                         SEQUENCE LISTING

<110>  Georg-August-Universitt Gttingen Stiftung ffentlichen 
       Rechts, Universittsmedizin
 
<120>  Gentherapeutische Behandlung von Schwerhrigkeit

<130>  979-4 PCT

<150>  DE 10 2018 103 924.7
<151>  21. Februar 2018

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  1997
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg Gly Arg 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu Glu Ile 
    50                  55                  60                  


Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Ser Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Glu Lys 
    130                 135                 140                 


Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Ser 
145                 150                 155                 160 


Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe 
                165                 170                 175     


Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu Pro Gln 
            180                 185                 190         


Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu 
        195                 200                 205             


Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala 
    210                 215                 220                 


Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser Lys Pro 
225                 230                 235                 240 


Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val 
                245                 250                 255     


Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp 
            260                 265                 270         


Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met 
        275                 280                 285             


Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp 
    290                 295                 300                 


Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser 
305                 310                 315                 320 


Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser 
                325                 330                 335     


Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe 
            340                 345                 350         


His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ser Gly 
        355                 360                 365             


Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp 
    370                 375                 380                 


Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile 
385                 390                 395                 400 


Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp 
                405                 410                 415     


Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met 
            420                 425                 430         


Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn 
        435                 440                 445             


Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys 
    450                 455                 460                 


Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu 
465                 470                 475                 480 


Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys 
                485                 490                 495     


Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr 
            500                 505                 510         


His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe 
        515                 520                 525             


Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg 
    530                 535                 540                 


Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly 
545                 550                 555                 560 


Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala Val Glu 
                565                 570                 575     


Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln 
            580                 585                 590         


Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys Met Glu 
        595                 600                 605             


Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg 
    610                 615                 620                 


Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr 
625                 630                 635                 640 


Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg Pro Arg 
                645                 650                 655     


Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ala Ser 
            660                 665                 670         


Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser Ser Thr 
        675                 680                 685             


Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His Leu Pro 
    690                 695                 700                 


Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp 
705                 710                 715                 720 


Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp 
                725                 730                 735     


Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu 
            740                 745                 750         


Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser 
        755                 760                 765             


Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His 
    770                 775                 780                 


Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg 
785                 790                 795                 800 


Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val 
                805                 810                 815     


Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu 
            820                 825                 830         


Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp 
        835                 840                 845             


Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg 
    850                 855                 860                 


Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly 
865                 870                 875                 880 


Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys 
                885                 890                 895     


Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu 
            900                 905                 910         


Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly 
        915                 920                 925             


Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu 
    930                 935                 940                 


His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe 
945                 950                 955                 960 


Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp 
                965                 970                 975     


Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln 
            980                 985                 990         


Ser Gln Cys Thr Glu Val Leu Asn  Glu Thr Leu Cys Pro  Thr Trp Asp 
        995                 1000                 1005             


Gln Met  Leu Val Phe Asp Asn  Leu Glu Leu Tyr Gly  Glu Ala His 
    1010                 1015                 1020             


Glu Leu  Arg Asp Asp Pro Pro  Ile Ile Val Ile Glu  Ile Tyr Asp 
    1025                 1030                 1035             


Gln Asp  Ser Met Gly Lys Ala  Asp Phe Met Gly Arg  Thr Phe Ala 
    1040                 1045                 1050             


Lys Pro  Leu Val Lys Met Ala  Asp Glu Ala Tyr Cys  Pro Pro Arg 
    1055                 1060                 1065             


Phe Pro  Pro Gln Leu Glu Tyr  Tyr Gln Ile Tyr Arg  Gly Asn Ala 
    1070                 1075                 1080             


Thr Ala  Gly Asp Leu Leu Ala  Ala Phe Glu Leu Leu  Gln Ile Gly 
    1085                 1090                 1095             


Pro Ala  Gly Lys Ala Asp Leu  Pro Pro Ile Asn Gly  Pro Val Asp 
    1100                 1105                 1110             


Val Asp  Arg Gly Pro Ile Met  Pro Val Pro Met Gly  Ile Arg Pro 
    1115                 1120                 1125             


Val Leu  Ser Lys Tyr Arg Val  Glu Val Leu Phe Trp  Gly Leu Arg 
    1130                 1135                 1140             


Asp Leu  Lys Arg Val Asn Leu  Ala Gln Val Asp Arg  Pro Arg Val 
    1145                 1150                 1155             


Asp Ile  Glu Cys Ala Gly Lys  Gly Val Gln Ser Ser  Leu Ile His 
    1160                 1165                 1170             


Asn Tyr  Lys Lys Asn Pro Asn  Phe Asn Thr Leu Val  Lys Trp Phe 
    1175                 1180                 1185             


Glu Val  Asp Leu Pro Glu Asn  Glu Leu Leu His Pro  Pro Leu Asn 
    1190                 1195                 1200             


Ile Arg  Val Val Asp Cys Arg  Ala Phe Gly Arg Tyr  Thr Leu Val 
    1205                 1210                 1215             


Gly Ser  His Ala Val Ser Ser  Leu Arg Arg Phe Ile  Tyr Arg Pro 
    1220                 1225                 1230             


Pro Asp  Arg Ser Ala Pro Ser  Trp Asn Thr Thr Val  Arg Leu Leu 
    1235                 1240                 1245             


Arg Arg  Cys Arg Val Leu Cys  Asn Gly Gly Ser Ser  Ser His Ser 
    1250                 1255                 1260             


Thr Gly  Glu Val Val Val Thr  Met Glu Pro Glu Val  Pro Ile Lys 
    1265                 1270                 1275             


Lys Leu  Glu Thr Met Val Lys  Leu Asp Ala Thr Ser  Glu Ala Val 
    1280                 1285                 1290             


Val Lys  Val Asp Val Ala Glu  Glu Glu Lys Glu Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Thr Ala Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  Gln Glu Pro Ser Gly  Ile Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Val Asp  Asn Thr Glu Gly Leu  Lys Gly Ser 
    1355                 1360                 1365             


Met Lys  Gly Lys Glu Lys Ala  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Thr Gln Ser Ser Gly  Ser Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Pro Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Asn Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Ser Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Val Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Arg  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Thr  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Asp Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro Pro Gly Arg  Val Lys Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Leu Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Ala Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ala Phe Val  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ile Lys  Tyr Leu Ile Cys Thr  Arg Tyr Lys Trp Leu  Ile Ile Lys 
    1955                 1960                 1965             


Ile Val  Leu Ala Leu Leu Gly  Leu Leu Met Leu Gly  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Leu Pro Gly Tyr Met  Val Lys Lys Leu Leu  Gly Ala 
    1985                 1990                 1995         


<210>  2
<211>  5994
<212>  DNA
<213>  Homo sapiens

<400>  2
atggccttgc tcatccacct caagacagtc tcggagctgc ggggcagggg cgaccggatc       60

gccaaagtga ctttccgagg gcaatccttc tactctcggg tcctggagaa ctgtgaggat      120

gtggctgact ttgatgagac atttcggtgg ccggtggcca gcagcatcga cagaaatgag      180

atgctggaga ttcaggtttt caactacagc aaagtcttca gcaacaagct catcgggacc      240

ttccgcatgg tgctgcagaa ggtggtagag gagagccatg tggaggtgac tgacacgctg      300

attgatgaca acaatgctat catcaagacc agcctgtgcg tggaggtccg gtatcaggcc      360

actgacggca cagtgggctc ctgggacgat ggggacttcc tgggagatga gtctcttcaa      420

gaggaagaga aggacagcca agagacggat ggactgctcc caggctcccg gcccagctcc      480

cggcccccag gagagaagag cttccggaga gccgggagga gcgtgttctc cgccatgaag      540

ctcggcaaaa accggtctca caaggaggag ccccaaagac cagatgaacc ggcggtgctg      600

gagatggaag accttgacca tctggccatt cggctaggag atggactgga tcccgactcg      660

gtgtctctag cctcagtcac agctctcacc actaatgtct ccaacaagcg atctaagcca      720

gacattaaga tggagccaag tgctgggcgg cccatggatt accaggtcag catcacggtg      780

atcgaggccc ggcagctggt gggcttgaac atggaccctg tggtgtgcgt ggaggtgggt      840

gacgacaaga agtacacatc catgaaggag tccactaact gcccctatta caacgagtac      900

ttcgtcttcg acttccatgt ctctccggat gtcatgtttg acaagatcat caagatttcg      960

gtgattcact ccaagaacct gctgcgcagt ggcaccctgg tgggctcctt caaaatggac     1020

gtgggaaccg tgtactcgca gccagagcac cagttccatc acaagtgggc catcctgtct     1080

gaccccgatg acatctcctc ggggctgaag ggctacgtga agtgtgacgt tgccgtggtg     1140

ggcaaagggg acaacatcaa gacgccccac aaggccaatg agaccgacga agatgacatt     1200

gaggggaact tgctgctccc cgagggggtg ccccccgaac gccagtgggc ccggttctat     1260

gtgaaaattt accgagcaga ggggctgccc cgtatgaaca caagcctcat ggccaatgta     1320

aagaaggctt tcatcggtga aaacaaggac ctcgtggacc cctacgtgca agtcttcttt     1380

gctggccaga agggcaagac ttcagtgcag aagagcagct atgagcccct gtggaatgag     1440

caggtcgtct ttacagacct cttcccccca ctctgcaaac gcatgaaggt gcagatccga     1500

gactcggaca aggtcaacga cgtggccatc ggcacccact tcattgacct gcgcaagatt     1560

tctaatgacg gagacaaagg cttcctgccc acactgggcc cagcctgggt gaacatgtac     1620

ggctccacac gtaactacac gctgctggat gagcatcagg acctgaacga gggcctgggg     1680

gagggtgtgt ccttccgggc ccggctcctg ctgggcctgg ctgtggagat cgtagacacc     1740

tccaaccctg agctcaccag ctccacagag gtgcaggtgg agcaggccac gcccatctcg     1800

gagagctgtg caggtaaaat ggaagaattc tttctctttg gagccttcct ggaggcctca     1860

atgatcgacc ggagaaacgg agacaagccc atcacctttg aggtcaccat aggcaactat     1920

gggaacgaag ttgatggcct gtcccggccc cagcggcctc ggccccggaa ggagccgggg     1980

gatgaggaag aagtagacct gattcagaac gcaagtgatg acgaggccgg tgatgccggg     2040

gacctggcct cagtctcctc cactccacca atgcggcccc aggtcaccga caggaactac     2100

ttccatctgc cctacctgga gcgaaagccc tgcatctaca tcaagagctg gtggccggac     2160

cagcgccgcc gcctctacaa tgccaacatc atggaccaca ttgccgacaa gctggaagaa     2220

ggcctgaacg acatacagga gatgatcaaa acggagaagt cctaccctga gcgtcgcctg     2280

cggggcgtcc tggaggagct gagctgtggc tgctgccgct tcctctccct cgctgacaag     2340

gaccagggcc actcatcccg caccaggctt gaccgggagc gcctcaagtc ctgcatgagg     2400

gagctggaaa acatggggca gcaggccagg atgctgcggg cccaggtgaa gcggcacacg     2460

gtgcgggaca agctgaggct gtgccagaac ttcctgcaga agctgcgctt cctggcggac     2520

gagccccagc acagcattcc cgacatcttc atctggatga tgagcaacaa caagcgtgtc     2580

gcctatgccc gtgtgccctc caaggacctg ctcttctcca tcgtggagga ggagactggc     2640

aaggactgcg ccaaggtcaa gacgctcttc cttaagctgc cagggaagcg gggcttcggc     2700

tcggcaggct ggacagtgca ggccaaggtg gagctgtacc tgtggctggg cctcagcaaa     2760

cagcgcaagg agttcctgtg cggcctgccc tgtggcttcc aggaggtcaa ggcagcccag     2820

ggcctgggcc tgcatgcctt cccacccgtc agcctggtct acaccaagaa gcaggcgttc     2880

cagctccgag cgcacatgta ccaggcccgc agcctctttg ccgccgacag cagcggactc     2940

tcagacccct ttgcccgcgt cttcttcatc aatcagagtc agtgcacaga ggtgctgaat     3000

gagaccctgt gtcccacctg ggaccagatg ctggtgttcg acaacctgga gctctatggt     3060

gaagctcatg agctgaggga cgatccgccc atcattgtca ttgaaatcta tgaccaggat     3120

tccatgggca aagctgactt catgggccgg accttcgcca aacccctggt gaagatggca     3180

gacgaggcgt actgcccacc ccgcttccca cctcagctcg agtactacca gatctaccgt     3240

ggcaacgcca cagctggaga cctgctggcg gccttcgagc tgctgcagat tggaccagca     3300

gggaaggctg acctgccccc catcaatggc ccggtggacg tggaccgagg tcccatcatg     3360

cccgtgccca tgggcatccg gcccgtgctc agcaagtacc gagtggaggt gctgttctgg     3420

ggcctacggg acctaaagcg ggtgaacctg gcccaggtgg accggccacg ggtggacatc     3480

gagtgtgcag ggaagggggt gcagtcgtcc ctgatccaca attataagaa gaaccccaac     3540

ttcaacaccc tcgtcaagtg gtttgaagtg gacctcccag agaacgagct gctgcacccg     3600

cccttgaaca tccgtgtggt ggactgccgg gccttcggtc gctacacact ggtgggctcc     3660

catgccgtca gctccctgcg acgcttcatc taccggcccc cagaccgctc ggcccccagc     3720

tggaacacca cggtcaggct tctccggcgc tgccgtgtgc tgtgcaatgg gggctcctcc     3780

tctcactcca caggggaggt tgtggtgact atggagccag aggtacccat caagaaactg     3840

gagaccatgg tgaagctgga cgcgacttct gaagctgttg tcaaggtgga tgtggctgag     3900

gaggagaagg agaagaagaa gaagaagaag ggcactgcgg aggagccaga ggaggaggag     3960

ccagacgaga gcatgctgga ctggtggtcc aagtactttg cctccattga caccatgaag     4020

gagcaacttc gacaacaaga gccctctgga attgacttgg aggagaagga ggaagtggac     4080

aataccgagg gcctgaaggg gtcaatgaag ggcaaggaga aggcaagggc tgccaaagag     4140

gagaagaaga agaaaactca gagctctggc tctggccagg ggtccgaggc ccccgagaag     4200

aagaaaccca agattgatga gcttaaggta taccccaaag agctggagtc cgagtttgat     4260

aactttgagg actggctgca cactttcaac ttgcttcggg gcaagaccgg ggatgatgag     4320

gatggctcca ccgaggagga gcgcattgtg ggacgcttca agggctccct ctgcgtgtac     4380

aaagtgccac tcccagagga cgtgtcccgg gaagccggct acgactccac ctacggcatg     4440

ttccagggca tcccgagcaa tgaccccatc aatgtgctgg tccgagtcta tgtggtccgg     4500

gccacggacc tgcaccctgc tgacatcaac ggcaaagctg acccctacat cgccatccgg     4560

ctaggcaaga ctgacatccg cgacaaggag aactacatct ccaagcagct caaccctgtc     4620

tttgggaagt cctttgacat cgaggcctcc ttccccatgg aatccatgct gacggtggct     4680

gtgtatgact gggacctggt gggcactgat gacctcattg gggaaaccaa gatcgacctg     4740

gagaaccgct tctacagcaa gcaccgcgcc acctgcggca tcgcccagac ctactccaca     4800

catggctaca atatctggcg ggaccccatg aagcccagcc agatcctgac ccgcctctgc     4860

aaagacggca aagtggacgg cccccacttt gggccccctg ggagagtgaa ggtggccaac     4920

cgcgtcttca ctgggccctc tgagattgag gacgagaacg gtcagaggaa gcccacagac     4980

gagcatgtgg cgctgttggc cctgaggcac tgggaggaca tcccccgcgc aggctgccgc     5040

ctggtgccag agcatgtgga gacgaggccg ctgctcaacc ccgacaagcc gggcatcgag     5100

cagggccgcc tggagctgtg ggtggacatg ttccccatgg acatgccagc ccctgggacg     5160

cctctggaca tctcacctcg gaagcccaag aagtacgagc tgcgggtcat catctggaac     5220

acagatgagg tggtcttgga ggacgacgac ttcttcacag gggagaagtc cagtgacatc     5280

ttcgtgaggg ggtggctgaa gggccagcag gaggacaagc aggacacaga cgtccactac     5340

cactccctca ctggcgaggg caacttcaac tggcgctacc tgttcccctt cgactacctg     5400

gcggcggagg agaagatcgt catctccaag aaggagtcca tgttctcctg ggacgagacc     5460

gagtacaaga tccccgcgcg gctcaccctg cagatctggg atgcggacca cttctccgct     5520

gacgacttcc tgggggccat cgagctggac ctgaaccggt tcccgcgggg cgcaaagaca     5580

gccaagcagt gcaccatgga gatggccacc ggggaggtgg acgtgcccct cgtgtccatc     5640

ttcaagcaaa agcgcgtcaa aggctggtgg cccctcctgg cccgcaatga gaacgatgag     5700

tttgagctca cgggcaaggt ggaggctgag ctgcatttac tgacagcaga ggaggcagag     5760

aagaacccag tgggcctggc ccgcaatgaa cctgaccccc tagagaaacc caaccggccc     5820

gacacggcct tcgtctggtt cctcaaccct ctcaagtcca tcaagtacct catctgcacc     5880

cggtacaagt ggctcatcat caagatcgtg ctggcgctgt tggggctgct catgttgggg     5940

ctcttcctct acagcctccc tggctacatg gtcaaaaagc tccttggggc atga           5994


<210>  3
<211>  1997
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg Gly Arg 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu Glu Ile 
    50                  55                  60                  


Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Ser Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Glu Lys 
    130                 135                 140                 


Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Ser 
145                 150                 155                 160 


Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe 
                165                 170                 175     


Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu Pro Gln 
            180                 185                 190         


Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu 
        195                 200                 205             


Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala 
    210                 215                 220                 


Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser Lys Pro 
225                 230                 235                 240 


Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val 
                245                 250                 255     


Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp 
            260                 265                 270         


Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met 
        275                 280                 285             


Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp 
    290                 295                 300                 


Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser 
305                 310                 315                 320 


Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser 
                325                 330                 335     


Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe 
            340                 345                 350         


His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ser Gly 
        355                 360                 365             


Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp 
    370                 375                 380                 


Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile 
385                 390                 395                 400 


Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp 
                405                 410                 415     


Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met 
            420                 425                 430         


Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn 
        435                 440                 445             


Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys 
    450                 455                 460                 


Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu 
465                 470                 475                 480 


Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys 
                485                 490                 495     


Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr 
            500                 505                 510         


His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe 
        515                 520                 525             


Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg 
    530                 535                 540                 


Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly 
545                 550                 555                 560 


Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala Val Glu 
                565                 570                 575     


Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln 
            580                 585                 590         


Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys Met Glu 
        595                 600                 605             


Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg 
    610                 615                 620                 


Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr 
625                 630                 635                 640 


Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg Pro Arg 
                645                 650                 655     


Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ala Ser 
            660                 665                 670         


Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser Ser Thr 
        675                 680                 685             


Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His Leu Pro 
    690                 695                 700                 


Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp 
705                 710                 715                 720 


Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp 
                725                 730                 735     


Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu 
            740                 745                 750         


Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser 
        755                 760                 765             


Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His 
    770                 775                 780                 


Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg 
785                 790                 795                 800 


Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val 
                805                 810                 815     


Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu 
            820                 825                 830         


Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp 
        835                 840                 845             


Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg 
    850                 855                 860                 


Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly 
865                 870                 875                 880 


Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys 
                885                 890                 895     


Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu 
            900                 905                 910         


Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly 
        915                 920                 925             


Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu 
    930                 935                 940                 


His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe 
945                 950                 955                 960 


Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp 
                965                 970                 975     


Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln 
            980                 985                 990         


Ser Gln Cys Thr Glu Val Leu Asn  Glu Thr Leu Cys Pro  Thr Trp Asp 
        995                 1000                 1005             


Gln Met  Leu Val Phe Asp Asn  Leu Glu Leu Tyr Gly  Glu Ala His 
    1010                 1015                 1020             


Glu Leu  Arg Asp Asp Pro Pro  Ile Ile Val Ile Glu  Ile Tyr Asp 
    1025                 1030                 1035             


Gln Asp  Ser Met Gly Lys Ala  Asp Phe Met Gly Arg  Thr Phe Ala 
    1040                 1045                 1050             


Lys Pro  Leu Val Lys Met Ala  Asp Glu Ala Tyr Cys  Pro Pro Arg 
    1055                 1060                 1065             


Phe Pro  Pro Gln Leu Glu Tyr  Tyr Gln Ile Tyr Arg  Gly Asn Ala 
    1070                 1075                 1080             


Thr Ala  Gly Asp Leu Leu Ala  Ala Phe Glu Leu Leu  Gln Ile Gly 
    1085                 1090                 1095             


Pro Ala  Gly Lys Ala Asp Leu  Pro Pro Ile Asn Gly  Pro Val Asp 
    1100                 1105                 1110             


Val Asp  Arg Gly Pro Ile Met  Pro Val Pro Met Gly  Ile Arg Pro 
    1115                 1120                 1125             


Val Leu  Ser Lys Tyr Arg Val  Glu Val Leu Phe Trp  Gly Leu Arg 
    1130                 1135                 1140             


Asp Leu  Lys Arg Val Asn Leu  Ala Gln Val Asp Arg  Pro Arg Val 
    1145                 1150                 1155             


Asp Ile  Glu Cys Ala Gly Lys  Gly Val Gln Ser Ser  Leu Ile His 
    1160                 1165                 1170             


Asn Tyr  Lys Lys Asn Pro Asn  Phe Asn Thr Leu Val  Lys Trp Phe 
    1175                 1180                 1185             


Glu Val  Asp Leu Pro Glu Asn  Glu Leu Leu His Pro  Pro Leu Asn 
    1190                 1195                 1200             


Ile Arg  Val Val Asp Cys Arg  Ala Phe Gly Arg Tyr  Thr Leu Val 
    1205                 1210                 1215             


Gly Ser  His Ala Val Ser Ser  Leu Arg Arg Phe Ile  Tyr Arg Pro 
    1220                 1225                 1230             


Pro Asp  Arg Ser Ala Pro Ser  Trp Asn Thr Thr Val  Arg Leu Leu 
    1235                 1240                 1245             


Arg Arg  Cys Arg Val Leu Cys  Asn Gly Gly Ser Ser  Ser His Ser 
    1250                 1255                 1260             


Thr Gly  Glu Val Val Val Thr  Met Glu Pro Glu Val  Pro Ile Lys 
    1265                 1270                 1275             


Lys Leu  Glu Thr Met Val Lys  Leu Asp Ala Thr Ser  Glu Ala Val 
    1280                 1285                 1290             


Val Lys  Val Asp Val Ala Glu  Glu Glu Lys Glu Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Thr Ala Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  Gln Glu Pro Ser Gly  Ile Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Val Asp  Asn Thr Glu Gly Leu  Lys Gly Ser 
    1355                 1360                 1365             


Met Lys  Gly Lys Glu Lys Ala  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Thr Gln Ser Ser Gly  Ser Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Pro Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Asn Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Ser Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Val Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Arg  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Thr  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Asp Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro Pro Gly Arg  Val Lys Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Leu Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Ala Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys 
    1955                 1960                 1965             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Leu Leu Ala  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Val Pro Gly Tyr Leu  Val Lys Lys Ile Leu  Gly Ala 
    1985                 1990                 1995         


<210>  4
<211>  5994
<212>  DNA
<213>  Homo sapiens

<400>  4
atggccttgc tcatccacct caagacagtc tcggagctgc ggggcagggg cgaccggatc       60

gccaaagtga ctttccgagg gcaatccttc tactctcggg tcctggagaa ctgtgaggat      120

gtggctgact ttgatgagac atttcggtgg ccggtggcca gcagcatcga cagaaatgag      180

atgctggaga ttcaggtttt caactacagc aaagtcttca gcaacaagct catcgggacc      240

ttccgcatgg tgctgcagaa ggtggtagag gagagccatg tggaggtgac tgacacgctg      300

attgatgaca acaatgctat catcaagacc agcctgtgcg tggaggtccg gtatcaggcc      360

actgacggca cagtgggctc ctgggacgat ggggacttcc tgggagatga gtctcttcaa      420

gaggaagaga aggacagcca agagacggat ggactgctcc caggctcccg gcccagctcc      480

cggcccccag gagagaagag cttccggaga gccgggagga gcgtgttctc cgccatgaag      540

ctcggcaaaa accggtctca caaggaggag ccccaaagac cagatgaacc ggcggtgctg      600

gagatggaag accttgacca tctggccatt cggctaggag atggactgga tcccgactcg      660

gtgtctctag cctcagtcac agctctcacc actaatgtct ccaacaagcg atctaagcca      720

gacattaaga tggagccaag tgctgggcgg cccatggatt accaggtcag catcacggtg      780

atcgaggccc ggcagctggt gggcttgaac atggaccctg tggtgtgcgt ggaggtgggt      840

gacgacaaga agtacacatc catgaaggag tccactaact gcccctatta caacgagtac      900

ttcgtcttcg acttccatgt ctctccggat gtcatgtttg acaagatcat caagatttcg      960

gtgattcact ccaagaacct gctgcgcagt ggcaccctgg tgggctcctt caaaatggac     1020

gtgggaaccg tgtactcgca gccagagcac cagttccatc acaagtgggc catcctgtct     1080

gaccccgatg acatctcctc ggggctgaag ggctacgtga agtgtgacgt tgccgtggtg     1140

ggcaaagggg acaacatcaa gacgccccac aaggccaatg agaccgacga agatgacatt     1200

gaggggaact tgctgctccc cgagggggtg ccccccgaac gccagtgggc ccggttctat     1260

gtgaaaattt accgagcaga ggggctgccc cgtatgaaca caagcctcat ggccaatgta     1320

aagaaggctt tcatcggtga aaacaaggac ctcgtggacc cctacgtgca agtcttcttt     1380

gctggccaga agggcaagac ttcagtgcag aagagcagct atgagcccct gtggaatgag     1440

caggtcgtct ttacagacct cttcccccca ctctgcaaac gcatgaaggt gcagatccga     1500

gactcggaca aggtcaacga cgtggccatc ggcacccact tcattgacct gcgcaagatt     1560

tctaatgacg gagacaaagg cttcctgccc acactgggcc cagcctgggt gaacatgtac     1620

ggctccacac gtaactacac gctgctggat gagcatcagg acctgaacga gggcctgggg     1680

gagggtgtgt ccttccgggc ccggctcctg ctgggcctgg ctgtggagat cgtagacacc     1740

tccaaccctg agctcaccag ctccacagag gtgcaggtgg agcaggccac gcccatctcg     1800

gagagctgtg caggtaaaat ggaagaattc tttctctttg gagccttcct ggaggcctca     1860

atgatcgacc ggagaaacgg agacaagccc atcacctttg aggtcaccat aggcaactat     1920

gggaacgaag ttgatggcct gtcccggccc cagcggcctc ggccccggaa ggagccgggg     1980

gatgaggaag aagtagacct gattcagaac gcaagtgatg acgaggccgg tgatgccggg     2040

gacctggcct cagtctcctc cactccacca atgcggcccc aggtcaccga caggaactac     2100

ttccatctgc cctacctgga gcgaaagccc tgcatctaca tcaagagctg gtggccggac     2160

cagcgccgcc gcctctacaa tgccaacatc atggaccaca ttgccgacaa gctggaagaa     2220

ggcctgaacg acatacagga gatgatcaaa acggagaagt cctaccctga gcgtcgcctg     2280

cggggcgtcc tggaggagct gagctgtggc tgctgccgct tcctctccct cgctgacaag     2340

gaccagggcc actcatcccg caccaggctt gaccgggagc gcctcaagtc ctgcatgagg     2400

gagctggaaa acatggggca gcaggccagg atgctgcggg cccaggtgaa gcggcacacg     2460

gtgcgggaca agctgaggct gtgccagaac ttcctgcaga agctgcgctt cctggcggac     2520

gagccccagc acagcattcc cgacatcttc atctggatga tgagcaacaa caagcgtgtc     2580

gcctatgccc gtgtgccctc caaggacctg ctcttctcca tcgtggagga ggagactggc     2640

aaggactgcg ccaaggtcaa gacgctcttc cttaagctgc cagggaagcg gggcttcggc     2700

tcggcaggct ggacagtgca ggccaaggtg gagctgtacc tgtggctggg cctcagcaaa     2760

cagcgcaagg agttcctgtg cggcctgccc tgtggcttcc aggaggtcaa ggcagcccag     2820

ggcctgggcc tgcatgcctt cccacccgtc agcctggtct acaccaagaa gcaggcgttc     2880

cagctccgag cgcacatgta ccaggcccgc agcctctttg ccgccgacag cagcggactc     2940

tcagacccct ttgcccgcgt cttcttcatc aatcagagtc agtgcacaga ggtgctgaat     3000

gagaccctgt gtcccacctg ggaccagatg ctggtgttcg acaacctgga gctctatggt     3060

gaagctcatg agctgaggga cgatccgccc atcattgtca ttgaaatcta tgaccaggat     3120

tccatgggca aagctgactt catgggccgg accttcgcca aacccctggt gaagatggca     3180

gacgaggcgt actgcccacc ccgcttccca cctcagctcg agtactacca gatctaccgt     3240

ggcaacgcca cagctggaga cctgctggcg gccttcgagc tgctgcagat tggaccagca     3300

gggaaggctg acctgccccc catcaatggc ccggtggacg tggaccgagg tcccatcatg     3360

cccgtgccca tgggcatccg gcccgtgctc agcaagtacc gagtggaggt gctgttctgg     3420

ggcctacggg acctaaagcg ggtgaacctg gcccaggtgg accggccacg ggtggacatc     3480

gagtgtgcag ggaagggggt gcagtcgtcc ctgatccaca attataagaa gaaccccaac     3540

ttcaacaccc tcgtcaagtg gtttgaagtg gacctcccag agaacgagct gctgcacccg     3600

cccttgaaca tccgtgtggt ggactgccgg gccttcggtc gctacacact ggtgggctcc     3660

catgccgtca gctccctgcg acgcttcatc taccggcccc cagaccgctc ggcccccagc     3720

tggaacacca cggtcaggct tctccggcgc tgccgtgtgc tgtgcaatgg gggctcctcc     3780

tctcactcca caggggaggt tgtggtgact atggagccag aggtacccat caagaaactg     3840

gagaccatgg tgaagctgga cgcgacttct gaagctgttg tcaaggtgga tgtggctgag     3900

gaggagaagg agaagaagaa gaagaagaag ggcactgcgg aggagccaga ggaggaggag     3960

ccagacgaga gcatgctgga ctggtggtcc aagtactttg cctccattga caccatgaag     4020

gagcaacttc gacaacaaga gccctctgga attgacttgg aggagaagga ggaagtggac     4080

aataccgagg gcctgaaggg gtcaatgaag ggcaaggaga aggcaagggc tgccaaagag     4140

gagaagaaga agaaaactca gagctctggc tctggccagg ggtccgaggc ccccgagaag     4200

aagaaaccca agattgatga gcttaaggta taccccaaag agctggagtc cgagtttgat     4260

aactttgagg actggctgca cactttcaac ttgcttcggg gcaagaccgg ggatgatgag     4320

gatggctcca ccgaggagga gcgcattgtg ggacgcttca agggctccct ctgcgtgtac     4380

aaagtgccac tcccagagga cgtgtcccgg gaagccggct acgactccac ctacggcatg     4440

ttccagggca tcccgagcaa tgaccccatc aatgtgctgg tccgagtcta tgtggtccgg     4500

gccacggacc tgcaccctgc tgacatcaac ggcaaagctg acccctacat cgccatccgg     4560

ctaggcaaga ctgacatccg cgacaaggag aactacatct ccaagcagct caaccctgtc     4620

tttgggaagt cctttgacat cgaggcctcc ttccccatgg aatccatgct gacggtggct     4680

gtgtatgact gggacctggt gggcactgat gacctcattg gggaaaccaa gatcgacctg     4740

gagaaccgct tctacagcaa gcaccgcgcc acctgcggca tcgcccagac ctactccaca     4800

catggctaca atatctggcg ggaccccatg aagcccagcc agatcctgac ccgcctctgc     4860

aaagacggca aagtggacgg cccccacttt gggccccctg ggagagtgaa ggtggccaac     4920

cgcgtcttca ctgggccctc tgagattgag gacgagaacg gtcagaggaa gcccacagac     4980

gagcatgtgg cgctgttggc cctgaggcac tgggaggaca tcccccgcgc aggctgccgc     5040

ctggtgccag agcatgtgga gacgaggccg ctgctcaacc ccgacaagcc gggcatcgag     5100

cagggccgcc tggagctgtg ggtggacatg ttccccatgg acatgccagc ccctgggacg     5160

cctctggaca tctcacctcg gaagcccaag aagtacgagc tgcgggtcat catctggaac     5220

acagatgagg tggtcttgga ggacgacgac ttcttcacag gggagaagtc cagtgacatc     5280

ttcgtgaggg ggtggctgaa gggccagcag gaggacaagc aggacacaga cgtccactac     5340

cactccctca ctggcgaggg caacttcaac tggcgctacc tgttcccctt cgactacctg     5400

gcggcggagg agaagatcgt catctccaag aaggagtcca tgttctcctg ggacgagacc     5460

gagtacaaga tccccgcgcg gctcaccctg cagatctggg atgcggacca cttctccgct     5520

gacgacttcc tgggggccat cgagctggac ctgaaccggt tcccgcgggg cgcaaagaca     5580

gccaagcagt gcaccatgga gatggccacc ggggaggtgg acgtgcccct cgtgtccatc     5640

ttcaagcaaa agcgcgtcaa aggctggtgg cccctcctgg cccgcaatga gaacgatgag     5700

tttgagctca cgggcaaggt ggaggctgag ctgcatttac tgacagcaga ggaggcagag     5760

aagaacccag tgggcctggc ccgcaatgaa cctgaccccc tagagaaacc caaccggccc     5820

gacacgagct tcatctggtt cctgaaccct ctcaagtcgg ctcgctactt cttgtggcac     5880

acgtatcgct ggctgctcct caaactgttg ctgctcctgc tgctgctcct cctcctcgcc     5940

ctgttcctct actctgtgcc tggctacctg gtcaagaaaa tcctcggggc ctga           5994


<210>  5
<211>  1230
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ile Lys Thr Glu Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val 
1               5                   10                  15      


Leu Glu Glu Leu Ser Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp 
            20                  25                  30          


Lys Asp Gln Gly His Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu 
        35                  40                  45              


Lys Ser Cys Met Arg Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met 
    50                  55                  60                  


Leu Arg Ala Gln Val Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu 
65                  70                  75                  80  


Cys Gln Asn Phe Leu Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln 
                85                  90                  95      


His Ser Ile Pro Asp Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg 
            100                 105                 110         


Val Ala Tyr Ala Arg Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val 
        115                 120                 125             


Glu Glu Glu Thr Gly Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu 
    130                 135                 140                 


Lys Leu Pro Gly Lys Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln 
145                 150                 155                 160 


Ala Lys Val Glu Leu Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys 
                165                 170                 175     


Glu Phe Leu Cys Gly Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala 
            180                 185                 190         


Gln Gly Leu Gly Leu His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr 
        195                 200                 205             


Lys Lys Gln Ala Phe Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser 
    210                 215                 220                 


Leu Phe Ala Ala Asp Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val 
225                 230                 235                 240 


Phe Phe Ile Asn Gln Ser Gln Cys Thr Glu Val Leu Asn Glu Thr Leu 
                245                 250                 255     


Cys Pro Thr Trp Asp Gln Met Leu Val Phe Asp Asn Leu Glu Leu Tyr 
            260                 265                 270         


Gly Glu Ala His Glu Leu Arg Asp Asp Pro Pro Ile Ile Val Ile Glu 
        275                 280                 285             


Ile Tyr Asp Gln Asp Ser Met Gly Lys Ala Asp Phe Met Gly Arg Thr 
    290                 295                 300                 


Phe Ala Lys Pro Leu Val Lys Met Ala Asp Glu Ala Tyr Cys Pro Pro 
305                 310                 315                 320 


Arg Phe Pro Pro Gln Leu Glu Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala 
                325                 330                 335     


Thr Ala Gly Asp Leu Leu Ala Ala Phe Glu Leu Leu Gln Ile Gly Pro 
            340                 345                 350         


Ala Gly Lys Ala Asp Leu Pro Pro Ile Asn Gly Pro Val Asp Val Asp 
        355                 360                 365             


Arg Gly Pro Ile Met Pro Val Pro Met Gly Ile Arg Pro Val Leu Ser 
    370                 375                 380                 


Lys Tyr Arg Val Glu Val Leu Phe Trp Gly Leu Arg Asp Leu Lys Arg 
385                 390                 395                 400 


Val Asn Leu Ala Gln Val Asp Arg Pro Arg Val Asp Ile Glu Cys Ala 
                405                 410                 415     


Gly Lys Gly Val Gln Ser Ser Leu Ile His Asn Tyr Lys Lys Asn Pro 
            420                 425                 430         


Asn Phe Asn Thr Leu Val Lys Trp Phe Glu Val Asp Leu Pro Glu Asn 
        435                 440                 445             


Glu Leu Leu His Pro Pro Leu Asn Ile Arg Val Val Asp Cys Arg Ala 
    450                 455                 460                 


Phe Gly Arg Tyr Thr Leu Val Gly Ser His Ala Val Ser Ser Leu Arg 
465                 470                 475                 480 


Arg Phe Ile Tyr Arg Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr 
                485                 490                 495     


Thr Gly Glu Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys 
            500                 505                 510         


Leu Glu Thr Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys 
        515                 520                 525             


Val Asp Val Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly 
    530                 535                 540                 


Thr Ala Glu Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp 
545                 550                 555                 560 


Trp Trp Ser Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu 
                565                 570                 575     


Arg Gln Gln Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val 
            580                 585                 590         


Asp Asn Thr Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala 
        595                 600                 605             


Arg Ala Ala Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser 
    610                 615                 620                 


Gly Gln Gly Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu 
625                 630                 635                 640 


Leu Lys Val Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu 
                645                 650                 655     


Asp Trp Leu His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp 
            660                 665                 670         


Glu Asp Gly Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly 
        675                 680                 685             


Ser Leu Cys Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu 
    690                 695                 700                 


Ala Gly Tyr Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn 
705                 710                 715                 720 


Asp Pro Ile Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp 
                725                 730                 735     


