                         SEQUENCE LISTING

<110>  Exicure, Inc.
 
<120>  LIPOSOMAL SPHERICAL NUCLEIC ACID (SNA) CONSTRUCTS FOR 
       SURVIVAL OF MOTOR NEURON (SMA) INHIBITORS

<130>  A1107.70017WO00

<140>  Not Yet Assigned
<141>  Concurrently herewith

<150>  US 62/691,585
<151>  2018-06-28

<150>  US 62/684,476
<151>  2018-06-13

<150>  US 62/664,055
<151>  2018-04-27

<150>  US 62/636,764
<151>  2018-02-28

<160>  161   

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  1
tcactttcat aatgctgg                                                     18


<210>  2
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
gctgatgctt tgggaagtat gtta                                              24


<210>  3
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
caccttcctt ctttttgatt ttgtc                                             25


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 6-FAM

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  modified by MGBNFQ

<400>  4
tacatgagtg gctatcatac tt                                                22


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
tggaccacca ataattcccc                                                   20


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
atgccagcat ttccatataa tagcc                                             25


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 6-FAM

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified by MGBNFQ

<400>  7
tacatgagtg gctatcatac t                                                 21


<210>  8

<400>  8
000

<210>  9

<400>  9
000

<210>  10
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
ctatatatag atagctttat atggatgtta aaaagcattt tgtttcacaa gacattttac       60

ttattttatt caacaaa                                                      77


<210>  11

<400>  11
000

<210>  12
<211>  28073
<212>  DNA
<213>  Homo sapiens

<400>  12
ccacaaatgt gggagggcga taaccactcg tagaaagcgt gagaagttac tacaagcggt       60

