                         SEQUENCE LISTING

<110>  ALLOGENE THERAPEUTICS, INC.
 
<120>  INDUCIBLE CHIMERIC CYTOKINE RECEPTORS

<130>  ALGN-016/01WO 333466-2243

<150>  US 62/637,600
<151>  2018-03-02

<160>  311   

<170>  PatentIn version 3.5

<210>  1
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-EpoR(237-508;L241G,L242P)-V5

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly 
                245                 250                 255     


Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu 
            260                 265                 270         


Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu 
        275                 280                 285             


Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser 
    290                 295                 300                 


Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu 
305                 310                 315                 320 


Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser 
                325                 330                 335     


Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro 
            340                 345                 350         


Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile Ser 
        355                 360                 365             


Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser 
    370                 375                 380                 


Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala 
385                 390                 395                 400 


Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser Ile Pro Asn Pro Leu 
                405                 410                 415     


Leu Gly Leu Asp Ser Thr 
            420         


<210>  2
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5-EpoR(273-508)-FKBP(F36V)-FKBP(F36V)

<400>  2

Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Ser His Arg Arg Ala 
1               5                   10                  15      


Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro Glu Ser Glu Phe 
            20                  25                  30          


Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln Leu Trp Leu Tyr 
        35                  40                  45              


Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr Pro Phe Thr Glu 
    50                  55                  60                  


Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg Cys Trp Gly Thr 
65                  70                  75                  80  


Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly Pro Leu Leu Glu 
                85                  90                  95      


Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu Val Leu Asp Lys 
            100                 105                 110         


Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu Pro Gly Pro Gly 
        115                 120                 125             


Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser Glu Ala Ser Ser 
    130                 135                 140                 


Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu Gly Ala Ser Ala 
145                 150                 155                 160 


Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser Gln Leu Leu Arg 
                165                 170                 175     


Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro Pro His Leu Lys 
            180                 185                 190         


Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile Ser Thr Asp Tyr Ser 
        195                 200                 205             


Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser Asp Gly Pro Tyr 
    210                 215                 220                 


Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala Glu Pro Leu Pro 
225                 230                 235                 240 


Pro Ser Tyr Val Ala Cys Ser Met Gly Val Gln Val Glu Thr Ile Ser 
                245                 250                 255     


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
            260                 265                 270         


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg 
        275                 280                 285             


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
    290                 295                 300                 


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
305                 310                 315                 320 


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
                325                 330                 335     


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
            340                 345                 350         


Lys Leu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
        355                 360                 365             


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
    370                 375                 380                 


Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
385                 390                 395                 400 


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
                405                 410                 415     


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
            420                 425                 430         


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
        435                 440                 445             


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    450                 455                 460     


<210>  3
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5-EpoR(273-508)-FKBP(E31G,36V,R71G,K105E)-FKBP(E31G,36V,R71G,K10
       5E)

<400>  3

Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Ser His Arg Arg Ala 
1               5                   10                  15      


Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro Glu Ser Glu Phe 
            20                  25                  30          


Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln Leu Trp Leu Tyr 
        35                  40                  45              


Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr Pro Phe Thr Glu 
    50                  55                  60                  


Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg Cys Trp Gly Thr 
65                  70                  75                  80  


Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly Pro Leu Leu Glu 
                85                  90                  95      


Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu Val Leu Asp Lys 
            100                 105                 110         


Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu Pro Gly Pro Gly 
        115                 120                 125             


Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser Glu Ala Ser Ser 
    130                 135                 140                 


Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu Gly Ala Ser Ala 
145                 150                 155                 160 


Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser Gln Leu Leu Arg 
                165                 170                 175     


Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro Pro His Leu Lys 
            180                 185                 190         


Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile Ser Thr Asp Tyr Ser 
        195                 200                 205             


Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser Asp Gly Pro Tyr 
    210                 215                 220                 


Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala Glu Pro Leu Pro 
225                 230                 235                 240 


Pro Ser Tyr Val Ala Cys Ser Met Gly Val Gln Val Glu Thr Ile Ser 
                245                 250                 255     


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
            260                 265                 270         


His Tyr Thr Gly Met Leu Gly Asp Gly Lys Lys Val Asp Ser Ser Arg 
        275                 280                 285             


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
    290                 295                 300                 


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Gly Ala 
305                 310                 315                 320 


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
                325                 330                 335     


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
            340                 345                 350         


Glu Leu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
        355                 360                 365             


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
    370                 375                 380                 


Gly Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
385                 390                 395                 400 


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
                405                 410                 415     


Val Ala Gln Met Ser Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro 
            420                 425                 430         


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
        435                 440                 445             


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Glu Leu Glu 
    450                 455                 460     


<210>  4
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-EpoR(237-338;L241G,L242P)-GHR(353-638)

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser 
                245                 250                 255     


Ser Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp 
            260                 265                 270         


Ser Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe 
        275                 280                 285             


Asn Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln 
    290                 295                 300                 


Arg Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln 
305                 310                 315                 320 


Asn Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser 
                325                 330                 335     


Val Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly 
            340                 345                 350         


Ala Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser 
        355                 360                 365             


Ser Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro 
    370                 375                 380                 


Ala Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met 
385                 390                 395                 400 


Ser Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn 
                405                 410                 415     


Phe Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys 
            420                 425                 430         


Ile Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser 
        435                 440                 445             


Leu Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala 
    450                 455                 460                 


Ala Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro 
465                 470                 475                 480 


Val Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu 
                485                 490                 495     


Ile Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser 
            500                 505                 510         


Ser Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
        515                 520                 525         


<210>  5
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL2Rb(333-551)

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala 
                245                 250                 255     


Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly 
            260                 265                 270         


Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln 
        275                 280                 285             


Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly 
    290                 295                 300                 


Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu 
305                 310                 315                 320 


Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu 
                325                 330                 335     


Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr 
            340                 345                 350         


Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu 
        355                 360                 365             


Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro 
    370                 375                 380                 


Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu 
385                 390                 395                 400 


Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu 
                405                 410                 415     


Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg 
            420                 425                 430         


Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
        435                 440                 445             


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    450                 455                 460 


<210>  6
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL7R(316-459)

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln 
                245                 250                 255     


Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser 
            260                 265                 270         


Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly 
        275                 280                 285             


Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp 
    290                 295                 300                 


Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly 
305                 310                 315                 320 


Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr 
                325                 330                 335     


Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu 
            340                 345                 350         


Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly 
        355                 360                 365             


Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
    370                 375                 380                 


Gln 
385 


<210>  7
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL12Rb2(714-862)

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp Pro Gln 
                245                 250                 255     


Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp Met Met 
            260                 265                 270         


His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala Glu Ser 
        275                 280                 285             


Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly Ser Asp 
    290                 295                 300                 


Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly 
305                 310                 315                 320 


Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu 
                325                 330                 335     


Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro 
            340                 345                 350         


Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His Pro Leu 
        355                 360                 365             


Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys Met Arg 
    370                 375                 380                 


Cys Asp Ser Leu Met Leu 
385                 390 


<210>  8
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL12Rb2(775-825)

<400>  8

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu 
                245                 250                 255     


Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile 
            260                 265                 270         


Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu 
        275                 280                 285             


Leu Glu Pro Gln 
    290         


<210>  9
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL21R(322-538)

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                245                 250                 255     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            260                 265                 270         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        275                 280                 285             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    290                 295                 300                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
305                 310                 315                 320 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                325                 330                 335     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            340                 345                 350         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        355                 360                 365             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    370                 375                 380                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
385                 390                 395                 400 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                405                 410                 415     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            420                 425                 430         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        435                 440                 445             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    450                 455             


<210>  10
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-EpoR(237-338;L241G,L242P)-IFNAR2(310-515)

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp Glu Ser Asp Ser 
                245                 250                 255     


Asp Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly Tyr Thr Met His 
            260                 265                 270         


Gly Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala Thr Ser Thr Glu 
        275                 280                 285             


Ser Gln Leu Ile Asp Pro Glu Ser Glu Glu Glu Pro Asp Leu Pro Glu 
    290                 295                 300                 


Val Asp Val Glu Leu Pro Thr Met Pro Lys Asp Ser Pro Gln Gln Leu 
305                 310                 315                 320 


Glu Leu Leu Ser Gly Pro Cys Glu Arg Arg Lys Ser Pro Leu Gln Asp 
                325                 330                 335     


Pro Phe Pro Glu Glu Asp Tyr Ser Ser Thr Glu Gly Ser Gly Gly Arg 
            340                 345                 350         


Ile Thr Phe Asn Val Asp Leu Asn Ser Val Phe Leu Arg Val Leu Asp 
        355                 360                 365             


Asp Glu Asp Ser Asp Asp Leu Glu Ala Pro Leu Met Leu Ser Ser His 
    370                 375                 380                 


Leu Glu Glu Met Val Asp Pro Glu Asp Pro Asp Asn Val Gln Ser Asn 
385                 390                 395                 400 


His Leu Leu Ala Ser Gly Glu Gly Thr Gln Pro Thr Phe Pro Ser Pro 
                405                 410                 415     


Ser Ser Glu Gly Leu Trp Ser Glu Asp Ala Pro Ser Asp Gln Ser Asp 
            420                 425                 430         


Thr Ser Glu Ser Asp Val Asp Leu Gly Asp Gly Tyr Ile Met Arg 
        435                 440                 445         


<210>  11
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-EpoR(237-338;L241G,L242P)-IFNAR1(300-520)

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Arg Gly Val Arg Pro Thr Pro Arg Val Arg Ala Pro Ala Thr Gln 
                245                 250                 255     


Gln Thr Arg Trp Lys Lys Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Asp Thr Glu Asp Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro 
        275                 280                 285             


Pro Ser Phe Leu Gly Gln Glu His Gln Ala Pro Gly His Ser Glu Ala 
    290                 295                 300                 


Gly Gly Val Asp Ser Gly Arg Pro Arg Ala Pro Leu Val Pro Ser Glu 
305                 310                 315                 320 


Gly Ser Ser Ala Trp Asp Ser Ser Asp Arg Ser Trp Ala Ser Thr Val 
                325                 330                 335     


Asp Ser Ser Trp Asp Arg Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys 
            340                 345                 350         


Gly Pro Gly Gln Gly Pro Gly Gly Asp Gly His Gln Glu Ser Leu Pro 
        355                 360                 365             


Pro Pro Glu Phe Ser Lys Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu 
    370                 375                 380                 


Asp Asn Leu Ser Ser Trp Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro 
385                 390                 395                 400 


Asn Leu Val Pro Gly Gly Pro Pro Val Ser Leu Gln Thr Leu Thr Phe 
                405                 410                 415     


Cys Trp Glu Ser Ser Pro Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu 
            420                 425                 430         


Ile Glu Asp Ser Asp Ala Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg 
        435                 440                 445             


Thr Glu Asp Arg Gly Arg Thr Leu Gly His Tyr Met Ala Arg 
    450                 455                 460         


<210>  12
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 
       SS-Myc-FKBP(F36V)-muEpoR(236-337;L264G,L265P)-muIL2Rb(337-539)

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Ala Ser 
    130                 135                 140                 


Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Leu Ile Ser Leu Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Thr Leu Gln Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Leu Gln Arg Asp Gly Cys Leu Trp Trp Ser Pro Gly Ser 
    210                 215                 220                 


Ser Phe Pro Glu Asp Pro Pro Ala His Leu Glu Val Leu Ser Glu Pro 
225                 230                 235                 240 


Arg Ala Val Gln Leu Leu Leu Leu Gln Lys Asp Ser Ala Pro Leu Pro 
                245                 250                 255     


Ser Pro Ser Gly His Ser Gln Ala Ser Cys Phe Thr Asn Gln Gly Tyr 
            260                 265                 270         


Phe Phe Phe His Leu Pro Asn Ala Leu Glu Ile Glu Ser Cys Gln Val 
        275                 280                 285             


Tyr Phe Thr Tyr Asp Pro Cys Val Glu Glu Glu Val Glu Glu Asp Gly 
    290                 295                 300                 


Ser Arg Leu Pro Glu Gly Ser Pro His Pro Pro Leu Leu Pro Leu Ala 
305                 310                 315                 320 


Gly Glu Gln Asp Asp Tyr Cys Ala Phe Pro Pro Arg Asp Asp Leu Leu 
                325                 330                 335     


Leu Phe Ser Pro Ser Leu Ser Thr Pro Asn Thr Ala Tyr Gly Gly Ser 
            340                 345                 350         


Arg Ala Pro Glu Glu Arg Ser Pro Leu Ser Leu His Glu Gly Leu Pro 
        355                 360                 365             


Ser Leu Ala Ser Arg Asp Leu Met Gly Leu Gln Arg Pro Leu Glu Arg 
    370                 375                 380                 


Met Pro Glu Gly Asp Gly Glu Gly Leu Ser Ala Asn Ser Ser Gly Glu 
385                 390                 395                 400 


Gln Ala Ser Val Pro Glu Gly Asn Leu His Gly Gln Asp Gln Asp Arg 
                405                 410                 415     


Gly Gln Gly Pro Ile Leu Thr Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
            420                 425                 430         


Gln Glu Leu Gln Ala Gln Asp Ser Val His Leu Ile 
        435                 440                 


<210>  13
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-muEpoR(236-337;L264G,L265P)-muIL7R(316-459)

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Ala Ser 
    130                 135                 140                 


Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Leu Ile Ser Leu Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Thr Leu Gln Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Leu Gln Arg Asp Gly Cys Leu Trp Trp Ser Pro Gly Ser 
    210                 215                 220                 


Ser Phe Pro Glu Asp Pro Pro Ala His Leu Glu Val Leu Ser Glu Pro 
225                 230                 235                 240 


Arg Ala Arg Asp Glu Val Glu Ser Phe Leu Pro Asn Asp Leu Pro Ala 
                245                 250                 255     


Gln Pro Glu Glu Leu Glu Thr Gln Gly His Arg Ala Ala Val His Ser 
            260                 265                 270         


Ala Asn Arg Ser Pro Glu Thr Ser Val Ser Pro Pro Glu Thr Val Arg 
        275                 280                 285             


Arg Glu Ser Pro Leu Arg Cys Leu Ala Arg Asn Leu Ser Thr Cys Asn 
    290                 295                 300                 


Ala Pro Pro Leu Leu Ser Ser Arg Ser Pro Asp Tyr Arg Asp Gly Asp 
305                 310                 315                 320 


Arg Asn Arg Pro Pro Val Tyr Gln Asp Leu Leu Pro Asn Ser Gly Asn 
                325                 330                 335     


Thr Asn Val Pro Val Pro Val Pro Gln Pro Leu Pro Phe Gln Ser Gly 
            340                 345                 350         


Ile Leu Ile Pro Val Ser Gln Arg Gln Pro Ile Ser Thr Ser Ser Val 
        355                 360                 365             


Leu Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
    370                 375                 380                 


Lys 
385 


<210>  14
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 
       SS-Myc-FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL7R(316-459)-IL12Rb2
       (775-825)

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln 
                245                 250                 255     


Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser 
            260                 265                 270         


Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly 
        275                 280                 285             


Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp 
    290                 295                 300                 


Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly 
305                 310                 315                 320 


Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr 
                325                 330                 335     


Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu 
            340                 345                 350         


Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly 
        355                 360                 365             


Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
    370                 375                 380                 


Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu 
385                 390                 395                 400 


Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile 
                405                 410                 415     


Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu 
            420                 425                 430         


Leu Glu Pro Gln 
        435     


<210>  15
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 
       SS-Myc-FKBP(F36V)-GP130(609-700)-IL7R(316-459)-IL12Rb2(775-825)

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Thr Thr Pro Lys Phe 
    130                 135                 140                 


Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val Cys Leu Ala Phe 
145                 150                 155                 160 


Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe Asn Lys Arg Asp 
                165                 170                 175     


Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp Pro Ser Lys Ser 
            180                 185                 190         


His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg His Asn Phe Asn 
        195                 200                 205             


Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr Asp Val Ser Val 
    210                 215                 220                 


Val Glu Ile Glu Ala Asn Asp Ala Arg Asp Glu Val Glu Gly Phe Leu 
225                 230                 235                 240 


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
                245                 250                 255     


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
            260                 265                 270         


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
        275                 280                 285             


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
    290                 295                 300                 


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
                325                 330                 335     


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
            340                 345                 350         


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
        355                 360                 365             


Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala 
    370                 375                 380                 


Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly 
385                 390                 395                 400 


Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu 
                405                 410                 415     


Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425     


<210>  16
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-PrlR(221-319)-IL7R(316-459)-IL12Rb2(775-825)

<400>  16

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ala Thr Phe Ile Gln 
    130                 135                 140                 


Ile Pro Ser Asp Phe Thr Met Asn Asp Thr Thr Val Trp Ile Ser Val 
145                 150                 155                 160 


Ala Val Leu Ser Ala Val Ile Cys Leu Ile Ile Val Trp Ala Val Ala 
                165                 170                 175     


Leu Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro Gly 
            180                 185                 190         


Pro Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys Ser 
        195                 200                 205             


Glu Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr Ser 
    210                 215                 220                 


Asp Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ala Arg 
225                 230                 235                 240 


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
                245                 250                 255     


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
            260                 265                 270         


Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser 
        275                 280                 285             


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
    290                 295                 300                 


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
305                 310                 315                 320 


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
                325                 330                 335     


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
            340                 345                 350         


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
        355                 360                 365             


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp 
    370                 375                 380                 


Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly 
385                 390                 395                 400 


Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu 
                405                 410                 415     


Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro 
            420                 425                 430         


Gln 
    


<210>  17
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-GHR(251-352)-IL7R(316-459)-IL12Rb2(775-825)

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Leu Pro Gln Met Ser 
    130                 135                 140                 


Gln Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile 
145                 150                 155                 160 


Ile Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe 
                165                 170                 175     


Ser Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val 
            180                 185                 190         


Pro Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu 
        195                 200                 205             


Glu Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu 
    210                 215                 220                 


Phe His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp 
225                 230                 235                 240 


Glu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln 
                245                 250                 255     


Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser 
            260                 265                 270         


Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly 
        275                 280                 285             


Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp 
    290                 295                 300                 


Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly 
305                 310                 315                 320 


Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr 
                325                 330                 335     


Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu 
            340                 345                 350         


Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly 
        355                 360                 365             


Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
    370                 375                 380                 


Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu 
385                 390                 395                 400 


Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile 
                405                 410                 415     


Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu 
            420                 425                 430         


Leu Glu Pro Gln 
        435     


<210>  18
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-GCSFR(614-710)-IL7R(316-459)-IL12Rb2(775-825)

<400>  18

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Leu Thr Leu Met Thr 
    130                 135                 140                 


Leu Thr Pro Glu Gly Ser Glu Leu His Ile Ile Leu Gly Leu Phe Gly 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Thr Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys 
                165                 170                 175     


Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
            180                 185                 190         


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
        195                 200                 205             


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
    210                 215                 220                 


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ala Arg Asp Glu 
225                 230                 235                 240 


Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser 
                245                 250                 255     


Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser 
            260                 265                 270         


Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu 
        275                 280                 285             


Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser 
    290                 295                 300                 


Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His 
305                 310                 315                 320 


Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu 
                325                 330                 335     


Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val 
            340                 345                 350         


Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu 
        355                 360                 365             


Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys 
    370                 375                 380                 


Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu 
385                 390                 395                 400 


Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser 
                405                 410                 415     


His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425                 430     


<210>  19
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)-TPOR/MPLR(478-582)-IL7R(316-459)-IL12Rb2(775-825)

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr Arg 
    130                 135                 140                 


Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu 
145                 150                 155                 160 


His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg 
                165                 170                 175     


Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro 
            180                 185                 190         


Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr 
        195                 200                 205             


Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu 
    210                 215                 220                 


Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr 
225                 230                 235                 240 


Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr 
                245                 250                 255     


Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp 
            260                 265                 270         


Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu 
        275                 280                 285             


Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser 
    290                 295                 300                 


Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg 
305                 310                 315                 320 


Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser 
                325                 330                 335     


Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser 
            340                 345                 350         


Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr 
        355                 360                 365             


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
    370                 375                 380                 


Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp 
385                 390                 395                 400 


Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro 
                405                 410                 415     


Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser 
            420                 425                 430         


Leu Glu Glu Leu Glu Pro Gln 
        435                 


<210>  20
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(376-416)

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
                245                 250                 255     


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
            260                 265                 270         


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
        275                 280         


<210>  21
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(424-459)

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                245                 250                 255     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            260                 265                 270         


Phe Tyr Gln Asn Gln 
        275         


<210>  22
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(376-416,424-459)

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
                245                 250                 255     


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
            260                 265                 270         


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Gln Gly Gln Pro Ile Leu 
        275                 280                 285             


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
    290                 295                 300                 


Phe Tyr Gln Asn Gln 
305                 


<210>  23
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(424-459;Y456F)

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                245                 250                 255     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            260                 265                 270         


Phe Phe Gln Asn Gln 
        275         


<210>  24
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(376-416,424-459;Y456F)

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
                245                 250                 255     


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
            260                 265                 270         


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Gln Gly Gln Pro Ile Leu 
        275                 280                 285             


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
    290                 295                 300                 


Phe Phe Gln Asn Gln 
305                 


<210>  25
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(393-433)

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro 
                245                 250                 255     


Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser 
            260                 265                 270         


Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser 
        275                 280         


<210>  26
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(518-551)

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn 
                245                 250                 255     


Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr 
            260                 265                 270         


His Leu Val 
        275 


<210>  27
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(339-379,393-433)

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His 
                245                 250                 255     


Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu 
            260                 265                 270         


Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu Gly Val Ala Gly 
        275                 280                 285             


Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu 
    290                 295                 300                 


Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe 
305                 310                 315                 320 


Ser Pro Ser 
            


<210>  28
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(339-379,518-551)

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His 
                245                 250                 255     


Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu 
            260                 265                 270         


Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Gly Gln Gly Glu Phe Arg 
        275                 280                 285             


Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
    290                 295                 300                 


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
305                 310                 315     


<210>  29
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(393-433,518-551)

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro 
                245                 250                 255     


Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser 
            260                 265                 270         


Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg 
        275                 280                 285             


Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
    290                 295                 300                 


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
305                 310                 315     


<210>  30
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(339-379,393-433,518-551)

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His 
                245                 250                 255     


Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu 
            260                 265                 270         


Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu Gly Val Ala Gly 
        275                 280                 285             


Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu 
    290                 295                 300                 


Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe 
305                 310                 315                 320 


Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro 
                325                 330                 335     


Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp 
            340                 345                 350         


Pro Thr His Leu Val 
        355         


<210>  31
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(955-1186)

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp 
                245                 250                 255     


Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val 
            260                 265                 270         


Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser 
        275                 280                 285             


Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala Thr Ser 
    290                 295                 300                 


Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln Ser Cys 
305                 310                 315                 320 


Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp Pro Thr 
                325                 330                 335     


Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro Val Pro 
            340                 345                 350         


Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser Val Gln 
        355                 360                 365             


Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser Arg Asp 
    370                 375                 380                 


Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro Glu Tyr 
385                 390                 395                 400 


Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp Ser Pro 
                405                 410                 415     


Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro 
            420                 425                 430         


Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile 
        435                 440                 445             


Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro 
    450                 455                 460                 


Gln Ser Ser Glu Phe Ile Gly Ala 
465                 470         


<210>  32
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(955-1044,1058-1186;Y974F)

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp 
                245                 250                 255     


Ser Asn Phe Phe Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val 
            260                 265                 270         


Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser 
        275                 280                 285             


Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala Thr Ser 
    290                 295                 300                 


Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln Ser Cys 
305                 310                 315                 320 


Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Ile Asp Asp Thr Phe Leu 
                325                 330                 335     


Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly 
            340                 345                 350         


Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro 
        355                 360                 365             


Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn 
    370                 375                 380                 


Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe 
385                 390                 395                 400 


Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu 
                405                 410                 415     


Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro 
            420                 425                 430         


Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg 
        435                 440                 445             


Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
    450                 455                 


<210>  33
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(955-1009;Y974F)

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp 
                245                 250                 255     


Ser Asn Phe Phe Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val 
            260                 265                 270         


Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser 
        275                 280                 285             


Pro Ser Thr Ser Arg Thr Pro 
    290                 295 


<210>  34
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1019-1085)

<400>  34

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln Ser 
                245                 250                 255     


Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Ile Asp Asp Thr Phe 
            260                 265                 270         


Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala 
        275                 280                 285             


Gly Ser Val Gln Asn Pro Val 
    290                 295 


<210>  35
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1037-1044,1058-1103;Y1068/1101F)