Leu His Pro Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile 
            740                 745                 750         


Arg Leu Gly Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys 
        755                 760                 765             


Gln Leu Asn Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe 
    770                 775                 780                 


Pro Met Glu Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val 
785                 790                 795                 800 


Gly Thr Asp Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg 
                805                 810                 815     


Phe Tyr Ser Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser 
            820                 825                 830         


Thr His Gly Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile 
        835                 840                 845             


Leu Thr Arg Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly 
    850                 855                 860                 


Pro Pro Gly Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser 
865                 870                 875                 880 


Glu Ile Glu Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val 
                885                 890                 895     


Ala Leu Leu Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys 
            900                 905                 910         


Arg Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Leu Asn Pro Asp 
        915                 920                 925             


Lys Pro Gly Ile Glu Gln Gly Arg Leu Glu Leu Trp Val Asp Met Phe 
    930                 935                 940                 


Pro Met Asp Met Pro Ala Pro Gly Thr Pro Leu Asp Ile Ser Pro Arg 
945                 950                 955                 960 


Lys Pro Lys Lys Tyr Glu Leu Arg Val Ile Ile Trp Asn Thr Asp Glu 
                965                 970                 975     


Val Val Leu Glu Asp Asp Asp Phe Phe Thr Gly Glu Lys Ser Ser Asp 
            980                 985                 990         


Ile Phe Val Arg Gly Trp Leu Lys  Gly Gln Gln Glu Asp  Lys Gln Asp 
        995                 1000                 1005             


Thr Asp  Val His Tyr His Ser  Leu Thr Gly Glu Gly  Asn Phe Asn 
    1010                 1015                 1020             


Trp Arg  Tyr Leu Phe Pro Phe  Asp Tyr Leu Ala Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ile Val  Ile Ser Lys Lys Glu  Ser Met Phe Ser Trp  Asp Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Lys Ile Pro Ala Arg  Leu Thr Leu Gln Ile  Trp Asp Ala 
    1055                 1060                 1065             


Asp His  Phe Ser Ala Asp Asp  Phe Leu Gly Ala Ile  Glu Leu Asp 
    1070                 1075                 1080             


Leu Asn  Arg Phe Pro Arg Gly  Ala Lys Thr Ala Lys  Gln Cys Thr 
    1085                 1090                 1095             


Met Glu  Met Ala Thr Gly Glu  Val Asp Val Pro Leu  Val Ser Ile 
    1100                 1105                 1110             


Phe Lys  Gln Lys Arg Val Lys  Gly Trp Trp Pro Leu  Leu Ala Arg 
    1115                 1120                 1125             


Asn Glu  Asn Asp Glu Phe Glu  Leu Thr Gly Lys Val  Glu Ala Glu 
    1130                 1135                 1140             


Leu His  Leu Leu Thr Ala Glu  Glu Ala Glu Lys Asn  Pro Val Gly 
    1145                 1150                 1155             


Leu Ala  Arg Asn Glu Pro Asp  Pro Leu Glu Lys Pro  Asn Arg Pro 
    1160                 1165                 1170             


Asp Thr  Ser Phe Ile Trp Phe  Leu Asn Pro Leu Lys  Ser Ala Arg 
    1175                 1180                 1185             


Tyr Phe  Leu Trp His Thr Tyr  Arg Trp Leu Leu Leu  Lys Leu Leu 
    1190                 1195                 1200             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Ala Leu Phe  Leu Tyr Ser 
    1205                 1210                 1215             


Val Pro  Gly Tyr Leu Val Lys  Lys Ile Leu Gly Ala  
    1220                 1225                 1230 


<210>  6
<211>  3693
<212>  DNA
<213>  Homo sapiens

<400>  6
atgatcaaaa cggagaagtc ctaccctgag cgtcgcctgc ggggcgtcct ggaggagctg       60

agctgtggct gctgccgctt cctctccctc gctgacaagg accagggcca ctcatcccgc      120

accaggcttg accgggagcg cctcaagtcc tgcatgaggg agctggaaaa catggggcag      180

caggccagga tgctgcgggc ccaggtgaag cggcacacgg tgcgggacaa gctgaggctg      240

tgccagaact tcctgcagaa gctgcgcttc ctggcggacg agccccagca cagcattccc      300

gacatcttca tctggatgat gagcaacaac aagcgtgtcg cctatgcccg tgtgccctcc      360

aaggacctgc tcttctccat cgtggaggag gagactggca aggactgcgc caaggtcaag      420

acgctcttcc ttaagctgcc agggaagcgg ggcttcggct cggcaggctg gacagtgcag      480

gccaaggtgg agctgtacct gtggctgggc ctcagcaaac agcgcaagga gttcctgtgc      540

ggcctgccct gtggcttcca ggaggtcaag gcagcccagg gcctgggcct gcatgccttc      600

ccacccgtca gcctggtcta caccaagaag caggcgttcc agctccgagc gcacatgtac      660

caggcccgca gcctctttgc cgccgacagc agcggactct cagacccctt tgcccgcgtc      720

ttcttcatca atcagagtca gtgcacagag gtgctgaatg agaccctgtg tcccacctgg      780

gaccagatgc tggtgttcga caacctggag ctctatggtg aagctcatga gctgagggac      840

gatccgccca tcattgtcat tgaaatctat gaccaggatt ccatgggcaa agctgacttc      900

atgggccgga ccttcgccaa acccctggtg aagatggcag acgaggcgta ctgcccaccc      960

cgcttcccac ctcagctcga gtactaccag atctaccgtg gcaacgccac agctggagac     1020

ctgctggcgg ccttcgagct gctgcagatt ggaccagcag ggaaggctga cctgcccccc     1080

atcaatggcc cggtggacgt ggaccgaggt cccatcatgc ccgtgcccat gggcatccgg     1140

cccgtgctca gcaagtaccg agtggaggtg ctgttctggg gcctacggga cctaaagcgg     1200

gtgaacctgg cccaggtgga ccggccacgg gtggacatcg agtgtgcagg gaagggggtg     1260

cagtcgtccc tgatccacaa ttataagaag aaccccaact tcaacaccct cgtcaagtgg     1320

tttgaagtgg acctcccaga gaacgagctg ctgcacccgc ccttgaacat ccgtgtggtg     1380

gactgccggg ccttcggtcg ctacacactg gtgggctccc atgccgtcag ctccctgcga     1440

cgcttcatct accggccccc agaccgctcg gcccccagct ggaacaccac gggggaggtt     1500

gtggtgacta tggagccaga ggtacccatc aagaaactgg agaccatggt gaagctggac     1560

gcgacttctg aagctgttgt caaggtggat gtggctgagg aggagaagga gaagaagaag     1620

aagaagaagg gcactgcgga ggagccagag gaggaggagc cagacgagag catgctggac     1680

tggtggtcca agtactttgc ctccattgac accatgaagg agcaacttcg acaacaagag     1740

ccctctggaa ttgacttgga ggagaaggag gaagtggaca ataccgaggg cctgaagggg     1800

tcaatgaagg gcaaggagaa ggcaagggct gccaaagagg agaagaagaa gaaaactcag     1860

agctctggct ctggccaggg gtccgaggcc cccgagaaga agaaacccaa gattgatgag     1920

cttaaggtat accccaaaga gctggagtcc gagtttgata actttgagga ctggctgcac     1980

actttcaact tgcttcgggg caagaccggg gatgatgagg atggctccac cgaggaggag     2040

cgcattgtgg gacgcttcaa gggctccctc tgcgtgtaca aagtgccact cccagaggac     2100

gtgtcccggg aagccggcta cgactccacc tacggcatgt tccagggcat cccgagcaat     2160

gaccccatca atgtgctggt ccgagtctat gtggtccggg ccacggacct gcaccctgct     2220

gacatcaacg gcaaagctga cccctacatc gccatccggc taggcaagac tgacatccgc     2280

gacaaggaga actacatctc caagcagctc aaccctgtct ttgggaagtc ctttgacatc     2340

gaggcctcct tccccatgga atccatgctg acggtggctg tgtatgactg ggacctggtg     2400

ggcactgatg acctcattgg ggaaaccaag atcgacctgg agaaccgctt ctacagcaag     2460

caccgcgcca cctgcggcat cgcccagacc tactccacac atggctacaa tatctggcgg     2520

gaccccatga agcccagcca gatcctgacc cgcctctgca aagacggcaa agtggacggc     2580

ccccactttg ggccccctgg gagagtgaag gtggccaacc gcgtcttcac tgggccctct     2640

gagattgagg acgagaacgg tcagaggaag cccacagacg agcatgtggc gctgttggcc     2700

ctgaggcact gggaggacat cccccgcgca ggctgccgcc tggtgccaga gcatgtggag     2760

acgaggccgc tgctcaaccc cgacaagccg ggcatcgagc agggccgcct ggagctgtgg     2820

gtggacatgt tccccatgga catgccagcc cctgggacgc ctctggacat ctcacctcgg     2880

aagcccaaga agtacgagct gcgggtcatc atctggaaca cagatgaggt ggtcttggag     2940

gacgacgact tcttcacagg ggagaagtcc agtgacatct tcgtgagggg gtggctgaag     3000

ggccagcagg aggacaagca ggacacagac gtccactacc actccctcac tggcgagggc     3060

aacttcaact ggcgctacct gttccccttc gactacctgg cggcggagga gaagatcgtc     3120

atctccaaga aggagtccat gttctcctgg gacgagaccg agtacaagat ccccgcgcgg     3180

ctcaccctgc agatctggga tgcggaccac ttctccgctg acgacttcct gggggccatc     3240

gagctggacc tgaaccggtt cccgcggggc gcaaagacag ccaagcagtg caccatggag     3300

atggccaccg gggaggtgga cgtgcccctc gtgtccatct tcaagcaaaa gcgcgtcaaa     3360

ggctggtggc ccctcctggc ccgcaatgag aacgatgagt ttgagctcac gggcaaggtg     3420

gaggctgagc tgcatttact gacagcagag gaggcagaga agaacccagt gggcctggcc     3480

cgcaatgaac ctgaccccct agagaaaccc aaccggcccg acacgagctt catctggttc     3540

ctgaaccctc tcaagtcggc tcgctacttc ttgtggcaca cgtatcgctg gctgctcctc     3600

aaactgttgc tgctcctgct gctgctcctc ctcctcgccc tgttcctcta ctctgtgcct     3660

ggctacctgg tcaagaaaat cctcggggcc tga                                  3693


<210>  7
<211>  1307
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Met Thr Asp Thr Gln Asp Gly Pro Ser Glu Ser Ser Gln Ile Met 
1               5                   10                  15      


Arg Ser Leu Thr Pro Leu Ile Asn Arg Glu Glu Ala Phe Gly Glu Ala 
            20                  25                  30          


Gly Glu Ala Gly Leu Trp Pro Ser Ile Thr His Thr Pro Asp Ser Gln 
        35                  40                  45              


Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu Lys Ser 
    50                  55                  60                  


Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys Gly 
65                  70                  75                  80  


Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His Ser Ser 
                85                  90                  95      


Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu Leu 
            100                 105                 110         


Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val Lys Arg 
        115                 120                 125             


His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu Gln Lys 
    130                 135                 140                 


Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Ile Phe 
145                 150                 155                 160 


Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg Val Pro 
                165                 170                 175     


Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly Lys Asp 
            180                 185                 190         


Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg Gly 
        195                 200                 205             


Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu Tyr Leu 
    210                 215                 220                 


Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly Leu Pro 
225                 230                 235                 240 


Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His Ala 
                245                 250                 255     


Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln Leu 
            260                 265                 270         


Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser Ser 
        275                 280                 285             


Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln Ser Gln 
    290                 295                 300                 


Cys Thr Glu Val Leu Asn Glu Thr Leu Cys Pro Thr Trp Asp Gln Met 
305                 310                 315                 320 


Leu Val Phe Asp Asn Leu Glu Leu Tyr Gly Glu Ala His Glu Leu Arg 
                325                 330                 335     


Asp Asp Pro Pro Ile Ile Val Ile Glu Ile Tyr Asp Gln Asp Ser Met 
            340                 345                 350         


Gly Lys Ala Asp Phe Met Gly Arg Thr Phe Ala Lys Pro Leu Val Lys 
        355                 360                 365             


Met Ala Asp Glu Ala Tyr Cys Pro Pro Arg Phe Pro Pro Gln Leu Glu 
    370                 375                 380                 


Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala Thr Ala Gly Asp Leu Leu Ala 
385                 390                 395                 400 


Ala Phe Glu Leu Leu Gln Ile Gly Pro Ala Gly Lys Ala Asp Leu Pro 
                405                 410                 415     


Pro Ile Asn Gly Pro Val Asp Val Asp Arg Gly Pro Ile Met Pro Val 
            420                 425                 430         


Pro Met Gly Ile Arg Pro Val Leu Ser Lys Tyr Arg Val Glu Val Leu 
        435                 440                 445             


Phe Trp Gly Leu Arg Asp Leu Lys Arg Val Asn Leu Ala Gln Val Asp 
    450                 455                 460                 


Arg Pro Arg Val Asp Ile Glu Cys Ala Gly Lys Gly Val Gln Ser Ser 
465                 470                 475                 480 


Leu Ile His Asn Tyr Lys Lys Asn Pro Asn Phe Asn Thr Leu Val Lys 
                485                 490                 495     


Trp Phe Glu Val Asp Leu Pro Glu Asn Glu Leu Leu His Pro Pro Leu 
            500                 505                 510         


Asn Ile Arg Val Val Asp Cys Arg Ala Phe Gly Arg Tyr Thr Leu Val 
        515                 520                 525             


Gly Ser His Ala Val Ser Ser Leu Arg Arg Phe Ile Tyr Arg Pro Pro 
    530                 535                 540                 


Asp Arg Ser Ala Pro Ser Trp Asn Thr Thr Val Arg Leu Leu Arg Arg 
545                 550                 555                 560 


Cys Arg Val Leu Cys Asn Gly Gly Ser Ser Ser His Ser Thr Gly Glu 
                565                 570                 575     


Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys Leu Glu Thr 
            580                 585                 590         


Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys Val Asp Val 
        595                 600                 605             


Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly Thr Ala Glu 
    610                 615                 620                 


Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp Trp Trp Ser 
625                 630                 635                 640 


Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu Arg Gln Gln 
                645                 650                 655     


Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val Asp Asn Thr 
            660                 665                 670         


Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala Arg Ala Ala 
        675                 680                 685             


Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser Gly Gln Gly 
    690                 695                 700                 


Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu Leu Lys Val 
705                 710                 715                 720 


Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu Asp Trp Leu 
                725                 730                 735     


His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp Glu Asp Gly 
            740                 745                 750         


Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly Ser Leu Cys 
        755                 760                 765             


Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu Ala Gly Tyr 
    770                 775                 780                 


Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn Asp Pro Ile 
785                 790                 795                 800 


Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp Leu His Pro 
                805                 810                 815     


Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile Arg Leu Gly 
            820                 825                 830         


Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys Gln Leu Asn 
        835                 840                 845             


Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe Pro Met Glu 
    850                 855                 860                 


Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val Gly Thr Asp 
865                 870                 875                 880 


Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg Phe Tyr Ser 
                885                 890                 895     


Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser Thr His Gly 
            900                 905                 910         


Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile Leu Thr Arg 
        915                 920                 925             


Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly Pro Pro Gly 
    930                 935                 940                 


Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser Glu Ile Glu 
945                 950                 955                 960 


Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val Ala Leu Leu 
                965                 970                 975     


Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys Arg Leu Val 
            980                 985                 990         


Pro Glu His Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
        995                 1000                 1005             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1010                 1015                 1020             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1025                 1030                 1035             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1040                 1045                 1050             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1055                 1060                 1065             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1070                 1075                 1080             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1085                 1090                 1095             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1100                 1105                 1110             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1115                 1120                 1125             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1130                 1135                 1140             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1145                 1150                 1155             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1160                 1165                 1170             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1175                 1180                 1185             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1190                 1195                 1200             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1205                 1210                 1215             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1220                 1225                 1230             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1235                 1240                 1245             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1250                 1255                 1260             


Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys 
    1265                 1270                 1275             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Leu Leu Ala  Leu Phe Leu 
    1280                 1285                 1290             


Tyr Ser  Val Pro Gly Tyr Leu  Val Lys Lys Ile Leu  Gly Ala 
    1295                 1300                 1305         


<210>  8
<211>  3924
<212>  DNA
<213>  Homo sapiens

<400>  8
atgatgaccg atactcagga tggccctagc gagagctccc agatcatgag gtccctcact       60