cctcccggcc accgtactgt tccgctccca gaagccccgg gcggcggaag tcgtcactct      120

taagaaggga cggggcccca cgctgcgcac ccgcgggttt gctatggcga tgagcagcgg      180

cggcagtggt ggcggcgtcc cggagcagga ggattccgtg ctgttccggc gcggcacagg      240

ccaggtgagg tcgcagccag tgcagtctcc ctattagcgc tctcagcacc cttcttccgg      300

cccaactctc cttccgcagc ctcgggacag catcaagtcg atccgctcac tggagttgtg      360

gtccgcgttt ttctacgtct tttcccactc cgttccctgc gaaccacatc cgcaagctcc      420

ttcctcgagc agtttgggct ccttgatagc gttgagtgga ggccctgccg cgacttggca      480

gtagcttatt ttgttcactc ctctctggct ggtgtggggg aggtgggggc attaggccag      540

ggtgaagcag gggaaccact taggagtctg ttaagatgat ctgaacttca gaacaagatg      600

ttattaacag agtgaaagta tttggattct gggtatattt tgaaatcgga ggcaacaggt      660

ttttcagata gattcgataa cggaggttat cctgaatagt tgaaaagata aagttgcctt      720

ttgctgaggt gggaaagaga agattgccag tagagcaggt ttctcaggag ttcagtcttg      780

ggcatagcat ggtaggggtg aatttggctg gagtgagttg gagagtagga gaagagaaat      840

ccaaggcaac atttgaccag cctgggcaac atagtgtgac tccgagtctg caaaaattag      900

acgggtgttg tggtgcgcgt ctgtggtctc agctacctgg aaggttcagg ccttggaagg      960

ctcagggagg tggaggctgc agtgatctgt gattgcgcct ctgcactcca gcctgggcga     1020

cagagccaga ccctgtctta aaacaaaata aacggccggg cgcggtggct caagcctgta     1080

atcccagcac tttgggaggc cgaggcggcc ggatcacaag gtcaggagat cgagaccatc     1140

ctggctaaca cggtgaaacc ccgtctctac tacaaataca aaaaattagc cgggcgtggt     1200

gacgggcgcc tgtagtccca gctactcggg aggctgaggc aggagaatgt catgaagccg     1260

ggaggcggag cttgcagtga gccgagatcg cgccactgca ctccagcctg ggcgatagag     1320

caagactccg tctcaaataa ataaataaat aaataaataa ataataaaaa catcggtagg     1380

catatttcaa ggaattctat ttaaaaaaaa tttttttaga gacaagttcg ctctctgtgg     1440

cccaggctgg agtacagtgg catgatccta gcccatggca gcgttgatct cttggcctca     1500

agcgaccctc ctttggagtc gctgggccta aaggagtgag ccaccacgaa attttattat     1560

aaatggaggg tagagaaatt gggcaataaa tggaggggga agtgagttaa gaggaatttt     1620

aattatgtgt gtgtggtttt aaaagagggg ggtcttgctc tgttgcccag gctgctgggg     1680

tgccagtggc gcaatcatga atcactacag ccttggactc ctggcctcaa gctatcctcc     1740

cacctctgcc tcccaaagta ctgggattac tagtgtgagc cactgcacta agataggagc     1800

aacatgtttc agcatgtttg tgggttgata ggaaagatga gaatgggaaa gttgatgtcg     1860

gaaagaagac aatggctaga gcaatgtcct agagtaggta agaagggatg gatttggcct     1920

ttgttggaaa cattagcggt tcttttggtg acagctatat agttaacaca tctatgatac     1980

gtgaatgggc agataggatg gcaggagatt ttgaaagttc tcttgattct tactgttctc     2040

ttagtgaaag aagcaaggtt atcagctaga agctgggatg ggagaggaaa gagaagatgg     2100

gaagtagata gttctttaga agagtgggca agggttggac tagggaagtt tagtggaaat     2160

attgctaggc aacataaaga gcctacttga gattcgtggt catgagttga aggagaccag     2220

acagcaagat tgtgtatgag ggcacccaca gagtaaatgg agagttgaaa ttaatgcagt     2280

tgtgatttta ccacgtggat atgaagaagt gagggggaga agtacaaagg agttctctta     2340

atgattgacc atggaattta agctggctaa gaaaggaagt gagaggccgg gcgcggtggc     2400

tcacgcctgt aatcccagca ctttgggaga ctgaggtggg tggattacct gaggtcagga     2460

gtttgagacc aacctggccg atatggcgaa accccatctc taataaaaat acagaaaaat     2520

tagccgggaa tggtggcagg tgcctgtaat cccagctact caagaggctg tggcaggagt     2580

atcccttgga cccaggaggt ggaggttgca gtgagccgag atcacgccac tgtactccag     2640

cctggacgat atagtgagac ttcacctcaa aaaaaaaaaa aaagaaagga agtgaggatt     2700

ttaagaccct gagagacagt ttaaaaagtg ggaggatcgg ccgggcgctg tggctgacac     2760

ctgtaatccc agcactttgg gaggccgagt tgggcagatc acaaggtcag gagttcgaga     2820

ccagcctggc caatatggtg aaaccttgtc tctactaaaa atacaaaaat tagccgggca     2880

tggtgtcacg tgtctataat cccagctact cgggaggctg aggcagaaaa attgcttgaa     2940

cctgggaggc agaggttgca gacagctgag atcactccat tgcactccag cctgggcaac     3000

aagagcaaaa ctttgtcttt aaaaaaaaaa aaaaaaaaag aatacaaaaa ttagccgggc     3060

gtggtggcgc gtgcctataa tcccagctac ttgggaggct gaggcaggag aatcagttga     3120

acacgggagg cgaggtttgc agtgagccga gattgcgcca ctgcactcca gcctgggcga     3180

cagagcagga ctcctcttgg aaaaaaaaaa ttagctgggc atggtggcag gtgcctgtag     3240

tctcagctac tagggaggct gaggcaggaa aatcacttga acccgggatg tggagtttgc     3300

agtgacccga gatcgtgcca ctgtactcca tcctgggcga caaaatgaga ctctgcctca     3360

aaaaaaaaaa aaaaaaaaag tgggaggatc aatgtactgc cagtcctaat gaagtggaat     3420

gattgtcccc atcaaatcac tagtaggagt aagttgcaga gcctagaagg tgatggttaa     3480

gagagtggga ttcttgaaac tgcatttatg gagaggttgt ggttattggt tataataaat     3540

aaatacagtt gaagtgagtg agtagctgag atttggggat gtatcagttc attcttacac     3600

tgctacaaag acatacctga gaccaggtat ttataaagat aagaggttta atcagctcac     3660

agttctgctg cctgtacagg cttctcttgt ggaggcctaa ggaaacttac agtcatggtg     3720

gaaggtgaag gggaaacaag cacagtcttc acatggccag caggagagag agagaagggg     3780

gaagtgctac atactttaaa acaaccagat cttgtgagaa cgcttatcag gaaacagcac     3840

ttggggatgg tgctaaatca ttagaaatca cccccatgat ccagtcgcct cctaccatgc     3900

ccacctccaa cactggggat cacaattcag catgagattt gggtaggaac acagagctgc     3960

accacatcag aggatgtaca agattgtggt ggagaggagt ttagagacct gcaaatatag     4020

ggtaattgaa gggatcatct acatggatat ttaaatcacc aaaaattatg acaggagtag     4080

tgttggagag agaactgcga tgtaaacatt aaggaatgag gaagagtgac tcggtaggct     4140

gtaggtgact gcaataggaa acgataatag actgtgagtc tggtgacaag attttccttc     4200

tttctttttt tccccccccc cgagacaggg cctctttttg ttgcccaggt gggagtgcag     4260

tggcgcgatc acggctcact acaacctcct cccaagctca agggattctc ccacttcagc     4320

ctctcaagta gctggaacta caggtgctga ccaccatgcc tggctacttt ttgtcaggat     4380

tttcaaggct gggaattttg agaggggaat ggaggagaat aatctgaaag tgcaagtaag     4440

gagcagggaa gatttctttt ttcttttttt tttttttttt tgagtcggag tctggctcag     4500

tcgcccaggc tggagtgcag tggcgagatc tccgctcact gcaagctccg cctcccgtgt     4560

tcacgccatt ctcctccttc agcctcccga gtagctggga ctacaggcgc ccgccaccac     4620

gcccagctaa ttgttttttt gtatttttag tagagacggg gtttcaccgt gttagccagg     4680

atggtctcaa tctcctgact ttgtgatccg cccaccccgg cctcccaaag cgcttgggat     4740

tacaggcgtg agccaccgcg ccagccagag cagggaagat ttcttcccca catctccagt     4800

aggtacagtg atatgaagtg tgtggaggag aaaagaggaa acatctatca tttgagatgg     4860

ctgcgaaagg aaaaggcatc ctcagggagc tagattttac ttagagcaag aaatgaaggg     4920

atgattcaga ggttaaaaga gtggatttta tgaattactc aagggagcac agtggaagtt     4980

tcaggaagtg gtaggagaag gtagaagatg gcagggtgtt gggaataatt tgagaaatct     5040

gagctactgg aaatgactga gaatcagata taaaggcagt cctggtggtc cgttctggct     5100

gccgttgctg tgtaacgaat ctgccaaaac ttagtggctt gaaacaacaa agaacatttt     5160

attatctctc attgtttctg tgggttagga atttgtgaga gccgtgctgg gcagttttcg     5220

tgcggctgtc tcgtggttgc acctacatag ttgctagagc tacagtagct ggggactgag     5280

cagctaggga ttggcaggct atctcttttt ttcatgtagt ctcatgaaga tttctttatg     5340

tggtttcaat gtgtgggctg gtttggattt ccttatagca tggtggcctc agttggattg     5400

ctgttttgtg atccttttca tccctccttg tcctgtcccc agacaaccac tgatctactt     5460

tctgtcacca tagattagcc tgcattttta agaattttta taaacgtgga atgatagagt     5520

accttttttg tcacgtttct tttatttatc atagctattt tgattttcat ccattttatt     5580

gctgagtagt atcccattgc atgtatatac tatactgtat tcattcgctt gcttgtgaac     5640

atttgggctt tttccagttt gggactgtta acaagtagag ccactatgaa tattagtgta     5700

taagacttca tatagccaag gctggcagat cgcttgagcc caggagtttg agaccagcct     5760

gggaaacatg gtgaaacctc tatttttatt ttaaaatcaa aaattaaaaa ttttctataa     5820

aaaattttaa agaagacttt gtatagacat acgctttcat ttttcttgag tgaatactta     5880

ggtctcaggg tagatgtatt ttaagtcttt aaggagctgt caaactcttc ctcaaagtgg     5940

tggttgtacc atgttacttt ttaatataac agagattaat tgagcaaaga aaaattcaaa     6000

agttggacag cccccacaac taaataggtt cagaacagct cccccatttt gcattttgac     6060

cagcaatgta tgaaagttcc atttgctcag tgtccctgca aacacctggt atggtcagtc     6120

tttttaattt taggcattat aatagatata gtggcttctt gtgattttaa ttagcatttc     6180

ctaatgacca gtgctgctgt tgatcatttc atgagtgtat ttgccatccg tatatctttt     6240

ttggtgaagt gtctattcaa atcatttggg tttttttttt ttttgttttt tttttttgga     6300

gacagtgtct cactctgtca cccaggctgt tgtgcagtgg tgcaatcaca cagcctactg     6360

cagcctccac ctcctgcgct cagtcttctt gtctcagcct tctgagtagc tgaaattacg     6420

agcacacgcc acaatgcctg gctaattttt taaaattttg tagaaacaag gtctcattat     6480

gttgcctggg cttgtcgtga actcctgggc tcaagcaatc ttcctgcctc agcctcccaa     6540

agattgggat tgcaagtatg agccactgca cccggccaac ttacccatct tttaattgaa     6600

tttttttgtt gttgaggttt gagagttctt catgtttgct gggtacaata tctttatcag     6660

ataggtaact tgcatgtatt ttctcccggt ttacactttg gtttttcatt ttgttaacaa     6720

cgtcttttta agaacagaaa atcttaattt tgctgaaatc taatttttca gttttttctt     6780

tgatggtttt gagagaggag gtaaaaaaag actaggtaag ccgatagtta gacagagtcc     6840

tcggtagaac ttcccttcta acaaaaagca gcccaagaaa tcacttctct tctaacaagg     6900

agcagcctgg aagatcgggc tgtaaacatg tataaggaag cagctctggc acagaggggg     6960

agcttcctgg gtaatcagca agcttcacat acgtaaggtg ggtatgtgaa gtaaacacag     7020

tatgtgaagt aaacacagtg gaccttagta catactcaga taaggaagct ggaagcttgc     7080

atgttgtgag ttgttggggt tgcctgcagc tgcacggaga gaaaggggta cctggggcca     7140

ggcatgtcca ccatggtggc tccacctccc cttatttagc acatgcacaa taggaaagag     7200

ataagcaatg tggagtagct caggccaagg acctgcctgc ataataaaag gttggggtgg     7260

gggatgccag agattcacgc tctgtgcaga tggcaacacc tggtcctaac tggttttttg     7320

ctccctatgt gtagataagc tacccccttc ccattagctc atttataaaa atgcttgcat     7380

ttcactgtgg aatgggaact cttttcagga cctctctctg caggagagag ctagtctctt     7440

tcttttgcct attaaacttc tgctctagcc tcacaccctt ggtgtgtcag cgtccttgat     7500

ttcctcagcg tgagaccaag aacctcgggt gccaccccag gcaacaaggc catttcagtt     7560

tgttcttttg ttataggcaa tccatgatca cagatttttc tctctttttt ttttttacac     7620

agtttagagt tttagtttta cacttaggtc tgtaatccat tttgtattaa ttcttatatg     7680

tggctcagtg taggtggaaa tttggtttgt ttttgcataa ggatttccaa tagttttacc     7740

accatttctt gaaactacta tgctttctct attaaaccac atttgtaact ttagttaaaa     7800

tcagtcacat atatcacagg gctatttctg actctcaatt ctgttacatt gtctattagt     7860

gtatattgat gtcagtacta cacttttaat tactattgct tcagggtatg tcttgtaaac     7920

caaaaataaa attataggcc ccccccgccc ctgcacaacc aactgaatgg acccatcctc     7980

tcagccaagg gcattccaaa attaacctga aaaactagtt caagccatga tgggaagggg     8040

gagttggaca tgtctcatca caccctacta ccttttggaa ttactgatag aacagactct     8100

taaagtctga aaagaaacat ttacaaccta ccctctctga agcctgctac ctgggagctt     8160

catctgcatg ataaaacctt ggtctccaca accccttatg gtaacccaaa cattcctttc     8220

tgttgataat aactctttca actagttgcc aattagaaaa tctttaaatc ttcctatgac     8280

ctagaaacct ccctaccccc actttgagtt gtcctgcctt tcctgacaga actcatgtac     8340

atcttacata tattgattga tgcctcatgt ctccctaaaa tgtataaaac aaagctgtac     8400

cccaccacct tggggacatg tcatcaggac ctcctgtggc tgtgtcatag gagcgtcttt     8460

aactttggca aaataaactt tctaaattga ttgaaacctg tcttagctac ttctggttta     8520

cagtcttaaa gttagataat gtaaattgtc cagctttggt ttatttttgt ccttagtagt     8580

tccatataaa ttttagaatc agcttttcaa tttaatacac tactttcctc ttagatccac     8640

aattaaatat atttgatgct aacaattctg ttttatgttt ttcgtttttt ttttttgaga     8700

caagagtttc gctcttgttg cccaggctgg agtgcagtgg cgcgatcttg gctcaccaca     8760

acctccacct cccaggttca agcaattctt ctgcctcagc ctcccgagta gctgggatta     8820

caggcatgcg ccaccacgcc cggctaattt tgtattttta gtagagacgg ggtttcacca     8880

tgttgatcag gctggtcttg aactcctgac ctcaggtgat ccacccacct cggcctccca     8940

aagtgttggg attacaggcg tgaaccacca tgcctggcca gttctgttat ttttaaaacc     9000

caagtttccc tggtcatatc ttggttggat gaagcgtatt ttcaatagat taccctggaa     9060

aggctagtga gtacggtatt cttctacatt ttagactttt cttagtcttg ctacttcaag     9120

gacagctagg ctgcatataa aattcttggc tcatactttt tccccataaa tttctatgag     9180

aaagtctaat gataactgat tttctttatt ttgtaactta gtctttttgc ttagaggctc     9240

tctgaggatg ggagggggtt cttcctccca tccctaggaa tttttctttt ttttaaattc     9300

ctaatcacta gaccaccagg aagattgttt gttttgtttt gtttttattc ttcagggacc     9360

ccatttatac atacgttaaa taaatactgt ttgccaatgt atcaaccatt ttgcttctta     9420

tttatttttg ttcctttggt tctttttcat ggctttgctt tggtgctcct tagattttca     9480

gtcagatgta tttgtccttg ggtaccttgt aatcagtatt accttttctt ctgtcgcttt     9540

gttttctgtt cgttttgaaa ttacttgttt cctggtctgg caataacagt tgagatatga     9600

ggagtttgag ctgccatctg tctatgtatc ttgctttaag actgcactct tctattgata     9660

tcactggcct tgattttgtg atttctttat ttcttcagga ccacccttca ttttctactg     9720

tttgcttcct ttttttttga gatggagtct cactctgtca ctcaggctgg agtgcagtga     9780

tcttggctca ttgcaacctc tgcctcccgg gttccagcaa ttctcctgcc tcagcctccc     9840

aagtatctgg gactacaggt gtgcaccacc atgcccggct aagttttgta tttttaatag     9900

agacggggtt ttgccacatt ggcaggctgg tctcaaactc ctgatgtcaa gtgatccacc     9960

caccccaccc acctctgcat cccaaagtgc tgggattaca ggaatgagct gccgtgccca    10020

gcctcccccc tacccccctt tttttctttc gagacagaga ttataggtgt gagccactgg    10080

acccagcctg tttttattcc ttttaccaaa tctccaagga atatcttccc ttccaagtgc    10140

gaatgtaacc ttaagtcagt taacctcttt gtgattactt ttcttatctg caaagtgact    10200

taatgatctt aagtactttt tttttttgag acagggtctc actgtcaccc tggctggagt    10260

gcagtggcac gatctctgat ctccactcac tgcaatctcc tcttccctgg ttcaagcggc    10320

cctcccacct tagccttctg ggtagctggg actacagatg tgaaccacca cgcccagcta    10380

atttttgtac tttttgtaga gatggggttt tgccatgttg cccaggctgg gattattaag    10440

tactttttat catacagcaa gattgacatt ttatattgga atacatttgt ctctatataa    10500

cggagattaa caggaaaatg acaagcctgg gtgcggtggc tcatgcctgt aatcccagca    10560

ctttgggagg ctgaggtggg aggatcactt gaggtcagga gttcgagacc agttttgcca    10620

agatgatgaa agcccatgtc tactaaaaat acaaaaatta gcccagcttg atggtgggcg    10680

cctataatcc cagctatttg agagactgag gcaggagaat cacttgaacc tgggcagcag    10740

aggttgcagt gagccgagat catgccactg cactccagcc tgggtggcat agcgagactc    10800

ttgtctcaag agaaaacaaa acaaaacaaa aaaaaaacag gaaaatgaca aaaagtaata    10860

ttacaactca gtgaatttta taacaaactt ttttggaatt cattgactaa tactatacca    10920

aatccaaaat actctctagt ataccaaatc caactctacc ctatagtata aattggattc    10980

tatttggact tgtctcacta atccctcata cagtgtgttt tattttttat tgaagtaaaa    11040

aaatttgtca ttttaaccat ttttaagtat atagttcagt aatattaagt atgttcatgt    11100

tgttgcgcaa tagatcttcg gaagtttttc gtcttgcaac ctgaaactct acccattagc    11160

aaattcccat ttctccttac acttagccct tggtaatcat cattcttttt tttttttttt    11220

tgagatggag ttttactctt gttgcccagg ctggagtgca atggtgcaat ctcgactcac    11280

cacaacctcc gcctcccagg ttcaagcaat tctacctcag cctcccgagt agctgggatt    11340

acagtcatgc accaccacgc ccggctaatt ttgtattttt agtagagaag gggtttctcc    11400

atgttgaggc tggtctcgaa ctcctgacct caggtgatct gcccacctcg gcctcccaaa    11460

gtgctgggat tacaggcgtg agccactgcg cctggcccat tctttctaat tctataaatt    11520

tgactactta gttaccttac ataaataaat tcttatagtt agtgttattt ttgcttccat    11580

gccttttttg ttgttgttca tgctcttact tggaatgcgt tctattttgt ctacctatgc    11640

acatcctgtt gggttttttt tttttttggg ggtttttttt gttttttttt gttttttttt    11700

cccagacaag gtctcaattt gttacccagg ctggagtgca gcggcgccat ctccactcac    11760

tgcatcctca acttcctggg cccaggtgat cctctcgcct cagcccctgc aggtagctgg    11820

gactataggc atgtgccacc atgcccagct aaatttggtt tttttgtttg tttgtttttg    11880

agacagagtc tcactctgtc acccaggctg gagtgcagtg gcacaatctc agctcactgc    11940

aatctctgcc gcccgggttc aagtgattct cctgcctcag cctcccaagc agctgggatt    12000

acaggtgact gccaccacgc cagctaagtt ttgtagtttt agtagagatg gggtttcacc    12060

ttgttggcca tgctggtctc gaactcctga cctcgtgatc tgcctgcttc tgcctcccaa    12120

agtgctggaa ttacaggcat gagccaccac gcccggccag aatttttgta tttttagtag    12180

acacaaggtt cttaccctgt tgcctaggct ggtctggaag tcctggactc aagcaattca    12240

cctgccttgg cctcccaaaa tgctgggatt acaagccacc atgcccggcc taaatcctgt    12300

