                         SEQUENCE LISTING

<110>  Technion Research & Development Foundation Limited
       REITER, Yoram
       HAIM, Netta
 
<120>  IMMUNOTHERAPEUTIC COMPOSITION FOR THE TREATMENT OF CANCER

<130>  76678

<150>  US 62/632,452
<151>  2018-02-20

<160>  197   

<170>  PatentIn version 3.5

<210>  1
<211>  139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Secretion Signal nucleic acid sequence

<400>  1
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtaa ggggttaaca       60

gtagcaggct tgaggtctgg acatatatat gggtgacaat gacatccact ttgcctttct      120

ctccacaggc gcgcacagt                                                   139


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretion Signal amino acid sequence

<400>  2

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  3
<211>  27
<212>  DNA
<213>  Influenza A virus

<400>  3
ctgtaccaga acgtgggcac ctacgtg                                           27


<210>  4
<211>  27
<212>  DNA
<213>  Influenza A virus

<400>  4
atctacagca ccgtggccag cagcctg                                           27


<210>  5
<211>  27
<212>  DNA
<213>  Influenza A virus

<400>  5
acctaccagc ggaccagagc cctcgtg                                           27


<210>  6
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  6
tacgccatga tctaccggaa cctg                                              24


<210>  7
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  7
aggacttata cctacgaaaa gctc                                              24


<210>  8
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  8
tcaggatacg acttcagtcg cctc                                              24


<210>  9
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  9

Leu Tyr Gln Asn Val Gly Thr Tyr Val 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  10

Ile Tyr Ser Thr Val Ala Ser Ser Leu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  11

Thr Tyr Gln Arg Thr Arg Ala Leu Val 
1               5                   


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Tyr Ala Met Ile Tyr Arg Asn Leu 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  13

Arg Thr Tyr Thr Tyr Glu Lys Leu 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  14

Ser Gly Tyr Asp Phe Ser Arg Leu 
1               5               


<210>  15
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker 15aa Long nucleic acid sequence

<400>  15
ggcggcggag gatctggcgg aggtggaagt gggggaggcg gcagc                       45


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 15aa Long amino acid sequence

<400>  16

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  17
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker 20aa long nucleic acid sequence

<400>  17
ggcggagggg gtagcggagg cggtggttct ggcggaggtg gctcaggggg agggggatct       60


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 20aa long amino acid sequence

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  19
<211>  297
<212>  DNA
<213>  Mus musculus

<400>  19
atccagaaaa ccccccagat ccaggtgtac agccggcacc cccccgagaa cggcaagccc       60

aacatcctga actgctacgt gacccagttc cacccccctc acatcgagat ccagatgctg      120

aagaatggca agaagatccc caaggtcgag atgagcgaca tgagcttcag caaggactgg      180

tccttctaca tcctggccca caccgagttc acccccaccg aaaccgacac ctacgcctgc      240

agagtgaagc acgtgtccat ggccgagccc aagaccgtgt actgggaccg ggatatg         297


<210>  20
<211>  99
<212>  PRT
<213>  Mus musculus

<400>  20

Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu 
1               5                   10                  15      


Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro 
            20                  25                  30          


Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys 
        35                  40                  45              


Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile 
    50                  55                  60                  


Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Lys His Val Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  21
<211>  840
<212>  DNA
<213>  Mus musculus

<400>  21
ggcccccaca gcctgcggta cttcgtgacc gccgtgtcca gacctggcct gggcgagccc       60

cggtacatgg aagtgggcta cgtggacgac accgagttcg tcagattcga cagcgacgcc      120

gagaacccca gatacgagcc cagagcccgg tggatggaac aggaaggccc cgagtactgg      180

gagagagaga cacagaaggc caagggcaac gagcagagct tccgggtgga cctgcggacc      240

ctgctgggct actacaacca gagcaagggc ggcagccaca ccatccaggt catcagcggc      300

tgcgaagtgg gaagcgacgg ccggctgctg cggggctacc agcagtacgc ctacgatggc      360

tgcgactata tcgccctgaa cgaggacctg aaaacctgga cagccgccga catggccgcc      420

ctgatcacca agcacaagtg ggagcaggcc ggggaggccg agagactgag agcctacctg      480

gaaggcacct gtgtggaatg gctgagaaga tacctgaaga acggcaacgc cacactgctg      540

agaaccgaca gccccaaggc ccacgtgacc caccacagca gacccgagga caaagtgacc      600

ctgcggtgct gggccctggg cttctacccc gccgatatca ccctgacctg gcagctgaac      660

ggcgaggaac tgatccagga catggaactg gtggaaaccc ggcctgccgg cgacggcacc      720

ttccagaaat gggccagcgt ggtggtgccc ctgggaaaag agcagtacta cacctgtcac      780

gtgtaccacc agggcctgcc cgagcccctg accctgagat gggagcctcc acctagcacc      840


<210>  22
<211>  280
<212>  PRT
<213>  Mus musculus

<400>  22

Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Leu Gly Glu Pro Arg Tyr Met Glu Val Gly Tyr Val Asp Asp Thr Glu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg Tyr Glu Pro Arg 
        35                  40                  45              


Ala Arg Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Arg Glu Thr 
    50                  55                  60                  


Gln Lys Ala Lys Gly Asn Glu Gln Ser Phe Arg Val Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Leu Gly Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Ile Gln 
                85                  90                  95      


Val Ile Ser Gly Cys Glu Val Gly Ser Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Tyr Ala Tyr Asp Gly Cys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Lys Thr Trp Thr Ala Ala Asp Met Ala Ala Leu Ile Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Gln Ala Gly Glu Ala Glu Arg Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly Asn 
                165                 170                 175     


Ala Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr His His 
            180                 185                 190         


Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu Leu 
    210                 215                 220                 


Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln Tyr 
                245                 250                 255     


Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Pro Pro Ser Thr 
        275                 280 


<210>  23
<211>  840
<212>  DNA
<213>  Mus musculus

<400>  23
ggcccccaca gcctgcggta cttcgtgacc gccgtgtcca gacctggcct gggcgagcct       60

agattcattg ccgtgggcta cgtggacgac acccagttcg tcagattcga cagcgacgcc      120

gacaaccccc gcttcgagcc cagagccccc tggatggaac aggaaggccc cgagtactgg      180

gaggaacaga cccagcgggc caagagcgac gagcagtggt tccgggtgtc cctgcggacc      240

gcccagcggt actacaacca gagcaagggc ggcagccaca ccttccagcg gatgttcggc      300

tgcgacgtgg gcagcgactg gcggctgctg agaggctacc agcagttcgc ctacgacggc      360

cgggactata tcgccctgaa cgaggacctg aaaacctgga cagccgccga cactgccgcc      420

ctgatcacca gacggaagtg ggaacaggcc ggcgacgctg agtactaccg ggcctacctg      480

gaaggcgagt gcgtggaatg gctgcggaga tatctggaac tgggcaacga gacactgctg      540

aggaccgaca gccccaaggc ccacgtgacc taccacccca gatcccaggt ggacgtgacc      600

ctgagatgct gggccctggg cttctacccc gccgatatca ccctgacctg gcagctgaac      660

ggcgaggatc tgacccagga catggaactc gtggaaaccc ggcctgccgg ggacggcacc      720

tttcagaaat gggccgctgt ggtggtgccc ctgggcaaag agcagaacta cacctgtcac      780

gtgcaccaca agggcctgcc cgagcctctg accctgcggt ggaagctgcc tcctagcacc      840


<210>  24
<211>  280
<212>  PRT
<213>  Mus musculus

<400>  24

Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Gln Thr 
    50                  55                  60                  


Gln Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu Arg Thr 
65                  70                  75                  80  


Ala Gln Arg Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Phe Gln 
                85                  90                  95      


Arg Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile Thr Arg 
    130                 135                 140                 


Arg Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu Gly Asn 
                165                 170                 175     


Glu Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr Tyr His 
            180                 185                 190         


Pro Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu 
    210                 215                 220                 


Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu Gln Asn 
                245                 250                 255     


Tyr Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Lys Leu Pro Pro Ser Thr 
        275                 280 


<210>  25
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Short Connector DNA sequence

<400>  25
gccagcggcg ga                                                           12


<210>  26
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti MCSP scFv of 225.28S DNA sequence

<400>  26
caggtcaaac tgcagcagag cggcggaggc ctggtgcagc ctggcggcag catgaagctg       60

agctgcgtgg tgtccggctt caccttcagc aactactgga tgaactgggt ccgacagagc      120

cccgagaagg gcctggaatg gatcgccgag atccggctga agtccaacaa cttcggccgg      180

tactacgccg agagcgtgaa gggcagattc accatcagcc gggacgacag caagagcagc      240

gcctacctgc agatgatcaa cctgcgggcc gaggacaccg gcatctacta ctgcaccagc      300

tacggcaact acgtgggcca ctacttcgac cactggggcc agggcaccac cgtgaccgtg      360

tctagcggag gcggaggatc tggcggaggt ggaagtggcg ggggaggcag cgatatcgag      420

ctgacccagt cccccaagtt catgagcacc agcgtgggcg accgggtgtc cgtgacatgc      480

aaggccagcc agaacgtgga caccaacgtg gcctggtatc agcagaagcc cggccagagc      540

cctgagcccc tgctgttcag cgccagctac agatacaccg gcgtgcccga caggttcacc      600

ggcagcggct ctggcaccga cttcaccctg accatctcca acgtgcagag cgaggacctg      660

gccgagtact tctgccagca gtacaacagc taccccctga cctttggagg cggcaccaag      720

ctggaaatca agcgggcc                                                    738


<210>  27
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti MCSP scFv of 225.28S amino acid sequence

<400>  27

Gln Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Ile Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Glu Pro Leu Leu Phe Ser Ala Ser Tyr Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg Ala 
                245     


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His Tag nucleic acid sequence

<400>  28
catcatcacc atcaccat                                                     18


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His Tag amino acid sequence

<400>  29

His His His His His His 
1               5       


<210>  30
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BirA Tag DNA sequence

<400>  30
ggacttaatg atatcttcga ggcgcagaag attgaatggc actga                       45


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BirA Tag amino acid sequence

<400>  31

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
1               5                   10                  


<210>  32
<211>  1480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CG DNA of Soluble single chain MHC: H2Kb molecule with YAMIYRNL 
       peptide with Tags, without the scFv nucleic acid sequence

<400>  32
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtaa ggggttaaca       60

gtagcaggct tgaggtctgg acatatatat gggtgacaat gacatccact ttgcctttct      120

ctccacaggc gcgcacagtt acgccatgat ctaccggaac ctgggcggcg gaggatctgg      180

cggaggtgga agtgggggag gcggcagcat ccagaaaacc ccccagatcc aggtgtacag      240

ccggcacccc cccgagaacg gcaagcccaa catcctgaac tgctacgtga cccagttcca      300

cccccctcac atcgagatcc agatgctgaa gaatggcaag aagatcccca aggtcgagat      360

gagcgacatg agcttcagca aggactggtc cttctacatc ctggcccaca ccgagttcac      420

ccccaccgaa accgacacct acgcctgcag agtgaagcac gtgtccatgg ccgagcccaa      480

gaccgtgtac tgggaccggg atatgggcgg agggggtagc ggaggcggtg gttctggcgg      540

aggtggctca gggggagggg gatctggccc ccacagcctg cggtacttcg tgaccgccgt      600

gtccagacct ggcctgggcg agccccggta catggaagtg ggctacgtgg acgacaccga      660

gttcgtcaga ttcgacagcg acgccgagaa ccccagatac gagcccagag cccggtggat      720

ggaacaggaa ggccccgagt actgggagag agagacacag aaggccaagg gcaacgagca      780

gagcttccgg gtggacctgc ggaccctgct gggctactac aaccagagca agggcggcag      840

ccacaccatc caggtcatca gcggctgcga agtgggaagc gacggccggc tgctgcgggg      900

ctaccagcag tacgcctacg atggctgcga ctatatcgcc ctgaacgagg acctgaaaac      960

ctggacagcc gccgacatgg ccgccctgat caccaagcac aagtgggagc aggccgggga     1020

ggccgagaga ctgagagcct acctggaagg cacctgtgtg gaatggctga gaagatacct     1080

gaagaacggc aacgccacac tgctgagaac cgacagcccc aaggcccacg tgacccacca     1140

cagcagaccc gaggacaaag tgaccctgcg gtgctgggcc ctgggcttct accccgccga     1200

tatcaccctg acctggcagc tgaacggcga ggaactgatc caggacatgg aactggtgga     1260

aacccggcct gccggcgacg gcaccttcca gaaatgggcc agcgtggtgg tgcccctggg     1320

aaaagagcag tactacacct gtcacgtgta ccaccagggc ctgcccgagc ccctgaccct     1380

gagatgggag cctccaccta gcaccgccag cggcggacat catcaccatc accatggact     1440

taatgatatc ttcgaggcgc agaagattga atggcactga                           1480


<210>  33
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CG Protein Soluble fusion molecule: H2Kb molecule with YAMIYRNL 
       peptide with Tags, without the scFv amino acid sequence

<400>  33

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Tyr Ala Met Ile Tyr Arg Asn Leu Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro Gln 
        35                  40                  45              


Ile Gln Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn Ile 
    50                  55                  60                  


Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu Ile Gln 
65                  70                  75                  80  


Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser Asp Met 
                85                  90                  95      


Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu Phe 
            100                 105                 110         


Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His Val Ser 
        115                 120                 125             


Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro 
                165                 170                 175     


Gly Leu Gly Glu Pro Arg Tyr Met Glu Val Gly Tyr Val Asp Asp Thr 
            180                 185                 190         


Glu Phe Val Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg Tyr Glu Pro 
        195                 200                 205             


Arg Ala Arg Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Arg Glu 
    210                 215                 220                 


Thr Gln Lys Ala Lys Gly Asn Glu Gln Ser Phe Arg Val Asp Leu Arg 
225                 230                 235                 240 


Thr Leu Leu Gly Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Ile 
                245                 250                 255     


Gln Val Ile Ser Gly Cys Glu Val Gly Ser Asp Gly Arg Leu Leu Arg 
            260                 265                 270         


Gly Tyr Gln Gln Tyr Ala Tyr Asp Gly Cys Asp Tyr Ile Ala Leu Asn 
        275                 280                 285             


Glu Asp Leu Lys Thr Trp Thr Ala Ala Asp Met Ala Ala Leu Ile Thr 
    290                 295                 300                 


Lys His Lys Trp Glu Gln Ala Gly Glu Ala Glu Arg Leu Arg Ala Tyr 
305                 310                 315                 320 


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly 
                325                 330                 335     


Asn Ala Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
            340                 345                 350         


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
        355                 360                 365             


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
    370                 375                 380                 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
385                 390                 395                 400 


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
                405                 410                 415     


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
            420                 425                 430         


Leu Arg Trp Glu Pro Pro Pro Ser Thr Ala Ser Gly Gly His His His 
        435                 440                 445             


His His His Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
    450                 455                 460                 


His 
465 


<210>  34
<211>  2218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BA DNA of Soluble single chain MHC: H2Kb molecule with YAMIYRNL 
       peptide anti MCSP scFv of 225.28S clone and tags nucleic acid 
       sequence

<400>  34
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtaa ggggttaaca       60

gtagcaggct tgaggtctgg acatatatat gggtgacaat gacatccact ttgcctttct      120

ctccacaggc gcgcacagtt acgccatgat ctaccggaac ctgggcggcg gaggatctgg      180

cggaggtgga agtgggggag gcggcagcat ccagaaaacc ccccagatcc aggtgtacag      240

ccggcacccc cccgagaacg gcaagcccaa catcctgaac tgctacgtga cccagttcca      300

cccccctcac atcgagatcc agatgctgaa gaatggcaag aagatcccca aggtcgagat      360

gagcgacatg agcttcagca aggactggtc cttctacatc ctggcccaca ccgagttcac      420

ccccaccgaa accgacacct acgcctgcag agtgaagcac gtgtccatgg ccgagcccaa      480

gaccgtgtac tgggaccggg atatgggcgg agggggtagc ggaggcggtg gttctggcgg      540

aggtggctca gggggagggg gatctggccc ccacagcctg cggtacttcg tgaccgccgt      600

gtccagacct ggcctgggcg agccccggta catggaagtg ggctacgtgg acgacaccga      660

gttcgtcaga ttcgacagcg acgccgagaa ccccagatac gagcccagag cccggtggat      720

ggaacaggaa ggccccgagt actgggagag agagacacag aaggccaagg gcaacgagca      780

gagcttccgg gtggacctgc ggaccctgct gggctactac aaccagagca agggcggcag      840

ccacaccatc caggtcatca gcggctgcga agtgggaagc gacggccggc tgctgcgggg      900

ctaccagcag tacgcctacg atggctgcga ctatatcgcc ctgaacgagg acctgaaaac      960

ctggacagcc gccgacatgg ccgccctgat caccaagcac aagtgggagc aggccgggga     1020

ggccgagaga ctgagagcct acctggaagg cacctgtgtg gaatggctga gaagatacct     1080

gaagaacggc aacgccacac tgctgagaac cgacagcccc aaggcccacg tgacccacca     1140

cagcagaccc gaggacaaag tgaccctgcg gtgctgggcc ctgggcttct accccgccga     1200

tatcaccctg acctggcagc tgaacggcga ggaactgatc caggacatgg aactggtgga     1260

aacccggcct gccggcgacg gcaccttcca gaaatgggcc agcgtggtgg tgcccctggg     1320

aaaagagcag tactacacct gtcacgtgta ccaccagggc ctgcccgagc ccctgaccct     1380

gagatgggag cctccaccta gcaccgccag cggcggacag gtcaaactgc agcagagcgg     1440

cggaggcctg gtgcagcctg gcggcagcat gaagctgagc tgcgtggtgt ccggcttcac     1500

cttcagcaac tactggatga actgggtccg acagagcccc gagaagggcc tggaatggat     1560

cgccgagatc cggctgaagt ccaacaactt cggccggtac tacgccgaga gcgtgaaggg     1620

cagattcacc atcagccggg acgacagcaa gagcagcgcc tacctgcaga tgatcaacct     1680

gcgggccgag gacaccggca tctactactg caccagctac ggcaactacg tgggccacta     1740

cttcgaccac tggggccagg gcaccaccgt gaccgtgtct agcggaggcg gaggatctgg     1800

cggaggtgga agtggcgggg gaggcagcga tatcgagctg acccagtccc ccaagttcat     1860

gagcaccagc gtgggcgacc gggtgtccgt gacatgcaag gccagccaga acgtggacac     1920

caacgtggcc tggtatcagc agaagcccgg ccagagccct gagcccctgc tgttcagcgc     1980

cagctacaga tacaccggcg tgcccgacag gttcaccggc agcggctctg gcaccgactt     2040

caccctgacc atctccaacg tgcagagcga ggacctggcc gagtacttct gccagcagta     2100

caacagctac cccctgacct ttggaggcgg caccaagctg gaaatcaagc gggcccatca     2160

tcaccatcac catggactta atgatatctt cgaggcgcag aagattgaat ggcactga       2218


<210>  35
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BA Protein Soluble fusion molecule: H2Kb molecule with YAMIYRNL 
       peptide anti MCSP scFv of 225.28S clone and tags amino acid 
       sequence

<400>  35

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Tyr Ala Met Ile Tyr Arg Asn Leu Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro Gln 
        35                  40                  45              


Ile Gln Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn Ile 
    50                  55                  60                  


Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu Ile Gln 
65                  70                  75                  80  


Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser Asp Met 
                85                  90                  95      


Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu Phe 
            100                 105                 110         


Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His Val Ser 
        115                 120                 125             


Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro 
                165                 170                 175     


Gly Leu Gly Glu Pro Arg Tyr Met Glu Val Gly Tyr Val Asp Asp Thr 
            180                 185                 190         


Glu Phe Val Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg Tyr Glu Pro 
        195                 200                 205             


Arg Ala Arg Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Arg Glu 
    210                 215                 220                 


Thr Gln Lys Ala Lys Gly Asn Glu Gln Ser Phe Arg Val Asp Leu Arg 
225                 230                 235                 240 


Thr Leu Leu Gly Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Ile 
                245                 250                 255     


Gln Val Ile Ser Gly Cys Glu Val Gly Ser Asp Gly Arg Leu Leu Arg 
            260                 265                 270         


Gly Tyr Gln Gln Tyr Ala Tyr Asp Gly Cys Asp Tyr Ile Ala Leu Asn 
        275                 280                 285             


Glu Asp Leu Lys Thr Trp Thr Ala Ala Asp Met Ala Ala Leu Ile Thr 
    290                 295                 300                 


Lys His Lys Trp Glu Gln Ala Gly Glu Ala Glu Arg Leu Arg Ala Tyr 
305                 310                 315                 320 


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly 
                325                 330                 335     


Asn Ala Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
            340                 345                 350         


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
        355                 360                 365             


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
    370                 375                 380                 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
385                 390                 395                 400 


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
                405                 410                 415     


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
            420                 425                 430         


Leu Arg Trp Glu Pro Pro Pro Ser Thr Ala Ser Gly Gly Gln Val Lys 
        435                 440                 445             


Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Met Lys 
    450                 455                 460                 


Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr Trp Met Asn 
465                 470                 475                 480 


Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile Ala Glu Ile 
                485                 490                 495     


Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu Ser Val Lys 
            500                 505                 510         


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Ala Tyr Leu 
        515                 520                 525             


Gln Met Ile Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Thr 
    530                 535                 540                 


Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp Gly Gln Gly 
545                 550                 555                 560 


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe 
            580                 585                 590         


Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser 
        595                 600                 605             


Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    610                 615                 620                 


Ser Pro Glu Pro Leu Leu Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val 
625                 630                 635                 640 


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                645                 650                 655     


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln 
            660                 665                 670         


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        675                 680                 685             


Lys Arg Ala His His His His His His Gly Leu Asn Asp Ile Phe Glu 
    690                 695                 700                 


Ala Gln Lys Ile Glu Trp His 
705                 710     


<210>  36
<211>  2176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M15 DNA of Soluble single chain MHC: H2Kb molecule with YAMIYRNL 
       peptide anti MCSP scFv of 225.28S clone and tags nucleic acid 
       sequence

<400>  36
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtaa ggggttaaca       60

gtagcaggct tgaggtctgg acatatatat gggtgacaat gacatccact ttgcctttct      120

ctccacaggc gcgcacagtt acgccatgat ctaccggaac ctgggcggcg gaggatctgg      180

cggaggtgga agtgggggag gcggcagcat ccagaaaacc ccccagatcc aggtgtacag      240

ccggcacccc cccgagaacg gcaagcccaa catcctgaac tgctacgtga cccagttcca      300

cccccctcac atcgagatcc agatgctgaa gaatggcaag aagatcccca aggtcgagat      360

gagcgacatg agcttcagca aggactggtc cttctacatc ctggcccaca ccgagttcac      420

ccccaccgaa accgacacct acgcctgcag agtgaagcac gtgtccatgg ccgagcccaa      480

gaccgtgtac tgggaccggg atatgggcgg agggggtagc ggaggcggtg gttctggcgg      540

aggtggctca gggggagggg gatctggccc ccacagcctg cggtacttcg tgaccgccgt      600

gtccagacct ggcctgggcg agccccggta catggaagtg ggctacgtgg acgacaccga      660

gttcgtcaga ttcgacagcg acgccgagaa ccccagatac gagcccagag cccggtggat      720

ggaacaggaa ggccccgagt actgggagag agagacacag aaggccaagg gcaacgagca      780

gagcttccgg gtggacctgc ggaccctgct gggctactac aaccagagca agggcggcag      840

ccacaccatc caggtcatca gcggctgcga agtgggaagc gacggccggc tgctgcgggg      900

ctaccagcag tacgcctacg atggctgcga ctatatcgcc ctgaacgagg acctgaaaac      960

ctggacagcc gccgacatgg ccgccctgat caccaagcac aagtgggagc aggccgggga     1020

ggccgagaga ctgagagcct acctggaagg cacctgtgtg gaatggctga gaagatacct     1080

gaagaacggc aacgccacac tgctgagaac cgacagcccc aaggcccacg tgacccacca     1140

cagcagaccc gaggacaaag tgaccctgcg gtgctgggcc ctgggcttct accccgccga     1200

tatcaccctg acctggcagc tgaacggcga ggaactgatc caggacatgg aactggtgga     1260

aacccggcct gccggcgacg gcaccttcca gaaatgggcc agcgtggtgg tgcccctggg     1320

aaaagagcag tactacacct gtcacgtgta ccaccagggc ctgcccgagc ccctgaccct     1380

gagatgggag cctccaccta gcaccgccag cggcggacag gtcaaactgc agcagagcgg     1440

cggaggcctg gtgcagcctg gcggcagcat gaagctgagc tgcgtggtgt ccggcttcac     1500

cttcagcaac tactggatga actgggtccg acagagcccc gagaagggcc tggaatggat     1560

cgccgagatc cggctgaagt ccaacaactt cggccggtac tacgccgaga gcgtgaaggg     1620

cagattcacc atcagccggg acgacagcaa gagcagcgcc tacctgcaga tgatcaacct     1680

gcgggccgag gacaccggca tctactactg caccagctac ggcaactacg tgggccacta     1740

cttcgaccac tggggccagg gcaccaccgt gaccgtgtct agcggaggcg gaggatctgg     1800

cggaggtgga agtggcgggg gaggcagcga tatcgagctg acccagtccc ccaagttcat     1860

gagcaccagc gtgggcgacc gggtgtccgt gacatgcaag gccagccaga acgtggacac     1920

caacgtggcc tggtatcagc agaagcccgg ccagagccct gagcccctgc tgttcagcgc     1980

cagctacaga tacaccggcg tgcccgacag gttcaccggc agcggctctg gcaccgactt     2040

caccctgacc atctccaacg tgcagagcga ggacctggcc gagtacttct gccagcagta     2100

caacagctac cccctgacct ttggaggcgg caccaagctg gaaatcaagc gggcccatca     2160

tcaccatcac cattga                                                     2176


<210>  37
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M15 Soluble fusion molecule: H2Kb molecule with YAMIYRNL peptide 
       anti MCSP scFv of 225.28S clone and tags amino acid sequence

<400>  37

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Tyr Ala Met Ile Tyr Arg Asn Leu Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro Gln 
        35                  40                  45              


Ile Gln Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn Ile 
    50                  55                  60                  


Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu Ile Gln 
65                  70                  75                  80  


Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser Asp Met 
                85                  90                  95      


Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu Phe 
            100                 105                 110         


Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His Val Ser 
        115                 120                 125             


Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro 
                165                 170                 175     


Gly Leu Gly Glu Pro Arg Tyr Met Glu Val Gly Tyr Val Asp Asp Thr 
            180                 185                 190         


Glu Phe Val Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg Tyr Glu Pro 
        195                 200                 205             


Arg Ala Arg Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Arg Glu 
    210                 215                 220                 


Thr Gln Lys Ala Lys Gly Asn Glu Gln Ser Phe Arg Val Asp Leu Arg 
225                 230                 235                 240 


Thr Leu Leu Gly Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Ile 
                245                 250                 255     


Gln Val Ile Ser Gly Cys Glu Val Gly Ser Asp Gly Arg Leu Leu Arg 
            260                 265                 270         


Gly Tyr Gln Gln Tyr Ala Tyr Asp Gly Cys Asp Tyr Ile Ala Leu Asn 
        275                 280                 285             


Glu Asp Leu Lys Thr Trp Thr Ala Ala Asp Met Ala Ala Leu Ile Thr 
    290                 295                 300                 


Lys His Lys Trp Glu Gln Ala Gly Glu Ala Glu Arg Leu Arg Ala Tyr 
305                 310                 315                 320 


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly 
                325                 330                 335     