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Lys Glu Asp Ser Phe Leu Gln Arg Ile Asp Asp Thr Phe Leu Pro 
                245                 250                 255     


Val Pro Glu Phe Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser 
            260                 265                 270         


Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser 
        275                 280                 285             


Arg Asp Pro His Phe Gln Asp 
    290                 295 


<210>  36
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1066-1118;Y1068/1086F)

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Val Pro Glu Phe Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly 
                245                 250                 255     


Ser Val Gln Asn Pro Val Phe His Asn Gln Pro Leu Asn Pro Ala Pro 
            260                 265                 270         


Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn 
        275                 280                 285             


Pro Glu Tyr Leu Asn Thr Val 
    290                 295 


<210>  37
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1122-1165)

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr 
                245                 250                 255     


Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser 
            260                 265                 270         


Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys 
        275                 280                 285             


Pro Asn Gly Ile Phe Lys Gly 
    290                 295 


<210>  38
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1133-1186;Y1148F)

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro Asp 
                245                 250                 255     


Phe Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile Phe 
            260                 265                 270         


Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln 
        275                 280                 285             


Ser Ser Glu Phe Ile Gly Ala 
    290                 295 


<210>  39
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-BLNK(53-208)

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp Asp 
                245                 250                 255     


Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp Ser Glu Met 
            260                 265                 270         


Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr Glu Pro Pro 
        275                 280                 285             


Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe Ala 
    290                 295                 300                 


Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro Pro 
305                 310                 315                 320 


Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys Ala 
                325                 330                 335     


Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro Gln 
            340                 345                 350         


Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr Val 
        355                 360                 365             


Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu Ser 
    370                 375                 380                 


Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
385                 390                 395         


<210>  40
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-BLNK(53-208;Y72F)

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp Asp 
                245                 250                 255     


Phe Asp Ser Asp Phe Glu Asn Pro Asp Glu His Ser Asp Ser Glu Met 
            260                 265                 270         


Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr Glu Pro Pro 
        275                 280                 285             


Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe Ala 
    290                 295                 300                 


Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro Pro 
305                 310                 315                 320 


Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys Ala 
                325                 330                 335     


Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro Gln 
            340                 345                 350         


Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr Val 
        355                 360                 365             


Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu Ser 
    370                 375                 380                 


Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
385                 390                 395         


<210>  41
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-Myc-FKBP(F36V)- EpoR(237-338;L241G,L242P)-BLNK(53-208;Y72F,Y96F)

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        35                  40                  45              


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    50                  55                  60                  


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
65                  70                  75                  80  


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                85                  90                  95      


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            100                 105                 110         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        115                 120                 125             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val Ser 
    130                 135                 140                 


Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu 
145                 150                 155                 160 


Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu Ser 
                165                 170                 175     


His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
            180                 185                 190         


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
        195                 200                 205             


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
    210                 215                 220                 


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
225                 230                 235                 240 


Cys Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp Asp 
                245                 250                 255     


Phe Asp Ser Asp Phe Glu Asn Pro Asp Glu His Ser Asp Ser Glu Met 
            260                 265                 270         


Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Phe Glu Pro Pro 
        275                 280                 285             


Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe Ala 
    290                 295                 300                 


Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro Pro 
305                 310                 315                 320 


Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys Ala 
                325                 330                 335     


Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro Gln 
            340                 345                 350         


Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr Val 
        355                 360                 365             


Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu Ser 
    370                 375                 380                 


Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
385                 390                 395         


<210>  42
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
225                 230                 235                 240 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
                245                 250                 255     


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
            260                 265                 270         


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
        275                 280                 285             


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
    290                 295                 300                 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
305                 310                 315                 320 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
                325                 330                 335     


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
            340                 345                 350         


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
        355                 360                 365             


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    370                 375             


<210>  43
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rb(333-551)

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Val Thr Gln Leu Leu Leu 
225                 230                 235                 240 


Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser 
                245                 250                 255     


Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro 
            260                 265                 270         


Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro 
        275                 280                 285             


Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro Thr Gly 
    290                 295                 300                 


Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr 
305                 310                 315                 320 


Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu 
                325                 330                 335     


Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala 
            340                 345                 350         


Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp 
        355                 360                 365             


Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu 
    370                 375                 380                 


Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu 
385                 390                 395                 400 


Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser 
                405                 410                 415     


Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro 
            420                 425                 430         


Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp 
        435                 440                 445             


Pro Thr His Leu Val 
    450             


<210>  44
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(393-433,518-551)

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Asp Glu Gly Val Ala Gly 
225                 230                 235                 240 


Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu 
                245                 250                 255     


Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe 
            260                 265                 270         


Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro 
        275                 280                 285             


Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp 
    290                 295                 300                 


Pro Thr His Leu Val 
305                 


<210>  45
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(339-379,393-433,518-551)

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Gln Gln Asp Lys Val Pro 
225                 230                 235                 240 


Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr 
                245                 250                 255     


Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu 
            260                 265                 270         


Ala Cys Gln Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro 
        275                 280                 285             


Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe 
    290                 295                 300                 


Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu 
305                 310                 315                 320 


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
                325                 330                 335     


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
            340                 345                 350 


<210>  46
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)-IL12Rb2(775-825)

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
225                 230                 235                 240 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
                245                 250                 255     


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
            260                 265                 270         


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
        275                 280                 285             


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
    290                 295                 300                 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
305                 310                 315                 320 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
                325                 330                 335     


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
            340                 345                 350         


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
        355                 360                 365             


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu 
    370                 375                 380                 


Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr 
385                 390                 395                 400 


His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu 
                405                 410                 415     


Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425                 


<210>  47
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)-IL21R(322-538)

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
225                 230                 235                 240 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
                245                 250                 255     


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
            260                 265                 270         


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
        275                 280                 285             


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
    290                 295                 300                 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
305                 310                 315                 320 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
                325                 330                 335     


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
            340                 345                 350         


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
        355                 360                 365             


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Pro Arg Ser Pro Ala Lys 
    370                 375                 380                 


Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser 
385                 390                 395                 400 


Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly 
                405                 410                 415     


Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser 
            420                 425                 430         


Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro 
        435                 440                 445             


Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly 
    450                 455                 460                 


Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr 
465                 470                 475                 480 


Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly 
                485                 490                 495     


Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp 
            500                 505                 510         


Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly 
        515                 520                 525             


Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met 
    530                 535                 540                 


Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val 
545                 550                 555                 560 


Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr 
                565                 570                 575     


Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro 
            580                 585                 590         


Gln Ala Ser 
        595 


<210>  48
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)- IL21R(322-538)-IL7R(316-459)

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Pro Arg Ser Pro Ala Lys 
225                 230                 235                 240 


Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser 
                245                 250                 255     


Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly 
            260                 265                 270         


Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser 
        275                 280                 285             


Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro 
    290                 295                 300                 


Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly 
305                 310                 315                 320 


Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr 
                325                 330                 335     


Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly 
            340                 345                 350         


Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp 
        355                 360                 365             


Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly 
    370                 375                 380                 


Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met 
385                 390                 395                 400 


Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val 
                405                 410                 415     


Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr 
            420                 425                 430         


Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro 
        435                 440                 445             


Gln Ala Ser Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    450                 455                 460                 


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
465                 470                 475                 480 


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                485                 490                 495     


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            500                 505                 510         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        515                 520                 525             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    530                 535                 540                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
545                 550                 555                 560 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                565                 570                 575     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            580                 585                 590         


Gln Asn Gln 
        595 


<210>  49
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(393-433,518-551)-IL21R(322-538)

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Asp Glu Gly Val Ala Gly 
225                 230                 235                 240 


Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu 
                245                 250                 255     


Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe 
            260                 265                 270         


Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro 
        275                 280                 285             


Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp 
    290                 295                 300                 


Pro Thr His Leu Val Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr 
305                 310                 315                 320 


Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys 
                325                 330                 335     


Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser 
            340                 345                 350         


Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr 
        355                 360                 365             


Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp 
    370                 375                 380                 


Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro 
385                 390                 395                 400 


Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys 
                405                 410                 415     


Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser 
            420                 425                 430         


Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala 
        435                 440                 445             


Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser 
    450                 455                 460                 


Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser 
465                 470                 475                 480 


Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr 
                485                 490                 495     


Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val 
            500                 505                 510         


Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
        515                 520                 525     


<210>  50
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)- IL21R(322-538)-IL2Rbsmall(393-433,518-551)

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Pro Arg Ser Pro Ala Lys 
225                 230                 235                 240 


Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser 
                245                 250                 255     


Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly 
            260                 265                 270         


Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser 
        275                 280                 285             


Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro 
    290                 295                 300                 


Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly 
305                 310                 315                 320 


Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr 
                325                 330                 335     


Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly 
            340                 345                 350         


Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp 
        355                 360                 365             


Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly 
    370                 375                 380                 


Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met 
385                 390                 395                 400 


Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val 
                405                 410                 415     


Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr 
            420                 425                 430         


Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro 
        435                 440                 445             


Gln Ala Ser Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro 
    450                 455                 460                 


Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe 
465                 470                 475                 480 


Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu 
                485                 490                 495     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            500                 505                 510         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 525     


<210>  51
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(339-379,393-433,518-551)-IL21R(322-538)

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Gln Gln Asp Lys Val Pro 
225                 230                 235                 240 


Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr 
                245                 250                 255     


Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu 
            260                 265                 270         


Ala Cys Gln Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro 
        275                 280                 285             


Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe 
    290                 295                 300                 


Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu 
305                 310                 315                 320 


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
                325                 330                 335     


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Pro Arg 
            340                 345                 350         


Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala Glu 
        355                 360                 365             


Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr Ala 
    370                 375                 380                 


Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr 
385                 390                 395                 400 


Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro 
                405                 410                 415     


Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp 
            420                 425                 430         


Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu 
        435                 440                 445             


Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser 
    450                 455                 460                 


Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro 
465                 470                 475                 480 


Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly 
                485                 490                 495     


Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala 
            500                 505                 510         


Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys 
        515                 520                 525             


Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro 
    530                 535                 540                 


Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Pro Gly Pro Gln Ala Ser 
                565         


<210>  52
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)- IL21R(322-538)-IL2Rbsmall(339-379,393-433,518-551)

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Pro Arg Ser Pro Ala Lys 
225                 230                 235                 240 


Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser 
                245                 250                 255     


Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly 
            260                 265                 270         


Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser 
        275                 280                 285             


Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro 
    290                 295                 300                 


Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly 
305                 310                 315                 320 


Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr 
                325                 330                 335     


Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly 
            340                 345                 350         


Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp 
        355                 360                 365             


Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly 
    370                 375                 380                 


Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met 
385                 390                 395                 400 


Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val 
                405                 410                 415     


Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr 
            420                 425                 430         


Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro 
        435                 440                 445             


Gln Ala Ser Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser 
    450                 455                 460                 


Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe 
465                 470                 475                 480 


His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu Gly Val 
                485                 490                 495     


Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser 
            500                 505                 510         


Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu 
        515                 520                 525             


Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
    530                 535                 540                 


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
545                 550                 555                 560 


Gln Asp Pro Thr His Leu Val 
                565         


<210>  53
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(393-433,518-551)-IL7R(316-459)

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Asp Glu Gly Val Ala Gly 
225                 230                 235                 240 


Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu 
                245                 250                 255     


Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe 
            260                 265                 270         


Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro 
        275                 280                 285             


Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp 
    290                 295                 300                 


Pro Thr His Leu Val Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
305                 310                 315                 320 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
                325                 330                 335     


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
            340                 345                 350         


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
        355                 360                 365             


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
    370                 375                 380                 


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
385                 390                 395                 400 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
                405                 410                 415     


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
            420                 425                 430         


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
        435                 440                 445             


Phe Tyr Gln Asn Gln 
    450             


<210>  54
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)-IL2Rbsmall(393-433,518-551)

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
225                 230                 235                 240 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
                245                 250                 255     


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
            260                 265                 270         


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
        275                 280                 285             


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
    290                 295                 300                 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
305                 310                 315                 320 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
                325                 330                 335     


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
            340                 345                 350         


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
        355                 360                 365             


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Asp Glu Gly Val Ala Gly 
    370                 375                 380                 


Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu 
385                 390                 395                 400 


Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe 
                405                 410                 415     


Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro 
            420                 425                 430         


Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp 
        435                 440                 445             


Pro Thr His Leu Val 
    450             


<210>  55
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)- IL2Rbsmall(339-379,393-433,518-551)-IL7R(316-459)

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Gln Gln Asp Lys Val Pro 
225                 230                 235                 240 


Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr 
                245                 250                 255     


Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu 
            260                 265                 270         


Ala Cys Gln Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro 
        275                 280                 285             


Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe 
    290                 295                 300                 


Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu 
305                 310                 315                 320 


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
                325                 330                 335     


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Ala Arg 
            340                 345                 350         


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
        355                 360                 365             


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
    370                 375                 380                 


Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
                405                 410                 415     


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
            420                 425                 430         


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
        435                 440                 445             


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
    450                 455                 460                 


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
465                 470                 475                 480 


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
                485                 490                 


<210>  56
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)- IL2Rbsmall(339-379,393-433,518-551)

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
225                 230                 235                 240 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
                245                 250                 255     


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
            260                 265                 270         


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
        275                 280                 285             


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
    290                 295                 300                 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
305                 310                 315                 320 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
                325                 330                 335     


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
            340                 345                 350         


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
        355                 360                 365             


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Gln Gln Asp Lys Val Pro 
    370                 375                 380                 


Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr 
385                 390                 395                 400 


Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu 
                405                 410                 415     


Ala Cys Gln Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro 
            420                 425                 430         


Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe 
        435                 440                 445             


Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu 
    450                 455                 460                 


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
465                 470                 475                 480 


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                485                 490                 


<210>  57
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)-PD1(156-191)-TPOR/MPLR (514-582)-IL7R(316-459)-IL12Rb2(775-825)

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val 
    130                 135                 140                 


Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp 
145                 150                 155                 160 


Val Leu Ala Val Ile Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
225                 230                 235                 240 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
                245                 250                 255     


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
            260                 265                 270         


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
        275                 280                 285             


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
    290                 295                 300                 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
305                 310                 315                 320 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
                325                 330                 335     


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
            340                 345                 350         


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
        355                 360                 365             


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu 
    370                 375                 380                 


Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr 
385                 390                 395                 400 


His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu 
                405                 410                 415     


Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425                 


<210>  58
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SS-FKBP(F36V)- TPOR/MPLR(478-582)-EGFR(1122-1165)

<400>  58

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Pro Glu Tyr Leu Asn Thr 
225                 230                 235                 240 


Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp Ser Pro Ala His Trp 
                245                 250                 255     


Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln 
            260                 265                 270         


Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile Phe Lys Gly 
        275                 280                 285             


<210>  59
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Asp His Leu Gly Ala Ser Leu Trp Pro Gln Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Leu Pro Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Gly Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Asp Glu Pro Trp Lys Leu Cys Arg Leu His Gln Ala 
                85                  90                  95      


Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Ser 
        115                 120                 125             


Gly Ala Pro Arg Tyr His Arg Val Ile His Ile Asn Glu Val Val Leu 
    130                 135                 140                 


Leu Asp Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly 
145                 150                 155                 160 


His Val Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser 
                165                 170                 175     


His Ile Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser 
            180                 185                 190         


Val Gln Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser 
        195                 200                 205             


Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val 
225                 230                 235                 240 


Ser Leu Leu Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
                245                 250                 255     


Leu Ile Leu Val Val Ile Leu Val Leu Leu Thr Val Leu Ala Leu Leu 
            260                 265                 270         


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
        275                 280                 285             


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
    290                 295                 300                 


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
305                 310                 315                 320 


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
                325                 330                 335     


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
            340                 345                 350         


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
        355                 360                 365             


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
    370                 375                 380                 


Leu Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
385                 390                 395                 400 


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
                405                 410                 415     


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
            420                 425                 430         


Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr 
        435                 440                 445             


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
    450                 455                 460                 


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
465                 470                 475                 480 


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
                485                 490                 495     


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
            500                 505             


<210>  60
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Arg Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Val Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  61
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Lys Glu Asn Val Ala Ser Ala Thr Val Phe Thr Leu Leu Leu Phe 
1               5                   10                  15      


Leu Asn Thr Cys Leu Leu Asn Gly Gln Leu Pro Pro Gly Lys Pro Glu 
            20                  25                  30          


Ile Phe Lys Cys Arg Ser Pro Asn Lys Glu Thr Phe Thr Cys Trp Trp 
        35                  40                  45              


Arg Pro Gly Thr Asp Gly Gly Leu Pro Thr Asn Tyr Ser Leu Thr Tyr 
    50                  55                  60                  


His Arg Glu Gly Glu Thr Leu Met His Glu Cys Pro Asp Tyr Ile Thr 
65                  70                  75                  80  


Gly Gly Pro Asn Ser Cys His Phe Gly Lys Gln Tyr Thr Ser Met Trp 
                85                  90                  95      


Arg Thr Tyr Ile Met Met Val Asn Ala Thr Asn Gln Met Gly Ser Ser 
            100                 105                 110         


Phe Ser Asp Glu Leu Tyr Val Asp Val Thr Tyr Ile Val Gln Pro Asp 
        115                 120                 125             


Pro Pro Leu Glu Leu Ala Val Glu Val Lys Gln Pro Glu Asp Arg Lys 
    130                 135                 140                 


Pro Tyr Leu Trp Ile Lys Trp Ser Pro Pro Thr Leu Ile Asp Leu Lys 
145                 150                 155                 160 


Thr Gly Trp Phe Thr Leu Leu Tyr Glu Ile Arg Leu Lys Pro Glu Lys 
                165                 170                 175     


Ala Ala Glu Trp Glu Ile His Phe Ala Gly Gln Gln Thr Glu Phe Lys 
            180                 185                 190         


Ile Leu Ser Leu His Pro Gly Gln Lys Tyr Leu Val Gln Val Arg Cys 
        195                 200                 205             


Lys Pro Asp His Gly Tyr Trp Ser Ala Trp Ser Pro Ala Thr Phe Ile 
    210                 215                 220                 


Gln Ile Pro Ser Asp Phe Thr Met Asn Asp Thr Thr Val Trp Ile Ser 
225                 230                 235                 240 


Val Ala Val Leu Ser Ala Val Ile Cys Leu Ile Ile Val Trp Ala Val 
                245                 250                 255     


Ala Leu Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro 
            260                 265                 270         


Gly Pro Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys 
        275                 280                 285             


Ser Glu Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr 
    290                 295                 300                 


Ser Asp Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ser 
305                 310                 315                 320 


Glu Asp Gln His Leu Met Ser Val His Ser Lys Glu His Pro Ser Gln 
                325                 330                 335     


Gly Met Lys Pro Thr Tyr Leu Asp Pro Asp Thr Asp Ser Gly Arg Gly 
            340                 345                 350         


Ser Cys Asp Ser Pro Ser Leu Leu Ser Glu Lys Cys Glu Glu Pro Gln 
        355                 360                 365             


Ala Asn Pro Ser Thr Phe Tyr Asp Pro Glu Val Ile Glu Lys Pro Glu 
    370                 375                 380                 


Asn Pro Glu Thr Thr His Thr Trp Asp Pro Gln Cys Ile Ser Met Glu 
385                 390                 395                 400 


Gly Lys Ile Pro Tyr Phe His Ala Gly Gly Ser Lys Cys Ser Thr Trp 
                405                 410                 415     


Pro Leu Pro Gln Pro Ser Gln His Asn Pro Arg Ser Ser Tyr His Asn 
            420                 425                 430         


Ile Thr Asp Val Cys Glu Leu Ala Val Gly Pro Ala Gly Ala Pro Ala 
        435                 440                 445             


Thr Leu Leu Asn Glu Ala Gly Lys Asp Ala Leu Lys Ser Ser Gln Thr 
    450                 455                 460                 


Ile Lys Ser Arg Glu Glu Gly Lys Ala Thr Gln Gln Arg Glu Val Glu 
465                 470                 475                 480 


Ser Phe His Ser Glu Thr Asp Gln Asp Thr Pro Trp Leu Leu Pro Gln 
                485                 490                 495     


Glu Lys Thr Pro Phe Gly Ser Ala Lys Pro Leu Asp Tyr Val Glu Ile 
            500                 505                 510         


His Lys Val Asn Lys Asp Gly Ala Leu Ser Leu Leu Pro Lys Gln Arg 
        515                 520                 525             


Glu Asn Ser Gly Lys Pro Lys Lys Pro Gly Thr Pro Glu Asn Asn Lys 
    530                 535                 540                 


Glu Tyr Ala Lys Val Ser Gly Val Met Asp Asn Asn Ile Leu Val Leu 
545                 550                 555                 560 


Val Pro Asp Pro His Ala Lys Asn Val Ala Cys Phe Glu Glu Ser Ala 
                565                 570                 575     


Lys Glu Ala Pro Pro Ser Leu Glu Gln Asn Gln Ala Glu Lys Ala Leu 
            580                 585                 590         


Ala Asn Phe Thr Ala Thr Ser Ser Lys Cys Arg Leu Gln Leu Gly Gly 
        595                 600                 605             


Leu Asp Tyr Leu Asp Pro Ala Cys Phe Thr His Ser Phe His 
    610                 615                 620         


<210>  62
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Pro Trp Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Ser Gln 
                245                 250                 255     


Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile 
            260                 265                 270         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        275                 280                 285             


Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
    290                 295                 300                 


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
305                 310                 315                 320 


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
                325                 330                 335     


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
            340                 345                 350         


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
        355                 360                 365             


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
    370                 375                 380                 


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
385                 390                 395                 400 


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
                405                 410                 415     


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
            420                 425                 430         


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
        435                 440                 445             


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
    450                 455                 460                 


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
465                 470                 475                 480 


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
                485                 490                 495     


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
            500                 505                 510         


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
        515                 520                 525             


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
    530                 535                 540                 


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
545                 550                 555                 560 


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
                565                 570                 575     


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
            580                 585                 590         


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
        595                 600                 605             


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
    610                 615                 620                 


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
625                 630                 635             


<210>  63
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Leu Pro Gly Pro Arg Gln Gly Gln 
        675                 680                 685             


Trp Leu Gly Gln Thr Ser Glu Met Ser Arg Ala Leu Thr Pro His Pro 
    690                 695                 700                 


Cys Val Gln Asp Ala Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile 
705                 710                 715                 720 


Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp 
                725                 730                 735     


Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln 
            740                 745                 750         


Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln 
        755                 760                 765             


Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr Gly Gln Leu Leu Gly 
    770                 775                 780                 


Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu Arg Cys Asp Ser Thr 
785                 790                 795                 800 


Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro Lys Ser Tyr Glu Asn 
                805                 810                 815     


Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu Val Thr Pro Ala Pro 
            820                 825                 830         


Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu Leu Asn Phe Pro Leu 
        835                 840                 845             


Leu Gln Gly Ile Arg Val His Gly Met Glu Ala Leu Gly Ser Phe 
    850                 855                 860             


<210>  64
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Gln Asp Val Ser Leu Leu Ala 
            20                  25                  30          


Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu 
        35                  40                  45              


Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln 
    50                  55                  60                  


Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser 
65                  70                  75                  80  


Ser Gln Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro 
                85                  90                  95      


Asp Gln Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu Trp Val Lys 
            100                 105                 110         


Asn Val Phe Leu Asn Gln Thr Arg Thr Gln Arg Val Leu Phe Val Asp 
        115                 120                 125             


Ser Val Gly Leu Pro Ala Pro Pro Ser Ile Ile Lys Ala Met Gly Gly 
    130                 135                 140                 


Ser Gln Pro Gly Glu Leu Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu 
145                 150                 155                 160 


Ile Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro 
                165                 170                 175     


Lys Asn Ser Thr Gly Pro Thr Val Ile Gln Leu Ile Ala Thr Glu Thr 
            180                 185                 190         


Cys Cys Pro Ala Leu Gln Arg Pro His Ser Ala Ser Ala Leu Asp Gln 
        195                 200                 205             


Ser Pro Cys Ala Gln Pro Thr Met Pro Trp Gln Asp Gly Pro Lys Gln 
    210                 215                 220                 


Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser 
225                 230                 235                 240 


Cys Leu Ile Ser Gly Leu Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu 
                245                 250                 255     


Arg Ser Glu Pro Asp Gly Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp 
            260                 265                 270         


Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala Leu Gly 
        275                 280                 285             


Leu Gln Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gln Trp Gln 
    290                 295                 300                 


Gln Gln Asp His Ala Ser Ser Gln Gly Phe Phe Tyr His Ser Arg Ala 
305                 310                 315                 320 