tgttttgttt tgttttattt tgttttgttt tgttttgttt gttttttgag acagagtctc    12360

gctatgtctc tcaggctgta gtgcagtggc gcgatcttgg ctcactgcca cctctgcctc    12420

ccaggttcaa gtgattctcc tgcctcagcc tcccaagtag ctgggattac aggcatgtgc    12480

tactatgtcc ggctaatttt tgtattttta gtagagacag ggtttcacca tgttggccag    12540

gctggtctcg aactcctgac ctcgtgatcc acccacctcg gccacccaaa gtgctgggat    12600

tacaggcgtg agtggttttt atttcttagg ccggtttcct ccatatgatc ttgcagtaga    12660

cattaatttc tttccttttt aattaaaata ctgtttgtat ttcacatttt gatgtttgtt    12720

aagatttgtt ttatattgtt ttttgttttg tcttgtgtga tagtcttaaa tccctagtta    12780

gataataact ggagagtacc atgtttctat atatctctca gtgacttgca cagtgctagc    12840

agatagtgct aaaaaattat ttattattat tattattttg ttattgttgt tgttgttgtt    12900

agacagggtc ttcctctgtc acccaggcta gagggcaatg ggatgatcat agcttactgc    12960

agcctccaac aactgggctc atgtaattct cctgcctcag cttcccaagt agctgggatt    13020

acaggcatga gccaccatgt ctggacaaaa atatttccag gtgcagtggc tcatgcctgt    13080

aattcccaca cttgggaggc cgagcgaggc tggaggatca cttgagccta ggagttcaag    13140

accagcttgg ctaagatggc gagaccccgt ccctacaaaa aattttaaaa actagccagg    13200

catggtggca tgcacctata ttcccaacta ctcagtgggc tgaggtggga gggtcatttg    13260

aacacaggaa tttgagggga gaaaaaaaga agagagaaag agaagtgaag gaaggaagaa    13320

aggaaggagg gagggagaga agaaagaaac gaaagaaagg aaaagaaaag gaaggaaaga    13380

aaattggtac caggaaagca ggaaagggaa atggaagtaa aaaaataata ataataataa    13440

aatgaaaatt ggttagtcac tattaacaat ttgtatcctt ataatctgga aacattataa    13500

tttcaaaaga aaaaatattc tttggatcat aggttctgag gtcagaacag cattcccgta    13560

gtctagatga agtcaagttt tatctgatct taattgaaat aaatatagct ggccttgaac    13620

aaatctactc atggtatgtg gataggaatt aaattgtagg ggcattcact tgatggcatt    13680

cattcttaga acatttacct atgtctagct tttggagtaa agtcacataa cctctaacca    13740

ggtaagtttc ctgtggcttt atttaggatt ttaaatactc attttcagtg taattttgtt    13800

atgtgtggat taagatgact cttggtacta acatacattt tctgattaaa cctatctgaa    13860

catgagttgt ttttatttct taccctttcc agagcgatga ttctgacatt tgggatgata    13920

cagcactgat aaaagcatat gataaagctg tggcttcatt taaggtatga aatgcttgct    13980

tagtcgtttt cttattttct cgttattcat ttggaaagga attgataaca tacgataaag    14040

tgttaaagta catgttattc agttttcatt ttgaagatta gatggtagta tgagttagtt    14100

aaatcaggtg atatcctcct ttagaagttg atagcctata tatgtcatcc tttgtggagg    14160

caatttaaat aaaatttaaa acatttattc ctggctgggt atggtggctc actcctgtaa    14220

tcccagcact ttgagaggct gaggcgggtg gatcacctga ggtcaggagt ttgagaccag    14280

cctggccaac atggtgaaac cccgtcttta ctaaaaatac aaaaattagc caagcatggt    14340

ggcacgtgcc tgtaatccca gctgcttggg acactgaggc aggagaattg cttgaacctg    14400

gggggcagag gttgcaatga ttgcaccact gcactccagc ctgggcgata gagtgagact    14460

ccatctcaga aaacgaacaa acaatgtatt ccttttagta tttttacatt gtatcaaact    14520

atggaagtcc tctaattgag attaataaga aaaagacaat ctgaattata attttaaaca    14580

tttaacaagc atgtagtaaa ataatgatga agataaatag cattagtaca gcaattaata    14640

tttgtagcat gctgacagtg ctctgtgtgc gtttcatata ttaaattact ctaatcatcc    14700

caaatcctgt aagttgggta tcaattcaag tgttcctatt gggtaggaat atacagttct    14760

tttaggaaat gtagtatggt tctgtgtctc aaacaggaca cttacacagt tggccaacat    14820

catcaccttc tccattctct gagatgttta gtcttactga gcactaaata tgggtcatca    14880

atagtccaga ctaccttgag caaacaatag tccagactac cttgagcaaa cagagcatat    14940

actcatacag tgtataaaga gcaccaagca tacagatttc atgtctttct catagttact    15000

cttgtaacat gagctaaaga tcagacctct atgtcacctt tgtaactgat ttctagattt    15060

tttttttttt ttgagatggg gtcttgccct gtcacccagg ctggagtgta gtggcgtgat    15120

catgcctcat tggagccttc aactcatgag ctcaaacaat cctcctacct cagcttcctg    15180

agtagttggg accacaggtg tgtgccacca cacccagctc atttttgtat tctttgtaga    15240

gatgcagtct caccctgttg cccacgctgg cctggaactc ctgagctcaa aagatccctc    15300

cgccttgacc ttccaaagtg ctgggattac aagcatgaac cactgcaccc ggcctagatt    15360

tttaaatgtg ctttccagta tacactgaaa ctagaagtcg actaaagaat taccaagaga    15420

attctataaa atagagattg aaatggggct cgatgtggga tgggttggtg atattgcagg    15480

gagaagtaat ctgagtaaag gaggaaaaga actgatttgg gaaaacgata gttttagtag    15540

tgagtttgag tatgaattaa gttgagattg aatttgaatt aagttgaggt tgaatatgaa    15600

ttaagttgag gttgagtttg aggtatgaat taagatgtga aattgatcat tggaaatgtt    15660

agattgagaa aagtcacagc tggattaata gcttcagaag tgtgtttgca gacagttgca    15720

actaaagtaa taagaataga tggccttggc cgggcgcggt ggctcacgcc tgtaatccca    15780

gtactttggg aggctgaggc gagcaaatca cgaggtcagg agttcaagac cagcctggcc    15840

cacatggtga aaccccgtct ttattaaaaa tacaaaaatt agctgtgcac agtggtgcac    15900

gcctgtaatc ccagctactc gggaggctga gacaggagaa tcgcttgaac ctgggaggtg    15960

gaggttgcag tgagctgaga tcagtgtgac tgcactccag cccggtgaca gagtgagact    16020

ctgtgtaaaa aaataaaata aataaaataa tggccgtaag caagtaaaga aggatggcca    16080

gctcttattg ggaatgccta aatctaaggc ttgatcagaa gtaatgaaac cgttggggcc    16140

ctacattgct atgacatcca aagggccatg aatatcagga agaaagataa ttaacagggt    16200

ctaatgttac agagaggttg agagcaagga gatttgatta aaagggtctt tagagctgat    16260

gtcaggtgta tgatgccttt aagagcagtt tttatagtgc agggggtggt caaaagagaa    16320

aataggtgct ttctgaggtg acggagcctt gagactagct tatagtagta actgggttat    16380

gtcgtgactt ttattctgtg caccaccctg taacatgtac atttttattc ctattttcgt    16440

agcatgctct aaagaatggt gacatttgtg aaacttcggg taaaccaaaa accacaccta    16500

aaagaaaacc tgctaagaag aataaaagcc aaaagaagaa tactgcagct tccttacaac    16560

aggttatttt aaaatgttga gatttaactt caaaggatgt ctcattagtc cttatttaat    16620

agtgtaaaat gtctttaact taagtgatta gtacagtgtt tctattgaca tatacttata    16680

caacttcaaa aacaactatt aaattttctg ttatttagga acatgcatat tagtcatgaa    16740

agtataaaga attagatggg aatgataaat gctaaaatca ggacatgtgt tccatttgtg    16800

aatggaaggc agggagaagg tgccgtttgg aaggagtacc caagagccgt aagctgaatt    16860

ggcagtgttt tacatcttaa gctgagagat agattttttt ttcccctttt tctttaaaaa    16920

ctctaaaact gttaattcca aggaacccag aagtctaggt agattatttc tgctagttaa    16980

aagcagtagt cctgaaagct gaatattttg gtgtcttttg agccaacttt agtttcatca    17040

ttaccaaggg ggaagagagc taacagttga tgagcacttg ctctaggcca gtccagagtg    17100

ctgggcacca tacgcatttt atctccctcc cgctattcac aacaaatatg ggaggtagtt    17160

tatattatag ccatctaata agatggggaa actaagactc aaagagattc agaaacttgt    17220

ccatgattat aaatgtaaga gagttggaat tcagatttat gtatttagac cccaagcctt    17280

tctcattaca tcattttgcc ttccaaatct ctaccctcta tccttcacct ccccactgat    17340

caaaacgaga tgatagtttg ccctcttcaa aagaaatgtg tgcatgtata tatctttgat    17400

ttcttttgta gtggaaagtt ggggacaaat gttctgccat ttggtcagaa gacggttgca    17460

tttacccagc taccattgct tcaattgatt ttaagagaga aacctgtgtt gtggtttaca    17520

ctggatatgg aaatagagag gagcaaaatc tgtccgatct actttcccca atctgtgaag    17580

tagctaataa tatagaacaa aatgctcaag aggtaaggat acaaaaaaaa aaaaattcaa    17640

tttctggaag cagagactag atgagaaact gttaaacagt atacacagtt gtcagtttga    17700

tccaccgagg cattaatttt ttcttaatca cacccttata acaaaaacct gcatattttt    17760

tctttttaaa gaatgaaaat gaaagccaag tttcaacaga tgaaagtgag aactccaggt    17820

ctcctggaaa taaatcagat aacatcaagc ccaaatctgc tccatggaac tcttttctcc    17880

ctccaccacc ccccatgcca gggccaagac tgggaccagg aaaggtaaac cttctatgaa    17940

agttttccag aaaatagtta atgtcgggac atttaacctc tctgttaact aatttgtagc    18000

tctcccatga aacttttgta gcttaaatac acaagaattt tttgaaaagg aaataagata    18060

atgatgcaaa atagttaatt ttttaaaaaa atgttagaca ctgcagtgga tgcaacaaaa    18120

tactttatat gaaagattta tccagttaac ttttgtggag tattaggtat tagactaata    18180

attagcacac ttacttaagt tagaaagtat aataatgcgc cggacgcggt agctcacgcc    18240

tgtaatccca gcactttggg aggccaaggt gggcggatca caaggtcagg agatcgagac    18300

catcctggct aacacggtga aaccccatct ctactgaaaa tacaaaaaaa tttgccgggc    18360

gtgatggcgg gcacctgtag tcccagctac tcgggaggct gaggcaggag gatggtgtga    18420

accccggagg cagagcttgc agtgagtcaa gatcgtgcca ctgcactcca acctgggcga    18480

cagaatgaga ctccatctca aacaaaaaaa caaaacaaaa caaaaaaaag tgtaataata    18540

atttatcatt agctggatga tatgctgttg tttcccatgt cacctgtata agatatgtaa    18600

aataagaaca cattatttac atctaatata gataaaatcc tgaggcgctc tcagattgtt    18660

ttgtagagtt caaatgtaaa tattgttttc atttatggtc cttttggtta taagtaacag    18720

aaatcaactc taaaaagatt tttattatag gttagattat gtcatggaac cttaaggctt    18780

gtccctttct agttcttttg tgtaaagcgg tgatttcttc catggaggga atggtattta    18840

ggcaattttt tttttttttt cgagatggag tcttgctctg tcgctcaggc tggagtgcag    18900

tggcaccatt tcagctcact gcaacttcca cctcctgggt tcaagtgatt ctcctgcttc    18960

agcctcccaa gtagctgaga ttacaggcac ccgccaccac acccggctta ttttgtattt    19020

ttagtagaga tggggtttca ccatgttggc caggctggtc ttgaactcct gacctcaagt    19080

gatctcccca ccttggcctt ccaaagtgct aggattacag gcgcctagcc taggcagtca    19140

ttttcaaaaa acaagcatga ctcaccaaaa gttttaagat tttctgtgat aatgttctta    19200

ttgaggctta cattatatta cagtttcttg aatctaaaat gatgtaccct cttagaatat    19260

atacatcatg cttcattggt ctcagggggc tgatttttat aaggagagat ttgctagttt    19320

tcacaatatg tcctctaagt tggcatgtat agctaaacag gctttcataa aaatatacaa    19380

tttagttaat gaaatttggg atatagtctt ttatgattga aataattttg ctaaatagac    19440

tgtctctgat ttattaggta atcaccactc ttattttgtt ttacttcctt aatgtctaca    19500

tagaaaggaa atgagaaaaa tccagaggtt gtcatttgac ttatgagtct gtttgacttc    19560

aggatttggt acatgaaatt tcacttaatc tttttgatat gtataaaaca aatattctgg    19620

gtaattattt ttatcctttt ggttttgagt cctttttatt cctatcatat tgaaattggt    19680

aagttaattt tcctttgaaa tattccttat agccaggtct aaaattcaat ggcccaccac    19740

cgccaccgcc accaccacca ccccacttac tatcatgctg gctgcctcca tttccttctg    19800

gaccaccagt aagtaaaaaa gagtataggt tagattttgc tttcacatac aatttgataa    19860

ttagcagaat agaggattgt aaaatgtcat tgtagaacat cccttgggcc agattctaat    19920

gggtagaaat ttgaactaaa cctctgggtt ttgtttgttt ttaatgcctt tctgttaccc    19980

agatgcagtg ctcttgtagt cccaagtcta agctctaggt tgccttcttt cctggcagaa    20040

gttggtgtct atgccataag gaggtagttc ctgttagaag ggatttaatt ataccttata    20100

taaggaatta gtgtttgccc ttctaggtat agttggatgt tagcttctga tgtaaactgg    20160

atttcttttt ctttctctct cttttttttt ttttgttttg gaggcagagt tttgcccttg    20220

taccccaggc tggagtgcag tggtgtgatc tcagctcaca gcaacctccg cctcctgggt    20280

tcaagcaatt ctgcctcggc ctcccaagta gctgggatta caggcgactg ccaccacacc    20340

cggctaattt ttgttttatt agtagagatg gggtttcacc atgttggcca gactgatctt    20400

gaactcctga cctcaggtga tccacccgcc ttggcctccc aaagcgctgg gattacaggc    20460

gtgagctgcc gcacccagct gtaaactgga tttctaatgg tagattttta ggtattaaca    20520

atagataaaa agatactttt tggcatactg tgtattggga tggggttaga acaggtgttc    20580

tacccaagac atttacttaa aatcgccctc gaaatgctat gtgagctgtg tgtgtgtgtg    20640

tgtgtgtgtg tgtattaagg aaaagcatga aagtatttat gcttgatttt ttttttttac    20700

tcatagcttc atagtggaac agatacatag tctaaatcaa aatgtttaaa ctttttatgt    20760

cacttgctgt cttttcgtcc tcgttaaatt taattttgtt ggtcttttgt tgttattggt    20820

tggttttctc caaatgctag ctatgttaag aaatttaagg ccaggtacag tggctcatgc    20880

ctgtaatccc ggcattttag aaggctgagg caggaggatc acttgagctc aggagtttga    20940

gaccagtctg ggcaacatag caagacctcg tctttgttta ggggaaaaaa aagaaattta    21000

agtaggagat tatataagca aaaatacaat taatttccag cattcactat ataatataaa    21060

tctccagact ttactttttt gtttactgga tataaacaat atctttttct gtctccagat    21120

aattccccca ccacctccca tatgtccaga ttctcttgat gatgctgatg ctttgggaag    21180

tatgttaatt tcatggtaca tgagtggcta tcatactggc tattatatgg taagtaatca    21240

ctcagcatct tttcctgaca atttttttgt agttatgtga ctttgttttg taaatttata    21300

aaatactact tgcttctctc tttatattac taaaaaataa aaataaaaaa atacaactgt    21360

ctgaggctta aattactctt gcattgtccc taagtataat tttagttaat tttaaaaagc    21420

tttcatgcta ttgttagatt attttgatta tacacttttg aattgaaatt atactttttc    21480

taaataatgt tttaatctct gatttgaaat tgattgtagg gaatggaaaa gatgggataa    21540

tttttcataa atgaaaaatg aaattctttt tttttttttt ttttttttga gacggagtct    21600

tgctctgttg cccaggctgg agtgcaatgg cgtgatcttg gctcacagca agctctgcct    21660

cctggattca cgccattctc ctgcctcagc ctcagaggta gctgggacta caggtgcctg    21720

ccaccacgcc tgtctaattt tttgtatttt tttgtaaaga cagggtttca ctgtgttagc    21780

caggatggtc tcaatctcct gaccccgtga tccacccgcc tcggccttcc aagagaaatg    21840

aaattttttt aatgcacaaa gatctggggt aatgtgtacc acattgaacc ttggggagta    21900

tggcttcaaa cttgtcactt tatacgttag tctcctacgg acatgttcta ttgtatttta    21960

gtcagaacat ttaaaattat tttattttat tttatttttt tttttttttt gagacggagt    22020

ctcgctctgt cacccaggct ggagtacagt ggcgcagtct cggctcactg caagctccgc    22080

ctcccgggtt cacgccattc tcctgcctca gcctctccga gtagctggga ctacaggcgc    22140

ccgccaccac gcccggctaa ttttttttta tttttagtag agacggggtt tcaccgtggt    22200

ctcgatctcc tgacctcgtg atccacccgc ctcggcctcc caaagtgctg ggattacaag    22260

cgtgagccac cgcgcccggc ctaaaattat ttttaaaagt aagctcttgt gccctgctaa    22320

aattatgatg tgatattgta ggcacttgta tttttagtaa attaatatag aagaaacaac    22380

tgacttaaag gtgtatgttt ttaaatgtat catctgtgtg tgcccccatt aatattctta    22440

tttaaaagtt aaggccagac atggtggctt acaactgtaa tcccaacagt ttgtgaggcc    22500

gaggcaggca gatcacttga ggtcaggagt ttgagaccag cctggccaac atgatgaaac    22560

cttgtctcta ctaaaaatac caaaaaaaat ttagccaggc atggtggcac atgcctgtaa    22620

tccgagctac ttgggaggct gtggcaggaa aattgcttta atctgggagg cagaggttgc    22680

agtgagttga gattgtgcca ctgcactcca cccttggtga cagagtgaga ttccatctca    22740

aaaaaagaaa aaggcctggc acggtggctc acacctataa tcccagtact ttgggaggta    22800

gaggcaggtg gatcacttga ggttaggagt tcaggaccag cctggccaac atggtgacta    22860

ctccatttct actaaataca caaaacttag cccagtggcg ggcagttgta atcccagcta    22920

cttgagaggt tgaggcagga gaatcacttg aacctgggag gcagaggttg cagtgagccg    22980

agatcacacc gctgcactct agcctggcca acagagtgag aatttgcgga gggaaaaaaa    23040

agtcacgctt cagttgttgt agtataacct tggtatattg tatgtatcat gaattcctca    23100

ttttaatgac caaaaagtaa taaatcaaca gcttgtaatt tgttttgaga tcagttatct    23160

gactgtaaca ctgtaggctt ttgtgttttt taaattatga aatatttgaa aaaaatacat    23220

aatgtatata taaagtattg gtataattta tgttctaaat aactttcttg agaaataatt    23280

cacatggtgt gcagtttacc tttgaaagta tacaagttgg ctgggcacaa tggctcacgc    23340

ctgtaatccc agcactttgg gaggccaggg caggtggatc acgaggtcag gagatcgaga    23400

ccatcctggc taacatggtg aaaccccgtc tctactaaaa gtacaaaaac aaattagccg    23460

ggcatgttgg cgggcacctt ttgtcccagc tgctcgggag gctgaggcag gagagtggcg    23520

tgaacccagg aggtggagct tgcagtgagc cgagattgtg ccagtgcact ccagcctggg    23580

cgacagagcg agactctgtc tcaaaaaata aaataaaaaa gaaagtatac aagtcagtgg    23640

ttttggtttt cagttatgca accatcacta caatttaaga acattttcat caccccaaaa    23700

agaaaccctg ttaccttcat tttccccagc cctaggcagt cagtacactt tctgtctcta    23760

tgaatttgtc tattttagat attatatata aacggaatta tacgatatgt ggtcttttgt    23820

gtctggcttc tttcacttag catgctattt tcaagattca tccatgctgt agaatgcacc    23880

agtactgcat tccttcttat tgctgaatat tctgttgttt ggttatatca cattttatcc    23940

attcatcagt tcatggacat ttaggttgtt tttatttttg ggctataatg aataatgttg    24000

ctatgaacat tcgtttgtgt tctttttgtt tttttggttt tttgggtttt ttttgttttg    24060

tttttgtttt tgagacagtc ttgctctgtc tcctaagctg gagtgcagtg gcatgatctt    24120

ggcttactgc aagctctgcc tcccgggttc acaccattct cctgcctcag cccgacaagt    24180

agctgggact acaggcgtgt gccaccatgc acggctaatt ttttgtattt ttagtagaga    24240

tggggtttca ccgtgttagc caggatggtc tcgatctcct gacctcgtga tctgcctgcc    24300

taggcctccc aaagtgctgg gattacaggc gtgagccact gcacctggcc ttaagtgttt    24360

ttaatacgtc attgccttaa gctaacaatt cttaaccttt gttctactga agccacgtgg    24420

ttgagatagg ctctgagtct agcttttaac ctctatcttt ttgtcttaga aatctaagca    24480

gaatgcaaat gactaagaat aatgttgttg aaataacata aaataggtta taactttgat    24540