Asn Ala Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
            340                 345                 350         


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
        355                 360                 365             


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
    370                 375                 380                 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
385                 390                 395                 400 


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
                405                 410                 415     


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
            420                 425                 430         


Leu Arg Trp Glu Pro Pro Pro Ser Thr Ala Ser Gly Gly Gln Val Lys 
        435                 440                 445             


Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Met Lys 
    450                 455                 460                 


Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr Trp Met Asn 
465                 470                 475                 480 


Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile Ala Glu Ile 
                485                 490                 495     


Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu Ser Val Lys 
            500                 505                 510         


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Ala Tyr Leu 
        515                 520                 525             


Gln Met Ile Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Thr 
    530                 535                 540                 


Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp Gly Gln Gly 
545                 550                 555                 560 


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe 
            580                 585                 590         


Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser 
        595                 600                 605             


Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    610                 615                 620                 


Ser Pro Glu Pro Leu Leu Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val 
625                 630                 635                 640 


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                645                 650                 655     


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln 
            660                 665                 670         


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        675                 680                 685             


Lys Arg Ala His His His His His His 
    690                 695         


<210>  38
<211>  1483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CG DNA of Soluble single chain MHC: H2Kd molecule with TYQRTRALV 
       peptide with Tags, without the scFv nucleic acid sequence

<400>  38
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtaa ggggttaaca       60

gtagcaggct tgaggtctgg acatatatat gggtgacaat gacatccact ttgcctttct      120

ctccacaggc gcgcacagta cctaccagcg gaccagagcc ctcgtgggcg gcggaggatc      180

tggcggaggt ggaagtgggg gaggcggcag catccagaaa accccccaga tccaggtgta      240

cagccggcac ccccccgaga acggcaagcc caacatcctg aactgctacg tgacccagtt      300

ccacccccct cacatcgaga tccagatgct gaagaatggc aagaagatcc ccaaggtcga      360

gatgagcgac atgagcttca gcaaggactg gtccttctac atcctggccc acaccgagtt      420

cacccccacc gaaaccgaca cctacgcctg cagagtgaag cacgtgtcca tggccgagcc      480

caagaccgtg tactgggacc gggatatggg cggagggggt agcggaggcg gtggttctgg      540

cggaggtggc tcagggggag ggggatctgg cccccacagc ctgcggtact tcgtgaccgc      600

cgtgtccaga cctggcctgg gcgagcctag attcattgcc gtgggctacg tggacgacac      660

ccagttcgtc agattcgaca gcgacgccga caacccccgc ttcgagccca gagccccctg      720

gatggaacag gaaggccccg agtactggga ggaacagacc cagcgggcca agagcgacga      780

gcagtggttc cgggtgtccc tgcggaccgc ccagcggtac tacaaccaga gcaagggcgg      840

cagccacacc ttccagcgga tgttcggctg cgacgtgggc agcgactggc ggctgctgag      900

aggctaccag cagttcgcct acgacggccg ggactatatc gccctgaacg aggacctgaa      960

aacctggaca gccgccgaca ctgccgccct gatcaccaga cggaagtggg aacaggccgg     1020

cgacgctgag tactaccggg cctacctgga aggcgagtgc gtggaatggc tgcggagata     1080

tctggaactg ggcaacgaga cactgctgag gaccgacagc cccaaggccc acgtgaccta     1140

ccaccccaga tcccaggtgg acgtgaccct gagatgctgg gccctgggct tctaccccgc     1200

cgatatcacc ctgacctggc agctgaacgg cgaggatctg acccaggaca tggaactcgt     1260

ggaaacccgg cctgccgggg acggcacctt tcagaaatgg gccgctgtgg tggtgcccct     1320

gggcaaagag cagaactaca cctgtcacgt gcaccacaag ggcctgcccg agcctctgac     1380

cctgcggtgg aagctgcctc ctagcaccgc cagcggcgga catcatcacc atcaccatgg     1440

acttaatgat atcttcgagg cgcagaagat tgaatggcac tga                       1483


<210>  39
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CG Protein of Soluble single chain MHC: H2Kd molecule with 
       TYQRTRALV peptide with Tags, without the scFv amino acid sequence

<400>  39

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Thr Tyr Gln Arg Thr Arg Ala Leu Val Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro 
        35                  40                  45              


Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn 
    50                  55                  60                  


Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu Ile 
65                  70                  75                  80  


Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser Asp 
                85                  90                  95      


Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu 
            100                 105                 110         


Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His Val 
        115                 120                 125             


Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg 
                165                 170                 175     


Pro Gly Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp 
            180                 185                 190         


Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu 
        195                 200                 205             


Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu 
    210                 215                 220                 


Gln Thr Gln Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu 
225                 230                 235                 240 


Arg Thr Ala Gln Arg Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr 
                245                 250                 255     


Phe Gln Arg Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu 
            260                 265                 270         


Arg Gly Tyr Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu 
        275                 280                 285             


Asn Glu Asp Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile 
    290                 295                 300                 


Thr Arg Arg Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala 
305                 310                 315                 320 


Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu 
                325                 330                 335     


Gly Asn Glu Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr 
            340                 345                 350         


Tyr His Pro Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu 
        355                 360                 365             


Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu 
    370                 375                 380                 


Asp Leu Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp 
385                 390                 395                 400 


Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu 
                405                 410                 415     


Gln Asn Tyr Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu 
            420                 425                 430         


Thr Leu Arg Trp Lys Leu Pro Pro Ser Thr Ala Ser Gly Gly His His 
        435                 440                 445             


His His His His Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
    450                 455                 460                 


Trp His 
465     


<210>  40
<211>  2221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BA DNA of Soluble single chain MHC: H2Kd molecule with TYQRTRALV 
       peptide anti MCSP scFv of 225.28S clone and tags nucleic acid 
       sequence

<400>  40
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtaa ggggttaaca       60

gtagcaggct tgaggtctgg acatatatat gggtgacaat gacatccact ttgcctttct      120

ctccacaggc gcgcacagta cctaccagcg gaccagagcc ctcgtgggcg gcggaggatc      180

tggcggaggt ggaagtgggg gaggcggcag catccagaaa accccccaga tccaggtgta      240

cagccggcac ccccccgaga acggcaagcc caacatcctg aactgctacg tgacccagtt      300

ccacccccct cacatcgaga tccagatgct gaagaatggc aagaagatcc ccaaggtcga      360

gatgagcgac atgagcttca gcaaggactg gtccttctac atcctggccc acaccgagtt      420

cacccccacc gaaaccgaca cctacgcctg cagagtgaag cacgtgtcca tggccgagcc      480

caagaccgtg tactgggacc gggatatggg cggagggggt agcggaggcg gtggttctgg      540

cggaggtggc tcagggggag ggggatctgg cccccacagc ctgcggtact tcgtgaccgc      600

cgtgtccaga cctggcctgg gcgagcctag attcattgcc gtgggctacg tggacgacac      660

ccagttcgtc agattcgaca gcgacgccga caacccccgc ttcgagccca gagccccctg      720

gatggaacag gaaggccccg agtactggga ggaacagacc cagcgggcca agagcgacga      780

gcagtggttc cgggtgtccc tgcggaccgc ccagcggtac tacaaccaga gcaagggcgg      840

cagccacacc ttccagcgga tgttcggctg cgacgtgggc agcgactggc ggctgctgag      900

aggctaccag cagttcgcct acgacggccg ggactatatc gccctgaacg aggacctgaa      960

aacctggaca gccgccgaca ctgccgccct gatcaccaga cggaagtggg aacaggccgg     1020

cgacgctgag tactaccggg cctacctgga aggcgagtgc gtggaatggc tgcggagata     1080

tctggaactg ggcaacgaga cactgctgag gaccgacagc cccaaggccc acgtgaccta     1140

ccaccccaga tcccaggtgg acgtgaccct gagatgctgg gccctgggct tctaccccgc     1200

cgatatcacc ctgacctggc agctgaacgg cgaggatctg acccaggaca tggaactcgt     1260

ggaaacccgg cctgccgggg acggcacctt tcagaaatgg gccgctgtgg tggtgcccct     1320

gggcaaagag cagaactaca cctgtcacgt gcaccacaag ggcctgcccg agcctctgac     1380

cctgcggtgg aagctgcctc ctagcaccgc cagcggcgga caggtcaaac tgcagcagag     1440

cggcggaggc ctggtgcagc ctggcggcag catgaagctg agctgcgtgg tgtccggctt     1500

caccttcagc aactactgga tgaactgggt ccgacagagc cccgagaagg gcctggaatg     1560

gatcgccgag atccggctga agtccaacaa cttcggccgg tactacgccg agagcgtgaa     1620

gggcagattc accatcagcc gggacgacag caagagcagc gcctacctgc agatgatcaa     1680

cctgcgggcc gaggacaccg gcatctacta ctgcaccagc tacggcaact acgtgggcca     1740

ctacttcgac cactggggcc agggcaccac cgtgaccgtg tctagcggag gcggaggatc     1800

tggcggaggt ggaagtggcg ggggaggcag cgatatcgag ctgacccagt cccccaagtt     1860

catgagcacc agcgtgggcg accgggtgtc cgtgacatgc aaggccagcc agaacgtgga     1920

caccaacgtg gcctggtatc agcagaagcc cggccagagc cctgagcccc tgctgttcag     1980

cgccagctac agatacaccg gcgtgcccga caggttcacc ggcagcggct ctggcaccga     2040

cttcaccctg accatctcca acgtgcagag cgaggacctg gccgagtact tctgccagca     2100

gtacaacagc taccccctga cctttggagg cggcaccaag ctggaaatca agcgggccca     2160

tcatcaccat caccatggac ttaatgatat cttcgaggcg cagaagattg aatggcactg     2220

a                                                                     2221


<210>  41
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BA Protein of Soluble single chain MHC: H2Kd molecule with 
       TYQRTRALV peptide anti MCSP scFv of 225.28S clone and tags amino 
       acid sequence

<400>  41

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Thr Tyr Gln Arg Thr Arg Ala Leu Val Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro 
        35                  40                  45              


Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn 
    50                  55                  60                  


Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu Ile 
65                  70                  75                  80  


Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser Asp 
                85                  90                  95      


Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu 
            100                 105                 110         


Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His Val 
        115                 120                 125             


Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg 
                165                 170                 175     


Pro Gly Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp 
            180                 185                 190         


Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu 
        195                 200                 205             


Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu 
    210                 215                 220                 


Gln Thr Gln Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu 
225                 230                 235                 240 


Arg Thr Ala Gln Arg Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr 
                245                 250                 255     


Phe Gln Arg Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu 
            260                 265                 270         


Arg Gly Tyr Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu 
        275                 280                 285             


Asn Glu Asp Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile 
    290                 295                 300                 


Thr Arg Arg Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala 
305                 310                 315                 320 


Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu 
                325                 330                 335     


Gly Asn Glu Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr 
            340                 345                 350         


Tyr His Pro Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu 
        355                 360                 365             


Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu 
    370                 375                 380                 


Asp Leu Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp 
385                 390                 395                 400 


Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu 
                405                 410                 415     


Gln Asn Tyr Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu 
            420                 425                 430         


Thr Leu Arg Trp Lys Leu Pro Pro Ser Thr Ala Ser Gly Gly Gln Val 
        435                 440                 445             


Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Met 
    450                 455                 460                 


Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr Trp Met 
465                 470                 475                 480 


Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile Ala Glu 
                485                 490                 495     


Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu Ser Val 
            500                 505                 510         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Ala Tyr 
        515                 520                 525             


Leu Gln Met Ile Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys 
    530                 535                 540                 


Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp Gly Gln 
545                 550                 555                 560 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Lys 
            580                 585                 590         


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala 
        595                 600                 605             


Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    610                 615                 620                 


Gln Ser Pro Glu Pro Leu Leu Phe Ser Ala Ser Tyr Arg Tyr Thr Gly 
625                 630                 635                 640 


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                645                 650                 655     


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
            660                 665                 670         


Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        675                 680                 685             


Ile Lys Arg Ala His His His His His His Gly Leu Asn Asp Ile Phe 
    690                 695                 700                 


Glu Ala Gln Lys Ile Glu Trp His 
705                 710         


<210>  42
<211>  2179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M15 DNA of Soluble single chain MHC: H2Kd molecule with TYQRTRALV
       peptide anti MCSP scFv of 225.28S clone and tags nucleic acid 
       sequence

<400>  42
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtaa ggggttaaca       60

gtagcaggct tgaggtctgg acatatatat gggtgacaat gacatccact ttgcctttct      120

ctccacaggc gcgcacagta cctaccagcg gaccagagcc ctcgtgggcg gcggaggatc      180

tggcggaggt ggaagtgggg gaggcggcag catccagaaa accccccaga tccaggtgta      240

cagccggcac ccccccgaga acggcaagcc caacatcctg aactgctacg tgacccagtt      300

ccacccccct cacatcgaga tccagatgct gaagaatggc aagaagatcc ccaaggtcga      360

gatgagcgac atgagcttca gcaaggactg gtccttctac atcctggccc acaccgagtt      420

cacccccacc gaaaccgaca cctacgcctg cagagtgaag cacgtgtcca tggccgagcc      480

caagaccgtg tactgggacc gggatatggg cggagggggt agcggaggcg gtggttctgg      540

cggaggtggc tcagggggag ggggatctgg cccccacagc ctgcggtact tcgtgaccgc      600

cgtgtccaga cctggcctgg gcgagcctag attcattgcc gtgggctacg tggacgacac      660

ccagttcgtc agattcgaca gcgacgccga caacccccgc ttcgagccca gagccccctg      720

gatggaacag gaaggccccg agtactggga ggaacagacc cagcgggcca agagcgacga      780

gcagtggttc cgggtgtccc tgcggaccgc ccagcggtac tacaaccaga gcaagggcgg      840

cagccacacc ttccagcgga tgttcggctg cgacgtgggc agcgactggc ggctgctgag      900

aggctaccag cagttcgcct acgacggccg ggactatatc gccctgaacg aggacctgaa      960

aacctggaca gccgccgaca ctgccgccct gatcaccaga cggaagtggg aacaggccgg     1020

cgacgctgag tactaccggg cctacctgga aggcgagtgc gtggaatggc tgcggagata     1080

tctggaactg ggcaacgaga cactgctgag gaccgacagc cccaaggccc acgtgaccta     1140

ccaccccaga tcccaggtgg acgtgaccct gagatgctgg gccctgggct tctaccccgc     1200

cgatatcacc ctgacctggc agctgaacgg cgaggatctg acccaggaca tggaactcgt     1260

ggaaacccgg cctgccgggg acggcacctt tcagaaatgg gccgctgtgg tggtgcccct     1320

gggcaaagag cagaactaca cctgtcacgt gcaccacaag ggcctgcccg agcctctgac     1380

cctgcggtgg aagctgcctc ctagcaccgc cagcggcgga caggtcaaac tgcagcagag     1440

cggcggaggc ctggtgcagc ctggcggcag catgaagctg agctgcgtgg tgtccggctt     1500

caccttcagc aactactgga tgaactgggt ccgacagagc cccgagaagg gcctggaatg     1560

gatcgccgag atccggctga agtccaacaa cttcggccgg tactacgccg agagcgtgaa     1620

gggcagattc accatcagcc gggacgacag caagagcagc gcctacctgc agatgatcaa     1680

cctgcgggcc gaggacaccg gcatctacta ctgcaccagc tacggcaact acgtgggcca     1740

ctacttcgac cactggggcc agggcaccac cgtgaccgtg tctagcggag gcggaggatc     1800

tggcggaggt ggaagtggcg ggggaggcag cgatatcgag ctgacccagt cccccaagtt     1860

catgagcacc agcgtgggcg accgggtgtc cgtgacatgc aaggccagcc agaacgtgga     1920

caccaacgtg gcctggtatc agcagaagcc cggccagagc cctgagcccc tgctgttcag     1980

cgccagctac agatacaccg gcgtgcccga caggttcacc ggcagcggct ctggcaccga     2040

cttcaccctg accatctcca acgtgcagag cgaggacctg gccgagtact tctgccagca     2100

gtacaacagc taccccctga cctttggagg cggcaccaag ctggaaatca agcgggccca     2160

tcatcaccat caccattga                                                  2179


<210>  43
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M15 Protein of Soluble single chain MHC: H2Kd molecule with 
       TYQRTRALV peptide anti MCSP scFv of 225.28S clone and tags amino 
       acid sequence

<400>  43

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Thr Tyr Gln Arg Thr Arg Ala Leu Val Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro 
        35                  40                  45              


Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn 
    50                  55                  60                  


Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu Ile 
65                  70                  75                  80  


Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser Asp 
                85                  90                  95      


Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu 
            100                 105                 110         


Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His Val 
        115                 120                 125             


Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg 
                165                 170                 175     


Pro Gly Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp 
            180                 185                 190         


Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu 
        195                 200                 205             


Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu 
    210                 215                 220                 


Gln Thr Gln Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu 
225                 230                 235                 240 


Arg Thr Ala Gln Arg Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr 
                245                 250                 255     


Phe Gln Arg Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu 
            260                 265                 270         


Arg Gly Tyr Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu 
        275                 280                 285             


Asn Glu Asp Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile 
    290                 295                 300                 


Thr Arg Arg Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala 
305                 310                 315                 320 


Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu 
                325                 330                 335     


Gly Asn Glu Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr 
            340                 345                 350         


Tyr His Pro Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu 
        355                 360                 365             


Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu 
    370                 375                 380                 


Asp Leu Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp 
385                 390                 395                 400 


Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu 
                405                 410                 415     


Gln Asn Tyr Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu 
            420                 425                 430         


Thr Leu Arg Trp Lys Leu Pro Pro Ser Thr Ala Ser Gly Gly Gln Val 
        435                 440                 445             


Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Met 
    450                 455                 460                 


Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn Tyr Trp Met 
465                 470                 475                 480 


Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile Ala Glu 
                485                 490                 495     


Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu Ser Val 
            500                 505                 510         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Ala Tyr 
        515                 520                 525             


Leu Gln Met Ile Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys 
    530                 535                 540                 


Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp Gly Gln 
545                 550                 555                 560 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Lys 
            580                 585                 590         


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala 
        595                 600                 605             


Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    610                 615                 620                 


Gln Ser Pro Glu Pro Leu Leu Phe Ser Ala Ser Tyr Arg Tyr Thr Gly 
625                 630                 635                 640 


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                645                 650                 655     


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
            660                 665                 670         


Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        675                 680                 685             


Ile Lys Arg Ala His His His His His His 
    690                 695             


<210>  44
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  44

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr 
    50                  55                  60                  


Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  45
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala His Ser Gln Thr Asp Arg Glu Ser Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Thr Ala His Glu Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Arg Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  46
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Ser His Ser Met Arg Tyr Phe Thr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Leu Gln Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      


Met Met Tyr Gly Cys His Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  47
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala His Ser Gln Thr Asp Arg Glu Ser Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      


Met Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  48
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Thr Ala His Glu Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  49
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Ser Gln 
            20                  25                  30          


Phe Val Gln Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Glu Pro Glu Tyr Trp Asp Glu Glu Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala His Ser Gln Thr Asn Arg Ala Asn Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Ile Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Arg Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  50
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Thr Ala His Glu Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Arg Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  51
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  51

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  52
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  52

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Thr Ala His Glu Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Arg Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  53
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Leu Gln Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Thr Ala His Glu Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Arg Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp 
            180             


<210>  54
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      


Met Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  55
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala His Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      


Met Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  56
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  56

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Lys Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Met Lys Ala His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Val His Ala Ala Glu Gln Arg Arg Val Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  57
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Ser His Ser Met Arg Tyr Phe Thr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Arg Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala His Ser Gln Ile Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      


Met Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  58
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Cys Lys Thr Asn Thr Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg His Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  59
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Gly Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg His Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  60
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Asn Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  61
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Cys Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Thr Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  62
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  62

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Cys Lys Thr Asn Thr Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Thr Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  63
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Ser His Ser Met Arg Tyr Phe His Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Asp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Thr Leu Glu Arg Ala 
            180         


<210>  64
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Asp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Thr Leu Glu Arg Ala 
            180         


<210>  65
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  65

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Phe Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg 
            180     


<210>  66
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Gln 
    130                 135                 140                 


Arg Lys Leu Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Lys Leu Glu Arg Ala 
            180         


<210>  67
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  67

Gly Ser His Ser Met Arg Tyr Phe His Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asn Gln Leu Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  68
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  68

Gly Ser His Ser Met Arg Tyr Phe His Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asn Gln Leu Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  69
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln 
                85                  90                  95      


Thr Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg His Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  70
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  70

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Phe Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  71
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  71

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln 
                85                  90                  95      


Thr Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Leu Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  72
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  72

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln 
                85                  90                  95      


Thr Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Leu Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  73
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  73

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln 
                85                  90                  95      


Thr Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Leu Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  74
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  74

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Met Ala Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Asn Met Lys Ala Ser Ala Gln Thr Tyr Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Val Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  75
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  75

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Asn Met Lys Ala Ser Ala Gln Thr Tyr Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  76
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  76

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Phe Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln 
                85                  90                  95      


Thr Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Leu Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  77
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  77

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Thr Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  78
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  78

Gly Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Val Gly Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Trp Gln 
                85                  90                  95      


Thr Met Tyr Gly Cys Asp Met Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg His Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  79
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  79

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Phe Lys Thr Asn Thr Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln 
                85                  90                  95      


Thr Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg His Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  80
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  80

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Phe Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Leu Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Asp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Asp Leu Cys Val Glu Ser Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala 
            180         


<210>  81
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  81

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Gln 
    130                 135                 140                 


Arg Lys Leu Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Lys Leu Glu Arg Ala 
            180         


<210>  82
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  82
atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct       60

atccagcgta ctccaaagat tcaggtttac tcacgtcatc cagcagagaa tggaaagtca      120

aatttcctga attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg      180

aagaatggag agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg      240

tctttctatc tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc      300

cgtgtgaacc atgtgacttt gtcacagccc aagatagtta agtgggatcg agacatg         357


<210>  83
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  83

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  84
<211>  9
<212>  PRT
<213>  Ebola virus

<400>  84

Ala Tyr Gln Gly Asp Tyr Lys Leu Phe 
1               5                   


<210>  85
<211>  10
<212>  PRT
<213>  Dengue virus

<400>  85

Arg Phe Leu Glu Phe Glu Ala Leu Gly Phe 
1               5                   10  


<210>  86
<211>  9
<212>  PRT
<213>  Vaccinia virus

<400>  86

Val Trp Ile Asn Asn Ser Trp Lys Phe 
1               5                   


<210>  87
<211>  9
<212>  PRT
<213>  Vaccinia virus

<400>  87

Thr Tyr Asn Asp His Ile Val Asn Leu 
1               5                   


<210>  88
<211>  10
<212>  PRT
<213>  Human herpesvirus 5

<400>  88

Ala Tyr Ala Gln Lys Ile Phe Lys Ile Leu 
1               5                   10  


<210>  89
<211>  9
<212>  PRT
<213>  Human herpesvirus 4

<400>  89

Pro Tyr Leu Phe Trp Leu Ala Ala Ile 
1               5                   


<210>  90
<211>  9
<212>  PRT
<213>  Yellow fever virus

<400>  90

Ile Tyr Gly Ile Phe Gln Ser Thr Phe 
1               5                   


<210>  91
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  91

Leu Trp Met Arg Leu Leu Pro Leu Leu 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  92

Phe Tyr Ile Gln Met Cys Thr Glu Leu 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Plasmodium falciparum

<400>  93

Ser Phe Leu Phe Val Glu Ala Leu Phe 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  Plasmodium falciparum

<400>  94

Val Phe Asn Val Val Asn Ser Ser Ile 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  95

Tyr Phe Asp Pro Ala Asn Gly Lys Phe 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  96

Tyr Tyr Leu Glu Lys Ala Asn Lys Ile 
1               5                   


<210>  97
<211>  10
<212>  PRT
<213>  Influenza A virus

<400>  97

Phe Tyr Arg Tyr Gly Phe Val Ala Asn Phe 
1               5                   10  


<210>  98
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  98

Lys Tyr Phe Asp Glu His Tyr Glu Tyr 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Dengue virus

<400>  99

Ile Gln Lys Glu Thr Leu Val Thr Phe 
1               5                   


<210>  100
<211>  10
<212>  PRT
<213>  Dengue virus

<400>  100

Ile Gln Met Ser Ser Gly Asn Leu Leu Phe 
1               5                   10  


<210>  101
<211>  9
<212>  PRT
<213>  Dengue virus

<400>  101

Ser Tyr Ser Met Cys Thr Gly Lys Phe 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  102

Ala Tyr Val Pro Gly Phe Ala His Ile 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  103

Lys Tyr Leu Ser Val Gln Gly Gln Phe 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  104

Lys Tyr Gln Glu Val Thr Asn Asn Leu 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  105

Leu Tyr Asp Pro Val Ile Ser Lys Leu 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  106

Arg Tyr Ile Ala Asn Thr Val Glu Leu 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  107

Arg Tyr Leu Glu Gln Leu His Gln Leu 
1               5                   


<210>  108
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of hCG Protein of Soluble single chain HLA-A*23:01:01: 
       molecule with PYLFWLAAI peptide with Tags, without the scFv amino
       acid sequence

<400>  108

Pro Tyr Leu Phe Trp Leu Ala Ala Ile Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly Arg 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr Gly 
        195                 200                 205             


Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
    210                 215                 220                 


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Met 
225                 230                 235                 240 


Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly Tyr 
                245                 250                 255     


His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln Arg 
        275                 280                 285             


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
305                 310                 315                 320 


Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His Pro 
                325                 330                 335     


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
        355                 360                 365             


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
                405                 410                 415     


Trp Glu Ala Ser Gly Gly His His His His His His Gly Leu Asn Asp 
            420                 425                 430         


Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
        435                 440         


<210>  109
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of hBAScFv Protein of Soluble single chain 
       HLA-A*23:01:01: molecule with PYLFWLAAI peptide and an anti MSLN 
       ScFv with Tags amino acid sequence

<400>  109

Pro Tyr Leu Phe Trp Leu Ala Ala Ile Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly Arg 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr Gly 
        195                 200                 205             


Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
    210                 215                 220                 


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Met 
225                 230                 235                 240 


Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly Tyr 
                245                 250                 255     


His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln Arg 
        275                 280                 285             


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
305                 310                 315                 320 


Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His Pro 
                325                 330                 335     


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
        355                 360                 365             


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
                405                 410                 415     


Trp Glu Ala Ser Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Glu 
            420                 425                 430         


Leu Glu Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        435                 440                 445             


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly 
    450                 455                 460                 


Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser 
465                 470                 475                 480 


Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys 
                485                 490                 495     


Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp 
            500                 505                 510         


Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe 
        515                 520                 525             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu 
545                 550                 555                 560 


Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr 
                565                 570                 575     


Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln 
            580                 585                 590         


Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
        595                 600                 605             


Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn 
    610                 615                 620                 


Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr 
625                 630                 635                 640 


Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly 
                645                 650                 655     


Thr Lys Leu Glu Ile Lys His His His His His His Gly Leu Asn Asp 
            660                 665                 670         


Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
        675                 680         


<210>  110
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of hM15ScFv Protein of Soluble single chain 
       HLA-A*23:01:01: molecule with PYLFWLAAI peptide and an anti MSLN 
       Fab with Tags amino acis sequence

<400>  110

Pro Tyr Leu Phe Trp Leu Ala Ala Ile Pro Glu Pro Thr Ile Asp Glu 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile 
            20                  25                  30          


Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn 
        35                  40                  45              


Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser 
    50                  55                  60                  


Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val 
65                  70                  75                  80  


Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu 
                85                  90                  95      


Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg 
            100                 105                 110         


Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg 
        115                 120                 125             


Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Ser Thr 
145                 150                 155                 160 


Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly 
                165                 170                 175     


Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser 
            180                 185                 190         


Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu 
        195                 200                 205             


Tyr Trp Asp Glu Glu Thr Gly Lys Val Lys Ala His Ser Gln Thr Asp 
    210                 215                 220                 


Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala 
225                 230                 235                 240 


Gly Ser His Thr Leu Gln Met Met Phe Gly Cys Asp Val Gly Ser Asp 
                245                 250                 255     


Gly Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp 
            260                 265                 270         


Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met 
        275                 280                 285             


Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu 
    290                 295                 300                 


Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Asp Gly Leu Arg Arg 
305                 310                 315                 320 


Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys 
                325                 330                 335     


Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg 
            340                 345                 350         


Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln 
        355                 360                 365             


Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg 
    370                 375                 380                 


Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro 
385                 390                 395                 400 


Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu 
                405                 410                 415     


Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ser Gly Gly Gln Val Gln 
            420                 425                 430         


Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys 
        435                 440                 445             


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
    450                 455                 460                 


Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile 
465                 470                 475                 480 


Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys 
                485                 490                 495     


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu 
            500                 505                 510         


Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly 
        515                 520                 525             


Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
    530                 535                 540                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
                565                 570                 575     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
            580                 585                 590         


Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
        595                 600                 605             


Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe 
    610                 615                 620                 


Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val 
625                 630                 635                 640 


Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His 
                645                 650                 655     


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys His His His 
            660                 665                 670         


His His His 
        675 


<210>  111
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of hBAFab(human Kappa) Protein of Soluble single chain 
       HLA-A*23:01:01: molecule with PYLFWLAAI peptide and an anti MSLN 
       ScFv with Tags. T cell Engaging domain and Fab Heavy Chain

<400>  111

Pro Tyr Leu Phe Trp Leu Ala Ala Ile Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly Arg 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr Gly 
        195                 200                 205             


Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
    210                 215                 220                 


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Met 
225                 230                 235                 240 


Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly Tyr 
                245                 250                 255     


His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln Arg 
        275                 280                 285             


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
305                 310                 315                 320 


Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His Pro 
                325                 330                 335     


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
        355                 360                 365             


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
                405                 410                 415     


Trp Glu Ala Ser Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Glu 
            420                 425                 430         


Leu Glu Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        435                 440                 445             


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly 
    450                 455                 460                 


Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser 
465                 470                 475                 480 


Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys 
                485                 490                 495     


Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp 
            500                 505                 510         


Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe 
        515                 520                 525             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    530                 535                 540                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
545                 550                 555                 560 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                565                 570                 575     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            580                 585                 590         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        595                 600                 605             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    610                 615                 620                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
625                 630                 635                 640 


Pro Lys Ser Cys Val His His His His His His Gly Leu Asn Asp Ile 
                645                 650                 655     


Phe Glu Ala Gln Lys Ile Glu Trp His 
            660                 665 


<210>  112
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of hBAFab(human Kappa) Protein of Soluble single chain 
       HLA-A*23:01:01: molecule with PYLFWLAAI peptide and an anti MSLN 
       ScFv with Tags. T cell Engaging domain and Fab light Chain

<400>  112

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  113
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ala Pro Leu Leu Pro Ile Arg Thr Leu Pro Leu Ile Leu Ile Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ser Pro Gly Ala Ala Asp Phe Asn Ile Ser Ser Leu 
            20                  25                  30          


Ser Gly Leu Leu Ser Pro Ala Leu Thr Glu Ser Leu Leu Val Ala Leu 
        35                  40                  45              


Pro Pro Cys His Leu Thr Gly Gly Asn Ala Thr Leu Met Val Arg Arg 
    50                  55                  60                  


Ala Asn Asp Ser Lys Val Val Thr Ser Ser Phe Val Val Pro Pro Cys 
65                  70                  75                  80  


Arg Gly Arg Arg Glu Leu Val Ser Val Val Asp Ser Gly Ala Gly Phe 
                85                  90                  95      


Thr Val Thr Arg Leu Ser Ala Tyr Gln Val Thr Asn Leu Val Pro Gly 
            100                 105                 110         


Thr Lys Phe Tyr Ile Ser Tyr Leu Val Lys Lys Gly Thr Ala Thr Glu 
        115                 120                 125             


Ser Ser Arg Glu Ile Pro Met Ser Thr Leu Pro Arg Arg Asn Met Glu 
    130                 135                 140                 


Ser Ile Gly Leu Gly Met Ala Arg Thr Gly Gly Met Val Val Ile Thr 
145                 150                 155                 160 


Val Leu Leu Ser Val Ala Met Phe Leu Leu Val Leu Gly Phe Ile Ile 
                165                 170                 175     


Ala Leu Ala Leu Gly Ser Arg Lys 
            180                 


<210>  114
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Ser Ala Ala Ala Ala Glu Ala Glu Lys Gly Ser Pro Val Val 
1               5                   10                  15      


Val Gly Leu Leu Val Val Gly Asn Ile Ile Ile Leu Leu Ser Gly Leu 
            20                  25                  30          


Ser Leu Phe Ala Glu Thr Ile Trp Val Thr Ala Asp Gln Tyr Arg Val 
        35                  40                  45              


Tyr Pro Leu Met Gly Val Ser Gly Lys Asp Asp Val Phe Ala Gly Ala 
    50                  55                  60                  


Trp Ile Ala Ile Phe Cys Gly Phe Ser Phe Phe Met Val Ala Ser Phe 
65                  70                  75                  80  


Gly Val Gly Ala Ala Leu Cys Arg Arg Arg Ser Met Val Leu Thr Tyr 
                85                  90                  95      


Leu Val Leu Met Leu Ile Val Tyr Ile Phe Glu Cys Ala Ser Cys Ile 
            100                 105                 110         


Thr Ser Tyr Thr His Arg Asp Tyr Met Val Ser Asn Pro Ser Leu Ile 
        115                 120                 125             


Thr Lys Gln Met Leu Thr Phe Tyr Ser Ala Asp Thr Asp Gln Gly Gln 
    130                 135                 140                 


Glu Leu Thr Arg Leu Trp Asp Arg Val Met Ile Glu Gln Glu Cys Cys 
145                 150                 155                 160 


Gly Thr Ser Gly Pro Met Asp Trp Val Asn Phe Thr Ser Ala Phe Arg 
                165                 170                 175     


Ala Ala Thr Pro Glu Val Val Phe Pro Trp Pro Pro Leu Cys Cys Arg 
            180                 185                 190         


Arg Thr Gly Asn Phe Ile Pro Leu Asn Glu Glu Gly Cys Arg Leu Gly 
        195                 200                 205             


His Met Asp Tyr Leu Phe Thr Lys Ala Gly Val Gln Trp His Asn Leu 
    210                 215                 220                 


Ser Ser Leu Gln Arg Leu Pro Pro Gly Phe Lys Gly Phe Ser His Leu 
225                 230                 235                 240 


Ser Phe Gln Ser Ser Trp Asp Tyr Arg Ala Ala Ser Asn Thr Ser Ala 
                245                 250                 255     


Thr Pro Ser Thr Ala Thr Arg Gly Val Ser Arg Gly Leu Gly Leu Pro 
            260                 265                 270         


Ser 
    


<210>  115
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ala Ser Ala Ala Ala Ala Glu Ala Glu Lys Gly Ser Pro Val Val 
1               5                   10                  15      


Val Gly Leu Leu Val Val Gly Asn Ile Ile Ile Leu Leu Ser Gly Leu 
            20                  25                  30          


Ser Leu Phe Ala Glu Thr Ile Trp Val Thr Ala Asp Gln Tyr Arg Val 
        35                  40                  45              


Tyr Pro Leu Met Gly Val Ser Gly Lys Asp Asp Val Phe Ala Gly Ala 
    50                  55                  60                  


Trp Ile Ala Ile Phe Cys Gly Phe Ser Phe Phe Met Val Ala Ser Phe 
65                  70                  75                  80  


Gly Val Gly Ala Ala Leu Cys Arg Arg Arg Ser Met Val Leu Thr Tyr 
                85                  90                  95      


Leu Val Leu Met Leu Ile Val Tyr Ile Phe Glu Cys Ala Ser Cys Ile 
            100                 105                 110         


Thr Ser Tyr Thr His Arg Asp Tyr Met Val Ser Asn Pro Ser Leu Ile 
        115                 120                 125             


Thr Lys Gln Met Leu Thr Phe Tyr Ser Ala Asp Thr Asp Gln Gly Gln 
    130                 135                 140                 


Glu Leu Thr Arg Leu Trp Asp Arg Val Met Ile Glu Gln Glu Cys Cys 
145                 150                 155                 160 


Gly Thr Ser Gly Pro Met Asp Trp Val Asn Phe Thr Ser Ala Phe Arg 
                165                 170                 175     


Ala Ala Thr Pro Glu Val Val Phe Pro Trp Pro Pro Leu Cys Cys Arg 
            180                 185                 190         


Arg Thr Gly Asn Phe Ile Pro Leu Asn Glu Glu Gly Cys Arg Leu Gly 
        195                 200                 205             


His Met Asp Tyr Leu Phe Thr Lys Gly Cys Phe Glu His Ile Gly His 
    210                 215                 220                 


Ala Ile Asp Ser Tyr Thr Trp Gly Ile Ser Trp Phe Gly Phe Ala Ile 
225                 230                 235                 240 


Leu Met Trp Thr Leu Pro Val Met Leu Ile Ala Met Tyr Phe Tyr Thr 
                245                 250                 255     


Met Leu 
        


<210>  116
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Lys Gln Ser Phe Pro Leu Phe Leu Thr Pro Ser Pro Trp Lys Thr 
1               5                   10                  15      


Thr Val Leu Leu Leu Tyr Met Arg Ile Cys Tyr Val Pro Ser Tyr Lys 
            20                  25                  30          


Trp Asn Tyr Ser Ile Gly Leu Ile Tyr Leu Gly Ile Val Ser Glu Leu 
        35                  40                  45              


Pro His Met Val Gly Ile Gly Gln Asn Ser Ser Phe Asn Ser Trp Met 
    50                  55                  60                  


Glu Ser Gln Phe Leu His Pro Ser Met Glu Pro Gly Gln Trp Leu Pro 
65                  70                  75                  80  


Tyr Ile Thr Ile Phe Arg Phe Thr His Ile Ile Arg Cys Val Arg Ile 
                85                  90                  95      


Ser Phe Leu Phe Asn Ile Pro Trp Tyr Gly Tyr Pro His Phe Val Cys 
            100                 105                 110         


His Ser Ser Val Ser Gly His Leu Gly Tyr Phe Tyr Leu Leu Leu Leu 
        115                 120                 125             


Trp Leu Val Cys Cys Glu His Arg Cys Thr Asn Ile Cys Ser Arg Gln 
    130                 135                 140                 


Thr Ser Phe Lys Arg Leu Phe Leu Lys Lys Tyr Val Ser Tyr Asn Ile 
145                 150                 155                 160 


Phe Leu Leu Cys Val Glu Ser Asp Ile Ser Ile Asp Leu Glu Gly Tyr 
                165                 170                 175     


Gly Met Gly Cys Thr Asn Ile Cys Ser Arg Gln Thr Ser Phe Lys Arg 
            180                 185                 190         


Leu Phe Lys Arg Lys Tyr Arg Cys Leu Leu Asn Met Phe Leu Val Met 
        195                 200                 205             


Asn Val Glu Ser Gly Thr Asn Arg Tyr Met Glu Val Arg Arg Ala Trp 
    210                 215                 220                 


Arg Gly Ser Lys Trp Glu Asp Glu Glu Asn Trp Leu Gly Ile Asp Val 
225                 230                 235                 240 


Tyr Phe Glu Asp Arg 
                245 


<210>  117
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  118
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  119
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Val Leu Lys Val Ile 
    370                 375                 380                 


Phe Ala Val Ala Phe Cys Leu Ile Ser Ala Val Leu Met Val Leu Leu 
385                 390                 395                 400 


Phe Ile His Ile Arg Arg Gly Leu Cys Trp Gln Arg Glu Ser Tyr Gly 
                405                 410                 415     


Asn Ile 
        


<210>  120
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Asp Phe Ile Ala Thr Leu Gly Lys 
145                 150                 155                 160 


Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys Val 
                165                 170                 175     


Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro Ser 
            180                 185                 190         


Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu Leu 
        195                 200                 205             


Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser Arg 
    210                 215                 220                 


Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys Arg 
225                 230                 235                 240 


Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala His 
                245                 250                 255     


Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn Gly 
            260                 265                 270         


Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe Glu 
        275                 280                 285             


Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln His 
    290                 295                 300                 


Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro Leu 
305                 310                 315                 320 


Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp Ser 
                325                 330                 335     


Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser Thr 
            340                 345                 350         


Asp 
    


<210>  121
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
225                 230                 235                 240 


Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                245                 250                 255     


Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
            260                 265                 270         


Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
        275                 280                 285             


Leu Gln Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn 
    290                 295                 300                 


Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val 
305                 310                 315                 320 


Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 
                325                 330                 335 


<210>  122
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
225                 230                 235                 240 


Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                245                 250                 255     


Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
            260                 265                 270         


Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
        275                 280                 285             


Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 
    290                 295                 300                 


Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 
305                 310                 315                 320 


Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 
                325                 330                 335     


Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 
            340                 345                 350         


His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 
        355                 360                 365             


Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 
    370                 375                 380                 


Leu Gly Cys 
385         


<210>  123
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
145                 150                 155                 160 


Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
                165                 170                 175     


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
            180                 185                 190         


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
        195                 200                 205             


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
    210                 215                 220                 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
225                 230                 235                 240 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
                245                 250                 255     


Val Ala Ala Thr Ser Ala Asn Leu 
            260                 


<210>  124
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro 
                85                  90                  95      


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
            100                 105                 110         


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
        115                 120                 125             


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
    130                 135                 140                 


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
145                 150                 155                 160 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
                165                 170                 175     


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
            180                 185                 190         


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
        195                 200                 205             


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
    210                 215                 220                 


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
225                 230                 235                 240 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
                245                 250                 255 


<210>  125
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Ser Asp Val Pro Phe Pro Phe 
                85                  90                  95      


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
            100                 105                 110         


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
        115                 120                 125             


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
    130                 135                 140                 


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
145                 150                 155                 160 


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
                165                 170                 175     


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
            180                 185                 190         


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        195                 200             


<210>  126
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln 
65                  70                  75                  80  


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                85                  90                  95      


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            100                 105                 110         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        115                 120                 125             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    130                 135                 140                 


Ala Thr Ser Ala Asn Leu 
145                 150 


<210>  127
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                85                  90                  95      


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            100                 105                 110         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        115                 120                 125             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    130                 135                 140                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
145                 150                 155                 


<210>  128
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Trp Gly Trp Gly Ala Arg Leu 
                85                  90                  95      


Gly His Arg Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His 
            100                 105                 110         


Cys Leu Ser His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu 
        115                 120                 125             


Arg Ala Ala Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu 
    130                 135                 140                 


Arg Val Pro His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 
145                 150                 155             


<210>  129
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His 
                165                 170                 175     


Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu 
            180                 185                 190         


Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys 
        195                 200                 205             


Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr 
    210                 215                 220                 


Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser 
225                 230                 235                 240 


Thr Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu 
                245                 250                 255     


Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu 
            260                 265                 270         


Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu 
        275                 280                 285             


Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly 
    290                 295                 300                 


Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val 
305                 310                 315                 320 


Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
                325                 330                 335     


Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
            340                 345                 350         


Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe 
        355                 360                 365             


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
    370                 375                 380                 


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
385                 390                 395                 400 


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
                405                 410                 415     


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
            420                 425                 430         


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
        435                 440                 445             


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
    450                 455                 460                 


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
465                 470                 475 


<210>  130
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser 
    50                  55                  60                  


Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser 
65                  70                  75                  80  


Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala 
                85                  90                  95      


Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val 
            100                 105                 110         


Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr 
        115                 120                 125             


Ser Ala Pro Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
    130                 135                 140                 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
145                 150                 155                 160 


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg Pro Ala 
                165                 170                 175     


Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala Ser Gly 
            180                 185                 190         


Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala 
        195                 200                 205             


Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro 
    210                 215                 220                 


Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys 
225                 230                 235                 240 


Thr Asp Ala Ser Ser Thr His His Ser Thr Val Pro Pro Leu Thr Ser 
                245                 250                 255     


Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe 
            260                 265                 270         


Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu 
        275                 280                 285             


Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu 
    290                 295                 300                 


Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn 
305                 310                 315                 320 


Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe 
                325                 330                 335     


Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln 
            340                 345                 350         


Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val 
        355                 360                 365             


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    370                 375                 380                 


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
385                 390                 395                 400 


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
                405                 410                 415     


Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 
            420                 425                 430         


His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 
        435                 440                 445             


Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 
    450                 455                 460                 


Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 
465                 470                 475                 480 


Ser Ala Asn Leu 
                


<210>  131
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly 
            100                 105                 110         


Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val 
        115                 120                 125             


Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val 
    130                 135                 140                 


Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn 
145                 150                 155                 160 


Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser 
                165                 170                 175     


Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val 
            180                 185                 190         


Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu 
        195                 200                 205             


Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe 
    210                 215                 220                 


Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His 
225                 230                 235                 240 


Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr 
                245                 250                 255     


Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn 
            260                 265                 270         


Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        275                 280         


<210>  132
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Trp Gly Trp Gly Ala Arg Leu Gly His Arg 
145                 150                 155                 160 


Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His Cys Leu Ser 
                165                 170                 175     


His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala 
            180                 185                 190         


Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro 
        195                 200                 205             


His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 
    210                 215                 


<210>  133
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr 
    50                  55                  60                  


Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly 
65                  70                  75                  80  


Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
                85                  90                  95      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            100                 105                 110         


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        115                 120                 125             


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile 
    130                 135                 140                 


Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr 
145                 150                 155                 160 


Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 
                165                 170                 175     


Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 
            180                 185                 190         


Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 
        195                 200                 205             


Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 
    210                 215                 220                 


Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
225                 230                 235             


<210>  134
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser 
            20                  25                  30          


Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr Lys Gln Gly Gly Phe 
        35                  40                  45              


Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln 
    50                  55                  60                  


Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu 
65                  70                  75                  80  


Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu 
                85                  90                  95      


Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala 
            100                 105                 110         


Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu 
        115                 120                 125             


Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala 
    130                 135                 140                 


Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro 
145                 150                 155                 160 


Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr 
                165                 170                 175     


His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu 
            180                 185                 190         


Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro 
        195                 200                 205             


Ala Val Ala Ala Thr Ser Ala Asn Leu 
    210                 215         


<210>  135
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Leu 
    50                  55                  60                  


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
65                  70                  75                  80  


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
                85                  90                  95      


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
            100                 105                 110         


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
        115                 120                 125             


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
    130                 135                 140                 


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
145                 150                 155                 160 


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
                165                 170                 175     


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
            180                 185                 190         


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
        195                 200                 205             


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
    210                 215                 220                 


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
225                 230                 235                 240 


Leu 
    


<210>  136
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Trp Pro 
65                  70                  75                  80  


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
                85                  90                  95      


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
            100                 105                 110         


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
        115                 120                 125             


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
    130                 135                 140                 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
145                 150                 155                 160 


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                165                 170                 175     


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            180                 185                 190         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        195                 200                 205             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    210                 215                 220                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
225                 230                 235                 


<210>  137
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Gly Cys 
145                 150                 155                 160 


Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala Gly His Leu Ser Ser 
                165                 170                 175     


Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro His Leu Pro His Pro 
            180                 185                 190         


Trp Ala Leu Cys Ala Pro 
        195             


<210>  138
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Trp Pro Gly Ser Val Val Val Gln Leu Thr Leu 
65                  70                  75                  80  


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
                85                  90                  95      


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser 
            100                 105                 110         


Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly 
        115                 120                 125             


Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 
    130                 135                 140                 


Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 
145                 150                 155                 160 


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                165                 170                 175     


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            180                 185                 190         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        195                 200                 205             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    210                 215                 220                 


Ala Thr Ser Ala Asn Leu 
225                 230 


<210>  139
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala 
                85                  90                  95      


Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu 
            100                 105                 110         


Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu 
        115                 120                 125             


Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro 
    130                 135                 140                 


Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg 
145                 150                 155                 160 


Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser 
                165                 170                 175     


Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
            180                 185                 


<210>  140
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Cys Phe 
65                  70                  75                  80  


Cys Arg Phe Ile Asn Lys Gly Val Phe Trp Ala Ser Pro Ile Leu Ser 
                85                  90                  95      


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
            100                 105                 110         


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
        115                 120                 125             


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
    130                 135                 140                 


Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 
145                 150                 155                 160 


His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 
                165                 170                 175     


Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 
            180                 185                 190         


Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 
        195                 200                 205             


Ser Ala Asn Leu 
    210         


<210>  141
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn 
            100                 105                 110         


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
        115                 120                 125             


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
    130                 135                 140                 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
145                 150                 155                 160 


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
                165                 170                 175     


Leu 
    


<210>  142
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  143
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Gly Ser Gln Val Trp Gly Gly 
            20                  25                  30          


Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp 
        35                  40                  45              


Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser Gln Lys Arg Ser Phe Val 
    50                  55                  60                  


Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro 
65                  70                  75                  80  


Val Ser Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His 
                85                  90                  95      


Thr Met Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val 
            100                 105                 110         


Pro Leu Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro 
        115                 120                 125             


Phe Ser Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys 
    130                 135                 140                 


His Phe Leu Arg Asn Gln Pro Leu Thr Phe Ala Leu Gln Leu His Asp 
145                 150                 155                 160 


Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe 
                165                 170                 175     


Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg Ala Leu Val Val Thr His 
            180                 185                 190         


Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala Gln Val Val Leu Gln Ala 
        195                 200                 205             


Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr 
    210                 215                 220                 


Asp Gly His Arg Pro Thr Ala Glu Ala Pro Asn Thr Thr Ala Gly Gln 
225                 230                 235                 240 


Val Pro Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln Ala Pro Thr 
                245                 250                 255     


Ala Glu Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr Thr Glu Val 
            260                 265                 270         


Ile Ser Thr Ala Pro Val Gln Met Pro Thr Ala Glu Ser Thr Gly Met 
        275                 280                 285             


Thr Pro Glu Lys Val Pro Val Ser Glu Val Met Gly Thr Thr Leu Ala 
    290                 295                 300                 


Glu Met Ser Thr Pro Glu Ala Thr Gly Met Thr Pro Ala Glu Val Ser 
305                 310                 315                 320 


Ile Val Val Leu Ser Gly Thr Thr Ala Ala Gln Val Thr Thr Thr Glu 
                325                 330                 335     


Trp Val Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly 
            340                 345                 350         


Pro Asp Ala Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu 
        355                 360                 365             


Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln 
    370                 375                 380                 


Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr 
385                 390                 395                 400 


Leu Asp Ile Val Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val 
                405                 410                 415     


Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly 
            420                 425                 430         


Gly Leu Pro Lys Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln 
        435                 440                 445             


Pro Pro Ala Gln Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys 
    450                 455                 460                 


Gln Leu Val Leu His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys 
465                 470                 475                 480 


Leu Asn Val Ser Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr 
                485                 490                 495     


Gln Leu Ile Met Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu 
            500                 505                 510         


Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu 
        515                 520                 525             


Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu 
    530                 535                 540                 


Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser 
545                 550                 555                 560 


Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
                565                 570                 575 


<210>  144
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Val Pro Gly Ile Leu 
            580                 585                 590         


Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly 
        595                 600                 605             


Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr Arg 
    610                 615                 620                 


Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His Ser 
625                 630                 635                 640 


Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro Ile 
                645                 650                 655     


Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
            660                 665             


<210>  145
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  146
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  147
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                885                 890                 895     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            900                 905                 910         


Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val 
        915                 920                 925             


Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu 
    930                 935                 940                 


Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln 
945                 950                 955                 960 


Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr 
                965                 970                 975     


Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser 
            980                 985                 990         


Leu Gly Ala Lys Gly Ala Ala Gly  Pro Leu Pro Ser Glu  Ala Val Gln 
        995                 1000                 1005             


Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys Leu Thr  Arg His Arg 
    1010                 1015                 1020             


Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu Arg Thr  Ala Gln Thr 
    1025                 1030                 1035             


Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr Leu Thr  Ala Leu Glu 
    1040                 1045                 1050             


Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp Phe Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp 
    


<210>  148
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  149
<211>  353
<212>  PRT
<213>  Human T-lymphotropic virus 1

<400>  149

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Phe Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Gly Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Ala Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Ile 
    50                  55                  60                  


Gly Ser Ala Leu Gln Phe Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Ile Thr His 
                85                  90                  95      


Thr Thr Pro Asn Ile Pro Pro Ser Phe Leu Gln Ala Met Arg Lys Tyr 
            100                 105                 110         


Ser Pro Phe Arg Asn Gly Tyr Met Glu Pro Thr Leu Gly Gln His Leu 
        115                 120                 125             


Pro Thr Leu Ser Phe Pro Asp Pro Gly Leu Arg Pro Gln Asn Leu Tyr 
    130                 135                 140                 


Thr Leu Trp Gly Gly Ser Val Val Cys Met Tyr Leu Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Ile Thr Trp Pro Leu Leu Pro His Val Ile Phe Cys His Pro 
                165                 170                 175     


Gly Gln Leu Gly Ala Phe Leu Thr Asn Val Pro Tyr Lys Arg Ile Glu 
            180                 185                 190         


Lys Leu Leu Tyr Lys Ile Ser Leu Thr Thr Gly Ala Leu Ile Ile Leu 
        195                 200                 205             


Pro Glu Asp Cys Leu Pro Thr Thr Leu Phe Gln Pro Ala Arg Ala Pro 
    210                 215                 220                 


Val Thr Leu Thr Ala Trp Gln Asn Gly Leu Leu Pro Phe His Ser Thr 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Thr Asp Gly Thr Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Asp Gly Gln Pro Ser Leu Val Leu Gln 
            260                 265                 270         


Ser Ser Ser Phe Ile Phe His Lys Phe Gln Thr Lys Ala Tyr His Pro 
        275                 280                 285             


Ser Phe Leu Leu Ser His Gly Leu Ile Gln Tyr Ser Ser Phe His Asn 
    290                 295                 300                 


Leu His Leu Leu Phe Glu Glu Tyr Thr Asn Ile Pro Ile Ser Leu Leu 
305                 310                 315                 320 


Phe Asn Glu Lys Glu Ala Asp Asp Asn Asp His Glu Pro Gln Ile Ser 
                325                 330                 335     


Pro Gly Gly Leu Glu Pro Leu Ser Glu Lys His Phe Arg Glu Thr Glu 
            340                 345                 350         


Val 
    


<210>  150
<211>  345
<212>  PRT
<213>  Human T-lymphotropic virus 4

<400>  150

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Tyr Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Ala Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Pro Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Val 
    50                  55                  60                  


Gly Ser Pro Leu Gln Tyr Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Thr Thr Pro 
                85                  90                  95      


Val Thr Pro Lys Val Pro Pro Ser Phe Phe Gln Ser Val Arg Arg His 
            100                 105                 110         


Ser Pro Tyr Arg Asn Gly Cys Leu Glu Thr Thr Leu Gly Glu Gln Leu 
        115                 120                 125             


Pro Ser Leu Ala Phe Pro Glu Pro Gly Leu Arg Pro Gln Asn Val Tyr 
    130                 135                 140                 


Thr Ile Trp Gly Lys Thr Ile Val Cys Leu Tyr Ile Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Met Thr Trp Pro Leu Ile Pro His Val Ile Phe Cys Asn Pro 
                165                 170                 175     


Arg Gln Leu Gly Ala Phe Leu Ser Asn Val Pro Pro Lys Arg Leu Glu 
            180                 185                 190         


Glu Leu Leu Tyr Lys Leu Tyr Leu His Thr Gly Ala Ile Ile Ile Leu 
        195                 200                 205             


Pro Glu Asp Ala Leu Pro Thr Thr Leu Phe Gln Pro Val Arg Ala Pro 
    210                 215                 220                 


