agtgagcgag     4620

cgagcgcgca gagagggagt ggccaac                                         4647


<210>  17
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser 
            20                  25                  30          


Lys Glu Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu 
        35                  40                  45              


Met Gln Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly 
    50                  55                  60                  


Leu Asp Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu 
                85                  90                  95      


Gln Thr Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp 
            100                 105                 110         


Leu Glu Gln Arg Leu Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu 
        115                 120                 125             


Asn Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu 
    130                 135                 140                 


Gly Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser 
145                 150                 155                 160 


Asp Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro 
                165                 170                 175     


Thr Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys 
            180                 185                 190         


Arg Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val 
        195                 200                 205             


Phe Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro 
    210                 215                 220                 


His Gln Ala Leu Arg Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys 
225                 230                 235                 240 


Gly Lys Arg Leu Met Thr Arg Gly Gln Leu Pro Arg Thr Arg Ser Arg 
                245                 250                 255     


Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys Arg Ser Gly Ala Pro Met 
            260                 265                 270         


Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu 
        275                 280                 285             


Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg 
    290                 295                 300                 


Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser 
305                 310                 315                 320 


Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln 
                325                 330                 335     


Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala 
            340                 345                 350         


Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly 
        355                 360                 365             


Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr 
    370                 375                 380                 


His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu 
385                 390                 395                 400 


Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala 
                405                 410                 415     


Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
            420                 425                 430 


<210>  18
<211>  3588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catgggggtg cttttgacac agcgcacact cctgagcttg gttctggctc tcctgttccc     1980

gtcaatggct tctatggcgg ccataggctc atgttctaaa gaataccgag tgcttctggg     2040

ccaacttcag aagcagacgg acctcatgca ggatacaagc cgccttttgg acccatatat     2100

aaggatccaa gggttggatg tgccgaagct gagggaacac tgtcgagaac gacctggagc     2160

ttttccaagc gaagaaaccc tcagaggtct tgggaggagg ggctttttgc agacgctcaa     2220

cgcgaccctg gggtgtgtgc tccaccgact tgcagatctc gagcagcgcc tgccaaaagc     2280

acaggatctg gagcggagtg gacttaacat cgaagacctg gaaaaattgc agatggctcg     2340

accgaacatt cttggccttc gaaacaacat ctactgtatg gcacagctgc tggataactc     2400

agatacagcc gaacctacaa aagcagggcg gggcgcgtcc caaccaccta ctcccacacc     2460

agcctccgat gcctttcaga gaaagcttga agggtgtagg tttctccacg gctatcatcg     2520

cttcatgcat tcagtaggga gggtgttctc aaaatgggga gagtcaccta atcgatcaag     2580

gaggcactca ccccatcagg ctcttcggaa gggcgttcgg cgcactcgcc cgagcaggaa     2640

gggtaaaagg ctgatgactc ggggtcaact gccaaggacc agatctcgca agaagcgcag     2700

caccagatct cgcaagaagc gcagcggggc ccccatgata tctctgatcg ctgctcttgc     2760

tgtggactac gtgattggta tggagaatgc tatgccctgg aatctgcctg cagacctggc     2820

atggtttaag aggaacaccc ttaataaacc tgtaatcatg ggacgacata catgggagag     2880

tatcggcagg ccattgcccg ggaggaagaa tataattctg agttcccagc cttctactga     2940

tgatagggta acttgggtca agagcgtcga cgaggccatc gccgcttgcg gggatgtgcc     3000

tgaaatcatg gttatcgggg gcggacgggt gattgagcaa tttctgccca aggcacagaa     3060

gctgtatctg acccatatag acgccgaggt ggagggagat acacactttc ccgactatga     3120

gcccgatgat tgggagagtg tctttagcga atttcatgac gccgacgcac agaattccca     3180

tagctactgc ttcgaaattc tcgaacggcg ctaggcggcc gcgcggatcc agacatgata     3240

agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt     3300

tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt     3360

aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt     3420

tagtcgactg gggagagatc tgaggaaccc ctagtgatgg agttggccac tccctctctg     3480

cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt     3540

cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaac                  3588


<210>  19
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser 
            20                  25                  30          


Lys Glu Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu 
        35                  40                  45              


Met Gln Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly 
    50                  55                  60                  


Leu Asp Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu 
                85                  90                  95      


Gln Thr Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp 
            100                 105                 110         


Leu Glu Gln Arg Leu Gly Gly Gly Asn Ile Glu Asp Leu Glu Lys Leu 
        115                 120                 125             


Gln Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn Ile Tyr Cys 
    130                 135                 140                 


Met Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro Thr Lys Ala 
145                 150                 155                 160 


Gly Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala Ser Asp Ala 
                165                 170                 175     


Phe Gln Arg Lys Leu Glu Gly Cys Arg Phe Leu His Gly Tyr His Arg 
            180                 185                 190         


Phe Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly Glu Ser Pro 
        195                 200                 205             


Asn Arg Ser Arg Arg His Ser Pro His Gln Ala Leu Arg Lys Gly Val 
    210                 215                 220                 


Arg Arg Thr Arg Pro Ser Arg Lys Gly Lys Arg Leu Met Thr Arg Ser 
225                 230                 235                 240 


Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys Arg Ser Gly Ala Pro 
                245                 250                 255     


Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met 
            260                 265                 270         


Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys 
        275                 280                 285             


Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu 
    290                 295                 300                 


Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser 
305                 310                 315                 320 


Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu 
                325                 330                 335     


Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly 
            340                 345                 350         


Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu 
        355                 360                 365             


Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr 
    370                 375                 380                 


Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp 
385                 390                 395                 400 


Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
                405                 410                 415 


<210>  20
<211>  3543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catgggtgtg ttgctcactc aaaggacctt gttgtccctg gtcctggcac tcttgttccc     1980

atctatggcg agtatggcgg ctattggctc atgctctaaa gagtacagag ttctgctcgg     2040

tcaactgcaa aagcaaacgg acctgatgca agatacgtcc aggttgctcg acccttatat     2100

taggatccag ggactcgacg ttccgaagct tagagagcac tgtcgcgagc gaccaggtgc     2160

ctttcccagt gaagaaacac tgaggggttt gggcaggcgc ggtttcttgc agacccttaa     2220

tgctacattg gggtgcgtat tgcatcgcct ggcagatctc gagcaaagac tcggaggtgg     2280

caatatcgag gatcttgaaa agctccagat ggctcgcccg aacatactcg ggctgaggaa     2340

taatatatat tgtatggctc aactcctcga caactcagac actgcggagc ctacgaaagc     2400

aggaaggggc gcatcacaac cacctacacc tactcctgcc agtgatgcct ttcagcgcaa     2460

gcttgagggc tgccgatttc tccacggcta tcatcggttc atgcactccg ttggccgagt     2520

gttttcaaaa tggggggaat ctcctaaccg atctagaagg cactcacctc accaggcact     2580

gcggaaaggc gttaggagaa cccggccaag ccgcaaagga aagcgcctga tgaccagatc     2640

tcgcaagaag cgcagcacca gatctcgcaa gaagcgcagc ggggccccca tgatatctct     2700

gatcgctgct cttgctgtgg actacgtgat tggtatggag aatgctatgc cctggaatct     2760

gcctgcagac ctggcatggt ttaagaggaa cacccttaat aaacctgtaa tcatgggacg     2820

acatacatgg gagagtatcg gcaggccatt gcccgggagg aagaatataa ttctgagttc     2880

ccagccttct actgatgata gggtaacttg ggtcaagagc gtcgacgagg ccatcgccgc     2940

ttgcggggat gtgcctgaaa tcatggttat cgggggcgga cgggtgattg agcaatttct     3000

gcccaaggca cagaagctgt atctgaccca tatagacgcc gaggtggagg gagatacaca     3060

ctttcccgac tatgagcccg atgattggga gagtgtcttt agcgaatttc atgacgccga     3120

cgcacagaat tcccatagct actgcttcga aattctcgaa cggcgctagg cggccgcgcg     3180

gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga     3240

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     3300

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag     3360

gtgtgggagg ttttttagtc gactggggag agatctgagg aacccctagt gatggagttg     3420

gccactccct ctctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt     3480

cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc     3540

aac                                                                   3543


<210>  21
<211>  948
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met Thr Arg Ser Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys 
    770                 775                 780                 


Arg Ser Gly Ala Pro Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp 
785                 790                 795                 800 


Tyr Val Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp 
                805                 810                 815     


Leu Ala Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly 
            820                 825                 830         


Arg His Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn 
        835                 840                 845             


Ile Ile Leu Ser Ser Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val 
    850                 855                 860                 


Lys Ser Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile 
865                 870                 875                 880 


Met Val Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala 
                885                 890                 895     


Gln Lys Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr 
            900                 905                 910         


His Phe Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu 
        915                 920                 925             


Phe His Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile 
    930                 935                 940                 


Leu Glu Arg Arg 
945             


<210>  22
<211>  5142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catggctcaa tggaaccaat tgcaacaact tgatactcga tacctggagc aactccatca     1980