actcattagt aacaaatctt tcaatacatc ttacggtctg ttaggtgtag attagtaatg    24600

aagtgggaag ccactgcaag ctagtataca tgtagggaaa gatagaaagc attgaagcca    24660

gaagagagac agaggacatt tgggctagat ctgacaagaa aaacaaatgt tttagtatta    24720

atttttgact ttaaattttt tttttattta gtgaatactg gtgtttaatg gtctcatttt    24780

aataagtatg acacaggtag tttaaggtca tatattttat ttgatgaaaa taaggtatag    24840

gccgggcacg gtggctcaca cctgtaatcc cagcactttg ggaggccgag gcaggcggat    24900

cacctgaggt cgggagttag agactagcct caacatggag aaaccccgtc tctactaaaa    24960

aaaatacaaa attaggcggg cgtggtggtg catgcctgta atcccagcta ctcaggaggc    25020

tgaggcagga gaattgcttg aacctgggag gtggaggttg cggtgagccg agatcacctc    25080

attgcactcc agcctgggca acaagagcaa aactccatct caaaaaaaaa aaaataaggt    25140

ataagcgggc tcaggaacat cattggacat actgaaagaa gaaaaatcag ctgggcgcag    25200

tggctcacgc cggtaatccc aacactttgg gaggccaagg caggcgaatc acctgaagtc    25260

gggagttcca gatcagcctg accaacatgg agaaaccctg tctctactaa aaatacaaaa    25320

ctagccgggc atggtggcgc atgcctgtaa tcccagctac ttgggaggct gaggcaggag    25380

aattgcttga accgagaagg cggaggttgc ggtgagccaa gattgcacca ttgcactcca    25440

gcctgggcaa caagagcgaa actccgtctc aaaaaaaaaa ggaagaaaaa tattttttta    25500

aattaattag tttatttatt ttttaagatg gagttttgcc ctgtcaccca ggctggggtg    25560

caatggtgca atctcggctc actgcaacct ccgcctcctg ggttcaagtg attctcctgc    25620

ctcagcttcc cgagtagctg tgattacagc catatgccac cacgcccagc cagttttgtg    25680

ttttgttttg ttttttgttt tttttttttg agagggtgtc ttgctctgtc ccccaagctg    25740

gagtgcagcg gcgcgatctt ggctcactgc aagctctgcc tcccaggttc acaccattct    25800

cttgcctcag cctcccgagt agctgggact acaggtgccc gccaccacac ccggctaatt    25860

tttttgtgtt tttagtagag atggggtttc actgtgttag ccaggatggt ctcgatctcc    25920

tgaccttttg atccacccgc ctcagcctcc ccaagtgctg ggattatagg cgtgagccac    25980

tgtgcccggc ctagtcttgt atttttagta gagtcgggat ttctccatgt tggtcaggct    26040

gttctccaaa tccgacctca ggtgatccgc ccgccttggc ctccaaaagt gcaaggcaag    26100

gcattacagg catgagccac tgtgaccggc aatgttttta aattttttac atttaaattt    26160

tattttttag agaccaggtc tcactctatt gctcaggctg gagtgcaagg gcacattcac    26220

agctcactgc agccttgacc tccagggctc aagcagtcct ctcacctcag tttcccgagt    26280

agctgggact acagtgataa tgccactgca cctggctaat ttttattttt atttatttat    26340

ttttttttga gacagagtct tgctctgtca cccaggctgg agtgcagtgg tgtaaatctc    26400

agctcactgc agcctccgcc tcctgggttc aagtgattct cctgcctcaa cctcccaagt    26460

agctgggatt agaggtcccc accaccatgc ctggctaatt ttttgtactt tcagtagaaa    26520

cggggttttg ccatgttggc caggctgttc tcgaactcct gagctcaggt gatccaactg    26580

tctcggcctc ccaaagtgct gggattacag gcgtgagcca ctgtgcctag cctgagccac    26640

cacgccggcc taatttttaa attttttgta gagacagggt ctcattatgt tgcccagggt    26700

ggtgtcaagc tccaggtctc aagtgatccc cctacctccg cctcccaaag ttgtgggatt    26760

gtaggcatga gccactgcaa gaaaacctta actgcagcct aataattgtt ttctttggga    26820

taacttttaa agtacattaa aagactatca acttaatttc tgatcatatt ttgttgaata    26880

aaataagtaa aatgtcttgt gaaacaaaat gctttttaac atccatataa agctatctat    26940

atatagctat ctatatctat atagctattt tttttaactt cctttatttt ccttacaggg    27000

ttttagacaa aatcaaaaag aaggaaggtg ctcacattcc ttaaattaag gagtaagtct    27060

gccagcatta tgaaagtgaa tcttactttt gtaaaacttt atggtttgtg gaaaacaaat    27120

gtttttgaac atttaaaaag ttcagatgtt agaaagttga aaggttaatg taaaacaatc    27180

aatattaaag aattttgatg ccaaaactat tagataaaag gttaatctac atccctacta    27240

gaattctcat acttaactgg ttggttgtgt ggaagaaaca tactttcaca ataaagagct    27300

ttaggatatg atgccatttt atatcactag taggcagacc agcagacttt tttttattgt    27360

gatatgggat aacctaggca tactgcactg tacactctga catatgaagt gctctagtca    27420

agtttaactg gtgtccacag aggacatggt ttaactggaa ttcgtcaagc ctctggttct    27480

aatttctcat ttgcaggaaa tgctggcata gagcagcact aaatgacacc actaaagaaa    27540

cgatcagaca gatctggaat gtgaagcgtt atagaagata actggcctca tttcttcaaa    27600

atatcaagtg ttgggaaaga aaaaaggaag tggaatgggt aactcttctt gattaaaagt    27660

tatgtaataa ccaaatgcaa tgtgaaatat tttactggac tctattttga aaaaccatct    27720

gtaaaagact gaggtggggg tgggaggcca gcacggtggt gaggcagttg agaaaatttg    27780

aatgtggatt agattttgaa tgatattgga taattattgg taattttatg agctgtgaga    27840

agggtgttgt agtttataaa agactgtctt aatttgcata cttaagcatt taggaatgaa    27900

gtgttagagt gtcttaaaat gtttcaaatg gtttaacaaa atgtatgtga ggcgtatgtg    27960

gcaaaatgtt acagaatcta actggtggac atggctgttc attgtactgt ttttttctat    28020

cttctatatg tttaaaagta tataataaaa atatttaatt tttttttaaa tta           28073


<210>  13
<211>  1634
<212>  DNA
<213>  Homo sapiens

<400>  13
ccacaaatgt gggagggcga taaccactcg tagaaagcgt gagaagttac tacaagcggt       60

cctcccggcc accgtactgt tccgctccca gaagccccgg gcggcggaag tcgtcactct      120

taagaaggga cggggcccca cgctgcgcac ccgcgggttt gctatggcga tgagcagcgg      180

cggcagtggt ggcggcgtcc cggagcagga ggattccgtg ctgttccggc gcggcacagg      240

ccagagcgat gattctgaca tttgggatga tacagcactg ataaaagcat atgataaagc      300

tgtggcttca tttaagcatg ctctaaagaa tggtgacatt tgtgaaactt cgggtaaacc      360

aaaaaccaca cctaaaagaa aacctgctaa gaagaataaa agccaaaaga agaatactgc      420

agcttcctta caacagtgga aagttgggga caaatgttct gccatttggt cagaagacgg      480

ttgcatttac ccagctacca ttgcttcaat tgattttaag agagaaacct gtgttgtggt      540

ttacactgga tatggaaata gagaggagca aaatctgtcc gatctacttt ccccaatctg      600

tgaagtagct aataatatag aacaaaatgc tcaagagaat gaaaatgaaa gccaagtttc      660

aacagatgaa agtgagaact ccaggtctcc tggaaataaa tcagataaca tcaagcccaa      720

atctgctcca tggaactctt ttctccctcc accacccccc atgccagggc caagactggg      780

accaggaaag ccaggtctaa aattcaatgg cccaccaccg ccaccgccac caccaccacc      840

ccacttacta tcatgctggc tgcctccatt tccttctgga ccaccaataa ttcccccacc      900

acctcccata tgtccagatt ctcttgatga tgctgatgct ttgggaagta tgttaatttc      960

atggtacatg agtggctatc atactggcta ttatatgggt tttagacaaa atcaaaaaga     1020

aggaaggtgc tcacattcct taaattaagg agaaatgctg gcatagagca gcactaaatg     1080

acaccactaa agaaacgatc agacagatct ggaatgtgaa gcgttataga agataactgg     1140

cctcatttct tcaaaatatc aagtgttggg aaagaaaaaa ggaagtggaa tgggtaactc     1200

ttcttgatta aaagttatgt aataaccaaa tgcaatgtga aatattttac tggactctat     1260

tttgaaaaac catctgtaaa agactgaggt gggggtggga ggccagcacg gtggtgaggc     1320

agttgagaaa atttgaatgt ggattagatt ttgaatgata ttggataatt attggtaatt     1380

ttatgagctg tgagaagggt gttgtagttt ataaaagact gtcttaattt gcatacttaa     1440

gcatttagga atgaagtgtt agagtgtctt aaaatgtttc aaatggttta acaaaatgta     1500

tgtgaggcgt atgtggcaaa atgttacaga atctaactgg tggacatggc tgttcattgt     1560

actgtttttt tctatcttct atatgtttaa aagtatataa taaaaatatt taattttttt     1620

ttaaattaaa aaaa                                                       1634


<210>  14
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Met Ser Ser Gly Gly Ser Gly Gly Gly Val Pro Glu Gln Glu 
1               5                   10                  15      


Asp Ser Val Leu Phe Arg Arg Gly Thr Gly Gln Ser Asp Asp Ser Asp 
            20                  25                  30          


Ile Trp Asp Asp Thr Ala Leu Ile Lys Ala Tyr Asp Lys Ala Val Ala 
        35                  40                  45              


Ser Phe Lys His Ala Leu Lys Asn Gly Asp Ile Cys Glu Thr Ser Gly 
    50                  55                  60                  


Lys Pro Lys Thr Thr Pro Lys Arg Lys Pro Ala Lys Lys Asn Lys Ser 
65                  70                  75                  80  


Gln Lys Lys Asn Thr Ala Ala Ser Leu Gln Gln Trp Lys Val Gly Asp 
                85                  90                  95      


Lys Cys Ser Ala Ile Trp Ser Glu Asp Gly Cys Ile Tyr Pro Ala Thr 
            100                 105                 110         


Ile Ala Ser Ile Asp Phe Lys Arg Glu Thr Cys Val Val Val Tyr Thr 
        115                 120                 125             


Gly Tyr Gly Asn Arg Glu Glu Gln Asn Leu Ser Asp Leu Leu Ser Pro 
    130                 135                 140                 


Ile Cys Glu Val Ala Asn Asn Ile Glu Gln Asn Ala Gln Glu Asn Glu 
145                 150                 155                 160 


Asn Glu Ser Gln Val Ser Thr Asp Glu Ser Glu Asn Ser Arg Ser Pro 
                165                 170                 175     


Gly Asn Lys Ser Asp Asn Ile Lys Pro Lys Ser Ala Pro Trp Asn Ser 
            180                 185                 190         


Phe Leu Pro Pro Pro Pro Pro Met Pro Gly Pro Arg Leu Gly Pro Gly 
        195                 200                 205             


Lys Pro Gly Leu Lys Phe Asn Gly Pro Pro Pro Pro Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro His Leu Leu Ser Cys Trp Leu Pro Pro Phe Pro Ser Gly Pro 
225                 230                 235                 240 


Pro Ile Ile Pro Pro Pro Pro Pro Ile Cys Pro Asp Ser Leu Asp Asp 
                245                 250                 255     


Ala Asp Ala Leu Gly Ser Met Leu Ile Ser Trp Tyr Met Ser Gly Tyr 
            260                 265                 270         


His Thr Gly Tyr Tyr Met Gly Phe Arg Gln Asn Gln Lys Glu Gly Arg 
        275                 280                 285             


Cys Ser His Ser Leu Asn 
    290                 


<210>  15
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
ccagcauuau gaaag                                                        15


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modified by a 2'-MOE modification and a phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by a 5-methyl cytosine and 2'-MOE modification and a 
       phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by a 5-methyl cytosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by a 5-methyl cytosine

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by a 5-methyl cytosine

<400>  16
tcactttcat aatgctgg                                                     18


<210>  17
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
cuauauauag auaguuauuc aacaaa                                            26


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
aaggugucga ugcacuaca                                                    19


<210>  19
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
gcauuguaac gccuaucg                                                     18


<210>  20
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
gcagaugaac ucgggaug                                                     18


<210>  21
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
cgucuacuug agccacuac                                                    19


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
ccgcacucgu ucucgaucut t                                                 21


<210>  23
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
agggcgugag caagagcuag a                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
gcuagaugga agaacacuat                                                   20


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
ctcgaucuac cuucuuguga u                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
ggacugccuc caaguggaat t                                                 21


<210>  27
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
gaccugacgg agguucaccu u                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
ccucgaaaug auagacgaat t                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
ttggagcuuu acuaucugcu u                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
gcauaggguu gacugauaat t                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
ctcguauccc aacugacuau u                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
cgacgucccu uugauccaat t                                                 21


<210>  33
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
gggcugcagg gaaacuaggu u                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
ggauaccucu aguaaagaat t                                                 21


<210>  35
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
agccuaugga gaucauuucu u                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
ggauuauuua auaacauuat t                                                 21


<210>  37
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
aaccuaauaa auuauuguaa u                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
cgucagcgug uaucaggaat t                                                 21


<210>  39
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
gcagucgcac auaguccuu                                                    19


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
ggccguggua guuacucaat t                                                 21


<210>  41
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
gaccggcacc aucaaugagu u                                                 21


<210>  42
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
cagagtggtt gtctctg                                                      17


<210>  43
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
ctccacgaca ccagtgcc                                                     18


<210>  44
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
ggacgccgga gccgcag                                                      17


<210>  45
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
gagatcgaga acgagtgc                                                     18


<210>  46
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
atgcatcgtg attcctg                                                      17


<210>  47
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
ctgcgacgag gtggagg                                                      17


<210>  48
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
gttacggttc tggacgc                                                      17


<210>  49
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
gctccgggag cgggag                                                       16


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
gatccaaggg atgcagatg                                                    19


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
ctatcatttc gaggtctgcg                                                   20


<210>  52
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
gtggatacag cagtcgg                                                      17


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  53
ctggatctgc ttccagag                                                     18


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
ggtctagatc acattctcg                                                    19


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  55
ccagacctag atcttctg                                                     18


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
caggagcgag aacccgag                                                     18


<210>  57
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  57
cttctgcata tggtacgac                                                    19


<210>  58

<400>  58
000

<210>  59

<400>  59
000

<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
gttacccagc acgtgtacc                                                    19


<210>  61
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
ggcctgaagg tcatctcc                                                     18


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
gagtacattg aagagaacaa g                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
cactgtgtca tcgaagtgtt c                                                 21