Cys Val Gln Thr Thr Trp Asn Thr Gly Leu Leu Pro Tyr Gln Pro Asn 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Asn Asp Gly Ser Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Ala Gly Gln Pro Ser Leu Val Val Gln 
            260                 265                 270         


Ser Ser Leu Leu Ile Phe Glu Arg Phe Gln Thr Lys Ala Tyr His Pro 
        275                 280                 285             


Ser Tyr Leu Leu Ser His Gln Leu Ile Gln Tyr Ser Ser Phe His His 
    290                 295                 300                 


Leu Tyr Leu Leu Phe Asp Glu Tyr Thr Thr Ile Pro Phe Ser Leu Leu 
305                 310                 315                 320 


Phe Lys Glu Lys Glu Gly Asp Asp Arg Asp Asn Asp Pro Leu Pro Gly 
                325                 330                 335     


Ala Thr Ala Ser Pro Gln Gly Gln Asn 
            340                 345 


<210>  151
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  152
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 
1               5                   10                  15      


Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 
            20                  25                  30          


Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 
        35                  40                  45              


Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 
    50                  55                  60                  


Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 
                85                  90                  95      


Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
            100                 105                 110         


Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 
        115                 120                 125             


Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 
    130                 135                 140                 


Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 
145                 150                 155                 160 


Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 
                165                 170                 175     


Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 
            180                 185                 190         


Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 
        195                 200                 205             


Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 
    210                 215                 220                 


Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
225                 230                 235                 240 


Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 
                245                 250                 255     


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 
            260                 265                 270         


Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 
        275                 280                 285             


Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 
    290                 295                 300                 


Glu Glu Glu Gly Val 
305                 


<210>  153
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  154
<211>  1225
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  155
<211>  1240
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Pro Arg Gly Ser Trp Lys Pro Gln Val Cys Thr Gly Thr Asp Met 
1               5                   10                  15      


Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg 
            20                  25                  30          


His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr 
        35                  40                  45              


Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu 
    50                  55                  60                  


Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro 
65                  70                  75                  80  


Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 
                85                  90                  95      


Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr 
            100                 105                 110         


Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg 
        115                 120                 125             


Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro 
    130                 135                 140                 


Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys 
145                 150                 155                 160 


Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala 
                165                 170                 175     


Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu 
            180                 185                 190         


Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly 
        195                 200                 205             


Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln 
    210                 215                 220                 


Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 
225                 230                 235                 240 


Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 
                245                 250                 255     


Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly 
            260                 265                 270         


Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr 
        275                 280                 285             


Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn 
    290                 295                 300                 


Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 
305                 310                 315                 320 


Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 
                325                 330                 335     


Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys 
            340                 345                 350         


Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 
        355                 360                 365             


Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val 
    370                 375                 380                 


Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 
385                 390                 395                 400 


Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile 
                405                 410                 415     


Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly 
            420                 425                 430         


Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 
        435                 440                 445             


Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr 
    450                 455                 460                 


Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 
465                 470                 475                 480 


Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys 
                485                 490                 495     


His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 
            500                 505                 510         


Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 
        515                 520                 525             


Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His 
    530                 535                 540                 


Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr 
545                 550                 555                 560 


Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys 
                565                 570                 575     


Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 
            580                 585                 590         


Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys 
        595                 600                 605             


Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp 
    610                 615                 620                 


Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile 
625                 630                 635                 640 


Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe 
                645                 650                 655     


Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665                 670         


Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser 
        675                 680                 685             


Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu 
    690                 695                 700                 


Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
705                 710                 715                 720 


Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala 
                725                 730                 735     


Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile 
            740                 745                 750         


Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser 
        755                 760                 765             


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln 
    770                 775                 780                 


Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly 
785                 790                 795                 800 


Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys 
                805                 810                 815     


Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala 
            820                 825                 830         


Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp 
        835                 840                 845             


Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala 
    850                 855                 860                 


Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
865                 870                 875                 880 


Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
                885                 890                 895     


Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro 
            900                 905                 910         


Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln 
        915                 920                 925             


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
    930                 935                 940                 


Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu 
945                 950                 955                 960 


Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn 
                965                 970                 975     


Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser 
            980                 985                 990         


Leu Leu Glu Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
        995                 1000                 1005             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1010                 1015                 1020             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1025                 1030                 1035             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1040                 1045                 1050             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1055                 1060                 1065             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1070                 1075                 1080             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1085                 1090                 1095             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1100                 1105                 1110             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1115                 1120                 1125             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1130                 1135                 1140             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1145                 1150                 1155             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1160                 1165                 1170             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1175                 1180                 1185             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1190                 1195                 1200             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1205                 1210                 1215             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1220                 1225                 1230             


Leu Gly  Leu Asp Val Pro Val  
    1235                 1240 


<210>  156
<211>  1055
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Asn Met  
    1055 


<210>  157
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser 
        595                 600             


<210>  158
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  159
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  160
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  161
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  162
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  163
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Gln Ser Gly Arg Gly Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala His Tyr Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Leu Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Cys Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys His Ser Thr Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg Leu Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Glu Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Pro  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Pro Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  164
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Phe 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr 
    690             


<210>  165
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 
            180                 185                 190         


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 
        195                 200                 205             


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
    210                 215                 220                 


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
225                 230                 235                 240 


Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 
                245                 250                 255     


Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
            260                 265                 270         


Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
        275                 280                 285             


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
    290                 295                 300                 


Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
305                 310                 315                 320 


Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
                325                 330                 335     


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
            340                 345                 350         


Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
        355                 360                 365             


Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
    370                 375                 380                 


Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
385                 390                 395                 400 


Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
                405                 410                 415     


Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 
            420                 425                 430         


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
        435                 440                 445             


Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


<210>  166
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Glu Gly Gly Arg Arg Ala Arg Val Val Ile Glu Ser Lys Arg Asn 
1               5                   10                  15      


Phe Phe Leu Gly Ala Phe Pro Thr Pro Phe Pro Ala Glu His Val Glu 
            20                  25                  30          


Leu Gly Arg Leu Gly Asp Ser Glu Thr Ala Met Val Pro Gly Lys Gly 
        35                  40                  45              


Gly Ala Asp Tyr Ile Leu Leu Pro Phe Lys Lys Met Asp Phe Ser Arg 
    50                  55                  60                  


Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser Glu Asp Leu Ala Ser 
65                  70                  75                  80  


Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln Arg Lys Gln Glu Pro 
                85                  90                  95      


Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu Gln Glu Lys Arg Met 
            100                 105                 110         


Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu Leu Leu Phe Arg Ile 
        115                 120                 125             


Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn Thr Arg Lys Glu Glu 
    130                 135                 140                 


Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala Gln Ile Ser Ala Tyr 
145                 150                 155                 160 


Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val Ser Arg Ser Glu Leu 
                165                 170                 175     


Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile Ser Lys Cys Lys Leu 
            180                 185                 190         


Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile Glu Met Glu Lys Arg 
        195                 200                 205             


Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu Lys Arg Val Cys Ala 
    210                 215                 220                 


Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn Asp Tyr Glu Glu Phe 
225                 230                 235                 240 


Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser Pro Asp Glu Phe Ser 
                245                 250                 255     


Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile Ser Asp Ser Pro Arg 
            260                 265                 270         


Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys Val Tyr Gln Met Lys 
        275                 280                 285             


Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala 
    290                 295                 300                 


Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn 
305                 310                 315                 320 


Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr Thr Phe Glu Glu Leu 
                325                 330                 335     


His Phe Glu Ile Lys Pro His Asp Asp Cys Thr Val Glu Gln Ile Tyr 
            340                 345                 350         


Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp Cys 
        355                 360                 365             


Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr Gly 
    370                 375                 380                 


Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Thr Ser Gln Phe Thr 
385                 390                 395                 400 


Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe Ile 
                405                 410                 415     


Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu Thr 
            420                 425                 430         


Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp Leu Ser Ser Pro Gln 
        435                 440                 445             


Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala Thr 
    450                 455                 460                 


Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Thr Trp Tyr 
465                 470                 475                 480 


Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly Asp 
                485                 490                 495     


Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr Glu Val Ser Asn Lys 
            500                 505                 510         


Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Thr Phe Thr 
        515                 520                 525             


Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    530                 535             


<210>  167
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Phe His Phe Cys Arg Met Ser Trp Ala Glu 
            100                 105                 110         


Ala Asn Ser Gln Cys Gln Thr Gln Ser Val Pro Phe Trp Arg Arg Val 
        115                 120                 125             


Asp His Leu Leu Ile Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
    130                 135                 140                 


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
145                 150                 155                 160 


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
                165                 170                 175     


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
            180                 185                 190         


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
        195                 200                 205             


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 
    210                 215                 220                 


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 
225                 230                 235                 240 


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
                245                 250                 255     


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
            260                 265                 270         


Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 
        275                 280                 285             


Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
    290                 295                 300                 


Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
305                 310                 315                 320 


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
                325                 330                 335     


Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
            340                 345                 350         


Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
        355                 360                 365             


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
    370                 375                 380                 


Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
385                 390                 395                 400 


Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
                405                 410                 415     


Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
            420                 425                 430         


Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
        435                 440                 445             


Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 
    450                 455                 460                 


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
465                 470                 475                 480 


Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
                485                 490                 495     


<210>  168
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 
            180                 185                 190         


Pro Asp Glu Phe Ser Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile 
        195                 200                 205             


Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys 
    210                 215                 220                 


Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn 
225                 230                 235                 240 


Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser 
                245                 250                 255     


Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr 
            260                 265                 270         


Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys Thr 
        275                 280                 285             


Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His 
    290                 295                 300                 


Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys 
305                 310                 315                 320 


Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu 
                325                 330                 335     


Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly 
        355                 360                 365             


Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp 
    370                 375                 380                 


Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu 
385                 390                 395                 400 


Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala 
                405                 410                 415     


Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg 
            420                 425                 430         


Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr 
        435                 440                 445             


Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro 
    450                 455                 460                 


Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
465                 470                 475                 


<210>  169
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 
            180                 185                 190         


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 
        195                 200                 205             


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
    210                 215                 220                 


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
225                 230                 235                 240 


Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 
                245                 250                 255     


Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
            260                 265                 270         


Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
        275                 280                 285             


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
    290                 295                 300                 


Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
305                 310                 315                 320 


Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
                325                 330                 335     


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
            340                 345                 350         


Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
        355                 360                 365             


Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
    370                 375                 380                 


Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
385                 390                 395                 400 


Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
                405                 410                 415     


Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 
            420                 425                 430         


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
        435                 440                 445             


Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


<210>  170
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 
            180                 185                 190         


Pro Asp Glu Phe Ser Asn Asp Phe Gly Gln Ser Leu Pro Asn Glu Lys 
        195                 200                 205             


Gln Thr Ser Gly Ile Leu Ser Asp His Gln Gln Ser Gln Phe Cys Lys 
    210                 215                 220                 


Ser Thr Gly Glu Ser Ala Gln Thr Ser Gln His 
225                 230                 235 


<210>  171
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210>  172
<211>  3312
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Gly Arg Ser Thr 
1               5                   10                  15      


Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu 
            20                  25                  30          


Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala 
        35                  40                  45              


Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys 
    50                  55                  60                  


Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val 
65                  70                  75                  80  


Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg 
                85                  90                  95      


Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu 
            100                 105                 110         


His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly 
        115                 120                 125             


Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg 
    130                 135                 140                 


Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu 
                165                 170                 175     


Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly 
            180                 185                 190         


Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu 
        195                 200                 205             


Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly 
    210                 215                 220                 


Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro 
                245                 250                 255     


Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala 
            260                 265                 270         


Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro 
        275                 280                 285             


Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala 
    290                 295                 300                 


Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn 
305                 310                 315                 320 


Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu 
                325                 330                 335     


Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro 
            340                 345                 350         


Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met 
        355                 360                 365             


Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu 
    370                 375                 380                 


Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr 
385                 390                 395                 400 


Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr 
                405                 410                 415     


Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val 
            420                 425                 430         


Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu 
        435                 440                 445             


Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro 
    450                 455                 460                 


Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser 
                485                 490                 495     


Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val 
            500                 505                 510         


Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr 
        515                 520                 525             


Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln 
    530                 535                 540                 


Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro 
545                 550                 555                 560 


His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala 
                565                 570                 575     


Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His 
            580                 585                 590         


Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu 
        595                 600                 605             


Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp 
    610                 615                 620                 


Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln 
625                 630                 635                 640 


Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe 
                645                 650                 655     


Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His 
            660                 665                 670         


Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr 
        675                 680                 685             


Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala 
    690                 695                 700                 


Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu 
705                 710                 715                 720 


His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu 
                725                 730                 735     


Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn 
            740                 745                 750         


Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp 
        755                 760                 765             


Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp 
    770                 775                 780                 


Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn 
785                 790                 795                 800 


Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala 
                805                 810                 815     


Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr 
            820                 825                 830         


Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile 
        835                 840                 845             


Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser 
    850                 855                 860                 


Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile 
865                 870                 875                 880 


Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu 
                885                 890                 895     


Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala 
            900                 905                 910         


Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr 
        915                 920                 925             


Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr 
    930                 935                 940                 


Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln 
945                 950                 955                 960 


Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro 
                965                 970                 975     


Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala 
            980                 985                 990         


Asn Gly Arg Val Gln Tyr Thr Phe  Gln Asn Gly Glu Asp  Gly Asp Gly 
        995                 1000                 1005             


Asp Phe  Thr Ile Glu Pro Thr  Ser Gly Ile Val Arg  Thr Val Arg 
    1010                 1015                 1020             


Arg Leu  Asp Arg Glu Ala Val  Ser Val Tyr Glu Leu  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Val  Asp Arg Gly Val Pro  Pro Leu Arg Thr Pro  Val Ser Ile 
    1040                 1045                 1050             


Gln Val  Met Val Gln Asp Val  Asn Asp Asn Ala Pro  Val Phe Pro 
    1055                 1060                 1065             


Ala Glu  Glu Phe Glu Val Arg  Val Lys Glu Asn Ser  Ile Val Gly 
    1070                 1075                 1080             


Ser Val  Val Ala Gln Ile Thr  Ala Val Asp Pro Asp  Glu Gly Pro 
    1085                 1090                 1095             


Asn Ala  His Ile Met Tyr Gln  Ile Val Glu Gly Asn  Ile Pro Glu 
    1100                 1105                 1110             


Leu Phe  Gln Met Asp Ile Phe  Ser Gly Glu Leu Thr  Ala Leu Ile 
    1115                 1120                 1125             


Asp Leu  Asp Tyr Glu Ala Arg  Gln Glu Tyr Val Ile  Val Val Gln 
    1130                 1135                 1140             


Ala Thr  Ser Ala Pro Leu Val  Ser Arg Ala Thr Val  His Val Arg 
    1145                 1150                 1155             


Leu Val  Asp Gln Asn Asp Asn  Ser Pro Val Leu Asn  Asn Phe Gln 
    1160                 1165                 1170             


Ile Leu  Phe Asn Asn Tyr Val  Ser Asn Arg Ser Asp  Thr Phe Pro 
    1175                 1180                 1185             


Ser Gly  Ile Ile Gly Arg Ile  Pro Ala Tyr Asp Pro  Asp Val Ser 
    1190                 1195                 1200             


Asp His  Leu Phe Tyr Ser Phe  Glu Arg Gly Asn Glu  Leu Gln Leu 
    1205                 1210                 1215             


Leu Val  Val Asn Gln Thr Ser  Gly Glu Leu Arg Leu  Ser Arg Lys 
    1220                 1225                 1230             


Leu Asp  Asn Asn Arg Pro Leu  Val Ala Ser Met Leu  Val Thr Val 
    1235                 1240                 1245             


Thr Asp  Gly Leu His Ser Val  Thr Ala Gln Cys Val  Leu Arg Val 
    1250                 1255                 1260             


Val Ile  Ile Thr Glu Glu Leu  Leu Ala Asn Ser Leu  Thr Val Arg 
    1265                 1270                 1275             


Leu Glu  Asn Met Trp Gln Glu  Arg Phe Leu Ser Pro  Leu Leu Gly 
    1280                 1285                 1290             


Arg Phe  Leu Glu Gly Val Ala  Ala Val Leu Ala Thr  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Phe Ile Phe Asn Ile  Gln Asn Asp Thr Asp  Val Gly Gly 
    1310                 1315                 1320             


Thr Val  Leu Asn Val Ser Phe  Ser Ala Leu Ala Pro  Arg Gly Ala 
    1325                 1330                 1335             


Gly Ala  Gly Ala Ala Gly Pro  Trp Phe Ser Ser Glu  Glu Leu Gln 
    1340                 1345                 1350             


Glu Gln  Leu Tyr Val Arg Arg  Ala Ala Leu Ala Ala  Arg Ser Leu 
    1355                 1360                 1365             


Leu Asp  Val Leu Pro Phe Asp  Asp Asn Val Cys Leu  Arg Glu Pro 
    1370                 1375                 1380             


Cys Glu  Asn Tyr Met Lys Cys  Val Ser Val Leu Arg  Phe Asp Ser 
    1385                 1390                 1395             


Ser Ala  Pro Phe Leu Ala Ser  Ala Ser Thr Leu Phe  Arg Pro Ile 
    1400                 1405                 1410             


Gln Pro  Ile Ala Gly Leu Arg  Cys Arg Cys Pro Pro  Gly Phe Thr 
    1415                 1420                 1425             


Gly Asp  Phe Cys Glu Thr Glu  Leu Asp Leu Cys Tyr  Ser Asn Pro 
    1430                 1435                 1440             


Cys Arg  Asn Gly Gly Ala Cys  Ala Arg Arg Glu Gly  Gly Tyr Thr 
    1445                 1450                 1455             


Cys Val  Cys Arg Pro Arg Phe  Thr Gly Glu Asp Cys  Glu Leu Asp 
    1460                 1465                 1470             


Thr Glu  Ala Gly Arg Cys Val  Pro Gly Val Cys Arg  Asn Gly Gly 
    1475                 1480                 1485             


Thr Cys  Thr Asp Ala Pro Asn  Gly Gly Phe Arg Cys  Gln Cys Pro 
    1490                 1495                 1500             


Ala Gly  Gly Ala Phe Glu Gly  Pro Arg Cys Glu Val  Ala Ala Arg 
    1505                 1510                 1515             


Ser Phe  Pro Pro Ser Ser Phe  Val Met Phe Arg Gly  Leu Arg Gln 
    1520                 1525                 1530             


Arg Phe  His Leu Thr Leu Ser  Leu Ser Phe Ala Thr  Val Gln Gln 
    1535                 1540                 1545             


Ser Gly  Leu Leu Phe Tyr Asn  Gly Arg Leu Asn Glu  Lys His Asp 
    1550                 1555                 1560             


Phe Leu  Ala Leu Glu Leu Val  Ala Gly Gln Val Arg  Leu Thr Tyr 
    1565                 1570                 1575             


Ser Thr  Gly Glu Ser Asn Thr  Val Val Ser Pro Thr  Val Pro Gly 
    1580                 1585                 1590             


Gly Leu  Ser Asp Gly Gln Trp  His Thr Val His Leu  Arg Tyr Tyr 
    1595                 1600                 1605             


Asn Lys  Pro Arg Thr Asp Ala  Leu Gly Gly Ala Gln  Gly Pro Ser 
    1610                 1615                 1620             


Lys Asp  Lys Val Ala Val Leu  Ser Val Asp Asp Cys  Asp Val Ala 
    1625                 1630                 1635             


Val Ala  Leu Gln Phe Gly Ala  Glu Ile Gly Asn Tyr  Ser Cys Ala 
    1640                 1645                 1650             


Ala Ala  Gly Val Gln Thr Ser  Ser Lys Lys Ser Leu  Asp Leu Thr 
    1655                 1660                 1665             


Gly Pro  Leu Leu Leu Gly Gly  Val Pro Asn Leu Pro  Glu Asn Phe 
    1670                 1675                 1680             


Pro Val  Ser His Lys Asp Phe  Ile Gly Cys Met Arg  Asp Leu His 
    1685                 1690                 1695             


Ile Asp  Gly Arg Arg Val Asp  Met Ala Ala Phe Val  Ala Asn Asn 
    1700                 1705                 1710             


Gly Thr  Met Ala Gly Cys Gln  Ala Lys Leu His Phe  Cys Asp Ser 
    1715                 1720                 1725             


Gly Pro  Cys Lys Asn Ser Gly  Phe Cys Ser Glu Arg  Trp Gly Ser 
    1730                 1735                 1740             


Phe Ser  Cys Asp Cys Pro Val  Gly Phe Gly Gly Lys  Asp Cys Gln 
    1745                 1750                 1755             


Leu Thr  Met Ala His Pro His  His Phe Arg Gly Asn  Gly Thr Leu 
    1760                 1765                 1770             


Ser Trp  Asn Phe Gly Ser Asp  Met Ala Val Ser Val  Pro Trp Tyr 
    1775                 1780                 1785             


Leu Gly  Leu Ala Phe Arg Thr  Arg Ala Thr Gln Gly  Val Leu Met 
    1790                 1795                 1800             


Gln Val  Gln Ala Gly Pro His  Ser Thr Leu Leu Cys  Gln Leu Asp 
    1805                 1810                 1815             


Arg Gly  Leu Leu Ser Val Thr  Val Thr Arg Gly Ser  Gly Arg Ala 
    1820                 1825                 1830             


Ser His  Leu Leu Leu Asp Gln  Val Thr Val Ser Asp  Gly Arg Trp 
    1835                 1840                 1845             


His Asp  Leu Arg Leu Glu Leu  Gln Glu Glu Pro Gly  Gly Arg Arg 
    1850                 1855                 1860             


Gly His  His Val Leu Met Val  Ser Leu Asp Phe Ser  Leu Phe Gln 
    1865                 1870                 1875             


Asp Thr  Met Ala Val Gly Ser  Glu Leu Gln Gly Leu  Lys Val Lys 
    1880                 1885                 1890             


Gln Leu  His Val Gly Gly Leu  Pro Pro Gly Ser Ala  Glu Glu Ala 
    1895                 1900                 1905             


Pro Gln  Gly Leu Val Gly Cys  Ile Gln Gly Val Trp  Leu Gly Ser 
    1910                 1915                 1920             


Thr Pro  Ser Gly Ser Pro Ala  Leu Leu Pro Pro Ser  His Arg Val 
    1925                 1930                 1935             


Asn Ala  Glu Pro Gly Cys Val  Val Thr Asn Ala Cys  Ala Ser Gly 
    1940                 1945                 1950             


Pro Cys  Pro Pro His Ala Asp  Cys Arg Asp Leu Trp  Gln Thr Phe 
    1955                 1960                 1965             


Ser Cys  Thr Cys Gln Pro Gly  Tyr Tyr Gly Pro Gly  Cys Val Asp 
    1970                 1975                 1980             


Ala Cys  Leu Leu Asn Pro Cys  Gln Asn Gln Gly Ser  Cys Arg His 
    1985                 1990                 1995             


Leu Pro  Gly Ala Pro His Gly  Tyr Thr Cys Asp Cys  Val Gly Gly 
    2000                 2005                 2010             


Tyr Phe  Gly His His Cys Glu  His Arg Met Asp Gln  Gln Cys Pro 
    2015                 2020                 2025             


Arg Gly  Trp Trp Gly Ser Pro  Thr Cys Gly Pro Cys  Asn Cys Asp 
    2030                 2035                 2040             


Val His  Lys Gly Phe Asp Pro  Asn Cys Asn Lys Thr  Asn Gly Gln 
    2045                 2050                 2055             


Cys His  Cys Lys Glu Phe His  Tyr Arg Pro Arg Gly  Ser Asp Ser 
    2060                 2065                 2070             


Cys Leu  Pro Cys Asp Cys Tyr  Pro Val Gly Ser Thr  Ser Arg Ser 
    2075                 2080                 2085             


Cys Ala  Pro His Ser Gly Gln  Cys Pro Cys Arg Pro  Gly Ala Leu 
    2090                 2095                 2100             


Gly Arg  Gln Cys Asn Ser Cys  Asp Ser Pro Phe Ala  Glu Val Thr 
    2105                 2110                 2115             


Ala Ser  Gly Cys Arg Val Leu  Tyr Asp Ala Cys Pro  Lys Ser Leu 
    2120                 2125                 2130             


Arg Ser  Gly Val Trp Trp Pro  Gln Thr Lys Phe Gly  Val Leu Ala 
    2135                 2140                 2145             


Thr Val  Pro Cys Pro Arg Gly  Ala Leu Gly Ala Ala  Val Arg Leu 
    2150                 2155                 2160             


Cys Asp  Glu Ala Gln Gly Trp  Leu Glu Pro Asp Leu  Phe Asn Cys 
    2165                 2170                 2175             


Thr Ser  Pro Ala Phe Arg Glu  Leu Ser Leu Leu Leu  Asp Gly Leu 
    2180                 2185                 2190             


Glu Leu  Asn Lys Thr Ala Leu  Asp Thr Met Glu Ala  Lys Lys Leu 
    2195                 2200                 2205             


Ala Gln  Arg Leu Arg Glu Val  Thr Gly His Thr Asp  His Tyr Phe 
    2210                 2215                 2220             


Ser Gln  Asp Val Arg Val Thr  Ala Arg Leu Leu Ala  His Leu Leu 
    2225                 2230                 2235             


Ala Phe  Glu Ser His Gln Gln  Gly Phe Gly Leu Thr  Ala Thr Gln 
    2240                 2245                 2250             


Asp Ala  His Phe Asn Glu Asn  Leu Leu Trp Ala Gly  Ser Ala Leu 
    2255                 2260                 2265             


Leu Ala  Pro Glu Thr Gly Asp  Leu Trp Ala Ala Leu  Gly Gln Arg 
    2270                 2275                 2280             


Ala Pro  Gly Gly Ser Pro Gly  Ser Ala Gly Leu Val  Arg His Leu 
    2285                 2290                 2295             


Glu Glu  Tyr Ala Ala Thr Leu  Ala Arg Asn Met Glu  Leu Thr Tyr 
    2300                 2305                 2310             


Leu Asn  Pro Met Gly Leu Val  Thr Pro Asn Ile Met  Leu Ser Ile 
    2315                 2320                 2325             


Asp Arg  Met Glu His Pro Ser  Ser Pro Arg Gly Ala  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Arg  Tyr His Ser Asn Leu  Phe Arg Gly Gln Asp  Ala Trp Asp 
    2345                 2350                 2355             


Pro His  Thr His Val Leu Leu  Pro Ser Gln Ser Pro  Arg Pro Ser 
    2360                 2365                 2370             


Pro Ser  Glu Val Leu Pro Thr  Ser Ser Ser Ile Glu  Asn Ser Thr 
    2375                 2380                 2385             


Thr Ser  Ser Val Val Pro Pro  Pro Ala Pro Pro Glu  Pro Glu Pro 
    2390                 2395                 2400             


Gly Ile  Ser Ile Ile Ile Leu  Leu Val Tyr Arg Thr  Leu Gly Gly 
    2405                 2410                 2415             


Leu Leu  Pro Ala Gln Phe Gln  Ala Glu Arg Arg Gly  Ala Arg Leu 
    2420                 2425                 2430             


Pro Gln  Asn Pro Val Met Asn  Ser Pro Val Val Ser  Val Ala Val 
    2435                 2440                 2445             


Phe His  Gly Arg Asn Phe Leu  Arg Gly Ile Leu Glu  Ser Pro Ile 
    2450                 2455                 2460             


Ser Leu  Glu Phe Arg Leu Leu  Gln Thr Ala Asn Arg  Ser Lys Ala 
    2465                 2470                 2475             


Ile Cys  Val Gln Trp Asp Pro  Pro Gly Leu Ala Glu  Gln His Gly 
    2480                 2485                 2490             


Val Trp  Thr Ala Arg Asp Cys  Glu Leu Val His Arg  Asn Gly Ser 
    2495                 2500                 2505             