Arg Cys Cys Pro Arg Asp Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu 
                325                 330                 335     


Glu Glu Lys Thr Asn Pro Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys 
            340                 345                 350         


His Phe Lys Ser Arg Asn Asp Ser Ile Ile His Ile Leu Val Glu Val 
        355                 360                 365             


Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser Pro Phe Trp 
    370                 375                 380                 


Ile His Gln Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu 
385                 390                 395                 400 


Ile Ser Ser Gly His Leu Glu Leu Glu Trp Gln His Pro Ser Ser Trp 
                405                 410                 415     


Ala Ala Gln Glu Thr Cys Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His 
            420                 425                 430         


Gln Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr 
        435                 440                 445             


Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg 
    450                 455                 460                 


Leu Asn Gly Pro Thr Tyr Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro 
465                 470                 475                 480 


Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr 
                485                 490                 495     


Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu 
            500                 505                 510         


Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu 
        515                 520                 525             


Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg 
    530                 535                 540                 


Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys 
545                 550                 555                 560 


Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu 
                565                 570                 575     


Arg Thr Pro Leu Pro Leu Cys Ser Ser Gln Ala Gln Met Asp Tyr Arg 
            580                 585                 590         


Arg Leu Gln Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro 
        595                 600                 605             


Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His Ile Ala Asn His 
    610                 615                 620                 


Ser Tyr Leu Pro Leu Ser Tyr Trp Gln Gln Pro 
625                 630                 635 


<210>  65
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 signal peptide

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  66
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myristoylation Motif

<400>  66

Met Gly Ser Ser Lys Ser Lys Pro Lys Asp Pro Ser Gln Arg 
1               5                   10                  


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc epitope tag

<400>  67

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 epitope tag

<400>  68

Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10      


<210>  69
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP(F36V) dimerization domain

<400>  69

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  70
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP(F36V)-FKBP(F36V) dimerization domain

<400>  70

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Val Gln Val Glu 
            100                 105                 110         


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
        115                 120                 125             


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
    130                 135                 140                 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
145                 150                 155                 160 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
                165                 170                 175     


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
            180                 185                 190         


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
        195                 200                 205             


Glu Leu Leu Lys Leu Glu 
    210                 


<210>  71
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP(F36V,L106P) dimerization domain

<400>  71

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Pro 
            100                 105         


<210>  72
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP(F36V,L106P)-FKBP(F36V,L106P) dimerization domain

<400>  72

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Pro Gly Val Gln Val Glu 
            100                 105                 110         


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
        115                 120                 125             


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Lys Lys Val Asp Ser 
    130                 135                 140                 


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
145                 150                 155                 160 


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
                165                 170                 175     


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
            180                 185                 190         


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
        195                 200                 205             


Leu Leu Lys Pro Glu 
    210             


<210>  73
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP(E31G,36V,R71G,K105E)-FKBP(E31G,36V,R71G,K105E) dimerization domain

<400>  73

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Glu Leu Gly Val Gln Val Glu 
            100                 105                 110         


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
        115                 120                 125             


Cys Val Val His Tyr Thr Gly Met Leu Gly Asp Gly Lys Lys Val Asp 
    130                 135                 140                 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
145                 150                 155                 160 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
                165                 170                 175     


Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
            180                 185                 190         


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
        195                 200                 205             


Glu Leu Leu Glu Leu Glu 
    210                 


<210>  74
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALK5/TGFBR1(1-126) dimerization domain

<400>  74

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu 
        115                 120                 125     


<210>  75
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFBR2(1-166) dimerization domain

<400>  75

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln 
                165     


<210>  76
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpoR(1-236) dimerization domain

<400>  76

Met Asp His Leu Gly Ala Ser Leu Trp Pro Gln Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Leu Pro Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Gly Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Asp Glu Pro Trp Lys Leu Cys Arg Leu His Gln Ala 
                85                  90                  95      


Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Ser 
        115                 120                 125             


Gly Ala Pro Arg Tyr His Arg Val Ile His Ile Asn Glu Val Val Leu 
    130                 135                 140                 


Leu Asp Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly 
145                 150                 155                 160 


His Val Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser 
                165                 170                 175     


His Ile Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser 
            180                 185                 190         


Val Gln Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser 
        195                 200                 205             


Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp 
225                 230                 235     


<210>  77
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PrlR(1-220) dimerization domain

<400>  77

Met Lys Glu Asn Val Ala Ser Ala Thr Val Phe Thr Leu Leu Leu Phe 
1               5                   10                  15      


Leu Asn Thr Cys Leu Leu Asn Gly Gln Leu Pro Pro Gly Lys Pro Glu 
            20                  25                  30          


Ile Phe Lys Cys Arg Ser Pro Asn Lys Glu Thr Phe Thr Cys Trp Trp 
        35                  40                  45              


Arg Pro Gly Thr Asp Gly Gly Leu Pro Thr Asn Tyr Ser Leu Thr Tyr 
    50                  55                  60                  


His Arg Glu Gly Glu Thr Leu Met His Glu Cys Pro Asp Tyr Ile Thr 
65                  70                  75                  80  


Gly Gly Pro Asn Ser Cys His Phe Gly Lys Gln Tyr Thr Ser Met Trp 
                85                  90                  95      


Arg Thr Tyr Ile Met Met Val Asn Ala Thr Asn Gln Met Gly Ser Ser 
            100                 105                 110         


Phe Ser Asp Glu Leu Tyr Val Asp Val Thr Tyr Ile Val Gln Pro Asp 
        115                 120                 125             


Pro Pro Leu Glu Leu Ala Val Glu Val Lys Gln Pro Glu Asp Arg Lys 
    130                 135                 140                 


Pro Tyr Leu Trp Ile Lys Trp Ser Pro Pro Thr Leu Ile Asp Leu Lys 
145                 150                 155                 160 


Thr Gly Trp Phe Thr Leu Leu Tyr Glu Ile Arg Leu Lys Pro Glu Lys 
                165                 170                 175     


Ala Ala Glu Trp Glu Ile His Phe Ala Gly Gln Gln Thr Glu Phe Lys 
            180                 185                 190         


Ile Leu Ser Leu His Pro Gly Gln Lys Tyr Leu Val Gln Val Arg Cys 
        195                 200                 205             


Lys Pro Asp His Gly Tyr Trp Ser Ala Trp Ser Pro 
    210                 215                 220 


<210>  78
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHR(1-250) dimerization domain

<400>  78

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Pro Trp Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr 
                245                 250 


<210>  79
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(1-478) dimerization domain

<400>  79

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Gln Asp Val Ser Leu Leu Ala 
            20                  25                  30          


Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu 
        35                  40                  45              


Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln 
    50                  55                  60                  


Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser 
65                  70                  75                  80  


Ser Gln Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro 
                85                  90                  95      


Asp Gln Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu Trp Val Lys 
            100                 105                 110         


Asn Val Phe Leu Asn Gln Thr Arg Thr Gln Arg Val Leu Phe Val Asp 
        115                 120                 125             


Ser Val Gly Leu Pro Ala Pro Pro Ser Ile Ile Lys Ala Met Gly Gly 
    130                 135                 140                 


Ser Gln Pro Gly Glu Leu Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu 
145                 150                 155                 160 


Ile Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro 
                165                 170                 175     


Lys Asn Ser Thr Gly Pro Thr Val Ile Gln Leu Ile Ala Thr Glu Thr 
            180                 185                 190         


Cys Cys Pro Ala Leu Gln Arg Pro His Ser Ala Ser Ala Leu Asp Gln 
        195                 200                 205             


Ser Pro Cys Ala Gln Pro Thr Met Pro Trp Gln Asp Gly Pro Lys Gln 
    210                 215                 220                 


Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser 
225                 230                 235                 240 


Cys Leu Ile Ser Gly Leu Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu 
                245                 250                 255     


Arg Ser Glu Pro Asp Gly Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp 
            260                 265                 270         


Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala Leu Gly 
        275                 280                 285             


Leu Gln Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gln Trp Gln 
    290                 295                 300                 


Gln Gln Asp His Ala Ser Ser Gln Gly Phe Phe Tyr His Ser Arg Ala 
305                 310                 315                 320 


Arg Cys Cys Pro Arg Asp Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu 
                325                 330                 335     


Glu Glu Lys Thr Asn Pro Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys 
            340                 345                 350         


His Phe Lys Ser Arg Asn Asp Ser Ile Ile His Ile Leu Val Glu Val 
        355                 360                 365             


Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser Pro Phe Trp 
    370                 375                 380                 


Ile His Gln Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu 
385                 390                 395                 400 


Ile Ser Ser Gly His Leu Glu Leu Glu Trp Gln His Pro Ser Ser Trp 
                405                 410                 415     


Ala Ala Gln Glu Thr Cys Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His 
            420                 425                 430         


Gln Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr 
        435                 440                 445             


Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg 
    450                 455                 460                 


Leu Asn Gly Pro Thr Tyr Gln Gly Pro Trp Ser Ser Trp 
465                 470                 475         


<210>  80
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(1-631) dimerization domain

<400>  80

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro 
625                 630     


<210>  81
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR1(1-362) dimerization domain

<400>  81

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu 
        355                 360         


<210>  82
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDGFRA(1-514) dimerization domain

<400>  82

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu 
        


<210>  83
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDGFRB(1-518) dimerization domain

<400>  83

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr 
        515             


<210>  84
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA (1-54) dimerization domain

<400>  84

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala 
    50                  


<210>  85
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAFF-R (1-78) dimerization domain

<400>  85

Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu 
65                  70                  75              


<210>  86
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI (1-165) dimerization domain

<400>  86

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser 
                165 


<210>  87
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 (1-214) dimerization domain

<400>  87

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala 
    210                 


<210>  88
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8(138-206) tyrosine kinase activating domain

<400>  88

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  89
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpoR(237-338;L241G,L242P) tyrosine kinase activating domain

<400>  89

Ser Glu Pro Val Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile 
1               5                   10                  15      


Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val 
            20                  25                  30          


Leu Ala Leu Leu Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro 
        35                  40                  45              


Gly Ile Pro Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His 
    50                  55                  60                  


Lys Gly Asn Phe Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp 
65                  70                  75                  80  


Trp Ser Pro Cys Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu 
                85                  90                  95      


Val Leu Ser Glu Arg Cys 
            100         


<210>  90
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpoR(237-338) tyrosine kinase activating domain

<400>  90

Ser Glu Pro Val Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile 
1               5                   10                  15      


Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val Leu Leu Thr Val 
            20                  25                  30          


Leu Ala Leu Leu Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro 
        35                  40                  45              


Gly Ile Pro Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His 
    50                  55                  60                  


Lys Gly Asn Phe Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp 
65                  70                  75                  80  


Trp Ser Pro Cys Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu 
                85                  90                  95      


Val Leu Ser Glu Arg Cys 
            100         


<210>  91
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpoR(237-282;L241G,L242P) tyrosine kinase activating domain

<400>  91

Ser Glu Pro Val Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile 
1               5                   10                  15      


Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val 
            20                  25                  30          


Leu Ala Leu Leu Ser His Arg Arg Ala Leu Lys Gln Lys Ile 
        35                  40                  45      


<210>  92
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GP130(609-700) tyrosine kinase activating domain

<400>  92

Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
1               5                   10                  15      


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
            20                  25                  30          


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
        35                  40                  45              


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
    50                  55                  60                  


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
65                  70                  75                  80  


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp 
                85                  90          


<210>  93
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PrlR(221-319) tyrosine kinase activating domain

<400>  93

Ala Thr Phe Ile Gln Ile Pro Ser Asp Phe Thr Met Asn Asp Thr Thr 
1               5                   10                  15      


Val Trp Ile Ser Val Ala Val Leu Ser Ala Val Ile Cys Leu Ile Ile 
            20                  25                  30          


Val Trp Ala Val Ala Leu Lys Gly Tyr Ser Met Val Thr Cys Ile Phe 
        35                  40                  45              


Pro Pro Val Pro Gly Pro Lys Ile Lys Gly Phe Asp Ala His Leu Leu 
    50                  55                  60                  


Glu Lys Gly Lys Ser Glu Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp 
65                  70                  75                  80  


Phe Pro Pro Thr Ser Asp Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu 
                85                  90                  95      


Val Asp Asp 
            


<210>  94
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHR(251-352) tyrosine kinase activating domain

<400>  94

Leu Pro Gln Met Ser Gln Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro 
1               5                   10                  15      


Trp Leu Leu Ile Ile Ile Phe Gly Ile Phe Gly Leu Thr Val Met Leu 
            20                  25                  30          


Phe Val Phe Leu Phe Ser Lys Gln Gln Arg Ile Lys Met Leu Ile Leu 
        35                  40                  45              


Pro Pro Val Pro Val Pro Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu 
    50                  55                  60                  


Lys Glu Gly Lys Leu Glu Glu Val Asn Thr Ile Leu Ala Ile His Asp 
65                  70                  75                  80  


Ser Tyr Lys Pro Glu Phe His Ser Asp Asp Ser Trp Val Glu Phe Ile 
                85                  90                  95      


Glu Leu Asp Ile Asp Glu 
            100         


<210>  95
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCSFR(614-710) tyrosine kinase activating domain

<400>  95

Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser Glu Leu His Ile Ile 
1               5                   10                  15      


Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys Gly Thr 
            20                  25                  30          


Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser 
        35                  40                  45              


Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile 
    50                  55                  60                  


Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile 
65                  70                  75                  80  


Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp 
                85                  90                  95      


Glu 
    


<210>  96
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(478-582) tyrosine kinase activating domain

<400>  96

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser 
1               5                   10                  15      


Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly 
            20                  25                  30          


Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
        35                  40                  45              


His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln 
    50                  55                  60                  


Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser 
65                  70                  75                  80  


Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys 
                85                  90                  95      


Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105 


<210>  97
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(478-528) tyrosine kinase activating domain

<400>  97

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser 
1               5                   10                  15      


Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly 
            20                  25                  30          


Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
        35                  40                  45              


His Ala Leu 
    50      


<210>  98
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(632-979) tyrosine kinase activating domain

<400>  98

Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
1               5                   10                  15      


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            20                  25                  30          


Ile Gly Leu Phe Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu 
        35                  40                  45              


Arg Arg Leu Leu Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser 
    50                  55                  60                  


Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu 
65                  70                  75                  80  


Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
                85                  90                  95      


Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala 
            100                 105                 110         


Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile 
        115                 120                 125             


Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys 
    130                 135                 140                 


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln 
145                 150                 155                 160 


Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp 
                165                 170                 175     


Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys 
            180                 185                 190         


Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala 
        195                 200                 205             


Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp 
    210                 215                 220                 


Phe Gly Leu Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala 
225                 230                 235                 240 


Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
                245                 250                 255     


His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
            260                 265                 270         


Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro 
        275                 280                 285             


Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln 
    290                 295                 300                 


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
305                 310                 315                 320 


Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu 
                325                 330                 335     


Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu 
            340                 345             


<210>  99
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR1(363-767) tyrosine kinase activating domain

<400>  99

Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile 
1               5                   10                  15      


Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser Val 
            20                  25                  30          


Ile Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His Ser 
        35                  40                  45              


Gln Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln 
    50                  55                  60                  


Val Thr Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu 
65                  70                  75                  80  


Leu Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala 
                85                  90                  95      


Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro 
            100                 105                 110         


Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly 
        115                 120                 125             


Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn 
    130                 135                 140                 


Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu 
145                 150                 155                 160 


Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile 
                165                 170                 175     


Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp 
            180                 185                 190         


Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg 
        195                 200                 205             


Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn 
    210                 215                 220                 


Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser 
225                 230                 235                 240 


Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys 
                245                 250                 255     


Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp 
            260                 265                 270         


Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His 
        275                 280                 285             


Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp 
    290                 295                 300                 


Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp 
305                 310                 315                 320 


Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly 
                325                 330                 335     


Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys 
            340                 345                 350         


Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr 
        355                 360                 365             


Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr 
    370                 375                 380                 


Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser 
385                 390                 395                 400 


Asn Gln Glu Tyr Leu 
                405 


<210>  100
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDGFRA(515-954) tyrosine kinase activating domain

<400>  100

Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala Ala Ala 
1               5                   10                  15      


Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val Leu Val 
            20                  25                  30          


Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg Val Ile 
        35                  40                  45              


Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp Pro Met 
    50                  55                  60                  


Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly Leu Val 
65                  70                  75                  80  


Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val Glu Gly 
                85                  90                  95      


Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val Ala Val 
            100                 105                 110         


Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala Leu Met 
        115                 120                 125             


Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn Ile Val 
    130                 135                 140                 


Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile Ile Thr 
145                 150                 155                 160 


Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys Asn Arg 
                165                 170                 175     


Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu Leu Asp 
            180                 185                 190         


Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr Val Ile 
        195                 200                 205             


Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln Ala Asp 
    210                 215                 220                 


Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser Lys Tyr 
225                 230                 235                 240 


Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr Lys Lys 
                245                 250                 255     


Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp Asp Asn 
            260                 265                 270         


Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr Gln Val 
        275                 280                 285             


Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His Arg Asp 
    290                 295                 300                 


Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val Lys Ile 
305                 310                 315                 320 


Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn Tyr Val 
                325                 330                 335     


Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro Glu Ser 
            340                 345                 350         


Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser Tyr Gly 
        355                 360                 365             


Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr Pro Gly 
    370                 375                 380                 


Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly Tyr Arg 
385                 390                 395                 400 


Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile Met Val 
                405                 410                 415     


Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr His Leu 
            420                 425                 430         


Ser Glu Ile Val Glu Asn Leu Leu 
        435                 440 


<210>  101
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDGFRB(519-962) tyrosine kinase activating domain

<400>  101

Gln Glu Val Ile Val Val Pro His Ser Leu Pro Phe Lys Val Val Val 
1               5                   10                  15      


Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser Leu Ile 
            20                  25                  30          


Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg Tyr Glu Ile Arg Trp 
        35                  40                  45              


Lys Val Ile Glu Ser Val Ser Ser Asp Gly His Glu Tyr Ile Tyr Val 
    50                  55                  60                  


Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr Trp Glu Leu Pro Arg Asp 
65                  70                  75                  80  


Gln Leu Val Leu Gly Arg Thr Leu Gly Ser Gly Ala Phe Gly Gln Val 
                85                  90                  95      


Val Glu Ala Thr Ala His Gly Leu Ser His Ser Gln Ala Thr Met Lys 
            100                 105                 110         


Val Ala Val Lys Met Leu Lys Ser Thr Ala Arg Ser Ser Glu Lys Gln 
        115                 120                 125             


Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu Gly Pro His Leu 
    130                 135                 140                 


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Gly Gly Pro Ile Tyr 
145                 150                 155                 160 


Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp Leu Val Asp Tyr Leu His 
                165                 170                 175     


Arg Asn Lys His Thr Phe Leu Gln His His Ser Asp Lys Arg Arg Pro 
            180                 185                 190         


Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu Pro Val Gly Leu Pro Leu 
        195                 200                 205             


Pro Ser His Val Ser Leu Thr Gly Glu Ser Asp Gly Gly Tyr Met Asp 
    210                 215                 220                 


Met Ser Lys Asp Glu Ser Val Asp Tyr Val Pro Met Leu Asp Met Lys 
225                 230                 235                 240 


Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser Ser Asn Tyr Met Ala Pro 
                245                 250                 255     


Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu Arg Thr Cys Arg Ala Thr 
            260                 265                 270         


Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr Met Asp Leu Val Gly Phe 
        275                 280                 285             


Ser Tyr Gln Val Ala Asn Gly Met Glu Phe Leu Ala Ser Lys Asn Cys 
    290                 295                 300                 


Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Ile Cys Glu Gly Lys 
305                 310                 315                 320 


Leu Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met Arg Asp 
                325                 330                 335     


Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe Leu Pro Leu Lys Trp Met 
            340                 345                 350         


Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr Thr Thr Leu Ser Asp Val 
        355                 360                 365             


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Thr 
    370                 375                 380                 


Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln Phe Tyr Asn Ala Ile Lys 
385                 390                 395                 400 


Arg Gly Tyr Arg Met Ala Gln Pro Ala His Ala Ser Asp Glu Ile Tyr 
                405                 410                 415     


Glu Ile Met Gln Lys Cys Trp Glu Glu Lys Phe Glu Ile Arg Pro Pro 
            420                 425                 430         


Phe Ser Gln Leu Val Leu Leu Leu Glu Arg Leu Leu 
        435                 440                 


<210>  102
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine EpoR(236-337;L264G,L265P) tyrosine kinase activating domain

<400>  102

Ser Glu Pro Ala Ser Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile 
1               5                   10                  15      


Leu Thr Leu Ser Leu Ile Leu Val Leu Ile Ser Leu Gly Pro Thr Val 
            20                  25                  30          


Leu Ala Leu Leu Ser His Arg Arg Thr Leu Gln Gln Lys Ile Trp Pro 
        35                  40                  45              


Gly Ile Pro Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His 
    50                  55                  60                  


Lys Gly Asn Phe Gln Leu Trp Leu Leu Gln Arg Asp Gly Cys Leu Trp 
65                  70                  75                  80  


Trp Ser Pro Gly Ser Ser Phe Pro Glu Asp Pro Pro Ala His Leu Glu 
                85                  90                  95      


Val Leu Ser Glu Pro Arg 
            100         


<210>  103
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpoR(273-508) tyrosine kinase activating domain

<400>  103

Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
1               5                   10                  15      


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
            20                  25                  30          


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
        35                  40                  45              


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
    50                  55                  60                  


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
65                  70                  75                  80  


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
                85                  90                  95      


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
            100                 105                 110         


Leu Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
        115                 120                 125             


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
    130                 135                 140                 


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
145                 150                 155                 160 


Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr 
                165                 170                 175     


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
            180                 185                 190         


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
        195                 200                 205             


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
    210                 215                 220                 


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
225                 230                 235     


<210>  104
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1(156-191)-TPOR/MPLR (514-582) TpoR tyrosine kinase activating domain 
       with transmembrane domain variant

<400>  104

Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val 
1               5                   10                  15      


Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val 
            20                  25                  30          


Leu Ala Val Ile Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
        35                  40                  45              


His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln 
    50                  55                  60                  


Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser 
65                  70                  75                  80  


Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys 
                85                  90                  95      


Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105 


<210>  105
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(478-582) (wildtype sequence) TpoR tyrosine kinase activating domain 
       with transmembrane domain variant

<400>  105

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser 
1               5                   10                  15      


Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly 
            20                  25                  30          


Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
        35                  40                  45              


His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln 
    50                  55                  60                  


Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser 
65                  70                  75                  80  


Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys 
                85                  90                  95      


Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105 


<210>  106
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-1) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  106

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Trp Ile Ser Leu 
1               5                   10                  15      


Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu 
            20                  25                  30          


Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His 
        35                  40                  45              


Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr 
    50                  55                  60                  


Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp 
65                  70                  75                  80  


Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser 
                85                  90                  95      


Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 


<210>  107
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-2) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  107

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ile Ser Leu Val 
1               5                   10                  15      


Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu 
            20                  25                  30          


Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala 
        35                  40                  45              


Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu 
    50                  55                  60                  


Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr 
65                  70                  75                  80  


Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser 
                85                  90                  95      


Glu Arg Thr Pro Leu Pro Leu 
            100             


<210>  108
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-2+1) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  108

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Ile Ser Leu 
1               5                   10                  15      


Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu 
            20                  25                  30          


Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His 
        35                  40                  45              


Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr 
    50                  55                  60                  


Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp 
65                  70                  75                  80  


Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser 
                85                  90                  95      


Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 


<210>  109
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-3) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  109

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ser Leu Val Thr 
1               5                   10                  15      


Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu 
            20                  25                  30          


Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu 
        35                  40                  45              


Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg 
    50                  55                  60                  


Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys 
65                  70                  75                  80  


Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu 
                85                  90                  95      


Arg Thr Pro Leu Pro Leu 
            100         


<210>  110
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-4) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  110

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Val Thr Ala 
1               5                   10                  15      


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
            20                  25                  30          


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
        35                  40                  45              


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
    50                  55                  60                  


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
65                  70                  75                  80  


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
                85                  90                  95      


Thr Pro Leu Pro Leu 
            100     


<210>  111
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-4+1) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  111

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ile Leu Val Thr 
1               5                   10                  15      


Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu 
            20                  25                  30          


Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu 
        35                  40                  45              


Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg 
    50                  55                  60                  


Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys 
65                  70                  75                  80  


Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu 
                85                  90                  95      