<210>  64
<211>  28073
<212>  RNA
<213>  Homo sapiens

<400>  64
ccacaaaugu gggagggcga uaaccacucg uagaaagcgu gagaaguuac uacaagcggu       60

ccucccggcc accguacugu uccgcuccca gaagccccgg gcggcggaag ucgucacucu      120

uaagaaggga cggggcccca cgcugcgcac ccgcggguuu gcuauggcga ugagcagcgg      180

cggcaguggu ggcggcgucc cggagcagga ggauuccgug cuguuccggc gcggcacagg      240

ccaggugagg ucgcagccag ugcagucucc cuauuagcgc ucucagcacc cuucuuccgg      300

cccaacucuc cuuccgcagc cucgggacag caucaagucg auccgcucac uggaguugug      360

guccgcguuu uucuacgucu uuucccacuc cguucccugc gaaccacauc cgcaagcucc      420

uuccucgagc aguuugggcu ccuugauagc guugagugga ggcccugccg cgacuuggca      480

guagcuuauu uuguucacuc cucucuggcu gguguggggg aggugggggc auuaggccag      540

ggugaagcag gggaaccacu uaggagucug uuaagaugau cugaacuuca gaacaagaug      600

uuauuaacag agugaaagua uuuggauucu ggguauauuu ugaaaucgga ggcaacaggu      660

uuuucagaua gauucgauaa cggagguuau ccugaauagu ugaaaagaua aaguugccuu      720

uugcugaggu gggaaagaga agauugccag uagagcaggu uucucaggag uucagucuug      780

ggcauagcau gguaggggug aauuuggcug gagugaguug gagaguagga gaagagaaau      840

ccaaggcaac auuugaccag ccugggcaac auagugugac uccgagucug caaaaauuag      900

acggguguug uggugcgcgu cuguggucuc agcuaccugg aagguucagg ccuuggaagg      960

cucagggagg uggaggcugc agugaucugu gauugcgccu cugcacucca gccugggcga     1020

cagagccaga cccugucuua aaacaaaaua aacggccggg cgcgguggcu caagccugua     1080

aucccagcac uuugggaggc cgaggcggcc ggaucacaag gucaggagau cgagaccauc     1140

cuggcuaaca cggugaaacc ccgucucuac uacaaauaca aaaaauuagc cgggcguggu     1200

gacgggcgcc uguaguccca gcuacucggg aggcugaggc aggagaaugu caugaagccg     1260

ggaggcggag cuugcaguga gccgagaucg cgccacugca cuccagccug ggcgauagag     1320

caagacuccg ucucaaauaa auaaauaaau aaauaaauaa auaauaaaaa caucgguagg     1380

cauauuucaa ggaauucuau uuaaaaaaaa uuuuuuuaga gacaaguucg cucucugugg     1440

cccaggcugg aguacagugg caugauccua gcccauggca gcguugaucu cuuggccuca     1500

agcgacccuc cuuuggaguc gcugggccua aaggagugag ccaccacgaa auuuuauuau     1560

aaauggaggg uagagaaauu gggcaauaaa uggaggggga agugaguuaa gaggaauuuu     1620

aauuaugugu gugugguuuu aaaagagggg ggucuugcuc uguugcccag gcugcugggg     1680

ugccaguggc gcaaucauga aucacuacag ccuuggacuc cuggccucaa gcuauccucc     1740

caccucugcc ucccaaagua cugggauuac uagugugagc cacugcacua agauaggagc     1800

aacauguuuc agcauguuug uggguugaua ggaaagauga gaaugggaaa guugaugucg     1860

gaaagaagac aauggcuaga gcaauguccu agaguaggua agaagggaug gauuuggccu     1920

uuguuggaaa cauuagcggu ucuuuuggug acagcuauau aguuaacaca ucuaugauac     1980

gugaaugggc agauaggaug gcaggagauu uugaaaguuc ucuugauucu uacuguucuc     2040

uuagugaaag aagcaagguu aucagcuaga agcugggaug ggagaggaaa gagaagaugg     2100

gaaguagaua guucuuuaga agagugggca aggguuggac uagggaaguu uaguggaaau     2160

auugcuaggc aacauaaaga gccuacuuga gauucguggu caugaguuga aggagaccag     2220

acagcaagau uguguaugag ggcacccaca gaguaaaugg agaguugaaa uuaaugcagu     2280

ugugauuuua ccacguggau augaagaagu gagggggaga aguacaaagg aguucucuua     2340

augauugacc auggaauuua agcuggcuaa gaaaggaagu gagaggccgg gcgcgguggc     2400

ucacgccugu aaucccagca cuuugggaga cugagguggg uggauuaccu gaggucagga     2460

guuugagacc aaccuggccg auauggcgaa accccaucuc uaauaaaaau acagaaaaau     2520

uagccgggaa ugguggcagg ugccuguaau cccagcuacu caagaggcug uggcaggagu     2580

aucccuugga cccaggaggu ggagguugca gugagccgag aucacgccac uguacuccag     2640

ccuggacgau auagugagac uucaccucaa aaaaaaaaaa aaagaaagga agugaggauu     2700

uuaagacccu gagagacagu uuaaaaagug ggaggaucgg ccgggcgcug uggcugacac     2760

cuguaauccc agcacuuugg gaggccgagu ugggcagauc acaaggucag gaguucgaga     2820

ccagccuggc caauauggug aaaccuuguc ucuacuaaaa auacaaaaau uagccgggca     2880

uggugucacg ugucuauaau cccagcuacu cgggaggcug aggcagaaaa auugcuugaa     2940

ccugggaggc agagguugca gacagcugag aucacuccau ugcacuccag ccugggcaac     3000

aagagcaaaa cuuugucuuu aaaaaaaaaa aaaaaaaaag aauacaaaaa uuagccgggc     3060

gugguggcgc gugccuauaa ucccagcuac uugggaggcu gaggcaggag aaucaguuga     3120

acacgggagg cgagguuugc agugagccga gauugcgcca cugcacucca gccugggcga     3180

cagagcagga cuccucuugg aaaaaaaaaa uuagcugggc augguggcag gugccuguag     3240

ucucagcuac uagggaggcu gaggcaggaa aaucacuuga acccgggaug uggaguuugc     3300

agugacccga gaucgugcca cuguacucca uccugggcga caaaaugaga cucugccuca     3360

aaaaaaaaaa aaaaaaaaag ugggaggauc aauguacugc caguccuaau gaaguggaau     3420

gauugucccc aucaaaucac uaguaggagu aaguugcaga gccuagaagg ugaugguuaa     3480

gagaguggga uucuugaaac ugcauuuaug gagagguugu gguuauuggu uauaauaaau     3540

aaauacaguu gaagugagug aguagcugag auuuggggau guaucaguuc auucuuacac     3600

ugcuacaaag acauaccuga gaccagguau uuauaaagau aagagguuua aucagcucac     3660

aguucugcug ccuguacagg cuucucuugu ggaggccuaa ggaaacuuac agucauggug     3720

gaaggugaag gggaaacaag cacagucuuc acauggccag caggagagag agagaagggg     3780

gaagugcuac auacuuuaaa acaaccagau cuugugagaa cgcuuaucag gaaacagcac     3840

uuggggaugg ugcuaaauca uuagaaauca cccccaugau ccagucgccu ccuaccaugc     3900

ccaccuccaa cacuggggau cacaauucag caugagauuu ggguaggaac acagagcugc     3960

accacaucag aggauguaca agauuguggu ggagaggagu uuagagaccu gcaaauauag     4020

gguaauugaa gggaucaucu acauggauau uuaaaucacc aaaaauuaug acaggaguag     4080

uguuggagag agaacugcga uguaaacauu aaggaaugag gaagagugac ucgguaggcu     4140

guaggugacu gcaauaggaa acgauaauag acugugaguc uggugacaag auuuuccuuc     4200

uuucuuuuuu uccccccccc cgagacaggg ccucuuuuug uugcccaggu gggagugcag     4260

uggcgcgauc acggcucacu acaaccuccu cccaagcuca agggauucuc ccacuucagc     4320

cucucaagua gcuggaacua caggugcuga ccaccaugcc uggcuacuuu uugucaggau     4380

uuucaaggcu gggaauuuug agaggggaau ggaggagaau aaucugaaag ugcaaguaag     4440

gagcagggaa gauuucuuuu uucuuuuuuu uuuuuuuuuu ugagucggag ucuggcucag     4500

ucgcccaggc uggagugcag uggcgagauc uccgcucacu gcaagcuccg ccucccgugu     4560

ucacgccauu cuccuccuuc agccucccga guagcuggga cuacaggcgc ccgccaccac     4620

gcccagcuaa uuguuuuuuu guauuuuuag uagagacggg guuucaccgu guuagccagg     4680

auggucucaa ucuccugacu uugugauccg cccaccccgg ccucccaaag cgcuugggau     4740

uacaggcgug agccaccgcg ccagccagag cagggaagau uucuucccca caucuccagu     4800

agguacagug auaugaagug uguggaggag aaaagaggaa acaucuauca uuugagaugg     4860

cugcgaaagg aaaaggcauc cucagggagc uagauuuuac uuagagcaag aaaugaaggg     4920

augauucaga gguuaaaaga guggauuuua ugaauuacuc aagggagcac aguggaaguu     4980

ucaggaagug guaggagaag guagaagaug gcaggguguu gggaauaauu ugagaaaucu     5040

gagcuacugg aaaugacuga gaaucagaua uaaaggcagu ccuggugguc cguucuggcu     5100

gccguugcug uguaacgaau cugccaaaac uuaguggcuu gaaacaacaa agaacauuuu     5160

auuaucucuc auuguuucug uggguuagga auuugugaga gccgugcugg gcaguuuucg     5220

ugcggcuguc ucgugguugc accuacauag uugcuagagc uacaguagcu ggggacugag     5280

cagcuaggga uuggcaggcu aucucuuuuu uucauguagu cucaugaaga uuucuuuaug     5340

ugguuucaau gugugggcug guuuggauuu ccuuauagca ugguggccuc aguuggauug     5400

cuguuuugug auccuuuuca ucccuccuug uccugucccc agacaaccac ugaucuacuu     5460

ucugucacca uagauuagcc ugcauuuuua agaauuuuua uaaacgugga augauagagu     5520

accuuuuuug ucacguuucu uuuauuuauc auagcuauuu ugauuuucau ccauuuuauu     5580

gcugaguagu aucccauugc auguauauac uauacuguau ucauucgcuu gcuugugaac     5640

auuugggcuu uuuccaguuu gggacuguua acaaguagag ccacuaugaa uauuagugua     5700

uaagacuuca uauagccaag gcuggcagau cgcuugagcc caggaguuug agaccagccu     5760

gggaaacaug gugaaaccuc uauuuuuauu uuaaaaucaa aaauuaaaaa uuuucuauaa     5820

aaaauuuuaa agaagacuuu guauagacau acgcuuucau uuuucuugag ugaauacuua     5880

ggucucaggg uagauguauu uuaagucuuu aaggagcugu caaacucuuc cucaaagugg     5940

ugguuguacc auguuacuuu uuaauauaac agagauuaau ugagcaaaga aaaauucaaa     6000

aguuggacag cccccacaac uaaauagguu cagaacagcu cccccauuuu gcauuuugac     6060

cagcaaugua ugaaaguucc auuugcucag ugucccugca aacaccuggu auggucaguc     6120

uuuuuaauuu uaggcauuau aauagauaua guggcuucuu gugauuuuaa uuagcauuuc     6180

cuaaugacca gugcugcugu ugaucauuuc augaguguau uugccauccg uauaucuuuu     6240

uuggugaagu gucuauucaa aucauuuggg uuuuuuuuuu uuuuguuuuu uuuuuuugga     6300

gacagugucu cacucuguca cccaggcugu ugugcagugg ugcaaucaca cagccuacug     6360

cagccuccac cuccugcgcu cagucuucuu gucucagccu ucugaguagc ugaaauuacg     6420

agcacacgcc acaaugccug gcuaauuuuu uaaaauuuug uagaaacaag gucucauuau     6480

guugccuggg cuugucguga acuccugggc ucaagcaauc uuccugccuc agccucccaa     6540

agauugggau ugcaaguaug agccacugca cccggccaac uuacccaucu uuuaauugaa     6600

uuuuuuuguu guugagguuu gagaguucuu cauguuugcu ggguacaaua ucuuuaucag     6660

auagguaacu ugcauguauu uucucccggu uuacacuuug guuuuucauu uuguuaacaa     6720

cgucuuuuua agaacagaaa aucuuaauuu ugcugaaauc uaauuuuuca guuuuuucuu     6780

ugaugguuuu gagagaggag guaaaaaaag acuagguaag ccgauaguua gacagagucc     6840

ucgguagaac uucccuucua acaaaaagca gcccaagaaa ucacuucucu ucuaacaagg     6900

agcagccugg aagaucgggc uguaaacaug uauaaggaag cagcucuggc acagaggggg     6960

agcuuccugg guaaucagca agcuucacau acguaaggug gguaugugaa guaaacacag     7020

uaugugaagu aaacacagug gaccuuagua cauacucaga uaaggaagcu ggaagcuugc     7080

auguugugag uuguuggggu ugccugcagc ugcacggaga gaaaggggua ccuggggcca     7140

ggcaugucca ccaugguggc uccaccuccc cuuauuuagc acaugcacaa uaggaaagag     7200

auaagcaaug uggaguagcu caggccaagg accugccugc auaauaaaag guuggggugg     7260

gggaugccag agauucacgc ucugugcaga uggcaacacc ugguccuaac ugguuuuuug     7320

cucccuaugu guagauaagc uacccccuuc ccauuagcuc auuuauaaaa augcuugcau     7380

uucacugugg aaugggaacu cuuuucagga ccucucucug caggagagag cuagucucuu     7440

ucuuuugccu auuaaacuuc ugcucuagcc ucacacccuu ggugugucag cguccuugau     7500

uuccucagcg ugagaccaag aaccucgggu gccaccccag gcaacaaggc cauuucaguu     7560

uguucuuuug uuauaggcaa uccaugauca cagauuuuuc ucucuuuuuu uuuuuuacac     7620

aguuuagagu uuuaguuuua cacuuagguc uguaauccau uuuguauuaa uucuuauaug     7680

uggcucagug uagguggaaa uuugguuugu uuuugcauaa ggauuuccaa uaguuuuacc     7740

accauuucuu gaaacuacua ugcuuucucu auuaaaccac auuuguaacu uuaguuaaaa     7800

ucagucacau auaucacagg gcuauuucug acucucaauu cuguuacauu gucuauuagu     7860

guauauugau gucaguacua cacuuuuaau uacuauugcu ucaggguaug ucuuguaaac     7920

caaaaauaaa auuauaggcc ccccccgccc cugcacaacc aacugaaugg acccauccuc     7980

ucagccaagg gcauuccaaa auuaaccuga aaaacuaguu caagccauga ugggaagggg     8040

gaguuggaca ugucucauca cacccuacua ccuuuuggaa uuacugauag aacagacucu     8100

uaaagucuga aaagaaacau uuacaaccua cccucucuga agccugcuac cugggagcuu     8160

caucugcaug auaaaaccuu ggucuccaca accccuuaug guaacccaaa cauuccuuuc     8220

uguugauaau aacucuuuca acuaguugcc aauuagaaaa ucuuuaaauc uuccuaugac     8280

cuagaaaccu cccuaccccc acuuugaguu guccugccuu uccugacaga acucauguac     8340

aucuuacaua uauugauuga ugccucaugu cucccuaaaa uguauaaaac aaagcuguac     8400

cccaccaccu uggggacaug ucaucaggac cuccuguggc ugugucauag gagcgucuuu     8460

aacuuuggca aaauaaacuu ucuaaauuga uugaaaccug ucuuagcuac uucugguuua     8520

cagucuuaaa guuagauaau guaaauuguc cagcuuuggu uuauuuuugu ccuuaguagu     8580

uccauauaaa uuuuagaauc agcuuuucaa uuuaauacac uacuuuccuc uuagauccac     8640

aauuaaauau auuugaugcu aacaauucug uuuuauguuu uucguuuuuu uuuuuugaga     8700

caagaguuuc gcucuuguug cccaggcugg agugcagugg cgcgaucuug gcucaccaca     8760

accuccaccu cccagguuca agcaauucuu cugccucagc cucccgagua gcugggauua     8820

caggcaugcg ccaccacgcc cggcuaauuu uguauuuuua guagagacgg gguuucacca     8880

uguugaucag gcuggucuug aacuccugac cucaggugau ccacccaccu cggccuccca     8940

aaguguuggg auuacaggcg ugaaccacca ugccuggcca guucuguuau uuuuaaaacc     9000

caaguuuccc uggucauauc uugguuggau gaagcguauu uucaauagau uacccuggaa     9060

aggcuaguga guacgguauu cuucuacauu uuagacuuuu cuuagucuug cuacuucaag     9120

gacagcuagg cugcauauaa aauucuuggc ucauacuuuu uccccauaaa uuucuaugag     9180

aaagucuaau gauaacugau uuucuuuauu uuguaacuua gucuuuuugc uuagaggcuc     9240

ucugaggaug ggaggggguu cuuccuccca ucccuaggaa uuuuucuuuu uuuuaaauuc     9300

cuaaucacua gaccaccagg aagauuguuu guuuuguuuu guuuuuauuc uucagggacc     9360

ccauuuauac auacguuaaa uaaauacugu uugccaaugu aucaaccauu uugcuucuua     9420

uuuauuuuug uuccuuuggu ucuuuuucau ggcuuugcuu uggugcuccu uagauuuuca     9480

gucagaugua uuuguccuug gguaccuugu aaucaguauu accuuuucuu cugucgcuuu     9540

guuuucuguu cguuuugaaa uuacuuguuu ccuggucugg caauaacagu ugagauauga     9600

ggaguuugag cugccaucug ucuauguauc uugcuuuaag acugcacucu ucuauugaua     9660

ucacuggccu ugauuuugug auuucuuuau uucuucagga ccacccuuca uuuucuacug     9720

uuugcuuccu uuuuuuuuga gauggagucu cacucuguca cucaggcugg agugcaguga     9780

ucuuggcuca uugcaaccuc ugccucccgg guuccagcaa uucuccugcc ucagccuccc     9840

aaguaucugg gacuacaggu gugcaccacc augcccggcu aaguuuugua uuuuuaauag     9900

agacgggguu uugccacauu ggcaggcugg ucucaaacuc cugaugucaa gugauccacc     9960

caccccaccc accucugcau cccaaagugc ugggauuaca ggaaugagcu gccgugccca    10020

gccucccccc uaccccccuu uuuuucuuuc gagacagaga uuauaggugu gagccacugg    10080

acccagccug uuuuuauucc uuuuaccaaa ucuccaagga auaucuuccc uuccaagugc    10140

gaauguaacc uuaagucagu uaaccucuuu gugauuacuu uucuuaucug caaagugacu    10200

uaaugaucuu aaguacuuuu uuuuuuugag acagggucuc acugucaccc uggcuggagu    10260

gcaguggcac gaucucugau cuccacucac ugcaaucucc ucuucccugg uucaagcggc    10320

ccucccaccu uagccuucug gguagcuggg acuacagaug ugaaccacca cgcccagcua    10380

auuuuuguac uuuuuguaga gaugggguuu ugccauguug cccaggcugg gauuauuaag    10440

uacuuuuuau cauacagcaa gauugacauu uuauauugga auacauuugu cucuauauaa    10500

cggagauuaa caggaaaaug acaagccugg gugcgguggc ucaugccugu aaucccagca    10560

cuuugggagg cugagguggg aggaucacuu gaggucagga guucgagacc aguuuugcca    10620