His Ala  Arg Cys Arg Cys Ser  Arg Thr Gly Thr Phe  Gly Val Leu 
    2510                 2515                 2520             


Met Asp  Ala Ser Pro Arg Glu  Arg Leu Glu Gly Asp  Leu Glu Leu 
    2525                 2530                 2535             


Leu Ala  Val Phe Thr His Val  Val Val Ala Val Ser  Val Ala Ala 
    2540                 2545                 2550             


Leu Val  Leu Thr Ala Ala Ile  Leu Leu Ser Leu Arg  Ser Leu Lys 
    2555                 2560                 2565             


Ser Asn  Val Arg Gly Ile His  Ala Asn Val Ala Ala  Ala Leu Gly 
    2570                 2575                 2580             


Val Ala  Glu Leu Leu Phe Leu  Leu Gly Ile His Arg  Thr His Asn 
    2585                 2590                 2595             


Gln Leu  Val Cys Thr Ala Val  Ala Ile Leu Leu His  Tyr Phe Phe 
    2600                 2605                 2610             


Leu Ser  Thr Phe Ala Trp Leu  Phe Val Gln Gly Leu  His Leu Tyr 
    2615                 2620                 2625             


Arg Met  Gln Val Glu Pro Arg  Asn Val Asp Arg Gly  Ala Met Arg 
    2630                 2635                 2640             


Phe Tyr  His Ala Leu Gly Trp  Gly Val Pro Ala Val  Leu Leu Gly 
    2645                 2650                 2655             


Leu Ala  Val Gly Leu Asp Pro  Glu Gly Tyr Gly Asn  Pro Asp Phe 
    2660                 2665                 2670             


Cys Trp  Ile Ser Val His Glu  Pro Leu Ile Trp Ser  Phe Ala Gly 
    2675                 2680                 2685             


Pro Val  Val Leu Val Ile Val  Met Asn Gly Thr Met  Phe Leu Leu 
    2690                 2695                 2700             


Ala Ala  Arg Thr Ser Cys Ser  Thr Gly Gln Arg Glu  Ala Lys Lys 
    2705                 2710                 2715             


Thr Ser  Ala Leu Thr Leu Arg  Ser Ser Phe Leu Leu  Leu Leu Leu 
    2720                 2725                 2730             


Val Ser  Ala Ser Trp Leu Phe  Gly Leu Leu Ala Val  Asn His Ser 
    2735                 2740                 2745             


Ile Leu  Ala Phe His Tyr Leu  His Ala Gly Leu Cys  Gly Leu Gln 
    2750                 2755                 2760             


Gly Leu  Ala Val Leu Leu Leu  Phe Cys Val Leu Asn  Ala Asp Ala 
    2765                 2770                 2775             


Arg Ala  Ala Trp Met Pro Ala  Cys Leu Gly Arg Lys  Ala Ala Pro 
    2780                 2785                 2790             


Glu Glu  Ala Arg Pro Ala Pro  Gly Leu Gly Pro Gly  Ala Tyr Asn 
    2795                 2800                 2805             


Asn Thr  Ala Leu Phe Glu Glu  Ser Gly Leu Ile Arg  Ile Thr Leu 
    2810                 2815                 2820             


Gly Ala  Ser Thr Val Ser Ser  Val Ser Ser Ala Arg  Ser Gly Arg 
    2825                 2830                 2835             


Thr Gln  Asp Gln Asp Ser Gln  Arg Gly Arg Ser Tyr  Leu Arg Asp 
    2840                 2845                 2850             


Asn Val  Leu Val Arg His Gly  Ser Ala Ala Asp His  Thr Asp His 
    2855                 2860                 2865             


Ser Leu  Gln Ala His Ala Gly  Pro Thr Asp Leu Asp  Val Ala Met 
    2870                 2875                 2880             


Phe His  Arg Asp Ala Gly Ala  Asp Ser Asp Ser Asp  Ser Asp Leu 
    2885                 2890                 2895             


Ser Leu  Glu Glu Glu Arg Ser  Leu Ser Ile Pro Ser  Ser Glu Ser 
    2900                 2905                 2910             


Glu Asp  Asn Gly Arg Thr Arg  Gly Arg Phe Gln Arg  Pro Leu Cys 
    2915                 2920                 2925             


Arg Ala  Ala Gln Ser Glu Arg  Leu Leu Thr His Pro  Lys Asp Val 
    2930                 2935                 2940             


Asp Gly  Asn Asp Leu Leu Ser  Tyr Trp Pro Ala Leu  Gly Glu Cys 
    2945                 2950                 2955             


Glu Ala  Ala Pro Cys Ala Leu  Gln Thr Trp Gly Ser  Glu Arg Arg 
    2960                 2965                 2970             


Leu Gly  Leu Asp Thr Ser Lys  Asp Ala Ala Asn Asn  Asn Gln Pro 
    2975                 2980                 2985             


Asp Pro  Ala Leu Thr Ser Gly  Asp Glu Thr Ser Leu  Gly Arg Ala 
    2990                 2995                 3000             


Gln Arg  Gln Arg Lys Gly Ile  Leu Lys Asn Arg Leu  Gln Tyr Pro 
    3005                 3010                 3015             


Leu Val  Pro Gln Thr Arg Gly  Ala Pro Glu Leu Ser  Trp Cys Arg 
    3020                 3025                 3030             


Ala Ala  Thr Leu Gly His Arg  Ala Val Pro Ala Ala  Ser Tyr Gly 
    3035                 3040                 3045             


Arg Ile  Tyr Ala Gly Gly Gly  Thr Gly Ser Leu Ser  Gln Pro Ala 
    3050                 3055                 3060             


Ser Arg  Tyr Ser Ser Arg Glu  Gln Leu Asp Leu Leu  Leu Arg Arg 
    3065                 3070                 3075             


Gln Leu  Ser Arg Glu Arg Leu  Glu Glu Ala Pro Ala  Pro Val Leu 
    3080                 3085                 3090             


Arg Pro  Leu Ser Arg Pro Gly  Ser Gln Glu Cys Met  Asp Ala Ala 
    3095                 3100                 3105             


Pro Gly  Arg Leu Glu Pro Lys  Asp Arg Gly Ser Thr  Leu Pro Arg 
    3110                 3115                 3120             


Arg Gln  Pro Pro Arg Asp Tyr  Pro Gly Ala Met Ala  Gly Arg Phe 
    3125                 3130                 3135             


Gly Ser  Arg Asp Ala Leu Asp  Leu Gly Ala Pro Arg  Glu Trp Leu 
    3140                 3145                 3150             


Ser Thr  Leu Pro Pro Pro Arg  Arg Thr Arg Asp Leu  Asp Pro Gln 
    3155                 3160                 3165             


Pro Pro  Pro Leu Pro Leu Ser  Pro Gln Arg Gln Leu  Ser Arg Asp 
    3170                 3175                 3180             


Pro Leu  Leu Pro Ser Arg Pro  Leu Asp Ser Leu Ser  Arg Ser Ser 
    3185                 3190                 3195             


Asn Ser  Arg Glu Gln Leu Asp  Gln Val Pro Ser Arg  His Pro Ser 
    3200                 3205                 3210             


Arg Glu  Ala Leu Gly Pro Leu  Pro Gln Leu Leu Arg  Ala Arg Glu 
    3215                 3220                 3225             


Asp Ser  Val Ser Gly Pro Ser  His Gly Pro Ser Thr  Glu Gln Leu 
    3230                 3235                 3240             


Asp Ile  Leu Ser Ser Ile Leu  Ala Ser Phe Asn Ser  Ser Ala Leu 
    3245                 3250                 3255             


Ser Ser  Val Gln Ser Ser Ser  Thr Pro Leu Gly Pro  His Thr Thr 
    3260                 3265                 3270             


Ala Thr  Pro Ser Ala Thr Ala  Ser Val Leu Gly Pro  Ser Thr Pro 
    3275                 3280                 3285             


Arg Ser  Ala Thr Ser His Ser  Ile Ser Glu Leu Ser  Pro Asp Ser 
    3290                 3295                 3300             


Glu Val  Pro Arg Ser Glu Gly  His Ser 
    3305                 3310         


<210>  173
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg 
1               5                   10                  15      


Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly 
            20                  25                  30          


Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile 
        35                  40                  45              


Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu 
    50                  55                  60                  


Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala 
65                  70                  75                  80  


Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe 
                85                  90                  95      


Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val 
            100                 105                 110         


Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu 
        115                 120                 125             


Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg 
    130                 135                 140                 


Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His 
145                 150                 155                 160 


Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His 
                165                 170                 175     


Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro 
            180                 185                 190         


Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp 
        195                 200                 205             


Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro 
    210                 215                 220                 


Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser 
225                 230                 235                 240 


Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser 
                245                 250                 255     


Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu 
            260                 265                 270         


Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly 
        275                 280                 285             


Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp 
    290                 295                 300                 


Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln 
305                 310                 315                 320 


Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu 
                325                 330                 335     


Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly 
            340                 345                 350         


Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg 
        355                 360                 365             


Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala 
    370                 375                 380                 


Ala Lys Lys Pro Thr Ala Ala Glu Ile Ser Val Arg Val Pro Arg Gly 
385                 390                 395                 400 


Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn 
                405                 410                 415     


Pro Pro Ser Glu Leu His Lys Val His Gly Ser Arg Asn Lys Pro Thr 
            420                 425                 430         


Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr 
        435                 440                 445             


Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Asp Arg Gly Asn 
    450                 455                 460                 


Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly 
465                 470                 475                 480 


Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala 
                485                 490                 495     


Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly 
            500                 505                 510         


Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala 
        515                 520                 525             


Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys 
    530                 535                 540                 


Asn Ser Met Asn Gln Pro Gly Pro 
545                 550         


<210>  174
<211>  1620
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  175
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Gly Glu Glu 
1               5                   10                  15      


Phe Tyr Glu Ala Ser Pro Tyr Glu Pro Val Thr Ser Arg Leu Ser Asp 
            20                  25                  30          


Ile Phe Arg Leu Ala Ser Ile Phe Ser Gly Thr Gly Ala Asp Pro Val 
        35                  40                  45              


Val Ser Ala Lys Ser Asn His Cys Leu Asp Ala Ala Lys Ala Cys Asn 
    50                  55                  60                  


Leu Asn Asp Asn Cys Lys Lys Leu Arg Ser Ser Tyr Ile Ser Ile Cys 
65                  70                  75                  80  


Asn Arg Glu Ile Ser Pro Thr Glu Arg Cys Asn Arg Arg Lys Cys His 
                85                  90                  95      


Lys Ala Leu Arg Gln Phe Phe Asp Arg Val Pro Ser Glu Tyr Thr Tyr 
            100                 105                 110         


Arg Met Leu Phe Cys Ser Cys Gln Asp Gln Ala Cys Ala Glu Arg Arg 
        115                 120                 125             


Arg Gln Thr Ile Leu Pro Ser Cys Ser Tyr Glu Asp Lys Glu Lys Pro 
    130                 135                 140                 


Asn Cys Leu Asp Leu Arg Gly Val Cys Arg Thr Asp His Leu Cys Arg 
145                 150                 155                 160 


Ser Arg Leu Ala Asp Phe His Ala Asn Cys Arg Ala Ser Tyr Gln Thr 
                165                 170                 175     


Val Thr Ser Cys Pro Ala Asp Asn Tyr Gln Ala Cys Leu Gly Ser Tyr 
            180                 185                 190         


Ala Gly Met Ile Gly Phe Asp Met Thr Pro Asn Tyr Val Asp Ser Ser 
        195                 200                 205             


Pro Thr Gly Ile Val Val Ser Pro Trp Cys Ser Cys Arg Gly Ser Gly 
    210                 215                 220                 


Asn Met Glu Glu Glu Cys Glu Lys Phe Leu Arg Asp Phe Thr Glu Asn 
225                 230                 235                 240 


Pro Cys Leu Arg Asn Ala Ile Gln Ala Phe Gly Asn Gly Thr Asp Val 
                245                 250                 255     


Asn Val Ser Pro Lys Gly Pro Ser Phe Gln Ala Thr Gln Ala Pro Arg 
            260                 265                 270         


Val Glu Lys Thr Pro Ser Leu Pro Asp Asp Leu Ser Asp Ser Thr Ser 
        275                 280                 285             


Leu Gly Thr Ser Val Ile Thr Thr Cys Thr Ser Val Gln Glu Gln Gly 
    290                 295                 300                 


Leu Lys Ala Asn Asn Ser Lys Glu Leu Ser Met Cys Phe Thr Glu Leu 
305                 310                 315                 320 


Thr Thr Asn Ile Ile Pro Gly Ser Asn Lys Val Ile Lys Pro Asn Ser 
                325                 330                 335     


Gly Pro Ser Arg Ala Arg Pro Ser Ala Ala Leu Thr Val Leu Ser Val 
            340                 345                 350         


Leu Met Leu Lys Leu Ala Leu 
        355                 


<210>  176
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Gly Thr Gly 
1               5                   10                  15      


Ala Asp Pro Val Val Ser Ala Lys Ser Asn His Cys Leu Asp Ala Ala 
            20                  25                  30          


Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys Leu Arg Ser Ser Tyr 
        35                  40                  45              


Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr Glu Arg Cys Asn Arg 
    50                  55                  60                  


Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe Asp Arg Val Pro Ser 
65                  70                  75                  80  


Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys Gln Asp Gln Ala Cys 
                85                  90                  95      


Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser Cys Ser Tyr Glu Asp 
            100                 105                 110         


Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly Val Cys Arg Thr Asp 
        115                 120                 125             


His Leu Cys Arg Ser Arg Leu Ala Asp Phe His Ala Asn Cys Arg Ala 
    130                 135                 140                 


Ser Tyr Gln Thr Val Thr Ser Cys Pro Ala Asp Asn Tyr Gln Ala Cys 
145                 150                 155                 160 


Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp Met Thr Pro Asn Tyr 
                165                 170                 175     


Val Asp Ser Ser Pro Thr Gly Ile Val Val Ser Pro Trp Cys Ser Cys 
            180                 185                 190         


Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu Lys Phe Leu Arg Asp 
        195                 200                 205             


Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile Gln Ala Phe Gly Asn 
    210                 215                 220                 


Gly Thr Asp Val Asn Val Ser Pro Lys Gly Pro Ser Phe Gln Ala Thr 
225                 230                 235                 240 


Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu Pro Asp Asp Leu Ser 
                245                 250                 255     


Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr Thr Cys Thr Ser Val 
            260                 265                 270         


Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys Glu Leu Ser Met Cys 
        275                 280                 285             


Phe Thr Glu Leu Thr Thr Asn Ile Ile Pro Gly Ser Asn Lys Val Ile 
    290                 295                 300                 


Lys Pro Asn Ser Gly Pro Ser Arg Ala Arg Pro Ser Ala Ala Leu Thr 
305                 310                 315                 320 


Val Leu Ser Val Leu Met Leu Lys Leu Ala Leu 
                325                 330     


<210>  177
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Asp Glu Thr 
1               5                   10                  15      


Leu Arg Ser Leu Ala Ser Pro Ser Ser Leu Gln Gly Pro Glu Leu His 
            20                  25                  30          


Gly Trp Arg Pro Pro Val Asp Cys Val Arg Ala Asn Glu Leu Cys Ala 
        35                  40                  45              


Ala Glu Ser Asn Cys Ser Ser Arg Tyr Arg Thr Leu Arg Gln Cys Leu 
    50                  55                  60                  


Ala Gly Arg Asp Arg Asn Thr Met Leu Ala Asn Lys Glu Cys Gln Ala 
65                  70                  75                  80  


Ala Leu Glu Val Leu Gln Glu Ser Pro Leu Tyr Asp Cys Arg Cys Lys 
                85                  90                  95      


Arg Gly Met Lys Lys Glu Leu Gln Cys Leu Gln Ile Tyr Trp Ser Ile 
            100                 105                 110         


His Leu Gly Leu Thr Glu Gly Glu Glu Phe Tyr Glu Ala Ser Pro Tyr 
        115                 120                 125             


Glu Pro Val Thr Ser Arg Leu Ser Asp Ile Phe Arg Leu Ala Ser Ile 
    130                 135                 140                 


Phe Ser Gly Thr Gly Ala Asp Pro Val Val Ser Ala Lys Ser Asn His 
145                 150                 155                 160 


Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys 
                165                 170                 175     


Leu Arg Ser Ser Tyr Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr 
            180                 185                 190         


Glu Arg Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
        195                 200                 205             


Asp Arg Val Pro Ser Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys 
    210                 215                 220                 


Gln Asp Gln Ala Cys Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser 
225                 230                 235                 240 


Cys Ser Tyr Glu Asp Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly 
                245                 250                 255     


Val Cys Arg Thr Asp His Leu Cys Arg Ser Arg Leu Ala Asp Phe His 
            260                 265                 270         


Ala Asn Cys Arg Ala Ser Tyr Gln Thr Val Thr Ser Cys Pro Ala Asp 
        275                 280                 285             


Asn Tyr Gln Ala Cys Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp 
    290                 295                 300                 


Met Thr Pro Asn Tyr Val Asp Ser Ser Pro Thr Gly Ile Val Val Ser 
305                 310                 315                 320 


Pro Trp Cys Ser Cys Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu 
                325                 330                 335     


Lys Phe Leu Arg Asp Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile 
            340                 345                 350         


Gln Ala Phe Gly Asn Gly Thr Asp Val Asn Val Ser Pro Lys Gly Pro 
        355                 360                 365             


Ser Phe Gln Ala Thr Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu 
    370                 375                 380                 


Pro Asp Asp Leu Ser Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr 
385                 390                 395                 400 


Thr Cys Thr Ser Val Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys 
                405                 410                 415     


Glu Leu Ser Met Cys Phe Thr Glu Leu Thr Thr Asn Ile Ile Pro Gly 
            420                 425                 430         


Ser Asn Lys Val Ile Lys Pro Asn Ser Gly Pro Ser Arg Ala Arg Pro 
        435                 440                 445             


Ser Ala Ala Leu Thr Val Leu Ser Val Leu Met Leu Lys Leu Ala Leu 
    450                 455                 460                 


<210>  178
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Thr Ala Thr Glu Ala Leu Leu Arg Val Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gly His Ser Thr Tyr Gly Ala Glu Cys Phe Pro Ala Cys Asn Pro 
            20                  25                  30          


Gln Asn Gly Phe Cys Glu Asp Asp Asn Val Cys Arg Cys Gln Pro Gly 
        35                  40                  45              


Trp Gln Gly Pro Leu Cys Asp Gln Cys Val Thr Ser Pro Gly Cys Leu 
    50                  55                  60                  


His Gly Leu Cys Gly Glu Pro Gly Gln Cys Ile Cys Thr Asp Gly Trp 
65                  70                  75                  80  


Asp Gly Glu Leu Cys Asp Arg Asp Val Arg Ala Cys Ser Ser Ala Pro 
                85                  90                  95      


Cys Ala Asn Asn Gly Thr Cys Val Ser Leu Asp Asp Gly Leu Tyr Glu 
            100                 105                 110         


Cys Ser Cys Ala Pro Gly Tyr Ser Gly Lys Asp Cys Gln Lys Lys Asp 
        115                 120                 125             


Gly Pro Cys Val Ile Asn Gly Ser Pro Cys Gln His Gly Gly Thr Cys 
    130                 135                 140                 


Val Asp Asp Glu Gly Arg Ala Ser His Ala Ser Cys Leu Cys Pro Pro 
145                 150                 155                 160 


Gly Phe Ser Gly Asn Phe Cys Glu Ile Val Ala Asn Ser Cys Thr Pro 
                165                 170                 175     


Asn Pro Cys Glu Asn Asp Gly Val Cys Thr Asp Ile Gly Gly Asp Phe 
            180                 185                 190         


Arg Cys Arg Cys Pro Ala Gly Phe Ile Asp Lys Thr Cys Ser Arg Pro 
        195                 200                 205             


Val Thr Asn Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Thr Cys Leu 
    210                 215                 220                 


Gln His Thr Gln Gly Gln Ala Ile Cys Phe Thr Ile Leu Gly Val Leu 
225                 230                 235                 240 


Thr Ser Leu Val Val Leu Gly Thr Val Gly Ile Val Phe Leu Asn Lys 
                245                 250                 255     


Cys Glu Thr Trp Val Ser Asn Leu Arg Tyr Asn His Met Leu Arg Lys 
            260                 265                 270         


Lys Lys Asn Leu Leu Leu Gln Tyr Asn Ser Gly Glu Asp Leu Ala Val 
        275                 280                 285             


Asn Ile Ile Phe Pro Glu Lys Ile Asp Met Thr Thr Phe Ser Lys Glu 
    290                 295                 300                 


Ala Gly Asp Glu Glu Ile 
305                 310 


<210>  179
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Thr Ala Thr Glu Ala Leu Leu Arg Val Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gly His Ser Thr Tyr Gly Ala Glu Cys Phe Pro Ala Cys Asn Pro 
            20                  25                  30          


Gln Asn Gly Phe Cys Glu Asp Asp Asn Val Cys Arg Cys Gln Pro Gly 
        35                  40                  45              


Trp Gln Gly Pro Leu Cys Asp Gln Cys Val Thr Ser Pro Gly Cys Leu 
    50                  55                  60                  


His Gly Leu Cys Gly Glu Pro Gly Gln Cys Ile Cys Thr Asp Gly Trp 
65                  70                  75                  80  


Asp Gly Glu Leu Cys Asp Arg Asp Val Arg Ala Cys Ser Ser Ala Pro 
                85                  90                  95      


Cys Ala Asn Asn Gly Thr Cys Val Ser Leu Asp Asp Gly Leu Tyr Glu 
            100                 105                 110         


Cys Ser Cys Ala Pro Gly Tyr Ser Gly Lys Asp Cys Gln Lys Lys Asp 
        115                 120                 125             


Gly Pro Cys Val Ile Asn Gly Ser Pro Cys Gln His Gly Gly Thr Cys 
    130                 135                 140                 


Val Asp Asp Glu Gly Arg Ala Ser His Ala Ser Cys Leu Cys Pro Pro 
145                 150                 155                 160 


Gly Phe Ser Gly Asn Phe Cys Glu Ile Val Ala Asn Ser Cys Thr Pro 
                165                 170                 175     


Asn Pro Cys Glu Asn Asp Gly Val Cys Thr Asp Ile Gly Gly Asp Phe 
            180                 185                 190         


Arg Cys Arg Cys Pro Ala Gly Phe Ile Asp Lys Thr Cys Ser Arg Pro 
        195                 200                 205             


Val Thr Asn Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Thr Cys Leu 
    210                 215                 220                 


Gln His Thr Gln Val Ser Tyr Glu Cys Leu Cys Lys Pro Glu Phe Thr 
225                 230                 235                 240 


Gly Leu Thr Cys Val Lys Lys Arg Ala Leu Ser Pro Gln Gln Val Thr 
                245                 250                 255     


Arg Leu Pro Ser Gly Tyr Gly Leu Ala Tyr Arg Leu Thr Pro Gly Val 
            260                 265                 270         


His Glu Leu Pro Val Gln Gln Pro Glu His Arg Ile Leu Lys Val Ser 
        275                 280                 285             


Met Lys Glu Leu Asn Lys Lys Thr Pro Leu Leu Thr Glu Gly Gln Ala 
    290                 295                 300                 


Ile Cys Phe Thr Ile Leu Gly Val Leu Thr Ser Leu Val Val Leu Gly 
305                 310                 315                 320 


Thr Val Gly Ile Val Phe Leu Asn Lys Cys Glu Thr Trp Val Ser Asn 
                325                 330                 335     


Leu Arg Tyr Asn His Met Leu Arg Lys Lys Lys Asn Leu Leu Leu Gln 
            340                 345                 350         


Tyr Asn Ser Gly Glu Asp Leu Ala Val Asn Ile Ile Phe Pro Glu Lys 
        355                 360                 365             


Ile Asp Met Thr Thr Phe Ser Lys Glu Ala Gly Asp Glu Glu Ile 
    370                 375                 380             


<210>  180
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Val Arg Pro Leu Asn Pro Arg Pro Leu Pro Pro Val Val Leu Met 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Pro Ser Pro Leu Pro Leu Ala Ala Gly Asp 
            20                  25                  30          


Pro Leu Pro Thr Glu Ser Arg Leu Met Asn Ser Cys Leu Gln Ala Arg 
        35                  40                  45              


Arg Lys Cys Gln Ala Asp Pro Thr Cys Ser Ala Ala Tyr His His Leu 
    50                  55                  60                  


Asp Ser Cys Thr Ser Ser Ile Ser Thr Pro Leu Pro Ser Glu Glu Pro 
65                  70                  75                  80  


Ser Val Pro Ala Asp Cys Leu Glu Ala Ala Gln Gln Leu Arg Asn Ser 
                85                  90                  95      


Ser Leu Ile Gly Cys Met Cys His Arg Arg Met Lys Asn Gln Val Ala 
            100                 105                 110         


Cys Leu Asp Ile Tyr Trp Thr Val His Arg Ala Arg Ser Leu Gly Asn 
        115                 120                 125             


Tyr Glu Leu Asp Val Ser Pro Tyr Glu Asp Thr Val Thr Ser Lys Pro 
    130                 135                 140                 


Trp Lys Met Asn Leu Ser Lys Leu Asn Met Leu Lys Pro Asp Ser Asp 
145                 150                 155                 160 


Leu Cys Leu Lys Phe Ala Met Leu Cys Thr Leu Asn Asp Lys Cys Asp 
                165                 170                 175     


Arg Leu Arg Lys Ala Tyr Gly Glu Ala Cys Ser Gly Pro His Cys Gln 
            180                 185                 190         


Arg His Val Cys Leu Arg Gln Leu Leu Thr Phe Phe Glu Lys Ala Ala 
        195                 200                 205             


Glu Pro His Ala Gln Gly Leu Leu Leu Cys Pro Cys Ala Pro Asn Asp 
    210                 215                 220                 


Arg Gly Cys Gly Glu Arg Arg Arg Asn Thr Ile Ala Pro Asn Cys Ala 
225                 230                 235                 240 


Leu Pro Pro Val Ala Pro Asn Cys Leu Glu Leu Arg Arg Leu Cys Phe 
                245                 250                 255     


Ser Asp Pro Leu Cys Arg Ser Arg Leu Val Asp Phe Gln Thr His Cys 
            260                 265                 270         


His Pro Met Asp Ile Leu Gly Thr Cys Ala Thr Glu Gln Ser Arg Cys 
        275                 280                 285             


Leu Arg Ala Tyr Leu Gly Leu Ile Gly Thr Ala Met Thr Pro Asn Phe 
    290                 295                 300                 


Val Ser Asn Val Asn Thr Ser Val Ala Leu Ser Cys Thr Cys Arg Gly 
305                 310                 315                 320 


Ser Gly Asn Leu Gln Glu Glu Cys Glu Met Leu Glu Gly Phe Phe Ser 
                325                 330                 335     


His Asn Pro Cys Leu Thr Glu Ala Ile Ala Ala Lys Met Arg Phe His 
            340                 345                 350         


Ser Gln Leu Phe Ser Gln Asp Trp Pro His Pro Thr Phe Ala Val Met 
        355                 360                 365             


Ala His Gln Asn Glu Asn Pro Ala Val Arg Pro Gln Pro Trp Val Pro 
    370                 375                 380                 


Ser Leu Phe Ser Cys Thr Leu Pro Leu Ile Leu Leu Leu Ser Leu Trp 
385                 390                 395                 400 


<210>  181
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Ala Asn Thr Thr Gly Glu Pro Glu Glu Val Ser Gly Ala Leu Ser 
1               5                   10                  15      