cccctgatca acagggagga ggcatttggg gaggctgggg aggcggggct gtggcccagc      120

atcacccaca ctcctgattc acaggaagaa ggcctgaacg acatacagga gatgatcaaa      180

acggagaagt cctaccctga gcgtcgcctg cggggcgtcc tggaggagct gagctgtggc      240

tgctgccgct tcctctccct cgctgacaag gaccagggcc actcatcccg caccaggctt      300

gaccgggagc gcctcaagtc ctgcatgagg gagctggaaa acatggggca gcaggccagg      360

atgctgcggg cccaggtgaa gcggcacacg gtgcgggaca agctgaggct gtgccagaac      420

ttcctgcaga agctgcgctt cctggcggac gagccccagc acagcattcc cgacatcttc      480

atctggatga tgagcaacaa caagcgtgtc gcctatgccc gtgtgccctc caaggacctg      540

ctcttctcca tcgtggagga ggagactggc aaggactgcg ccaaggtcaa gacgctcttc      600

cttaagctgc cagggaagcg gggcttcggc tcggcaggct ggacagtgca ggccaaggtg      660

gagctgtacc tgtggctggg cctcagcaaa cagcgcaagg agttcctgtg cggcctgccc      720

tgtggcttcc aggaggtcaa ggcagcccag ggcctgggcc tgcatgcctt cccacccgtc      780

agcctggtct acaccaagaa gcaggcgttc cagctccgag cgcacatgta ccaggcccgc      840

agcctctttg ccgccgacag cagcggactc tcagacccct ttgcccgcgt cttcttcatc      900

aatcagagtc agtgcacaga ggtgctgaat gagaccctgt gtcccacctg ggaccagatg      960

ctggtgttcg acaacctgga gctctatggt gaagctcatg agctgaggga cgatccgccc     1020

atcattgtca ttgaaatcta tgaccaggat tccatgggca aagctgactt catgggccgg     1080

accttcgcca aacccctggt gaagatggca gacgaggcgt actgcccacc ccgcttccca     1140

cctcagctcg agtactacca gatctaccgt ggcaacgcca cagctggaga cctgctggcg     1200

gccttcgagc tgctgcagat tggaccagca gggaaggctg acctgccccc catcaatggc     1260

ccggtggacg tggaccgagg tcccatcatg cccgtgccca tgggcatccg gcccgtgctc     1320

agcaagtacc gagtggaggt gctgttctgg ggcctacggg acctaaagcg ggtgaacctg     1380

gcccaggtgg accggccacg ggtggacatc gagtgtgcag ggaagggggt gcagtcgtcc     1440

ctgatccaca attataagaa gaaccccaac ttcaacaccc tcgtcaagtg gtttgaagtg     1500

gacctcccag agaacgagct gctgcacccg cccttgaaca tccgtgtggt ggactgccgg     1560

gccttcggtc gctacacact ggtgggctcc catgccgtca gctccctgcg acgcttcatc     1620

taccggcccc cagaccgctc ggcccccagc tggaacacca cggtcaggct tctccggcgc     1680

tgccgtgtgc tgtgcaatgg gggctcctcc tctcactcca caggggaggt tgtggtgact     1740

atggagccag aggtacccat caagaaactg gagaccatgg tgaagctgga cgcgacttct     1800

gaagctgttg tcaaggtgga tgtggctgag gaggagaagg agaagaagaa gaagaagaag     1860

ggcactgcgg aggagccaga ggaggaggag ccagacgaga gcatgctgga ctggtggtcc     1920

aagtactttg cctccattga caccatgaag gagcaacttc gacaacaaga gccctctgga     1980

attgacttgg aggagaagga ggaagtggac aataccgagg gcctgaaggg gtcaatgaag     2040

ggcaaggaga aggcaagggc tgccaaagag gagaagaaga agaaaactca gagctctggc     2100

tctggccagg ggtccgaggc ccccgagaag aagaaaccca agattgatga gcttaaggta     2160

taccccaaag agctggagtc cgagtttgat aactttgagg actggctgca cactttcaac     2220

ttgcttcggg gcaagaccgg ggatgatgag gatggctcca ccgaggagga gcgcattgtg     2280

ggacgcttca agggctccct ctgcgtgtac aaagtgccac tcccagagga cgtgtcccgg     2340

gaagccggct acgactccac ctacggcatg ttccagggca tcccgagcaa tgaccccatc     2400

aatgtgctgg tccgagtcta tgtggtccgg gccacggacc tgcaccctgc tgacatcaac     2460

ggcaaagctg acccctacat cgccatccgg ctaggcaaga ctgacatccg cgacaaggag     2520

aactacatct ccaagcagct caaccctgtc tttgggaagt cctttgacat cgaggcctcc     2580

ttccccatgg aatccatgct gacggtggct gtgtatgact gggacctggt gggcactgat     2640

gacctcattg gggaaaccaa gatcgacctg gagaaccgct tctacagcaa gcaccgcgcc     2700

acctgcggca tcgcccagac ctactccaca catggctaca atatctggcg ggaccccatg     2760

aagcccagcc agatcctgac ccgcctctgc aaagacggca aagtggacgg cccccacttt     2820

gggccccctg ggagagtgaa ggtggccaac cgcgtcttca ctgggccctc tgagattgag     2880

gacgagaacg gtcagaggaa gcccacagac gagcatgtgg cgctgttggc cctgaggcac     2940

tgggaggaca tcccccgcgc aggctgccgc ctggtgccag agcatgtgga gacgaggccg     3000

ctgctcaacc ccgacaagcc gggcatcgag cagggccgcc tggagctgtg ggtggacatg     3060

ttccccatgg acatgccagc ccctgggacg cctctggaca tctcacctcg gaagcccaag     3120

aagtacgagc tgcgggtcat catctggaac acagatgagg tggtcttgga ggacgacgac     3180

ttcttcacag gggagaagtc cagtgacatc ttcgtgaggg ggtggctgaa gggccagcag     3240

gaggacaagc aggacacaga cgtccactac cactccctca ctggcgaggg caacttcaac     3300

tggcgctacc tgttcccctt cgactacctg gcggcggagg agaagatcgt catctccaag     3360

aaggagtcca tgttctcctg ggacgagacc gagtacaaga tccccgcgcg gctcaccctg     3420

cagatctggg atgcggacca cttctccgct gacgacttcc tgggggccat cgagctggac     3480

ctgaaccggt tcccgcgggg cgcaaagaca gccaagcagt gcaccatgga gatggccacc     3540

ggggaggtgg acgtgcccct cgtgtccatc ttcaagcaaa agcgcgtcaa aggctggtgg     3600

cccctcctgg cccgcaatga gaacgatgag tttgagctca cgggcaaggt ggaggctgag     3660

ctgcatttac tgacagcaga ggaggcagag aagaacccag tgggcctggc ccgcaatgaa     3720

cctgaccccc tagagaaacc caaccggccc gacacgagct tcatctggtt cctgaaccct     3780

ctcaagtcgg ctcgctactt cttgtggcac acgtatcgct ggctgctcct caaactgttg     3840

ctgctcctgc tgctgctcct cctcctcgcc ctgttcctct actctgtgcc tggctacctg     3900

gtcaagaaaa tcctcggggc ctga                                            3924


<210>  9
<211>  1230
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ile Lys Thr Glu Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val 
1               5                   10                  15      


Leu Glu Glu Leu Ser Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp 
            20                  25                  30          


Lys Asp Gln Gly His Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu 
        35                  40                  45              


Lys Ser Cys Met Arg Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met 
    50                  55                  60                  


Leu Arg Ala Gln Val Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu 
65                  70                  75                  80  


Cys Gln Asn Phe Leu Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln 
                85                  90                  95      


His Ser Ile Pro Asp Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg 
            100                 105                 110         


Val Ala Tyr Ala Arg Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val 
        115                 120                 125             


Glu Glu Glu Thr Gly Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu 
    130                 135                 140                 


Lys Leu Pro Gly Lys Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln 
145                 150                 155                 160 


Ala Lys Val Glu Leu Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys 
                165                 170                 175     


Glu Phe Leu Cys Gly Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala 
            180                 185                 190         


Gln Gly Leu Gly Leu His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr 
        195                 200                 205             


Lys Lys Gln Ala Phe Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser 
    210                 215                 220                 


Leu Phe Ala Ala Asp Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val 
225                 230                 235                 240 


Phe Phe Ile Asn Gln Ser Gln Cys Thr Glu Val Leu Asn Glu Thr Leu 
                245                 250                 255     


Cys Pro Thr Trp Asp Gln Met Leu Val Phe Asp Asn Leu Glu Leu Tyr 
            260                 265                 270         


Gly Glu Ala His Glu Leu Arg Asp Asp Pro Pro Ile Ile Val Ile Glu 
        275                 280                 285             


Ile Tyr Asp Gln Asp Ser Met Gly Lys Ala Asp Phe Met Gly Arg Thr 
    290                 295                 300                 


Phe Ala Lys Pro Leu Val Lys Met Ala Asp Glu Ala Tyr Cys Pro Pro 
305                 310                 315                 320 


Arg Phe Pro Pro Gln Leu Glu Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala 
                325                 330                 335     


Thr Ala Gly Asp Leu Leu Ala Ala Phe Glu Leu Leu Gln Ile Gly Pro 
            340                 345                 350         


Ala Gly Lys Ala Asp Leu Pro Pro Ile Asn Gly Pro Val Asp Val Asp 
        355                 360                 365             


Arg Gly Pro Ile Met Pro Val Pro Met Gly Ile Arg Pro Val Leu Ser 
    370                 375                 380                 


Lys Tyr Arg Val Glu Val Leu Phe Trp Gly Leu Arg Asp Leu Lys Arg 
385                 390                 395                 400 


Val Asn Leu Ala Gln Val Asp Arg Pro Arg Val Asp Ile Glu Cys Ala 
                405                 410                 415     


Gly Lys Gly Val Gln Ser Ser Leu Ile His Asn Tyr Lys Lys Asn Pro 
            420                 425                 430         


Asn Phe Asn Thr Leu Val Lys Trp Phe Glu Val Asp Leu Pro Glu Asn 
        435                 440                 445             


Glu Leu Leu His Pro Pro Leu Asn Ile Arg Val Val Asp Cys Arg Ala 
    450                 455                 460                 


Phe Gly Arg Tyr Thr Leu Val Gly Ser His Ala Val Ser Ser Leu Arg 
465                 470                 475                 480 


Arg Phe Ile Tyr Arg Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr 
                485                 490                 495     


Thr Gly Glu Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys 
            500                 505                 510         


Leu Glu Thr Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys 
        515                 520                 525             


Val Asp Val Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly 
    530                 535                 540                 


Thr Ala Glu Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp 
545                 550                 555                 560 


Trp Trp Ser Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu 
                565                 570                 575     


Arg Gln Gln Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val 
            580                 585                 590         


Asp Asn Thr Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala 
        595                 600                 605             


Arg Ala Ala Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser 
    610                 615                 620                 


Gly Gln Gly Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu 
625                 630                 635                 640 


Leu Lys Val Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu 
                645                 650                 655     


Asp Trp Leu His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp 
            660                 665                 670         


Glu Asp Gly Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly 
        675                 680                 685             


Ser Leu Cys Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu 
    690                 695                 700                 


Ala Gly Tyr Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn 
705                 710                 715                 720 


Asp Pro Ile Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp 
                725                 730                 735     


Leu His Pro Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile 
            740                 745                 750         


Arg Leu Gly Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys 
        755                 760                 765             


Gln Leu Asn Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe 
    770                 775                 780                 


Pro Met Glu Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val 
785                 790                 795                 800 


Gly Thr Asp Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg 
                805                 810                 815     


Phe Tyr Ser Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser 
            820                 825                 830         


Thr His Gly Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile 
        835                 840                 845             


Leu Thr Arg Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly 
    850                 855                 860                 


Pro Pro Gly Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser 
865                 870                 875                 880 


Glu Ile Glu Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val 
                885                 890                 895     


Ala Leu Leu Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys 
            900                 905                 910         


Arg Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Leu Asn Pro Asp 
        915                 920                 925             


Lys Pro Gly Ile Glu Gln Gly Arg Leu Glu Leu Trp Val Asp Met Phe 
    930                 935                 940                 


Pro Met Asp Met Pro Ala Pro Gly Thr Pro Leu Asp Ile Ser Pro Arg 
945                 950                 955                 960 


Lys Pro Lys Lys Tyr Glu Leu Arg Val Ile Ile Trp Asn Thr Asp Glu 
                965                 970                 975     


Val Val Leu Glu Asp Asp Asp Phe Phe Thr Gly Glu Lys Ser Ser Asp 
            980                 985                 990         


Ile Phe Val Arg Gly Trp Leu Lys  Gly Gln Gln Glu Asp  Lys Gln Asp 
        995                 1000                 1005             


Thr Asp  Val His Tyr His Ser  Leu Thr Gly Glu Gly  Asn Phe Asn 
    1010                 1015                 1020             


Trp Arg  Tyr Leu Phe Pro Phe  Asp Tyr Leu Ala Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ile Val  Ile Ser Lys Lys Glu  Ser Met Phe Ser Trp  Asp Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Lys Ile Pro Ala Arg  Leu Thr Leu Gln Ile  Trp Asp Ala 
    1055                 1060                 1065             


Asp His  Phe Ser Ala Asp Asp  Phe Leu Gly Ala Ile  Glu Leu Asp 
    1070                 1075                 1080             


Leu Asn  Arg Phe Pro Arg Gly  Ala Lys Thr Ala Lys  Gln Cys Thr 
    1085                 1090                 1095             


Met Glu  Met Ala Thr Gly Glu  Val Asp Val Pro Leu  Val Ser Ile 
    1100                 1105                 1110             


Phe Lys  Gln Lys Arg Val Lys  Gly Trp Trp Pro Leu  Leu Ala Arg 
    1115                 1120                 1125             


Asn Glu  Asn Asp Glu Phe Glu  Leu Thr Gly Lys Val  Glu Ala Glu 
    1130                 1135                 1140             


Leu His  Leu Leu Thr Ala Glu  Glu Ala Glu Lys Asn  Pro Val Gly 
    1145                 1150                 1155             


Leu Ala  Arg Asn Glu Pro Asp  Pro Leu Glu Lys Pro  Asn Arg Pro 
    1160                 1165                 1170             


Asp Thr  Ala Phe Val Trp Phe  Leu Asn Pro Leu Lys  Ser Ile Lys 
    1175                 1180                 1185             


Tyr Leu  Ile Cys Thr Arg Tyr  Lys Trp Leu Ile Ile  Lys Ile Val 
    1190                 1195                 1200             


Leu Ala  Leu Leu Gly Leu Leu  Met Leu Gly Leu Phe  Leu Tyr Ser 
    1205                 1210                 1215             


Leu Pro  Gly Tyr Met Val Lys  Lys Leu Leu Gly Ala  
    1220                 1225                 1230 


<210>  10
<211>  3693
<212>  DNA
<213>  Homo sapiens

<400>  10
atgatcaaaa cggagaagtc ctaccctgag cgtcgcctgc ggggcgtcct ggaggagctg       60

agctgtggct gctgccgctt cctctccctc gctgacaagg accagggcca ctcatcccgc      120

accaggcttg accgggagcg cctcaagtcc tgcatgaggg agctggaaaa catggggcag      180

caggccagga tgctgcgggc ccaggtgaag cggcacacgg tgcgggacaa gctgaggctg      240

tgccagaact tcctgcagaa gctgcgcttc ctggcggacg agccccagca cagcattccc      300

gacatcttca tctggatgat gagcaacaac aagcgtgtcg cctatgcccg tgtgccctcc      360

aaggacctgc tcttctccat cgtggaggag gagactggca aggactgcgc caaggtcaag      420

acgctcttcc ttaagctgcc agggaagcgg ggcttcggct cggcaggctg gacagtgcag      480

gccaaggtgg agctgtacct gtggctgggc ctcagcaaac agcgcaagga gttcctgtgc      540

ggcctgccct gtggcttcca ggaggtcaag gcagcccagg gcctgggcct gcatgccttc      600

ccacccgtca gcctggtcta caccaagaag caggcgttcc agctccgagc gcacatgtac      660

caggcccgca gcctctttgc cgccgacagc agcggactct cagacccctt tgcccgcgtc      720

ttcttcatca atcagagtca gtgcacagag gtgctgaatg agaccctgtg tcccacctgg      780

gaccagatgc tggtgttcga caacctggag ctctatggtg aagctcatga gctgagggac      840

gatccgccca tcattgtcat tgaaatctat gaccaggatt ccatgggcaa agctgacttc      900

atgggccgga ccttcgccaa acccctggtg aagatggcag acgaggcgta ctgcccaccc      960

cgcttcccac ctcagctcga gtactaccag atctaccgtg gcaacgccac agctggagac     1020

ctgctggcgg ccttcgagct gctgcagatt ggaccagcag ggaaggctga cctgcccccc     1080

atcaatggcc cggtggacgt ggaccgaggt cccatcatgc ccgtgcccat gggcatccgg     1140

cccgtgctca gcaagtaccg agtggaggtg ctgttctggg gcctacggga cctaaagcgg     1200

gtgaacctgg cccaggtgga ccggccacgg gtggacatcg agtgtgcagg gaagggggtg     1260

cagtcgtccc tgatccacaa ttataagaag aaccccaact tcaacaccct cgtcaagtgg     1320

tttgaagtgg acctcccaga gaacgagctg ctgcacccgc ccttgaacat ccgtgtggtg     1380

gactgccggg ccttcggtcg ctacacactg gtgggctccc atgccgtcag ctccctgcga     1440

cgcttcatct accggccccc agaccgctcg gcccccagct ggaacaccac gggggaggtt     1500

gtggtgacta tggagccaga ggtacccatc aagaaactgg agaccatggt gaagctggac     1560

gcgacttctg aagctgttgt caaggtggat gtggctgagg aggagaagga gaagaagaag     1620

aagaagaagg gcactgcgga ggagccagag gaggaggagc cagacgagag catgctggac     1680

tggtggtcca agtactttgc ctccattgac accatgaagg agcaacttcg acaacaagag     1740

ccctctggaa ttgacttgga ggagaaggag gaagtggaca ataccgaggg cctgaagggg     1800

tcaatgaagg gcaaggagaa ggcaagggct gccaaagagg agaagaagaa gaaaactcag     1860

agctctggct ctggccaggg gtccgaggcc cccgagaaga agaaacccaa gattgatgag     1920

cttaaggtat accccaaaga gctggagtcc gagtttgata actttgagga ctggctgcac     1980

actttcaact tgcttcgggg caagaccggg gatgatgagg atggctccac cgaggaggag     2040

cgcattgtgg gacgcttcaa gggctccctc tgcgtgtaca aagtgccact cccagaggac     2100

gtgtcccggg aagccggcta cgactccacc tacggcatgt tccagggcat cccgagcaat     2160

gaccccatca atgtgctggt ccgagtctat gtggtccggg ccacggacct gcaccctgct     2220

gacatcaacg gcaaagctga cccctacatc gccatccggc taggcaagac tgacatccgc     2280

gacaaggaga actacatctc caagcagctc aaccctgtct ttgggaagtc ctttgacatc     2340

gaggcctcct tccccatgga atccatgctg acggtggctg tgtatgactg ggacctggtg     2400

ggcactgatg acctcattgg ggaaaccaag atcgacctgg agaaccgctt ctacagcaag     2460

caccgcgcca cctgcggcat cgcccagacc tactccacac atggctacaa tatctggcgg     2520

gaccccatga agcccagcca gatcctgacc cgcctctgca aagacggcaa agtggacggc     2580

ccccactttg ggccccctgg gagagtgaag gtggccaacc gcgtcttcac tgggccctct     2640

gagattgagg acgagaacgg tcagaggaag cccacagacg agcatgtggc gctgttggcc     2700

ctgaggcact gggaggacat cccccgcgca ggctgccgcc tggtgccaga gcatgtggag     2760

acgaggccgc tgctcaaccc cgacaagccg ggcatcgagc agggccgcct ggagctgtgg     2820

gtggacatgt tccccatgga catgccagcc cctgggacgc ctctggacat ctcacctcgg     2880

aagcccaaga agtacgagct gcgggtcatc atctggaaca cagatgaggt ggtcttggag     2940

gacgacgact tcttcacagg ggagaagtcc agtgacatct tcgtgagggg gtggctgaag     3000

ggccagcagg aggacaagca ggacacagac gtccactacc actccctcac tggcgagggc     3060

aacttcaact ggcgctacct gttccccttc gactacctgg cggcggagga gaagatcgtc     3120

atctccaaga aggagtccat gttctcctgg gacgagaccg agtacaagat ccccgcgcgg     3180

ctcaccctgc agatctggga tgcggaccac ttctccgctg acgacttcct gggggccatc     3240

gagctggacc tgaaccggtt cccgcggggc gcaaagacag ccaagcagtg caccatggag     3300

atggccaccg gggaggtgga cgtgcccctc gtgtccatct tcaagcaaaa gcgcgtcaaa     3360

ggctggtggc ccctcctggc ccgcaatgag aacgatgagt ttgagctcac gggcaaggtg     3420

gaggctgagc tgcatttact gacagcagag gaggcagaga agaacccagt gggcctggcc     3480

cgcaatgaac ctgaccccct agagaaaccc aaccggcccg acacggcctt cgtctggttc     3540

ctcaaccctc tcaagtccat caagtacctc atctgcaccc ggtacaagtg gctcatcatc     3600

aagatcgtgc tggcgctgtt ggggctgctc atgttggggc tcttcctcta cagcctccct     3660

ggctacatgg tcaaaaagct ccttggggca tga                                  3693


<210>  11
<211>  1992
<212>  PRT
<213>  Mus musculus

<400>  11

Met Ala Leu Ile Val His Leu Lys Thr Val Ser Glu Leu Arg Gly Lys 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Gly Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Val Leu Glu Ile 
    50                  55                  60                  


Gln Ile Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Cys Met Val Leu Gln Lys Val Val Glu Glu Asn Arg Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Met Asp Asp Ser Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Ser Met Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Pro Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Lys Asp 
    130                 135                 140                 


Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Ser Gly Glu Lys Ser Phe Arg Ser Lys Gly Arg Glu Glu Thr Lys 
                165                 170                 175     


Gly Gly Arg Asp Gly Glu His Lys Ala Gly Arg Ser Val Phe Ser Ala 
            180                 185                 190         


Met Lys Leu Gly Lys Thr Arg Ser His Lys Glu Glu Pro Gln Arg Gln 
        195                 200                 205             


Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu Ala Ile 
    210                 215                 220                 


Gln Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala Ser Val 
225                 230                 235                 240 


Thr Ala Leu Thr Ser Asn Val Ser Asn Lys Arg Ser Lys Pro Asp Ile 
                245                 250                 255     


Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val Ser Ile 
            260                 265                 270         


Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp Pro Val 
        275                 280                 285             


Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met Lys Glu 
    290                 295                 300                 


Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp Phe His 
305                 310                 315                 320 


Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser Val Ile 
                325                 330                 335     


His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser Phe Lys 
            340                 345                 350         


Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe His His 
        355                 360                 365             


Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ala Gly Leu Lys 
    370                 375                 380                 


Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp Asn Ile 
385                 390                 395                 400 


Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile Glu Gly 
                405                 410                 415     


Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp Ala Arg 
            420                 425                 430         


Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met Asn Thr 
        435                 440                 445             


Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn Lys Asp 
    450                 455                 460                 


Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys Gly Lys 
465                 470                 475                 480 


Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu Gln Val 
                485                 490                 495     


Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys Val Gln 
            500                 505                 510         


Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His Phe 
        515                 520                 525             


Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe Leu Pro 
    530                 535                 540                 


Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg Asn Tyr 
545                 550                 555                 560 


Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly Glu Gly 
                565                 570                 575     


Val Ser Phe Arg Ala Arg Leu Met Leu Gly Leu Ala Val Glu Ile Leu 
            580                 585                 590         


Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln Val Glu 
        595                 600                 605             


Gln Ala Thr Pro Val Ser Glu Ser Cys Thr Gly Arg Met Glu Glu Phe 
    610                 615                 620                 


Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg Lys Asn 
625                 630                 635                 640 


Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr Gly Asn 
                645                 650                 655     


Glu Val Asp Gly Met Ser Arg Pro Leu Arg Pro Arg Pro Arg Lys Glu 
            660                 665                 670         


Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ser Ser Asp Asp 
        675                 680                 685             


Glu Gly Asp Glu Ala Gly Asp Leu Ala Ser Val Ser Ser Thr Pro Pro 
    690                 695                 700                 


Met Arg Pro Gln Ile Thr Asp Arg Asn Tyr Phe His Leu Pro Tyr Leu 
705                 710                 715                 720 


Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp Gln Arg 
                725                 730                 735     


Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp Lys Leu 
            740                 745                 750         


Glu Glu Gly Leu Asn Asp Val Gln Glu Met Ile Lys Thr Glu Lys Ser 
        755                 760                 765             


Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys Gly 
    770                 775                 780                 


Cys His Arg Phe Leu Ser Leu Ser Asp Lys Asp Gln Gly Arg Ser Ser 
785                 790                 795                 800 


Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu Leu 
                805                 810                 815     


Glu Ser Met Gly Gln Gln Ala Lys Ser Leu Arg Ala Gln Val Lys Arg 
            820                 825                 830         


His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu Gln Lys 
        835                 840                 845             


Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Val Phe 
    850                 855                 860                 


Ile Trp Met Met Ser Asn Asn Lys Arg Ile Ala Tyr Ala Arg Val Pro 
865                 870                 875                 880 


Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Leu Gly Lys Asp 
                885                 890                 895     


Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg Gly 
            900                 905                 910         


Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Leu Glu Leu Tyr Leu 
        915                 920                 925             


Trp Leu Gly Leu Ser Lys Gln Arg Lys Asp Phe Leu Cys Gly Leu Pro 
    930                 935                 940                 


Cys Gly Phe Glu Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His Ser 
945                 950                 955                 960 


Phe Pro Pro Ile Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln Leu 
                965                 970                 975     


Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser Ser 
            980                 985                 990         


Gly Leu Ser Asp Pro Phe Ala Arg  Val Phe Phe Ile Asn  Gln Ser Gln 
        995                 1000                 1005             


Cys Thr  Glu Val Leu Asn Glu  Thr Leu Cys Pro Thr  Trp Asp Gln 
    1010                 1015                 1020             


Met Leu  Val Phe Asp Asn Leu  Glu Leu Tyr Gly Glu  Ala His Glu 
    1025                 1030                 1035             


Leu Arg  Asp Asp Pro Pro Ile  Ile Val Ile Glu Ile  Tyr Asp Gln 
    1040                 1045                 1050             


Asp Ser  Met Gly Lys Ala Asp  Phe Met Gly Arg Thr  Phe Ala Lys 
    1055                 1060                 1065             


Pro Leu  Val Lys Met Ala Asp  Glu Ala Tyr Cys Pro  Pro Arg Phe 
    1070                 1075                 1080             


Pro Pro  Gln Leu Glu Tyr Tyr  Gln Ile Tyr Arg Gly  Ser Ala Thr 
    1085                 1090                 1095             


Ala Gly  Asp Leu Leu Ala Ala  Phe Glu Leu Leu Gln  Ile Gly Pro 
    1100                 1105                 1110             


Ser Gly  Lys Ala Asp Leu Pro  Pro Ile Asn Gly Pro  Val Asp Met 
    1115                 1120                 1125             


Asp Arg  Gly Pro Ile Met Pro  Val Pro Val Gly Ile  Arg Pro Val 
    1130                 1135                 1140             


Leu Ser  Lys Tyr Arg Val Glu  Val Leu Phe Trp Gly  Leu Arg Asp 
    1145                 1150                 1155             


Leu Lys  Arg Val Asn Leu Ala  Gln Val Asp Arg Pro  Arg Val Asp 
    1160                 1165                 1170             


Ile Glu  Cys Ala Gly Lys Gly  Val Gln Ser Ser Leu  Ile His Asn 
    1175                 1180                 1185             


Tyr Lys  Lys Asn Pro Asn Phe  Asn Thr Leu Val Lys  Trp Phe Glu 
    1190                 1195                 1200             


Val Asp  Leu Pro Glu Asn Glu  Leu Leu His Pro Pro  Leu Asn Ile 
    1205                 1210                 1215             


Arg Val  Val Asp Cys Arg Ala  Phe Gly Arg Tyr Thr  Leu Val Gly 
    1220                 1225                 1230             


Ser His  Ala Val Ser Ser Leu  Arg Arg Phe Ile Tyr  Arg Pro Pro 
    1235                 1240                 1245             


Asp Arg  Ser Ala Pro Asn Trp  Asn Thr Thr Gly Glu  Val Val Val 
    1250                 1255                 1260             


Ser Met  Glu Pro Glu Glu Pro  Val Lys Lys Leu Glu  Thr Met Val 
    1265                 1270                 1275             


Lys Leu  Asp Ala Thr Ser Asp  Ala Val Val Lys Val  Asp Val Ala 
    1280                 1285                 1290             


Glu Asp  Glu Lys Glu Arg Lys  Lys Lys Lys Lys Lys  Gly Pro Ser 
    1295                 1300                 1305             


Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu Ser Met  Leu Asp Trp 
    1310                 1315                 1320             


Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr Met Lys  Glu Gln Leu 
    1325                 1330                 1335             


Arg Gln  His Glu Thr Ser Gly  Thr Asp Leu Glu Glu  Lys Glu Glu 
    1340                 1345                 1350             


Met Glu  Ser Ala Glu Gly Leu  Lys Gly Pro Met Lys  Ser Lys Glu 
    1355                 1360                 1365             


Lys Ser  Arg Ala Ala Lys Glu  Glu Lys Lys Lys Lys  Asn Gln Ser 
    1370                 1375                 1380             


Pro Gly  Pro Gly Gln Gly Ser  Glu Ala Pro Glu Lys  Lys Lys Ala 
    1385                 1390                 1395             


Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys Glu Leu  Glu Ser Glu 
    1400                 1405                 1410             


Phe Asp  Ser Phe Glu Asp Trp  Leu His Thr Phe Asn  Leu Leu Arg 
    1415                 1420                 1425             


Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser Thr Glu  Glu Glu Arg 
    1430                 1435                 1440             


Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys Val Tyr  Lys Val Pro 
    1445                 1450                 1455             


Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly Tyr Asp  Pro Thr Tyr 
    1460                 1465                 1470             


Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp Pro Ile  Asn Val Leu 
    1475                 1480                 1485             


Val Arg  Ile Tyr Val Val Arg  Ala Thr Asp Leu His  Pro Ala Asp 
    1490                 1495                 1500             


Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala Ile Lys  Leu Gly Lys 
    1505                 1510                 1515             


Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile Ser Lys  Gln Leu Asn 
    1520                 1525                 1530             


Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu Ala Ser  Phe Pro Met 
    1535                 1540                 1545             


Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp Trp Asp  Leu Val Gly 
    1550                 1555                 1560             


Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile Asp Leu  Glu Asn Arg 
    1565                 1570                 1575             


Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly Ile Ala  Gln Thr Tyr 
    1580                 1585                 1590             


Ser Ile  His Gly Tyr Asn Ile  Trp Arg Asp Pro Met  Lys Pro Ser 
    1595                 1600                 1605             


Gln Ile  Leu Thr Arg Leu Cys  Lys Glu Gly Lys Val  Asp Gly Pro 
    1610                 1615                 1620             


His Phe  Gly Pro His Gly Arg  Val Arg Val Ala Asn  Arg Val Phe 
    1625                 1630                 1635             


Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn Gly Gln  Arg Lys Pro 
    1640                 1645                 1650             


Thr Asp  Glu His Val Ala Leu  Ser Ala Leu Arg His  Trp Glu Asp 
    1655                 1660                 1665             


Ile Pro  Arg Val Gly Cys Arg  Leu Val Pro Glu His  Val Glu Thr 
    1670                 1675                 1680             


Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly Ile Glu  Gln Gly Arg 
    1685                 1690                 1695             


Leu Glu  Leu Trp Val Asp Met  Phe Pro Met Asp Met  Pro Ala Pro 
    1700                 1705                 1710             


Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys Pro Lys  Lys Tyr Glu 
    1715                 1720                 1725             


Leu Arg  Val Ile Val Trp Asn  Thr Asp Glu Val Val  Leu Glu Asp 
    1730                 1735                 1740             


Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser Asp Ile  Phe Val Arg 
    1745                 1750                 1755             


Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys Gln Asp  Thr Asp Val 
    1760                 1765                 1770             


His Tyr  His Ser Leu Thr Gly  Glu Gly Asn Phe Asn  Trp Arg Tyr 
    1775                 1780                 1785             


Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu Glu Lys  Ile Val Met 
    1790                 1795                 1800             


Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp Glu Thr  Glu Tyr Lys 
    1805                 1810                 1815             


Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp Asp Ala  Asp His Phe 
    1820                 1825                 1830             


Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu Leu Asp  Leu Asn Arg 
    1835                 1840                 1845             


Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln Cys Thr  Met Glu Met 
    1850                 1855                 1860             


Ala Thr  Gly Glu Val Asp Val  Pro Leu Val Ser Ile  Phe Lys Gln 
    1865                 1870                 1875             


Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu Ala Arg  Asn Glu Asn 
    1880                 1885                 1890             


Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu Ala Glu  Leu His Leu 
    1895                 1900                 1905             


Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro Val Gly  Leu Ala Arg 
    1910                 1915                 1920             


Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn Arg Pro  Asp Thr Ala 
    1925                 1930                 1935             


Phe Val  Trp Phe Leu Asn Pro  Leu Lys Ser Ile Lys  Tyr Leu Ile 
    1940                 1945                 1950             


Cys Thr  Arg Tyr Lys Trp Leu  Ile Ile Lys Ile Val  Leu Ala Leu 
    1955                 1960                 1965             


Leu Gly  Leu Leu Met Leu Ala  Leu Phe Leu Tyr Ser  Leu Pro Gly 
    1970                 1975                 1980             


Tyr Met  Val Lys Lys Leu Leu  Gly Ala 
    1985                 1990         


<210>  12
<211>  5979
<212>  DNA
<213>  Mus musculus

<400>  12
atggccctga ttgttcacct caagactgtc tcagagctcc gaggcaaagg tgaccggatt       60