agaugaugaa agcccauguc uacuaaaaau acaaaaauua gcccagcuug auggugggcg    10680

ccuauaaucc cagcuauuug agagacugag gcaggagaau cacuugaacc ugggcagcag    10740

agguugcagu gagccgagau caugccacug cacuccagcc uggguggcau agcgagacuc    10800

uugucucaag agaaaacaaa acaaaacaaa aaaaaaacag gaaaaugaca aaaaguaaua    10860

uuacaacuca gugaauuuua uaacaaacuu uuuuggaauu cauugacuaa uacuauacca    10920

aauccaaaau acucucuagu auaccaaauc caacucuacc cuauaguaua aauuggauuc    10980

uauuuggacu ugucucacua aucccucaua caguguguuu uauuuuuuau ugaaguaaaa    11040

aaauuuguca uuuuaaccau uuuuaaguau auaguucagu aauauuaagu auguucaugu    11100

uguugcgcaa uagaucuucg gaaguuuuuc gucuugcaac cugaaacucu acccauuagc    11160

aaauucccau uucuccuuac acuuagcccu ugguaaucau cauucuuuuu uuuuuuuuuu    11220

ugagauggag uuuuacucuu guugcccagg cuggagugca auggugcaau cucgacucac    11280

cacaaccucc gccucccagg uucaagcaau ucuaccucag ccucccgagu agcugggauu    11340

acagucaugc accaccacgc ccggcuaauu uuguauuuuu aguagagaag ggguuucucc    11400

auguugaggc uggucucgaa cuccugaccu caggugaucu gcccaccucg gccucccaaa    11460

gugcugggau uacaggcgug agccacugcg ccuggcccau ucuuucuaau ucuauaaauu    11520

ugacuacuua guuaccuuac auaaauaaau ucuuauaguu aguguuauuu uugcuuccau    11580

gccuuuuuug uuguuguuca ugcucuuacu uggaaugcgu ucuauuuugu cuaccuaugc    11640

acauccuguu ggguuuuuuu uuuuuuuggg gguuuuuuuu guuuuuuuuu guuuuuuuuu    11700

cccagacaag gucucaauuu guuacccagg cuggagugca gcggcgccau cuccacucac    11760

ugcauccuca acuuccuggg cccaggugau ccucucgccu cagccccugc agguagcugg    11820

gacuauaggc augugccacc augcccagcu aaauuugguu uuuuuguuug uuuguuuuug    11880

agacagaguc ucacucuguc acccaggcug gagugcagug gcacaaucuc agcucacugc    11940

aaucucugcc gcccggguuc aagugauucu ccugccucag ccucccaagc agcugggauu    12000

acaggugacu gccaccacgc cagcuaaguu uuguaguuuu aguagagaug ggguuucacc    12060

uuguuggcca ugcuggucuc gaacuccuga ccucgugauc ugccugcuuc ugccucccaa    12120

agugcuggaa uuacaggcau gagccaccac gcccggccag aauuuuugua uuuuuaguag    12180

acacaagguu cuuacccugu ugccuaggcu ggucuggaag uccuggacuc aagcaauuca    12240

ccugccuugg ccucccaaaa ugcugggauu acaagccacc augcccggcc uaaauccugu    12300

uguuuuguuu uguuuuauuu uguuuuguuu uguuuuguuu guuuuuugag acagagucuc    12360

gcuaugucuc ucaggcugua gugcaguggc gcgaucuugg cucacugcca ccucugccuc    12420

ccagguucaa gugauucucc ugccucagcc ucccaaguag cugggauuac aggcaugugc    12480

uacuaugucc ggcuaauuuu uguauuuuua guagagacag gguuucacca uguuggccag    12540

gcuggucucg aacuccugac cucgugaucc acccaccucg gccacccaaa gugcugggau    12600

uacaggcgug agugguuuuu auuucuuagg ccgguuuccu ccauaugauc uugcaguaga    12660

cauuaauuuc uuuccuuuuu aauuaaaaua cuguuuguau uucacauuuu gauguuuguu    12720

aagauuuguu uuauauuguu uuuuguuuug ucuuguguga uagucuuaaa ucccuaguua    12780

gauaauaacu ggagaguacc auguuucuau auaucucuca gugacuugca cagugcuagc    12840

agauagugcu aaaaaauuau uuauuauuau uauuauuuug uuauuguugu uguuguuguu    12900

agacaggguc uuccucuguc acccaggcua gagggcaaug ggaugaucau agcuuacugc    12960

agccuccaac aacugggcuc auguaauucu ccugccucag cuucccaagu agcugggauu    13020

acaggcauga gccaccaugu cuggacaaaa auauuuccag gugcaguggc ucaugccugu    13080

aauucccaca cuugggaggc cgagcgaggc uggaggauca cuugagccua ggaguucaag    13140

accagcuugg cuaagauggc gagaccccgu cccuacaaaa aauuuuaaaa acuagccagg    13200

caugguggca ugcaccuaua uucccaacua cucagugggc ugagguggga gggucauuug    13260

aacacaggaa uuugagggga gaaaaaaaga agagagaaag agaagugaag gaaggaagaa    13320

aggaaggagg gagggagaga agaaagaaac gaaagaaagg aaaagaaaag gaaggaaaga    13380

aaauugguac caggaaagca ggaaagggaa auggaaguaa aaaaauaaua auaauaauaa    13440

aaugaaaauu gguuagucac uauuaacaau uuguauccuu auaaucugga aacauuauaa    13500

uuucaaaaga aaaaauauuc uuuggaucau agguucugag gucagaacag cauucccgua    13560

gucuagauga agucaaguuu uaucugaucu uaauugaaau aaauauagcu ggccuugaac    13620

aaaucuacuc augguaugug gauaggaauu aaauuguagg ggcauucacu ugauggcauu    13680

cauucuuaga acauuuaccu augucuagcu uuuggaguaa agucacauaa ccucuaacca    13740

gguaaguuuc cuguggcuuu auuuaggauu uuaaauacuc auuuucagug uaauuuuguu    13800

auguguggau uaagaugacu cuugguacua acauacauuu ucugauuaaa ccuaucugaa    13860

caugaguugu uuuuauuucu uacccuuucc agagcgauga uucugacauu ugggaugaua    13920

cagcacugau aaaagcauau gauaaagcug uggcuucauu uaagguauga aaugcuugcu    13980

uagucguuuu cuuauuuucu cguuauucau uuggaaagga auugauaaca uacgauaaag    14040

uguuaaagua cauguuauuc aguuuucauu uugaagauua gaugguagua ugaguuaguu    14100

aaaucaggug auauccuccu uuagaaguug auagccuaua uaugucaucc uuuguggagg    14160

caauuuaaau aaaauuuaaa acauuuauuc cuggcugggu augguggcuc acuccuguaa    14220

ucccagcacu uugagaggcu gaggcgggug gaucaccuga ggucaggagu uugagaccag    14280

ccuggccaac auggugaaac cccgucuuua cuaaaaauac aaaaauuagc caagcauggu    14340

ggcacgugcc uguaauccca gcugcuuggg acacugaggc aggagaauug cuugaaccug    14400

gggggcagag guugcaauga uugcaccacu gcacuccagc cugggcgaua gagugagacu    14460

ccaucucaga aaacgaacaa acaauguauu ccuuuuagua uuuuuacauu guaucaaacu    14520

auggaagucc ucuaauugag auuaauaaga aaaagacaau cugaauuaua auuuuaaaca    14580

uuuaacaagc auguaguaaa auaaugauga agauaaauag cauuaguaca gcaauuaaua    14640

uuuguagcau gcugacagug cucugugugc guuucauaua uuaaauuacu cuaaucaucc    14700

caaauccugu aaguugggua ucaauucaag uguuccuauu ggguaggaau auacaguucu    14760

uuuaggaaau guaguauggu ucugugucuc aaacaggaca cuuacacagu uggccaacau    14820

caucaccuuc uccauucucu gagauguuua gucuuacuga gcacuaaaua ugggucauca    14880

auaguccaga cuaccuugag caaacaauag uccagacuac cuugagcaaa cagagcauau    14940

acucauacag uguauaaaga gcaccaagca uacagauuuc augucuuucu cauaguuacu    15000

cuuguaacau gagcuaaaga ucagaccucu augucaccuu uguaacugau uucuagauuu    15060

uuuuuuuuuu uugagauggg gucuugcccu gucacccagg cuggagugua guggcgugau    15120

caugccucau uggagccuuc aacucaugag cucaaacaau ccuccuaccu cagcuuccug    15180

aguaguuggg accacaggug ugugccacca cacccagcuc auuuuuguau ucuuuguaga    15240

gaugcagucu cacccuguug cccacgcugg ccuggaacuc cugagcucaa aagaucccuc    15300

cgccuugacc uuccaaagug cugggauuac aagcaugaac cacugcaccc ggccuagauu    15360

uuuaaaugug cuuuccagua uacacugaaa cuagaagucg acuaaagaau uaccaagaga    15420

auucuauaaa auagagauug aaauggggcu cgauguggga uggguuggug auauugcagg    15480

gagaaguaau cugaguaaag gaggaaaaga acugauuugg gaaaacgaua guuuuaguag    15540

ugaguuugag uaugaauuaa guugagauug aauuugaauu aaguugaggu ugaauaugaa    15600

uuaaguugag guugaguuug agguaugaau uaagauguga aauugaucau uggaaauguu    15660

agauugagaa aagucacagc uggauuaaua gcuucagaag uguguuugca gacaguugca    15720

acuaaaguaa uaagaauaga uggccuuggc cgggcgcggu ggcucacgcc uguaauccca    15780

guacuuuggg aggcugaggc gagcaaauca cgaggucagg aguucaagac cagccuggcc    15840

cacaugguga aaccccgucu uuauuaaaaa uacaaaaauu agcugugcac aguggugcac    15900

gccuguaauc ccagcuacuc gggaggcuga gacaggagaa ucgcuugaac cugggaggug    15960

gagguugcag ugagcugaga ucagugugac ugcacuccag cccggugaca gagugagacu    16020

cuguguaaaa aaauaaaaua aauaaaauaa uggccguaag caaguaaaga aggauggcca    16080

gcucuuauug ggaaugccua aaucuaaggc uugaucagaa guaaugaaac cguuggggcc    16140

cuacauugcu augacaucca aagggccaug aauaucagga agaaagauaa uuaacagggu    16200

cuaauguuac agagagguug agagcaagga gauuugauua aaagggucuu uagagcugau    16260

gucaggugua ugaugccuuu aagagcaguu uuuauagugc aggggguggu caaaagagaa    16320

aauaggugcu uucugaggug acggagccuu gagacuagcu uauaguagua acuggguuau    16380

gucgugacuu uuauucugug caccacccug uaacauguac auuuuuauuc cuauuuucgu    16440

agcaugcucu aaagaauggu gacauuugug aaacuucggg uaaaccaaaa accacaccua    16500

aaagaaaacc ugcuaagaag aauaaaagcc aaaagaagaa uacugcagcu uccuuacaac    16560

agguuauuuu aaaauguuga gauuuaacuu caaaggaugu cucauuaguc cuuauuuaau    16620

aguguaaaau gucuuuaacu uaagugauua guacaguguu ucuauugaca uauacuuaua    16680

caacuucaaa aacaacuauu aaauuuucug uuauuuagga acaugcauau uagucaugaa    16740

aguauaaaga auuagauggg aaugauaaau gcuaaaauca ggacaugugu uccauuugug    16800

aauggaaggc agggagaagg ugccguuugg aaggaguacc caagagccgu aagcugaauu    16860

ggcaguguuu uacaucuuaa gcugagagau agauuuuuuu uuccccuuuu ucuuuaaaaa    16920

cucuaaaacu guuaauucca aggaacccag aagucuaggu agauuauuuc ugcuaguuaa    16980

aagcaguagu ccugaaagcu gaauauuuug gugucuuuug agccaacuuu aguuucauca    17040

uuaccaaggg ggaagagagc uaacaguuga ugagcacuug cucuaggcca guccagagug    17100

cugggcacca uacgcauuuu aucucccucc cgcuauucac aacaaauaug ggagguaguu    17160

uauauuauag ccaucuaaua agauggggaa acuaagacuc aaagagauuc agaaacuugu    17220

ccaugauuau aaauguaaga gaguuggaau ucagauuuau guauuuagac cccaagccuu    17280

ucucauuaca ucauuuugcc uuccaaaucu cuacccucua uccuucaccu ccccacugau    17340

caaaacgaga ugauaguuug cccucuucaa aagaaaugug ugcauguaua uaucuuugau    17400

uucuuuugua guggaaaguu ggggacaaau guucugccau uuggucagaa gacgguugca    17460

uuuacccagc uaccauugcu ucaauugauu uuaagagaga aaccuguguu gugguuuaca    17520

cuggauaugg aaauagagag gagcaaaauc uguccgaucu acuuucccca aucugugaag    17580

uagcuaauaa uauagaacaa aaugcucaag agguaaggau acaaaaaaaa aaaaauucaa    17640

uuucuggaag cagagacuag augagaaacu guuaaacagu auacacaguu gucaguuuga    17700

uccaccgagg cauuaauuuu uucuuaauca cacccuuaua acaaaaaccu gcauauuuuu    17760

ucuuuuuaaa gaaugaaaau gaaagccaag uuucaacaga ugaaagugag aacuccaggu    17820

cuccuggaaa uaaaucagau aacaucaagc ccaaaucugc uccauggaac ucuuuucucc    17880

cuccaccacc ccccaugcca gggccaagac ugggaccagg aaagguaaac cuucuaugaa    17940

aguuuuccag aaaauaguua augucgggac auuuaaccuc ucuguuaacu aauuuguagc    18000

ucucccauga aacuuuugua gcuuaaauac acaagaauuu uuugaaaagg aaauaagaua    18060

augaugcaaa auaguuaauu uuuuaaaaaa auguuagaca cugcagugga ugcaacaaaa    18120

uacuuuauau gaaagauuua uccaguuaac uuuuguggag uauuagguau uagacuaaua    18180

auuagcacac uuacuuaagu uagaaaguau aauaaugcgc cggacgcggu agcucacgcc    18240

uguaauccca gcacuuuggg aggccaaggu gggcggauca caaggucagg agaucgagac    18300

cauccuggcu aacacgguga aaccccaucu cuacugaaaa uacaaaaaaa uuugccgggc    18360

gugauggcgg gcaccuguag ucccagcuac ucgggaggcu gaggcaggag gaugguguga    18420

accccggagg cagagcuugc agugagucaa gaucgugcca cugcacucca accugggcga    18480

cagaaugaga cuccaucuca aacaaaaaaa caaaacaaaa caaaaaaaag uguaauaaua    18540

auuuaucauu agcuggauga uaugcuguug uuucccaugu caccuguaua agauauguaa    18600

aauaagaaca cauuauuuac aucuaauaua gauaaaaucc ugaggcgcuc ucagauuguu    18660

uuguagaguu caaauguaaa uauuguuuuc auuuaugguc cuuuugguua uaaguaacag    18720

aaaucaacuc uaaaaagauu uuuauuauag guuagauuau gucauggaac cuuaaggcuu    18780

gucccuuucu aguucuuuug uguaaagcgg ugauuucuuc cauggaggga augguauuua    18840

ggcaauuuuu uuuuuuuuuu cgagauggag ucuugcucug ucgcucaggc uggagugcag    18900

uggcaccauu ucagcucacu gcaacuucca ccuccugggu ucaagugauu cuccugcuuc    18960

agccucccaa guagcugaga uuacaggcac ccgccaccac acccggcuua uuuuguauuu    19020

uuaguagaga ugggguuuca ccauguuggc caggcugguc uugaacuccu gaccucaagu    19080

gaucucccca ccuuggccuu ccaaagugcu aggauuacag gcgccuagcc uaggcaguca    19140

uuuucaaaaa acaagcauga cucaccaaaa guuuuaagau uuucugugau aauguucuua    19200

uugaggcuua cauuauauua caguuucuug aaucuaaaau gauguacccu cuuagaauau    19260

auacaucaug cuucauuggu cucagggggc ugauuuuuau aaggagagau uugcuaguuu    19320

ucacaauaug uccucuaagu uggcauguau agcuaaacag gcuuucauaa aaauauacaa    19380

uuuaguuaau gaaauuuggg auauagucuu uuaugauuga aauaauuuug cuaaauagac    19440

ugucucugau uuauuaggua aucaccacuc uuauuuuguu uuacuuccuu aaugucuaca    19500

uagaaaggaa augagaaaaa uccagagguu gucauuugac uuaugagucu guuugacuuc    19560

aggauuuggu acaugaaauu ucacuuaauc uuuuugauau guauaaaaca aauauucugg    19620

guaauuauuu uuauccuuuu gguuuugagu ccuuuuuauu ccuaucauau ugaaauuggu    19680

aaguuaauuu uccuuugaaa uauuccuuau agccaggucu aaaauucaau ggcccaccac    19740

cgccaccgcc accaccacca ccccacuuac uaucaugcug gcugccucca uuuccuucug    19800

gaccaccagu aaguaaaaaa gaguauaggu uagauuuugc uuucacauac aauuugauaa    19860

uuagcagaau agaggauugu aaaaugucau uguagaacau cccuugggcc agauucuaau    19920

ggguagaaau uugaacuaaa ccucuggguu uuguuuguuu uuaaugccuu ucuguuaccc    19980

agaugcagug cucuuguagu cccaagucua agcucuaggu ugccuucuuu ccuggcagaa    20040

guuggugucu augccauaag gagguaguuc cuguuagaag ggauuuaauu auaccuuaua    20100

uaaggaauua guguuugccc uucuagguau aguuggaugu uagcuucuga uguaaacugg    20160

auuucuuuuu cuuucucucu cuuuuuuuuu uuuuguuuug gaggcagagu uuugcccuug    20220

uaccccaggc uggagugcag uggugugauc ucagcucaca gcaaccuccg ccuccugggu    20280

ucaagcaauu cugccucggc cucccaagua gcugggauua caggcgacug ccaccacacc    20340

cggcuaauuu uuguuuuauu aguagagaug ggguuucacc auguuggcca gacugaucuu    20400

gaacuccuga ccucagguga uccacccgcc uuggccuccc aaagcgcugg gauuacaggc    20460

gugagcugcc gcacccagcu guaaacugga uuucuaaugg uagauuuuua gguauuaaca    20520

auagauaaaa agauacuuuu uggcauacug uguauuggga ugggguuaga acagguguuc    20580

uacccaagac auuuacuuaa aaucgcccuc gaaaugcuau gugagcugug ugugugugug    20640

ugugugugug uguauuaagg aaaagcauga aaguauuuau gcuugauuuu uuuuuuuuac    20700

ucauagcuuc auaguggaac agauacauag ucuaaaucaa aauguuuaaa cuuuuuaugu    20760

cacuugcugu cuuuucgucc ucguuaaauu uaauuuuguu ggucuuuugu uguuauuggu    20820

ugguuuucuc caaaugcuag cuauguuaag aaauuuaagg ccagguacag uggcucaugc    20880

cuguaauccc ggcauuuuag aaggcugagg caggaggauc acuugagcuc aggaguuuga    20940

gaccagucug ggcaacauag caagaccucg ucuuuguuua ggggaaaaaa aagaaauuua    21000

aguaggagau uauauaagca aaaauacaau uaauuuccag cauucacuau auaauauaaa    21060

ucuccagacu uuacuuuuuu guuuacugga uauaaacaau aucuuuuucu gucuccagau    21120

aauuccccca ccaccuccca uauguccaga uucucuugau gaugcugaug cuuugggaag    21180

uauguuaauu ucaugguaca ugaguggcua ucauacuggc uauuauaugg uaaguaauca    21240

cucagcaucu uuuccugaca auuuuuuugu aguuauguga cuuuguuuug uaaauuuaua    21300