Pro Pro Ser Ala Ser Ala Tyr Val Lys Leu Val Leu Leu Gly Leu Ile 
            20                  25                  30          


Met Cys Val Ser Leu Ala Gly Asn Ala Ile Leu Ser Leu Leu Val Leu 
        35                  40                  45              


Lys Glu Arg Ala Leu His Lys Ala Pro Tyr Tyr Phe Leu Leu Asp Leu 
    50                  55                  60                  


Cys Leu Ala Asp Gly Ile Arg Ser Ala Val Cys Phe Pro Phe Val Leu 
65                  70                  75                  80  


Ala Ser Val Arg His Gly Ser Ser Trp Thr Phe Ser Ala Leu Ser Cys 
                85                  90                  95      


Lys Ile Val Ala Phe Met Ala Val Leu Phe Cys Phe His Ala Ala Phe 
            100                 105                 110         


Met Leu Phe Cys Ile Ser Val Thr Arg Tyr Met Ala Ile Ala His His 
        115                 120                 125             


Arg Phe Tyr Ala Lys Arg Met Thr Leu Trp Thr Cys Ala Ala Val Ile 
    130                 135                 140                 


Cys Met Ala Trp Thr Leu Ser Val Ala Met Ala Phe Pro Pro Val Phe 
145                 150                 155                 160 


Asp Val Gly Thr Tyr Lys Phe Ile Arg Glu Glu Asp Gln Cys Ile Phe 
                165                 170                 175     


Glu His Arg Tyr Phe Lys Ala Asn Asp Thr Leu Gly Phe Met Leu Met 
            180                 185                 190         


Leu Ala Val Leu Met Ala Ala Thr His Ala Val Tyr Gly Lys Leu Leu 
        195                 200                 205             


Leu Phe Glu Tyr Arg His Arg Lys Met Lys Pro Val Gln Met Val Pro 
    210                 215                 220                 


Ala Ile Ser Gln Asn Trp Thr Phe His Gly Pro Gly Ala Thr Gly Gln 
225                 230                 235                 240 


Ala Ala Ala Asn Trp Ile Ala Gly Phe Gly Arg Gly Pro Met Pro Pro 
                245                 250                 255     


Thr Leu Leu Gly Ile Arg Gln Asn Gly His Ala Ala Ser Arg Arg Leu 
            260                 265                 270         


Leu Gly Met Asp Glu Val Lys Gly Glu Lys Gln Leu Gly Arg Met Phe 
        275                 280                 285             


Tyr Ala Ile Thr Leu Leu Phe Leu Leu Leu Trp Ser Pro Tyr Ile Val 
    290                 295                 300                 


Ala Cys Tyr Trp Arg Val Phe Val Lys Ala Cys Ala Val Pro His Arg 
305                 310                 315                 320 


Tyr Leu Ala Thr Ala Val Trp Met Ser Phe Ala Gln Ala Ala Val Asn 
                325                 330                 335     


Pro Ile Val Cys Phe Leu Leu Asn Lys Asp Leu Lys Lys Cys Leu Arg 
            340                 345                 350         


Thr His Ala Pro Cys Trp Gly Thr Gly Gly Ala Pro Ala Pro Arg Glu 
        355                 360                 365             


Pro Tyr Cys Val Met 
    370             


<210>  182
<211>  1297
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Ala Val Pro Ser Leu Trp Pro Trp Gly Ala Cys Leu Pro Val Ile 
1               5                   10                  15      


Phe Leu Ser Leu Gly Phe Gly Leu Asp Thr Val Glu Val Cys Pro Ser 
            20                  25                  30          


Leu Asp Ile Arg Ser Glu Val Ala Glu Leu Arg Gln Leu Glu Asn Cys 
        35                  40                  45              


Ser Val Val Glu Gly His Leu Gln Ile Leu Leu Met Phe Thr Ala Thr 
    50                  55                  60                  


Gly Glu Asp Phe Arg Gly Leu Ser Phe Pro Arg Leu Thr Gln Val Thr 
65                  70                  75                  80  


Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu Glu Ser Leu Arg Asp 
                85                  90                  95      


Leu Phe Pro Asn Leu Ala Val Ile Arg Gly Thr Arg Leu Phe Leu Gly 
            100                 105                 110         


Tyr Ala Leu Val Ile Phe Glu Met Pro His Leu Arg Asp Val Ala Leu 
        115                 120                 125             


Pro Ala Leu Gly Ala Val Leu Arg Gly Ala Val Arg Val Glu Lys Asn 
    130                 135                 140                 


Gln Glu Leu Cys His Leu Ser Thr Ile Asp Trp Gly Leu Leu Gln Pro 
145                 150                 155                 160 


Ala Pro Gly Ala Asn His Ile Val Gly Asn Lys Leu Gly Glu Glu Cys 
                165                 170                 175     


Ala Asp Val Cys Pro Gly Val Leu Gly Ala Ala Gly Glu Pro Cys Ala 
            180                 185                 190         


Lys Thr Thr Phe Ser Gly His Thr Asp Tyr Arg Cys Trp Thr Ser Ser 
        195                 200                 205             


His Cys Gln Arg Val Cys Pro Cys Pro His Gly Met Ala Cys Thr Ala 
    210                 215                 220                 


Arg Gly Glu Cys Cys His Thr Glu Cys Leu Gly Gly Cys Ser Gln Pro 
225                 230                 235                 240 


Glu Asp Pro Arg Ala Cys Val Ala Cys Arg His Leu Tyr Phe Gln Gly 
                245                 250                 255     


Ala Cys Leu Trp Ala Cys Pro Pro Gly Thr Tyr Gln Tyr Glu Ser Trp 
            260                 265                 270         


Arg Cys Val Thr Ala Glu Arg Cys Ala Ser Leu His Ser Val Pro Gly 
        275                 280                 285             


Arg Ala Ser Thr Phe Gly Ile His Gln Gly Ser Cys Leu Ala Gln Cys 
    290                 295                 300                 


Pro Ser Gly Phe Thr Arg Asn Ser Ser Ser Ile Phe Cys His Lys Cys 
305                 310                 315                 320 


Glu Gly Leu Cys Pro Lys Glu Cys Lys Val Gly Thr Lys Thr Ile Asp 
                325                 330                 335     


Ser Ile Gln Ala Ala Gln Asp Leu Val Gly Cys Thr His Val Glu Gly 
            340                 345                 350         


Ser Leu Ile Leu Asn Leu Arg Gln Gly Tyr Asn Leu Glu Pro Gln Leu 
        355                 360                 365             


Gln His Ser Leu Gly Leu Val Glu Thr Ile Thr Gly Phe Leu Lys Ile 
    370                 375                 380                 


Lys His Ser Phe Ala Leu Val Ser Leu Gly Phe Phe Lys Asn Leu Lys 
385                 390                 395                 400 


Leu Ile Arg Gly Asp Ala Met Val Asp Gly Asn Tyr Thr Leu Tyr Val 
                405                 410                 415     


Leu Asp Asn Gln Asn Leu Gln Gln Leu Gly Ser Trp Val Ala Ala Gly 
            420                 425                 430         


Leu Thr Ile Pro Val Gly Lys Ile Tyr Phe Ala Phe Asn Pro Arg Leu 
        435                 440                 445             


Cys Leu Glu His Ile Tyr Arg Leu Glu Glu Val Thr Gly Thr Arg Gly 
    450                 455                 460                 


Arg Gln Asn Lys Ala Glu Ile Asn Pro Arg Thr Asn Gly Asp Arg Ala 
465                 470                 475                 480 


Ala Cys Gln Thr Arg Thr Leu Arg Phe Val Ser Asn Val Thr Glu Ala 
                485                 490                 495     


Asp Arg Ile Leu Leu Arg Trp Glu Arg Tyr Glu Pro Leu Glu Ala Arg 
            500                 505                 510         


Asp Leu Leu Ser Phe Ile Val Tyr Tyr Lys Glu Ser Pro Phe Gln Asn 
        515                 520                 525             


Ala Thr Glu His Val Gly Pro Asp Ala Cys Gly Thr Gln Ser Trp Asn 
    530                 535                 540                 


Leu Leu Asp Val Glu Leu Pro Leu Ser Arg Thr Gln Glu Pro Gly Val 
545                 550                 555                 560 


Thr Leu Ala Ser Leu Lys Pro Trp Thr Gln Tyr Ala Val Phe Val Arg 
                565                 570                 575     


Ala Ile Thr Leu Thr Thr Glu Glu Asp Ser Pro His Gln Gly Ala Gln 
            580                 585                 590         


Ser Pro Ile Val Tyr Leu Arg Thr Leu Pro Ala Ala Pro Thr Val Pro 
        595                 600                 605             


Gln Asp Val Ile Ser Thr Ser Asn Ser Ser Ser His Leu Leu Val Arg 
    610                 615                 620                 


Trp Lys Pro Pro Thr Gln Arg Asn Gly Asn Leu Thr Tyr Tyr Leu Val 
625                 630                 635                 640 


Leu Trp Gln Arg Leu Ala Glu Asp Gly Asp Leu Tyr Leu Asn Asp Tyr 
                645                 650                 655     


Cys His Arg Gly Leu Arg Leu Pro Thr Ser Asn Asn Asp Pro Arg Phe 
            660                 665                 670         


Asp Gly Glu Asp Gly Asp Pro Glu Ala Glu Met Glu Ser Asp Cys Cys 
        675                 680                 685             


Pro Cys Gln His Pro Pro Pro Gly Gln Val Leu Pro Pro Leu Glu Ala 
    690                 695                 700                 


Gln Glu Ala Ser Phe Gln Lys Lys Phe Glu Asn Phe Leu His Asn Ala 
705                 710                 715                 720 


Ile Thr Ile Pro Ile Ser Pro Trp Lys Val Thr Ser Ile Asn Lys Ser 
                725                 730                 735     


Pro Gln Arg Asp Ser Gly Arg His Arg Arg Ala Ala Gly Pro Leu Arg 
            740                 745                 750         


Leu Gly Gly Asn Ser Ser Asp Phe Glu Ile Gln Glu Asp Lys Val Pro 
        755                 760                 765             


Arg Glu Arg Ala Val Leu Ser Gly Leu Arg His Phe Thr Glu Tyr Arg 
    770                 775                 780                 


Ile Asp Ile His Ala Cys Asn His Ala Ala His Thr Val Gly Cys Ser 
785                 790                 795                 800 


Ala Ala Thr Phe Val Phe Ala Arg Thr Met Pro His Arg Glu Ala Asp 
                805                 810                 815     


Gly Ile Pro Gly Lys Val Ala Trp Glu Ala Ser Ser Lys Asn Ser Val 
            820                 825                 830         


Leu Leu Arg Trp Leu Glu Pro Pro Asp Pro Asn Gly Leu Ile Leu Lys 
        835                 840                 845             


Tyr Glu Ile Lys Tyr Arg Arg Leu Gly Glu Glu Ala Thr Val Leu Cys 
    850                 855                 860                 


Val Ser Arg Leu Arg Tyr Ala Lys Phe Gly Gly Val His Leu Ala Leu 
865                 870                 875                 880 


Leu Pro Pro Gly Asn Tyr Ser Ala Arg Val Arg Ala Thr Ser Leu Ala 
                885                 890                 895     


Gly Asn Gly Ser Trp Thr Asp Ser Val Ala Phe Tyr Ile Leu Gly Pro 
            900                 905                 910         


Glu Glu Glu Asp Ala Gly Gly Leu His Val Leu Leu Thr Ala Thr Pro 
        915                 920                 925             


Val Gly Leu Thr Leu Leu Ile Val Leu Ala Ala Leu Gly Phe Phe Tyr 
    930                 935                 940                 


Gly Lys Lys Arg Asn Arg Thr Leu Tyr Ala Ser Val Asn Pro Glu Tyr 
945                 950                 955                 960 


Phe Ser Ala Ser Asp Met Tyr Val Pro Asp Glu Trp Glu Val Pro Arg 
                965                 970                 975     


Glu Gln Ile Ser Ile Ile Arg Glu Leu Gly Gln Gly Ser Phe Gly Met 
            980                 985                 990         


Val Tyr Glu Gly Leu Ala Arg Gly  Leu Glu Ala Gly Glu  Glu Ser Thr 
        995                 1000                 1005             


Pro Val  Ala Leu Lys Thr Val  Asn Glu Leu Ala Ser  Pro Arg Glu 
    1010                 1015                 1020             


Cys Ile  Glu Phe Leu Lys Glu  Ala Ser Val Met Lys  Ala Phe Lys 
    1025                 1030                 1035             


Cys His  His Val Val Arg Leu  Leu Gly Val Val Ser  Gln Gly Gln 
    1040                 1045                 1050             


Pro Thr  Leu Val Ile Met Glu  Leu Met Thr Arg Gly  Asp Leu Lys 
    1055                 1060                 1065             


Ser His  Leu Arg Ser Leu Arg  Pro Glu Ala Glu Asn  Asn Pro Gly 
    1070                 1075                 1080             


Leu Pro  Gln Pro Ala Leu Gly  Glu Met Ile Gln Met  Ala Gly Glu 
    1085                 1090                 1095             


Ile Ala  Asp Gly Met Ala Tyr  Leu Ala Ala Asn Lys  Phe Val His 
    1100                 1105                 1110             


Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val Ser Gln  Asp Phe Thr 
    1115                 1120                 1125             


Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg Asp Val  Tyr Glu Thr 
    1130                 1135                 1140             


Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu Leu Pro  Val Arg Trp 
    1145                 1150                 1155             


Met Ala  Pro Glu Ser Leu Lys  Asp Gly Ile Phe Thr  Thr His Ser 
    1160                 1165                 1170             


Asp Val  Trp Ser Phe Gly Val  Val Leu Trp Glu Ile  Val Thr Leu 
    1175                 1180                 1185             


Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn Glu Gln  Val Leu Lys 
    1190                 1195                 1200             


Phe Val  Met Asp Gly Gly Val  Leu Glu Glu Leu Glu  Gly Cys Pro 
    1205                 1210                 1215             


Leu Gln  Leu Gln Glu Leu Met  Ser Arg Cys Trp Gln  Pro Asn Pro 
    1220                 1225                 1230             


Arg Leu  Arg Pro Ser Phe Thr  His Ile Leu Asp Ser  Ile Gln Glu 
    1235                 1240                 1245             


Glu Leu  Arg Pro Ser Phe Arg  Leu Leu Ser Phe Tyr  Tyr Ser Pro 
    1250                 1255                 1260             


Glu Cys  Arg Gly Ala Arg Gly  Ser Leu Pro Thr Thr  Asp Ala Glu 
    1265                 1270                 1275             


Pro Asp  Ser Ser Pro Thr Pro  Arg Asp Cys Ser Pro  Gln Asn Gly 
    1280                 1285                 1290             


Gly Pro  Gly His 
    1295         


<210>  183
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Lys Glu Ala Ala Leu Ile Cys Leu Ala Pro Ser Val Pro Pro Ile 
1               5                   10                  15      


Leu Thr Val Lys Ser Trp Asp Thr Met Gln Leu Arg Ala Ala Arg Ser 
            20                  25                  30          


Arg Cys Thr Asn Leu Leu Ala Ala Ser Tyr Ile Glu Asn Gln Gln His 
        35                  40                  45              


Leu Gln His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg 
    50                  55                  60                  


Asn Leu Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala 
65                  70                  75                  80  


Phe His Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala 
                85                  90                  95      


Leu Glu Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu 
            100                 105                 110         


Leu Val Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp 
        115                 120                 125             


Leu Gln Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys 
    130                 135                 140                 


Leu Gln Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser 
145                 150                 155                 160 


Cys Gly Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp 
                165                 170                 175     


Val Gly Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu 
            180                 185                 190         


Glu Gln Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val 
        195                 200                 205             


Met Lys Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val 
    210                 215                 220                 


Thr Ser Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp 
225                 230                 235                 240 


Val Gly Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala 
                245                 250                 255     


Ser Val Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro 
            260                 265                 270         


Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn 
        275                 280                 285             


Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu 
    290                 295                 300                 


Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln 
305                 310                 315                 320 


Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro 
                325                 330                 335     


Phe Gly Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro 
            340                 345                 350         


Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser 
        355                 360                 365             


Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val 
    370                 375                 380                 


Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu 
385                 390                 395                 400 


Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg 
                405                 410                 415     


Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe 
            420                 425                 430         


Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser 
        435                 440                 445             


Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala 
    450                 455                 460                 


Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu 
465                 470                 475                 480 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu 
                485                 490                 495     


Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu 
            500                 505                 510         


Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu 
        515                 520                 525             


Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr 
    530                 535                 540                 


Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp 
545                 550                 555                 560 


Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala 
                565                 570                 575     


Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu 
            580                 585                 590         


Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu 
        595                 600                 605             


His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln 
    610                 615                 620                 


Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr 
625                 630                 635                 640 


Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg 
                645                 650                 655     


Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser 
            660                 665                 670         


Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly 
        675                 680                 685             


Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile 
    690                 695                 700                 


Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val 
705                 710                 715                 720 


Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His 
                725                 730                 735     


Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro 
            740                 745                 750         


Pro Val Tyr Leu Asp Val Leu Gly 
        755                 760 


<210>  184
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser Gly Asp 
385                 390                 395                 400 


Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val Ala Val 
                405                 410                 415     


Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu Leu Val 
            420                 425                 430         


Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala 
        435                 440                 445             


Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met Thr 
    450                 455                 460                 


Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu 
465                 470                 475                 480 


Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val 
                485                 490                 495     


His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly Glu 
            500                 505                 510         


Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu Pro 
        515                 520                 525             


Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala Ser 
    530                 535                 540                 


Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Met 
545                 550                 555                 560 


Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu Gly 
                565                 570                 575     


Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu Asn 
            580                 585                 590         


Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly 
        595                 600                 605             


Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala Val 
    610                 615                 620                 


Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His Phe 
625                 630                 635                 640 


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly Leu 
                645                 650                 655     


Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr 
            660                 665                 670         


Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp Met 
        675                 680                 685             


Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
    690                 695                 700                 


Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
705                 710                 715                 720 


Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln 
                725                 730                 735     


Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala 
            740                 745                 750         


Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser Ile 
        755                 760                 765             


Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro Pro Val 
    770                 775                 780                 


Tyr Leu Asp Val Leu Gly 
785                 790 


<210>  185
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


<210>  186
<211>  658
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Leu Leu Lys Ile Ser Glu Ile Thr Met Pro Gly Lys Ile Phe Pro 
1               5                   10                  15      


Leu Lys Met Ala His Asp Leu Asp Thr Gly Ser Asn Gly Leu Gln Arg 
            20                  25                  30          


Tyr Thr Ile Ser Ser Asn Pro His Phe His Val Leu Thr Arg Asn Arg 
        35                  40                  45              


Ser Glu Gly Arg Lys Phe Pro Glu Leu Val Leu Asp Lys Pro Leu Asp 
    50                  55                  60                  


Arg Glu Glu Gln Pro Gln Leu Arg Leu Thr Leu Ile Ala Leu Asp Gly 
65                  70                  75                  80  


Gly Ser Pro Pro Arg Ser Gly Thr Ser Glu Ile Gln Ile Gln Val Leu 
                85                  90                  95      


Asp Ile Asn Asp Asn Val Pro Glu Phe Ala Gln Glu Leu Tyr Glu Ala 
            100                 105                 110         


Gln Val Pro Glu Asn Asn Pro Leu Gly Ser Leu Val Ile Thr Val Ser 
        115                 120                 125             


Ala Arg Asp Leu Asp Ala Gly Ser Phe Gly Lys Val Ser Tyr Ala Leu 
    130                 135                 140                 


Phe Gln Val Asp Asp Val Asn Gln Pro Phe Glu Ile Asn Ala Ile Thr 
145                 150                 155                 160 


Gly Glu Ile Arg Leu Arg Lys Ala Leu Asp Phe Glu Glu Ile Gln Ser 
                165                 170                 175     


Tyr Asp Val Asp Val Glu Ala Thr Asp Gly Gly Gly Leu Ser Gly Lys 
            180                 185                 190         


Cys Ser Leu Val Val Arg Val Leu Asp Val Asn Asp Asn Ala Pro Glu 
        195                 200                 205             


Leu Thr Met Ser Phe Phe Ile Ser Leu Ile Pro Glu Asn Leu Pro Glu 
    210                 215                 220                 


Ile Thr Val Ala Val Phe Ser Val Ser Asp Ala Asp Ser Gly His Asn 
225                 230                 235                 240 


Gln Gln Val Ile Cys Ser Ile Glu Asn Asn Leu Pro Phe Leu Leu Arg 
                245                 250                 255     


Pro Ser Val Glu Asn Phe Tyr Thr Leu Val Thr Glu Gly Ala Leu Asp 
            260                 265                 270         


Arg Glu Ser Arg Ala Glu Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu 
        275                 280                 285             


Gly Thr Pro Arg Leu Lys Thr Gln Gln Ser Ile Thr Val Gln Val Ser 
    290                 295                 300                 


Asp Val Asn Asp Asn Ala Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu 
305                 310                 315                 320 


Phe Val Arg Glu Asn Asn Ser Pro Ala Leu His Ile Gly Ser Val Ser 
                325                 330                 335     


Ala Thr Asp Arg Asp Ser Gly Ile Asn Ala Gln Val Thr Tyr Ser Leu 
            340                 345                 350         


Leu Pro Pro Gln Asp Pro His Leu Pro Leu Ser Ser Leu Val Ser Ile 
        355                 360                 365             


Asn Ala Asp Asn Gly His Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu 
    370                 375                 380                 


Ala Leu Gln Ser Phe Glu Phe Arg Val Gly Ala Thr Asp Arg Gly Ser 
385                 390                 395                 400 


Pro Ala Leu Ser Ser Glu Ala Leu Val Arg Leu Leu Val Leu Asp Ala 
                405                 410                 415     


Asn Asp Asn Ser Pro Phe Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala 
            420                 425                 430         


Pro Cys Thr Glu Leu Val Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val 
        435                 440                 445             


Thr Lys Val Val Ala Val Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu 
    450                 455                 460                 


Ser Tyr Gln Leu Leu Lys Ala Thr Glu Leu Gly Leu Phe Gly Val Trp 
465                 470                 475                 480 


Ala His Asn Gly Glu Val Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp 
                485                 490                 495     


Ala Ala Lys His Arg Leu Val Val Leu Val Lys Asp Asn Gly Glu Pro 
            500                 505                 510         


Pro Arg Ser Ala Thr Ala Thr Leu His Val Leu Leu Val Asp Gly Phe 
        515                 520                 525             


Ser Gln Pro Tyr Leu Pro Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln 
    530                 535                 540                 


Ala Asp Ser Leu Thr Val Tyr Leu Val Val Ala Leu Ala Ser Val Ser 
545                 550                 555                 560 


Ser Leu Phe Leu Phe Ser Val Leu Leu Phe Val Ala Val Arg Leu Cys 
                565                 570                 575     


Arg Arg Ser Arg Ala Ala Ser Val Gly Arg Tyr Ser Val Pro Glu Gly 
            580                 585                 590         


Pro Phe Pro Gly His Leu Val Asp Val Ser Gly Thr Gly Thr Leu Ser 
        595                 600                 605             


Gln Ser Tyr Gln Tyr Lys Val Cys Leu Thr Gly Gly Ser Glu Thr Asn 
    610                 615                 620                 


Glu Phe Lys Phe Leu Lys Pro Ile Met Pro Asn Phe Pro Pro Gln Gly 
625                 630                 635                 640 


Thr Glu Arg Glu Met Glu Glu Thr Pro Thr Ser Arg Asn Ser Phe Pro 
                645                 650                 655     


Phe Ser 
        


<210>  187
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Met Gln Thr Lys Val Gln Asn Lys Lys Arg Gln Val Ala Phe Phe 
1               5                   10                  15      


Ile Leu Leu Met Leu Trp Gly Glu Val Gly Ser Glu Ser Ile Gln Tyr 
            20                  25                  30          


Ser Val Leu Glu Glu Thr Glu Ser Gly Thr Phe Val Ala Asn Leu Thr 
        35                  40                  45              


Lys Asp Leu Gly Leu Arg Val Gly Glu Leu Ala Ser Arg Gly Ala Arg 
    50                  55                  60                  


Val Val Phe Lys Gly Asn Arg Gln His Leu Gln Phe Asp Pro Gln Thr 
65                  70                  75                  80  


His Asp Leu Leu Leu Asn Glu Lys Leu Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Ser Thr Glu Pro Cys Val Leu Pro Phe Gln Val Leu Leu Glu Asn Pro 
            100                 105                 110         


Leu Gln Phe Phe Gln Ala Ser Leu Arg Val Arg Asp Ile Asn Asp His 
        115                 120                 125             


Ala Pro Glu Phe Pro Ala Arg Glu Met Leu Leu Lys Ile Ser Glu Ile 
    130                 135                 140                 


Thr Met Pro Gly Lys Ile Phe Pro Leu Lys Met Ala His Asp Leu Asp 
145                 150                 155                 160 


Thr Gly Ser Asn Gly Leu Gln Arg Tyr Thr Ile Ser Ser Asn Pro His 
                165                 170                 175     


Phe His Val Leu Thr Arg Asn Arg Ser Glu Gly Arg Lys Phe Pro Glu 
            180                 185                 190         


Leu Val Leu Asp Lys Pro Leu Asp Arg Glu Glu Gln Pro Gln Leu Arg 
        195                 200                 205             


Leu Thr Leu Ile Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly Thr 
    210                 215                 220                 


Ser Glu Ile Gln Ile Gln Val Leu Asp Ile Asn Asp Asn Val Pro Glu 
225                 230                 235                 240 


Phe Ala Gln Glu Leu Tyr Glu Ala Gln Val Pro Glu Asn Asn Pro Leu 
                245                 250                 255     


Gly Ser Leu Val Ile Thr Val Ser Ala Arg Asp Leu Asp Ala Gly Ser 
            260                 265                 270         


Phe Gly Lys Val Ser Tyr Ala Leu Phe Gln Val Asp Asp Val Asn Gln 
        275                 280                 285             


Pro Phe Glu Ile Asn Ala Ile Thr Gly Glu Ile Arg Leu Arg Lys Ala 
    290                 295                 300                 


Leu Asp Phe Glu Glu Ile Gln Ser Tyr Asp Val Asp Val Glu Ala Thr 
305                 310                 315                 320 


Asp Gly Gly Gly Leu Ser Gly Lys Cys Ser Leu Val Val Arg Val Leu 
                325                 330                 335     


Asp Val Asn Asp Asn Ala Pro Glu Leu Thr Met Ser Phe Phe Ile Ser 
            340                 345                 350         


Leu Ile Pro Glu Asn Leu Pro Glu Ile Thr Val Ala Val Phe Ser Val 
        355                 360                 365             


Ser Asp Ala Asp Ser Gly His Asn Gln Gln Val Ile Cys Ser Ile Glu 
    370                 375                 380                 


Asn Asn Leu Pro Phe Leu Leu Arg Pro Ser Val Glu Asn Phe Tyr Thr 
385                 390                 395                 400 


Leu Val Thr Glu Gly Ala Leu Asp Arg Glu Ser Arg Ala Glu Tyr Asn 
                405                 410                 415     


Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys Thr Gln 
            420                 425                 430         


Gln Ser Ile Thr Val Gln Val Ser Asp Val Asn Asp Asn Ala Pro Ala 
        435                 440                 445             


Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn Ser Pro 
    450                 455                 460                 


Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser Gly Ile 
465                 470                 475                 480 


Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro His Leu 
                485                 490                 495     


Pro Leu Ser Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His Leu Phe 
            500                 505                 510         


Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ser Phe Glu Phe Arg 
        515                 520                 525             


Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu Ala Leu 
    530                 535                 540                 


Val Arg Leu Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe Val Leu 
545                 550                 555                 560 


Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val Pro Arg 
                565                 570                 575     


Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Gly 
            580                 585                 590         


Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys Ala Thr 
        595                 600                 605             


Glu Leu Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val Arg Thr 
    610                 615                 620                 


Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu Val Val 
625                 630                 635                 640 


Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala Thr Leu 
                645                 650                 655     


His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro Leu Pro 
            660                 665                 670         


Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val Tyr Leu 
        675                 680                 685             


Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser Val Leu 
    690                 695                 700                 


Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Ser Val 
705                 710                 715                 720 


Gly Arg Tyr Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu Val Asp 
                725                 730                 735     


Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Lys Val Cys 
            740                 745                 750         


Leu Thr Gly Gly Ser Glu Thr Asn Glu Phe Lys Phe Leu Lys Pro Ile 
        755                 760                 765             


Met Pro Asn Phe Pro Pro Gln Gly Thr Glu Arg Glu Met Glu Glu Thr 
    770                 775                 780                 


Pro Thr Ser Arg Asn Ser Phe Pro Phe Ser 
785                 790                 


<210>  188
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ala Gly Ala Gly Gly Gly Leu Gly Val Trp Gly Asn Leu Val Leu 
1               5                   10                  15      


Leu Gly Leu Cys Ser Trp Thr Gly Ala Arg Ala Pro Ala Pro Asn Pro 
            20                  25                  30          


Gly Arg Asn Leu Thr Val Glu Thr Gln Thr Thr Ser Ser Ile Ser Leu 
        35                  40                  45              


Ser Trp Glu Val Pro Asp Gly Leu Asp Ser Gln Asn Ser Asn Tyr Trp 
    50                  55                  60                  


Val Gln Cys Thr Gly Asp Gly Gly Thr Thr Glu Thr Arg Asn Thr Thr 
65                  70                  75                  80  


Ala Thr Asn Val Thr Val Asp Gly Leu Gly Pro Gly Ser Leu Tyr Thr 
                85                  90                  95      


Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser Val Gly Thr 
            100                 105                 110         


Val Thr Thr Ala Thr Ala Pro Asn Pro Val Arg Asn Leu Thr Val Glu 
        115                 120                 125             


Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val Pro Asp Gly 
    130                 135                 140                 


Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr Gly Asp Gly 
145                 150                 155                 160 


Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile Thr Val Asp 
                165                 170                 175     


Arg Leu Glu Pro Gly Cys Leu Tyr Val Phe Ser Val Trp Val Gly Lys 
            180                 185                 190         


Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr Thr Ala Pro 
        195                 200                 205             


Asn Pro Val Arg Asn Leu His Met Glu Thr Gln Thr Asn Ser Ser Ile 
    210                 215                 220                 


Ala Leu Cys Trp Glu Val Pro Asp Gly Pro Tyr Pro Gln Asp Tyr Thr 
225                 230                 235                 240 


Tyr Trp Val Glu Tyr Thr Gly Asp Gly Gly Gly Thr Glu Thr Arg Asn 
                245                 250                 255     


Thr Thr Asn Thr Ser Val Thr Ala Glu Arg Leu Glu Pro Gly Thr Leu 
            260                 265                 270         


Tyr Thr Phe Ser Val Trp Ala Glu Lys Asn Gly Ala Arg Gly Ser Arg 
        275                 280                 285             


Gln Asn Val Ser Ile Ser Thr Val Pro Asn Ala Val Thr Ser Leu Ser 
    290                 295                 300                 


Lys Gln Asp Trp Thr Asn Ser Thr Ile Ala Leu Arg Trp Thr Ala Pro 
305                 310                 315                 320 


Gln Gly Pro Gly Gln Ser Ser Tyr Ser Tyr Trp Val Ser Trp Val Arg 
                325                 330                 335     


Glu Gly Met Thr Asp Pro Arg Thr Gln Ser Thr Ser Gly Thr Asp Ile 
            340                 345                 350         


Thr Leu Lys Glu Leu Glu Ala Gly Ser Leu Tyr His Leu Thr Val Trp 
        355                 360                 365             


Ala Glu Arg Asn Glu Val Arg Gly Tyr Asn Ser Thr Leu Thr Ala Ala 
    370                 375                 380                 


Thr Ala Pro Asn Glu Val Thr Asp Leu Gln Asn Glu Thr Gln Thr Lys 
385                 390                 395                 400 


Asn Ser Val Met Leu Trp Trp Lys Ala Pro Gly Asp Pro His Ser Gln 
                405                 410                 415     


Leu Tyr Val Tyr Trp Val Gln Trp Ala Ser Lys Gly His Pro Arg Arg 
            420                 425                 430         


Gly Gln Asp Pro Gln Ala Asn Trp Val Asn Gln Thr Ser Arg Thr Asn 
        435                 440                 445             


Glu Thr Trp Tyr Lys Val Glu Ala Leu Glu Pro Gly Thr Leu Tyr Asn 
    450                 455                 460                 


Phe Thr Val Trp Ala Glu Arg Asn Asp Val Ala Ser Ser Thr Gln Ser 
465                 470                 475                 480 


Leu Cys Ala Ser Thr Tyr Pro Asp Thr Val Thr Ile Thr Ser Cys Val 
                485                 490                 495     


Ser Thr Ser Ala Gly Tyr Gly Val Asn Leu Ile Trp Ser Cys Pro Gln 
            500                 505                 510         


Gly Gly Tyr Glu Ala Phe Glu Leu Glu Val Gly Gly Gln Arg Gly Ser 
        515                 520                 525             


Gln Asp Arg Ser Ser Cys Gly Glu Ala Val Ser Val Leu Gly Leu Gly 
    530                 535                 540                 


Pro Ala Arg Ser Tyr Pro Ala Thr Ile Thr Thr Ile Trp Asp Gly Met 
545                 550                 555                 560 


Lys Val Val Ser His Ser Val Val Cys His Thr Glu Ser Ala Gly Val 
                565                 570                 575     


Ile Ala Gly Ala Phe Val Gly Ile Leu Leu Phe Leu Ile Leu Val Gly 
            580                 585                 590         


Leu Leu Ile Phe Phe Leu Lys Arg Arg Asn Lys Lys Lys Gln Gln Lys 
        595                 600                 605             


Pro Glu Leu Arg Asp Leu Val Phe Ser Ser Pro Gly Asp Ile Pro Ala 
    610                 615                 620                 


Glu Asp Phe Ala Asp His Val Arg Lys Asn Glu Arg Asp Ser Asn Cys 
625                 630                 635                 640 


Gly Phe Ala Asp Glu Tyr Gln Gln Leu Ser Leu Val Gly His Ser Gln 
                645                 650                 655     


Ser Gln Met Val Ala Ser Ala Ser Glu Asn Asn Ala Lys Asn Arg Tyr 
            660                 665                 670         


Arg Asn Val Leu Pro Tyr Asp Trp Ser Arg Val Pro Leu Lys Pro Ile 
        675                 680                 685             


His Glu Glu Pro Gly Ser Asp Tyr Ile Asn Ala Ser Phe Met Pro Gly 
    690                 695                 700                 


Leu Trp Ser Pro Gln Glu Phe Ile Ala Thr Gln Gly Pro Leu Pro Gln 
705                 710                 715                 720 


Thr Val Gly Asp Phe Trp Arg Leu Val Trp Glu Gln Gln Ser His Thr 
                725                 730                 735     


Leu Val Met Leu Thr Asn Cys Met Glu Ala Gly Arg Val Lys Cys Glu 
            740                 745                 750         


His Tyr Trp Pro Leu Asp Ser Gln Pro Cys Thr His Gly His Leu Arg 
        755                 760                 765             


Val Thr Leu Val Gly Glu Glu Val Met Glu Asn Trp Thr Val Arg Glu 
    770                 775                 780                 


Leu Leu Leu Leu Gln Val Glu Glu Gln Lys Thr Leu Ser Val Arg Gln 
785                 790                 795                 800 


Phe His Tyr Gln Ala Trp Pro Asp His Gly Val Pro Ser Ser Pro Asp 
                805                 810                 815     


Thr Leu Leu Ala Phe Trp Arg Met Leu Arg Gln Trp Leu Asp Gln Thr 
            820                 825                 830         


Met Glu Gly Gly Pro Pro Ile Val His Cys Ser Ala Gly Val Gly Arg 
        835                 840                 845             


Thr Gly Thr Leu Ile Ala Leu Asp Val Leu Leu Arg Gln Leu Gln Ser 
    850                 855                 860                 


Glu Gly Leu Leu Gly Pro Phe Ser Phe Val Arg Lys Met Arg Glu Ser 
865                 870                 875                 880 


Arg Pro Leu Met Val Gln Thr Glu Ala Gln Tyr Val Phe Leu His Gln 
                885                 890                 895     


Cys Ile Leu Arg Phe Leu Gln Gln Ser Ala Gln Ala Pro Ala Glu Lys 
            900                 905                 910         


Glu Val Pro Tyr Glu Asp Val Glu Asn Leu Ile Tyr Glu Asn Val Ala 
        915                 920                 925             


Ala Ile Gln Ala His Lys Leu Glu Val 
    930                 935         


<210>  189
<211>  1115
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Ala Gly Ala Gly Gly Gly Leu Gly Val Trp Gly Asn Leu Val Leu 
1               5                   10                  15      


Leu Gly Leu Cys Ser Trp Thr Gly Ala Arg Ala Pro Ala Pro Asn Pro 
            20                  25                  30          


Gly Arg Asn Leu Thr Val Glu Thr Gln Thr Thr Ser Ser Ile Ser Leu 
        35                  40                  45              


Ser Trp Glu Val Pro Asp Gly Leu Asp Ser Gln Asn Ser Asn Tyr Trp 
    50                  55                  60                  


Val Gln Cys Thr Gly Asp Gly Gly Thr Thr Glu Thr Arg Asn Thr Thr 
65                  70                  75                  80  


Ala Thr Asn Val Thr Val Asp Gly Leu Gly Pro Gly Ser Leu Tyr Thr 
                85                  90                  95      


Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser Val Gly Thr 
            100                 105                 110         


Val Thr Thr Ala Thr Ala Pro Asn Pro Val Arg Asn Leu Arg Val Glu 
        115                 120                 125             


Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val Pro Asp Gly 
    130                 135                 140                 


Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr Gly Asp Gly 
145                 150                 155                 160 


Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile Thr Val Asp 
                165                 170                 175     


Gly Leu Glu Pro Gly Cys Leu Tyr Ala Phe Ser Met Trp Val Gly Lys 
            180                 185                 190         


Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr Thr Ala His 
        195                 200                 205             


Asn Pro Val Arg Asn Leu Arg Val Glu Ala Gln Thr Thr Ser Ser Ile 
    210                 215                 220                 


Ser Leu Ser Trp Glu Val Pro Asp Gly Thr Asp Pro Gln Asn Ser Thr 
225                 230                 235                 240 


Tyr Cys Val Gln Cys Thr Gly Asp Gly Gly Arg Thr Glu Thr Arg Asn 
                245                 250                 255     


Thr Thr Asp Thr Arg Val Thr Val Asp Gly Leu Gly Pro Gly Ser Leu 
            260                 265                 270         


Tyr Thr Cys Ser Val Trp Val Glu Lys Asp Gly Val Asn Ser Ser Val 
        275                 280                 285             


Glu Ile Val Thr Ser Ala Thr Ala Pro Asn Pro Val Arg Asn Leu Thr 
    290                 295                 300                 


Val Glu Ala Gln Thr Asn Ser Ser Ile Ala Leu Thr Trp Glu Val Pro 
305                 310                 315                 320 


Asp Gly Pro Asp Pro Gln Asn Ser Thr Tyr Gly Val Glu Tyr Thr Gly 
                325                 330                 335     


Asp Gly Gly Arg Ala Gly Thr Arg Ser Thr Ala His Thr Asn Ile Thr 
            340                 345                 350         


Val Asp Arg Leu Glu Pro Gly Cys Leu Tyr Val Phe Ser Val Trp Val 
        355                 360                 365             


Gly Lys Asn Gly Ile Asn Ser Ser Arg Glu Thr Arg Asn Ala Thr Thr 
    370                 375                 380                 


Ala Pro Asn Pro Val Arg Asn Leu His Met Glu Thr Gln Thr Asn Ser 
385                 390                 395                 400 


Ser Ile Ala Leu Cys Trp Glu Val Pro Asp Gly Pro Tyr Pro Gln Asp 
                405                 410                 415     


Tyr Thr Tyr Trp Val Glu Tyr Thr Gly Asp Gly Gly Gly Thr Glu Thr 
            420                 425                 430         


Arg Asn Thr Thr Asn Thr Ser Val Thr Ala Glu Arg Leu Glu Pro Gly 
        435                 440                 445             


Thr Leu Tyr Thr Phe Ser Val Trp Ala Glu Lys Asn Gly Ala Arg Gly 
    450                 455                 460                 


Ser Arg Gln Asn Val Ser Ile Ser Thr Val Pro Asn Ala Val Thr Ser 
465                 470                 475                 480 


Leu Ser Lys Gln Asp Trp Thr Asn Ser Thr Ile Ala Leu Arg Trp Thr 
                485                 490                 495     


Ala Pro Gln Gly Pro Gly Gln Ser Ser Tyr Ser Tyr Trp Val Ser Trp 
            500                 505                 510         


Val Arg Glu Gly Met Thr Asp Pro Arg Thr Gln Ser Thr Ser Gly Thr 
        515                 520                 525             


Asp Ile Thr Leu Lys Glu Leu Glu Ala Gly Ser Leu Tyr His Leu Thr 
    530                 535                 540                 


Val Trp Ala Glu Arg Asn Glu Val Arg Gly Tyr Asn Ser Thr Leu Thr 
545                 550                 555                 560 


Ala Ala Thr Ala Pro Asn Glu Val Thr Asp Leu Gln Asn Glu Thr Gln 
                565                 570                 575     


Thr Lys Asn Ser Val Met Leu Trp Trp Lys Ala Pro Gly Asp Pro His 
            580                 585                 590         


Ser Gln Leu Tyr Val Tyr Trp Val Gln Trp Ala Ser Lys Gly His Pro 
        595                 600                 605             


Arg Arg Gly Gln Asp Pro Gln Ala Asn Trp Val Asn Gln Thr Ser Arg 
    610                 615                 620                 


Thr Asn Glu Thr Trp Tyr Lys Val Glu Ala Leu Glu Pro Gly Thr Leu 
625                 630                 635                 640 


Tyr Asn Phe Thr Val Trp Ala Glu Arg Asn Asp Val Ala Ser Ser Thr 
                645                 650                 655     


Gln Ser Leu Cys Ala Ser Thr Tyr Pro Asp Thr Val Thr Ile Thr Ser 
            660                 665                 670         


Cys Val Ser Thr Ser Ala Gly Tyr Gly Val Asn Leu Ile Trp Ser Cys 
        675                 680                 685             


Pro Gln Gly Gly Tyr Glu Ala Phe Glu Leu Glu Val Gly Gly Gln Arg 
    690                 695                 700                 


Gly Ser Gln Asp Arg Ser Ser Cys Gly Glu Ala Val Ser Val Leu Gly 
705                 710                 715                 720 


Leu Gly Pro Ala Arg Ser Tyr Pro Ala Thr Ile Thr Thr Ile Trp Asp 
                725                 730                 735     


Gly Met Lys Val Val Ser His Ser Val Val Cys His Thr Glu Ser Ala 
            740                 745                 750         


Gly Val Ile Ala Gly Ala Phe Val Gly Ile Leu Leu Phe Leu Ile Leu 
        755                 760                 765             


Val Gly Leu Leu Ile Phe Phe Leu Lys Arg Arg Asn Lys Lys Lys Gln 
    770                 775                 780                 


Gln Lys Pro Glu Leu Arg Asp Leu Val Phe Ser Ser Pro Gly Asp Ile 
785                 790                 795                 800 


Pro Ala Glu Asp Phe Ala Asp His Val Arg Lys Asn Glu Arg Asp Ser 
                805                 810                 815     


Asn Cys Gly Phe Ala Asp Glu Tyr Gln Gln Leu Ser Leu Val Gly His 
            820                 825                 830         


Ser Gln Ser Gln Met Val Ala Ser Ala Ser Glu Asn Asn Ala Lys Asn 
        835                 840                 845             


Arg Tyr Arg Asn Val Leu Pro Tyr Asp Trp Ser Arg Val Pro Leu Lys 
    850                 855                 860                 


Pro Ile His Glu Glu Pro Gly Ser Asp Tyr Ile Asn Ala Ser Phe Met 
865                 870                 875                 880 


Pro Gly Leu Trp Ser Pro Gln Glu Phe Ile Ala Thr Gln Gly Pro Leu 
                885                 890                 895     


Pro Gln Thr Val Gly Asp Phe Trp Arg Leu Val Trp Glu Gln Gln Ser 
            900                 905                 910         


His Thr Leu Val Met Leu Thr Asn Cys Met Glu Ala Gly Arg Val Lys 
        915                 920                 925             


Cys Glu His Tyr Trp Pro Leu Asp Ser Gln Pro Cys Thr His Gly His 
    930                 935                 940                 


Leu Arg Val Thr Leu Val Gly Glu Glu Val Met Glu Asn Trp Thr Val 
945                 950                 955                 960 


Arg Glu Leu Leu Leu Leu Gln Val Glu Glu Gln Lys Thr Leu Ser Val 
                965                 970                 975     


Arg Gln Phe His Tyr Gln Ala Trp Pro Asp His Gly Val Pro Ser Ser 
            980                 985                 990         


Pro Asp Thr Leu Leu Ala Phe Trp  Arg Met Leu Arg Gln  Trp Leu Asp 
        995                 1000                 1005             


Gln Thr  Met Glu Gly Gly Pro  Pro Ile Val His Cys  Ser Ala Gly 
    1010                 1015                 1020             


Val Gly  Arg Thr Gly Thr Leu  Ile Ala Leu Asp Val  Leu Leu Arg 
    1025                 1030                 1035             


Gln Leu  Gln Ser Glu Gly Leu  Leu Gly Pro Phe Ser  Phe Val Arg 
    1040                 1045                 1050             


Lys Met  Arg Glu Ser Arg Pro  Leu Met Val Gln Thr  Glu Ala Gln 
    1055                 1060                 1065             


Tyr Val  Phe Leu His Gln Cys  Ile Leu Arg Phe Leu  Gln Gln Ser 
    1070                 1075                 1080             


Ala Gln  Ala Pro Ala Glu Lys  Glu Val Pro Tyr Glu  Asp Val Glu 
    1085                 1090                 1095             


Asn Leu  Ile Tyr Glu Asn Val  Ala Ala Ile Gln Ala  His Lys Leu 
    1100                 1105                 1110             


Glu Val  
    1115 


<210>  190
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Gln Val Arg Glu Leu Pro Arg Gly Glu Trp Gln Thr Tyr Ser Ser 
1               5                   10                  15      


Ser Ile Ser His Glu Ala Thr Ala Cys Val Val Asp Arg Leu Arg Pro 
            20                  25                  30          


Phe Thr Ser Tyr Lys Leu Arg Leu Lys Ala Thr Asn Asp Ile Gly Asp 
        35                  40                  45              


Ser Asp Phe Ser Ser Glu Thr Glu Ala Val Thr Thr Leu Gln Asp Val 
    50                  55                  60                  


Pro Gly Glu Pro Pro Gly Ser Val Ser Ala Thr Pro His Thr Thr Ser 
65                  70                  75                  80  


Ser Val Leu Ile Gln Trp Gln Pro Pro Arg Asp Glu Ser Leu Asn Gly 
                85                  90                  95      


Leu Leu Gln Gly Tyr Arg Ile Tyr Tyr Arg Glu Leu Glu Tyr Glu Ala 
            100                 105                 110         


Gly Ser Gly Thr Glu Ala Lys Thr Leu Lys Asn Pro Ile Ala Leu His 
        115                 120                 125             


Ala Glu Leu Thr Ala Gln Ser Ser Phe Lys Thr Val Asn Ser Ser Ser 
    130                 135                 140                 


Thr Ser Thr Met Cys Glu Leu Thr His Leu Lys Lys Tyr Arg Arg Tyr 
145                 150                 155                 160 


Glu Val Ile Met Thr Ala Tyr Asn Ile Ile Gly Glu Ser Pro Ala Ser 
                165                 170                 175     


Ala Pro Val Glu Val Phe Val Gly Glu Ala Ala Pro Ala Met Ala Pro 
            180                 185                 190         


Gln Asn Val Gln Val Thr Pro Leu Thr Ala Ser Gln Leu Glu Val Thr 
        195                 200                 205             


Trp Asp Pro Pro Pro Pro Glu Ser Gln Asn Gly Asn Ile Gln Gly Tyr 
    210                 215                 220                 


Lys Ile Tyr Tyr Trp Glu Ala Asp Ser Gln Asn Glu Thr Glu Lys Met 
225                 230                 235                 240 


Lys Val Leu Phe Leu Pro Glu Pro Val Val Arg Leu Lys Asn Leu Thr 
                245                 250                 255     


Ser His Thr Lys Tyr Leu Val Ser Ile Ser Ala Phe Asn Ala Ala Gly 
            260                 265                 270         


Asp Gly Pro Lys Ser Asp Pro Gln Gln Gly Arg Thr His Gln Ala Ala 
        275                 280                 285             


Pro Gly Ala Pro Ser Phe Leu Ala Phe Ser Glu Ile Thr Ser Thr Thr 
    290                 295                 300                 


Leu Asn Val Ser Trp Gly Glu Pro Ala Ala Ala Asn Gly Ile Leu Gln 
305                 310                 315                 320 


Gly Tyr Arg Val Val Tyr Glu Pro Leu Ala Pro Val Gln Gly Val Ser 
                325                 330                 335     


Lys Val Val Thr Val Glu Val Arg Gly Asn Trp Gln Arg Trp Leu Lys 
            340                 345                 350         


Val Arg Asp Leu Thr Lys Gly Val Thr Tyr Phe Phe Arg Val Gln Ala 
        355                 360                 365             


Arg Thr Ile Thr Tyr Gly Pro Glu Leu Gln Ala Asn Ile Thr Ala Gly 
    370                 375                 380                 


Pro Ala Glu Gly Ser Pro Gly Ser Pro Arg Asp Val Leu Val Thr Lys 
385                 390                 395                 400 


Ser Ala Ser Glu Leu Thr Leu Gln Trp Thr Glu Gly His Ser Gly Asp 
                405                 410                 415     


Thr Pro Thr Thr Gly Tyr Val Ile Glu Ala Arg Pro Ser Asp Glu Gly 
            420                 425                 430         


Leu Trp Asp Met Phe Val Lys Asp Ile Pro Arg Ser Ala Thr Ser Tyr 
        435                 440                 445             


Thr Leu Ser Leu Asp Lys Leu Arg Gln Gly Val Thr Tyr Glu Phe Arg 
    450                 455                 460                 


Val Val Ala Val Asn Glu Ala Gly Tyr Gly Glu Pro Ser Asn Pro Ser 
465                 470                 475                 480 


Thr Ala Val Ser Ala Gln Val Glu Ala Pro Phe Tyr Glu Glu Trp Trp 
                485                 490                 495     


Phe Leu Leu Val Met Ala Leu Ser Ser Leu Ile Val Ile Leu Leu Val 
            500                 505                 510         


Val Phe Ala Leu Val Leu His Gly Gln Asn Lys Lys Tyr Lys Asn Cys 
        515                 520                 525             


Ser Thr Gly Lys Gly Ile Ser Thr Met Glu Glu Ser Val Thr Leu Asp 
    530                 535                 540                 


Asn Gly Gly Phe Ala Ala Leu Glu Leu Ser Ser Arg His Leu Asn Val 
545                 550                 555                 560 


Lys Ser Thr Phe Ser Lys Lys Asn Gly Thr Arg Ser Pro Pro Arg Pro 
                565                 570                 575     


Ser Pro Gly Gly Leu His Tyr Ser Asp Glu Asp Ile Cys Asn Lys Tyr 
            580                 585                 590         


Asn Gly Ala Val Leu Thr Glu Ser Val Ser Leu Lys Glu Lys Ser Ala 
        595                 600                 605             


Asp Ala Ser Glu Ser Glu Ala Thr Asp Ser Asp Tyr Glu Asp Ala Leu 
    610                 615                 620                 


Pro Lys His Ser Phe Val Asn His Tyr Met Ser Asp Pro Thr Tyr Tyr 
625                 630                 635                 640 


Asn Ser Trp Lys Arg Arg Ala Gln Gly Arg Ala Pro Ala Pro His Ser 
                645                 650                 655     


Val Ala Ile Leu Leu Thr Ser Asn Pro Ser Ala Tyr Leu Ser Val Ala 
            660                 665                 670         


Pro Arg Gly Ser Ala Ser Trp 
        675                 


<210>  191
<211>  2213
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Ala Arg Gly Ala Arg Pro Ser Ala Ala Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ala Glu Pro Pro Glu Arg Ala Gly Pro Gly Arg Pro Arg Gly Ser Pro 
            20                  25                  30          


Pro Gly Arg Ala Arg Pro Ser Leu Ala Pro Arg Pro Gly Pro Glu Pro 
        35                  40                  45              


Ser Arg Pro Arg Ala Ala Pro Glu Thr Ser Gly Gly Asp Thr Ala Gly 
    50                  55                  60                  


Ala Gly Arg Cys Gly Gly Arg Arg Ala Ala Lys Leu Gly Pro Gly Arg 
65                  70                  75                  80  


Arg Gly Trp Trp Ala Leu Leu Ala Leu Gln Leu His Leu Leu Arg Ala 
                85                  90                  95      


Leu Ala Gln Asp Asp Val Ala Pro Tyr Phe Lys Thr Glu Pro Gly Leu 
            100                 105                 110         


Pro Gln Ile His Leu Glu Gly Asn Arg Leu Val Leu Thr Cys Leu Ala 
        115                 120                 125             


Glu Gly Ser Trp Pro Leu Glu Phe Lys Trp Met Arg Asp Asp Ser Glu 
    130                 135                 140                 


Leu Thr Thr Tyr Ser Ser Glu Tyr Lys Tyr Ile Ile Pro Ser Leu Gln 
145                 150                 155                 160 


Lys Leu Asp Ala Gly Phe Tyr Arg Cys Val Val Arg Asn Arg Met Gly 
                165                 170                 175     


Ala Leu Leu Gln Arg Lys Ser Glu Val Gln Val Ala Tyr Met Gly Ser 
            180                 185                 190         


Phe Met Asp Thr Asp Gln Arg Lys Thr Val Ser Gln Gly Arg Ala Ala 
        195                 200                 205             


Ile Leu Asn Leu Leu Pro Ile Thr Ser Tyr Pro Arg Pro Gln Val Thr 
    210                 215                 220                 


Trp Phe Arg Glu Gly His Lys Ile Ile Pro Ser Asn Arg Ile Ala Ile 
225                 230                 235                 240 


Thr Leu Glu Asn Gln Leu Val Ile Leu Ala Thr Thr Thr Ser Asp Ala 
                245                 250                 255     


Gly Ala Tyr Tyr Val Gln Ala Val Asn Glu Lys Asn Gly Glu Asn Lys 
            260                 265                 270         


Thr Ser Pro Phe Ile His Leu Ser Ile Ala Arg Asp Val Gly Thr Pro 
        275                 280                 285             


Glu Thr Met Ala Pro Thr Ile Val Val Pro Pro Gly Asn Arg Ser Val 
    290                 295                 300                 


