                         SEQUENCE LISTING

<110>  The United States of America, as Represented by the 
       Secretary, Department of Health and Human Services
 
<120>  NEUTRALIZING ANTIBODIES TO HIV-1 ENV AND THEIR USE

<130>  4239-100010-03

<150>  US 62/633,517
<151>  2018-02-21

<150>  US 62/775,754
<151>  2018-12-05

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  1

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  2
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  2

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  3
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120     


<210>  4
<211>  104
<212>  PRT
<213>  homo sapiens

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210>  5
<211>  125
<212>  PRT
<213>  homo sapiens

<400>  5

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg Gly Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Ser Glu Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Asp Phe 
            100                 105                 110         


Glu His Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120                 125 


<210>  6
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  6

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg His Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Ser Glu Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Asp Phe 
            100                 105                 110         


Glu His Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120                 125 


<210>  7
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  7

Ser Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr 
1               5                   10                  15      


Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser 
        35                  40                  45              


Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly 
    50                  55                  60                  


Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly 
65                  70                  75                  80  


Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val 
                85                  90                  95      


Gln Val Asp Ile Lys 
            100     


<210>  8
<211>  123
<212>  PRT
<213>  homo sapiens

<400>  8

Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  9
<211>  99
<212>  PRT
<213>  homo sapiens

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Ile Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Val Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys 
            


<210>  10
<211>  131
<212>  PRT
<213>  homo sapiens

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Pro Val Met Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Ala Thr Ser Gly Tyr Asn Phe Arg Asp Phe 
            20                  25                  30          


Ser Ile His Trp Val Arg Phe Asn Arg Arg Tyr Gly Phe Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Lys Pro Met Trp Gly Ala Val Asn Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Ser Arg Leu Phe Ser Gln Asp Leu Tyr Tyr 
65                  70                  75                  80  


Pro Asp Arg Gly Thr Ala Tyr Leu Glu Phe Ser Gly Leu Thr Ser Ala 
                85                  90                  95      


Asp Thr Ala Asp Tyr Phe Cys Val Arg Arg Gly Ser Ser Cys Pro His 
            100                 105                 110         


Cys Gly Asp Phe His Phe Glu His Trp Gly Gln Gly Thr Ala Val Val 
        115                 120                 125             


Val Ser Ala 
    130     


<210>  11
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Gly Asn Ser Leu 
            20                  25                  30          


Asn Trp Tyr Gln Lys Arg Arg Gly Gln Thr Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Arg Arg Ala Ser Asp Ile Pro Glu Lys Phe Val Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Thr Lys Val Gly Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Glu Phe Phe Gly Leu Gly 
                85                  90                  95      


Thr Thr Leu Glu Ile Asn 
            100         


<210>  12
<211>  130
<212>  PRT
<213>  homo sapiens

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Val Ile Lys Thr Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Asn Phe Arg Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Leu Ile Pro Asp Lys Gly Phe Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Trp Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Val Ala Tyr Met Glu Phe Ser Gly Leu Thr Ser Ala 
                85                  90                  95      


Asp Thr Ala Glu Tyr Phe Cys Val Arg Arg Gly Ser Cys Asp Tyr Cys 
            100                 105                 110         


Gly Asp Phe Pro Trp Gln Tyr Trp Gly Gln Gly Thr Trp Val Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  13
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Phe Cys Lys Ala Ser Gln Gly Gly Asn Ala Met 
            20                  25                  30          


Thr Trp Tyr Gln Lys Arg Arg Gly Gln Val Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Arg Arg Ala Ser Gly Val Pro Asp Arg Phe Val Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Phe Leu Thr Ile Asn Lys Leu Asp Arg Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Glu Phe Phe Gly Leu Gly 
                85                  90                  95      


Ser Glu Leu Glu Val His 
            100         


<210>  14
<211>  111
<212>  PRT
<213>  homo sapiens

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Cys Gly Gly Asp Cys Tyr Asn Trp Phe Asp Ser 
            100                 105                 110     


<210>  15
<211>  97
<212>  PRT
<213>  homo sapiens

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 
                85                  90                  95      


Thr 
    


<210>  16
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  16

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Ile Ala Tyr Met Asp Ile Arg Gly Leu Lys Pro Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Ser Tyr Gly Asp Ser 
            100                 105                 110         


Ser Trp Ala Leu Asp Ala Trp Gly Gln Gly Thr Thr Val Val Val Ser 
        115                 120                 125             


Ala 
    


<210>  17
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn 
            100                 105                 110         


Trp Asp Phe Glu His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120                 125             


<210>  18
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  18

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg Gly Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Thr Arg Gly Lys Tyr Cys Thr Ala Arg 
            100                 105                 110         


Asp Tyr Tyr Asn Trp Asp Phe Glu His Trp Gly Gln Gly Thr Pro Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  19
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  19

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg His Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Thr Arg Gly Lys Tyr Cys Thr Ala Arg 
            100                 105                 110         


Asp Tyr Tyr Asn Trp Asp Phe Glu His Trp Gly Gln Gly Thr Pro Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  20

Ala His Ile Leu Phe 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  21

Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  22

Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala 
1               5                   10              


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  23

Gln Thr Ser Gln Gly Val Gly Ser Asp Leu His 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  24

His Thr Ser Ser Val Glu Asp 
1               5           


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  25

Gln Val Leu Gln Phe 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  26

Asp Cys Thr Leu Asn 
1               5   


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  27

Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  28

Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His 
1               5                   10          


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  29

Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
1               5                   


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  30

Ser Gly Ser Thr Arg Ala Ala 
1               5           


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  31

Gln Gln Tyr Glu Phe 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  32

Asn Cys Pro Ile Asn 
1               5   


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  33

Trp Met Lys Pro Arg Gly Gly Ala Val Ser Tyr Ala Arg Gln Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  34

Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Asp Phe Glu His 
1               5                   10                  15      


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  35

Trp Met Lys Pro Arg His Gly Ala Val Ser Tyr Ala Arg Gln Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  36

Gln Leu Ser Gln Asp Pro Asp Asp Pro Asp Trp Gly 
1               5                   10          


<210>  37
<211>  856
<212>  PRT
<213>  human immunodeficiency virus

<400>  37

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys 
            180                 185                 190         


Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
305                 310                 315                 320 


Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
    450                 455                 460                 


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 
    610                 615                 620                 


His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
625                 630                 635                 640 


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            660                 665                 670         


Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
705                 710                 715                 720 


Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser 
            740                 745                 750         


Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu 
    770                 775                 780                 


Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu 
785                 790                 795                 800 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
                805                 810                 815     


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val 
            820                 825                 830         


Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Leu Glu Arg Ile Leu Leu 
    850                 855     


<210>  38
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  38

Cys Gly Ala Gly Cys Gly Cys Ala Cys Cys Thr Gly Gly Thr Ala Cys 
1               5                   10                  15      


Ala Ala Thr Cys Ala Gly Gly Gly Ala Cys Thr Gly Cys Gly Ala Thr 
            20                  25                  30          


Gly Ala Ala Gly Ala Ala Ala Cys Cys Gly Gly Gly Gly Gly Cys Cys 
        35                  40                  45              


Thr Cys Ala Gly Thr Ala Ala Gly Ala Gly Thr Cys Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Cys Ala Gly Ala Cys Cys Thr Cys Thr Gly Gly Ala Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Thr Ala Cys Cys Gly Cys Cys Cys Ala Cys 
                85                  90                  95      


Ala Thr Ala Thr Thr Ala Thr Thr Thr Thr Gly Gly Thr Thr Cys Cys 
            100                 105                 110         


Gly Ala Cys Ala Gly Gly Cys Cys Cys Cys Cys Gly Gly Gly Cys Gly 
        115                 120                 125             


Ala Gly Gly Ala Cys Thr Thr Gly Ala Gly Thr Gly Gly Gly Thr Gly 
    130                 135                 140                 


Gly Gly Gly Thr Gly Gly Ala Thr Cys Ala Ala Gly Cys Cys Ala Cys 
145                 150                 155                 160 


Ala Ala Thr Ala Thr Gly Gly Gly Gly Cys Cys Gly Thr Gly Ala Ala 
                165                 170                 175     


Thr Thr Thr Thr Gly Gly Thr Gly Gly Thr Gly Gly Thr Thr Thr Thr 
            180                 185                 190         