Arg Thr Pro Leu Pro Leu 
            100         


<210>  112
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-5) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  112

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Val Thr Ala Leu 
1               5                   10                  15      


His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg 
            20                  25                  30          


Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro 
        35                  40                  45              


Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr 
    50                  55                  60                  


Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu 
65                  70                  75                  80  


Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr 
                85                  90                  95      


Pro Leu Pro Leu 
            100 


<210>  113
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-6) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  113

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Thr Ala Leu His 
1               5                   10                  15      


Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp 
            20                  25                  30          


Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser 
        35                  40                  45              


Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala 
    50                  55                  60                  


Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val 
65                  70                  75                  80  


Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro 
                85                  90                  95      


Leu Pro Leu 
            


<210>  114
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-7) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  114

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Leu His Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln 
            20                  25                  30          


Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu 
        35                  40                  45              


Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala 
    50                  55                  60                  


Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu 
65                  70                  75                  80  


Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu 
                85                  90                  95      


Pro Leu 
        


<210>  115
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-8) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  115

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu His Leu Val 
1               5                   10                  15      


Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe 
            20                  25                  30          


Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro 
        35                  40                  45              


Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu 
    50                  55                  60                  


Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro 
65                  70                  75                  80  


Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro 
                85                  90                  95      


Leu 
    


<210>  116
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-9) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  116

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr His Leu Val Leu 
1               5                   10                  15      


Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro 
            20                  25                  30          


Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp 
        35                  40                  45              


Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser 
    50                  55                  60                  


Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser 
65                  70                  75                  80  


Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
                85                  90                  95      


<210>  117
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-10) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  117

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Val Leu Gly 
1               5                   10                  15      


Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala 
            20                  25                  30          


His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu 
        35                  40                  45              


His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro 
    50                  55                  60                  


Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu 
65                  70                  75                  80  


Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
                85                  90                  95  


<210>  118
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-11) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  118

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Val Leu Gly Leu 
1               5                   10                  15      


Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His 
            20                  25                  30          


Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His 
        35                  40                  45              


Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro 
    50                  55                  60                  


Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
                85                  90                  


<210>  119
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-12) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  119

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Gly Leu Ser 
1               5                   10                  15      


Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr 
            20                  25                  30          


Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg 
        35                  40                  45              


Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys 
    50                  55                  60                  


Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu 
65                  70                  75                  80  


Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
                85                  90              


<210>  120
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-13) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  120

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Gly Leu Ser Ala 
1               5                   10                  15      


Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg 
            20                  25                  30          


Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val 
        35                  40                  45              


Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala 
    50                  55                  60                  


Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile 
65                  70                  75                  80  


Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
                85                  90          


<210>  121
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-14) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  121

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Ser Ala Val 
1               5                   10                  15      


Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg 
            20                  25                  30          


Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu 
        35                  40                  45              


Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr 
    50                  55                  60                  


Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu 
65                  70                  75                  80  


Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
                85                  90      


<210>  122
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-15) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  122

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ser Ala Val Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
            20                  25                  30          


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
        35                  40                  45              


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
    50                  55                  60                  


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
65                  70                  75                  80  


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
                85                  90  


<210>  123
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-16) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  123

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Val Leu Gly 
1               5                   10                  15      


Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
            20                  25                  30          


His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln 
        35                  40                  45              


Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser 
    50                  55                  60                  


Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys 
65                  70                  75                  80  


Ser Ser Glu Arg Thr Pro Leu Pro Leu 
                85                  


<210>  124
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-17) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  124

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Val Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His 
            20                  25                  30          


Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr 
        35                  40                  45              


Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp 
    50                  55                  60                  


Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser 
65                  70                  75                  80  


Ser Glu Arg Thr Pro Leu Pro Leu 
                85              


<210>  125
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N-18) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  125

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Gly Leu Leu 
1               5                   10                  15      


Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala 
            20                  25                  30          


Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu 
        35                  40                  45              


Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr 
    50                  55                  60                  


Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser 
65                  70                  75                  80  


Glu Arg Thr Pro Leu Pro Leu 
                85          


<210>  126
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N+1) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  126

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Ile 
1               5                   10                  15      


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
            20                  25                  30          


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
        35                  40                  45              


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
    50                  55                  60                  


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
65                  70                  75                  80  


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
                85                  90                  95      


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105     


<210>  127
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N+2) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  127

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Val Leu 
1               5                   10                  15      


Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val 
            20                  25                  30          


Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg 
        35                  40                  45              


Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu 
    50                  55                  60                  


Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr 
65                  70                  75                  80  


Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu 
                85                  90                  95      


Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105         


<210>  128
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N+3) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  128

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Val 
1               5                   10                  15      


Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala 
            20                  25                  30          


Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg 
        35                  40                  45              


Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val 
    50                  55                  60                  


Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala 
65                  70                  75                  80  


Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile 
                85                  90                  95      


Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105             


<210>  129
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N+4) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  129

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Leu 
1               5                   10                  15      


Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser 
            20                  25                  30          


Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr 
        35                  40                  45              


Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg 
    50                  55                  60                  


Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys 
65                  70                  75                  80  


Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu 
                85                  90                  95      


Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105                 


<210>  130
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N+5) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  130

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Ile 
1               5                   10                  15      


Leu Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu 
            20                  25                  30          


Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His 
        35                  40                  45              


Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His 
    50                  55                  60                  


Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro 
65                  70                  75                  80  


Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu 
                85                  90                  95      


Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105                 110 


<210>  131
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N+6) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  131

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Leu 
1               5                   10                  15      


Ile Leu Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly 
            20                  25                  30          


Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala 
        35                  40                  45              


His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu 
    50                  55                  60                  


His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro 
65                  70                  75                  80  


Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu 
                85                  90                  95      


Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105                 110     


<210>  132
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N+7) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  132

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Val Leu 
1               5                   10                  15      


Leu Ile Leu Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu 
            20                  25                  30          


Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro 
        35                  40                  45              


Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp 
    50                  55                  60                  


Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser 
65                  70                  75                  80  


Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser 
                85                  90                  95      


Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
            100                 105                 110         


<210>  133
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPOR/MPLR(N+8) TpoR tyrosine kinase activating domain with transmembrane domain 
       variant

<400>  133

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Val 
1               5                   10                  15      


Leu Leu Ile Leu Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val 
            20                  25                  30          


Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe 
        35                  40                  45              


Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro 
    50                  55                  60                  


Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu 
65                  70                  75                  80  


Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro 
                85                  90                  95      


Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro 
            100                 105                 110         


Leu 
    


<210>  134
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R(316-459) tyrosine kinase effector domains

<400>  134

Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
1               5                   10                  15      


Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro 
            20                  25                  30          


Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg 
        35                  40                  45              


Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala 
    50                  55                  60                  


Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys 
65                  70                  75                  80  


Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr 
                85                  90                  95      


Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr 
            100                 105                 110         


Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser 
        115                 120                 125             


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    130                 135                 140                 


<210>  135
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2Rb(333-551) tyrosine kinase effector domains

<400>  135

Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser 
1               5                   10                  15      


Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr 
            20                  25                  30          


Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val 
        35                  40                  45              


Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val 
    50                  55                  60                  


Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser 
65                  70                  75                  80  


Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu 
                85                  90                  95      


Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala 
            100                 105                 110         


Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln 
        115                 120                 125             


Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr 
    130                 135                 140                 


Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val 
145                 150                 155                 160 


Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly 
                165                 170                 175     


Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala 
            180                 185                 190         


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
        195                 200                 205             


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    210                 215                 


<210>  136
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNAR1(508-557) tyrosine kinase effector domains

<400>  136

Ile Ser Thr Ile Ala Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp 
1               5                   10                  15      


His Lys Lys Tyr Ser Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser 
            20                  25                  30          


Asn Glu Asp Glu Ser Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp 
        35                  40                  45              


Phe Val 
    50  


<210>  137
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNAR2(310-515) tyrosine kinase effector domains

<400>  137

Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp Glu Ser Asp Ser Asp 
1               5                   10                  15      


Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly Tyr Thr Met His Gly 
            20                  25                  30          


Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala Thr Ser Thr Glu Ser 
        35                  40                  45              


Gln Leu Ile Asp Pro Glu Ser Glu Glu Glu Pro Asp Leu Pro Glu Val 
    50                  55                  60                  


Asp Val Glu Leu Pro Thr Met Pro Lys Asp Ser Pro Gln Gln Leu Glu 
65                  70                  75                  80  


Leu Leu Ser Gly Pro Cys Glu Arg Arg Lys Ser Pro Leu Gln Asp Pro 
                85                  90                  95      


Phe Pro Glu Glu Asp Tyr Ser Ser Thr Glu Gly Ser Gly Gly Arg Ile 
            100                 105                 110         


Thr Phe Asn Val Asp Leu Asn Ser Val Phe Leu Arg Val Leu Asp Asp 
        115                 120                 125             


Glu Asp Ser Asp Asp Leu Glu Ala Pro Leu Met Leu Ser Ser His Leu 
    130                 135                 140                 


Glu Glu Met Val Asp Pro Glu Asp Pro Asp Asn Val Gln Ser Asn His 
145                 150                 155                 160 


Leu Leu Ala Ser Gly Glu Gly Thr Gln Pro Thr Phe Pro Ser Pro Ser 
                165                 170                 175     


Ser Glu Gly Leu Trp Ser Glu Asp Ala Pro Ser Asp Gln Ser Asp Thr 
            180                 185                 190         


Ser Glu Ser Asp Val Asp Leu Gly Asp Gly Tyr Ile Met Arg 
        195                 200                 205     


<210>  138
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNAR1/2(IFNAR1 residues 508-557-IFNAR2 residues 310-515) tyrosine 
       kinase effector domains

<400>  138

Ile Ser Thr Ile Ala Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp 
1               5                   10                  15      


His Lys Lys Tyr Ser Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser 
            20                  25                  30          


Asn Glu Asp Glu Ser Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp 
        35                  40                  45              


Phe Val Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp Glu Ser Asp 
    50                  55                  60                  


Ser Asp Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly Tyr Thr Met 
65                  70                  75                  80  


His Gly Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala Thr Ser Thr 
                85                  90                  95      


Glu Ser Gln Leu Ile Asp Pro Glu Ser Glu Glu Glu Pro Asp Leu Pro 
            100                 105                 110         


Glu Val Asp Val Glu Leu Pro Thr Met Pro Lys Asp Ser Pro Gln Gln 
        115                 120                 125             


Leu Glu Leu Leu Ser Gly Pro Cys Glu Arg Arg Lys Ser Pro Leu Gln 
    130                 135                 140                 


Asp Pro Phe Pro Glu Glu Asp Tyr Ser Ser Thr Glu Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Ile Thr Phe Asn Val Asp Leu Asn Ser Val Phe Leu Arg Val Leu 
                165                 170                 175     


Asp Asp Glu Asp Ser Asp Asp Leu Glu Ala Pro Leu Met Leu Ser Ser 
            180                 185                 190         


His Leu Glu Glu Met Val Asp Pro Glu Asp Pro Asp Asn Val Gln Ser 
        195                 200                 205             


Asn His Leu Leu Ala Ser Gly Glu Gly Thr Gln Pro Thr Phe Pro Ser 
    210                 215                 220                 


Pro Ser Ser Glu Gly Leu Trp Ser Glu Asp Ala Pro Ser Asp Gln Ser 
225                 230                 235                 240 


Asp Thr Ser Glu Ser Asp Val Asp Leu Gly Asp Gly Tyr Ile Met Arg 
                245                 250                 255     


<210>  139
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNLR1(300-520) tyrosine kinase effector domains

<400>  139

Arg Gly Val Arg Pro Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln 
1               5                   10                  15      


Thr Arg Trp Lys Lys Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu 
            20                  25                  30          


Glu Asp Thr Glu Asp Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro 
        35                  40                  45              


Ser Phe Leu Gly Gln Glu His Gln Ala Pro Gly His Ser Glu Ala Gly 
    50                  55                  60                  


Gly Val Asp Ser Gly Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly 
65                  70                  75                  80  


Ser Ser Ala Trp Asp Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp 
                85                  90                  95      


Ser Ser Trp Asp Arg Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly 
            100                 105                 110         


Pro Gly Gln Gly Pro Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro 
        115                 120                 125             


Pro Glu Phe Ser Lys Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp 
    130                 135                 140                 


Asn Leu Ser Ser Trp Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn 
145                 150                 155                 160 


Leu Val Pro Gly Gly Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys 
                165                 170                 175     


Trp Glu Ser Ser Pro Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile 
            180                 185                 190         


Glu Asp Ser Asp Ala Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr 
        195                 200                 205             


Glu Asp Arg Gly Arg Thr Leu Gly His Tyr Met Ala Arg 
    210                 215                 220     


<210>  140
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Common Gamma Chain(335-369) tyrosine kinase effector domains

<400>  140

Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro 
1               5                   10                  15      


Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys 
            20                  25                  30          


Pro Glu Thr 
        35  


<210>  141
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL9R(356-521) tyrosine kinase effector domains

<400>  141

Thr Ala Leu Leu Thr Cys Gly Pro Ala Arg Pro Trp Lys Ser Val Ala 
1               5                   10                  15      


Leu Glu Glu Glu Gln Glu Gly Pro Gly Thr Arg Leu Pro Gly Asn Leu 
            20                  25                  30          


Ser Ser Glu Asp Val Leu Pro Ala Gly Cys Thr Glu Trp Arg Val Gln 
        35                  40                  45              


Thr Leu Ala Tyr Leu Pro Gln Glu Asp Trp Ala Pro Thr Ser Leu Thr 
    50                  55                  60                  


Arg Pro Ala Pro Pro Asp Ser Glu Gly Ser Arg Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Asn Asn Asn Asn Tyr Cys Ala Leu Gly Cys Tyr Gly Gly 
                85                  90                  95      


Trp His Leu Ser Ala Leu Pro Gly Asn Thr Gln Ser Ser Gly Pro Ile 
            100                 105                 110         


Pro Ala Leu Ala Cys Gly Leu Ser Cys Asp His Gln Gly Leu Glu Thr 
        115                 120                 125             


Gln Gln Gly Val Ala Trp Val Leu Ala Gly His Cys Gln Arg Pro Gly 
    130                 135                 140                 


Leu His Glu Asp Leu Gln Gly Met Leu Leu Pro Ser Val Leu Ser Lys 
145                 150                 155                 160 


Ala Arg Ser Trp Thr Phe 
                165     


<210>  142
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL21R(322-538) tyrosine kinase effector domains

<400>  142

Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro 
1               5                   10                  15      


Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp Pro 
            20                  25                  30          


Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg 
        35                  40                  45              


Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu 
    50                  55                  60                  


Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala 
65                  70                  75                  80  


Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro 
                85                  90                  95      


Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala 
            100                 105                 110         


Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu 
        115                 120                 125             


Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp 
    130                 135                 140                 


Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro 
145                 150                 155                 160 


Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser 
                165                 170                 175     


Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu 
            180                 185                 190         


Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro 
        195                 200                 205             


Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    210                 215         


<210>  143
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHR(353-638) tyrosine kinase effector domains

<400>  143

Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
1               5                   10                  15      


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
            20                  25                  30          


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
        35                  40                  45              


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
    50                  55                  60                  


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
65                  70                  75                  80  


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
                85                  90                  95      


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
            100                 105                 110         


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
        115                 120                 125             


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
    130                 135                 140                 


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
145                 150                 155                 160 


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
                165                 170                 175     


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
            180                 185                 190         


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
        195                 200                 205             


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
    210                 215                 220                 


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
225                 230                 235                 240 


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
                245                 250                 255     


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
            260                 265                 270         


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
        275                 280                 285     


<210>  144
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpoR(339-508) tyrosine kinase effector domains

<400>  144

Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly Pro 
1               5                   10                  15      


Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu Val 
            20                  25                  30          


Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu Pro 
        35                  40                  45              


Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser Glu 
    50                  55                  60                  


Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu Gly 
65                  70                  75                  80  


Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser Gln 
                85                  90                  95      


Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro Pro 
            100                 105                 110         


His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile Ser Thr 
        115                 120                 125             


Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser Asp 
    130                 135                 140                 


Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala Glu 
145                 150                 155                 160 


Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
                165                 170 


<210>  145
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine IL2Rb(337-539) tyrosine kinase effector domains

<400>  145

Ala Val Gln Leu Leu Leu Leu Gln Lys Asp Ser Ala Pro Leu Pro Ser 
1               5                   10                  15      


Pro Ser Gly His Ser Gln Ala Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
            20                  25                  30          


Phe Phe His Leu Pro Asn Ala Leu Glu Ile Glu Ser Cys Gln Val Tyr 
        35                  40                  45              


Phe Thr Tyr Asp Pro Cys Val Glu Glu Glu Val Glu Glu Asp Gly Ser 
    50                  55                  60                  


Arg Leu Pro Glu Gly Ser Pro His Pro Pro Leu Leu Pro Leu Ala Gly 
65                  70                  75                  80  


Glu Gln Asp Asp Tyr Cys Ala Phe Pro Pro Arg Asp Asp Leu Leu Leu 
                85                  90                  95      


Phe Ser Pro Ser Leu Ser Thr Pro Asn Thr Ala Tyr Gly Gly Ser Arg 
            100                 105                 110         


Ala Pro Glu Glu Arg Ser Pro Leu Ser Leu His Glu Gly Leu Pro Ser 
        115                 120                 125             


Leu Ala Ser Arg Asp Leu Met Gly Leu Gln Arg Pro Leu Glu Arg Met 
    130                 135                 140                 


Pro Glu Gly Asp Gly Glu Gly Leu Ser Ala Asn Ser Ser Gly Glu Gln 
145                 150                 155                 160 


Ala Ser Val Pro Glu Gly Asn Leu His Gly Gln Asp Gln Asp Arg Gly 
                165                 170                 175     


Gln Gly Pro Ile Leu Thr Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
            180                 185                 190         


Glu Leu Gln Ala Gln Asp Ser Val His Leu Ile 
        195                 200             


<210>  146
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine IL7Ra(316-459) tyrosine kinase effector domains

<400>  146

Ala Arg Asp Glu Val Glu Ser Phe Leu Pro Asn Asp Leu Pro Ala Gln 
1               5                   10                  15      


Pro Glu Glu Leu Glu Thr Gln Gly His Arg Ala Ala Val His Ser Ala 
            20                  25                  30          


Asn Arg Ser Pro Glu Thr Ser Val Ser Pro Pro Glu Thr Val Arg Arg 
        35                  40                  45              


Glu Ser Pro Leu Arg Cys Leu Ala Arg Asn Leu Ser Thr Cys Asn Ala 
    50                  55                  60                  


Pro Pro Leu Leu Ser Ser Arg Ser Pro Asp Tyr Arg Asp Gly Asp Arg 
65                  70                  75                  80  


Asn Arg Pro Pro Val Tyr Gln Asp Leu Leu Pro Asn Ser Gly Asn Thr 
                85                  90                  95      


Asn Val Pro Val Pro Val Pro Gln Pro Leu Pro Phe Gln Ser Gly Ile 
            100                 105                 110         


Leu Ile Pro Val Ser Gln Arg Gln Pro Ile Ser Thr Ser Ser Val Leu 
        115                 120                 125             


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Lys 
    130                 135                 140                 


<210>  147
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(955-1186) tyrosine kinase effector domains

<400>  147

Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser 
1               5                   10                  15      


Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val 
            20                  25                  30          


Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser Pro 
        35                  40                  45              


Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala Thr Ser Asn 
    50                  55                  60                  


Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln Ser Cys Pro 
65                  70                  75                  80  


Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp Pro Thr Gly 
                85                  90                  95      


Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro Val Pro Glu 
            100                 105                 110         


Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser Val Gln Asn 
        115                 120                 125             


Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser Arg Asp Pro 
    130                 135                 140                 


His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro Glu Tyr Leu 
145                 150                 155                 160 


Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp Ser Pro Ala 
                165                 170                 175     


His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro Asp 
            180                 185                 190         


Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile Phe 
        195                 200                 205             


Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln 
    210                 215                 220                 


Ser Ser Glu Phe Ile Gly Ala 
225                 230     


<210>  148
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(955-1186;Y974F,d1045-1057) tyrosine kinase effector domains

<400>  148

Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser 
1               5                   10                  15      


Asn Phe Phe Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val 
            20                  25                  30          


Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser Pro 
        35                  40                  45              


Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala Thr Ser Asn 
    50                  55                  60                  


Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln Ser Cys Pro 
65                  70                  75                  80  


Ile Lys Glu Asp Ser Phe Leu Gln Arg Ile Asp Asp Thr Phe Leu Pro 
                85                  90                  95      


Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser 
            100                 105                 110         


Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser 
        115                 120                 125             


Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro 
    130                 135                 140                 


Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp 
145                 150                 155                 160 


Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp 
                165                 170                 175     


Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn 
            180                 185                 190         


Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val 
        195                 200                 205             


Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
    210                 215             


<210>  149
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(955-1009;Y974F) tyrosine kinase effector domains

<400>  149

Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser 
1               5                   10                  15      


Asn Phe Phe Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val 
            20                  25                  30          


Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser Pro 
        35                  40                  45              


Ser Thr Ser Arg Thr Pro 
    50                  


<210>  150
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(1019-1085) tyrosine kinase effector domains

<400>  150

Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln Ser Cys 
1               5                   10                  15      


Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Ile Asp Asp Thr Phe Leu 
            20                  25                  30          


Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly 
        35                  40                  45              


Ser Val Gln Asn Pro Val 
    50                  


<210>  151
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(1037-1103;Y1068/1101F,d1045-1057) tyrosine kinase effector domains

<400>  151

Lys Glu Asp Ser Phe Leu Gln Arg Ile Asp Asp Thr Phe Leu Pro Val 
1               5                   10                  15      


Pro Glu Phe Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser Val 
            20                  25                  30          


Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser Arg 
        35                  40                  45              


Asp Pro His Phe Gln Asp 
    50                  


<210>  152
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(1066-1118;Y1068/1086F) tyrosine kinase effector domains

<400>  152

Val Pro Glu Phe Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser 
1               5                   10                  15      


Val Gln Asn Pro Val Phe His Asn Gln Pro Leu Asn Pro Ala Pro Ser 
            20                  25                  30          


Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro 
        35                  40                  45              


Glu Tyr Leu Asn Thr Val 
    50                  


<210>  153
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(1122-1165) tyrosine kinase effector domains

<400>  153

Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe 
1               5                   10                  15      


Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu 
            20                  25                  30          


Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro 
        35                  40                  45              


Asn Gly Ile Phe Lys Gly 
    50                  


<210>  154
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR(1133-1186;Y1148F) tyrosine kinase effector domains

<400>  154

Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro Asp Phe 
1               5                   10                  15      


Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile Phe Lys 
            20                  25                  30          


Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln Ser 
        35                  40                  45              


Ser Glu Phe Ile Gly Ala 
    50                  


<210>  155
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12Rb2(775-825) tyrosine kinase effector domains

<400>  155

Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro 
1               5                   10                  15      


Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
            20                  25                  30          


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
        35                  40                  45              


Glu Pro Gln 
    50      


<210>  156
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R(376-416) tyrosine kinase effector domains

<400>  156

Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg 
1               5                   10                  15      


Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser 
            20                  25                  30          


Leu Gly Thr Thr Asn Ser Thr Leu Pro 
        35                  40      


<210>  157
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R(424-459) tyrosine kinase effector domains

<400>  157

Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr 
1               5                   10                  15      


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
            20                  25                  30          


Tyr Gln Asn Gln 
        35      


<210>  158
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R(376-416,424-459) tyrosine kinase effector domains

<400>  158

Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg 
1               5                   10                  15      


Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser 
            20                  25                  30          


Leu Gly Thr Thr Asn Ser Thr Leu Pro Gln Gly Gln Pro Ile Leu Thr 
        35                  40                  45              


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
    50                  55                  60                  


Tyr Gln Asn Gln 
65              


<210>  159
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R(424-459;Y456F) tyrosine kinase effector domains

<400>  159

Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr 
1               5                   10                  15      


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
            20                  25                  30          


Phe Gln Asn Gln 
        35      


<210>  160
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R(376-416,424-459,Y456F) tyrosine kinase effector domains

<400>  160

Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg 
1               5                   10                  15      


Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser 
            20                  25                  30          


Leu Gly Thr Thr Asn Ser Thr Leu Pro Gln Gly Gln Pro Ile Leu Thr 
        35                  40                  45              


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
    50                  55                  60                  


Phe Gln Asn Gln 
65              


<210>  161
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2small(393-433) tyrosine kinase effector domains

