                         SEQUENCE LISTING

<110>  GRIFOLS DIAGNOSTIC SOLUTIONS INC.
 
<120>  COMPOSITION COMPRISING RECOMBINANT GpIba RECEPTOR 
       PROTEIN

<130>  62/632870

<150>  62/632870
<151>  2018-02-20

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  290
<212>  PRT
<213>  Synthetic

<400>  1

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  2
<211>  290
<212>  PRT
<213>  Synthetic

<400>  2

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Val Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  3
<211>  290
<212>  PRT
<213>  Synthetic

<400>  3

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Val Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  4
<211>  290
<212>  PRT
<213>  Synthetic

<400>  4

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  5
<211>  290
<212>  PRT
<213>  Synthetic

<400>  5

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Thr Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  6
<211>  290
<212>  PRT
<213>  Synthetic

<400>  6

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Val Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  7
<211>  290
<212>  PRT
<213>  Synthetic

<400>  7

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  8
<211>  290
<212>  PRT
<213>  Synthetic

<400>  8

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Val Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  9
<211>  278
<212>  PRT
<213>  Synthetic

<400>  9

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp 
225                 230                 235                 240 


Lys Phe Pro Val Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly 
                245                 250                 255     


Asp Glu Gly Asp Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr 
            260                 265                 270         


Glu Gly Asp Lys Val Arg 
        275             


<210>  10
<211>  40
<212>  PRT
<213>  Synthetic

<400>  10

Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
1               5                   10                  15      


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            20                  25                  30          


Ala Gln Ala Gly Lys Glu Pro Gly 
        35                  40  


<210>  11
<211>  227
<212>  PRT
<213>  Synthetic

<400>  11

Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 


Pro Gly Ile 
225         


<210>  12
<211>  231
<212>  PRT
<213>  Synthetic

<400>  12

Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
1               5                   10                  15      


Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
            20                  25                  30          


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
    50                  55                  60                  


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
65                  70                  75                  80  


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
                85                  90                  95      


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
        115                 120                 125             


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
    130                 135                 140                 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
145                 150                 155                 160 


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
                165                 170                 175     


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
            180                 185                 190         


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
        195                 200                 205             


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
    210                 215                 220                 


Ser Phe Ser Arg Thr Pro Gly 
225                 230     


<210>  13
<211>  27
<212>  PRT
<213>  Synthetic

<400>  13

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  14
<211>  94
<212>  PRT
<213>  Synthetic

<400>  14

Gly Ser His Met Trp Lys Gln Ser Val Glu Leu Ala Lys Lys Asp Ser 
1               5                   10                  15      


Leu Tyr Lys Asp Ala Met Gln Tyr Ala Ser Glu Ser Lys Asp Thr Glu 
            20                  25                  30          


Leu Ala Glu Glu Leu Leu Gln Trp Phe Leu Gln Glu Glu Lys Arg Glu 
        35                  40                  45              


Cys Phe Gly Ala Cys Leu Phe Thr Cys Tyr Asp Leu Leu Arg Pro Asp 
    50                  55                  60                  


Val Val Leu Glu Leu Ala Trp Arg His Asn Ile Met Asp Phe Ala Met 
65                  70                  75                  80  


Pro Tyr Phe Ile Gln Val Met Lys Glu Tyr Leu Thr Lys Val 
                85                  90                  


<210>  15
<211>  6
<212>  PRT
<213>  Synthetic

<400>  15

His His His His His His 
1               5       


<210>  16
<211>  7
<212>  PRT
<213>  Synthetic

<400>  16

His His His His His His Cys 
1               5           


<210>  17
<211>  21
<212>  PRT
<213>  Synthetic

<400>  17

Glu Glu Ala Ala Glu Glu Glu Ala Ala Glu Glu Ser Asp Asp Asp His 
1               5                   10                  15      


His His His His His 
            20      


<210>  18
<211>  44
<212>  PRT
<213>  Synthetic

<400>  18

Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro His His His His His His 
        35                  40                  


<210>  19
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  19

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  20
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ser 
            20                  25  


<210>  21
<211>  526
<212>  PRT
<213>  Synthetic

<400>  21

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
    290                 295                 300                 


Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
305                 310                 315                 320 


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
                325                 330                 335     


Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
            340                 345                 350         


Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
        355                 360                 365             


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
                405                 410                 415     


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
            420                 425                 430         


Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
        435                 440                 445             


Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    450                 455                 460                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
465                 470                 475                 480 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                485                 490                 495     


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
            500                 505                 510         


His Ser Pro Gly Ile Gly His His His His His His His His 
        515                 520                 525     


<210>  22
<211>  336
<212>  PRT
<213>  Synthetic

<400>  22

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly 
    290                 295                 300                 


Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu 
305                 310                 315                 320 


Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly His His His His His His 
                325                 330                 335     