Cys Gly Gly Gly Ala Cys Ala Gly Gly Gly Thr Cys Ala Cys Ala Thr 
        195                 200                 205             


Thr Gly Ala Cys Thr Cys Gly Ala Cys Ala Ala Thr Thr Ala Thr Cys 
    210                 215                 220                 


Thr Cys Ala Ala Gly Ala Cys Cys Cys Ala Gly Ala Cys Gly Ala Cys 
225                 230                 235                 240 


Cys Cys Gly Gly Ala Cys Thr Gly Gly Gly Gly Cys Ala Thr Thr Gly 
                245                 250                 255     


Cys Gly Thr Ala Cys Ala Thr Gly Gly Ala Cys Ala Thr Cys Ala Gly 
            260                 265                 270         


Ala Gly Gly Cys Cys Thr Thr Ala Ala Ala Cys Cys Thr Gly Ala Cys 
        275                 280                 285             


Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr 
    290                 295                 300                 


Ala Cys Thr Gly Thr Gly Cys Gly Ala Gly Ala Gly Ala Cys Cys Gly 
305                 310                 315                 320 


Thr Thr Cys Cys Thr Ala Thr Gly Gly Cys Gly Ala Cys Thr Cys Cys 
                325                 330                 335     


Thr Cys Thr Thr Gly Gly Gly Cys Cys Thr Thr Ala Gly Ala Thr Gly 
            340                 345                 350         


Cys Cys Thr Gly Gly Gly Gly Ala Cys Ala Gly Gly Gly Ala Ala Cys 
        355                 360                 365             


Gly Ala Cys Gly Gly Thr Cys Gly Thr Cys Gly Thr Cys Thr Cys Cys 
    370                 375                 380                 


Gly Cys Gly 
385         


<210>  39
<211>  309
<212>  PRT
<213>  homo sapiens

<400>  39

Thr Ala Cys Ala Thr Cys Cys Ala Cys Gly Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Cys Cys Gly Thr Cys Cys Thr Cys Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Thr Gly Thr Gly Thr Cys Thr Ala Thr Thr Gly Gly Ala 
        35                  40                  45              


Gly Ala Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala 
    50                  55                  60                  


Ala Thr Thr Gly Cys Cys Ala Gly Ala Cys Gly Ala Gly Thr Cys Ala 
65                  70                  75                  80  


Gly Gly Gly Thr Gly Thr Thr Gly Gly Cys Ala Gly Thr Gly Ala Cys 
                85                  90                  95      


Cys Thr Ala Cys Ala Thr Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys 
            100                 105                 110         


Ala Cys Ala Ala Ala Cys Cys Gly Gly Gly Gly Ala Gly Ala Gly Cys 
        115                 120                 125             


Cys Cys Cys Thr Ala Ala Ala Cys Thr Cys Thr Thr Gly Ala Thr Cys 
    130                 135                 140                 


Cys Ala Cys Cys Ala Thr Ala Cys Cys Thr Cys Thr Thr Cys Thr Gly 
145                 150                 155                 160 


Thr Gly Gly Ala Ala Gly Ala Cys Gly Gly Thr Gly Thr Cys Cys Cys 
                165                 170                 175     


Cys Thr Cys Ala Ala Gly Ala Thr Thr Cys Ala Gly Cys Gly Gly Cys 
            180                 185                 190         


Thr Cys Thr Gly Gly Ala Thr Thr Thr Cys Ala Cys Ala Cys Ala Thr 
        195                 200                 205             


Cys Thr Thr Thr Thr Ala Ala Thr Cys Thr Gly Ala Cys Cys Ala Thr 
    210                 215                 220                 


Cys Ala Gly Cys Gly Ala Cys Cys Thr Ala Cys Ala Gly Gly Cys Thr 
225                 230                 235                 240 


Gly Ala Cys Gly Ala Cys Ala Thr Thr Gly Cys Cys Ala Cys Ala Thr 
                245                 250                 255     


Ala Thr Thr Ala Cys Thr Gly Thr Cys Ala Ala Gly Thr Thr Thr Thr 
            260                 265                 270         


Ala Cys Ala Ala Thr Thr Thr Thr Thr Cys Gly Gly Cys Cys Gly Ala 
        275                 280                 285             


Gly Gly Gly Ala Gly Thr Cys Gly Ala Cys Thr Cys Cys Ala Thr Ala 
    290                 295                 300                 


Thr Thr Ala Ala Ala 
305                 


<210>  40
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  40

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Ala Gly Gly Thr Cys Ala Gly Ala Thr 
            20                  25                  30          


Gly Ala Ala Gly Ala Ala Gly Cys Cys Thr Gly Gly Cys Gly Ala Gly 
        35                  40                  45              


Thr Cys Gly Ala Thr Gly Ala Gly Ala Ala Thr Thr Thr Cys Thr Thr 
    50                  55                  60                  


Gly Thr Cys Gly Gly Gly Cys Thr Thr Cys Thr Gly Gly Ala Thr Ala 
65                  70                  75                  80  


Thr Gly Ala Ala Thr Thr Thr Ala Thr Thr Gly Ala Thr Thr Gly Thr 
                85                  90                  95      


Ala Cys Gly Cys Thr Ala Ala Ala Thr Thr Gly Gly Ala Thr Thr Cys 
            100                 105                 110         


Gly Thr Cys Thr Gly Gly Cys Cys Cys Cys Cys Gly Gly Ala Ala Ala 
        115                 120                 125             


Ala Ala Gly Gly Cys Cys Thr Gly Ala Gly Thr Gly Gly Ala Thr Gly 
    130                 135                 140                 


Gly Gly Ala Thr Gly Gly Cys Thr Gly Ala Ala Gly Cys Cys Thr Cys 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Cys Cys Gly Thr Cys Ala Ala 
                165                 170                 175     


Cys Thr Ala Cys Gly Cys Ala Cys Gly Thr Cys Cys Ala Cys Thr Thr 
            180                 185                 190         


Cys Ala Gly Gly Gly Cys Ala Gly Ala Gly Thr Gly Ala Cys Cys Ala 
        195                 200                 205             


Thr Gly Ala Cys Thr Cys Gly Ala Cys Ala Ala Thr Thr Ala Thr Cys 
    210                 215                 220                 


Thr Cys Ala Ala Gly Ala Cys Cys Cys Ala Gly Ala Cys Gly Ala Cys 
225                 230                 235                 240 


Cys Cys Gly Gly Ala Cys Thr Gly Gly Gly Gly Cys Ala Cys Ala Gly 
                245                 250                 255     


Cys Cys Thr Thr Thr Thr Thr Gly Gly Ala Gly Cys Thr Gly Cys Gly 
            260                 265                 270         


Cys Thr Cys Gly Thr Thr Gly Ala Cys Ala Gly Thr Ala Gly Ala Cys 
        275                 280                 285             


Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys Thr Ala Cys Thr 
    290                 295                 300                 


Thr Thr Thr Gly Thr Ala Cys Thr Ala Gly Gly Gly Gly Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Cys Thr Gly Thr Gly Ala Thr Thr Ala Cys Ala Ala Thr 
                325                 330                 335     


Thr Gly Gly Gly Ala Cys Thr Thr Cys Gly Ala Ala Cys Ala Cys Thr 
            340                 345                 350         


Gly Gly Gly Gly Cys Cys Gly Gly Gly Gly Cys Ala Cys Cys Cys Cys 
        355                 360                 365             


Gly Gly Thr Cys Ala Thr Cys Gly Thr Cys Thr Cys Ala Thr Cys Ala 
    370                 375                 380                 


<210>  41
<211>  309
<212>  PRT
<213>  homo sapiens

<400>  41

Gly Ala Ala Ala Thr Thr Gly Thr Gly Thr Thr Gly Ala Cys Ala Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Cys Cys Ala Gly Gly Cys Ala Cys Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Thr Thr Thr Gly Thr Cys Thr Cys Cys Ala Gly Gly Gly 
        35                  40                  45              


Gly Ala Ala Ala Cys Ala Gly Cys Cys Ala Thr Cys Ala Thr Cys Thr 
    50                  55                  60                  


Cys Thr Thr Gly Thr Cys Gly Gly Ala Cys Cys Ala Gly Thr Cys Ala 
65                  70                  75                  80  