<400>  161

Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu 
1               5                   10                  15      


Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg 
            20                  25                  30          


Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala 
        35                  40                  45              


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
    50                  55                  60                  


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
65                  70                  75  


<210>  162
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2small(518-551) tyrosine kinase effector domains

<400>  162

Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr 
1               5                   10                  15      


Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His 
            20                  25                  30          


Leu Val 
        


<210>  163
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2small(339-379,393-433) tyrosine kinase effector domains

<400>  163

Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser 
1               5                   10                  15      


Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro 
            20                  25                  30          


Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu Gly Val Ala Gly Ala 
        35                  40                  45              


Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp 
    50                  55                  60                  


Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser 
65                  70                  75                  80  


Pro Ser 
        


<210>  164
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2small(339-379,518-551) tyrosine kinase effector domains

<400>  164

Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser 
1               5                   10                  15      


Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro 
            20                  25                  30          


Asp Ala Leu Glu Ile Glu Ala Cys Gln Gly Gln Gly Glu Phe Arg Ala 
        35                  40                  45              


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
    50                  55                  60                  


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
65                  70                  75  


<210>  165
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2small(393-433,518-551) tyrosine kinase effector domains

<400>  165

Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu 
1               5                   10                  15      


Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg 
            20                  25                  30          


Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala 
        35                  40                  45              


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
    50                  55                  60                  


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
65                  70                  75  


<210>  166
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2small(339-379,393-433,518-551) tyrosine kinase effector domains

<400>  166

Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser 
1               5                   10                  15      


Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro 
            20                  25                  30          


Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu Gly Val Ala Gly Ala 
        35                  40                  45              


Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp 
    50                  55                  60                  


Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser 
65                  70                  75                  80  


Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu 
                85                  90                  95      


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
            100                 105                 110         


Thr His Leu Val 
        115     


<210>  167
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNAR2small(310-352) tyrosine kinase effector domains

<400>  167

Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp Glu Ser Asp Ser Asp 
1               5                   10                  15      


Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly Tyr Thr Met His Gly 
            20                  25                  30          


Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala 
        35                  40              


<210>  168
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNAR2small(486-515) tyrosine kinase effector domains

<400>  168

Glu Gly Leu Trp Ser Glu Asp Ala Pro Ser Asp Gln Ser Asp Thr Ser 
1               5                   10                  15      


Glu Ser Asp Val Asp Leu Gly Asp Gly Tyr Ile Met Arg 
            20                  25                  


<210>  169
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNAR2small(310-352,486-515) tyrosine kinase effector domains

<400>  169

Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp Glu Ser Asp Ser Asp 
1               5                   10                  15      


Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly Tyr Thr Met His Gly 
            20                  25                  30          


Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala Glu Gly Leu Trp Ser 
        35                  40                  45              


Glu Asp Ala Pro Ser Asp Gln Ser Asp Thr Ser Glu Ser Asp Val Asp 
    50                  55                  60                  


Leu Gly Asp Gly Tyr Ile Met Arg 
65                  70          


<210>  170
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLNK(53-208) tyrosine kinase effector domains

<400>  170

Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp Asp Phe 
1               5                   10                  15      


Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp Ser Glu Met Tyr 
            20                  25                  30          


Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr Glu Pro Pro Pro 
        35                  40                  45              


Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe Ala Arg 
    50                  55                  60                  


Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro Pro Phe 
65                  70                  75                  80  


Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys Ala Arg 
                85                  90                  95      


Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro Gln Val 
            100                 105                 110         


Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr Val Val 
        115                 120                 125             


Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu Ser Ser 
    130                 135                 140                 


Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
145                 150                 155     


<210>  171
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLNK(53-208;Y72F) tyrosine kinase effector domains

<400>  171

Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp Asp Phe 
1               5                   10                  15      


Asp Ser Asp Phe Glu Asn Pro Asp Glu His Ser Asp Ser Glu Met Tyr 
            20                  25                  30          


Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr Glu Pro Pro Pro 
        35                  40                  45              


Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe Ala Arg 
    50                  55                  60                  


Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro Pro Phe 
65                  70                  75                  80  


Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys Ala Arg 
                85                  90                  95      


Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro Gln Val 
            100                 105                 110         


Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr Val Val 
        115                 120                 125             


Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu Ser Ser 
    130                 135                 140                 


Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
145                 150                 155     


<210>  172
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLNK(53-208;Y72F,Y96F) tyrosine kinase effector domains

<400>  172

Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp Asp Phe 
1               5                   10                  15      


Asp Ser Asp Phe Glu Asn Pro Asp Glu His Ser Asp Ser Glu Met Tyr 
            20                  25                  30          


Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Phe Glu Pro Pro Pro 
        35                  40                  45              


Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe Ala Arg 
    50                  55                  60                  


Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro Pro Phe 
65                  70                  75                  80  


Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys Ala Arg 
                85                  90                  95      


Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro Gln Val 
            100                 105                 110         


Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr Val Val 
        115                 120                 125             


Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu Ser Ser 
    130                 135                 140                 


Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
145                 150                 155     


<210>  173
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpoR(339-508) tyrosine kinase effector domains

<400>  173

Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly Pro 
1               5                   10                  15      


Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu Val 
            20                  25                  30          


Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu Pro 
        35                  40                  45              


Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser Glu 
    50                  55                  60                  


Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu Gly 
65                  70                  75                  80  


Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser Gln 
                85                  90                  95      


Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro Pro 
            100                 105                 110         


His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile Ser Thr 
        115                 120                 125             


Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser Asp 
    130                 135                 140                 


Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala Glu 
145                 150                 155                 160 


Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
                165                 170 


<210>  174
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12Rb2(714-862) tyrosine kinase effector domains

<400>  174

Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp Pro Gln Arg 
1               5                   10                  15      


Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp Met Met His 
            20                  25                  30          


Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala Glu Ser Arg 
        35                  40                  45              


Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly Ser Asp Pro 
    50                  55                  60                  


Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp 
65                  70                  75                  80  


Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro 
                85                  90                  95      


Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            100                 105                 110         


His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His Pro Leu Thr 
        115                 120                 125             


Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys Met Arg Cys 
    130                 135                 140                 


Asp Ser Leu Met Leu 
145                 


<210>  175
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12Rb1(622-662) tyrosine kinase effector domains

<400>  175

Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro 
1               5                   10                  15      


Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp 
            20                  25                  30          


Gly Asp Arg Cys Lys Ala Lys Met 
        35                  40  


<210>  176
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL10R1(304-578) tyrosine kinase effector domains

<400>  176

Val Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly Ser Thr Asp Ser 
1               5                   10                  15      


Gly Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu Glu Pro Gln Phe 
            20                  25                  30          


Leu Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr Leu Gly Asn Arg 
        35                  40                  45              


Glu Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly Ser Ser Asn Ser 
    50                  55                  60                  


Thr Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu Ser Pro Ser Thr 
65                  70                  75                  80  


Gly Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser Arg Gly Gln Asp 
                85                  90                  95      


Asp Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly Arg Ala Gly Asp 
            100                 105                 110         


Thr Gln Gly Gly Ser Ala Leu Gly His His Ser Pro Pro Glu Pro Glu 
        115                 120                 125             


Val Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe Gln Gly Tyr Leu 
    130                 135                 140                 


Arg Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys Thr Gly Cys Leu 
145                 150                 155                 160 


Glu Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro Lys Phe Gly Arg 
                165                 170                 175     


Cys Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala Leu Ala Lys Gly 
            180                 185                 190         


Tyr Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala Ser Ser Gly Ala 
        195                 200                 205             


Pro Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp Ser Leu Leu Ala 
    210                 215                 220                 


Leu Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp Ser Phe Ala His 
225                 230                 235                 240 


Asp Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly Gly Leu Leu Gly 
                245                 250                 255     


Ser Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile Ser Ser Leu Gln 
            260                 265                 270         


Ser Ser Glu 
        275 


<210>  177
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myristoyl-Myd88-CD40-FKBP(F36V)x2 (GoCART) construct

<400>  177

Met Gly Ser Ser Lys Ser Lys Pro Lys Asp Pro Ser Gln Arg Met Ala 
1               5                   10                  15      


Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser 
            20                  25                  30          


Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser 
        35                  40                  45              


Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu 
    50                  55                  60                  


Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr 
65                  70                  75                  80  


Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro 
                85                  90                  95      


Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg 
            100                 105                 110         


Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln 
        115                 120                 125             


Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln 
    130                 135                 140                 


Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly 
145                 150                 155                 160 


Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg Phe Asp 
                165                 170                 175     


Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Lys Lys Val Ala Lys Lys 
            180                 185                 190         


Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn 
        195                 200                 205             


Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu 
    210                 215                 220                 


Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser 
225                 230                 235                 240 


Arg Ile Ser Val Gln Glu Arg Gln Gly Val Gln Val Glu Thr Ile Ser 
                245                 250                 255     


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
            260                 265                 270         


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg 
        275                 280                 285             


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
    290                 295                 300                 


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
305                 310                 315                 320 


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
                325                 330                 335     


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
            340                 345                 350         


Lys Leu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
        355                 360                 365             


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
    370                 375                 380                 


Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
385                 390                 395                 400 


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
                405                 410                 415     


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
            420                 425                 430         


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
        435                 440                 445             


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    450                 455                 460     


<210>  178
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TagBFP construct

<400>  178

Met Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Lys Leu Asn 
225                 230             


<210>  179
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 epitope tag

<400>  179

Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10              


<210>  180
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2173 scFv domain

<400>  180

Glu Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Phe Asn Ile Glu Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asn Asp Glu Thr Lys Tyr Gly Pro Ile Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Thr Ser Ile Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Arg Gly Gly Val Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Asp Ser 
    130                 135                 140                 


Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser 
145                 150                 155                 160 


Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Pro Pro Lys Arg Leu Ile Ser Leu Val Ser Lys 
            180                 185                 190         


Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gly Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  181
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26C8 scFv domain

<400>  181

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Asn Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Val Thr Ala Ala Asp Ala Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Phe His Trp Gly Phe Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Arg Val Ser Asn Thr Tyr Leu Ala Trp Tyr Gln Gln Asn Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Gly Thr Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  182
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge and transmembrane domain

<400>  182

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  183
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular signaling domain

<400>  183

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  184
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3z intracellular signaling domain

<400>  184

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  185
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BFP domain

<400>  185

Met Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Lys Leu Asn 
225                 230             


<210>  186
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A domain

<400>  186

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  187
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582)-IL7R(316-459)-IL12Rb2(775-825)

<400>  187

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
145                 150                 155                 160 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
                165                 170                 175     


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
            180                 185                 190         


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
        195                 200                 205             


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
    210                 215                 220                 


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
225                 230                 235                 240 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
                245                 250                 255     


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
            260                 265                 270         


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
        275                 280                 285             


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
    290                 295                 300                 


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
305                 310                 315                 320 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
                325                 330                 335     


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
            340                 345                 350         


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
        355                 360                 365             


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu 
    370                 375                 380                 


Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr 
385                 390                 395                 400 


His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu 
                405                 410                 415     


Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425                 


<210>  188
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-1)-IL7R(316-459)-IL12Rb2(775-825)

<400>  188

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Trp Ile Ser 
    130                 135                 140                 


Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly 
145                 150                 155                 160 


Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
                165                 170                 175     


His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln 
            180                 185                 190         


Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser 
        195                 200                 205             


Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys 
    210                 215                 220                 


Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly 
225                 230                 235                 240 


Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln 
                245                 250                 255     


Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val 
            260                 265                 270         


Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu 
        275                 280                 285             


Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg 
    290                 295                 300                 


Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln 
305                 310                 315                 320 


Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro 
                325                 330                 335     


Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly 
            340                 345                 350         


Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val 
        355                 360                 365             


Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn 
    370                 375                 380                 


Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His 
385                 390                 395                 400 


Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala 
                405                 410                 415     


Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425             


<210>  189
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-2)-IL7R(316-459)-IL12Rb2(775-825)

<400>  189

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ile Ser Leu 
    130                 135                 140                 


Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu 
145                 150                 155                 160 


Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His 
                165                 170                 175     


Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr 
            180                 185                 190         


Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp 
        195                 200                 205             


Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser 
    210                 215                 220                 


Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe 
225                 230                 235                 240 


Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg 
                245                 250                 255     


Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val 
            260                 265                 270         


Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala 
        275                 280                 285             


Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser 
    290                 295                 300                 


Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe 
                325                 330                 335     


Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln 
            340                 345                 350         


Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr 
        355                 360                 365             


Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro 
    370                 375                 380                 


Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp 
385                 390                 395                 400 


Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro 
                405                 410                 415     


Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425         


<210>  190
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-2+1)-IL7R(316-459)-IL12Rb2(775-825)

<400>  190

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Ile Ser 
    130                 135                 140                 


Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly 
145                 150                 155                 160 


Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
                165                 170                 175     


His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln 
            180                 185                 190         


Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser 
        195                 200                 205             


Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys 
    210                 215                 220                 


Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly 
225                 230                 235                 240 


Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln 
                245                 250                 255     


Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val 
            260                 265                 270         


Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu 
        275                 280                 285             


Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg 
    290                 295                 300                 


Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln 
305                 310                 315                 320 


Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro 
                325                 330                 335     


Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly 
            340                 345                 350         


Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val 
        355                 360                 365             


Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn 
    370                 375                 380                 


Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His 
385                 390                 395                 400 


Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala 
                405                 410                 415     


Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425             


<210>  191
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-3)-IL7R(316-459)-IL12Rb2(775-825)

<400>  191

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ser Leu Val 
    130                 135                 140                 


Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu 
145                 150                 155                 160 


Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala 
                165                 170                 175     


Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu 
            180                 185                 190         


Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr 
        195                 200                 205             


Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser 
    210                 215                 220                 


Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu 
225                 230                 235                 240 


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
                245                 250                 255     


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
            260                 265                 270         


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
        275                 280                 285             


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
    290                 295                 300                 


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
                325                 330                 335     


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
            340                 345                 350         


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
        355                 360                 365             


Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala 
    370                 375                 380                 


Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly 
385                 390                 395                 400 


Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu 
                405                 410                 415     


Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425     


<210>  192
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-4)-IL7R(316-459)-IL12Rb2(775-825)

<400>  192

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Val Thr 
    130                 135                 140                 


Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu 
145                 150                 155                 160 


Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu 
                165                 170                 175     


Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg 
            180                 185                 190         


Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys 
        195                 200                 205             


Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu 
    210                 215                 220                 


Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln 
225                 230                 235                 240 


Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly 
                245                 250                 255     


Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr 
            260                 265                 270         


Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn 
        275                 280                 285             


Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
    290                 295                 300                 


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu 
                325                 330                 335     


Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile 
            340                 345                 350         


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
        355                 360                 365             


Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
    370                 375                 380                 


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
385                 390                 395                 400 


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
                405                 410                 415     


Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425 


<210>  193
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-4+1)-IL7R(316-459)-IL12Rb2(775-825)

<400>  193

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ile Leu Val 
    130                 135                 140                 


Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu 
145                 150                 155                 160 


Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala 
                165                 170                 175     


Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu 
            180                 185                 190         


Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr 
        195                 200                 205             


Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser 
    210                 215                 220                 


Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu 
225                 230                 235                 240 


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
                245                 250                 255     


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
            260                 265                 270         


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
        275                 280                 285             


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
    290                 295                 300                 


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
                325                 330                 335     


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
            340                 345                 350         


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
        355                 360                 365             


Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala 
    370                 375                 380                 


Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly 
385                 390                 395                 400 


Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu 
                405                 410                 415     


Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425     


<210>  194
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-5)-IL7R(316-459)-IL12Rb2(775-825)

<400>  194

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Val Thr Ala 
    130                 135                 140                 


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
145                 150                 155                 160 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
                165                 170                 175     


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
            180                 185                 190         


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
        195                 200                 205             


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
    210                 215                 220                 


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
225                 230                 235                 240 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
                245                 250                 255     


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
            260                 265                 270         


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
        275                 280                 285             


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
    290                 295                 300                 


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
                325                 330                 335     


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
            340                 345                 350         


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
        355                 360                 365             


Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro 
    370                 375                 380                 


Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu 
385                 390                 395                 400 


Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp 
                405                 410                 415     


Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 


<210>  195
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-6)-IL7R(316-459)-IL12Rb2(775-825)

<400>  195

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Thr Ala Leu 
    130                 135                 140                 


His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg 
145                 150                 155                 160 


Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro 
                165                 170                 175     


Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr 
            180                 185                 190         


Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu 
        195                 200                 205             


Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr 
    210                 215                 220                 


Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr 
225                 230                 235                 240 


Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp 
                245                 250                 255     


Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu 
            260                 265                 270         


Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser 
        275                 280                 285             


Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg 
    290                 295                 300                 


Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser 
                325                 330                 335     


Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr 
            340                 345                 350         


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
        355                 360                 365             


Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp 
    370                 375                 380                 


Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro 
385                 390                 395                 400 


Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser 
                405                 410                 415     


Leu Glu Glu Leu Glu Pro Gln 
            420             


<210>  196
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-7)-IL7R(316-459)-IL12Rb2(775-825)

<400>  196

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Leu His 
    130                 135                 140                 


Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp 
145                 150                 155                 160 


Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser 
                165                 170                 175     


Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala 
            180                 185                 190         


Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val 
        195                 200                 205             


Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro 
    210                 215                 220                 


Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
225                 230                 235                 240 


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
                245                 250                 255     


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
            260                 265                 270         


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
        275                 280                 285             


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
    290                 295                 300                 


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
305                 310                 315                 320 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
                325                 330                 335     


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
            340                 345                 350         


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
        355                 360                 365             


Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr 
    370                 375                 380                 


Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser 
385                 390                 395                 400 


Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu 
                405                 410                 415     


Glu Glu Leu Glu Pro Gln 
            420         


<210>  197
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-8)-IL7R(316-459)-IL12Rb2(775-825)

<400>  197

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu His Leu 
    130                 135                 140                 


Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln 
145                 150                 155                 160 


Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu 
                165                 170                 175     


Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala 
            180                 185                 190         


Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu 
        195                 200                 205             


Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu 
    210                 215                 220                 


Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
225                 230                 235                 240 


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
                245                 250                 255     


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe 
            260                 265                 270         


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
        275                 280                 285             


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
    290                 295                 300                 


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
305                 310                 315                 320 


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
                325                 330                 335     


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
            340                 345                 350         


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
        355                 360                 365             


Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val 
    370                 375                 380                 


Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn 
385                 390                 395                 400 


Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu 
                405                 410                 415     


Glu Leu Glu Pro Gln 
            420     


<210>  198
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-9)-IL7R(316-459)-IL12Rb2(775-825)

<400>  198

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr His Leu Val 
    130                 135                 140                 


Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe 
145                 150                 155                 160 


Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro 
                165                 170                 175     


Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu 
            180                 185                 190         


Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro 
        195                 200                 205             


Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro 
    210                 215                 220                 


Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln 
225                 230                 235                 240 


Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser 
                245                 250                 255     


Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly 
            260                 265                 270         


Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp 
        275                 280                 285             


Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly 
    290                 295                 300                 


Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr 
305                 310                 315                 320 


Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu 
                325                 330                 335     


Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly 
            340                 345                 350         


Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
        355                 360                 365             


Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu 
    370                 375                 380                 


Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile 
385                 390                 395                 400 


Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu 
                405                 410                 415     


Leu Glu Pro Gln 
            420 


<210>  199
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-10)-IL7R(316-459)-IL12Rb2(775-825)

<400>  199

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Val Leu 
    130                 135                 140                 


Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro 
145                 150                 155                 160 


Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp 
                165                 170                 175     


Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser 
            180                 185                 190         


Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser 
        195                 200                 205             


Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
    210                 215                 220                 


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
225                 230                 235                 240 


Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro 
                245                 250                 255     


Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg 
            260                 265                 270         


Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala 
        275                 280                 285             


Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys 
    290                 295                 300                 


Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr 
305                 310                 315                 320 


Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr 
                325                 330                 335     


Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser 
            340                 345                 350         


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
        355                 360                 365             


Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro 
    370                 375                 380                 


Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
385                 390                 395                 400 


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
                405                 410                 415     


Glu Pro Gln 
            


<210>  200
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-11)-IL7R(316-459)-IL12Rb2(775-825)

<400>  200

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Val Leu Gly 
    130                 135                 140                 


Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala 
145                 150                 155                 160 


His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu 
                165                 170                 175     


His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro 
            180                 185                 190         


Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu 
        195                 200                 205             


Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala 
    210                 215                 220                 


Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu 
225                 230                 235                 240 


Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn 
                245                 250                 255     


Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp 
            260                 265                 270         


Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro 
        275                 280                 285             


Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn 
    290                 295                 300                 


Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn 
305                 310                 315                 320 


Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu 
                325                 330                 335     


Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn 
            340                 345                 350         


Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser 
        355                 360                 365             


Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala 
    370                 375                 380                 


Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp 
385                 390                 395                 400 


Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu 
                405                 410                 415     


Pro Gln 
        


<210>  201
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-12)-IL7R(316-459)-IL12Rb2(775-825)

<400>  201

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Gly Leu 
    130                 135                 140                 


Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His 
145                 150                 155                 160 


Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His 
                165                 170                 175     


Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro 
            180                 185                 190         


Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu 
        195                 200                 205             


Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg 
    210                 215                 220                 


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
225                 230                 235                 240 


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
                245                 250                 255     


Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser 
            260                 265                 270         


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
        275                 280                 285             


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
    290                 295                 300                 


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
305                 310                 315                 320 


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
                325                 330                 335     


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
            340                 345                 350         


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp 
        355                 360                 365             


Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly 
    370                 375                 380                 


Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu 
385                 390                 395                 400 


Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro 
                405                 410                 415     


Gln 
    


<210>  202
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-13)-IL7R(316-459)-IL12Rb2(775-825)

<400>  202

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Gly Leu Ser 
    130                 135                 140                 


Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr 
145                 150                 155                 160 


Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg 
                165                 170                 175     


Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys 
            180                 185                 190         


Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu 
        195                 200                 205             


Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp 
    210                 215                 220                 


Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu 
225                 230                 235                 240 


Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro 
                245                 250                 255     


Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser 
            260                 265                 270         


Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu 
        275                 280                 285             


Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
    290                 295                 300                 


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
305                 310                 315                 320 


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
                325                 330                 335     


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
            340                 345                 350         


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro 
        355                 360                 365             


Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp 
    370                 375                 380                 


Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro 
385                 390                 395                 400 


Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410                 415     


<210>  203
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-14)-IL7R(316-459)-IL12Rb2(775-825)

<400>  203

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Ser Ala 
    130                 135                 140                 


Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg 
145                 150                 155                 160 


Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val 
                165                 170                 175     


Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala 
            180                 185                 190         


Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile 
        195                 200                 205             


Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu 
    210                 215                 220                 


Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser 
225                 230                 235                 240 


Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser 
                245                 250                 255     


Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu 
            260                 265                 270         


Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser 
        275                 280                 285             


Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His 
    290                 295                 300                 


Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu 
305                 310                 315                 320 


Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val 
                325                 330                 335     


Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu 
            340                 345                 350         


Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys 
        355                 360                 365             


Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu 
    370                 375                 380                 


Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser 
385                 390                 395                 400 


His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410                 415 


<210>  204
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-15)-IL7R(316-459)-IL12Rb2(775-825)

<400>  204

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ser Ala Val 
    130                 135                 140                 


Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg 
145                 150                 155                 160 


Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu 
                165                 170                 175     


Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr 
            180                 185                 190         


Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu 
        195                 200                 205             


Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val 
    210                 215                 220                 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
225                 230                 235                 240 


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
                245                 250                 255     


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
            260                 265                 270         


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
        275                 280                 285             


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
    290                 295                 300                 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
305                 310                 315                 320 


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
                325                 330                 335     


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
            340                 345                 350         


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro 
        355                 360                 365             


Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro 
    370                 375                 380                 


Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His 
385                 390                 395                 400 


Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410                 


<210>  205
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-16)-IL7R(316-459)-IL12Rb2(775-825)

<400>  205

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Val Leu 
    130                 135                 140                 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
145                 150                 155                 160 


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
                165                 170                 175     


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
            180                 185                 190         


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
        195                 200                 205             


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
    210                 215                 220                 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
225                 230                 235                 240 


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
                245                 250                 255     


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
            260                 265                 270         


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
        275                 280                 285             


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
    290                 295                 300                 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
305                 310                 315                 320 


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
                325                 330                 335     


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
            340                 345                 350         


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu 
        355                 360                 365             


Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr 
    370                 375                 380                 


His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu 
385                 390                 395                 400 


Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410             


<210>  206
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-17)-IL7R(316-459)-IL12Rb2(775-825)

<400>  206

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Val Leu Gly 
    130                 135                 140                 


Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
145                 150                 155                 160 


His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln 
                165                 170                 175     


Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser 
            180                 185                 190         


Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys 
        195                 200                 205             


Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly 
    210                 215                 220                 


Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln 
225                 230                 235                 240 


Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val 
                245                 250                 255     


Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu 
            260                 265                 270         


Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg 
        275                 280                 285             


Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln 
    290                 295                 300                 


Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro 
305                 310                 315                 320 


Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly 
                325                 330                 335     


Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val 
            340                 345                 350         


Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn 
        355                 360                 365             


Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His 
    370                 375                 380                 


Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala 
385                 390                 395                 400 


Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410         


<210>  207
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N-18)-IL7R(316-459)-IL12Rb2(775-825)

<400>  207

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Leu Gly Leu 
    130                 135                 140                 


Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His 
145                 150                 155                 160 


Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr 
                165                 170                 175     


Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp 
            180                 185                 190         


Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser 
        195                 200                 205             


Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe 
    210                 215                 220                 


Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg 
225                 230                 235                 240 


Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val 
                245                 250                 255     


Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala 
            260                 265                 270         


Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser 
        275                 280                 285             


Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp 
    290                 295                 300                 


Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe 
305                 310                 315                 320 


Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln 
                325                 330                 335     


Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr 
            340                 345                 350         


Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro 
        355                 360                 365             


Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp 
    370                 375                 380                 


Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro 
385                 390                 395                 400 


Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410     


<210>  208
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N+1)-IL7R(316-459)-IL12Rb2(775-825)

<400>  208

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu 
    130                 135                 140                 


Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val 
145                 150                 155                 160 


Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg 
                165                 170                 175     


Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu 
            180                 185                 190         


Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr 
        195                 200                 205             


Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu 
    210                 215                 220                 


Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val 
225                 230                 235                 240 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                245                 250                 255     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            260                 265                 270         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        275                 280                 285             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    290                 295                 300                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
305                 310                 315                 320 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                325                 330                 335     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            340                 345                 350         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        355                 360                 365             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro 
    370                 375                 380                 


Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro 
385                 390                 395                 400 


Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His 
                405                 410                 415     


Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425                 430 


<210>  209
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N+2)-IL7R(316-459)-IL12Rb2(775-825)

<400>  209

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Val 
    130                 135                 140                 


Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala 
145                 150                 155                 160 


Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg 
                165                 170                 175     


Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val 
            180                 185                 190         


Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala 
        195                 200                 205             


Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile 
    210                 215                 220                 


Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu 
225                 230                 235                 240 


Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser 
                245                 250                 255     


Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser 
            260                 265                 270         


Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu 
        275                 280                 285             


Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser 
    290                 295                 300                 


Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His 
305                 310                 315                 320 


Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu 
                325                 330                 335     


Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val 
            340                 345                 350         


Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu 
        355                 360                 365             


Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys 
    370                 375                 380                 


Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu 
385                 390                 395                 400 


Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser 
                405                 410                 415     


His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425                 430     


<210>  210
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N+3)-IL7R(316-459)-IL12Rb2(775-825)

<400>  210

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu 
    130                 135                 140                 


Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser 
145                 150                 155                 160 


Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr 
                165                 170                 175     


Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg 
            180                 185                 190         


Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys 
        195                 200                 205             


Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu 
    210                 215                 220                 


Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp 
225                 230                 235                 240 


Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu 
                245                 250                 255     


Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro 
            260                 265                 270         


Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser 
        275                 280                 285             


Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu 
    290                 295                 300                 


Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
305                 310                 315                 320 


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
                325                 330                 335     


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
            340                 345                 350         


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
        355                 360                 365             


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro 
    370                 375                 380                 


Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp 
385                 390                 395                 400 


Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro 
                405                 410                 415     


Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
            420                 425                 430         


<210>  211
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N+4)-IL7R(316-459)-IL12Rb2(775-825)

<400>  211

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile 
    130                 135                 140                 


Leu Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu 
145                 150                 155                 160 


Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His 
                165                 170                 175     


Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His 
            180                 185                 190         


Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro 
        195                 200                 205             


Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu 
    210                 215                 220                 


Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg 
225                 230                 235                 240 


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
                245                 250                 255     


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
            260                 265                 270         


Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser 
        275                 280                 285             


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
    290                 295                 300                 


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
305                 310                 315                 320 


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
                325                 330                 335     


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
            340                 345                 350         


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
        355                 360                 365             


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp 
    370                 375                 380                 


Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly 
385                 390                 395                 400 


Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu 
                405                 410                 415     


Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro 
            420                 425                 430         


Gln 
    


<210>  212
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N+5)-IL7R(316-459)-IL12Rb2(775-825)

<400>  212

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu 
    130                 135                 140                 


Ile Leu Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly 
145                 150                 155                 160 


Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala 
                165                 170                 175     


His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu 
            180                 185                 190         


His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro 
        195                 200                 205             


Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu 
    210                 215                 220                 


Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala 
225                 230                 235                 240 


Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu 
                245                 250                 255     


Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn 
            260                 265                 270         


Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp 
        275                 280                 285             


Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro 
    290                 295                 300                 


Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn 
305                 310                 315                 320 


Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn 
                325                 330                 335     


Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu 
            340                 345                 350         


Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn 
        355                 360                 365             


Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser 
    370                 375                 380                 


Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala 
385                 390                 395                 400 


Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp 
                405                 410                 415     


Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu 
            420                 425                 430         


Pro Gln 
        


<210>  213
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N+6)-IL7R(316-459)-IL12Rb2(775-825)

<400>  213

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu 
    130                 135                 140                 


Leu Ile Leu Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu 
145                 150                 155                 160 


Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro 
                165                 170                 175     


Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp 
            180                 185                 190         


Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser 
        195                 200                 205             


Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser 
    210                 215                 220                 


Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
225                 230                 235                 240 


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
                245                 250                 255     


Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro 
            260                 265                 270         


Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg 
        275                 280                 285             


Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala 
    290                 295                 300                 


Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys 
305                 310                 315                 320 


Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr 
                325                 330                 335     


Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr 
            340                 345                 350         


Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser 
        355                 360                 365             


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    370                 375                 380                 


Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro 
385                 390                 395                 400 


Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
                405                 410                 415     


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
            420                 425                 430         


Glu Pro Gln 
        435 


<210>  214
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N+7)-IL7R(316-459)-IL12Rb2(775-825)

<400>  214

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Val 
    130                 135                 140                 


Leu Leu Ile Leu Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val 
145                 150                 155                 160 


Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe 
                165                 170                 175     


Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro 
            180                 185                 190         


Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu 
        195                 200                 205             


Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro 
    210                 215                 220                 


Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro 
225                 230                 235                 240 


Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln 
                245                 250                 255     


Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser 
            260                 265                 270         


Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly 
        275                 280                 285             


Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp 
    290                 295                 300                 


Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly 
305                 310                 315                 320 


Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr 
                325                 330                 335     


Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu 
            340                 345                 350         


Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly 
        355                 360                 365             


Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
    370                 375                 380                 


Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu 
385                 390                 395                 400 


Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile 
                405                 410                 415     


Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu 
            420                 425                 430         


Leu Glu Pro Gln 
        435     


<210>  215
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8 SS-FKBP(F36V)-TPOR/MPLR(478-582;N+7)-IL7R(316-459)-IL12Rb2(775-825)

<400>  215

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
            20                  25                  30          


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
        35                  40                  45              


Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg 
    50                  55                  60                  


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
65                  70                  75                  80  


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
                85                  90                  95      


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
            100                 105                 110         


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
        115                 120                 125             


Glu Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu 
    130                 135                 140                 


Val Leu Leu Ile Leu Val Leu Ile Ser Leu Val Thr Ala Leu His Leu 
145                 150                 155                 160 


Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln 
                165                 170                 175     


Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu 
            180                 185                 190         


Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala 
        195                 200                 205             


Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu 
    210                 215                 220                 


Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu 
225                 230                 235                 240 


Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
                245                 250                 255     


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
            260                 265                 270         


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe 
        275                 280                 285             


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
    290                 295                 300                 


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
305                 310                 315                 320 


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
                325                 330                 335     


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
            340                 345                 350         


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
        355                 360                 365             


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
    370                 375                 380                 


Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val 
385                 390                 395                 400 


Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn 
                405                 410                 415     


Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu 
            420                 425                 430         


Glu Leu Glu Pro Gln 
        435         


<210>  216
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization domain

<400>  216

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn 
    50              


<210>  217
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization domain

<400>  217

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val 
                165                 170 


<210>  218
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dimerization domain

<400>  218

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser 
            100                 105             


<210>  219
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary tyrosine kinase activating domain

<400>  219

Ser Glu Pro Val Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile 
1               5                   10                  15      


Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val Leu Leu Thr Val 
            20                  25                  30          


Leu Ala Leu Leu Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro 
        35                  40                  45              


Gly Ile Pro Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His 
    50                  55                  60                  


Lys Gly Asn Phe Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp 
65                  70                  75                  80  


Trp Ser Pro Cys Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu 
                85                  90                  95      


Val Leu Ser Glu Arg Cys 
            100         


<210>  220
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary tyrosine kinase activating domain

<400>  220

Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
1               5                   10                  15      


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            20                  25                  30          


Ile Gly Leu Phe Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu 
        35                  40                  45              


Arg Arg Leu Leu Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser 
    50                  55                  60                  


Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu 
65                  70                  75                  80  


Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
                85                  90                  95      


Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala 
            100                 105                 110         


Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile 
        115                 120                 125             


Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys 
    130                 135                 140                 


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln 
145                 150                 155                 160 


Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp 
                165                 170                 175     


Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys 
            180                 185                 190         


Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala 
        195                 200                 205             


Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp 
    210                 215                 220                 


Phe Gly Leu Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala 
225                 230                 235                 240 


Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
                245                 250                 255     


His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
            260                 265                 270         


Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro 
        275                 280                 285             


Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln 
    290                 295                 300                 


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
305                 310                 315                 320 


Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu 
                325                 330                 335     


Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu 
            340                 345             


<210>  221
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary tyrosine effector domain

<400>  221

Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser 
1               5                   10                  15      


Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr 
            20                  25                  30          


Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val 
        35                  40                  45              


Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val 
    50                  55                  60                  


Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser 
65                  70                  75                  80  


Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu 
                85                  90                  95      


Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala 
            100                 105                 110         


Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln 
        115                 120                 125             


Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr 
    130                 135                 140                 


Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val 
145                 150                 155                 160 


Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly 
                165                 170                 175     


Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala 
            180                 185                 190         


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
        195                 200                 205             


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    210                 215                 


<210>  222
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary tyrosine effector domain

<400>  222

Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser 
1               5                   10                  15      


Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val 
            20                  25                  30          


Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser Pro 
        35                  40                  45              


Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala Thr Ser Asn 
    50                  55                  60                  


Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln Ser Cys Pro 
65                  70                  75                  80  


Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp Pro Thr Gly 
                85                  90                  95      


Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro Val Pro Glu 
            100                 105                 110         


Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser Val Gln Asn 
        115                 120                 125             


Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser Arg Asp Pro 
    130                 135                 140                 


His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro Glu Tyr Leu 
145                 150                 155                 160 


Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp Ser Pro Ala 
                165                 170                 175     


His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro Asp 
            180                 185                 190         


Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile Phe 
        195                 200                 205             


Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln 
    210                 215                 220                 


Ser Ser Glu Phe Ile Gly Ala 
225                 230     


<210>  223
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary tyrosine effector domain

<400>  223

Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp Asp Phe 
1               5                   10                  15      


Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp Ser Glu Met Tyr 
            20                  25                  30          


Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr Glu Pro Pro Pro 
        35                  40                  45              


Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe Ala Arg 
    50                  55                  60                  


Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro Pro Phe 
65                  70                  75                  80  


Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys Ala Arg 
                85                  90                  95      


Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro Gln Val 
            100                 105                 110         


Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr Val Val 
        115                 120                 125             


Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu Ser Ser 
    130                 135                 140                 


Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
145                 150                 155     


<210>  224
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  224

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15


<210>  225
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)-EpoR(237-508;L241G,L242P)

<400>  225

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
    210                 215                 220                 


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
225                 230                 235                 240 


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
                245                 250                 255     


Leu Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
            260                 265                 270         


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
        275                 280                 285             


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
    290                 295                 300                 


Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr 
305                 310                 315                 320 


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
                325                 330                 335     


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
            340                 345                 350         


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
        355                 360                 365             


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
    370                 375                 380 


<210>  226
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  EpoR(273-508)-FKBP(F36V)-FKBP(F36V)

<400>  226

Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
1               5                   10                  15      


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
            20                  25                  30          


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
        35                  40                  45              


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
    50                  55                  60                  


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
65                  70                  75                  80  


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
                85                  90                  95      


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
            100                 105                 110         


Leu Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
        115                 120                 125             


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
    130                 135                 140                 


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
145                 150                 155                 160 


Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr 
                165                 170                 175     


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
            180                 185                 190         


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
        195                 200                 205             


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
    210                 215                 220                 


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser Met Gly Val Gln 
225                 230                 235                 240 


Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly 
                245                 250                 255     


Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys 
            260                 265                 270         


Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly 
        275                 280                 285             


Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser 
    290                 295                 300                 


Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly 
305                 310                 315                 320 


Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
                325                 330                 335     


Asp Val Glu Leu Leu Lys Leu Gly Val Gln Val Glu Thr Ile Ser Pro 
            340                 345                 350         


Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His 
        355                 360                 365             


Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp 
    370                 375                 380                 


Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg 
385                 390                 395                 400 


Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys 
                405                 410                 415     


Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly 
            420                 425                 430         


Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys 
        435                 440                 445             


Leu Glu 
    450 


<210>  227
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  EpoR(273-508)-FKBP(E31G,36V,R71G,K105E)-FKBP(E31G,36V,R71G,K105E)

<400>  227

Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
1               5                   10                  15      


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
            20                  25                  30          


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
        35                  40                  45              


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
    50                  55                  60                  


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
65                  70                  75                  80  


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
                85                  90                  95      


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
            100                 105                 110         


Leu Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
        115                 120                 125             


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
    130                 135                 140                 


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
145                 150                 155                 160 


Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr 
                165                 170                 175     


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
            180                 185                 190         


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
        195                 200                 205             


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
    210                 215                 220                 


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser Met Gly Val Gln 
225                 230                 235                 240 


Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly 
                245                 250                 255     


Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly Asp Gly Lys Lys 
            260                 265                 270         


Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly 
        275                 280                 285             


Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser 
    290                 295                 300                 


Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly 
305                 310                 315                 320 


Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
                325                 330                 335     


Asp Val Glu Leu Leu Glu Leu Gly Val Gln Val Glu Thr Ile Ser Pro 
            340                 345                 350         


Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His 
        355                 360                 365             


Tyr Thr Gly Met Leu Gly Asp Gly Lys Lys Val Asp Ser Ser Arg Asp 
    370                 375                 380                 


Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg 
385                 390                 395                 400 


Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Gly Ala Lys 
                405                 410                 415     


Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly 
            420                 425                 430         


Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Glu 
        435                 440                 445             


Leu Glu 
    450 


<210>  228
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-EpoR(237-338;L241G,L242P)-GHR(353-638)

<400>  228

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu 
    210                 215                 220                 


Ser Ser Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly 
225                 230                 235                 240 


Asp Ser Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp 
                245                 250                 255     


Phe Asn Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro 
            260                 265                 270         


Gln Arg Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn 
        275                 280                 285             


Gln Asn Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro 
    290                 295                 300                 


Ser Val Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu 
305                 310                 315                 320 


Gly Ala Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro 
                325                 330                 335     


Ser Ser Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr 
            340                 345                 350         


Pro Ala Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly 
        355                 360                 365             


Met Ser Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu 
    370                 375                 380                 


Asn Phe Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys 
385                 390                 395                 400 


Cys Ile Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro 
                405                 410                 415     


Ser Leu Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr 
            420                 425                 430         


Ala Ala Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met 
        435                 440                 445             


Pro Val Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly 
    450                 455                 460                 


Leu Ile Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu 
465                 470                 475                 480 


Ser Ser Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
                485                 490                 495     


<210>  229
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL2Rb(333-551)

<400>  229

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro 
    210                 215                 220                 


Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
225                 230                 235                 240 


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
                245                 250                 255     


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
            260                 265                 270         


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
        275                 280                 285             


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
    290                 295                 300                 


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
305                 310                 315                 320 


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
                325                 330                 335     


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
            340                 345                 350         


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
        355                 360                 365             


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
    370                 375                 380                 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
385                 390                 395                 400 


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
                405                 410                 415     


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
            420                 425                 


<210>  230
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL7R(316-459)

<400>  230

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
    210                 215                 220                 


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
225                 230                 235                 240 


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe 
                245                 250                 255     


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
            260                 265                 270         


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
        275                 280                 285             


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
    290                 295                 300                 


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
305                 310                 315                 320 


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
                325                 330                 335     


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
            340                 345                 350         


Asn Gln 
        


<210>  231
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL12Rb2(714-862)

<400>  231

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp Pro 
    210                 215                 220                 


Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp Met 
225                 230                 235                 240 


Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala Glu 
                245                 250                 255     


Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly Ser 
            260                 265                 270         


Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala 
        275                 280                 285             


Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp 
    290                 295                 300                 


Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu 
305                 310                 315                 320 


Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His Pro 
                325                 330                 335     


Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys Met 
            340                 345                 350         


Arg Cys Asp Ser Leu Met Leu 
        355                 


<210>  232
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL12Rb2(775-825)

<400>  232

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val 
    210                 215                 220                 


Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn 
225                 230                 235                 240 


Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu 
                245                 250                 255     


Glu Leu Glu Pro Gln 
            260     


<210>  233
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL21R(322-538)

<400>  233

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln 
    210                 215                 220                 


Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe 
225                 230                 235                 240 


Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg 
                245                 250                 255     


Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp 
            260                 265                 270         


Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr 
        275                 280                 285             


Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu 
    290                 295                 300                 


Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val 
305                 310                 315                 320 


Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp 
                325                 330                 335     


Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu 
            340                 345                 350         


Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly 
        355                 360                 365             


Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val 
    370                 375                 380                 


Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly 
385                 390                 395                 400 


Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro 
                405                 410                 415     


Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
            420                 425         


<210>  234
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-EpoR(237-338;L241G,L242P)-IFNAR2(310-515)

<400>  234

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp Glu Ser Asp 
    210                 215                 220                 


Ser Asp Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly Tyr Thr Met 
225                 230                 235                 240 


His Gly Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala Thr Ser Thr 
                245                 250                 255     


Glu Ser Gln Leu Ile Asp Pro Glu Ser Glu Glu Glu Pro Asp Leu Pro 
            260                 265                 270         


Glu Val Asp Val Glu Leu Pro Thr Met Pro Lys Asp Ser Pro Gln Gln 
        275                 280                 285             


Leu Glu Leu Leu Ser Gly Pro Cys Glu Arg Arg Lys Ser Pro Leu Gln 
    290                 295                 300                 


Asp Pro Phe Pro Glu Glu Asp Tyr Ser Ser Thr Glu Gly Ser Gly Gly 
305                 310                 315                 320 


Arg Ile Thr Phe Asn Val Asp Leu Asn Ser Val Phe Leu Arg Val Leu 
                325                 330                 335     


Asp Asp Glu Asp Ser Asp Asp Leu Glu Ala Pro Leu Met Leu Ser Ser 
            340                 345                 350         


His Leu Glu Glu Met Val Asp Pro Glu Asp Pro Asp Asn Val Gln Ser 
        355                 360                 365             


Asn His Leu Leu Ala Ser Gly Glu Gly Thr Gln Pro Thr Phe Pro Ser 
    370                 375                 380                 


Pro Ser Ser Glu Gly Leu Trp Ser Glu Asp Ala Pro Ser Asp Gln Ser 
385                 390                 395                 400 


Asp Thr Ser Glu Ser Asp Val Asp Leu Gly Asp Gly Tyr Ile Met Arg 
                405                 410                 415     


<210>  235
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-EpoR(237-338;L241G,L242P)-IFNAR1(300-520)

<400>  235

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Arg Gly Val Arg Pro Thr Pro Arg Val Arg Ala Pro Ala Thr 
    210                 215                 220                 


Gln Gln Thr Arg Trp Lys Lys Asp Leu Ala Glu Asp Glu Glu Glu Glu 
225                 230                 235                 240 


Asp Glu Glu Asp Thr Glu Asp Gly Val Ser Phe Gln Pro Tyr Ile Glu 
                245                 250                 255     


Pro Pro Ser Phe Leu Gly Gln Glu His Gln Ala Pro Gly His Ser Glu 
            260                 265                 270         


Ala Gly Gly Val Asp Ser Gly Arg Pro Arg Ala Pro Leu Val Pro Ser 
        275                 280                 285             


Glu Gly Ser Ser Ala Trp Asp Ser Ser Asp Arg Ser Trp Ala Ser Thr 
    290                 295                 300                 


Val Asp Ser Ser Trp Asp Arg Ala Gly Ser Ser Gly Tyr Leu Ala Glu 
305                 310                 315                 320 


Lys Gly Pro Gly Gln Gly Pro Gly Gly Asp Gly His Gln Glu Ser Leu 
                325                 330                 335     


Pro Pro Pro Glu Phe Ser Lys Asp Ser Gly Phe Leu Glu Glu Leu Pro 
            340                 345                 350         


Glu Asp Asn Leu Ser Ser Trp Ala Thr Trp Gly Thr Leu Pro Pro Glu 
        355                 360                 365             


Pro Asn Leu Val Pro Gly Gly Pro Pro Val Ser Leu Gln Thr Leu Thr 
    370                 375                 380                 


Phe Cys Trp Glu Ser Ser Pro Glu Glu Glu Glu Glu Ala Arg Glu Ser 
385                 390                 395                 400 


Glu Ile Glu Asp Ser Asp Ala Gly Ser Trp Gly Ala Glu Ser Thr Gln 
                405                 410                 415     


Arg Thr Glu Asp Arg Gly Arg Thr Leu Gly His Tyr Met Ala Arg 
            420                 425                 430     


<210>  236
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-muEpoR(236-337;L264G,L265P)-muIL2Rb(337-539)

<400>  236

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Ala 
            100                 105                 110         


Ser Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Leu Ile Ser Leu Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Thr Leu Gln Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Leu Gln Arg Asp Gly Cys Leu Trp Trp Ser Pro Gly 
            180                 185                 190         


Ser Ser Phe Pro Glu Asp Pro Pro Ala His Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Pro Arg Ala Val Gln Leu Leu Leu Leu Gln Lys Asp Ser Ala Pro Leu 
    210                 215                 220                 


Pro Ser Pro Ser Gly His Ser Gln Ala Ser Cys Phe Thr Asn Gln Gly 
225                 230                 235                 240 


Tyr Phe Phe Phe His Leu Pro Asn Ala Leu Glu Ile Glu Ser Cys Gln 
                245                 250                 255     


Val Tyr Phe Thr Tyr Asp Pro Cys Val Glu Glu Glu Val Glu Glu Asp 
            260                 265                 270         


Gly Ser Arg Leu Pro Glu Gly Ser Pro His Pro Pro Leu Leu Pro Leu 
        275                 280                 285             


Ala Gly Glu Gln Asp Asp Tyr Cys Ala Phe Pro Pro Arg Asp Asp Leu 
    290                 295                 300                 


Leu Leu Phe Ser Pro Ser Leu Ser Thr Pro Asn Thr Ala Tyr Gly Gly 
305                 310                 315                 320 


Ser Arg Ala Pro Glu Glu Arg Ser Pro Leu Ser Leu His Glu Gly Leu 
                325                 330                 335     


Pro Ser Leu Ala Ser Arg Asp Leu Met Gly Leu Gln Arg Pro Leu Glu 
            340                 345                 350         


Arg Met Pro Glu Gly Asp Gly Glu Gly Leu Ser Ala Asn Ser Ser Gly 
        355                 360                 365             


Glu Gln Ala Ser Val Pro Glu Gly Asn Leu His Gly Gln Asp Gln Asp 
    370                 375                 380                 


Arg Gly Gln Gly Pro Ile Leu Thr Leu Asn Thr Asp Ala Tyr Leu Ser 
385                 390                 395                 400 


Leu Gln Glu Leu Gln Ala Gln Asp Ser Val His Leu Ile 
                405                 410             


<210>  237
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-muEpoR(236-337;L264G,L265P)-muIL7R(316-459)

<400>  237

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Ala 
            100                 105                 110         


Ser Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Leu Ile Ser Leu Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Thr Leu Gln Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Leu Gln Arg Asp Gly Cys Leu Trp Trp Ser Pro Gly 
            180                 185                 190         