gctgtactca gattcatttc cgatggagct ccggcagttt ctggctccat ggatagaatc     2040

acaggattgg gcctacgcgg cttcaaagga aagtcacgcg accctcgtat ttcacaacct     2100

cctgggggaa attgatcagc aatatagtcg gtttctgcaa gaaagcaacg tcttgtacca     2160

acataacttg aggaggatta agcaatttct ccaaagccgg tacttggaga agcctatgga     2220

aatcgctcgc attgtagcga ggtgcctgtg ggaggagagt cgccttctgc agaccgccgc     2280

cacagccgct caacaaggtg ggcaggctaa tcatcccacc gctgctgtgg tcaccgaaaa     2340

gcagcagatg ctcgagcaac accttcagga cgtcagaaag agggttcagg atctggaaca     2400

aaagatgaaa gtcgtggaga atttgcagga tgattttgat tttaactaca agaccttgaa     2460

atcccaaggc gatatgcaag atcttaatgg aaacaaccag tcagtgacca ggcagaagat     2520

gcaacaactt gaacaaatgt tgactgccct cgatcaaatg agacgcagta tagtaagcga     2580

gttggccggt cttctctcag cgatggagta cgtacagaaa acgctgactg atgaagagct     2640

ggctgactgg aagcggcggc agcagatagc ttgcatcggt gggcccccaa atatatgcct     2700

ggatcgcctg gagaactgga taacgagtct ggccgagagt cagctgcaga ctcgccagca     2760

gatcaaaaaa ctggaagaac tccagcaaaa agtttcatac aagggagatc cgattgtaca     2820

gcatcgcccc atgctggaag agcgaattgt tgaactcttt agaaatttga tgaagagcgc     2880

gttcgttgta gagcggcagc cgtgtatgcc tatgcacccg gaccggccac ttgtgataaa     2940

gaccggagtt cagtttacaa caaaggtccg actgcttgtc aaatttccgg aattgaacta     3000

tcaattgaag atcaaggttt gcatcgataa ggattctggc gatgttgcgg cgttgcgcgg     3060

cagccgcaag tttaacatac ttggcactaa taccaaggtt atgaacatgg aggagtccaa     3120

caacggctca ctcagtgctg aattcaagca ccttacgctg agagaacaga gatgcggtaa     3180

cgggggacgc gccaactgtg atgcctcact tattgtcact gaagagcttc acctgataac     3240

gttcgaaact gaggtttacc atcaaggcct gaaaatagat ctggagactc attctctgcc     3300

cgttgtcgtt atttctaaca tttgccagat gcccaatgca tgggcgagca ttctgtggta     3360

taatatgctg acaaacaatc cgaagaacgt caacttcttc acgaagccgc cgatcggtac     3420

ctgggatcag gtggcggaag tccttagctg gcagttcagc tccaccacca agaggggttt     3480

gtcaatagag caattgacta cgttggctga gaagctcctg ggacctggag taaattacag     3540

tgggtgtcag atcacatggg ctaaattttg caaggaaaac atggcaggta agggtttttc     3600

cttttgggtc tggcttgata acataataga tctcgtcaaa aagtacatac tcgcgctgtg     3660

gaacgagggt tacataatgg gttttatatc taaagaaagg gagagagcga ttttgtccac     3720

taaaccaccg ggcacgtttc ttctccgatt ttccgagtca agcaaagaag gtggcgtaac     3780

atttacctgg gtcgaaaagg acattagtgg aaagacgcaa attcaaagtg tggaacctta     3840

tacgaaacag caactgaata acatgtcctt tgcggagata ataatggggt acaaaattat     3900

ggatgctact aatatactcg ttagccctct ggtctacctt tacccagaca tccccaagga     3960

ggaggcgttc ggaaagtatt gccgaccgga atcccaagag catcccgaag cggaccccgg     4020

tagtgccgca ccctacctta aaactaagtt catttgcgtc accccaacga cgtgcagcaa     4080

cacaatagac ttgccgatga gtccccgaac gctcgatagt ctcatgcagt tcggaaacaa     4140

tggcgaggga gctgagccct ccgccggcgg acaatttgag agcctcacct ttgacatgga     4200

gcttacatca gagtgcgcga caagcccgat gaccagatct cgcaagaagc gcagcaccag     4260

atctcgcaag aagcgcagcg gggcccccat gatatctctg atcgctgctc ttgctgtgga     4320

ctacgtgatt ggtatggaga atgctatgcc ctggaatctg cctgcagacc tggcatggtt     4380

taagaggaac acccttaata aacctgtaat catgggacga catacatggg agagtatcgg     4440

caggccattg cccgggagga agaatataat tctgagttcc cagccttcta ctgatgatag     4500

ggtaacttgg gtcaagagcg tcgacgaggc catcgccgct tgcggggatg tgcctgaaat     4560

catggttatc gggggcggac gggtgattga gcaatttctg cccaaggcac agaagctgta     4620

tctgacccat atagacgccg aggtggaggg agatacacac tttcccgact atgagcccga     4680

tgattgggag agtgtcttta gcgaatttca tgacgccgac gcacagaatt cccatagcta     4740

ctgcttcgaa attctcgaac ggcgctaggc ggccgcgcgg atccagacat gataagatac     4800

attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa     4860

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac     4920

aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttagtcg     4980

actggggaga gatctgagga acccctagtg atggagttgg ccactccctc tctgcgcgct     5040

cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg     5100

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca ac                        5142


<210>  23
<211>  948
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Phe Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met Thr Arg Ser Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys 
    770                 775                 780                 


Arg Ser Gly Ala Pro Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp 
785                 790                 795                 800 


Tyr Val Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp 
                805                 810                 815     


Leu Ala Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly 
            820                 825                 830         


Arg His Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn 
        835                 840                 845             


Ile Ile Leu Ser Ser Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val 
    850                 855                 860                 


Lys Ser Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile 
865                 870                 875                 880 


Met Val Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala 
                885                 890                 895     


Gln Lys Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr 
            900                 905                 910         


His Phe Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu 
        915                 920                 925             


Phe His Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile 
    930                 935                 940                 