Gly Thr Ala Thr Gly Gly Thr Thr Cys Cys Thr Thr Ala Gly Cys Cys 
                85                  90                  95      


Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys Ala Gly Ala Gly Gly Cys 
            100                 105                 110         


Cys Cys Gly Gly Cys Cys Ala Gly Gly Cys Cys Cys Cys Cys Ala Gly 
        115                 120                 125             


Gly Cys Thr Cys Gly Thr Cys Ala Thr Cys Thr Ala Thr Thr Cys Gly 
    130                 135                 140                 


Gly Gly Cys Thr Cys Thr Ala Cys Thr Cys Gly Gly Gly Cys Cys Gly 
145                 150                 155                 160 


Cys Thr Gly Gly Cys Ala Thr Cys Cys Cys Ala Gly Ala Cys Ala Gly 
                165                 170                 175     


Gly Thr Thr Cys Ala Gly Cys Gly Gly Cys Ala Gly Thr Cys Gly Gly 
            180                 185                 190         


Thr Gly Gly Gly Gly Gly Cys Cys Ala Gly Ala Cys Thr Ala Cys Ala 
        195                 200                 205             


Ala Thr Cys Thr Cys Ala Cys Cys Ala Thr Cys Ala Gly Cys Ala Ala 
    210                 215                 220                 


Cys Cys Thr Gly Gly Ala Gly Thr Cys Gly Gly Gly Ala Gly Ala Thr 
225                 230                 235                 240 


Thr Thr Thr Gly Gly Thr Gly Thr Thr Thr Ala Thr Thr Ala Thr Thr 
                245                 250                 255     


Gly Cys Cys Ala Gly Cys Ala Gly Thr Ala Thr Gly Ala Ala Thr Thr 
            260                 265                 270         


Thr Thr Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Gly Ala Cys Cys 
        275                 280                 285             


Ala Ala Gly Gly Thr Cys Cys Ala Gly Gly Thr Cys Gly Ala Cys Ala 
    290                 295                 300                 


Thr Thr Ala Ala Ala 
305                 


<210>  42
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  42

Cys Ala Gly Gly Thr Gly Cys Gly Ala Cys Thr Gly Thr Cys Gly Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Ala Gly Gly Thr Cys Ala Gly Ala Thr 
            20                  25                  30          


Gly Ala Ala Gly Ala Ala Gly Cys Cys Thr Gly Gly Cys Gly Ala Cys 
        35                  40                  45              


Thr Cys Gly Ala Thr Gly Ala Gly Ala Ala Thr Thr Thr Cys Thr Thr 
    50                  55                  60                  


Gly Thr Cys Gly Gly Gly Cys Thr Thr Cys Gly Gly Gly Ala Thr Ala 
65                  70                  75                  80  


Cys Gly Ala Ala Thr Thr Thr Ala Thr Thr Ala Ala Thr Thr Gly Thr 
                85                  90                  95      


Cys Cys Ala Ala Thr Ala Ala Ala Thr Thr Gly Gly Ala Thr Thr Cys 
            100                 105                 110         


Gly Gly Cys Thr Gly Gly Cys Cys Cys Cys Cys Gly Gly Ala Ala Ala 
        115                 120                 125             


Ala Ala Gly Gly Cys Cys Thr Gly Ala Gly Thr Gly Gly Ala Thr Gly 
    130                 135                 140                 


Gly Gly Ala Thr Gly Gly Ala Thr Gly Ala Ala Gly Cys Cys Thr Ala 
145                 150                 155                 160 


Gly Gly Gly Gly Thr Gly Gly Gly Gly Cys Cys Gly Thr Cys Ala Gly 
                165                 170                 175     


Thr Thr Ala Cys Gly Cys Ala Cys Gly Thr Cys Ala Ala Cys Thr Thr 
            180                 185                 190         


Cys Ala Gly Gly Gly Cys Ala Gly Ala Gly Thr Gly Ala Cys Cys Ala 
        195                 200                 205             


Thr Gly Ala Cys Thr Cys Gly Ala Cys Ala Ala Thr Thr Ala Thr Cys 
    210                 215                 220                 


Thr Cys Ala Ala Gly Ala Cys Cys Cys Ala Gly Ala Cys Gly Ala Cys 
225                 230                 235                 240 


Cys Cys Gly Gly Ala Cys Thr Gly Gly Gly Gly Cys Ala Cys Ala Gly 
                245                 250                 255     


Cys Cys Thr Thr Thr Thr Thr Gly Gly Ala Gly Cys Thr Cys Cys Gly 
            260                 265                 270         


Thr Thr Cys Cys Thr Thr Gly Ala Cys Ala Thr Cys Cys Gly Ala Cys 
        275                 280                 285             


Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr 
    290                 295                 300                 


Thr Thr Thr Gly Thr Ala Cys Thr Cys Gly Gly Gly Gly Ala Ala Ala 
305                 310                 315                 320 


Ala Thr Ala Thr Thr Gly Cys Ala Cys Thr Gly Cys Gly Cys Gly Cys 
                325                 330                 335     


Gly Ala Cys Thr Ala Thr Thr Ala Thr Ala Ala Thr Thr Gly Gly Gly 
            340                 345                 350         


Ala Cys Thr Thr Cys Gly Ala Ala Cys Ala Cys Thr Gly Gly Gly Gly 
        355                 360                 365             


Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Cys Gly Gly Thr Cys 
    370                 375                 380                 


Ala Cys Cys Gly Thr Cys Thr Cys Gly Thr Cys Ala 
385                 390                 395     


<210>  43
<211>  309
<212>  PRT
<213>  homo sapiens

<400>  43

Gly Ala Ala Ala Thr Thr Gly Thr Gly Thr Thr Gly Ala Cys Ala Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Cys Cys Ala Gly Gly Cys Ala Cys Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Thr Thr Thr Gly Thr Cys Thr Cys Cys Ala Gly Gly Gly 
        35                  40                  45              


Gly Ala Ala Ala Cys Ala Gly Cys Cys Ala Thr Cys Ala Thr Cys Thr 
    50                  55                  60                  


Cys Thr Thr Gly Thr Cys Gly Gly Ala Cys Cys Ala Gly Thr Cys Ala 
65                  70                  75                  80  


Gly Thr Ala Thr Gly Gly Thr Thr Cys Cys Thr Thr Ala Gly Cys Cys 
                85                  90                  95      


Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys Ala Gly Ala Gly Gly Cys 
            100                 105                 110         


Cys Cys Gly Gly Cys Cys Ala Gly Gly Cys Cys Cys Cys Cys Ala Gly 
        115                 120                 125             


Gly Cys Thr Cys Gly Thr Cys Ala Thr Cys Thr Ala Thr Thr Cys Gly 
    130                 135                 140                 


Gly Gly Cys Thr Cys Thr Ala Cys Thr Cys Gly Gly Gly Cys Cys Gly 
145                 150                 155                 160 


Cys Thr Gly Gly Cys Ala Thr Cys Cys Cys Ala Gly Ala Cys Ala Gly 
                165                 170                 175     


Gly Thr Thr Cys Ala Gly Cys Gly Gly Cys Ala Gly Thr Cys Gly Gly 
            180                 185                 190         


Thr Gly Gly Gly Gly Gly Cys Cys Ala Gly Ala Cys Thr Ala Cys Ala 
        195                 200                 205             


Ala Thr Cys Thr Cys Ala Cys Cys Ala Thr Cys Ala Gly Cys Ala Ala 
    210                 215                 220                 


Cys Cys Thr Gly Gly Ala Gly Thr Cys Gly Gly Gly Ala Gly Ala Thr 
225                 230                 235                 240 


Thr Thr Thr Gly Gly Thr Gly Thr Thr Thr Ala Thr Thr Ala Thr Thr 
                245                 250                 255     


Gly Cys Cys Ala Gly Cys Ala Gly Thr Ala Thr Gly Ala Ala Thr Thr 
            260                 265                 270         


Thr Thr Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Gly Ala Cys Cys 
        275                 280                 285             


Ala Ala Gly Gly Thr Cys Cys Ala Gly Gly Thr Cys Gly Ala Cys Ala 
    290                 295                 300                 