aaauacuacu ugcuucucuc uuuauauuac uaaaaaauaa aaauaaaaaa auacaacugu    21360

cugaggcuua aauuacucuu gcauuguccc uaaguauaau uuuaguuaau uuuaaaaagc    21420

uuucaugcua uuguuagauu auuuugauua uacacuuuug aauugaaauu auacuuuuuc    21480

uaaauaaugu uuuaaucucu gauuugaaau ugauuguagg gaauggaaaa gaugggauaa    21540

uuuuucauaa augaaaaaug aaauucuuuu uuuuuuuuuu uuuuuuuuga gacggagucu    21600

ugcucuguug cccaggcugg agugcaaugg cgugaucuug gcucacagca agcucugccu    21660

ccuggauuca cgccauucuc cugccucagc cucagaggua gcugggacua caggugccug    21720

ccaccacgcc ugucuaauuu uuuguauuuu uuuguaaaga caggguuuca cuguguuagc    21780

caggaugguc ucaaucuccu gaccccguga uccacccgcc ucggccuucc aagagaaaug    21840

aaauuuuuuu aaugcacaaa gaucuggggu aauguguacc acauugaacc uuggggagua    21900

uggcuucaaa cuugucacuu uauacguuag ucuccuacgg acauguucua uuguauuuua    21960

gucagaacau uuaaaauuau uuuauuuuau uuuauuuuuu uuuuuuuuuu gagacggagu    22020

cucgcucugu cacccaggcu ggaguacagu ggcgcagucu cggcucacug caagcuccgc    22080

cucccggguu cacgccauuc uccugccuca gccucuccga guagcuggga cuacaggcgc    22140

ccgccaccac gcccggcuaa uuuuuuuuua uuuuuaguag agacgggguu ucaccguggu    22200

cucgaucucc ugaccucgug auccacccgc cucggccucc caaagugcug ggauuacaag    22260

cgugagccac cgcgcccggc cuaaaauuau uuuuaaaagu aagcucuugu gcccugcuaa    22320

aauuaugaug ugauauugua ggcacuugua uuuuuaguaa auuaauauag aagaaacaac    22380

ugacuuaaag guguauguuu uuaaauguau caucugugug ugcccccauu aauauucuua    22440

uuuaaaaguu aaggccagac augguggcuu acaacuguaa ucccaacagu uugugaggcc    22500

gaggcaggca gaucacuuga ggucaggagu uugagaccag ccuggccaac augaugaaac    22560

cuugucucua cuaaaaauac caaaaaaaau uuagccaggc augguggcac augccuguaa    22620

uccgagcuac uugggaggcu guggcaggaa aauugcuuua aucugggagg cagagguugc    22680

agugaguuga gauugugcca cugcacucca cccuugguga cagagugaga uuccaucuca    22740

aaaaaagaaa aaggccuggc acgguggcuc acaccuauaa ucccaguacu uugggaggua    22800

gaggcaggug gaucacuuga gguuaggagu ucaggaccag ccuggccaac auggugacua    22860

cuccauuucu acuaaauaca caaaacuuag cccaguggcg ggcaguugua aucccagcua    22920

cuugagaggu ugaggcagga gaaucacuug aaccugggag gcagagguug cagugagccg    22980

agaucacacc gcugcacucu agccuggcca acagagugag aauuugcgga gggaaaaaaa    23040

agucacgcuu caguuguugu aguauaaccu ugguauauug uauguaucau gaauuccuca    23100

uuuuaaugac caaaaaguaa uaaaucaaca gcuuguaauu uguuuugaga ucaguuaucu    23160

gacuguaaca cuguaggcuu uuguguuuuu uaaauuauga aauauuugaa aaaaauacau    23220

aauguauaua uaaaguauug guauaauuua uguucuaaau aacuuucuug agaaauaauu    23280

cacauggugu gcaguuuacc uuugaaagua uacaaguugg cugggcacaa uggcucacgc    23340

cuguaauccc agcacuuugg gaggccaggg cagguggauc acgaggucag gagaucgaga    23400

ccauccuggc uaacauggug aaaccccguc ucuacuaaaa guacaaaaac aaauuagccg    23460

ggcauguugg cgggcaccuu uugucccagc ugcucgggag gcugaggcag gagaguggcg    23520

ugaacccagg agguggagcu ugcagugagc cgagauugug ccagugcacu ccagccuggg    23580

cgacagagcg agacucuguc ucaaaaaaua aaauaaaaaa gaaaguauac aagucagugg    23640

uuuugguuuu caguuaugca accaucacua caauuuaaga acauuuucau caccccaaaa    23700

agaaacccug uuaccuucau uuuccccagc ccuaggcagu caguacacuu ucugucucua    23760

ugaauuuguc uauuuuagau auuauauaua aacggaauua uacgauaugu ggucuuuugu    23820

gucuggcuuc uuucacuuag caugcuauuu ucaagauuca uccaugcugu agaaugcacc    23880

aguacugcau uccuucuuau ugcugaauau ucuguuguuu gguuauauca cauuuuaucc    23940

auucaucagu ucauggacau uuagguuguu uuuauuuuug ggcuauaaug aauaauguug    24000

cuaugaacau ucguuugugu ucuuuuuguu uuuuugguuu uuuggguuuu uuuuguuuug    24060

uuuuuguuuu ugagacaguc uugcucuguc uccuaagcug gagugcagug gcaugaucuu    24120

ggcuuacugc aagcucugcc ucccggguuc acaccauucu ccugccucag cccgacaagu    24180

agcugggacu acaggcgugu gccaccaugc acggcuaauu uuuuguauuu uuaguagaga    24240

ugggguuuca ccguguuagc caggaugguc ucgaucuccu gaccucguga ucugccugcc    24300

uaggccuccc aaagugcugg gauuacaggc gugagccacu gcaccuggcc uuaaguguuu    24360

uuaauacguc auugccuuaa gcuaacaauu cuuaaccuuu guucuacuga agccacgugg    24420

uugagauagg cucugagucu agcuuuuaac cucuaucuuu uugucuuaga aaucuaagca    24480

gaaugcaaau gacuaagaau aauguuguug aaauaacaua aaauagguua uaacuuugau    24540

acucauuagu aacaaaucuu ucaauacauc uuacggucug uuagguguag auuaguaaug    24600

aagugggaag ccacugcaag cuaguauaca uguagggaaa gauagaaagc auugaagcca    24660

gaagagagac agaggacauu ugggcuagau cugacaagaa aaacaaaugu uuuaguauua    24720

auuuuugacu uuaaauuuuu uuuuuauuua gugaauacug guguuuaaug gucucauuuu    24780

aauaaguaug acacagguag uuuaagguca uauauuuuau uugaugaaaa uaagguauag    24840

gccgggcacg guggcucaca ccuguaaucc cagcacuuug ggaggccgag gcaggcggau    24900

caccugaggu cgggaguuag agacuagccu caacauggag aaaccccguc ucuacuaaaa    24960

aaaauacaaa auuaggcggg cgugguggug caugccugua aucccagcua cucaggaggc    25020

ugaggcagga gaauugcuug aaccugggag guggagguug cggugagccg agaucaccuc    25080

auugcacucc agccugggca acaagagcaa aacuccaucu caaaaaaaaa aaaauaaggu    25140

auaagcgggc ucaggaacau cauuggacau acugaaagaa gaaaaaucag cugggcgcag    25200

uggcucacgc cgguaauccc aacacuuugg gaggccaagg caggcgaauc accugaaguc    25260

gggaguucca gaucagccug accaacaugg agaaacccug ucucuacuaa aaauacaaaa    25320

cuagccgggc augguggcgc augccuguaa ucccagcuac uugggaggcu gaggcaggag    25380

aauugcuuga accgagaagg cggagguugc ggugagccaa gauugcacca uugcacucca    25440

gccugggcaa caagagcgaa acuccgucuc aaaaaaaaaa ggaagaaaaa uauuuuuuua    25500

aauuaauuag uuuauuuauu uuuuaagaug gaguuuugcc cugucaccca ggcuggggug    25560

caauggugca aucucggcuc acugcaaccu ccgccuccug gguucaagug auucuccugc    25620

cucagcuucc cgaguagcug ugauuacagc cauaugccac cacgcccagc caguuuugug    25680

uuuuguuuug uuuuuuguuu uuuuuuuuug agaggguguc uugcucuguc ccccaagcug    25740

gagugcagcg gcgcgaucuu ggcucacugc aagcucugcc ucccagguuc acaccauucu    25800

cuugccucag ccucccgagu agcugggacu acaggugccc gccaccacac ccggcuaauu    25860

uuuuuguguu uuuaguagag augggguuuc acuguguuag ccaggauggu cucgaucucc    25920

ugaccuuuug auccacccgc cucagccucc ccaagugcug ggauuauagg cgugagccac    25980

ugugcccggc cuagucuugu auuuuuagua gagucgggau uucuccaugu uggucaggcu    26040

guucuccaaa uccgaccuca ggugauccgc ccgccuuggc cuccaaaagu gcaaggcaag    26100

gcauuacagg caugagccac ugugaccggc aauguuuuua aauuuuuuac auuuaaauuu    26160

uauuuuuuag agaccagguc ucacucuauu gcucaggcug gagugcaagg gcacauucac    26220

agcucacugc agccuugacc uccagggcuc aagcaguccu cucaccucag uuucccgagu    26280

agcugggacu acagugauaa ugccacugca ccuggcuaau uuuuauuuuu auuuauuuau    26340

uuuuuuuuga gacagagucu ugcucuguca cccaggcugg agugcagugg uguaaaucuc    26400

agcucacugc agccuccgcc uccuggguuc aagugauucu ccugccucaa ccucccaagu    26460

agcugggauu agaggucccc accaccaugc cuggcuaauu uuuuguacuu ucaguagaaa    26520

cgggguuuug ccauguuggc caggcuguuc ucgaacuccu gagcucaggu gauccaacug    26580

ucucggccuc ccaaagugcu gggauuacag gcgugagcca cugugccuag ccugagccac    26640

cacgccggcc uaauuuuuaa auuuuuugua gagacagggu cucauuaugu ugcccagggu    26700

ggugucaagc uccaggucuc aagugauccc ccuaccuccg ccucccaaag uugugggauu    26760

guaggcauga gccacugcaa gaaaaccuua acugcagccu aauaauuguu uucuuuggga    26820

uaacuuuuaa aguacauuaa aagacuauca acuuaauuuc ugaucauauu uuguugaaua    26880

aaauaaguaa aaugucuugu gaaacaaaau gcuuuuuaac auccauauaa agcuaucuau    26940

auauagcuau cuauaucuau auagcuauuu uuuuuaacuu ccuuuauuuu ccuuacaggg    27000

uuuuagacaa aaucaaaaag aaggaaggug cucacauucc uuaaauuaag gaguaagucu    27060

gccagcauua ugaaagugaa ucuuacuuuu guaaaacuuu augguuugug gaaaacaaau    27120

guuuuugaac auuuaaaaag uucagauguu agaaaguuga aagguuaaug uaaaacaauc    27180

aauauuaaag aauuuugaug ccaaaacuau uagauaaaag guuaaucuac aucccuacua    27240

gaauucucau acuuaacugg uugguugugu ggaagaaaca uacuuucaca auaaagagcu    27300

uuaggauaug augccauuuu auaucacuag uaggcagacc agcagacuuu uuuuuauugu    27360

gauaugggau aaccuaggca uacugcacug uacacucuga cauaugaagu gcucuaguca    27420

aguuuaacug guguccacag aggacauggu uuaacuggaa uucgucaagc cucugguucu    27480

aauuucucau uugcaggaaa ugcuggcaua gagcagcacu aaaugacacc acuaaagaaa    27540

cgaucagaca gaucuggaau gugaagcguu auagaagaua acuggccuca uuucuucaaa    27600

auaucaagug uugggaaaga aaaaaggaag uggaaugggu aacucuucuu gauuaaaagu    27660

uauguaauaa ccaaaugcaa ugugaaauau uuuacuggac ucuauuuuga aaaaccaucu    27720

guaaaagacu gagguggggg ugggaggcca gcacgguggu gaggcaguug agaaaauuug    27780

aauguggauu agauuuugaa ugauauugga uaauuauugg uaauuuuaug agcugugaga    27840

aggguguugu aguuuauaaa agacugucuu aauuugcaua cuuaagcauu uaggaaugaa    27900

guguuagagu gucuuaaaau guuucaaaug guuuaacaaa auguauguga ggcguaugug    27960

gcaaaauguu acagaaucua acugguggac auggcuguuc auuguacugu uuuuuucuau    28020

cuucuauaug uuuaaaagua uauaauaaaa auauuuaauu uuuuuuuaaa uua           28073


<210>  65
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  modified by a phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl) modification

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl) modification

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl) modification

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl) modification

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  65
tcactttcat aatgctgg                                                     18


<210>  66
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  modified a phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl) modification

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl) modification

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl) modification

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  modified by phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  modified by phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl) modification

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  66
tcactttcat aatgctgg                                                     18


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  modified by phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 5' methyl C with moe modification

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 5' methyl C with moe modification

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 5' methyl C with moe modification

<220>
<221>  misc_feature
<222>  (8)..(15)
<223>  modified by phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 5' methyl C with moe modification

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by 5' methyl C with moe modification

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  67
tcactttcat aatgctgg                                                     18


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  modified by phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 5' methyl C with moe modification

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 5' methyl C with moe modification

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (8)..(15)
<223>  modified by phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 5' methyl C with moe modification

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 5' methyl C with moe modification

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  68
tcactttcat aatgctgg                                                     18


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 5'-Cholesteryl-tetraethylene glycol and 2 internal 
       hexaethylenegylcol spacers and 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  modified by 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 5' methyl C with 2'-O-(2-methoxyethyl)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by 2'-O-(2-methoxyethyl)

<400>  69
tcactttcat aatgctgg                                                     18


<210>  70
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modified by 2'-O-methyl and phosphorothioate internucleotide 
       linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  70
ucacuuucau aaugcugg                                                     18


<210>  71
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  71
ucacuuucau aaugcugg                                                     18


<210>  72
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 5' methyl C with 2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 5' methyl C with 2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 5' methyl C with 2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 5' methyl C with 2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  72
tcactttcat aatgctgg                                                     18


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 5' methyl C with 2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 5' methyl C with 2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 5' methyl C with 2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  modified by 2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 5' methyl C with 2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by 2'-O-methyl

<400>  73
tcactttcat cctgctgg                                                     18


<210>  74
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modifed by 2'-O-methyl

<400>  74
ucacuuucau aaugcugg                                                     18


<210>  75
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modified by morpholino sugar modification

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by CholEG

<400>  75
tcactttcat aatgctgg                                                     18


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modified by CholEG

<400>  76
tcactttcat aatgctgg                                                     18


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'-O,4'-C-ethylene-bridged sugar modification