Leu Glu Arg Arg 
945             


<210>  24
<211>  5142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  24
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catggcccag tggaatcaac ttcaacaact tgatacccgc tacctggaac aacttcatca     1980

actctacagt gatagctttc ctatggagct cagacagttc ctcgcgccgt ggattgaaag     2040

ccaggactgg gcgtatgctg cttcaaagga gagtcatgca actctcgtat tccataatct     2100

gctcggagag atcgatcaac aatacagcag gtttctgcag gaatctaacg tgctttatca     2160

acacaatctg aggcggatta aacaattcct gcaatctcga tatcttgaaa aacccatgga     2220

gattgcccgg atcgtcgcac gctgtctgtg ggaagagagt cgactgttgc agacggcagc     2280

tactgctgcc cagcagggcg gacaggcgaa tcatccgact gccgctgtag tgacggaaaa     2340

acaacaaatg ctggagcaac atctgcaaga cgtcagaaaa cgagtacagg acctcgaaca     2400

gaagatgaaa gtggtcgaaa acttgcaaga cgacttcgat tttaattata aaacgctgaa     2460

atcccagggg gatatgcaag accttaacgg caataatcag tctgttacca gacagaaaat     2520

gcagcagctc gagcaaatgc tgacggctct tgaccagatg agaagaagca tagtctcaga     2580

attggcaggc ctcctctctg ccatggagta cgtacagaag acgttgacag atgaggaact     2640

cgctgattgg aagagacgcc aacagattgc ttgcataggg ggtccaccta atatatgcct     2700

cgaccggttg gaaaactgga taacatcttt ggctgaatct cagctccaaa cacgccagca     2760

aataaaaaag cttgaggagt tgcagcagaa ggttagttac aagggagatc ccattgtgca     2820

gcataggcca atgctggaag agaggattgt tgagctgttt aggaatctga tgaaaagtgc     2880

cttcgtagtg gagagacagc catgcatgcc aatgcatcct gacagaccac tggttataaa     2940

gactggagtt caatttacaa caaaagttag actcctggtc aagttcccgg agctcaacta     3000

tcaactgaag ataaaagtct gtattgacaa ggatagtggc gatgttgcag ccttgagggg     3060

tagccgaaaa tttaacattc tcggaacgaa cacaaaagtg atgaacatgg aggaatcaaa     3120

taatggttct ctctccgcag agtttaagca ccttactctg cgcgaacaac gctgcggaaa     3180

cggcggccgg gccaattgcg atgccagcct tatagtgacg gaagagctgc atctgataac     3240

tttcgagacg gaagtctatc atcaaggcct caaaattgac ttggagactc actccttgcc     3300

cgtagtggtt atttcaaata tatgccaaat gcctaatgca tgggcatcaa tcctttggta     3360

caatatgctt actaataacc caaagaacgt taatttcttc actaaacctc caattggtac     3420

ttgggaccaa gttgccgagg tattgagttg gcagttttcc tcaacaacta agagagggtt     3480

gagcatagaa cagctgacca cactggcgga gaaacttctg ggacccggcg tcaactattc     3540

tggatgtcag attacctggg ccaaattctg caaagaaaat atggctggca agggtttcag     3600

cttctgggta tggcttgaca atataattga cctcgtaaaa aagtacatcc tcgctctttg     3660

gaatgaaggt tatattatgg gctttataag taaagagcga gagcgggcta tcttgtcaac     3720

gaagcccccg ggtacgttcc tgttgcgatt ctcagagagc tctaaggagg gtggcgtgac     3780

tttcacgtgg gtagagaaag acatctctgg taagactcaa atccaatcag ttgaaccgta     3840

cacaaagcaa caactgaata acatgtcctt cgcagaaatt atcatggggt acaagattat     3900

ggacgcgacc aacatcctgg tcagtccgct cgtttatctc tatcccgata tacctaaaga     3960

agaagcattt ggaaagtact gccggccaga atcacaagag catcctgagg ctgatcctgg     4020

ttccgctgca ccgttcttga aaacgaaatt catatgtgtc actcctacaa cctgttcaaa     4080

cacgatagac cttccaatgt ctcctaggac gttggacagc cttatgcagt ttggtaataa     4140

tggggagggg gccgagccgt ccgcgggggg tcagtttgag agccttacat tcgatatgga     4200

gctgacctct gagtgtgcaa cttctccgat gaccagatct cgcaagaagc gcagcaccag     4260

atctcgcaag aagcgcagcg gggcccccat gatatctctg atcgctgctc ttgctgtgga     4320

ctacgtgatt ggtatggaga atgctatgcc ctggaatctg cctgcagacc tggcatggtt     4380

taagaggaac acccttaata aacctgtaat catgggacga catacatggg agagtatcgg     4440

caggccattg cccgggagga agaatataat tctgagttcc cagccttcta ctgatgatag     4500

ggtaacttgg gtcaagagcg tcgacgaggc catcgccgct tgcggggatg tgcctgaaat     4560

catggttatc gggggcggac gggtgattga gcaatttctg cccaaggcac agaagctgta     4620

tctgacccat atagacgccg aggtggaggg agatacacac tttcccgact atgagcccga     4680

tgattgggag agtgtcttta gcgaatttca tgacgccgac gcacagaatt cccatagcta     4740

ctgcttcgaa attctcgaac ggcgctaggc ggccgcgcgg atccagacat gataagatac     4800

attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa     4860

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac     4920

aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttagtcg     4980

actggggaga gatctgagga acccctagtg atggagttgg ccactccctc tctgcgcgct     5040

cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg     5100

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca ac                        5142