Thr Thr Ala Ala Ala 
305                 


<210>  44
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  44

Cys Ala Gly Gly Thr Gly Cys Gly Ala Cys Thr Gly Thr Cys Gly Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Ala Gly Gly Thr Cys Ala Gly Ala Thr 
            20                  25                  30          


Gly Ala Ala Gly Ala Ala Gly Cys Cys Thr Gly Gly Cys Gly Ala Cys 
        35                  40                  45              


Thr Cys Gly Ala Thr Gly Ala Gly Ala Ala Thr Thr Thr Cys Thr Thr 
    50                  55                  60                  


Gly Thr Cys Gly Gly Gly Cys Thr Thr Cys Gly Gly Gly Ala Thr Ala 
65                  70                  75                  80  


Cys Gly Ala Ala Thr Thr Thr Ala Thr Thr Ala Ala Thr Thr Gly Thr 
                85                  90                  95      


Cys Cys Ala Ala Thr Ala Ala Ala Thr Thr Gly Gly Ala Thr Thr Cys 
            100                 105                 110         


Gly Gly Cys Thr Gly Gly Cys Cys Cys Cys Cys Gly Gly Ala Ala Ala 
        115                 120                 125             


Ala Ala Gly Gly Cys Cys Thr Gly Ala Gly Thr Gly Gly Ala Thr Gly 
    130                 135                 140                 


Gly Gly Ala Thr Gly Gly Ala Thr Gly Ala Ala Gly Cys Cys Thr Ala 
145                 150                 155                 160 


Gly Gly Cys Ala Thr Gly Gly Gly Gly Cys Cys Gly Thr Cys Ala Gly 
                165                 170                 175     


Thr Thr Ala Cys Gly Cys Ala Cys Gly Thr Cys Ala Ala Cys Thr Thr 
            180                 185                 190         


Cys Ala Gly Gly Gly Cys Ala Gly Ala Gly Thr Gly Ala Cys Cys Ala 
        195                 200                 205             


Thr Gly Ala Cys Thr Cys Gly Ala Cys Ala Ala Thr Thr Ala Thr Cys 
    210                 215                 220                 


Thr Cys Ala Ala Gly Ala Cys Cys Cys Ala Gly Ala Cys Gly Ala Cys 
225                 230                 235                 240 


Cys Cys Gly Gly Ala Cys Thr Gly Gly Gly Gly Cys Ala Cys Ala Gly 
                245                 250                 255     


Cys Cys Thr Thr Thr Thr Thr Gly Gly Ala Gly Cys Thr Cys Cys Gly 
            260                 265                 270         


Thr Thr Cys Cys Thr Thr Gly Ala Cys Ala Thr Cys Cys Gly Ala Cys 
        275                 280                 285             


Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr 
    290                 295                 300                 


Thr Thr Thr Gly Thr Ala Cys Thr Cys Gly Gly Gly Gly Ala Ala Ala 
305                 310                 315                 320 


Ala Thr Ala Thr Thr Gly Cys Ala Cys Thr Gly Cys Gly Cys Gly Cys 
                325                 330                 335     


Gly Ala Cys Thr Ala Thr Thr Ala Thr Ala Ala Thr Thr Gly Gly Gly 
            340                 345                 350         


Ala Cys Thr Thr Cys Gly Ala Ala Cys Ala Cys Thr Gly Gly Gly Gly 
        355                 360                 365             


Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Cys Gly Gly Thr Cys 
    370                 375                 380                 


Ala Cys Cys Gly Thr Cys Thr Cys Gly Thr Cys Ala 
385                 390                 395     


<210>  45
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  45

Ala Thr Gly Gly Gly Ala Thr Gly Gly Thr Cys Ala Thr Gly Thr Ala 
1               5                   10                  15      


Thr Cys Ala Thr Cys Cys Thr Thr Thr Thr Thr Cys Thr Ala Gly Thr 
            20                  25                  30          


Ala Gly Cys Ala Ala Cys Thr Gly Cys Ala Ala Cys Cys Gly Gly Thr 
        35                  40                  45              


Gly Thr Ala Cys Ala Thr Thr Cys Ala Thr Cys Thr Thr Thr Gly Ala 
    50                  55                  60                  


Cys Ala Cys Ala Gly Thr Cys Thr Cys Cys Ala Gly Gly Cys Ala Cys 
65                  70                  75                  80  


Cys Cys Thr Gly Thr Cys Thr Thr Thr Gly Thr Cys Thr Cys Cys Ala 
                85                  90                  95      


Gly Gly Gly Gly Ala Ala Ala Cys Ala Gly Cys Cys Ala Thr Cys Ala 
            100                 105                 110         


Thr Cys Thr Cys Thr Thr Gly Thr Cys Gly Gly Ala Cys Cys Ala Gly 
        115                 120                 125             


Thr Cys Ala Gly Thr Ala Thr Gly Gly Thr Thr Cys Cys Thr Thr Ala 
    130                 135                 140                 


Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys Ala Gly Ala 
145                 150                 155                 160 


Gly Gly Cys Cys Cys Gly Gly Cys Cys Ala Gly Gly Cys Cys Cys Cys 
                165                 170                 175     


Cys Ala Gly Gly Cys Thr Cys Gly Thr Cys Ala Thr Cys Thr Ala Thr 
            180                 185                 190         


Thr Cys Gly Gly Gly Cys Thr Cys Thr Ala Cys Thr Cys Gly Gly Gly 
        195                 200                 205             


Cys Cys Gly Cys Thr Gly Gly Cys Ala Thr Cys Cys Cys Ala Gly Ala 
    210                 215                 220                 


Cys Ala Gly Gly Thr Thr Cys Ala Gly Cys Gly Gly Cys Ala Gly Thr 
225                 230                 235                 240 


Cys Gly Gly Thr Gly Gly Gly Gly Gly Cys Cys Ala Gly Ala Cys Thr 
                245                 250                 255     


Ala Cys Ala Ala Thr Cys Thr Cys Ala Cys Cys Ala Thr Cys Ala Gly 
            260                 265                 270         


Cys Ala Ala Cys Cys Thr Gly Gly Ala Gly Thr Cys Gly Gly Gly Ala 
        275                 280                 285             


Gly Ala Thr Thr Thr Thr Gly Gly Thr Gly Thr Thr Thr Ala Thr Thr 
    290                 295                 300                 


Ala Thr Thr Gly Cys Cys Ala Gly Cys Ala Gly Thr Ala Thr Gly Ala 
305                 310                 315                 320 


Ala Thr Thr Thr Thr Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Gly 
                325                 330                 335     


Ala Cys Cys Ala Ala Gly Gly Thr Cys Cys Ala Gly Gly Thr Cys Gly 
            340                 345                 350         


Ala Cys Ala Thr Thr Ala Ala Ala 
        355                 360 


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  46

Glu Asp Asp Asp Tyr 
1               5   


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  47

Gly Glu Asp Asp Asp Tyr 
1               5       


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  48

Gly Ser Gly Glu Asp Asp Asp Tyr 
1               5               


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  49

Glu Asp Asp Asp Tyr Gly 
1               5       


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  50

Gly Glu Asp Asp Asp Tyr Gly 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  51

Gly Ser Gly Glu Asp Asp Asp Tyr Gly 
1               5                   


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  52

Gly Gln Leu Ser Gln Asp Pro Asp Asp Pro Asp Trp Gly 
1               5                   10              


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  53

Gly Ser Gly Gln Leu Ser Gln Asp Pro Asp Asp Pro Asp Trp Gly 
1               5                   10                  15  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  54

Gly Gln Leu Ser Gln Asp Pro Asp Asp Pro Asp Trp Gly Ser 
1               5                   10                  


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  55

Gln Leu Ser Gln Asp Pro Asp Asp Pro Asp Trp Gly Asp 
1               5                   10              


<210>  56
<211>  125
<212>  PRT
<213>  homo sapiens

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ser Gly Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Trp Thr Ser Glu Asp Ile Phe Glu Arg Thr 
            20                  25                  30          


Glu Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Val Lys Thr Val Thr Gly Ala Val Asn Phe Gly Ser Pro 
    50                  55                  60                  


Asp Phe Arg Gln Arg Val Ser Leu Thr Arg Asp Arg Asp Leu Phe Thr 
65                  70                  75                  80  