<210>  23
<211>  336
<212>  PRT
<213>  Synthetic

<400>  23

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Val Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly 
    290                 295                 300                 


Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu 
305                 310                 315                 320 


Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly His His His His His His 
                325                 330                 335     


<210>  24
<211>  297
<212>  PRT
<213>  Synthetic

<400>  24

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg His His His His His His Cys 
    290                 295         


<210>  25
<211>  334
<212>  PRT
<213>  Synthetic

<400>  25

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val 
    290                 295                 300                 


Glu Gly Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His 
305                 310                 315                 320 


His Pro Gln Gly Gln Arg Glu Pro His His His His His His 
                325                 330                 


<210>  26
<211>  336
<212>  PRT
<213>  Synthetic

<400>  26

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ala Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Val Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly 
    290                 295                 300                 


Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu 
305                 310                 315                 320 


Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly His His His His His His 
                325                 330                 335     


<210>  27
<211>  296
<212>  PRT
<213>  Synthetic

<400>  27

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ala Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Val Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg His His His His His His 
    290                 295     


<210>  28
<211>  308
<212>  PRT
<213>  Synthetic

<400>  28

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ala Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Val Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Glu 
        275                 280                 285             


Glu Ala Ala Glu Glu Glu Ala Ala Glu Glu Ser Asp Asp Asp His His 
    290                 295                 300                 


His His His His 
305             


<210>  29
<211>  313
<212>  PRT
<213>  Synthetic

<400>  29

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Val Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Asp Tyr Lys 
        275                 280                 285             


Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp 
    290                 295                 300                 


Asp Asp Lys His His His His His His 
305                 310             


<210>  30
<211>  526
<212>  PRT
<213>  Synthetic

<400>  30

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Val Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
    290                 295                 300                 


Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
305                 310                 315                 320 


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
                325                 330                 335     


Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
            340                 345                 350         


Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
        355                 360                 365             


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
                405                 410                 415     


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
            420                 425                 430         


Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
        435                 440                 445             


Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    450                 455                 460                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
465                 470                 475                 480 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                485                 490                 495     


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
            500                 505                 510         


His Ser Pro Gly Ile Gly His His His His His His His His 
        515                 520                 525     


<210>  31
<211>  526
<212>  PRT
<213>  Synthetic

<400>  31

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Val Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
    290                 295                 300                 


Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
305                 310                 315                 320 


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
                325                 330                 335     


Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
            340                 345                 350         


Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
        355                 360                 365             


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
                405                 410                 415     


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
            420                 425                 430         


Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
        435                 440                 445             


Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    450                 455                 460                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
465                 470                 475                 480 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                485                 490                 495     


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
            500                 505                 510         


His Ser Pro Gly Ile Gly His His His His His His His His 
        515                 520                 525     


<210>  32
<211>  526
<212>  PRT
<213>  Synthetic

<400>  32

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
    290                 295                 300                 


Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
305                 310                 315                 320 


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
                325                 330                 335     


Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
            340                 345                 350         


Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
        355                 360                 365             


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
                405                 410                 415     


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
            420                 425                 430         


Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
        435                 440                 445             


Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    450                 455                 460                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
465                 470                 475                 480 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                485                 490                 495     


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
            500                 505                 510         


His Ser Pro Gly Ile Gly His His His His His His His His 
        515                 520                 525     


<210>  33
<211>  526
<212>  PRT
<213>  Synthetic

<400>  33

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Thr Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
    290                 295                 300                 


Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
305                 310                 315                 320 


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
                325                 330                 335     


Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
            340                 345                 350         


Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
        355                 360                 365             


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
                405                 410                 415     


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
            420                 425                 430         


Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
        435                 440                 445             


Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    450                 455                 460                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
465                 470                 475                 480 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                485                 490                 495     


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
            500                 505                 510         


His Ser Pro Gly Ile Gly His His His His His His His His 
        515                 520                 525     


<210>  34
<211>  526
<212>  PRT
<213>  Synthetic

<400>  34

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Val Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
    290                 295                 300                 


Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
305                 310                 315                 320 


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
                325                 330                 335     


Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
            340                 345                 350         


Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
        355                 360                 365             


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
                405                 410                 415     


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
            420                 425                 430         


Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
        435                 440                 445             


Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    450                 455                 460                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
465                 470                 475                 480 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                485                 490                 495     


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
            500                 505                 510         


His Ser Pro Gly Ile Gly His His His His His His His His 
        515                 520                 525     


<210>  35
<211>  296
<212>  PRT
<213>  Synthetic

<400>  35

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Val Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg His His His His His His 
    290                 295     


<210>  36
<211>  526
<212>  PRT
<213>  Synthetic

<400>  36

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Val Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
    290                 295                 300                 


Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
305                 310                 315                 320 


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
                325                 330                 335     


Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
            340                 345                 350         


Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
        355                 360                 365             


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
                405                 410                 415     


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
            420                 425                 430         


Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
        435                 440                 445             


Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    450                 455                 460                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
465                 470                 475                 480 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                485                 490                 495     


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
            500                 505                 510         


His Ser Pro Gly Ile Gly His His His His His His His His 
        515                 520                 525     


<210>  37
<211>  526
<212>  PRT
<213>  Synthetic

<400>  37

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
    290                 295                 300                 


Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
305                 310                 315                 320 


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
                325                 330                 335     


Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
            340                 345                 350         


Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
        355                 360                 365             


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
                405                 410                 415     


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
            420                 425                 430         


Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
        435                 440                 445             


Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    450                 455                 460                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
465                 470                 475                 480 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                485                 490                 495     


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
            500                 505                 510         


His Ser Pro Gly Ile Gly His His His His His His His His 
        515                 520                 525     


<210>  38
<211>  514
<212>  PRT
<213>  Synthetic

<400>  38

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp 
225                 230                 235                 240 


Lys Phe Pro Val Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly 
                245                 250                 255     


Asp Glu Gly Asp Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr 
            260                 265                 270         


Glu Gly Asp Lys Val Arg Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
        275                 280                 285             


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
                325                 330                 335     


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
            340                 345                 350         


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
    370                 375                 380                 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
385                 390                 395                 400 


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
                405                 410                 415     


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
            420                 425                 430         


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
        435                 440                 445             


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
    450                 455                 460                 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
465                 470                 475                 480 


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
                485                 490                 495     


Lys Ser Leu Ser His Ser Pro Gly Ile Gly His His His His His His 
            500                 505                 510         


His His 
        


<210>  39
<211>  529
<212>  PRT
<213>  Synthetic

<400>  39

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
    290                 295                 300                 


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
305                 310                 315                 320 


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
                325                 330                 335     


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
            340                 345                 350         


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
        355                 360                 365             


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
    370                 375                 380                 


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
385                 390                 395                 400 


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
                405                 410                 415     


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
            420                 425                 430         


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
        435                 440                 445             


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
    450                 455                 460                 


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
465                 470                 475                 480 


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
                485                 490                 495     


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
            500                 505                 510         


Thr Lys Ser Phe Ser Arg Thr Pro Gly His His His His His His His 
        515                 520                 525             


His 
    


<210>  40
<211>  323
<212>  PRT
<213>  Synthetic

<400>  40

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
    290                 295                 300                 


Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu His His His 
305                 310                 315                 320 


His His His 
            


<210>  41
<211>  390
<212>  PRT
<213>  Synthetic

<400>  41

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ser Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Thr Val Asp Val Lys Ala Met Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg Gly Ser His Met Trp Lys Gln Ser Val Glu Leu Ala Lys Lys 
    290                 295                 300                 


Asp Ser Leu Tyr Lys Asp Ala Met Gln Tyr Ala Ser Glu Ser Lys Asp 
305                 310                 315                 320 


Thr Glu Leu Ala Glu Glu Leu Leu Gln Trp Phe Leu Gln Glu Glu Lys 
                325                 330                 335     


Arg Glu Cys Phe Gly Ala Cys Leu Phe Thr Cys Tyr Asp Leu Leu Arg 
            340                 345                 350         


Pro Asp Val Val Leu Glu Leu Ala Trp Arg His Asn Ile Met Asp Phe 
        355                 360                 365             


Ala Met Pro Tyr Phe Ile Gln Val Met Lys Glu Tyr Leu Thr Lys Val 
    370                 375                 380                 


His His His His His His 
385                 390 


<210>  42
<211>  290
<212>  PRT
<213>  Synthetic

<400>  42

His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
1               5                   10                  15      


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
            20                  25                  30          


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
        35                  40                  45              


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
    50                  55                  60                  


Ala Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
65                  70                  75                  80  


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
                85                  90                  95      


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
            100                 105                 110         


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
        115                 120                 125             


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
    130                 135                 140                 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
145                 150                 155                 160 


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
                165                 170                 175     


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
            180                 185                 190         


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
        195                 200                 205             


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
    210                 215                 220                 


Glu Asn Val Tyr Val Trp Lys Gln Val Val Asp Val Lys Ala Val Thr 
225                 230                 235                 240 


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
                245                 250                 255     


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
            260                 265                 270         


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
        275                 280                 285             


Val Arg 
    290 


<210>  43
<211>  8
<212>  PRT
<213>  Synthetic

<400>  43

His His His His His His His His 
1               5               


<210>  44
<211>  9
<212>  PRT
<213>  Synthetic

<400>  44

Gly His His His His His His His His 
1               5                   


<210>  45
<211>  27
<212>  PRT
<213>  Synthetic

<400>  45

Glu Glu Asp Thr Glu Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
1               5                   10                  15      


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25          


<210>  46
<211>  236
<212>  PRT
<213>  Synthetic

<400>  46

Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 


Pro Gly Ile Gly His His His His His His His His 
225                 230                 235     