<210>  25
<211>  948
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Glu Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met Thr Arg Ser Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys 
    770                 775                 780                 


Arg Ser Gly Ala Pro Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp 
785                 790                 795                 800 


Tyr Val Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp 
                805                 810                 815     


Leu Ala Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly 
            820                 825                 830         


Arg His Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn 
        835                 840                 845             


Ile Ile Leu Ser Ser Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val 
    850                 855                 860                 


Lys Ser Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile 
865                 870                 875                 880 


Met Val Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala 
                885                 890                 895     


Gln Lys Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr 
            900                 905                 910         


His Phe Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu 
        915                 920                 925             


Phe His Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile 
    930                 935                 940                 


Leu Glu Arg Arg 
945             


<210>  26
<211>  5142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  26
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catggctcaa tggaaccagc tccaacagct cgacaccagg tacctggagc aattgcatca     1980

actctatagt gatagcttcc ccatggaact gagacaattc cttgcaccat ggatagagtc     2040

acaggattgg gcgtacgctg caagcaaaga atctcatgca accctcgtat ttcataatct     2100

cctcggtgag atcgaccagc aatactcacg gttccttcag gagtctaatg tgctttatca     2160

acacaacctt cgccggatta agcagttctt gcagagccga tatctcgaga agcctatgga     2220

aatagctagg atcgttgcaa ggtgcttgtg ggaagaaagt agacttctcc aaactgcagc     2280

aacggctgcg cagcagggtg gccaggccaa ccacccgaca gccgccgtgg taacggaaaa     2340

acagcagatg cttgaacaac accttcagga cgtccgcaaa agagtacagg acctggaaca     2400

aaaaatgaag gtcgtcgaaa accttcagga tgacttcgat tttaactata aaaccctcaa     2460

atctcaggga gatatgcaag acctcaacgg taataatcag agcgtcactc gacagaagat     2520

gcagcaactt gagcaaatgc ttacggcact ggatcagatg cgaaggtcca ttgtctccga     2580

acttgccggg ctcctgtcag ccatggagta tgtacagaaa actttgaccg acgaggagtt     2640

ggcagactgg aagaggaggc aacagatagc ctgcattggc gggcccccta acatttgcct     2700

tgacaggttg gaaaactgga ttacatctct ggcggagagt caactgcaga cacggcagca     2760

aataaaaaaa ctggaagagc tccagcagaa ggtgagttac aagggggacc caattgtgca     2820

gcatcgccca atgctggaag aacggattgt tgaattgttt aggaacctca tgaaatccgc     2880

gtttgtcgta gagagacagc cctgtatgcc gatgcatcct gatcgacccc tcgtgatcaa     2940

aactggtgta caattcacaa caaaagtgag gttgctggtc aagttccctg aactcaacta     3000

ccaactgaag attaaagtgt gcattgacaa ggattctgga gacgtggcgg cacttcgcgg     3060

ttcaagaaag tttaacatac tcggcactaa tacaaaagtt atgaatatgg aggagtccaa     3120

caacgggtca ctgtccgccg aatttaagca cttgacgctt cgcgagcaac gatgtggcaa     3180

tgggggcaga gcaaattgcg acgcttcttt gattgtcact gaggaacttc acctgattac     3240

cttcgaaacc gaggtatacc accaagggct gaaaattgac ttggaaaccc atagtctccc     3300

cgtggtggtc attagtaaca tttgccagat gcctaatgct tgggcaagca tcctttggta     3360

caacatgctt acaaacaatc cgaagaacgt caacttcttt accaagccgc ccattggaac     3420

atgggatcaa gtggcggaag tcctcagttg gcagttttcc agtaccacga agcgaggact     3480

ttctatcgag caactgacga cgctggcgga aaaactcttg ggacctggag ttaattactc     3540

cgggtgtcag ataacatggg ccaaattctg caaggagaac atggcgggga aaggtttcag     3600

cttttgggtt tggttggata acataattga tctcgtaaag aaatacatac tggccctctg     3660

gaatgaaggt tatatcatgg gcttcattag taaagaacgg gagagggcca tacttagcac     3720

taagcctcca ggaacgtttc ttctcagatt ttctgagtct tcaaaggagg gaggcgtgac     3780

cttcacctgg gttgaaaaag atatctcagg aaagacacag attcagtccg tcgaaccata     3840

tacgaaacag caactcaata acatgagttt cgcagaaata atcatgggat ataagattat     3900

ggacgcaact aatatactgg tgagtccact cgtttatctc taccccgata tcccgaagga     3960

ggaagcattc ggaaaatact gcagacctga atcccaggaa catccagagg ccgacccagg     4020

ctctgccgct ccatatttga aaactaaatt tatctgcgta acacctacaa cttgcagcaa     4080

tacgatcgat ttgcccatgg aaccacgcac cctcgatagc cttatgcaat tcgggaataa     4140

tggggaagga gcagaaccct ctgcaggagg acaatttgag agcctcacat tcgatatgga     4200

gttgacgtca gaatgcgcaa ccagtccaat gaccagatct cgcaagaagc gcagcaccag     4260

atctcgcaag aagcgcagcg gggcccccat gatatctctg atcgctgctc ttgctgtgga     4320

ctacgtgatt ggtatggaga atgctatgcc ctggaatctg cctgcagacc tggcatggtt     4380

taagaggaac acccttaata aacctgtaat catgggacga catacatggg agagtatcgg     4440