Ala His Met Asp Ile Arg Gly Leu Thr Gln Gly Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Gln Lys Phe Tyr Thr Gly Gly Gln Gly Trp Tyr Phe 
            100                 105                 110         


Asp Leu Trp Gly Arg Gly Thr Leu Ile Val Val Ser Ser 
        115                 120                 125 


<210>  57
<211>  104
<212>  PRT
<213>  homo sapiens

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Leu Ser Cys Thr Ala Ala Ser Tyr Gly His Met Thr 
            20                  25                  30          


Trp Tyr Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Ala 
        35                  40                  45              


Thr Ser Lys Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gln 
    50                  55                  60                  


Phe Gly Lys Gln Tyr Thr Leu Thr Ile Thr Arg Met Glu Pro Glu Asp 
65                  70                  75                  80  


Phe Ala Arg Tyr Tyr Cys Gln Gln Leu Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Arg Leu Glu Ile Arg Arg Thr Val 
            100                 


<210>  58
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ser Gly Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Trp Thr Ser Glu Asp Ile Phe Glu Arg Thr 
            20                  25                  30          


Glu Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Val Lys Thr Val Thr Gly Ala Val Asn Phe Gly Ser Pro 
    50                  55                  60                  


Asp Phe Arg Gln Arg Val Ser Leu Thr Arg Gln Leu Ser Gln Asp Pro 
65                  70                  75                  80  


Asp Asp Pro Asp Trp Gly Thr Ala His Met Asp Ile Arg Gly Leu Thr 
                85                  90                  95      


Gln Gly Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gln Lys Phe Tyr Thr 
            100                 105                 110         


Gly Gly Gln Gly Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Ile 
        115                 120                 125             


Val Val Ser Ser 
    130         


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  59

Thr Glu Leu Ile His 
1               5   


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  60

Trp Val Lys Thr Val Thr Gly Ala Val Asn Phe Gly Ser Pro Asp Phe 
1               5                   10                  15      


Arg Gln 
        


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  61

Gln Lys Phe Tyr Thr Gly Gly Gln Gly Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  62

Thr Ala Ala Ser Tyr Gly His Met Thr 
1               5                   


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  63

Ala Thr Ser Lys Arg Ala Ser 
1               5           


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  64

Gln Gln Leu Glu Phe 
1               5   


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  65

Trp Leu Lys Pro Arg Trp Gly Ala Val Asn Tyr Ala Arg Pro Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  66

Asp Tyr Phe Ile His 
1               5   


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  67

Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  68

Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
1               5                   10  


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  69

Gln Ala Asn Gly Tyr Leu Asn 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  70

Asp Gly Ser Lys Leu Glu Arg 
1               5           


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  71

Gln Val Tyr Glu Phe 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  72

Asp Tyr Ile Ile His 
1               5   


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  73

Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  74

Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp Phe 
1               5                   10                  15      


Leu Asp Leu 
            


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  75

Thr Gly Thr His Asn Leu Val Ser 
1               5               


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  76

Asp Phe Asn Lys Arg Pro Ser 
1               5           


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  77

Trp Ala Tyr Glu Ala 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  78

Glu Ile Leu Ile Asn 
1               5   


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  79

Trp Met Asn Pro Arg Gly Gly Gly Val Asn Tyr Ala Arg Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  80

Gly Arg Ser Cys Cys Gly Gly Arg Arg His Cys Asn Gly Ala Asp Cys 
1               5                   10                  15      


Phe Asn 
        


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  81

Lys Thr Ser Gln Ala Ile Thr Pro Arg His Leu Val 
1               5                   10          


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  82

Gly Thr Ser Glu Arg Ala Ser 
1               5           


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  83

Gln Cys Leu Glu Ala 
1               5   


<210>  84
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Trp Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn 
            100                 105                 110         


Trp Asp Phe Glu His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120                 125             


<210>  85
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  85

Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala 
1               5                   10                  15      


Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr 
        35                  40                  45              


Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro 
    50                  55                  60                  


Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln 
                85                  90                  95      


Val Asp Ile Lys 
            100 


<210>  86
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  86

Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
            100                 105                 110         


Phe Asp Val Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  87
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  87

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp Pro 
65                  70                  75                  80  


Asp Trp Gly Thr Ala Phe Leu Asp Leu Arg Gly Leu Lys Ser Asp Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Val Arg Asp Arg Ser Asn Gly Ser Gly Lys 
            100                 105                 110         


Arg Phe Glu Ser Ser Asn Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr 
        115                 120                 125             


Ala Val Thr Ile Gln Ser 
    130                 


<210>  88
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  88

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys 
            100             


<210>  89
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  89

Glu Val Gln Leu Val Gln Ser Gly Thr Gln Met Lys Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Val Thr Ser Gly Tyr Glu Phe Val Glu Ile 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Val Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Arg Gly Gly Gly Val Asn Tyr Ala Arg Gln Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Tyr Leu Thr Leu Ser Gly Leu Thr Ser Gly 
                85                  90                  95      


Asp Thr Ala Lys Tyr Phe Cys Val Arg Gly Arg Ser Cys Cys Gly Gly 
            100                 105                 110         


Arg Arg His Cys Asn Gly Ala Asp Cys Phe Asn Trp Asp Phe Gln His 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Ile Val Ser Pro 
    130                 135                 


<210>  90
<211>  104
<212>  PRT
<213>  homo sapiens

<400>  90

Tyr Ile Gly Val Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Thr Ser Gln Ala Ile Thr Pro Arg 
            20                  25                  30          


His Leu Val Trp His Arg Gln Lys Gly Gly Gln Ala Pro Ser Leu Val 
        35                  40                  45              


Met Thr Gly Thr Ser Glu Arg Ala Ser Gly Ile Pro Asp Arg Phe Ile 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Cys Leu Glu Ala Phe Gly 
                85                  90                  95      


Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 


<210>  91
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Trp Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn 
            100                 105                 110         


Trp Asp Phe Glu His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120                 125             


Pro Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        355                 360                 365             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  92
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  92

Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala 
1               5                   10                  15      


Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr 
        35                  40                  45              


Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro 
    50                  55                  60                  


Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln 
                85                  90                  95      


Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
            100                 105                 110         


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
        115                 120                 125             


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
    130                 135                 140                 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
145                 150                 155                 160 


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
                165                 170                 175     


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
            180                 185                 190         


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        195                 200                 205         


<210>  93
<211>  1431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  93

Ala Thr Gly Gly Gly Ala Thr Gly Gly Thr Cys Ala Thr Gly Thr Ala 
1               5                   10                  15      


Thr Cys Ala Thr Cys Cys Thr Thr Thr Thr Thr Cys Thr Ala Gly Thr 
            20                  25                  30          


Ala Gly Cys Ala Ala Cys Thr Gly Cys Ala Ala Cys Cys Gly Gly Thr 
        35                  40                  45              


Gly Thr Ala Cys Ala Thr Thr Cys Cys Cys Ala Gly Gly Thr Gly Cys 
    50                  55                  60                  


Ala Gly Cys Thr Gly Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Thr Cys Ala Gly Ala Thr Gly Ala Ala Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Cys Gly Ala Gly Thr Cys Gly Ala Thr Gly Ala 
            100                 105                 110         


Gly Ala Ala Thr Thr Thr Cys Thr Thr Gly Thr Cys Gly Gly Gly Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Ala Thr Ala Thr Gly Ala Ala Thr Thr Thr 
    130                 135                 140                 


Ala Thr Thr Gly Ala Thr Thr Gly Thr Ala Cys Gly Cys Thr Ala Ala 
145                 150                 155                 160 


Ala Thr Thr Gly Gly Ala Thr Thr Cys Gly Thr Cys Thr Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Cys Gly Gly Ala Ala Ala Ala Ala Gly Gly Cys Cys Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala Thr Gly Gly Cys 
        195                 200                 205             


Thr Gly Ala Ala Gly Cys Cys Thr Cys Gly Gly Thr Gly Gly Gly Gly 
    210                 215                 220                 


Gly Gly Cys Cys Gly Thr Cys Ala Ala Cys Thr Ala Cys Gly Cys Ala 
225                 230                 235                 240 


Cys Gly Thr Cys Cys Ala Cys Thr Thr Cys Ala Gly Gly Gly Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr Gly Ala Cys Thr Cys Gly 
            260                 265                 270         