Val Ala Gly Ser Ser Glu Thr Thr Leu Glu Cys Ile Ala Ser Ala Arg 
305                 310                 315                 320 


Pro Val Glu Asp Leu Ser Val Thr Trp Lys Arg Asn Gly Val Arg Ile 
                325                 330                 335     


Thr Ser Gly Leu His Ser Phe Gly Arg Arg Leu Thr Ile Ser Asn Pro 
            340                 345                 350         


Thr Ser Ala Asp Thr Gly Pro Tyr Val Cys Glu Ala Ala Leu Pro Gly 
        355                 360                 365             


Ser Ala Phe Glu Pro Ala Arg Ala Thr Ala Phe Leu Phe Ile Ile Glu 
    370                 375                 380                 


Pro Pro Tyr Phe Thr Ala Glu Pro Glu Ser Arg Ile Ser Ala Glu Val 
385                 390                 395                 400 


Glu Glu Thr Val Asp Ile Gly Cys Gln Ala Met Gly Val Pro Leu Pro 
                405                 410                 415     


Thr Leu Gln Trp Tyr Lys Asp Ala Ile Ser Ile Ser Arg Leu Gln Asn 
            420                 425                 430         


Pro Arg Tyr Lys Val Leu Ala Ser Gly Gly Leu Arg Ile Gln Lys Leu 
        435                 440                 445             


Arg Pro Glu Asp Ser Gly Ile Phe Gln Cys Phe Ala Ser Asn Glu Gly 
    450                 455                 460                 


Gly Glu Ile Gln Thr His Thr Tyr Leu Asp Val Thr Asn Ile Ala Pro 
465                 470                 475                 480 


Val Phe Thr Gln Arg Pro Val Asp Thr Thr Val Thr Asp Gly Met Thr 
                485                 490                 495     


Ala Ile Leu Arg Cys Glu Val Ser Gly Ala Pro Lys Pro Ala Ile Thr 
            500                 505                 510         


Trp Lys Arg Glu Asn His Ile Leu Ala Ser Gly Ser Val Arg Ile Pro 
        515                 520                 525             


Arg Phe Met Leu Leu Glu Ser Gly Gly Leu Gln Ile Ala Pro Val Phe 
    530                 535                 540                 


Ile Gln Asp Ala Gly Asn Tyr Thr Cys Tyr Ala Ala Asn Thr Glu Gly 
545                 550                 555                 560 


Ser Leu Asn Ala Ser Ala Thr Leu Thr Val Trp Asn Arg Thr Ser Ile 
                565                 570                 575     


Val His Pro Pro Glu Asp His Val Val Ile Lys Gly Thr Thr Ala Thr 
            580                 585                 590         


Leu His Cys Gly Ala Thr His Asp Pro Arg Val Ser Leu Arg Tyr Val 
        595                 600                 605             


Trp Lys Lys Asp Asn Val Ala Leu Thr Pro Ser Ser Thr Ser Arg Ile 
    610                 615                 620                 


Val Val Glu Lys Asp Gly Ser Leu Leu Ile Ser Gln Thr Trp Ser Gly 
625                 630                 635                 640 


Asp Ile Gly Asp Tyr Ser Cys Glu Ile Val Ser Glu Gly Gly Asn Asp 
                645                 650                 655     


Ser Arg Met Ala Arg Leu Glu Val Ile Glu Leu Pro His Ser Pro Gln 
            660                 665                 670         


Asn Leu Leu Val Ser Pro Asn Ser Ser His Ser His Ala Val Val Leu 
        675                 680                 685             


Ser Trp Val Arg Pro Phe Asp Gly Asn Ser Pro Ile Leu Tyr Tyr Ile 
    690                 695                 700                 


Val Glu Leu Ser Glu Asn Asn Ser Pro Trp Lys Val His Leu Ser Asn 
705                 710                 715                 720 


Val Gly Pro Glu Met Thr Gly Val Thr Val Ser Gly Leu Thr Pro Ala 
                725                 730                 735     


Arg Thr Tyr Gln Phe Arg Val Cys Ala Val Asn Glu Val Gly Arg Gly 
            740                 745                 750         


Gln Tyr Ser Ala Glu Thr Ser Arg Leu Met Leu Pro Glu Glu Pro Pro 
        755                 760                 765             


Ser Ala Pro Pro Lys Asn Ile Val Ala Ser Gly Arg Thr Asn Gln Ser 
    770                 775                 780                 


Ile Met Val Gln Trp Gln Pro Pro Pro Glu Thr Glu His Asn Gly Val 
785                 790                 795                 800 


Leu Arg Gly Tyr Ile Leu Arg Tyr Arg Leu Ala Gly Leu Pro Gly Glu 
                805                 810                 815     


Tyr Gln Gln Arg Asn Ile Thr Ser Pro Glu Val Asn Tyr Cys Leu Val 
            820                 825                 830         


Thr Asp Leu Ile Ile Trp Thr Gln Tyr Glu Ile Gln Val Ala Ala Tyr 
        835                 840                 845             


Asn Gly Ala Gly Leu Gly Val Phe Ser Arg Ala Val Thr Glu Tyr Thr 
    850                 855                 860                 


Leu Gln Gly Val Pro Thr Ala Pro Pro Gln Asn Val Gln Thr Glu Ala 
865                 870                 875                 880 


Val Asn Ser Thr Thr Ile Gln Phe Leu Trp Asn Pro Pro Pro Gln Gln 
                885                 890                 895     


Phe Ile Asn Gly Ile Asn Gln Gly Tyr Lys Leu Leu Ala Trp Pro Ala 
            900                 905                 910         


Asp Ala Pro Glu Ala Val Thr Val Val Thr Ile Ala Pro Asp Phe His 
        915                 920                 925             


Gly Val His His Gly His Ile Thr Asn Leu Lys Lys Phe Thr Ala Tyr 
    930                 935                 940                 


Phe Thr Ser Val Leu Cys Phe Thr Thr Pro Gly Asp Gly Pro Pro Ser 
945                 950                 955                 960 


Thr Pro Gln Leu Val Trp Thr Gln Glu Asp Lys Pro Gly Ala Val Gly 
                965                 970                 975     


His Leu Ser Phe Thr Glu Ile Leu Asp Thr Ser Leu Lys Val Ser Trp 
            980                 985                 990         


Gln Glu Pro Leu Glu Lys Asn Gly  Ile Ile Thr Gly Tyr  Gln Ile Ser 
        995                 1000                 1005             


Trp Glu  Val Tyr Gly Arg Asn  Asp Ser Arg Leu Thr  His Thr Leu 
    1010                 1015                 1020             


Asn Ser  Thr Thr His Glu Tyr  Lys Ile Gln Gly Leu  Ser Ser Leu 
    1025                 1030                 1035             


Thr Thr  Tyr Thr Ile Asp Val  Ala Ala Val Thr Ala  Val Gly Thr 
    1040                 1045                 1050             


Gly Leu  Val Thr Ser Ser Thr  Ile Ser Ser Gly Val  Pro Pro Asp 
    1055                 1060                 1065             


Leu Pro  Gly Ala Pro Ser Asn  Leu Val Ile Ser Asn  Ile Ser Pro 
    1070                 1075                 1080             


Arg Ser  Ala Thr Leu Gln Phe  Arg Pro Gly Tyr Asp  Gly Lys Thr 
    1085                 1090                 1095             


Ser Ile  Ser Arg Trp Ile Val  Glu Gly Gln Val Gly  Ala Ile Gly 
    1100                 1105                 1110             


Asp Glu  Glu Glu Trp Val Thr  Leu Tyr Glu Glu Glu  Asn Glu Pro 
    1115                 1120                 1125             


Asp Ala  Gln Met Leu Glu Ile  Pro Asn Leu Thr Pro  Tyr Thr His 
    1130                 1135                 1140             


Tyr Arg  Phe Arg Met Lys Gln  Val Asn Ile Val Gly  Pro Ser Pro 
    1145                 1150                 1155             


Tyr Ser  Pro Ser Ser Arg Val  Ile Gln Thr Leu Gln  Ala Pro Pro 
    1160                 1165                 1170             


Asp Val  Ala Pro Thr Ser Val  Thr Val Arg Thr Ala  Ser Glu Thr 
    1175                 1180                 1185             


Ser Leu  Arg Leu Arg Trp Val  Pro Leu Pro Asp Ser  Gln Tyr Asn 
    1190                 1195                 1200             


Gly Asn  Pro Glu Ser Val Gly  Tyr Arg Ile Lys Tyr  Trp Arg Ser 
    1205                 1210                 1215             


Asp Leu  Gln Ser Ser Ala Val  Ala Gln Val Val Ser  Asp Arg Leu 
    1220                 1225                 1230             


Glu Arg  Glu Phe Thr Ile Glu  Glu Leu Glu Glu Trp  Met Glu Tyr 
    1235                 1240                 1245             


Glu Leu  Gln Met Gln Ala Phe  Asn Ala Val Gly Ala  Gly Pro Trp 
    1250                 1255                 1260             


Ser Glu  Val Val Arg Gly Arg  Thr Arg Glu Ser Val  Pro Ser Ala 
    1265                 1270                 1275             


Ala Pro  Glu Asn Val Ser Ala  Glu Ala Val Ser Ser  Thr Gln Ile 
    1280                 1285                 1290             


Leu Leu  Thr Trp Thr Ser Val  Pro Glu Gln Asp Gln  Asn Gly Leu 
    1295                 1300                 1305             


Ile Leu  Gly Tyr Lys Ile Leu  Phe Arg Ala Lys Asp  Leu Asp Pro 
    1310                 1315                 1320             


Glu Pro  Arg Ser His Ile Val  Arg Gly Asn His Thr  Gln Ser Ala 
    1325                 1330                 1335             


Leu Leu  Ala Gly Leu Arg Lys  Phe Val Leu Tyr Glu  Leu Gln Val 
    1340                 1345                 1350             


Leu Ala  Phe Thr Arg Ile Gly  Asn Gly Val Pro Ser  Thr Pro Leu 
    1355                 1360                 1365             


Ile Leu  Glu Arg Thr Lys Asp  Asp Ala Pro Gly Pro  Pro Val Arg 
    1370                 1375                 1380             


Leu Val  Phe Pro Glu Val Arg  Leu Thr Ser Val Arg  Ile Val Trp 
    1385                 1390                 1395             


Gln Pro  Pro Glu Glu Pro Asn  Gly Ile Ile Leu Gly  Tyr Gln Ile 
    1400                 1405                 1410             


Ala Tyr  Arg Leu Ala Ser Ser  Ser Pro His Thr Phe  Thr Thr Val 
    1415                 1420                 1425             


Glu Val  Gly Ala Thr Val Arg  Gln Phe Thr Ala Thr  Asp Leu Ala 
    1430                 1435                 1440             


Pro Glu  Ser Ala Tyr Ile Phe  Arg Leu Ser Ala Lys  Thr Arg Gln 
    1445                 1450                 1455             


Gly Trp  Gly Glu Pro Leu Glu  Ala Thr Val Ile Thr  Thr Glu Lys 
    1460                 1465                 1470             


Arg Glu  Arg Pro Ala Pro Pro  Arg Glu Leu Leu Val  Pro Gln Ala 
    1475                 1480                 1485             


Glu Val  Thr Ala Arg Ser Leu  Arg Leu Gln Trp Val  Pro Gly Ser 
    1490                 1495                 1500             


Asp Gly  Ala Ser Pro Ile Arg  Tyr Phe Thr Met Gln  Val Arg Glu 
    1505                 1510                 1515             


Leu Pro  Arg Gly Glu Trp Gln  Thr Tyr Ser Ser Ser  Ile Ser His 
    1520                 1525                 1530             


Glu Ala  Thr Ala Cys Val Val  Asp Arg Leu Arg Pro  Phe Thr Ser 
    1535                 1540                 1545             


Tyr Lys  Leu Arg Leu Lys Ala  Thr Asn Asp Ile Gly  Asp Ser Asp 
    1550                 1555                 1560             


Phe Ser  Ser Glu Thr Glu Ala  Val Thr Thr Leu Gln  Asp Val Pro 
    1565                 1570                 1575             


Gly Glu  Pro Pro Gly Ser Val  Ser Ala Thr Pro His  Thr Thr Ser 
    1580                 1585                 1590             


Ser Val  Leu Ile Gln Trp Gln  Pro Pro Arg Asp Glu  Ser Leu Asn 
    1595                 1600                 1605             


Gly Leu  Leu Gln Gly Tyr Arg  Ile Tyr Tyr Arg Glu  Leu Glu Tyr 
    1610                 1615                 1620             


Glu Ala  Gly Ser Gly Thr Glu  Ala Lys Thr Leu Lys  Asn Pro Ile 
    1625                 1630                 1635             


Ala Leu  His Ala Glu Leu Thr  Ala Gln Ser Ser Phe  Lys Thr Val 
    1640                 1645                 1650             


Asn Ser  Ser Ser Thr Ser Thr  Met Cys Glu Leu Thr  His Leu Lys 
    1655                 1660                 1665             


Lys Tyr  Arg Arg Tyr Glu Val  Ile Met Thr Ala Tyr  Asn Ile Ile 
    1670                 1675                 1680             


Gly Glu  Ser Pro Ala Ser Ala  Pro Val Glu Val Phe  Val Gly Glu 
    1685                 1690                 1695             


Ala Ala  Pro Ala Met Ala Pro  Gln Asn Val Gln Val  Thr Pro Leu 
    1700                 1705                 1710             


Thr Ala  Ser Gln Leu Glu Val  Thr Trp Asp Pro Pro  Pro Pro Glu 
    1715                 1720                 1725             


Ser Gln  Asn Gly Asn Ile Gln  Gly Tyr Lys Ile Tyr  Tyr Trp Glu 
    1730                 1735                 1740             


Ala Asp  Ser Gln Asn Glu Thr  Glu Lys Met Lys Val  Leu Phe Leu 
    1745                 1750                 1755             


Pro Glu  Pro Val Val Arg Leu  Lys Asn Leu Thr Ser  His Thr Lys 
    1760                 1765                 1770             


Tyr Leu  Val Ser Ile Ser Ala  Phe Asn Ala Ala Gly  Asp Gly Pro 
    1775                 1780                 1785             


Lys Ser  Asp Pro Gln Gln Gly  Arg Thr His Gln Ala  Ala Pro Gly 
    1790                 1795                 1800             


Ala Pro  Ser Phe Leu Ala Phe  Ser Glu Ile Thr Ser  Thr Thr Leu 
    1805                 1810                 1815             


Asn Val  Ser Trp Gly Glu Pro  Ala Ala Ala Asn Gly  Ile Leu Gln 
    1820                 1825                 1830             


Gly Tyr  Arg Val Val Tyr Glu  Pro Leu Ala Pro Val  Gln Gly Val 
    1835                 1840                 1845             


Ser Lys  Val Val Thr Val Glu  Val Arg Gly Asn Trp  Gln Arg Trp 
    1850                 1855                 1860             


Leu Lys  Val Arg Asp Leu Thr  Lys Gly Val Thr Tyr  Phe Phe Arg 
    1865                 1870                 1875             


Val Gln  Ala Arg Thr Ile Thr  Tyr Gly Pro Glu Leu  Gln Ala Asn 
    1880                 1885                 1890             


Ile Thr  Ala Gly Pro Ala Glu  Gly Ser Pro Gly Ser  Pro Arg Asp 
    1895                 1900                 1905             


Val Leu  Val Thr Lys Ser Ala  Ser Glu Leu Thr Leu  Gln Trp Thr 
    1910                 1915                 1920             


Glu Gly  His Ser Gly Asp Thr  Pro Thr Thr Gly Tyr  Val Ile Glu 
    1925                 1930                 1935             


Ala Arg  Pro Ser Asp Glu Gly  Leu Trp Asp Met Phe  Val Lys Asp 
    1940                 1945                 1950             


Ile Pro  Arg Ser Ala Thr Ser  Tyr Thr Leu Ser Leu  Asp Lys Leu 
    1955                 1960                 1965             


Arg Gln  Gly Val Thr Tyr Glu  Phe Arg Val Val Ala  Val Asn Glu 
    1970                 1975                 1980             


Ala Gly  Tyr Gly Glu Pro Ser  Asn Pro Ser Thr Ala  Val Ser Ala 
    1985                 1990                 1995             


Gln Val  Glu Ala Pro Phe Tyr  Glu Glu Trp Trp Phe  Leu Leu Val 
    2000                 2005                 2010             


Met Ala  Leu Ser Ser Leu Ile  Val Ile Leu Leu Val  Val Phe Ala 
    2015                 2020                 2025             


Leu Val  Leu His Gly Gln Asn  Lys Lys Tyr Lys Asn  Cys Ser Thr 
    2030                 2035                 2040             


Gly Lys  Gly Ile Ser Thr Met  Glu Glu Ser Val Thr  Leu Asp Asn 
    2045                 2050                 2055             


Gly Gly  Phe Ala Ala Leu Glu  Leu Ser Ser Arg His  Leu Asn Val 
    2060                 2065                 2070             


Lys Ser  Thr Phe Ser Lys Lys  Asn Gly Thr Arg Ser  Pro Pro Arg 
    2075                 2080                 2085             


Pro Ser  Pro Gly Gly Leu His  Tyr Ser Asp Glu Asp  Ile Cys Asn 
    2090                 2095                 2100             


Lys Tyr  Asn Gly Ala Val Leu  Thr Glu Ser Val Ser  Leu Lys Glu 
    2105                 2110                 2115             


Lys Ser  Ala Asp Ala Ser Glu  Ser Glu Ala Thr Asp  Ser Asp Tyr 
    2120                 2125                 2130             


Glu Asp  Ala Leu Pro Lys His  Ser Phe Val Asn His  Tyr Met Ser 
    2135                 2140                 2145             


Asp Pro  Thr Tyr Tyr Asn Ser  Trp Lys Arg Arg Ala  Gln Gly Arg 
    2150                 2155                 2160             


Ala Pro  Ala Pro His Arg Tyr  Glu Ala Val Ala Gly  Ser Glu Ala 
    2165                 2170                 2175             


Gly Ala  Gln Leu His Pro Val  Ile Thr Thr Gln Ser  Ala Gly Gly 
    2180                 2185                 2190             


Val Tyr  Thr Pro Ala Gly Pro  Gly Ala Arg Thr Pro  Leu Thr Gly 
    2195                 2200                 2205             


Phe Ser  Ser Phe Val 
    2210             


<210>  192
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  193
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  194
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  195
<211>  1541
<212>  DNA
<213>  Mus musculus

<400>  195
atggcaccct gcatgctgct cctgctgttg gcggccgccc tggccccgac tcagacccgc       60

gcgggcccac attcgctgag gtatttccac accgccgtgt cccggcccgg cctcgggaag      120

ccccggttca tctctgtcgg ctacgtggac gacacgcagt tcgtgcgctt cgacagcgac      180

gcggagaatc cgaggtatga gccgcgggtg cggtggatgg agcaggtgga gcccgagtat      240

tgggagcgga acacgcagat cgccaagggc aatgagcaga ttttccgagt gaacctgagg      300

accgcgctgc gctactacaa ccagagcgcg ggcggctctc acacgttcca acggatgtac      360

ggctgtgagg tggggtcgga ctggcgcctc ctccgcgggt acgagcagta cgcatacgac      420

ggctgcgatt acatcgccct gaacgaagac ctgaaaacgt ggacggcggc cgacatggcg      480

gcgctgatca ccaaacacaa gtgggagcag gctggtgatg cagagagaga ccgggcctac      540

ctggagggca cgtgcgtgga gtggctccgc agatacctgc agctcgggaa cgcgacgctg      600

ccgcgcacag attccccaaa ggcccatgtg acccgtcaca gcagacctga agataaagtc      660

accctgaggt gctgggccct gggcttctac cctgctgaca tcaccctgac ctggcagttg      720

aatggggagg agctgaccca ggacatggag cttgtggaga ccaggcctgc aggggatgga      780

accttccaga agtgggcatc tgtggtggtg cctcttggga aggagcagta ttacacatgc      840

catgtgtacc atcaggggct gcctgagccc ctcaccctga gatgggagcc tcctccatcc      900

actgtctcca acacggtaat cattgctgtt ctggttgtcc ttggagctgc aatagtcact      960

ggagctgtgg tggcttttgt gatgaagatg agaaggagaa acacaggtgg aaaaggaggg     1020

gactatgctc tggctccagg ctcccagacc tctgatctgt ctctcccaga ttgtaaagcg     1080

tgaagacagc tgcctggagt ggacttggtg acagacaatg tcttctcata tctcctgtga     1140

catccagagc cctcagttct ctttagtcaa gtgtctgatg ttacctgtga gcctatggac     1200

tcaatgtgaa gaactgtgga gcccagtcca cccctctaca ccaggaccct gtccctgcac     1260

tgctctgtct tcccttccac agccaacctt gctggttcag ccaaacactg agggacatct     1320

gtagcctgtc agctccatgc taccctgacc tgcaactcct cacttccaca ctgagaataa     1380

taatttgaat gtaaccttga ttgttatcat cttgacctag ggctgatttc ttgttaattt     1440

catggattga gaatgcttag aggttttgtt tgtttgtttg attgatttgt ttttttgaag     1500

aaataaatga tagatgaata aacttccaga atttgggtgc a                         1541


<210>  196
<211>  1540
<212>  DNA
<213>  Mus musculus

<400>  196
atggcaccct gcacgctgct cctgctgttg gcggccgccc tggcccccac tcagacccgc       60

gcgggcccac attcgctgag gtatttcgtc accgccgtgt cccggcccgg cctcggggag      120

ccccggttca tcgctgtcgg ctacgtggac gacacgcagt tcgtgcgctt cgacagcgac      180

gcggataatc cgagatttga gccgcgggcg ccgtggatgg agcaggaggg gccggagtat      240

tgggaggagc agacacagag agccaagagc gatgagcagt ggttccgagt gagcctgagg      300

accgcacaga gatactacaa ccagagcaag ggcggctctc acacgttcca gcggatgttc      360

ggctgtgacg tggggtcgga ctggcgcctc ctccgcgggt accagcagtt cgcctacgac      420

ggccgcgatt acatcgccct gaacgaagac ctgaaaacgt ggacggcggc ggacacggcg      480

gcgctgatca ccagacgcaa gtgggagcag gctggtgatg cagagtatta cagggcctac      540

ctagagggcg agtgcgtgga gtggctccgc agatacctgg agctcgggaa tgagacgctg      600

ctgcgcacag attccccaaa ggcccatgtg acctatcacc ccagatctca agttgatgtc      660

accctgaggt gctgggccct gggcttctac cctgctgata tcaccctgac ctggcagttg      720

aatggggagg acctgaccca ggacatggag cttgtagaga ccaggcctgc aggggatgga      780

accttccaga agtgggcagc tgtggtggtg cctcttggga aggagcagaa ttacacatgc      840

catgtgcacc ataaggggct gcctgagcct ctcaccctga gatggaagct tcctccatcc      900

actgtctcca acacggtaat cattgctgtt ctggttgtcc ttggagctgc aatagtcact      960

ggagctgtgg tggcttttgt gatgaagatg agaaggaaca caggtggaaa aggagtgaac     1020

tatgctctgg ctccaggctc ccagacctct gatctgtctc tcccagatgg taaagtgatg     1080

gttcatgacc ctcattctct agcgtgaaga cagctgcctg gagtggactt ggtgacagac     1140

aatgtcttca cacatctcct gtgacatcca gagccctcag ttctctttag tcaagtgtct     1200

gatgttccct gtgagcctat ggactcaaag tgaagaactg tggagcccag tccacccctc     1260

cacaccagca ccctgtccct gcactgctct gtcttccctt ccacagccaa ccttgctggt     1320

tcagccaaac actgggggac atctgcagcc tgtcagctcc atgctaccct gacctgcagc     1380

tcctcacttc cacactgaga atagtaattt gaatgtaacc ttgattgtta tcatcttgac     1440

ctagggctga tttcttgtta atttcatgct tagaggtttt gtttgtttgt ttgattgttt     1500

tttttttttg aagaaataaa tgatagatga ataaaccgca                           1540


<210>  197
<211>  2001
<212>  DNA
<213>  Mus musculus

<400>  197
attccagatg gggcaatggc actgggaagg ctgctcctgc tgctggcagc cgccctgacc       60

ctgaccaaaa ccggagcggg ctcacactcg ctgcggtatt tcgagacctc ggtgtcccag      120

cccggcttcg ggaagccccg gttcatctct gtcggctacg tggacgacac gcagtttgtg      180

cgcttcgaca gcgacgcgaa gaatccgaga tatgagctgc gggcgccgtg gatggagcag      240

gaggggccgg agtattggga gcggaacaca cggagagtca agggcagtga gaagagattc      300

caagagagcc tgagcaccct gctcagctac tacaaccaga gcaagggcgg cattcacacc      360

ttccagaagt tgtctggctg tgatctgggg tcagatgggc gccttcaaag cgggtacctg      420

cagttcgcct atgatggcct tgattacatc gccctgaatg aagacctgga aacctggaca      480

gcagcagatg tggcagctca ggaaacccga cacaagtggg agcaggctgg tgctgctgag      540

aaacacagga cctacctgga gggcaagtgc ctgatgtggc tccacagata cctggagctc      600

aggaaggaga tgctgctgcg cacagatccc ccaaaggcac atgtgactca tcaccccaga      660

tctcaaggtg atgtcaccct gaggtgctgg gccctgggct tctaccctgc tgacatcacc      720

ctgacctggc agttgaatgg ggaggagctg acccagcaca tggagcttgt ggagaccagg      780

cctgcagggg atggaacctt ccagaagtgg gcatctgtgg tggtgcctct tgggaaggag      840

cagaattaca catgccatgt gtaccatgag gggctgcctg agcccctcac cctgagatgg      900

gagcctcctc catacactgt ttccaacatg gtaatcatag ctgttctggt tgtccttgga      960

gctgtgatag tcattggagc tgtggtcatc attggagtta tggtgtcttt tgtgatgaag     1020

aggaggagaa acaaagcatg aagacagctg cctggagtag actgagtgat agccagtgtg     1080

ttcaggtctc tcctgtgaca tcaagagtct ttagacatca gctttcttta gaaaatggtg     1140

tctcatgttc tctgccacac caaccccagt agcagccatg tgacaagttg cacagactga     1200

ggtatacttc aaaagaagga ggcctcctgg accagttgtg gaactcttgg ccagagtatt     1260

atattgagtc ttagttctca tggcaattga tttattttgt tttctcttat tccttttctt     1320

atttacatgt tcctcgtaac ctaggctaag atctcatgtg aaagtaatgg gttagaaacc     1380

atccctagaa ttggggtcac taacatgacc ttatctgggg aaaccaacgc tttactttag     1440

aaattattta caaaattata taatagtatt acacagataa aaacttttcc aacaataaaa     1500

tttcatgtgg ctacatgtgt gttatcggag gtgggctttg gcatgtggta aagaaagtct     1560

taaataaaaa gaattaacat agtttaaatt taagcactga aaaaaatcag gcattagatg     1620

ttaaataata attgaccata aagatttatt aacatgtctt gaacatatgc cagtagcctt     1680

ggatgactgc cccactgctt atattctttt agagttgtta tacttcaatc atttctactc     1740

ttcatgatgt cacctgttct gtttgtgatt cactgaacac atctttacag aattgtaatg     1800

tttgcctgat ttttgtgctt tcctgtgcca aatgataatg atggtatttg tgattgcttc     1860

actggacaca tcttcaaagt gttgtaatat ttgctctttt aatgtttaaa aacccctgct     1920

tgagagctgc aaaatacact cggattcata ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaaa a                                               2001