caggccattg cccgggagga agaatataat tctgagttcc cagccttcta ctgatgatag     4500

ggtaacttgg gtcaagagcg tcgacgaggc catcgccgct tgcggggatg tgcctgaaat     4560

catggttatc gggggcggac gggtgattga gcaatttctg cccaaggcac agaagctgta     4620

tctgacccat atagacgccg aggtggaggg agatacacac tttcccgact atgagcccga     4680

tgattgggag agtgtcttta gcgaatttca tgacgccgac gcacagaatt cccatagcta     4740

ctgcttcgaa attctcgaac ggcgctaggc ggccgcgcgg atccagacat gataagatac     4800

attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa     4860

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac     4920

aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttagtcg     4980

actggggaga gatctgagga acccctagtg atggagttgg ccactccctc tctgcgcgct     5040

cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg     5100

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca ac                        5142


<210>  27
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Thr Arg Ser Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys Arg Ser 
                325                 330                 335     


Gly Ala Pro Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val 
            340                 345                 350         


Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala 
        355                 360                 365             


Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His 
    370                 375                 380                 


Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile 
385                 390                 395                 400 


Leu Ser Ser Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys Ser 
                405                 410                 415     


Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val 
            420                 425                 430         


Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys 
        435                 440                 445             


Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe 
    450                 455                 460                 


Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu 
                485                 490                 495     


Arg Arg 
        


<210>  28
<211>  3792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  28
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catgcaatca aaggtgttgc tggcggtggc cctttggttg tgtgtcgaga cccgagcggc     1980

ctccgtgggt cttccctccg tttctctcga tctccctcgg ttgagcatcc aaaaagacat     2040

ccttaccata aaagcaaaca ctaccttgca gatcacatgc agaggtcaga gagatctcga     2100

ttggttgtgg cccaataatc agagcgggtc cgaacagcgg gttgaggtga ccgagtgctc     2160

agatggactt ttctgtaaga ccctcacgat acccaaagtt ataggcaacg atactggtgc     2220

ctacaagtgc ttctaccgag aaacggattt ggcctcagtt atatacgttt atgtgcaaga     2280

ttaccgctcc ccattcatag cgtcagtcag cgaccaacac ggcgttgtct acattacgga     2340

aaacaagaat aagacggtcg tgataccgtg tctcggaagc atctcaaatc tgaatgtctc     2400

cctgtgcgct cgctaccctg agaaaaggtt tgttcctgac ggtaacagaa tatcctggga     2460

tagtaaaaaa ggttttacga ttccctccta tatgattagt tatgctggca tggtgttttg     2520

cgaggctaaa atcaacgatg agtcctacca gtcaataatg tatattgtgg tggttgtggg     2580

ctacaggatc tacgatgtgg ttttgtctcc cagccatgga atcgagttgt ctgtagggga     2640

aaaactggtg cttaactgca cagcgagaac cgaactcaac gttggaatag acttcaactg     2700

ggagtacccg agttccaaac accaacacaa aaaactcgta aacagggatc tgaagaccca     2760

gtcagggtct gagatgaaaa aatttctttc tactctgaca atagatggag tcacccgctc     2820

cgatcaaggg ctctacactt gtgcggcttc ttcagggctg atgaccaaaa aaaattcaac     2880

taccagatct cgcaagaagc gcagcaccag atctcgcaag aagcgcagcg gggcccccat     2940

gatatctctg atcgctgctc ttgctgtgga ctacgtgatt ggtatggaga atgctatgcc     3000

ctggaatctg cctgcagacc tggcatggtt taagaggaac acccttaata aacctgtaat     3060

catgggacga catacatggg agagtatcgg caggccattg cccgggagga agaatataat     3120

tctgagttcc cagccttcta ctgatgatag ggtaacttgg gtcaagagcg tcgacgaggc     3180

catcgccgct tgcggggatg tgcctgaaat catggttatc gggggcggac gggtgattga     3240

gcaatttctg cccaaggcac agaagctgta tctgacccat atagacgccg aggtggaggg     3300

agatacacac tttcccgact atgagcccga tgattgggag agtgtcttta gcgaatttca     3360

tgacgccgac gcacagaatt cccatagcta ctgcttcgaa attctcgaac ggcgctaggc     3420

ggccgcgcgg atccagacat gataagatac attgatgagt ttggacaaac cacaactaga     3480

atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc     3540

attataagct gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt     3600

cagggggagg tgtgggaggt tttttagtcg actggggaga gatctgagga acccctagtg     3660

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag     3720

cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag     3780

ggagtggcca ac                                                         3792


<210>  29
<211>  931
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Thr Arg Ser Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys Arg 
        755                 760                 765             