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 5' methyl C with 2'-O,4'-C-ethylene-bridged sugar 
       modification

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'-O,4'-C-ethylene-bridged sugar modification

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 5' methyl C with 2'-O,4'-C-ethylene-bridged sugar 
       modification

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  modified by 2'-O,4'-C-ethylene-bridged sugar modification

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 5' methyl C with 2'-O,4'-C-ethylene-bridged sugar 
       modification

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  modified by 2'-O,4'-C-ethylene-bridged sugar modification

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 5' methyl C with 2'-O,4'-C-ethylene-bridged sugar 
       modification

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by 2'-O,4'-C-ethylene-bridged sugar modification

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  77
tcactttcat aatgctgg                                                     18


<210>  78
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  78
tcactttcat aatgctgg                                                     18


<210>  79
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  79
tcactttcat aatgctgg                                                     18


<210>  80
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  80
tcactttcat aatgctgg                                                     18


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  81
gtactacact tttaattact                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  82
tgtatattga tgtcagtact                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  83
tacattgtct attagtgtat                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  84
tgactctcaa ttctgttaca                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  85
tcacagggct atttctgact                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  86
aatcagtcac atatatcaca                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  87
tgtaacttta gttaaaatca                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  88
ctattaaacc acatttgtaa                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  89
actactatgc tttctctatt                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  90
ccaccatttc ttgaaactac                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  91
tttccaatag ttttaccacc                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  92
gtttttgcat aaggatttcc                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  93
gtggaaattt ggtttgtttt                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  94
tgtggctcag tgtaggtgga                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  95
gtattaattc ttatatgtgg                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  96
ttagttttac acttaggtct                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  97
acacagttta gagttttagt                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  98
gatcacagat ttttctctct                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  99
ttataggcaa tccatgatca                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  100
catttcagtt tgttcttttg                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  101
cccaggcaac aaggccattt                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  102
gaacctcggg tgccacccca                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  103
cgtccttgat ttcctcagcg                                                   20


<210>  104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  104
acacccttgg tgtgtcagcg                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  105
ttctgctcta gcctcacacc                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  106
ggagagagct agtctctttc                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  107
aggacctctc tctgcaggag                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  108
atgggaactc ttttcaggac                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  109
gcatttcact gtggaatggg                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  110
tttataaaaa tgcttgcatt                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  111
cttcccatta gctcatttat                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  112
tagataagct acccccttcc                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  113
tttgctccct atgtgtagat                                                   20


<210>  114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  114
ggtcctaact ggttttttgc                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  115
cagatggcaa cacctggtcc                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  116
gattcacgct ctgtgcagat                                                   20


<210>  117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  117
gcctgcataa taaaaggttg                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  118
tcaggccaag gacctgcctg                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  119
taagcaatgt ggagtagctc                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  120
acaataggaa agagataagc                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  121
ttatttagca catgcacaat                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  122
tggctccacc tccccttatt                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  123
gcatgtccac catggtggct                                                   20


<210>  124
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  124
agctgcacgg agagaaaggg                                                   20


<210>  125
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  125
gcatgttgtg agttgttggg                                                   20


<210>  126
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  126
tcagataagg aagctggaag                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  127
gaccttagta catactcaga                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  128
gaagtaaaca cagtggacct                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  129
gtatgtgaag taaacacagt                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  130
gtaaacacag tatgtgaagt                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  131
aggtgggtat gtgaagtaaa                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  132
atcagcaagc ttcacatacg                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  133
ggagcttcct gggtaatcag                                                   20


<210>  134
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  134
agcagctctg gcacagaggg                                                   20


<210>  135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  135
aaacatgtat aaggaagcag                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  136
ggaagatcgg gctgtaaaca                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  137
acttctcttc taacaaggag                                                   20


<210>  138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  138
cagagtcctc ggtagaactt                                                   20


<210>  139
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  139
aagccgatag ttagacagag                                                   20


<210>  140
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  140
aaaaaaagac taggtaagcc                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  141
gttttgagag aggaggtaaa                                                   20


<210>  142
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  142
gttttttctt tgatggtttt                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  143
gaaatctaat ttttcagttt                                                   20


<210>  144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  144
aatcttaatt ttgctgaaat                                                   20


<210>  145
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  145
tttttaagaa cagaaaatct                                                   20


<210>  146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  146
acactttggt ttttcatttt                                                   20


<210>  147
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  147
attttctccc ggtttacact                                                   20


<210>  148
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  148
aggtaacttg catgtatttt                                                   20


<210>  149
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  149
aatatcttta tcagataggt                                                   20


<210>  150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  150
atgtttgctg ggtacaatat                                                   20


<210>  151
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  151
gtttgagagt tcttcatgtt                                                   20


<210>  152
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  152
catcttttaa ttgaattttt                                                   20


<210>  153
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  153
cccggccaac ttacccatct                                                   20


<210>  154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  154
gattgggatt gcaagtatga                                                   20


<210>  155
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  155
gagcacacgc cacaatgcct                                                   20


<210>  156
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  156
agtcttcttg tctcagcctt                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  157
ccacctcctg cgctcagtct                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacers and 
       3'-Cholesteryl-tetraethylene glycol

<400>  158
tcacacagcc tactgcagcc                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  modified by phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (2)..(6)
<223>  modified by phosphodiester internucleotide linkages

<220>
<221>  misc_feature
<222>  (6)..(16)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by phosphodiester internucleotide linkages

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacer and 
       3'-Cholesteryl-tetraethylene glycol

<400>  159
cagagtcctc ggtagaactt                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (2)..(6)
<223>  modified by phosphodiester internucleotide linkages

<220>
<221>  misc_feature
<222>  (6)..(16)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified by phosphodiester internucleotide linkages

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  modified by phosphorothioate internucleotide linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2 internal hexaethylenegylcol spacer and 
       3'-Cholesteryl-tetraethylene glycol

<400>  160
gaaatctaat ttttcagttt                                                   20


<210>  161
<211>  1613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  161
agtaattaaa agtgtagtac tgacatcaat atacactaat agacaatgta acagaattga       60

gagtcagaaa tagccctgtg atatatgtga ctgattttaa ctaaagttac aaatgtggtt      120

taatagagaa agcatagtag tttcaagaaa tggtggtaaa actattggaa atccttatgc      180

aaaaacaaac caaatttcca cctacactga gccacatata agaattaata caaaatggat      240

tacagaccta agtgtaaaac taaaactcta aactgtgtaa aaaaaaaaaa gagagaaaaa      300

tctgtgatca tggattgcct ataacaaaag aacaaactga aatggccttg ttgcctgggg      360

tggcacccga ggttcttggt ctcacgctga ggaaatcaag gacgctgaca caccaagggt      420

gtgaggctag agcagaagtt taataggcaa aagaaagaga ctagctctct cctgcagaga      480

gaggtcctga aaagagttcc cattccacag tgaaatgcaa gcatttttat aaatgagcta      540

atgggaaggg ggtagcttat ctacacatag ggagcaaaaa accagttagg accaggtgtt      600

gccatctgca cagagcgtga atctctggca tcccccaccc caacctttta ttatgcaggc      660

aggtccttgg cctgagctac tccacattgc ttatctcttt cctattgtgc atgtgctaaa      720

taaggggagg tggagccacc atggtggaca tgcctggccc caggtacccc tttctctccg      780

tgcagctgca ggcaacccca acaactcaca acatgcaagc ttccagcttc cttatctgag      840

tatgtactaa ggtccactgt gtttacttca catactgtgt ttacttcaca tacccacctt      900

acgtatgtga agcttgctga ttacccagga agctccccct ctgtgccaga gctgcttcct      960

tatacatgtt tacagcccga tcttccaggc tgctccttgt tagaagagaa gtgatttctt     1020

gggctgcttt ttgttagaag ggaagttcta ccgaggactc tgtctaacta tcggcttacc     1080

tagtcttttt ttacctcctc tctcaaaacc atcaaagaaa aaactgaaaa attagatttc     1140

agcaaaatta agattttctg ttcttaaaaa gacgttgtta acaaaatgaa aaaccaaagt     1200

gtaaaccggg agaaaataca tgcaagttac ctatctgata aagatattgt acccagcaaa     1260

catgaagaac tctcaaacct caacaacaaa aaaattcaat taaaagatgg gtaagttggc     1320

cgggtgcagt ggctcatact tgcaatccca atctttggga ggctgaggca ggaagattgc     1380

ttgagcccag gagttcacga caagcccagg caacataatg agaccttgtt tctacaaaat     1440

tttaaaaaat tagccaggca ttgtggcgtg tgctcgtaat ttcagctact cagaaggctg     1500

agacaagaag actgagcgca ggaggtggag gctgcagtag gctgtgtgat tgcaccactg     1560

cacaacagcc tgggtgacag agtgagacac tgtctccaaa aaaaaaaaaa aaa            1613