gccaaagtca ctttccgagg gcagtctttc tactcccggg tcctggagaa ctgcgagggt      120

gtggctgact ttgatgagac gttccggtgg ccagtggcca gcagcatcga ccggaatgaa      180

gtgttggaga ttcagatttt caactacagc aaagtcttca gcaacaagct gatagggacc      240

ttctgcatgg tgctgcagaa agtggtggag gagaatcggg tagaggtgac cgacacgctg      300

atggatgaca gcaatgctat catcaagacc agcctgagca tggaggtccg gtatcaggcc      360

acagatggca ctgtgggccc ctgggatgat ggagacttcc tgggagatga atccctccag      420

gaggagaagg acagccagga gacagatggg ctgctacctg gttcccgacc cagcacccgg      480

atatctggcg agaagagctt tcgcagcaaa ggcagagaga agaccaaggg aggcagagat      540

ggcgagcaca aagcgggaag gagtgtgttc tcggccatga aactcggcaa aactcggtcc      600

cacaaagagg agccccaaag acaagatgag ccagcagtgc tggagatgga ggacctggac      660

cacctagcca ttcagctggg ggatgggctg gatcctgact ccgtgtctct agcctcggtc      720

accgctctca ccagcaatgt ctccaacaaa cggtctaagc cagatattaa gatggagccc      780

agtgctggaa ggcccatgga ttaccaggtc agcatcacag tgattgaggc tcggcagctg      840

gtgggcttga acatggaccc tgtggtgtgt gtggaggtgg gtgatgacaa gaaatacacg      900

tcaatgaagg agtccacaaa ctgcccttac tacaacgagt actttgtctt cgacttccat      960

gtctctcctg atgtcatgtt tgacaagatc atcaagatct cggttatcca ttctaagaac     1020

ctgcttcgga gcggcaccct ggtgggttcc ttcaaaatgg atgtggggac tgtgtattcc     1080

cagcctgaac accagttcca tcacaaatgg gccatcctgt cagaccccga tgacatctct     1140

gctgggttga agggttatgt aaagtgtgat gtcgctgtgg tgggcaaggg agacaacatc     1200

aagacacccc acaaggccaa cgagacggat gaggacgaca ttgaagggaa cttgctgctc     1260

cccgagggcg tgccccccga acggcagtgg gcacggttct atgtgaaaat ttaccgagca     1320

gagggactgc cccggatgaa cacaagcctc atggccaacg tgaagaaggc gttcatcggt     1380

gagaacaagg acctcgtcga cccctatgtg caagtcttct ttgctggaca aaagggcaaa     1440

acatcagtgc agaagagcag ctatgagccg ctatggaatg agcaggtcgt cttcacagac     1500

ttgttccccc cactctgcaa acgcatgaag gtgcagatcc gggactctga caaggtcaat     1560

gatgtggcca tcggcaccca cttcatcgac ctgcgcaaga tttccaacga tggagacaaa     1620

ggcttcctgc ctaccctcgg tccagcctgg gtgaacatgt acggctccac gcgcaactac     1680

acactgctgg acgagcacca ggacttgaat gaaggcctgg gggagggtgt gtccttccgg     1740

gcccgcctca tgttgggact agctgtggag atcctggaca cctccaaccc agagctcacc     1800

agctccacgg aggtgcaggt ggagcaggcc acgcctgtct cggagagctg cacagggaga     1860

atggaagaat tttttctatt tggagccttc ttggaagcct caatgattga ccggaaaaat     1920

ggggacaagc caattacctt tgaggtgacc ataggaaact acggcaatga agtcgatggt     1980

atgtcccggc ccctgaggcc tcggccccgg aaagagcctg gggatgaaga agaggtagac     2040

ctgattcaga actccagtga cgatgaaggt gacgaagccg gggacctggc ctcggtgtcc     2100

tccaccccac ctatgcggcc ccagatcacg gacaggaact atttccacct gccctacctg     2160

gagcgcaagc cctgcatcta tatcaagagc tggtggcctg accagaggcg gcgcctctac     2220

aatgccaaca tcatggatca cattgctgac aagctggaag aaggcctgaa tgatgtacag     2280

gagatgatca aaacggagaa gtcctacccg gagcgccgcc tgcggggtgt gctagaggaa     2340

ctcagctgtg gctgccaccg cttcctctcc ctctcggaca aggaccaggg ccgctcgtcc     2400

cgcaccaggc tggatcgaga gcgtcttaag tcctgtatga gggagttgga gagcatggga     2460

cagcaggcca agagcctgag ggctcaggtg aagcggcaca ctgttcggga caagctgagg     2520

tcatgccaga actttctgca gaagctacgc ttcctggcgg atgagcccca gcacagcatt     2580

cctgatgtgt tcatttggat gatgagcaac aacaaacgta tcgcctatgc ccgcgtgcct     2640

tccaaagacc tgctcttctc catcgtggag gaggaactgg gcaaggactg cgccaaagtc     2700

aagaccctct tcctgaagct gccagggaag aggggcttcg gctcggcagg ctggacagta     2760

caggccaagc tggagctcta cctgtggctg ggcctcagca agcagcgaaa ggacttcctg     2820

tgtggtctgc cctgtggctt cgaggaggtc aaggcagccc aaggcctggg cctgcattcc     2880

tttccgccca tcagcctagt ctacaccaag aagcaagcct tccagctccg agcacacatg     2940

tatcaggccc gaagcctctt tgctgctgac agcagtgggc tctctgatcc ctttgcccgt     3000

gtcttcttca tcaaccagag ccaatgcact gaggttctaa acgagacact gtgtcccacc     3060

tgggaccaga tgctggtatt tgacaacctg gagctgtacg gtgaagctca cgagttacga     3120

gatgatcccc ccatcattgt cattgaaatc tacgaccagg acagcatggg caaagccgac     3180

ttcatgggcc ggaccttcgc caagcccctg gtgaagatgg cagatgaagc atactgccca     3240

cctcgcttcc cgccgcagct tgagtactac cagatctacc gaggcagtgc cactgccgga     3300

gacctactgg ctgccttcga gctgctgcag attgggccat cagggaaggc tgacctgcca     3360

cccatcaatg gcccagtgga catggacaga gggcccatca tgcctgtgcc cgtgggaatc     3420

cggccagtgc tcagcaagta ccgagtggag gtgctgttct ggggcctgag ggacctaaag     3480

agggtgaacc tggcccaggt ggaccgacca cgggtggaca tcgagtgtgc aggaaagggg     3540

gtacaatcct ccctgattca caattataag aagaacccca acttcaacac gctggtcaag     3600

tggtttgaag tggacctccc ggagaatgag ctcctgcacc cacccttgaa catccgagtg     3660

gtagattgcc gggcctttgg acgatacacc ctggtgggtt cccacgcagt cagctcactg     3720

aggcgcttca tctaccgacc tccagaccgc tcagccccca actggaacac cacaggggag     3780

gttgtagtaa gcatggagcc tgaggagcca gttaagaagc tggagaccat ggtgaaactg     3840

gatgcgactt ctgatgctgt ggtcaaggtg gatgtggctg aagatgagaa ggaaaggaag     3900

aagaagaaaa agaaaggccc gtcagaggag ccagaggagg aagagcccga tgagagcatg     3960

ctggattggt ggtccaagta cttcgcctcc atcgacacaa tgaaggagca acttcgacaa     4020

catgagacct ctggaactga cttggaagag aaggaagaga tggaaagcgc tgagggcctg     4080

aagggaccaa tgaagagcaa ggagaagtcc agagctgcaa aggaggagaa aaagaagaaa     4140

aaccagagcc ctggccctgg ccagggatcg gaggctcctg agaagaagaa agccaagatc     4200

gatgagctta aggtgtaccc caaggagctg gaatcggagt ttgacagctt tgaggactgg     4260

ctgcacacct tcaacctgtt gaggggcaag acgggagatg atgaggatgg ctccacagag     4320

gaggagcgca tagtaggccg attcaagggc tccctctgtg tgtacaaagt gccactccca     4380

gaagatgtat ctcgagaagc tggctatgat cccacctatg gaatgttcca gggcatccca     4440

agcaatgacc ccatcaatgt gctggtccga atctatgtgg tccgggccac agacctgcac     4500

ccggccgaca tcaatggcaa agctgacccc tatattgcca tcaagttagg caagaccgac     4560

atccgagaca aggagaacta catctccaag cagctcaacc ctgtgtttgg gaagtccttt     4620

gacattgagg cctccttccc catggagtcc atgttgacag tggccgtgta cgactgggat     4680

ctggtgggca ctgatgacct catcggagaa accaagattg acctggaaaa ccgcttctac     4740

agcaagcatc gcgccacctg cggcatcgca cagacctatt ccatacatgg ctacaatatc     4800

tggagggacc ccatgaagcc cagccagatc ctgacacgcc tctgtaaaga gggcaaagtg     4860

gacggccccc actttggtcc ccatgggaga gtgagggttg ccaaccgtgt cttcacgggg     4920

ccttcagaaa tagaggatga gaatggtcag aggaagccca cagatgagca cgtggcactg     4980

tctgctctga gacactggga ggacatcccc cgggtgggct gccgccttgt gccggaacac     5040

gtggagacca ggccgctgct caaccctgac aagccaggca ttgagcaggg ccgcctggag     5100

ctgtgggtgg acatgttccc catggacatg ccagcccctg ggacacctct ggatatatcc     5160

cccaggaaac ccaagaagta cgagctgcgg gtcatcgtgt ggaacacaga cgaggtggtc     5220

ctggaagacg atgatttctt cacgggagag aagtccagtg acatttttgt gagggggtgg     5280

ctgaagggcc agcaggagga caaacaggac acagatgtcc actatcactc cctcacgggg     5340

gagggcaact tcaactggag atacctcttc cccttcgact acctagcggc cgaagagaag     5400

atcgttatgt ccaaaaagga gtctatgttc tcctgggatg agacggagta caagatccct     5460

gcgcggctca ccctgcagat ctgggacgct gaccacttct cggctgacga cttcctgggg     5520

gctatcgagc tggacctgaa ccggttcccg aggggcgcta agacagccaa gcagtgcacc     5580

atggagatgg ccaccgggga ggtggacgta cccctggttt ccatctttaa acagaaacgt     5640

gtcaaaggct ggtggcccct cctggcccgc aatgagaatg atgagtttga gctcacaggc     5700

aaagtggagg cggagctaca cctactcacg gcagaggagg cagagaagaa ccctgtgggc     5760

ctggctcgca atgaacctga tcccctagaa aaacccaacc ggcctgacac ggcattcgtc     5820

tggttcctga acccactcaa atctatcaag tacctcatct gcacccggta caagtggctg     5880

atcatcaaga tcgtgctggc gctgctgggg ctgctcatgc tggccctctt cctttacagc     5940

ctcccaggct acatggtcaa gaagctccta ggggcctga                            5979


<210>  13
<211>  1977
<212>  PRT
<213>  Mus musculus

<400>  13

Met Ala Leu Ile Val His Leu Lys Thr Val Ser Glu Leu Arg Gly Lys 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Gly Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Val Leu Glu Ile 
    50                  55                  60                  


Gln Ile Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Cys Met Val Leu Gln Lys Val Val Glu Glu Asn Arg Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Met Asp Asp Ser Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Ser Met Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Pro Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Lys Asp 
    130                 135                 140                 


Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Ser Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe Ser 
                165                 170                 175     


Ala Met Lys Leu Gly Lys Thr Arg Ser His Lys Glu Glu Pro Gln Arg 
            180                 185                 190         


Gln Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu Ala 
        195                 200                 205             


Ile Gln Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala Ser 
    210                 215                 220                 


Val Thr Ala Leu Thr Ser Asn Val Ser Asn Lys Arg Ser Lys Pro Asp 
225                 230                 235                 240 


Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val Ser 
                245                 250                 255     


Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp Pro 
            260                 265                 270         


Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met Lys 
        275                 280                 285             


Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp Phe 
    290                 295                 300                 


His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser Val 
305                 310                 315                 320 


Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser Phe 
                325                 330                 335     


Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe His 
            340                 345                 350         


His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ala Gly Leu 
        355                 360                 365             


Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp Asn 
    370                 375                 380                 


Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile Glu 
385                 390                 395                 400 


Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp Ala 
                405                 410                 415     


Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met Asn 
            420                 425                 430         


Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn Lys 
        435                 440                 445             


Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys Gly 
    450                 455                 460                 


Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu Gln 
465                 470                 475                 480 


Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys Val 
                485                 490                 495     


Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His 
            500                 505                 510         


Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe Leu 
        515                 520                 525             


Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg Asn 
    530                 535                 540                 


Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly Glu 
545                 550                 555                 560 


Gly Val Ser Phe Arg Ala Arg Leu Met Leu Gly Leu Ala Val Glu Ile 
                565                 570                 575     


Leu Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln Val 
            580                 585                 590         


Glu Gln Ala Thr Pro Val Ser Glu Ser Cys Thr Gly Arg Met Glu Glu 
        595                 600                 605             


Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg Lys 
    610                 615                 620                 


Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr Gly 
625                 630                 635                 640 


Asn Glu Val Asp Gly Met Ser Arg Pro Leu Arg Pro Arg Pro Arg Lys 
                645                 650                 655     


Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ser Ser Asp 
            660                 665                 670         


Asp Glu Gly Asp Glu Ala Gly Asp Leu Ala Ser Val Ser Ser Thr Pro 
        675                 680                 685             


Pro Met Arg Pro Gln Ile Thr Asp Arg Asn Tyr Phe His Leu Pro Tyr 
    690                 695                 700                 


Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp Gln 
705                 710                 715                 720 


Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp Lys 
                725                 730                 735     


Leu Glu Glu Gly Leu Asn Asp Val Gln Glu Met Ile Lys Thr Glu Lys 
            740                 745                 750         


Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys 
        755                 760                 765             


Gly Cys His Arg Phe Leu Ser Leu Ser Asp Lys Asp Gln Gly Arg Ser 
    770                 775                 780                 


Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu 
785                 790                 795                 800 


Leu Glu Ser Met Gly Gln Gln Ala Lys Ser Leu Arg Ala Gln Val Lys 
                805                 810                 815     


Arg His Thr Val Arg Asp Lys Leu Arg Ser Cys Gln Asn Phe Leu Gln 
            820                 825                 830         


Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Val 
        835                 840                 845             


Phe Ile Trp Met Met Ser Asn Asn Lys Arg Ile Ala Tyr Ala Arg Val 
    850                 855                 860                 


Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Leu Gly Lys 
865                 870                 875                 880 


Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg 
                885                 890                 895     


Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Leu Glu Leu Tyr 
            900                 905                 910         


Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Asp Phe Leu Cys Gly Leu 
        915                 920                 925             


Pro Cys Gly Phe Glu Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His 
    930                 935                 940                 


Ser Phe Pro Pro Ile Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln 
945                 950                 955                 960 


Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser 
                965                 970                 975     


Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln Ser 
            980                 985                 990         


Gln Cys Thr Glu Val Leu Asn Glu  Thr Leu Cys Pro Thr  Trp Asp Gln 
        995                 1000                 1005             


Met Leu  Val Phe Asp Asn Leu  Glu Leu Tyr Gly Glu  Ala His Glu 
    1010                 1015                 1020             


Leu Arg  Asp Asp Pro Pro Ile  Ile Val Ile Glu Ile  Tyr Asp Gln 
    1025                 1030                 1035             


Asp Ser  Met Gly Lys Ala Asp  Phe Met Gly Arg Thr  Phe Ala Lys 
    1040                 1045                 1050             


Pro Leu  Val Lys Met Ala Asp  Glu Ala Tyr Cys Pro  Pro Arg Phe 
    1055                 1060                 1065             


Pro Pro  Gln Leu Glu Tyr Tyr  Gln Ile Tyr Arg Gly  Ser Ala Thr 
    1070                 1075                 1080             


Ala Gly  Asp Leu Leu Ala Ala  Phe Glu Leu Leu Gln  Ile Gly Pro 
    1085                 1090                 1095             


Ser Gly  Lys Ala Asp Leu Pro  Pro Ile Asn Gly Pro  Val Asp Met 
    1100                 1105                 1110             


Asp Arg  Gly Pro Ile Met Pro  Val Pro Val Gly Ile  Arg Pro Val 
    1115                 1120                 1125             


Leu Ser  Lys Tyr Arg Val Glu  Val Leu Phe Trp Gly  Leu Arg Asp 
    1130                 1135                 1140             


Leu Lys  Arg Val Asn Leu Ala  Gln Val Asp Arg Pro  Arg Val Asp 
    1145                 1150                 1155             


Ile Glu  Cys Ala Gly Lys Gly  Val Gln Ser Ser Leu  Ile His Asn 
    1160                 1165                 1170             


Tyr Lys  Lys Asn Pro Asn Phe  Asn Thr Leu Val Lys  Trp Phe Glu 
    1175                 1180                 1185             


Val Asp  Leu Pro Glu Asn Glu  Leu Leu His Pro Pro  Leu Asn Ile 
    1190                 1195                 1200             


Arg Val  Val Asp Cys Arg Ala  Phe Gly Arg Tyr Thr  Leu Val Gly 
    1205                 1210                 1215             


Ser His  Ala Val Ser Ser Leu  Arg Arg Phe Ile Tyr  Arg Pro Pro 
    1220                 1225                 1230             


Asp Arg  Ser Ala Pro Asn Trp  Asn Thr Thr Gly Glu  Val Val Val 
    1235                 1240                 1245             


Ser Met  Glu Pro Glu Glu Pro  Val Lys Lys Leu Glu  Thr Met Val 
    1250                 1255                 1260             


Lys Leu  Asp Ala Thr Ser Asp  Ala Val Val Lys Val  Asp Val Ala 
    1265                 1270                 1275             


Glu Asp  Glu Lys Glu Arg Lys  Lys Lys Lys Lys Lys  Gly Pro Ser 
    1280                 1285                 1290             


Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu Ser Met  Leu Asp Trp 
    1295                 1300                 1305             


Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr Met Lys  Glu Gln Leu 
    1310                 1315                 1320             


Arg Gln  His Glu Thr Ser Gly  Thr Asp Leu Glu Glu  Lys Glu Glu 
    1325                 1330                 1335             


Met Glu  Ser Ala Glu Gly Leu  Lys Gly Pro Met Lys  Ser Lys Glu 
    1340                 1345                 1350             


Lys Ser  Arg Ala Ala Lys Glu  Glu Lys Lys Lys Lys  Asn Gln Ser 
    1355                 1360                 1365             


Pro Gly  Pro Gly Gln Gly Ser  Glu Ala Pro Glu Lys  Lys Lys Ala 
    1370                 1375                 1380             


Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys Glu Leu  Glu Ser Glu 
    1385                 1390                 1395             


Phe Asp  Ser Phe Glu Asp Trp  Leu His Thr Phe Asn  Leu Leu Arg 
    1400                 1405                 1410             


Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser Thr Glu  Glu Glu Arg 
    1415                 1420                 1425             


Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys Val Tyr  Lys Val Pro 
    1430                 1435                 1440             


Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly Tyr Asp  Pro Thr Tyr 
    1445                 1450                 1455             


Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp Pro Ile  Asn Val Leu 
    1460                 1465                 1470             


Val Arg  Ile Tyr Val Val Arg  Ala Thr Asp Leu His  Pro Ala Asp 
    1475                 1480                 1485             


Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala Ile Lys  Leu Gly Lys 
    1490                 1495                 1500             


Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile Ser Lys  Gln Leu Asn 
    1505                 1510                 1515             


Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu Ala Ser  Phe Pro Met 
    1520                 1525                 1530             


Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp Trp Asp  Leu Val Gly 
    1535                 1540                 1545             


Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile Asp Leu  Glu Asn Arg 
    1550                 1555                 1560             


Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly Ile Ala  Gln Thr Tyr 
    1565                 1570                 1575             


Ser Ile  His Gly Tyr Asn Ile  Trp Arg Asp Pro Met  Lys Pro Ser 
    1580                 1585                 1590             


Gln Ile  Leu Thr Arg Leu Cys  Lys Glu Gly Lys Val  Asp Gly Pro 
    1595                 1600                 1605             


His Phe  Gly Pro His Gly Arg  Val Arg Val Ala Asn  Arg Val Phe 
    1610                 1615                 1620             


Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn Gly Gln  Arg Lys Pro 
    1625                 1630                 1635             


Thr Asp  Glu His Val Ala Leu  Ser Ala Leu Arg His  Trp Glu Asp 
    1640                 1645                 1650             


Ile Pro  Arg Val Gly Cys Arg  Leu Val Pro Glu His  Val Glu Thr 
    1655                 1660                 1665             


Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly Ile Glu  Gln Gly Arg 
    1670                 1675                 1680             


Leu Glu  Leu Trp Val Asp Met  Phe Pro Met Asp Met  Pro Ala Pro 
    1685                 1690                 1695             


Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys Pro Lys  Lys Tyr Glu 
    1700                 1705                 1710             


Leu Arg  Val Ile Val Trp Asn  Thr Asp Glu Val Val  Leu Glu Asp 
    1715                 1720                 1725             


Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser Asp Ile  Phe Val Arg 
    1730                 1735                 1740             


Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys Gln Asp  Thr Asp Val 
    1745                 1750                 1755             


His Tyr  His Ser Leu Thr Gly  Glu Gly Asn Phe Asn  Trp Arg Tyr 
    1760                 1765                 1770             


Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu Glu Lys  Ile Val Met 
    1775                 1780                 1785             


Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp Glu Thr  Glu Tyr Lys 
    1790                 1795                 1800             


Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp Asp Ala  Asp His Phe 
    1805                 1810                 1815             


Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu Leu Asp  Leu Asn Arg 
    1820                 1825                 1830             


Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln Cys Thr  Met Glu Met 
    1835                 1840                 1845             


Ala Thr  Gly Glu Val Asp Val  Pro Leu Val Ser Ile  Phe Lys Gln 
    1850                 1855                 1860             


Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu Ala Arg  Asn Glu Asn 
    1865                 1870                 1875             


Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu Ala Glu  Leu His Leu 
    1880                 1885                 1890             


Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro Val Gly  Leu Ala Arg 
    1895                 1900                 1905             


Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn Arg Pro  Asp Thr Ser 
    1910                 1915                 1920             


Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser Ala Arg  Tyr Phe Leu 
    1925                 1930                 1935             


Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys Phe Leu  Leu Leu Phe 
    1940                 1945                 1950             


Leu Leu  Leu Leu Leu Phe Ala  Leu Phe Leu Tyr Ser  Leu Pro Gly 
    1955                 1960                 1965             


Tyr Leu  Ala Lys Lys Ile Leu  Gly Ala 
    1970                 1975         


<210>  14
<211>  5934
<212>  DNA
<213>  Mus musculus

<400>  14
atggccctga ttgttcacct caagactgtc tcagagctcc gaggcaaagg tgaccggatt       60