Ser Gly Ala Pro Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr 
    770                 775                 780                 


Val Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu 
785                 790                 795                 800 


Ala Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg 
                805                 810                 815     


His Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile 
            820                 825                 830         


Ile Leu Ser Ser Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys 
        835                 840                 845             


Ser Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met 
    850                 855                 860                 


Val Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln 
865                 870                 875                 880 


Lys Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His 
                885                 890                 895     


Phe Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe 
            900                 905                 910         


His Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu 
        915                 920                 925             


Glu Arg Arg 
    930     


<210>  30
<211>  5091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  30
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catgcagtca aaggtccttc tcgcggtagc tctgtggttg tgcgtagaga cacgggccgc     1980

ttcagtgggg ctgccttcag taagcctcga tttgccccgg ctttcaatac agaaagatat     2040

tctcacaatc aaggctaata ccactctgca aattacctgt cgcggccaaa gggatctgga     2100

ttggctctgg ccgaataatc aatcagggag tgaacagcgg gtcgaagtga ccgagtgttc     2160

tgacggactt ttttgcaaaa cacttactat cccaaaagta atcgggaacg ataccggggc     2220

ttacaagtgt ttctacagag agacagatct tgctagtgtg atttacgtat atgtgcaaga     2280

ttaccgcagc cctttcatag catccgtatc agaccaacat ggagttgtat acattacaga     2340

gaacaagaac aaaactgtag ttattccctg tttggggtct ataagcaacc tcaacgtaag     2400

cctctgcgct agatacccag agaaacgatt cgtcccggat gggaatagaa tttcctggga     2460

tagcaagaag ggcttcacta ttccgagcta catgatatca tacgcaggta tggtgttctg     2520

cgaagcgaag ataaacgatg agagttatca gtcaatcatg tacatagtgg tggtcgttgg     2580

gtacagaatt tatgatgttg tcctcagtcc gtcccatggc attgaactga gtgtcgggga     2640

aaaattggtg ctgaattgta ccgctaggac agaattgaac gttggcattg actttaactg     2700

ggagtatccg agctcaaagc accagcataa aaagttggtt aacagagatc tgaaaaccca     2760

gtctggcagt gaaatgaaaa agttcctctc tacgctgaca atagacggtg ttacgaggtc     2820

tgatcagggt ttgtacacat gtgctgcatc ttccggtttg atgacaaaga aaaactccac     2880

gtttgttcgc gtgcatgaga agccgtttgt ggcgttcggc tcaggaatgg agtccctcgt     2940

tgaagcgacg gtaggcgagc gggtccggat ccccgctaaa tacttgggct acccaccacc     3000

ggagataaaa tggtataaga atggtatacc gcttgagagt aatcatacga taaaagcggg     3060

tcatgtactc accataatgg aagtaagcga gagagatact ggaaattaca ccgttatcct     3120

gacaaatcca atatccaaag agaagcagtc acacgttgta tcactcgtgg tttatgtccc     3180

ccctcaaata ggagaaaagt cactcatcag tccggtggat agttatcaat acgggacgac     3240

ccagactctc acatgcacag tatatgccat ccctccaccc caccatattc attggtattg     3300

gcagcttgaa gaggaatgcg ccaatgagcc ttcacaggca gtgtcagtta caaatcctta     3360

cccttgtgag gaatggagga gcgtcgagga cttccagggg ggtaataaga tagaagtcaa     3420

taagaatcaa tttgcactca tagaaggaaa gaacaagacg gtttctactt tggtgataca     3480

agccgcaaat gtgtccgcac tctataagtg cgaggcagtc aacaaagttg gtcgcggcga     3540

gcgggtgata agcttccacg tcacgagggg accggaaatc actcttcaac ccgatatgca     3600

acccacggaa caggaatctg tttcactttg gtgtacggcg gataggagta cgtttgagaa     3660

cctcacatgg tataaattgg gaccgcagcc cttgcctatc cacgtggggg agcttcccac     3720

tcctgtttgc aagaatctgg atacactctg gaaactgaat gctactatgt tcagcaattc     3780

taccaatgac atactcatta tggaattgaa aaatgcgtca ctccaagatc agggagatta     3840

cgtatgcctc gctcaggacc gcaagactaa aaagaggcac tgtgttgtcc ggcagcttac     3900

agttcttgaa cgcgtggcgc ctaccattac cggcaatctg gagaatcaaa ctacgtcaat     3960

cggggagagc atcgaggtct catgcacggc cagcggcaat cctccgcccc agattatgtg     4020

gtttaaagac aatgagacgc tggtggagga tagtgggatt gtacttaagg atgggaatcg     4080

caacctcacc attcgaagag tgcgcaagga ggacgaaggg ttgtacacct gccaagcatg     4140

ctccgttctg ggatgcgcaa aagttgaagc attctttata accagatctc gcaagaagcg     4200

cagcaccaga tctcgcaaga agcgcagcgg ggcccccatg atatctctga tcgctgctct     4260

tgctgtggac tacgtgattg gtatggagaa tgctatgccc tggaatctgc ctgcagacct     4320

ggcatggttt aagaggaaca cccttaataa acctgtaatc atgggacgac atacatggga     4380

gagtatcggc aggccattgc ccgggaggaa gaatataatt ctgagttccc agccttctac     4440

tgatgatagg gtaacttggg tcaagagcgt cgacgaggcc atcgccgctt gcggggatgt     4500

gcctgaaatc atggttatcg ggggcggacg ggtgattgag caatttctgc ccaaggcaca     4560

gaagctgtat ctgacccata tagacgccga ggtggaggga gatacacact ttcccgacta     4620

tgagcccgat gattgggaga gtgtctttag cgaatttcat gacgccgacg cacagaattc     4680

ccatagctac tgcttcgaaa ttctcgaacg gcgctaggcg gccgcgcgga tccagacatg     4740

ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt     4800

atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa     4860

gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt gtgggaggtt     4920

ttttagtcga ctggggagag atctgaggaa cccctagtga tggagttggc cactccctct     4980

ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt     5040

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa c              5091


<210>  31
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 