Ser Ser Phe Pro Glu Asp Pro Pro Ala His Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Pro Arg Ala Arg Asp Glu Val Glu Ser Phe Leu Pro Asn Asp Leu Pro 
    210                 215                 220                 


Ala Gln Pro Glu Glu Leu Glu Thr Gln Gly His Arg Ala Ala Val His 
225                 230                 235                 240 


Ser Ala Asn Arg Ser Pro Glu Thr Ser Val Ser Pro Pro Glu Thr Val 
                245                 250                 255     


Arg Arg Glu Ser Pro Leu Arg Cys Leu Ala Arg Asn Leu Ser Thr Cys 
            260                 265                 270         


Asn Ala Pro Pro Leu Leu Ser Ser Arg Ser Pro Asp Tyr Arg Asp Gly 
        275                 280                 285             


Asp Arg Asn Arg Pro Pro Val Tyr Gln Asp Leu Leu Pro Asn Ser Gly 
    290                 295                 300                 


Asn Thr Asn Val Pro Val Pro Val Pro Gln Pro Leu Pro Phe Gln Ser 
305                 310                 315                 320 


Gly Ile Leu Ile Pro Val Ser Gln Arg Gln Pro Ile Ser Thr Ser Ser 
                325                 330                 335     


Val Leu Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
            340                 345                 350         


Asn Lys 
        


<210>  238
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-EpoR(237-338;L241G,L242P)-IL7R(316-459)-IL12Rb2(775-825)

<400>  238

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
    210                 215                 220                 


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
225                 230                 235                 240 


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe 
                245                 250                 255     


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
            260                 265                 270         


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
        275                 280                 285             


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
    290                 295                 300                 


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
305                 310                 315                 320 


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
                325                 330                 335     


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
            340                 345                 350         


Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val 
        355                 360                 365             


Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn 
    370                 375                 380                 


Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu 
385                 390                 395                 400 


Glu Leu Glu Pro Gln 
                405 


<210>  239
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-GP130(609-700)-IL7R(316-459)-IL12Rb2(775-825)

<400>  239

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Thr Thr Pro Lys 
            100                 105                 110         


Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val Cys Leu Ala 
        115                 120                 125             


Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe Asn Lys Arg 
    130                 135                 140                 


Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp Pro Ser Lys 
145                 150                 155                 160 


Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg His Asn Phe 
                165                 170                 175     


Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr Asp Val Ser 
            180                 185                 190         


Val Val Glu Ile Glu Ala Asn Asp Ala Arg Asp Glu Val Glu Gly Phe 
        195                 200                 205             


Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg 
    210                 215                 220                 


Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val 
225                 230                 235                 240 


Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala 
                245                 250                 255     


Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser 
            260                 265                 270         


Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp 
        275                 280                 285             


Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe 
    290                 295                 300                 


Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln 
305                 310                 315                 320 


Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr 
                325                 330                 335     


Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro 
            340                 345                 350         


Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp 
        355                 360                 365             


Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro 
    370                 375                 380                 


Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390                 395 


<210>  240
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-PrlR(221-319)-IL7R(316-459)-IL12Rb2(775-825)

<400>  240

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ala Thr Phe Ile 
            100                 105                 110         


Gln Ile Pro Ser Asp Phe Thr Met Asn Asp Thr Thr Val Trp Ile Ser 
        115                 120                 125             


Val Ala Val Leu Ser Ala Val Ile Cys Leu Ile Ile Val Trp Ala Val 
    130                 135                 140                 


Ala Leu Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro 
145                 150                 155                 160 


Gly Pro Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys 
                165                 170                 175     


Ser Glu Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr 
            180                 185                 190         


Ser Asp Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ala 
        195                 200                 205             


Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu 
    210                 215                 220                 


Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn 
225                 230                 235                 240 


Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp 
                245                 250                 255     


Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro 
            260                 265                 270         


Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn 
        275                 280                 285             


Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn 
    290                 295                 300                 


Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu 
305                 310                 315                 320 


Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn 
                325                 330                 335     


Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser 
            340                 345                 350         


Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala 
        355                 360                 365             


Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp 
    370                 375                 380                 


Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu 
385                 390                 395                 400 


Pro Gln 
        


<210>  241
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-GHR(251-352)-IL7R(316-459)-IL12Rb2(775-825)

<400>  241

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Leu Pro Gln Met 
            100                 105                 110         


Ser Gln Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile 
        115                 120                 125             


Ile Ile Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu 
    130                 135                 140                 


Phe Ser Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro 
145                 150                 155                 160 


Val Pro Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys 
                165                 170                 175     


Leu Glu Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro 
            180                 185                 190         


Glu Phe His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile 
        195                 200                 205             


Asp Glu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
    210                 215                 220                 


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
225                 230                 235                 240 


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe 
                245                 250                 255     


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
            260                 265                 270         


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
        275                 280                 285             


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
    290                 295                 300                 


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
305                 310                 315                 320 


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
                325                 330                 335     


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
            340                 345                 350         


Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val 
        355                 360                 365             


Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn 
    370                 375                 380                 


Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu 
385                 390                 395                 400 


Glu Leu Glu Pro Gln 
                405 


<210>  242
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-GCSFR(614-710)-IL7R(316-459)-IL12Rb2(775-825)

<400>  242

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Leu Thr Leu Met 
            100                 105                 110         


Thr Leu Thr Pro Glu Gly Ser Glu Leu His Ile Ile Leu Gly Leu Phe 
        115                 120                 125             


Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys Gly Thr Ala Trp Leu Cys 
    130                 135                 140                 


Cys Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro 
145                 150                 155                 160 


Ala His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp 
                165                 170                 175     


Ala Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr 
            180                 185                 190         


Val Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ala Arg Asp 
        195                 200                 205             


Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu 
    210                 215                 220                 


Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro 
225                 230                 235                 240 


Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser 
                245                 250                 255     


Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu 
            260                 265                 270         


Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
        275                 280                 285             


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
    290                 295                 300                 


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
305                 310                 315                 320 


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
                325                 330                 335     


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro 
            340                 345                 350         


Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp 
        355                 360                 365             


Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro 
    370                 375                 380                 


Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390                 395                 400 


<210>  243
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-TPOR/MPLR(478-582)-IL7R(316-459)-IL12Rb2(775-825)

<400>  243

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
    210                 215                 220                 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
                245                 250                 255     


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
            260                 265                 270         


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
        275                 280                 285             


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
    290                 295                 300                 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                325                 330                 335     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            340                 345                 350         


Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro 
        355                 360                 365             


Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu 
    370                 375                 380                 


Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp 
385                 390                 395                 400 


Ser Leu Glu Glu Leu Glu Pro Gln 
                405             


<210>  244
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(376-416)

<400>  244

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
    210                 215                 220                 


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
225                 230                 235                 240 


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                245                 250     


<210>  245
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(424-459)

<400>  245

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile 
    210                 215                 220                 


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
225                 230                 235                 240 


Ser Phe Tyr Gln Asn Gln 
                245     


<210>  246
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(376-416,424-459)

<400>  246

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
    210                 215                 220                 


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
225                 230                 235                 240 


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Gln Gly Gln Pro Ile 
                245                 250                 255     


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
            260                 265                 270         


Ser Phe Tyr Gln Asn Gln 
        275             


<210>  247
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(424-459;Y456F)

<400>  247

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile 
    210                 215                 220                 


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
225                 230                 235                 240 


Ser Phe Phe Gln Asn Gln 
                245     


<210>  248
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL7R(376-416,424-459;Y456F)

<400>  248

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
    210                 215                 220                 


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
225                 230                 235                 240 


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Gln Gly Gln Pro Ile 
                245                 250                 255     


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
            260                 265                 270         


Ser Phe Phe Gln Asn Gln 
        275             


<210>  249
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(393-433)

<400>  249

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln 
    210                 215                 220                 


Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro 
225                 230                 235                 240 


Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser 
                245                 250     


<210>  250
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(518-551)

<400>  250

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu 
    210                 215                 220                 


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
225                 230                 235                 240 


Thr His Leu Val 
                


<210>  251
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(339-379,393-433)

<400>  251

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
    210                 215                 220                 


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
225                 230                 235                 240 


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu Gly Val Ala 
                245                 250                 255     


Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly 
            260                 265                 270         


Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu 
        275                 280                 285             


Phe Ser Pro Ser 
    290         


<210>  252
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(339-379,518-551)

<400>  252

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
    210                 215                 220                 


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
225                 230                 235                 240 


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Gly Gln Gly Glu Phe 
                245                 250                 255     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            260                 265                 270         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285 


<210>  253
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(393-433,518-551)

<400>  253

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln 
    210                 215                 220                 


Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro 
225                 230                 235                 240 


Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe 
                245                 250                 255     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            260                 265                 270         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285 


<210>  254
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-IL2Rb(339-379,393-433,518-551)

<400>  254

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
    210                 215                 220                 


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
225                 230                 235                 240 


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu Gly Val Ala 
                245                 250                 255     


Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly 
            260                 265                 270         


Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu 
        275                 280                 285             


Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu 
    290                 295                 300                 


Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln 
305                 310                 315                 320 


Asp Pro Thr His Leu Val 
                325     


<210>  255
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(955-1186)

<400>  255

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr 
    210                 215                 220                 


Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp 
225                 230                 235                 240 


Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser 
                245                 250                 255     


Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala Thr 
            260                 265                 270         


Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln Ser 
        275                 280                 285             


Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp Pro 
    290                 295                 300                 


Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro Val 
305                 310                 315                 320 


Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser Val 
                325                 330                 335     


Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser Arg 
            340                 345                 350         


Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro Glu 
        355                 360                 365             


Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp Ser 
    370                 375                 380                 


Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn 
385                 390                 395                 400 


Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly 
                405                 410                 415     


Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala 
            420                 425                 430         


Pro Gln Ser Ser Glu Phe Ile Gly Ala 
        435                 440     


<210>  256
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(955-1044,1058-1186;Y974F)

<400>  256

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr 
    210                 215                 220                 


Asp Ser Asn Phe Phe Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp 
225                 230                 235                 240 


Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser 
                245                 250                 255     


Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala Thr 
            260                 265                 270         


Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln Ser 
        275                 280                 285             


Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Ile Asp Asp Thr Phe 
    290                 295                 300                 


Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala 
305                 310                 315                 320 


Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala 
                325                 330                 335     


Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly 
            340                 345                 350         


Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr 
        355                 360                 365             


Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser 
    370                 375                 380                 


Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys 
385                 390                 395                 400 


Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu 
                405                 410                 415     


Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
            420                 425             


<210>  257
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(955-1009;Y974F)

<400>  257

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr 
    210                 215                 220                 


Asp Ser Asn Phe Phe Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp 
225                 230                 235                 240 


Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser 
                245                 250                 255     


Ser Pro Ser Thr Ser Arg Thr Pro 
            260                 


<210>  258
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1019-1085)

<400>  258

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln 
    210                 215                 220                 


Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Ile Asp Asp Thr 
225                 230                 235                 240 


Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro 
                245                 250                 255     


Ala Gly Ser Val Gln Asn Pro Val 
            260                 


<210>  259
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1037-1044,1058-1103;Y1068/1101F)

<400>  259

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Lys Glu Asp Ser Phe Leu Gln Arg Ile Asp Asp Thr Phe Leu 
    210                 215                 220                 


Pro Val Pro Glu Phe Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly 
225                 230                 235                 240 


Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro 
                245                 250                 255     


Ser Arg Asp Pro His Phe Gln Asp 
            260                 


<210>  260
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1066-1118;Y1068/1086F)

<400>  260

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Val Pro Glu Phe Ile Asn Gln Ser Val Pro Lys Arg Pro Ala 
    210                 215                 220                 


Gly Ser Val Gln Asn Pro Val Phe His Asn Gln Pro Leu Asn Pro Ala 
225                 230                 235                 240 


Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly 
                245                 250                 255     


Asn Pro Glu Tyr Leu Asn Thr Val 
            260                 


<210>  261
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1122-1165)

<400>  261

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser 
    210                 215                 220                 


Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile 
225                 230                 235                 240 


Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala 
                245                 250                 255     


Lys Pro Asn Gly Ile Phe Lys Gly 
            260                 


<210>  262
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-EGFR(1133-1186;Y1148F)

<400>  262

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro 
    210                 215                 220                 


Asp Phe Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile 
225                 230                 235                 240 


Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro 
                245                 250                 255     


Gln Ser Ser Glu Phe Ile Gly Ala 
            260                 


<210>  263
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-BLNK(53-208)

<400>  263

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp 
    210                 215                 220                 


Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp Ser Glu 
225                 230                 235                 240 


Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr Glu Pro 
                245                 250                 255     


Pro Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe 
            260                 265                 270         


Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro 
        275                 280                 285             


Pro Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys 
    290                 295                 300                 


Ala Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro 
305                 310                 315                 320 


Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr 
                325                 330                 335     


Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu 
            340                 345                 350         


Ser Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
        355                 360                 365     


<210>  264
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-BLNK(53-208;Y72F)

<400>  264

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp 
    210                 215                 220                 


Asp Phe Asp Ser Asp Phe Glu Asn Pro Asp Glu His Ser Asp Ser Glu 
225                 230                 235                 240 


Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr Glu Pro 
                245                 250                 255     


Pro Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe 
            260                 265                 270         


Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro 
        275                 280                 285             


Pro Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys 
    290                 295                 300                 


Ala Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro 
305                 310                 315                 320 


Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr 
                325                 330                 335     


Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu 
            340                 345                 350         


Ser Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
        355                 360                 365     


<210>  265
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- EpoR(237-338;L241G,L242P)-BLNK(53-208;Y72F,Y96F)

<400>  265

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Glu Pro Val 
            100                 105                 110         


Ser Gly Pro Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
        115                 120                 125             


Leu Ile Leu Val Val Ile Leu Val Gly Pro Thr Val Leu Ala Leu Leu 
    130                 135                 140                 


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
145                 150                 155                 160 


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
                165                 170                 175     


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
            180                 185                 190         


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
        195                 200                 205             


Arg Cys Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp 
    210                 215                 220                 


Asp Phe Asp Ser Asp Phe Glu Asn Pro Asp Glu His Ser Asp Ser Glu 
225                 230                 235                 240 


Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Phe Glu Pro 
                245                 250                 255     


Pro Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe 
            260                 265                 270         


Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro 
        275                 280                 285             


Pro Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys 
    290                 295                 300                 


Ala Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro 
305                 310                 315                 320 


Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr 
                325                 330                 335     


Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu 
            340                 345                 350         


Ser Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
        355                 360                 365     


<210>  266
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)

<400>  266

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
    210                 215                 220                 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
                245                 250                 255     


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
            260                 265                 270         


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
        275                 280                 285             


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
    290                 295                 300                 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                325                 330                 335     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            340                 345                 350         


Phe Tyr Gln Asn Gln 
        355         


<210>  267
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rb(333-551)

<400>  267

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val 
    210                 215                 220                 


Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe 
225                 230                 235                 240 


Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile 
                245                 250                 255     


Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp 
            260                 265                 270         


Pro Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro 
        275                 280                 285             


Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser 
    290                 295                 300                 


Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser 
305                 310                 315                 320 


Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met 
                325                 330                 335     


Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro 
            340                 345                 350         


Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro 
        355                 360                 365             


Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala 
    370                 375                 380                 


Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln 
385                 390                 395                 400 


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
                405                 410                 415     


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
            420                 425                 430         


<210>  268
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(393-433,518-551)

<400>  268

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser 
    210                 215                 220                 


Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys 
225                 230                 235                 240 


Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln 
                245                 250                 255     


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
            260                 265                 270         


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285             


<210>  269
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(339-379,393-433,518-551)

<400>  269

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu 
    210                 215                 220                 


Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
225                 230                 235                 240 


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu 
                245                 250                 255     


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
            260                 265                 270         


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
        275                 280                 285             


Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn 
    290                 295                 300                 


Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu 
305                 310                 315                 320 


Gln Gly Gln Asp Pro Thr His Leu Val 
                325                 


<210>  270
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)-IL12Rb2(775-825)

<400>  270

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
    210                 215                 220                 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
                245                 250                 255     


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
            260                 265                 270         


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
        275                 280                 285             


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
    290                 295                 300                 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                325                 330                 335     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            340                 345                 350         


Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro 
        355                 360                 365             


Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu 
    370                 375                 380                 


Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp 
385                 390                 395                 400 


Ser Leu Glu Glu Leu Glu Pro Gln 
                405             


<210>  271
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)-IL21R(322-538)

<400>  271

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
    210                 215                 220                 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
                245                 250                 255     


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
            260                 265                 270         


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
        275                 280                 285             


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
    290                 295                 300                 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                325                 330                 335     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            340                 345                 350         


Phe Tyr Gln Asn Gln Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr 
        355                 360                 365             


Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys 
    370                 375                 380                 


Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser 
385                 390                 395                 400 


Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr 
                405                 410                 415     


Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp 
            420                 425                 430         


Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro 
        435                 440                 445             


Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys 
    450                 455                 460                 


Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser 
465                 470                 475                 480 


Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala 
                485                 490                 495     


Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser 
            500                 505                 510         


Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser 
        515                 520                 525             


Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr 
    530                 535                 540                 


Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val 
545                 550                 555                 560 


Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
                565                 570                 


<210>  272
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)- IL21R(322-538)-IL7R(316-459)

<400>  272

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr 
    210                 215                 220                 


Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys 
225                 230                 235                 240 


Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser 
                245                 250                 255     


Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr 
            260                 265                 270         


Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp 
        275                 280                 285             


Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro 
    290                 295                 300                 


Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys 
305                 310                 315                 320 


Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser 
                325                 330                 335     


Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala 
            340                 345                 350         


Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser 
        355                 360                 365             


Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser 
    370                 375                 380                 


Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr 
385                 390                 395                 400 


Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val 
                405                 410                 415     


Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser Ala Arg 
            420                 425                 430         


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
        435                 440                 445             


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
    450                 455                 460                 


Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser 
465                 470                 475                 480 


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
                485                 490                 495     


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
            500                 505                 510         


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
        515                 520                 525             


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
    530                 535                 540                 


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
545                 550                 555                 560 


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
                565                 570                 


<210>  273
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(393-433,518-551)-IL21R(322-538)

<400>  273

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser 
    210                 215                 220                 


Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys 
225                 230                 235                 240 


Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln 
                245                 250                 255     


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
            260                 265                 270         


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285             


Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro 
    290                 295                 300                 


Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp Pro 
305                 310                 315                 320 


Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg 
                325                 330                 335     


Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu 
            340                 345                 350         


Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala 
        355                 360                 365             


Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro 
    370                 375                 380                 


Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala 
385                 390                 395                 400 


Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu 
                405                 410                 415     


Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp 
            420                 425                 430         


Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro 
        435                 440                 445             


Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser 
    450                 455                 460                 


Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu 
465                 470                 475                 480 


Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro 
                485                 490                 495     


Leu Ser Ser Pro Gly Pro Gln Ala Ser 
            500                 505 


<210>  274
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)- IL21R(322-538)-IL2Rbsmall(393-433,518-551)

<400>  274

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr 
    210                 215                 220                 


Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys 
225                 230                 235                 240 


Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser 
                245                 250                 255     


Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr 
            260                 265                 270         


Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp 
        275                 280                 285             


Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro 
    290                 295                 300                 


Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys 
305                 310                 315                 320 


Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser 
                325                 330                 335     


Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala 
            340                 345                 350         


Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser 
        355                 360                 365             


Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser 
    370                 375                 380                 


Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr 
385                 390                 395                 400 


Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val 
                405                 410                 415     


Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser Asp Glu 
            420                 425                 430         


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
        435                 440                 445             


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
    450                 455                 460                 


Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn 
465                 470                 475                 480 


Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu 
                485                 490                 495     


Gln Gly Gln Asp Pro Thr His Leu Val 
            500                 505 


<210>  275
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(339-379,393-433,518-551)-IL21R(322-538)

<400>  275

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu 
    210                 215                 220                 


Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
225                 230                 235                 240 


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu 
                245                 250                 255     


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
            260                 265                 270         


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
        275                 280                 285             


Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn 
    290                 295                 300                 


Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu 
305                 310                 315                 320 


Gln Gly Gln Asp Pro Thr His Leu Val Pro Arg Ser Pro Ala Lys Arg 
                325                 330                 335     


Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp 
            340                 345                 350         


Gly Val Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly 
        355                 360                 365             


Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile 
    370                 375                 380                 


Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys 
385                 390                 395                 400 


Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu 
                405                 410                 415     


Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr 
            420                 425                 430         


Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly 
        435                 440                 445             


Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly 
    450                 455                 460                 


Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly 
465                 470                 475                 480 


Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp 
                485                 490                 495     


Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu 
            500                 505                 510         


Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu 
        515                 520                 525             


Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln 
    530                 535                 540                 


Ala Ser 
545     


<210>  276
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)- IL21R(322-538)-IL2Rbsmall(339-379,393-433,518-551)

<400>  276

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr 
    210                 215                 220                 


Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys 
225                 230                 235                 240 


Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser 
                245                 250                 255     


Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr 
            260                 265                 270         


Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp 
        275                 280                 285             


Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro 
    290                 295                 300                 


Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys 
305                 310                 315                 320 


Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser 
                325                 330                 335     


Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala 
            340                 345                 350         


Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser 
        355                 360                 365             


Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser 
    370                 375                 380                 


Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr 
385                 390                 395                 400 


Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val 
                405                 410                 415     


Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser Gln Gln 
            420                 425                 430         


Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr 
        435                 440                 445             


Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala 
    450                 455                 460                 


Leu Glu Ile Glu Ala Cys Gln Asp Glu Gly Val Ala Gly Ala Pro Thr 
465                 470                 475                 480 


Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala 
                485                 490                 495     


Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser 
            500                 505                 510         


Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr 
        515                 520                 525             


Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His 
    530                 535                 540                 


Leu Val 
545     


<210>  277
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL2Rbsmall(393-433,518-551)-IL7R(316-459)

<400>  277

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser 
    210                 215                 220                 


Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys 
225                 230                 235                 240 


Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln 
                245                 250                 255     


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
            260                 265                 270         


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285             


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
    290                 295                 300                 


Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro 
305                 310                 315                 320 


Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg 
                325                 330                 335     


Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala 
            340                 345                 350         


Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys 
        355                 360                 365             


Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr 
    370                 375                 380                 


Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr 
385                 390                 395                 400 


Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser 
                405                 410                 415     


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
            420                 425                 430         


<210>  278
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)-IL2Rbsmall(393-433,518-551)

<400>  278

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
    210                 215                 220                 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
                245                 250                 255     


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
            260                 265                 270         


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
        275                 280                 285             


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
    290                 295                 300                 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                325                 330                 335     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            340                 345                 350         


Phe Tyr Gln Asn Gln Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser 
        355                 360                 365             


Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys 
    370                 375                 380                 


Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Gly Gln 
385                 390                 395                 400 


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
                405                 410                 415     


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
            420                 425                 430         


<210>  279
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)- IL2Rbsmall(339-379,393-433,518-551)-IL7R(316-459)

<400>  279

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu 
    210                 215                 220                 


Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
225                 230                 235                 240 


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu 
                245                 250                 255     


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
            260                 265                 270         


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
        275                 280                 285             


Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn 
    290                 295                 300                 


Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu 
305                 310                 315                 320 


Gln Gly Gln Asp Pro Thr His Leu Val Ala Arg Asp Glu Val Glu Gly 
                325                 330                 335     


Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln 
            340                 345                 350         


Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val 
        355                 360                 365             


Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu 
    370                 375                 380                 


Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg 
385                 390                 395                 400 


Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln 
                405                 410                 415     


Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro 
            420                 425                 430         


Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly 
        435                 440                 445             


Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val 
    450                 455                 460                 


Thr Met Ser Ser Phe Tyr Gln Asn Gln 
465                 470             


<210>  280
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)- IL2Rbsmall(339-379,393-433,518-551)

<400>  280

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
    210                 215                 220                 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
                245                 250                 255     


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
            260                 265                 270         


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
        275                 280                 285             


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
    290                 295                 300                 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                325                 330                 335     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            340                 345                 350         


Phe Tyr Gln Asn Gln Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu 
        355                 360                 365             


Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
    370                 375                 380                 


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Asp Glu 
385                 390                 395                 400 


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
                405                 410                 415     


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
            420                 425                 430         


Leu Leu Leu Phe Ser Pro Ser Gly Gln Gly Glu Phe Arg Ala Leu Asn 
        435                 440                 445             


Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu 
    450                 455                 460                 