gccaaagtca ctttccgagg gcagtctttc tactcccggg tcctggagaa ctgcgagggt      120

gtggctgact ttgatgagac gttccggtgg ccagtggcca gcagcatcga ccggaatgaa      180

gtgttggaga ttcagatttt caactacagc aaagtcttca gcaacaagct gatagggacc      240

ttctgcatgg tgctgcagaa agtggtggag gagaatcggg tagaggtgac cgacacgctg      300

atggatgaca gcaatgctat catcaagacc agcctgagca tggaggtccg gtatcaggcc      360

acagatggca ctgtgggccc ctgggatgat ggagacttcc tgggagatga atccctccag      420

gaggagaagg acagccagga gacagatggg ctgctacctg gttcccgacc cagcacccgg      480

atatctggcg agaagagctt tcgcagagcg ggaaggagtg tgttctcggc catgaaactc      540

ggcaaaactc ggtcccacaa agaggagccc caaagacaag atgagccagc agtgctggag      600

atggaggacc tggaccacct agccattcag ctgggggatg ggctggatcc tgactccgtg      660

tctctagcct cggtcaccgc tctcaccagc aatgtctcca acaaacggtc taagccagat      720

attaagatgg agcccagtgc tggaaggccc atggattacc aggtcagcat cacagtgatt      780

gaggctcggc agctggtggg cttgaacatg gaccctgtgg tgtgtgtgga ggtgggtgat      840

gacaagaaat acacgtcaat gaaggagtcc acaaactgcc cttactacaa cgagtacttt      900

gtcttcgact tccatgtctc tcctgatgtc atgtttgaca agatcatcaa gatctcggtt      960

atccattcta agaacctgct tcggagcggc accctggtgg gttccttcaa aatggatgtg     1020

gggactgtgt attcccagcc tgaacaccag ttccatcaca aatgggccat cctgtcagac     1080

cccgatgaca tctctgctgg gttgaagggt tatgtaaagt gtgatgtcgc tgtggtgggc     1140

aagggagaca acatcaagac accccacaag gccaacgaga cggatgagga cgacattgaa     1200

gggaacttgc tgctccccga gggcgtgccc cccgaacggc agtgggcacg gttctatgtg     1260

aaaatttacc gagcagaggg actgccccgg atgaacacaa gcctcatggc caacgtgaag     1320

aaggcgttca tcggtgagaa caaggacctc gtcgacccct atgtgcaagt cttctttgct     1380

ggacaaaagg gcaaaacatc agtgcagaag agcagctatg agccgctatg gaatgagcag     1440

gtcgtcttca cagacttgtt ccccccactc tgcaaacgca tgaaggtgca gatccgggac     1500

tctgacaagg tcaatgatgt ggccatcggc acccacttca tcgacctgcg caagatttcc     1560

aacgatggag acaaaggctt cctgcctacc ctcggtccag cctgggtgaa catgtacggc     1620

tccacgcgca actacacact gctggacgag caccaggact tgaatgaagg cctgggggag     1680

ggtgtgtcct tccgggcccg cctcatgttg ggactagctg tggagatcct ggacacctcc     1740

aacccagagc tcaccagctc cacggaggtg caggtggagc aggccacgcc tgtctcggag     1800

agctgcacag ggagaatgga agaatttttt ctatttggag ccttcttgga agcctcaatg     1860

attgaccgga aaaatgggga caagccaatt acctttgagg tgaccatagg aaactacggc     1920

aatgaagtcg atggtatgtc ccggcccctg aggcctcggc cccggaaaga gcctggggat     1980

gaagaagagg tagacctgat tcagaactcc agtgacgatg aaggtgacga agccggggac     2040

ctggcctcgg tgtcctccac cccacctatg cggccccaga tcacggacag gaactatttc     2100

cacctgccct acctggagcg caagccctgc atctatatca agagctggtg gcctgaccag     2160

aggcggcgcc tctacaatgc caacatcatg gatcacattg ctgacaagct ggaagaaggc     2220

ctgaatgatg tacaggagat gatcaaaacg gagaagtcct acccggagcg ccgcctgcgg     2280

ggtgtgctag aggaactcag ctgtggctgc caccgcttcc tctccctctc ggacaaggac     2340

cagggccgct cgtcccgcac caggctggat cgagagcgtc ttaagtcctg tatgagggag     2400

ttggagagca tgggacagca ggccaagagc ctgagggctc aggtgaagcg gcacactgtt     2460

cgggacaagc tgaggtcatg ccagaacttt ctgcagaagc tacgcttcct ggcggatgag     2520

ccccagcaca gcattcctga tgtgttcatt tggatgatga gcaacaacaa acgtatcgcc     2580

tatgcccgcg tgccttccaa agacctgctc ttctccatcg tggaggagga actgggcaag     2640

gactgcgcca aagtcaagac cctcttcctg aagctgccag ggaagagggg cttcggctcg     2700

gcaggctgga cagtacaggc caagctggag ctctacctgt ggctgggcct cagcaagcag     2760

cgaaaggact tcctgtgtgg tctgccctgt ggcttcgagg aggtcaaggc agcccaaggc     2820

ctgggcctgc attcctttcc gcccatcagc ctagtctaca ccaagaagca agccttccag     2880

ctccgagcac acatgtatca ggcccgaagc ctctttgctg ctgacagcag tgggctctct     2940

gatccctttg cccgtgtctt cttcatcaac cagagccaat gcactgaggt tctaaacgag     3000

acactgtgtc ccacctggga ccagatgctg gtatttgaca acctggagct gtacggtgaa     3060

gctcacgagt tacgagatga tccccccatc attgtcattg aaatctacga ccaggacagc     3120

atgggcaaag ccgacttcat gggccggacc ttcgccaagc ccctggtgaa gatggcagat     3180

gaagcatact gcccacctcg cttcccgccg cagcttgagt actaccagat ctaccgaggc     3240

agtgccactg ccggagacct actggctgcc ttcgagctgc tgcagattgg gccatcaggg     3300

aaggctgacc tgccacccat caatggccca gtggacatgg acagagggcc catcatgcct     3360

gtgcccgtgg gaatccggcc agtgctcagc aagtaccgag tggaggtgct gttctggggc     3420

ctgagggacc taaagagggt gaacctggcc caggtggacc gaccacgggt ggacatcgag     3480

tgtgcaggaa agggggtaca atcctccctg attcacaatt ataagaagaa ccccaacttc     3540

aacacgctgg tcaagtggtt tgaagtggac ctcccggaga atgagctcct gcacccaccc     3600

ttgaacatcc gagtggtaga ttgccgggcc tttggacgat acaccctggt gggttcccac     3660

gcagtcagct cactgaggcg cttcatctac cgacctccag accgctcagc ccccaactgg     3720

aacaccacag gggaggttgt agtaagcatg gagcctgagg agccagttaa gaagctggag     3780

accatggtga aactggatgc gacttctgat gctgtggtca aggtggatgt ggctgaagat     3840

gagaaggaaa ggaagaagaa gaaaaagaaa ggcccgtcag aggagccaga ggaggaagag     3900

cccgatgaga gcatgctgga ttggtggtcc aagtacttcg cctccatcga cacaatgaag     3960

gagcaacttc gacaacatga gacctctgga actgacttgg aagagaagga agagatggaa     4020

agcgctgagg gcctgaaggg accaatgaag agcaaggaga agtccagagc tgcaaaggag     4080

gagaaaaaga agaaaaacca gagccctggc cctggccagg gatcggaggc tcctgagaag     4140

aagaaagcca agatcgatga gcttaaggtg taccccaagg agctggaatc ggagtttgac     4200

agctttgagg actggctgca caccttcaac ctgttgaggg gcaagacggg agatgatgag     4260

gatggctcca cagaggagga gcgcatagta ggccgattca agggctccct ctgtgtgtac     4320

aaagtgccac tcccagaaga tgtatctcga gaagctggct atgatcccac ctatggaatg     4380

ttccagggca tcccaagcaa tgaccccatc aatgtgctgg tccgaatcta tgtggtccgg     4440

gccacagacc tgcacccggc cgacatcaat ggcaaagctg acccctatat tgccatcaag     4500

ttaggcaaga ccgacatccg agacaaggag aactacatct ccaagcagct caaccctgtg     4560

tttgggaagt cctttgacat tgaggcctcc ttccccatgg agtccatgtt gacagtggcc     4620

gtgtacgact gggatctggt gggcactgat gacctcatcg gagaaaccaa gattgacctg     4680

gaaaaccgct tctacagcaa gcatcgcgcc acctgcggca tcgcacagac ctattccata     4740

catggctaca atatctggag ggaccccatg aagcccagcc agatcctgac acgcctctgt     4800

aaagagggca aagtggacgg cccccacttt ggtccccatg ggagagtgag ggttgccaac     4860

cgtgtcttca cggggccttc agaaatagag gatgagaatg gtcagaggaa gcccacagat     4920

gagcacgtgg cactgtctgc tctgagacac tgggaggaca tcccccgggt gggctgccgc     4980

cttgtgccgg aacacgtgga gaccaggccg ctgctcaacc ctgacaagcc aggcattgag     5040

cagggccgcc tggagctgtg ggtggacatg ttccccatgg acatgccagc ccctgggaca     5100

cctctggata tatcccccag gaaacccaag aagtacgagc tgcgggtcat cgtgtggaac     5160

acagacgagg tggtcctgga agacgatgat ttcttcacgg gagagaagtc cagtgacatt     5220

tttgtgaggg ggtggctgaa gggccagcag gaggacaaac aggacacaga tgtccactat     5280

cactccctca cgggggaggg caacttcaac tggagatacc tcttcccctt cgactaccta     5340

gcggccgaag agaagatcgt tatgtccaaa aaggagtcta tgttctcctg ggatgagacg     5400

gagtacaaga tccctgcgcg gctcaccctg cagatctggg acgctgacca cttctcggct     5460

gacgacttcc tgggggctat cgagctggac ctgaaccggt tcccgagggg cgctaagaca     5520

gccaagcagt gcaccatgga gatggccacc ggggaggtgg acgtacccct ggtttccatc     5580

tttaaacaga aacgtgtcaa aggctggtgg cccctcctgg cccgcaatga gaatgatgag     5640

tttgagctca caggcaaagt ggaggcggag ctacacctac tcacggcaga ggaggcagag     5700

aagaaccctg tgggcctggc tcgcaatgaa cctgatcccc tagaaaaacc caatcggccg     5760

gacacaagct tcatctggtt cttgaaccct ctcaagtctg cccgctactt cctgtggcat     5820

acctaccgct ggctactcct caaattcctg ctgctcttcc tcctgctgct gctcttcgcc     5880

ctgtttctct actctctgcc tggctacctg gccaagaaga tccttggggc ctga           5934


<210>  15
<211>  1977
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ala Leu Ile Val His Leu Lys Thr Val Ser Glu Leu Arg Gly Lys 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Gly Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Val Leu Glu Ile 
    50                  55                  60                  


Gln Ile Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Cys Met Val Leu Gln Lys Val Val Glu Glu Asn Arg Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Met Asp Asp Ser Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Ser Met Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Pro Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Lys Asp 
    130                 135                 140                 


Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Ser Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe Ser 
                165                 170                 175     


Ala Met Lys Leu Gly Lys Thr Arg Ser His Lys Glu Glu Pro Gln Arg 
            180                 185                 190         


Gln Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu Ala 
        195                 200                 205             


Ile Gln Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala Ser 
    210                 215                 220                 


Val Thr Ala Leu Thr Ser Asn Val Ser Asn Lys Arg Ser Lys Pro Asp 
225                 230                 235                 240 


Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val Ser 
                245                 250                 255     


Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp Pro 
            260                 265                 270         


Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met Lys 
        275                 280                 285             


Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp Phe 
    290                 295                 300                 


His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser Val 
305                 310                 315                 320 


Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser Phe 
                325                 330                 335     


Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe His 
            340                 345                 350         


His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ala Gly Leu 
        355                 360                 365             


Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp Asn 
    370                 375                 380                 


Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile Glu 
385                 390                 395                 400 


Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp Ala 
                405                 410                 415     


Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met Asn 
            420                 425                 430         


Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn Lys 
        435                 440                 445             


Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys Gly 
    450                 455                 460                 


Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu Gln 
465                 470                 475                 480 


Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys Val 
                485                 490                 495     


Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His 
            500                 505                 510         


Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe Leu 
        515                 520                 525             


Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg Asn 
    530                 535                 540                 


Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly Glu 
545                 550                 555                 560 


Gly Val Ser Phe Arg Ala Arg Leu Met Leu Gly Leu Ala Val Glu Ile 
                565                 570                 575     


Leu Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln Val 
            580                 585                 590         


Glu Gln Ala Thr Pro Val Ser Glu Ser Cys Thr Gly Arg Met Glu Glu 
        595                 600                 605             


Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg Lys 
    610                 615                 620                 


Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr Gly 
625                 630                 635                 640 


Asn Glu Val Asp Gly Met Ser Arg Pro Leu Arg Pro Arg Pro Arg Lys 
                645                 650                 655     


Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ser Ser Asp 
            660                 665                 670         


Asp Glu Gly Asp Glu Ala Gly Asp Leu Ala Ser Val Ser Ser Thr Pro 
        675                 680                 685             


Pro Met Arg Pro Gln Ile Thr Asp Arg Asn Tyr Phe His Leu Pro Tyr 
    690                 695                 700                 


Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp Gln 
705                 710                 715                 720 


Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp Lys 
                725                 730                 735     


Leu Glu Glu Gly Leu Asn Asp Val Gln Glu Met Ile Lys Thr Glu Lys 
            740                 745                 750         


Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys 
        755                 760                 765             


Gly Cys His Arg Phe Leu Ser Leu Ser Asp Lys Asp Gln Gly Arg Ser 
    770                 775                 780                 


Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu 
785                 790                 795                 800 


Leu Glu Ser Met Gly Gln Gln Ala Lys Ser Leu Arg Ala Gln Val Lys 
                805                 810                 815     


Arg His Thr Val Arg Asp Lys Leu Arg Ser Cys Gln Asn Phe Leu Gln 
            820                 825                 830         


Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Val 
        835                 840                 845             


Phe Ile Trp Met Met Ser Asn Asn Lys Arg Ile Ala Tyr Ala Arg Val 
    850                 855                 860                 


Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Leu Gly Lys 
865                 870                 875                 880 


Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg 
                885                 890                 895     


Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Leu Glu Leu Tyr 
            900                 905                 910         


Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Asp Phe Leu Cys Gly Leu 
        915                 920                 925             


Pro Cys Gly Phe Glu Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His 
    930                 935                 940                 


Ser Phe Pro Pro Ile Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln 
945                 950                 955                 960 


Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser 
                965                 970                 975     


Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln Ser 
            980                 985                 990         


Gln Cys Thr Glu Val Leu Asn Glu  Thr Leu Cys Pro Thr  Trp Asp Gln 
        995                 1000                 1005             


Met Leu  Val Phe Asp Asn Leu  Glu Leu Tyr Gly Glu  Ala His Glu 
    1010                 1015                 1020             


Leu Arg  Asp Asp Pro Pro Ile  Ile Val Ile Glu Ile  Tyr Asp Gln 
    1025                 1030                 1035             


Asp Ser  Met Gly Lys Ala Asp  Phe Met Gly Arg Thr  Phe Ala Lys 
    1040                 1045                 1050             


Pro Leu  Val Lys Met Ala Asp  Glu Ala Tyr Cys Pro  Pro Arg Phe 
    1055                 1060                 1065             


Pro Pro  Gln Leu Glu Tyr Tyr  Gln Ile Tyr Arg Gly  Ser Ala Thr 
    1070                 1075                 1080             


Ala Gly  Asp Leu Leu Ala Ala  Phe Glu Leu Leu Gln  Ile Gly Pro 
    1085                 1090                 1095             


Ser Gly  Lys Ala Asp Leu Pro  Pro Ile Asn Gly Pro  Val Asp Met 
    1100                 1105                 1110             


Asp Arg  Gly Pro Ile Met Pro  Val Pro Val Gly Ile  Arg Pro Val 
    1115                 1120                 1125             


Leu Ser  Lys Tyr Arg Val Glu  Val Leu Phe Trp Gly  Leu Arg Asp 
    1130                 1135                 1140             


Leu Lys  Arg Val Asn Leu Ala  Gln Val Asp Arg Pro  Arg Val Asp 
    1145                 1150                 1155             


Ile Glu  Cys Ala Gly Lys Gly  Val Gln Ser Ser Leu  Ile His Asn 
    1160                 1165                 1170             


Tyr Lys  Lys Asn Pro Asn Phe  Asn Thr Leu Val Lys  Trp Phe Glu 
    1175                 1180                 1185             


Val Asp  Leu Pro Glu Asn Glu  Leu Leu His Pro Pro  Leu Asn Ile 
    1190                 1195                 1200             


Arg Val  Val Asp Cys Arg Ala  Phe Gly Arg Tyr Thr  Leu Val Gly 
    1205                 1210                 1215             


Ser His  Ala Val Ser Ser Leu  Arg Arg Phe Ile Tyr  Arg Pro Pro 
    1220                 1225                 1230             


Asp Arg  Ser Ala Pro Asn Trp  Asn Thr Thr Gly Glu  Val Val Val 
    1235                 1240                 1245             


Ser Met  Glu Pro Glu Glu Pro  Val Lys Lys Leu Glu  Thr Met Val 
    1250                 1255                 1260             


Lys Leu  Asp Ala Thr Ser Asp  Ala Val Val Lys Val  Asp Val Ala 
    1265                 1270                 1275             


Glu Asp  Glu Lys Glu Arg Lys  Lys Lys Lys Lys Lys  Gly Pro Ser 
    1280                 1285                 1290             


Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu Ser Met  Leu Asp Trp 
    1295                 1300                 1305             


Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr Met Lys  Glu Gln Leu 
    1310                 1315                 1320             


Arg Gln  His Glu Thr Ser Gly  Thr Asp Leu Glu Glu  Lys Glu Glu 
    1325                 1330                 1335             


Met Glu  Ser Ala Glu Gly Leu  Lys Gly Pro Met Lys  Ser Lys Glu 
    1340                 1345                 1350             


Lys Ser  Arg Ala Ala Lys Glu  Glu Lys Lys Lys Lys  Asn Gln Ser 
    1355                 1360                 1365             


Pro Gly  Pro Gly Gln Gly Ser  Glu Ala Pro Glu Lys  Lys Lys Ala 
    1370                 1375                 1380             


Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys Glu Leu  Glu Ser Glu 
    1385                 1390                 1395             


Phe Asp  Ser Phe Glu Asp Trp  Leu His Thr Phe Asn  Leu Leu Arg 
    1400                 1405                 1410             


Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser Thr Glu  Glu Glu Arg 
    1415                 1420                 1425             


Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys Val Tyr  Lys Val Pro 
    1430                 1435                 1440             


Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly Tyr Asp  Pro Thr Tyr 
    1445                 1450                 1455             


Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp Pro Ile  Asn Val Leu 
    1460                 1465                 1470             


Val Arg  Ile Tyr Val Val Arg  Ala Thr Asp Leu His  Pro Ala Asp 
    1475                 1480                 1485             


Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala Ile Lys  Leu Gly Lys 
    1490                 1495                 1500             


Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile Ser Lys  Gln Leu Asn 
    1505                 1510                 1515             


Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu Ala Ser  Phe Pro Met 
    1520                 1525                 1530             


Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp Trp Asp  Leu Val Gly 
    1535                 1540                 1545             


Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile Asp Leu  Glu Asn Arg 
    1550                 1555                 1560             


Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly Ile Ala  Gln Thr Tyr 
    1565                 1570                 1575             


Ser Ile  His Gly Tyr Asn Ile  Trp Arg Asp Pro Met  Lys Pro Ser 
    1580                 1585                 1590             


Gln Ile  Leu Thr Arg Leu Cys  Lys Glu Gly Lys Val  Asp Gly Pro 
    1595                 1600                 1605             


His Phe  Gly Pro His Gly Arg  Val Arg Val Ala Asn  Arg Val Phe 
    1610                 1615                 1620             


Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn Gly Gln  Arg Lys Pro 
    1625                 1630                 1635             


Thr Asp  Glu His Val Ala Leu  Ser Ala Leu Arg His  Trp Glu Asp 
    1640                 1645                 1650             


Ile Pro  Arg Val Gly Cys Arg  Leu Val Pro Glu His  Val Glu Thr 
    1655                 1660                 1665             


Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly Ile Glu  Gln Gly Arg 
    1670                 1675                 1680             


Leu Glu  Leu Trp Val Asp Met  Phe Pro Met Asp Met  Pro Ala Pro 
    1685                 1690                 1695             


Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys Pro Lys  Lys Tyr Glu 
    1700                 1705                 1710             


Leu Arg  Val Ile Val Trp Asn  Thr Asp Glu Val Val  Leu Glu Asp 
    1715                 1720                 1725             


Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser Asp Ile  Phe Val Arg 
    1730                 1735                 1740             


Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys Gln Asp  Thr Asp Val 
    1745                 1750                 1755             


His Tyr  His Ser Leu Thr Gly  Glu Gly Asn Phe Asn  Trp Arg Tyr 
    1760                 1765                 1770             


Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu Glu Lys  Ile Val Met 
    1775                 1780                 1785             


Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp Glu Thr  Glu Tyr Lys 
    1790                 1795                 1800             


Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp Asp Ala  Asp His Phe 
    1805                 1810                 1815             


Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu Leu Asp  Leu Asn Arg 
    1820                 1825                 1830             


Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln Cys Thr  Met Glu Met 
    1835                 1840                 1845             


Ala Thr  Gly Glu Val Asp Val  Pro Leu Val Ser Ile  Phe Lys Gln 
    1850                 1855                 1860             


Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu Ala Arg  Asn Glu Asn 
    1865                 1870                 1875             


Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu Ala Glu  Leu His Leu 
    1880                 1885                 1890             


Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro Val Gly  Leu Ala Arg 
    1895                 1900                 1905             


Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn Arg Pro  Asp Thr Ala 
    1910                 1915                 1920             


Phe Val  Trp Phe Leu Asn Pro  Leu Lys Ser Ile Lys  Tyr Leu Ile 
    1925                 1930                 1935             


Cys Thr  Arg Tyr Lys Trp Leu  Ile Ile Lys Ile Val  Leu Ala Leu 
    1940                 1945                 1950             


Leu Gly  Leu Leu Met Leu Ala  Leu Phe Leu Tyr Ser  Leu Pro Gly 
    1955                 1960                 1965             