Ala Cys Ala Gly Cys Thr Gly Ala Gly Cys Cys Ala Gly Gly Ala Cys 
        275                 280                 285             


Cys Cys Thr Gly Ala Cys Gly Ala Thr Cys Cys Cys Gly Ala Thr Thr 
    290                 295                 300                 


Gly Gly Gly Gly Cys Ala Cys Ala Gly Cys Cys Thr Thr Thr Thr Thr 
305                 310                 315                 320 


Gly Gly Ala Gly Cys Thr Gly Cys Gly Cys Thr Cys Gly Thr Thr Gly 
                325                 330                 335     


Ala Cys Ala Gly Thr Ala Gly Ala Cys Gly Ala Cys Ala Cys Gly Gly 
            340                 345                 350         


Cys Cys Gly Thr Cys Thr Ala Cys Thr Thr Thr Thr Gly Thr Ala Cys 
        355                 360                 365             


Thr Ala Gly Gly Gly Gly Ala Ala Ala Ala Ala Ala Cys Thr Gly Thr 
    370                 375                 380                 


Gly Ala Thr Thr Ala Cys Ala Ala Thr Thr Gly Gly Gly Ala Cys Thr 
385                 390                 395                 400 


Thr Cys Gly Ala Ala Cys Ala Cys Thr Gly Gly Gly Gly Cys Cys Gly 
                405                 410                 415     


Gly Gly Gly Cys Ala Cys Cys Cys Cys Gly Gly Thr Cys Ala Thr Cys 
            420                 425                 430         


Gly Thr Cys Thr Cys Ala Thr Cys Ala Cys Cys Gly Thr Cys Gly Ala 
        435                 440                 445             


Cys Cys Ala Ala Gly Gly Gly Cys Cys Cys Ala Thr Cys Gly Gly Thr 
    450                 455                 460                 


Cys Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly Cys Ala Cys Cys Cys 
465                 470                 475                 480 


Thr Cys Cys Thr Cys Cys Ala Ala Gly Ala Gly Cys Ala Cys Cys Thr 
                485                 490                 495     


Cys Thr Gly Gly Gly Gly Gly Cys Ala Cys Ala Gly Cys Gly Gly Cys 
            500                 505                 510         


Cys Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys Thr Gly Gly Thr Cys 
        515                 520                 525             


Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr Cys Cys Cys Cys Gly 
    530                 535                 540                 


Ala Ala Cys Cys Gly Gly Thr Gly Ala Cys Gly Gly Thr Gly Thr Cys 
545                 550                 555                 560 


Gly Thr Gly Gly Ala Ala Cys Thr Cys Ala Gly Gly Cys Gly Cys Cys 
                565                 570                 575     


Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly Thr Gly Cys 
            580                 585                 590         


Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Gly Gly Cys Thr Gly Thr 
        595                 600                 605             


Cys Cys Thr Ala Cys Ala Gly Thr Cys Cys Thr Cys Ala Gly Gly Ala 
    610                 615                 620                 


Cys Thr Cys Thr Ala Cys Thr Cys Cys Cys Thr Cys Ala Gly Cys Ala 
625                 630                 635                 640 


Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr Gly Cys Cys 
                645                 650                 655     


Cys Thr Cys Cys Ala Gly Cys Ala Gly Cys Thr Thr Gly Gly Gly Cys 
            660                 665                 670         


Ala Cys Cys Cys Ala Gly Ala Cys Cys Thr Ala Cys Ala Thr Cys Thr 
        675                 680                 685             


Gly Cys Ala Ala Cys Gly Thr Gly Ala Ala Thr Cys Ala Cys Ala Ala 
    690                 695                 700                 


Gly Cys Cys Cys Ala Gly Cys Ala Ala Cys Ala Cys Cys Ala Ala Gly 
705                 710                 715                 720 


Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Ala Ala Gly Thr Thr Gly 
                725                 730                 735     


Ala Gly Cys Cys Cys Ala Ala Ala Thr Cys Thr Thr Gly Thr Gly Ala 
            740                 745                 750         


Cys Ala Ala Ala Ala Cys Thr Cys Ala Cys Ala Cys Ala Thr Gly Cys 
        755                 760                 765             


Cys Cys Ala Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala Cys 
    770                 775                 780                 


Cys Thr Gly Ala Ala Cys Thr Cys Cys Thr Gly Gly Gly Gly Gly Gly 
785                 790                 795                 800 


Ala Cys Cys Gly Thr Cys Ala Gly Thr Cys Thr Thr Cys Cys Thr Cys 
                805                 810                 815     


Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala Ala Ala Cys Cys Cys Ala 
            820                 825                 830         


Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Cys Ala Thr Gly Ala Thr 
        835                 840                 845             


Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys Cys Cys Thr Gly Ala Gly 
    850                 855                 860                 


Gly Thr Cys Ala Cys Ala Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly 
865                 870                 875                 880 


Thr Gly Gly Ala Cys Gly Thr Gly Ala Gly Cys Cys Ala Cys Gly Ala 
                885                 890                 895     


Ala Gly Ala Cys Cys Cys Thr Gly Ala Gly Gly Thr Cys Ala Ala Gly 
            900                 905                 910         


Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly 
        915                 920                 925             


Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala 
    930                 935                 940                 


Thr Ala Ala Thr Gly Cys Cys Ala Ala Gly Ala Cys Ala Ala Ala Gly 
945                 950                 955                 960 


Cys Cys Gly Cys Gly Gly Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr 
                965                 970                 975     


Ala Cys Ala Ala Cys Ala Gly Cys Ala Cys Gly Thr Ala Cys Cys Gly 
            980                 985                 990         


Thr Gly Thr Gly Gly Thr Cys Ala  Gly Cys Gly Thr Cys  Cys Thr Cys 
        995                 1000                 1005             


Ala Cys  Cys Gly Thr Cys Cys  Thr Gly Cys Ala Cys  Cys Ala Gly 
    1010                 1015                 1020             


Gly Ala  Cys Thr Gly Gly Cys  Thr Gly Ala Ala Thr  Gly Gly Cys 
    1025                 1030                 1035             


Ala Ala  Gly Gly Ala Gly Thr  Ala Cys Ala Ala Gly  Thr Gly Cys 
    1040                 1045                 1050             


Ala Ala  Gly Gly Thr Cys Thr  Cys Cys Ala Ala Cys  Ala Ala Ala 
    1055                 1060                 1065             


Gly Cys  Cys Cys Thr Cys Cys  Cys Ala Gly Cys Cys  Cys Cys Cys 
    1070                 1075                 1080             


Ala Thr  Cys Gly Ala Gly Ala  Ala Ala Ala Cys Cys  Ala Thr Cys 
    1085                 1090                 1095             


Thr Cys  Cys Ala Ala Ala Gly  Cys Cys Ala Ala Ala  Gly Gly Gly 
    1100                 1105                 1110             


Cys Ala  Gly Cys Cys Cys Cys  Gly Ala Gly Ala Ala  Cys Cys Ala 
    1115                 1120                 1125             


Cys Ala  Gly Gly Thr Gly Thr  Ala Cys Ala Cys Cys  Cys Thr Gly 
    1130                 1135                 1140             


Cys Cys  Cys Cys Cys Ala Thr  Cys Cys Cys Gly Gly  Gly Ala Thr 
    1145                 1150                 1155             


Gly Ala  Gly Cys Thr Gly Ala  Cys Cys Ala Ala Gly  Ala Ala Cys 
    1160                 1165                 1170             


Cys Ala  Gly Gly Thr Cys Ala  Gly Cys Cys Thr Gly  Ala Cys Cys 
    1175                 1180                 1185             


Thr Gly  Cys Cys Thr Gly Gly  Thr Cys Ala Ala Ala  Gly Gly Cys 
    1190                 1195                 1200             


Thr Thr  Cys Thr Ala Thr Cys  Cys Cys Ala Gly Cys  Gly Ala Cys 
    1205                 1210                 1215             


Ala Thr  Cys Gly Cys Cys Gly  Thr Gly Gly Ala Gly  Thr Gly Gly 
    1220                 1225                 1230             


Gly Ala  Gly Ala Gly Cys Ala  Ala Thr Gly Gly Gly  Cys Ala Gly 
    1235                 1240                 1245             