1               5                   10                  15      


Trp Lys His Gly Ala Gly Asp Tyr Arg Ser Pro Phe Ile Ala Ser Val 
            20                  25                  30          


Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys Thr 
        35                  40                  45              


Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser Leu 
    50                  55                  60                  


Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg Ile 
65                  70                  75                  80  


Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile Ser 
                85                  90                  95      


Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser Tyr 
            100                 105                 110         


Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr Asp 
        115                 120                 125             


Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu Lys 
    130                 135                 140                 


Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile Asp 
145                 150                 155                 160 


Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu Val 
                165                 170                 175     


Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe Leu 
            180                 185                 190         


Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr 
        195                 200                 205             


Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr Phe 
    210                 215                 220                 


Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met Thr 
225                 230                 235                 240 


Arg Ser Arg Lys Lys Arg Ser Thr Arg Ser Arg Lys Lys Arg Ser Gly 
                245                 250                 255     


Ala Pro Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile 
            260                 265                 270         


Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp 
        275                 280                 285             


Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr 
    290                 295                 300                 


Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu 
305                 310                 315                 320 


Ser Ser Gln Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val 
                325                 330                 335     


Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile 
            340                 345                 350         


Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu 
        355                 360                 365             


Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro 
    370                 375                 380                 


Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp 
385                 390                 395                 400 


Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg 
                405                 410                 415     


Arg 
    


<210>  32
<211>  3549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  32
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcaacgcgt ctcgaggcgg ccgccgccac     1920

catgaaagtc cttgccgccg gagttgtccc tctcttgctt gtactccact ggaagcacgg     1980

tgcaggagat tatcgctcac catttatagc gagcgtgtca gatcaacatg gcgtggtcta     2040

tataactgag aataagaata aaacggtcgt tatcccctgt ttgggtagca tatctaacct     2100

caacgttagt ttgtgcgctc gataccctga aaagcggttc gtacccgatg gcaatcggat     2160

cagttgggac agtaaaaaag gcttcactat tccgtcatac atgatcagct atgcagggat     2220

ggttttctgc gaagctaaaa tcaatgacga gagttatcag agcattatgt acatcgtagt     2280

tgtcgttggg tatcgaattt acgacgttgt gctgtcccct tctcacggaa ttgaactctc     2340

cgttggagaa aaactcgtat tgaactgtac ggcacgcacg gaattgaatg tagggataga     2400

tttcaactgg gagtatccat catctaaaca tcaacataaa aaacttgtaa atcgagacct     2460

gaagacacag agtgggtccg aaatgaaaaa atttcttagt actctgacta tcgacggggt     2520

aacaagatct gatcaagggc tgtacacctg tgcggccagc tcaggtctta tgacaaaaaa     2580

aaactccact tttgtcagag tgcatgaaaa gccgttcgtg gcatttggtt caggtatgac     2640

cagatctcgc aagaagcgca gcaccagatc tcgcaagaag cgcagcgggg cccccatgat     2700

atctctgatc gctgctcttg ctgtggacta cgtgattggt atggagaatg ctatgccctg     2760

gaatctgcct gcagacctgg catggtttaa gaggaacacc cttaataaac ctgtaatcat     2820

gggacgacat acatgggaga gtatcggcag gccattgccc gggaggaaga atataattct     2880

gagttcccag ccttctactg atgatagggt aacttgggtc aagagcgtcg acgaggccat     2940

cgccgcttgc ggggatgtgc ctgaaatcat ggttatcggg ggcggacggg tgattgagca     3000

atttctgccc aaggcacaga agctgtatct gacccatata gacgccgagg tggagggaga     3060

tacacacttt cccgactatg agcccgatga ttgggagagt gtctttagcg aatttcatga     3120

cgccgacgca cagaattccc atagctactg cttcgaaatt ctcgaacggc gctaggcggc     3180

cgcgcggatc cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg     3240

cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt     3300

ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag     3360

ggggaggtgt gggaggtttt ttagtcgact ggggagagat ctgaggaacc cctagtgatg     3420

gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc     3480

gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga     3540

gtggccaac                                                             3549