Gln Gly Gln Asp Pro Thr His Leu Val 
465                 470             


<210>  281
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)-PD1(156-191)-TPOR/MPLR (514-582)-IL7R(316-459)-IL12Rb2(775-825)

<400>  281

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Pro Ser Pro Ser 
            100                 105                 110         


Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly 
        115                 120                 125             


Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
    210                 215                 220                 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
                245                 250                 255     


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
            260                 265                 270         


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
        275                 280                 285             


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
    290                 295                 300                 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                325                 330                 335     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            340                 345                 350         


Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro 
        355                 360                 365             


Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu 
    370                 375                 380                 


Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp 
385                 390                 395                 400 


Ser Leu Glu Glu Leu Glu Pro Gln 
                405             


<210>  282
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-EGFR(1122-1165)

<400>  282

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys 
    210                 215                 220                 


Val Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser 
225                 230                 235                 240 


His Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro 
                245                 250                 255     


Lys Glu Ala Lys Pro Asn Gly Ile Phe Lys Gly 
            260                 265         


<210>  283
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582)-IL7R(316-459)-IL12Rb2(775-825)FKBP switch containing  wildtype TpoR TM sequence

<400>  283

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala 
        115                 120                 125             


Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu 
    130                 135                 140                 


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
145                 150                 155                 160 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
                165                 170                 175     


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
            180                 185                 190         


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
        195                 200                 205             


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
    210                 215                 220                 


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
                245                 250                 255     


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
            260                 265                 270         


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
        275                 280                 285             


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
    290                 295                 300                 


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
                325                 330                 335     


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
            340                 345                 350         


Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro 
        355                 360                 365             


Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu 
    370                 375                 380                 


Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp 
385                 390                 395                 400 


Ser Leu Glu Glu Leu Glu Pro Gln 
                405             


<210>  284
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-1)-IL7R(316-459)-IL12Rb2(775-825)

<400>  284

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Trp Ile Ser Leu Val Thr Ala Leu 
        115                 120                 125             


His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg 
    130                 135                 140                 


Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro 
145                 150                 155                 160 


Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr 
                165                 170                 175     


Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu 
            180                 185                 190         


Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr 
        195                 200                 205             


Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr 
    210                 215                 220                 


Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp 
225                 230                 235                 240 


Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu 
                245                 250                 255     


Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser 
            260                 265                 270         


Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg 
        275                 280                 285             


Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser 
    290                 295                 300                 


Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser 
305                 310                 315                 320 


Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr 
                325                 330                 335     


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
            340                 345                 350         


Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp 
        355                 360                 365             


Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro 
    370                 375                 380                 


Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser 
385                 390                 395                 400 


Leu Glu Glu Leu Glu Pro Gln 
                405         


<210>  285
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-2)-IL7R(316-459)-IL12Rb2(775-825)

<400>  285

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ile Ser Leu Val Thr Ala Leu His 
        115                 120                 125             


Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp 
    130                 135                 140                 


Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser 
145                 150                 155                 160 


Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala 
                165                 170                 175     


Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val 
            180                 185                 190         


Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro 
        195                 200                 205             


Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    210                 215                 220                 


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
225                 230                 235                 240 


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                245                 250                 255     


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            260                 265                 270         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        275                 280                 285             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    290                 295                 300                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
305                 310                 315                 320 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                325                 330                 335     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            340                 345                 350         


Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr 
        355                 360                 365             


Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser 
    370                 375                 380                 


Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu 
385                 390                 395                 400 


Glu Glu Leu Glu Pro Gln 
                405     


<210>  286
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-2+1)-IL7R(316-459)-IL12Rb2(775-825)

<400>  286

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Leu Ile Ser Leu Val Thr Ala Leu 
        115                 120                 125             


His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg 
    130                 135                 140                 


Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro 
145                 150                 155                 160 


Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr 
                165                 170                 175     


Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu 
            180                 185                 190         


Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr 
        195                 200                 205             


Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr 
    210                 215                 220                 


Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp 
225                 230                 235                 240 


Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu 
                245                 250                 255     


Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser 
            260                 265                 270         


Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg 
        275                 280                 285             


Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser 
    290                 295                 300                 


Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser 
305                 310                 315                 320 


Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr 
                325                 330                 335     


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
            340                 345                 350         


Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp 
        355                 360                 365             


Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro 
    370                 375                 380                 


Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser 
385                 390                 395                 400 


Leu Glu Glu Leu Glu Pro Gln 
                405         


<210>  287
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-3)-IL7R(316-459)-IL12Rb2(775-825)

<400>  287

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ser Leu Val Thr Ala Leu His Leu 
        115                 120                 125             


Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln 
    130                 135                 140                 


Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu 
145                 150                 155                 160 


Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala 
                165                 170                 175     


Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu 
            180                 185                 190         


Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu 
        195                 200                 205             


Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
    210                 215                 220                 


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
225                 230                 235                 240 


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe 
                245                 250                 255     


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
            260                 265                 270         


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
        275                 280                 285             


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
    290                 295                 300                 


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
305                 310                 315                 320 


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
                325                 330                 335     


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
            340                 345                 350         


Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val 
        355                 360                 365             


Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn 
    370                 375                 380                 


Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu 
385                 390                 395                 400 


Glu Leu Glu Pro Gln 
                405 


<210>  288
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-4)-IL7R(316-459)-IL12Rb2(775-825)

<400>  288

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Leu Val Thr Ala Leu His Leu Val 
        115                 120                 125             


Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe 
    130                 135                 140                 


Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro 
145                 150                 155                 160 


Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu 
                165                 170                 175     


Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro 
            180                 185                 190         


Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro 
        195                 200                 205             


Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln 
    210                 215                 220                 


Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser 
225                 230                 235                 240 


Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly 
                245                 250                 255     


Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp 
            260                 265                 270         


Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly 
        275                 280                 285             


Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr 
    290                 295                 300                 


Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu 
305                 310                 315                 320 


Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly 
                325                 330                 335     


Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
            340                 345                 350         


Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu 
        355                 360                 365             


Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile 
    370                 375                 380                 


Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu 
385                 390                 395                 400 


Leu Glu Pro Gln 
                


<210>  289
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-4+1)-IL7R(316-459)-IL12Rb2(775-825)

<400>  289

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ile Leu Val Thr Ala Leu His Leu 
        115                 120                 125             


Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln 
    130                 135                 140                 


Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu 
145                 150                 155                 160 


Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala 
                165                 170                 175     


Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu 
            180                 185                 190         


Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu 
        195                 200                 205             


Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
    210                 215                 220                 


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
225                 230                 235                 240 


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe 
                245                 250                 255     


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
            260                 265                 270         


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
        275                 280                 285             


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
    290                 295                 300                 


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
305                 310                 315                 320 


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
                325                 330                 335     


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
            340                 345                 350         


Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val 
        355                 360                 365             


Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn 
    370                 375                 380                 


Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu 
385                 390                 395                 400 


Glu Leu Glu Pro Gln 
                405 


<210>  290
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-5)-IL7R(316-459)-IL12Rb2(775-825)

<400>  290

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Val Thr Ala Leu His Leu Val Leu 
        115                 120                 125             


Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro 
    130                 135                 140                 


Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp 
145                 150                 155                 160 


Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser 
                165                 170                 175     


Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser 
            180                 185                 190         


Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu 
        195                 200                 205             


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
    210                 215                 220                 


Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro 
225                 230                 235                 240 


Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg 
                245                 250                 255     


Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala 
            260                 265                 270         


Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys 
        275                 280                 285             


Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr 
    290                 295                 300                 


Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr 
305                 310                 315                 320 


Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser 
                325                 330                 335     


Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
            340                 345                 350         


Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro 
        355                 360                 365             


Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
    370                 375                 380                 


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
385                 390                 395                 400 


Glu Pro Gln 
            


<210>  291
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-6)-IL7R(316-459)-IL12Rb2(775-825)

<400>  291

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Thr Ala Leu His Leu Val Leu Gly 
        115                 120                 125             


Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala 
    130                 135                 140                 


His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu 
145                 150                 155                 160 


His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro 
                165                 170                 175     


Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu 
            180                 185                 190         


Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala 
        195                 200                 205             


Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu 
    210                 215                 220                 


Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn 
225                 230                 235                 240 


Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp 
                245                 250                 255     


Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro 
            260                 265                 270         


Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn 
        275                 280                 285             


Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn 
    290                 295                 300                 


Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu 
305                 310                 315                 320 


Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn 
                325                 330                 335     


Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser 
            340                 345                 350         


Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala 
        355                 360                 365             


Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp 
    370                 375                 380                 


Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu 
385                 390                 395                 400 


Pro Gln 
        


<210>  292
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-7)-IL7R(316-459)-IL12Rb2(775-825)

<400>  292

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Leu His Leu Val Leu Gly Leu 
        115                 120                 125             


Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His 
    130                 135                 140                 


Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His 
145                 150                 155                 160 


Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro 
                165                 170                 175     


Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu 
            180                 185                 190         


Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg 
        195                 200                 205             


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
    210                 215                 220                 


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
225                 230                 235                 240 


Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser 
                245                 250                 255     


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
            260                 265                 270         


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
        275                 280                 285             


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
    290                 295                 300                 


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
305                 310                 315                 320 


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
                325                 330                 335     


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp 
            340                 345                 350         


Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly 
        355                 360                 365             


Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu 
    370                 375                 380                 


Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro 
385                 390                 395                 400 


Gln 
    


<210>  293
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-8)-IL7R(316-459)-IL12Rb2(775-825)

<400>  293

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Leu His Leu Val Leu Gly Leu Ser 
        115                 120                 125             


Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr 
    130                 135                 140                 


Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg 
145                 150                 155                 160 


Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys 
                165                 170                 175     


Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu 
            180                 185                 190         


Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp 
        195                 200                 205             


Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu 
    210                 215                 220                 


Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro 
225                 230                 235                 240 


Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser 
                245                 250                 255     


Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu 
            260                 265                 270         


Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
        275                 280                 285             


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
    290                 295                 300                 


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
305                 310                 315                 320 


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
                325                 330                 335     


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro 
            340                 345                 350         


Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp 
        355                 360                 365             


Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro 
    370                 375                 380                 


Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390                 395                 400 


<210>  294
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-9)-IL7R(316-459)-IL12Rb2(775-825)

<400>  294

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr His Leu Val Leu Gly Leu Ser Ala 
        115                 120                 125             


Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg 
    130                 135                 140                 


Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val 
145                 150                 155                 160 


Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala 
                165                 170                 175     


Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile 
            180                 185                 190         


Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu 
        195                 200                 205             


Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser 
    210                 215                 220                 


Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser 
225                 230                 235                 240 


Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu 
                245                 250                 255     


Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser 
            260                 265                 270         


Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His 
        275                 280                 285             


Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu 
    290                 295                 300                 


Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val 
305                 310                 315                 320 


Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu 
                325                 330                 335     


Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys 
            340                 345                 350         


Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu 
        355                 360                 365             


Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser 
    370                 375                 380                 


His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390                 395                 


<210>  295
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-10)-IL7R(316-459)-IL12Rb2(775-825)

<400>  295

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Leu Val Leu Gly Leu Ser Ala Val 
        115                 120                 125             


Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg 
    130                 135                 140                 


Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu 
145                 150                 155                 160 


Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr 
                165                 170                 175     


Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu 
            180                 185                 190         


Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val 
        195                 200                 205             


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
    210                 215                 220                 


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
225                 230                 235                 240 


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
                245                 250                 255     


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
            260                 265                 270         


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
        275                 280                 285             


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
    290                 295                 300                 


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
305                 310                 315                 320 


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
                325                 330                 335     


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro 
            340                 345                 350         


Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro 
        355                 360                 365             


Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His 
    370                 375                 380                 


Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390                 395             


<210>  296
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-11)-IL7R(316-459)-IL12Rb2(775-825)

<400>  296

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Val Leu Gly Leu Ser Ala Val Leu 
        115                 120                 125             


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
    130                 135                 140                 


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
145                 150                 155                 160 


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
                165                 170                 175     


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
            180                 185                 190         


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
        195                 200                 205             


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
    210                 215                 220                 


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
225                 230                 235                 240 


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
                245                 250                 255     


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
            260                 265                 270         


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
        275                 280                 285             


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
    290                 295                 300                 


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
305                 310                 315                 320 


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
                325                 330                 335     


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu 
            340                 345                 350         


Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr 
        355                 360                 365             


His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu 
    370                 375                 380                 


Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390                 395         


<210>  297
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-12)-IL7R(316-459)-IL12Rb2(775-825)

<400>  297

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Leu Gly Leu Ser Ala Val Leu Gly 
        115                 120                 125             


Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
    130                 135                 140                 


His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln 
145                 150                 155                 160 


Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser 
                165                 170                 175     


Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys 
            180                 185                 190         


Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly 
        195                 200                 205             


Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln 
    210                 215                 220                 


Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val 
225                 230                 235                 240 


Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu 
                245                 250                 255     


Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg 
            260                 265                 270         


Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln 
        275                 280                 285             


Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro 
    290                 295                 300                 


Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly 
305                 310                 315                 320 


Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val 
                325                 330                 335     


Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn 
            340                 345                 350         


Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His 
        355                 360                 365             


Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala 
    370                 375                 380                 


Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390                 395     


<210>  298
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-13)-IL7R(316-459)-IL12Rb2(775-825)

<400>  298

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Gly Leu Ser Ala Val Leu Gly Leu 
        115                 120                 125             


Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His 
    130                 135                 140                 


Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr 
145                 150                 155                 160 


Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp 
                165                 170                 175     


Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser 
            180                 185                 190         


Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe 
        195                 200                 205             


Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg 
    210                 215                 220                 


Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val 
225                 230                 235                 240 


Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala 
                245                 250                 255     


Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser 
            260                 265                 270         


Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp 
        275                 280                 285             


Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe 
    290                 295                 300                 


Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln 
305                 310                 315                 320 


Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr 
                325                 330                 335     


Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro 
            340                 345                 350         


Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp 
        355                 360                 365             


Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro 
    370                 375                 380                 


Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390                 395 


<210>  299
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-14)-IL7R(316-459)-IL12Rb2(775-825)

<400>  299

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Leu Ser Ala Val Leu Gly Leu Leu 
        115                 120                 125             


Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala 
    130                 135                 140                 


Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu 
145                 150                 155                 160 


Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr 
                165                 170                 175     


Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser 
            180                 185                 190         


Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu 
        195                 200                 205             


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
    210                 215                 220                 


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
225                 230                 235                 240 


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
                245                 250                 255     


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
            260                 265                 270         


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
        275                 280                 285             


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
    290                 295                 300                 


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
305                 310                 315                 320 


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
                325                 330                 335     


Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala 
            340                 345                 350         


Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly 
        355                 360                 365             


Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu 
    370                 375                 380                 


Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390                 


<210>  300
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-15)-IL7R(316-459)-IL12Rb2(775-825)

<400>  300

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ser Ala Val Leu Gly Leu Leu Leu 
        115                 120                 125             


Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu 
    130                 135                 140                 


Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg 
145                 150                 155                 160 


Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys 
                165                 170                 175     


Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu 
            180                 185                 190         


Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln 
        195                 200                 205             


Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly 
    210                 215                 220                 


Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr 
225                 230                 235                 240 


Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn 
                245                 250                 255     


Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
            260                 265                 270         


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
        275                 280                 285             


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu 
    290                 295                 300                 


Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile 
305                 310                 315                 320 


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
                325                 330                 335     


Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
            340                 345                 350         


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
        355                 360                 365             


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
    370                 375                 380                 


Asp Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390             


<210>  301
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-16)-IL7R(316-459)-IL12Rb2(775-825)

<400>  301

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Val Leu Gly Leu Leu Leu Leu 
        115                 120                 125             


Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
    130                 135                 140                 


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
145                 150                 155                 160 


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
                165                 170                 175     


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
            180                 185                 190         


Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
        195                 200                 205             


Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly 
    210                 215                 220                 


Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro 
225                 230                 235                 240 


Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val 
                245                 250                 255     


Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys 
            260                 265                 270         


Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu 
        275                 280                 285             


Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln 
    290                 295                 300                 


Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu 
305                 310                 315                 320 


Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser 
                325                 330                 335     


Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro 
            340                 345                 350         


Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu 
        355                 360                 365             


Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp 
    370                 375                 380                 


Ser Leu Glu Glu Leu Glu Pro Gln 
385                 390         


<210>  302
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-17)-IL7R(316-459)-IL12Rb2(775-825)

<400>  302

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Val Leu Gly Leu Leu Leu Leu Arg 
        115                 120                 125             


Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro 
    130                 135                 140                 


Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr 
145                 150                 155                 160 


Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu 
                165                 170                 175     


Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr 
            180                 185                 190         


Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr 
        195                 200                 205             


Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp 
    210                 215                 220                 


Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu 
225                 230                 235                 240 


Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser 
                245                 250                 255     


Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg 
            260                 265                 270         


Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser 
        275                 280                 285             


Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser 
    290                 295                 300                 


Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr 
305                 310                 315                 320 


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
                325                 330                 335     


Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp 
            340                 345                 350         


Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro 
        355                 360                 365             


Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser 
    370                 375                 380                 


Leu Glu Glu Leu Glu Pro Gln 
385                 390     


<210>  303
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N-18)-IL7R(316-459)-IL12Rb2(775-825)

<400>  303

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Leu Gly Leu Leu Leu Leu Arg Trp 
        115                 120                 125             


Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser 
    130                 135                 140                 


Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala 
145                 150                 155                 160 


Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val 
                165                 170                 175     


Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro 
            180                 185                 190         


Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
        195                 200                 205             


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
    210                 215                 220                 


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
225                 230                 235                 240 


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
                245                 250                 255     


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
            260                 265                 270         


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
        275                 280                 285             


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
    290                 295                 300                 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
305                 310                 315                 320 


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
                325                 330                 335     


Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr 
            340                 345                 350         


Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser 
        355                 360                 365             


Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu 
    370                 375                 380                 


Glu Glu Leu Glu Pro Gln 
385                 390 


<210>  304
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N+1)-IL7R(316-459)-IL12Rb2(775-825)

<400>  304

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Ile Ser Leu Val Thr 
        115                 120                 125             


Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu 
    130                 135                 140                 


Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu 
145                 150                 155                 160 


Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg 
                165                 170                 175     


Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys 
            180                 185                 190         


Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu 
        195                 200                 205             


Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu Gln 
    210                 215                 220                 


Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly 
225                 230                 235                 240 


Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr 
                245                 250                 255     


Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn 
            260                 265                 270         


Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp 
        275                 280                 285             


Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu 
    290                 295                 300                 


Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu 
305                 310                 315                 320 


Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile 
                325                 330                 335     


Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser 
            340                 345                 350         


Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
        355                 360                 365             


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
    370                 375                 380                 


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
385                 390                 395                 400 


Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 


<210>  305
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N+2)-IL7R(316-459)-IL12Rb2(775-825)

<400>  305

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Val Leu Ile Ser Leu Val 
        115                 120                 125             


Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu 
    130                 135                 140                 


Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala 
145                 150                 155                 160 


Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu 
                165                 170                 175     


Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr 
            180                 185                 190         


Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser 
        195                 200                 205             


Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe Leu 
    210                 215                 220                 


Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu 
225                 230                 235                 240 


Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile 
                245                 250                 255     


Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly 
            260                 265                 270         


Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu 
        275                 280                 285             


Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
    290                 295                 300                 


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
305                 310                 315                 320 


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
                325                 330                 335     


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
            340                 345                 350         


Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro Ala 
        355                 360                 365             


Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly 
    370                 375                 380                 


Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu 
385                 390                 395                 400 


Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410 


<210>  306
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N+3)-IL7R(316-459)-IL12Rb2(775-825)

<400>  306

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Val Leu Ile Ser Leu 
        115                 120                 125             


Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu 
    130                 135                 140                 


Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His 
145                 150                 155                 160 


Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr 
                165                 170                 175     


Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp 
            180                 185                 190         


Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser 
        195                 200                 205             


Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly Phe 
    210                 215                 220                 


Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg 
225                 230                 235                 240 


Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val 
                245                 250                 255     


Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala 
            260                 265                 270         


Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser 
        275                 280                 285             


Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp 
    290                 295                 300                 


Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe 
305                 310                 315                 320 


Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln 
                325                 330                 335     


Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr 
            340                 345                 350         


Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn Pro 
        355                 360                 365             


Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp 
    370                 375                 380                 


Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro 
385                 390                 395                 400 


Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410     


<210>  307
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N+4)-IL7R(316-459)-IL12Rb2(775-825)

<400>  307

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Leu Val Leu Ile Ser 
        115                 120                 125             


Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly 
    130                 135                 140                 


Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg 
145                 150                 155                 160 


His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln 
                165                 170                 175     


Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser 
            180                 185                 190         


Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys 
        195                 200                 205             


Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu Gly 
    210                 215                 220                 


Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln 
225                 230                 235                 240 


Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val 
                245                 250                 255     


Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu 
            260                 265                 270         


Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg 
        275                 280                 285             


Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln 
    290                 295                 300                 


Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro 
305                 310                 315                 320 


Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly 
                325                 330                 335     


Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val 
            340                 345                 350         


Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu Asn 
        355                 360                 365             


Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His 
    370                 375                 380                 


Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala 
385                 390                 395                 400 


Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410         


<210>  308
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N+5)-IL7R(316-459)-IL12Rb2(775-825)

<400>  308

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Ile Leu Val Leu Ile 
        115                 120                 125             


Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu 
    130                 135                 140                 


Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu 
145                 150                 155                 160 


Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly 
                165                 170                 175     


Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val 
            180                 185                 190         


Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro 
        195                 200                 205             


Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val Glu 
    210                 215                 220                 


Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys 
225                 230                 235                 240 


Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp 
                245                 250                 255     


Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys 
            260                 265                 270         


Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser 
        275                 280                 285             


Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr 
    290                 295                 300                 


Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro 
305                 310                 315                 320 


Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln 
                325                 330                 335     


Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr 
            340                 345                 350         


Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro Glu 
        355                 360                 365             


Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr 
    370                 375                 380                 


His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu 
385                 390                 395                 400 


Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410             


<210>  309
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N+6)-IL7R(316-459)-IL12Rb2(775-825)

<400>  309

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Leu Ile Leu Val Leu 
        115                 120                 125             


Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val 
    130                 135                 140                 


Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg 
145                 150                 155                 160 


Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu 
                165                 170                 175     


Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr 
            180                 185                 190         


Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu 
        195                 200                 205             


Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu Val 
    210                 215                 220                 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
225                 230                 235                 240 


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
                245                 250                 255     


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
            260                 265                 270         


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
        275                 280                 285             


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
    290                 295                 300                 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
305                 310                 315                 320 


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
                325                 330                 335     


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
            340                 345                 350         


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys Pro 
        355                 360                 365             


Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro 
    370                 375                 380                 


Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His 
385                 390                 395                 400 


Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410                 


<210>  310
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N+7)-IL7R(316-459)-IL12Rb2(775-825)

<400>  310

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Val Leu Leu Ile Leu Val 
        115                 120                 125             


Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala 
    130                 135                 140                 


Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr Arg 
145                 150                 155                 160 


Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val 
                165                 170                 175     


Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala 
            180                 185                 190         


Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu Ile 
        195                 200                 205             


Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp Glu 
    210                 215                 220                 


Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser 
225                 230                 235                 240 


Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser 
                245                 250                 255     


Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu 
            260                 265                 270         


Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser 
        275                 280                 285             


Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His 
    290                 295                 300                 


Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu 
305                 310                 315                 320 


Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val 
                325                 330                 335     


Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu 
            340                 345                 350         


Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro Lys 
        355                 360                 365             


Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp Leu 
    370                 375                 380                 


Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser 
385                 390                 395                 400 


His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410                 415 


<210>  311
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FKBP(F36V)- TPOR/MPLR(478-582;N+7)-IL7R(316-459)-IL12Rb2(775-825)

<400>  311

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asp Pro Thr 
            100                 105                 110         


Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Leu Val Leu Leu Ile Leu 
        115                 120                 125             


Val Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser 
    130                 135                 140                 


Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala His Tyr 
145                 150                 155                 160 


Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg 
                165                 170                 175     


Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys 
            180                 185                 190         


Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu 
        195                 200                 205             


Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Ala Arg Asp 
    210                 215                 220                 


Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu 
225                 230                 235                 240 


Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro 
                245                 250                 255     


Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser 
            260                 265                 270         


Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu 
        275                 280                 285             


Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
    290                 295                 300                 


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
305                 310                 315                 320 


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
                325                 330                 335     


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
            340                 345                 350         


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Ser Asp Pro 
        355                 360                 365             


Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala Gly Asp 
    370                 375                 380                 


Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp Leu Pro 
385                 390                 395                 400 


Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu Pro Gln 
                405                 410                 415     