Cys Cys  Gly Gly Ala Gly Ala  Ala Cys Ala Ala Cys  Thr Ala Cys 
    1250                 1255                 1260             


Ala Ala  Gly Ala Cys Cys Ala  Cys Gly Cys Cys Thr  Cys Cys Cys 
    1265                 1270                 1275             


Gly Thr  Gly Cys Thr Gly Gly  Ala Cys Thr Cys Cys  Gly Ala Cys 
    1280                 1285                 1290             


Gly Gly  Cys Thr Cys Cys Thr  Thr Cys Thr Thr Cys  Cys Thr Cys 
    1295                 1300                 1305             


Thr Ala  Cys Ala Gly Cys Ala  Ala Gly Cys Thr Cys  Ala Cys Cys 
    1310                 1315                 1320             


Gly Thr  Gly Gly Ala Cys Ala  Ala Gly Ala Gly Cys  Ala Gly Gly 
    1325                 1330                 1335             


Thr Gly  Gly Cys Ala Gly Cys  Ala Gly Gly Gly Gly  Ala Ala Cys 
    1340                 1345                 1350             


Gly Thr  Cys Thr Thr Cys Thr  Cys Ala Thr Gly Cys  Thr Cys Cys 
    1355                 1360                 1365             


Gly Thr  Gly Cys Thr Gly Cys  Ala Thr Gly Ala Gly  Gly Cys Thr 
    1370                 1375                 1380             


Cys Thr  Gly Cys Ala Cys Ala  Gly Cys Cys Ala Cys  Thr Ala Cys 
    1385                 1390                 1395             


Ala Cys  Gly Cys Ala Gly Ala  Ala Gly Ala Gly Cys  Cys Thr Cys 
    1400                 1405                 1410             


Thr Cys  Cys Cys Thr Gly Thr  Cys Thr Cys Cys Gly  Gly Gly Thr 
    1415                 1420                 1425             


Ala Ala  Ala 
    1430     


<210>  94
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  94

Ala Thr Gly Gly Gly Ala Thr Gly Gly Thr Cys Ala Thr Gly Thr Ala 
1               5                   10                  15      


Thr Cys Ala Thr Cys Cys Thr Thr Thr Thr Thr Cys Thr Ala Gly Thr 
            20                  25                  30          


Ala Gly Cys Ala Ala Cys Thr Gly Cys Ala Ala Cys Cys Gly Gly Thr 
        35                  40                  45              


Gly Thr Ala Cys Ala Thr Thr Cys Ala Thr Thr Gly Ala Cys Ala Cys 
    50                  55                  60                  


Ala Gly Thr Cys Thr Cys Cys Ala Gly Gly Cys Ala Cys Cys Cys Thr 
65                  70                  75                  80  


Gly Thr Cys Thr Thr Thr Gly Thr Cys Thr Cys Cys Ala Gly Gly Gly 
                85                  90                  95      


Gly Ala Ala Ala Cys Ala Gly Cys Cys Ala Thr Cys Ala Thr Cys Thr 
            100                 105                 110         


Cys Thr Thr Gly Thr Cys Gly Gly Ala Cys Cys Ala Gly Thr Cys Ala 
        115                 120                 125             


Gly Thr Ala Thr Gly Gly Thr Thr Cys Cys Thr Thr Ala Gly Cys Cys 
    130                 135                 140                 


Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys Ala Gly Ala Gly Gly Cys 
145                 150                 155                 160 


Cys Cys Gly Gly Cys Cys Ala Gly Gly Cys Cys Cys Cys Cys Ala Gly 
                165                 170                 175     


Gly Cys Thr Cys Gly Thr Cys Ala Thr Cys Thr Ala Thr Thr Cys Gly 
            180                 185                 190         


Gly Gly Cys Thr Cys Thr Ala Cys Thr Cys Gly Gly Gly Cys Cys Gly 
        195                 200                 205             


Cys Thr Gly Gly Cys Ala Thr Cys Cys Cys Ala Gly Ala Cys Ala Gly 
    210                 215                 220                 


Gly Thr Thr Cys Ala Gly Cys Gly Gly Cys Ala Gly Thr Cys Gly Gly 
225                 230                 235                 240 


Thr Gly Gly Gly Gly Gly Cys Cys Ala Gly Ala Cys Thr Ala Cys Ala 
                245                 250                 255     


Ala Thr Cys Thr Cys Ala Cys Cys Ala Thr Cys Ala Gly Cys Ala Ala 
            260                 265                 270         


Cys Cys Thr Gly Gly Ala Gly Thr Cys Gly Gly Gly Ala Gly Ala Thr 
        275                 280                 285             


Thr Thr Thr Gly Gly Thr Gly Thr Thr Thr Ala Thr Thr Ala Thr Thr 
    290                 295                 300                 


Gly Cys Cys Ala Gly Cys Ala Gly Thr Ala Thr Gly Ala Ala Thr Thr 
305                 310                 315                 320 


Thr Thr Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Gly Ala Cys Cys 
                325                 330                 335     


Ala Ala Gly Gly Thr Cys Cys Ala Gly Gly Thr Cys Gly Ala Cys Ala 
            340                 345                 350         


Thr Thr Ala Ala Ala Cys Gly Thr Ala Cys Gly Gly Thr Gly Gly Cys 
        355                 360                 365             


Thr Gly Cys Ala Cys Cys Ala Thr Cys Thr Gly Thr Cys Thr Thr Cys 
    370                 375                 380                 


Ala Thr Cys Thr Thr Cys Cys Cys Gly Cys Cys Ala Thr Cys Thr Gly 
385                 390                 395                 400 


Ala Thr Gly Ala Gly Cys Ala Gly Thr Thr Gly Ala Ala Ala Thr Cys 
                405                 410                 415     


Thr Gly Gly Ala Ala Cys Thr Gly Cys Cys Thr Cys Thr Gly Thr Thr 
            420                 425                 430         


Gly Thr Gly Thr Gly Cys Cys Thr Gly Cys Thr Gly Ala Ala Thr Ala 
        435                 440                 445             


Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Cys Ala Gly Ala Gly Ala 
    450                 455                 460                 


Ala Gly Cys Cys Ala Ala Ala Gly Thr Gly Cys Ala Gly Thr Gly Gly 
465                 470                 475                 480 


Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Cys Gly Cys Cys Cys 
                485                 490                 495     


Thr Gly Cys Ala Gly Ala Gly Cys Gly Gly Ala Ala Ala Cys Ala Gly 
            500                 505                 510         


Cys Cys Ala Gly Gly Ala Ala Ala Gly Cys Gly Thr Gly Ala Cys Ala 
        515                 520                 525             


Gly Ala Gly Cys Ala Gly Gly Ala Thr Thr Cys Cys Ala Ala Gly Gly 
    530                 535                 540                 


Ala Thr Thr Cys Cys Ala Cys Ala Thr Ala Cys Ala Gly Cys Cys Thr 
545                 550                 555                 560 


Gly Ala Gly Cys Ala Gly Cys Ala Cys Ala Cys Thr Gly Ala Cys Ala 
                565                 570                 575     


Cys Thr Gly Thr Cys Cys Ala Ala Gly Gly Cys Cys Gly Ala Cys Thr 
            580                 585                 590         


Ala Cys Gly Ala Gly Ala Ala Gly Cys Ala Cys Ala Ala Gly Gly Thr 
        595                 600                 605             


Gly Thr Ala Cys Gly Cys Cys Thr Gly Cys Gly Ala Ala Gly Thr Gly 
    610                 615                 620                 


Ala Cys Ala Cys Ala Cys Cys Ala Gly Gly Gly Ala Cys Thr Gly Thr 
625                 630                 635                 640 


Cys Cys Thr Cys Cys Cys Cys Thr Gly Thr Gly Ala Cys Ala Ala Ala 
                645                 650                 655     


Gly Ala Gly Cys Thr Thr Cys Ala Ala Cys Ala Gly Ala Gly Gly Ala 
            660                 665                 670         


Gly Ala Ala Thr Gly Cys 
        675             


<210>  95
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  95

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Trp Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Ile Ala Tyr Met Asp Ile Arg Gly Leu Lys Pro Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Ser Tyr Gly Asp Ser 
            100                 105                 110         


Ser Trp Ala Leu Asp Ala Trp Gly Gln Gly Thr Thr Val Val Val Ser 
        115                 120                 125             


Ala 
    


<210>  96
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  96

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Ile Ala Tyr Met Asp Ile Arg Gly Leu Lys Pro Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Ser Ser Gly Asp Ser 
            100                 105                 110         


Ser Trp Ala Leu Asp Ala Trp Gly Gln Gly Thr Thr Val Val Val Ser 
        115                 120                 125             


Ala 
    


<210>  97
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  97

His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp Leu His 
            20                  25                  30          


Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile His His 
        35                  40                  45              


Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala Asp Asp 
65                  70                  75                  80  


Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg Gly Ser 
                85                  90                  95      


Arg Leu His Ile Lys 
            100     


<210>  98
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  98

Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly Asp Arg Val 
1               5                   10                  15      


Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp Leu His Trp 
            20                  25                  30          


Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile His His Thr 
        35                  40                  45              


Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Phe 
    50                  55                  60                  


His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala Asp Asp Ile 
65                  70                  75                  80  


Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg Gly Ser Arg 
                85                  90                  95      


Leu His Ile Lys 
            100 


<210>  99
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  99

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Ile Ala Tyr Met Asp Ile Arg Gly Leu Lys Pro Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Ser Tyr Gly Asp Ser 
            100                 105                 110         


Ser Trp Ala Leu Asp Ala Trp Gly Gln Gly Thr Thr Val Val Val Ser 
        115                 120                 125             


Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Leu His Ala Leu His Ser His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  100
<211>  210
<212>  PRT
<213>  homo sapiens

<400>  100

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
145                 150                 155                 160 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
                165                 170                 175     


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
            180                 185                 190         


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
        195                 200                 205             


Glu Cys 
    210 


<210>  101
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  101

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg Trp Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Thr Arg Gly Lys Tyr Cys Thr Ala Arg 
            100                 105                 110         


Asp Tyr Tyr Asn Trp Asp Phe Glu His Trp Gly Gln Gly Thr Pro Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  102
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  102

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg Phe Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Thr Arg Gly Lys Tyr Cys Thr Ala Arg 
            100                 105                 110         


Asp Tyr Tyr Asn Trp Asp Phe Glu His Trp Gly Gln Gly Thr Pro Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  103
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  103

Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala 
1               5                   10                  15      


Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr 
        35                  40                  45              


Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro 
    50                  55                  60                  


Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln 
                85                  90                  95      


Val Asp Ile Lys 
            100 


<210>  104
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  104

Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala 
1               5                   10                  15      


Ile Ile Ser Cys Asp Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr 
        35                  40                  45              


Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro 
    50                  55                  60                  


Asp Tyr Gln Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln 
                85                  90                  95      


Val Asp Ile Lys 
            100 


<210>  105
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  105

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Trp Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp Pro 
65                  70                  75                  80  


Asp Trp Gly Thr Ala Phe Leu Asp Leu Arg Gly Leu Lys Ser Asp Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Val Arg Asp Arg Ser Asn Gly Ser Gly Lys 
            100                 105                 110         


Arg Phe Glu Ser Ser Asn Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr 
        115                 120                 125             


Ala Val Thr Ile Gln Ser 
    130                 


<210>  106
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  106

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln Ser Val 
1               5                   10                  15      


Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys Gln His 
            20                  25                  30          


Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Gly Thr 
    50                  55                  60                  


Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala Glu Tyr 
65                  70                  75                  80  


Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val 
                85                  90                  95      


Leu Gly Gln Pro Lys 
            100     


<210>  107
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  107

Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln Ser Val Thr 
1               5                   10                  15      


Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys Gln His Gln 
            20                  25                  30          


Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn Lys Arg Pro 
        35                  40                  45              


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Gly Thr Ala 
    50                  55                  60                  


Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala Glu Tyr Phe 
65                  70                  75                  80  


Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                85                  90                  95      


Gly Gln Pro Lys 
            100 


<210>  108
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  108

Glu Val Gln Leu Val Gln Ser Gly Thr Gln Met Lys Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Val Thr Ser Gly Tyr Glu Phe Val Glu Ile 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Val Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Arg Trp Gly Gly Val Asn Tyr Ala Arg Gln Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Tyr Leu Thr Leu Ser Gly Leu Thr Ser Gly 
                85                  90                  95      


Asp Thr Ala Lys Tyr Phe Cys Val Arg Gly Arg Ser Cys Cys Gly Gly 
            100                 105                 110         


Arg Arg His Cys Asn Gly Ala Asp Cys Phe Asn Trp Asp Phe Gln His 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Ile Val Ser Pro 
    130                 135                 


<210>  109
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  109

Gly Val Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Leu Gly Glu Arg 
1               5                   10                  15      


Val Thr Leu Ser Cys Lys Thr Ser Gln Ala Ile Thr Pro Arg His Leu 
            20                  25                  30          


Val Trp His Arg Gln Lys Gly Gly Gln Ala Pro Ser Leu Val Met Thr 
        35                  40                  45              


Gly Thr Ser Glu Arg Ala Ser Gly Ile Pro Asp Arg Phe Ile Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Cys Leu Glu Ala Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  110
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  110

Val Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Leu Gly Glu Arg Val 
1               5                   10                  15      


Thr Leu Ser Cys Lys Thr Ser Gln Ala Ile Thr Pro Arg His Leu Val 
            20                  25                  30          


Trp His Arg Gln Lys Gly Gly Gln Ala Pro Ser Leu Val Met Thr Gly 
        35                  40                  45              


Thr Ser Glu Arg Ala Ser Gly Ile Pro Asp Arg Phe Ile Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Ala Glu Asp 
65                  70                  75                  80  


Phe Ala Val Tyr Tyr Cys Gln Cys Leu Glu Ala Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Leu Glu Ile Lys 
            100     


<210>  111
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  111

Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Trp Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Tyr Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  112
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  112

Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Trp Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
            100                 105                 110         


Phe Asp Val Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  113
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  113

Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Thr 
1               5                   10                  15      


Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr Gln Gln 
            20                  25                  30          


Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser Lys Leu 
        35                  40                  45              


Glu Arg Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp Gly Gln Glu 
    50                  55                  60                  


Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
65                  70                  75                  80  


Phe Cys Gln Val Tyr Glu Phe Val Val Pro Gly Thr Arg Leu Asp Leu 
                85                  90                  95      


Lys 
    


<210>  114
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  114

Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val 
1               5                   10                  15      


Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr Gln Gln Arg 
            20                  25                  30          


Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser Lys Leu Glu 
        35                  40                  45              


Arg Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp Gly Gln Glu Tyr 
    50                  55                  60                  


Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe 
65                  70                  75                  80  


Cys Gln Val Tyr Glu Phe Val Val Pro Gly Thr Arg Leu Asp Leu Lys 
                85                  90                  95      


<210>  115
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  115

Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Phe Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
            100                 105                 110         


Phe Asp Val Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  116
<211>  127
<212>  PRT
<213>  homo sapiens

<400>  116

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser 
        115                 120                 125         


<210>  117
<211>  132
<212>  PRT
<213>  homo sapiens

<400>  117

Glu Val Gln Leu Val Gln Ser Gly Thr Gln Met Lys Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Val Thr Ser Gly Tyr Glu Phe Val Glu Ile 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Val Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Arg Gly Gly Gly Val Asn Tyr Ala Arg Gln Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Arg Asp Val Tyr Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Thr Leu Ser Gly Leu Thr Ser Gly Asp Thr Ala Lys Tyr Phe Cys 
                85                  90                  95      


Val Arg Gly Arg Ser Cys Cys Gly Gly Arg Arg His Cys Asn Gly Ala 
            100                 105                 110         


Asp Cys Phe Asn Trp Asp Phe Gln His Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Ile Val Ser Pro 
    130         


<210>  118
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  118

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Leu His Ala Leu His Ser His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 


<210>  119
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  119

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  120

Trp Met Asn Pro Met Trp Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  121

Trp Met Lys Pro Arg Phe Gly Ala Val Ser Tyr Ala Arg Gln Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  122

Trp Met Lys Pro Arg Trp Gly Ala Val Ser Tyr Ala Arg Gln Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant antibody sequence

<400>  123

Asp Thr Ser Gln Tyr Gly Ser Leu Ala 
1               5                   