Tyr Met  Val Lys Lys Leu Leu  Gly Ala 
    1970                 1975         


<210>  16
<211>  5934
<212>  DNA
<213>  Mus musculus

<400>  16
atggccctga ttgttcacct caagactgtc tcagagctcc gaggcaaagg tgaccggatt       60

gccaaagtca ctttccgagg gcagtctttc tactcccggg tcctggagaa ctgcgagggt      120

gtggctgact ttgatgagac gttccggtgg ccagtggcca gcagcatcga ccggaatgaa      180

gtgttggaga ttcagatttt caactacagc aaagtcttca gcaacaagct gatagggacc      240

ttctgcatgg tgctgcagaa agtggtggag gagaatcggg tagaggtgac cgacacgctg      300

atggatgaca gcaatgctat catcaagacc agcctgagca tggaggtccg gtatcaggcc      360

acagatggca ctgtgggccc ctgggatgat ggagacttcc tgggagatga atccctccag      420

gaggagaagg acagccagga gacagatggg ctgctacctg gttcccgacc cagcacccgg      480

atatctggcg agaagagctt tcgcagagcg ggaaggagtg tgttctcggc catgaaactc      540

ggcaaaactc ggtcccacaa agaggagccc caaagacaag atgagccagc agtgctggag      600

atggaggacc tggaccacct agccattcag ctgggggatg ggctggatcc tgactccgtg      660

tctctagcct cggtcaccgc tctcaccagc aatgtctcca acaaacggtc taagccagat      720

attaagatgg agcccagtgc tggaaggccc atggattacc aggtcagcat cacagtgatt      780

gaggctcggc agctggtggg cttgaacatg gaccctgtgg tgtgtgtgga ggtgggtgat      840

gacaagaaat acacgtcaat gaaggagtcc acaaactgcc cttactacaa cgagtacttt      900

gtcttcgact tccatgtctc tcctgatgtc atgtttgaca agatcatcaa gatctcggtt      960

atccattcta agaacctgct tcggagcggc accctggtgg gttccttcaa aatggatgtg     1020

gggactgtgt attcccagcc tgaacaccag ttccatcaca aatgggccat cctgtcagac     1080

cccgatgaca tctctgctgg gttgaagggt tatgtaaagt gtgatgtcgc tgtggtgggc     1140

aagggagaca acatcaagac accccacaag gccaacgaga cggatgagga cgacattgaa     1200

gggaacttgc tgctccccga gggcgtgccc cccgaacggc agtgggcacg gttctatgtg     1260

aaaatttacc gagcagaggg actgccccgg atgaacacaa gcctcatggc caacgtgaag     1320

aaggcgttca tcggtgagaa caaggacctc gtcgacccct atgtgcaagt cttctttgct     1380

ggacaaaagg gcaaaacatc agtgcagaag agcagctatg agccgctatg gaatgagcag     1440

gtcgtcttca cagacttgtt ccccccactc tgcaaacgca tgaaggtgca gatccgggac     1500

tctgacaagg tcaatgatgt ggccatcggc acccacttca tcgacctgcg caagatttcc     1560

aacgatggag acaaaggctt cctgcctacc ctcggtccag cctgggtgaa catgtacggc     1620

tccacgcgca actacacact gctggacgag caccaggact tgaatgaagg cctgggggag     1680

ggtgtgtcct tccgggcccg cctcatgttg ggactagctg tggagatcct ggacacctcc     1740

aacccagagc tcaccagctc cacggaggtg caggtggagc aggccacgcc tgtctcggag     1800

agctgcacag ggagaatgga agaatttttt ctatttggag ccttcttgga agcctcaatg     1860

attgaccgga aaaatgggga caagccaatt acctttgagg tgaccatagg aaactacggc     1920

aatgaagtcg atggtatgtc ccggcccctg aggcctcggc cccggaaaga gcctggggat     1980

gaagaagagg tagacctgat tcagaactcc agtgacgatg aaggtgacga agccggggac     2040

ctggcctcgg tgtcctccac cccacctatg cggccccaga tcacggacag gaactatttc     2100

cacctgccct acctggagcg caagccctgc atctatatca agagctggtg gcctgaccag     2160

aggcggcgcc tctacaatgc caacatcatg gatcacattg ctgacaagct ggaagaaggc     2220

ctgaatgatg tacaggagat gatcaaaacg gagaagtcct acccggagcg ccgcctgcgg     2280

ggtgtgctag aggaactcag ctgtggctgc caccgcttcc tctccctctc ggacaaggac     2340

cagggccgct cgtcccgcac caggctggat cgagagcgtc ttaagtcctg tatgagggag     2400

ttggagagca tgggacagca ggccaagagc ctgagggctc aggtgaagcg gcacactgtt     2460

cgggacaagc tgaggtcatg ccagaacttt ctgcagaagc tacgcttcct ggcggatgag     2520

ccccagcaca gcattcctga tgtgttcatt tggatgatga gcaacaacaa acgtatcgcc     2580

tatgcccgcg tgccttccaa agacctgctc ttctccatcg tggaggagga actgggcaag     2640

gactgcgcca aagtcaagac cctcttcctg aagctgccag ggaagagggg cttcggctcg     2700

gcaggctgga cagtacaggc caagctggag ctctacctgt ggctgggcct cagcaagcag     2760

cgaaaggact tcctgtgtgg tctgccctgt ggcttcgagg aggtcaaggc agcccaaggc     2820

ctgggcctgc attcctttcc gcccatcagc ctagtctaca ccaagaagca agccttccag     2880

ctccgagcac acatgtatca ggcccgaagc ctctttgctg ctgacagcag tgggctctct     2940

gatccctttg cccgtgtctt cttcatcaac cagagccaat gcactgaggt tctaaacgag     3000

acactgtgtc ccacctggga ccagatgctg gtatttgaca acctggagct gtacggtgaa     3060

gctcacgagt tacgagatga tccccccatc attgtcattg aaatctacga ccaggacagc     3120

atgggcaaag ccgacttcat gggccggacc ttcgccaagc ccctggtgaa gatggcagat     3180

gaagcatact gcccacctcg cttcccgccg cagcttgagt actaccagat ctaccgaggc     3240

agtgccactg ccggagacct actggctgcc ttcgagctgc tgcagattgg gccatcaggg     3300

aaggctgacc tgccacccat caatggccca gtggacatgg acagagggcc catcatgcct     3360

gtgcccgtgg gaatccggcc agtgctcagc aagtaccgag tggaggtgct gttctggggc     3420

ctgagggacc taaagagggt gaacctggcc caggtggacc gaccacgggt ggacatcgag     3480

tgtgcaggaa agggggtaca atcctccctg attcacaatt ataagaagaa ccccaacttc     3540

aacacgctgg tcaagtggtt tgaagtggac ctcccggaga atgagctcct gcacccaccc     3600

ttgaacatcc gagtggtaga ttgccgggcc tttggacgat acaccctggt gggttcccac     3660

gcagtcagct cactgaggcg cttcatctac cgacctccag accgctcagc ccccaactgg     3720

aacaccacag gggaggttgt agtaagcatg gagcctgagg agccagttaa gaagctggag     3780

accatggtga aactggatgc gacttctgat gctgtggtca aggtggatgt ggctgaagat     3840

gagaaggaaa ggaagaagaa gaaaaagaaa ggcccgtcag aggagccaga ggaggaagag     3900

cccgatgaga gcatgctgga ttggtggtcc aagtacttcg cctccatcga cacaatgaag     3960

gagcaacttc gacaacatga gacctctgga actgacttgg aagagaagga agagatggaa     4020

agcgctgagg gcctgaaggg accaatgaag agcaaggaga agtccagagc tgcaaaggag     4080

gagaaaaaga agaaaaacca gagccctggc cctggccagg gatcggaggc tcctgagaag     4140

aagaaagcca agatcgatga gcttaaggtg taccccaagg agctggaatc ggagtttgac     4200

agctttgagg actggctgca caccttcaac ctgttgaggg gcaagacggg agatgatgag     4260

gatggctcca cagaggagga gcgcatagta ggccgattca agggctccct ctgtgtgtac     4320

aaagtgccac tcccagaaga tgtatctcga gaagctggct atgatcccac ctatggaatg     4380

ttccagggca tcccaagcaa tgaccccatc aatgtgctgg tccgaatcta tgtggtccgg     4440

gccacagacc tgcacccggc cgacatcaat ggcaaagctg acccctatat tgccatcaag     4500

ttaggcaaga ccgacatccg agacaaggag aactacatct ccaagcagct caaccctgtg     4560

tttgggaagt cctttgacat tgaggcctcc ttccccatgg agtccatgtt gacagtggcc     4620

gtgtacgact gggatctggt gggcactgat gacctcatcg gagaaaccaa gattgacctg     4680

gaaaaccgct tctacagcaa gcatcgcgcc acctgcggca tcgcacagac ctattccata     4740

catggctaca atatctggag ggaccccatg aagcccagcc agatcctgac acgcctctgt     4800

aaagagggca aagtggacgg cccccacttt ggtccccatg ggagagtgag ggttgccaac     4860

cgtgtcttca cggggccttc agaaatagag gatgagaatg gtcagaggaa gcccacagat     4920

gagcacgtgg cactgtctgc tctgagacac tgggaggaca tcccccgggt gggctgccgc     4980

cttgtgccgg aacacgtgga gaccaggccg ctgctcaacc ctgacaagcc aggcattgag     5040

cagggccgcc tggagctgtg ggtggacatg ttccccatgg acatgccagc ccctgggaca     5100

cctctggata tatcccccag gaaacccaag aagtacgagc tgcgggtcat cgtgtggaac     5160

acagacgagg tggtcctgga agacgatgat ttcttcacgg gagagaagtc cagtgacatt     5220

tttgtgaggg ggtggctgaa gggccagcag gaggacaaac aggacacaga tgtccactat     5280

cactccctca cgggggaggg caacttcaac tggagatacc tcttcccctt cgactaccta     5340

gcggccgaag agaagatcgt tatgtccaaa aaggagtcta tgttctcctg ggatgagacg     5400

gagtacaaga tccctgcgcg gctcaccctg cagatctggg acgctgacca cttctcggct     5460

gacgacttcc tgggggctat cgagctggac ctgaaccggt tcccgagggg cgctaagaca     5520

gccaagcagt gcaccatgga gatggccacc ggggaggtgg acgtacccct ggtttccatc     5580

tttaaacaga aacgtgtcaa aggctggtgg cccctcctgg cccgcaatga gaatgatgag     5640

tttgagctca caggcaaagt ggaggcggag ctacacctac tcacggcaga ggaggcagag     5700

aagaaccctg tgggcctggc tcgcaatgaa cctgatcccc tagaaaaacc caaccggcct     5760

gacacggcat tcgtctggtt cctgaaccca ctcaaatcta tcaagtacct catctgcacc     5820

cggtacaagt ggctgatcat caagatcgtg ctggcgctgc tggggctgct catgctggcc     5880

ctcttccttt acagcctccc aggctacatg gtcaagaagc tcctaggggc ctga           5934


<210>  17
<211>  1997
<212>  PRT
<213>  Mus musculus

<400>  17

Met Ala Leu Ile Val His Leu Lys Thr Val Ser Glu Leu Arg Gly Lys 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Gly Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Val Leu Glu Ile 
    50                  55                  60                  


Gln Ile Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Cys Met Val Leu Gln Lys Val Val Glu Glu Asn Arg Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Met Asp Asp Ser Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Ser Met Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Pro Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Lys Asp 
    130                 135                 140                 


Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Ser Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe Ser 
                165                 170                 175     


Ala Met Lys Leu Gly Lys Thr Arg Ser His Lys Glu Glu Pro Gln Arg 
            180                 185                 190         


Gln Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu Ala 
        195                 200                 205             


Ile Gln Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala Ser 
    210                 215                 220                 


Val Thr Ala Leu Thr Ser Asn Val Ser Asn Lys Arg Ser Lys Pro Asp 
225                 230                 235                 240 


Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val Ser 
                245                 250                 255     


Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp Pro 
            260                 265                 270         


Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met Lys 
        275                 280                 285             


Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp Phe 
    290                 295                 300                 


His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser Val 
305                 310                 315                 320 


Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser Phe 
                325                 330                 335     


Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe His 
            340                 345                 350         


His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ala Gly Leu 
        355                 360                 365             


Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp Asn 
    370                 375                 380                 


Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile Glu 
385                 390                 395                 400 


Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp Ala 
                405                 410                 415     


Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met Asn 
            420                 425                 430         


Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn Lys 
        435                 440                 445             


Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys Gly 
    450                 455                 460                 


Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu Gln 
465                 470                 475                 480 


Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys Val 
                485                 490                 495     


Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His 
            500                 505                 510         


Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe Leu 
        515                 520                 525             


Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg Asn 
    530                 535                 540                 


Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly Glu 
545                 550                 555                 560 


Gly Val Ser Phe Arg Ala Arg Leu Met Leu Gly Leu Ala Val Glu Ile 
                565                 570                 575     


Leu Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln Val 
            580                 585                 590         


Glu Gln Ala Thr Pro Val Ser Glu Ser Cys Thr Gly Arg Met Glu Glu 
        595                 600                 605             


Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg Lys 
    610                 615                 620                 


Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr Gly 
625                 630                 635                 640 


Asn Glu Val Asp Gly Met Ser Arg Pro Leu Arg Pro Arg Pro Arg Lys 
                645                 650                 655     


Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ser Ser Asp 
            660                 665                 670         


Asp Glu Gly Asp Glu Ala Gly Asp Leu Ala Ser Val Ser Ser Thr Pro 
        675                 680                 685             


Pro Met Arg Pro Gln Ile Thr Asp Arg Asn Tyr Phe His Leu Pro Tyr 
    690                 695                 700                 


Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp Gln 
705                 710                 715                 720 


Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp Lys 
                725                 730                 735     


Leu Glu Glu Gly Leu Asn Asp Val Gln Glu Met Ile Lys Thr Glu Lys 
            740                 745                 750         


Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys 
        755                 760                 765             


Gly Cys His Arg Phe Leu Ser Leu Ser Asp Lys Asp Gln Gly Arg Ser 
    770                 775                 780                 


Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu 
785                 790                 795                 800 


Leu Glu Ser Met Gly Gln Gln Ala Lys Ser Leu Arg Ala Gln Val Lys 
                805                 810                 815     


Arg His Thr Val Arg Asp Lys Leu Arg Ser Cys Gln Asn Phe Leu Gln 
            820                 825                 830         


Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Val 
        835                 840                 845             


Phe Ile Trp Met Met Ser Asn Asn Lys Arg Ile Ala Tyr Ala Arg Val 
    850                 855                 860                 


Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Leu Gly Lys 
865                 870                 875                 880 


Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg 
                885                 890                 895     


Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Leu Glu Leu Tyr 
            900                 905                 910         


Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Asp Phe Leu Cys Gly Leu 
        915                 920                 925             


Pro Cys Gly Phe Glu Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His 
    930                 935                 940                 


Ser Phe Pro Pro Ile Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln 
945                 950                 955                 960 


Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser 
                965                 970                 975     


Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln Ser 
            980                 985                 990         


Gln Cys Thr Glu Val Leu Asn Glu  Thr Leu Cys Pro Thr  Trp Asp Gln 
        995                 1000                 1005             


Met Leu  Val Phe Asp Asn Leu  Glu Leu Tyr Gly Glu  Ala His Glu 
    1010                 1015                 1020             


Leu Arg  Asp Asp Pro Pro Ile  Ile Val Ile Glu Ile  Tyr Asp Gln 
    1025                 1030                 1035             


Asp Ser  Met Gly Lys Ala Asp  Phe Met Gly Arg Thr  Phe Ala Lys 
    1040                 1045                 1050             


Pro Leu  Val Lys Met Ala Asp  Glu Ala Tyr Cys Pro  Pro Arg Phe 
    1055                 1060                 1065             


Pro Pro  Gln Leu Glu Tyr Tyr  Gln Ile Tyr Arg Gly  Ser Ala Thr 
    1070                 1075                 1080             


Ala Gly  Asp Leu Leu Ala Ala  Phe Glu Leu Leu Gln  Ile Gly Pro 
    1085                 1090                 1095             


Ser Gly  Lys Ala Asp Leu Pro  Pro Ile Asn Gly Pro  Val Asp Met 
    1100                 1105                 1110             


Asp Arg  Gly Pro Ile Met Pro  Val Pro Val Gly Ile  Arg Pro Val 
    1115                 1120                 1125             


Leu Ser  Lys Tyr Arg Val Glu  Val Leu Phe Trp Gly  Leu Arg Asp 
    1130                 1135                 1140             


Leu Lys  Arg Val Asn Leu Ala  Gln Val Asp Arg Pro  Arg Val Asp 
    1145                 1150                 1155             


Ile Glu  Cys Ala Gly Lys Gly  Val Gln Ser Ser Leu  Ile His Asn 
    1160                 1165                 1170             


Tyr Lys  Lys Asn Pro Asn Phe  Asn Thr Leu Val Lys  Trp Phe Glu 
    1175                 1180                 1185             


Val Asp  Leu Pro Glu Asn Glu  Leu Leu His Pro Pro  Leu Asn Ile 
    1190                 1195                 1200             


Arg Val  Val Asp Cys Arg Ala  Phe Gly Arg Tyr Thr  Leu Val Gly 
    1205                 1210                 1215             


Ser His  Ala Val Ser Ser Leu  Arg Arg Phe Ile Tyr  Arg Pro Pro 
    1220                 1225                 1230             


Asp Arg  Ser Ala Pro Asn Trp  Asn Thr Thr Val Arg  Leu Leu Arg 
    1235                 1240                 1245             


Gly Cys  His Arg Leu Arg Asn  Gly Gly Pro Ser Ser  Arg Pro Thr 
    1250                 1255                 1260             


Gly Glu  Val Val Val Ser Met  Glu Pro Glu Glu Pro  Val Lys Lys 
    1265                 1270                 1275             


Leu Glu  Thr Met Val Lys Leu  Asp Ala Thr Ser Asp  Ala Val Val 
    1280                 1285                 1290             


Lys Val  Asp Val Ala Glu Asp  Glu Lys Glu Arg Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Pro Ser Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  His Glu Thr Ser Gly  Thr Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Met Glu  Ser Ala Glu Gly Leu  Lys Gly Pro 
    1355                 1360                 1365             


Met Lys  Ser Lys Glu Lys Ser  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Asn Gln Ser Pro Gly  Pro Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Ala Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Ser Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Pro Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Ile Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Lys  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Ile  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Glu Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro His Gly Arg  Val Arg Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Ser Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Val Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Val Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Met Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys 
    1955                 1960                 1965             


Phe Leu  Leu Leu Phe Leu Leu  Leu Leu Leu Phe Ala  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Leu Pro Gly Tyr Leu  Ala Lys Lys Ile Leu  Gly Ala 
    1985                 1990                 1995         


<210>  18
<211>  5994
<212>  DNA
<213>  Mus musculus

<400>  18
atggccctga ttgttcacct caagactgtc tcagagctcc gaggcaaagg tgaccggatt       60

gccaaagtca ctttccgagg gcagtctttc tactcccggg tcctggagaa ctgcgagggt      120

gtggctgact ttgatgagac gttccggtgg ccagtggcca gcagcatcga ccggaatgaa      180

gtgttggaga ttcagatttt caactacagc aaagtcttca gcaacaagct gatagggacc      240

ttctgcatgg tgctgcagaa agtggtggag gagaatcggg tagaggtgac cgacacgctg      300

atggatgaca gcaatgctat catcaagacc agcctgagca tggaggtccg gtatcaggcc      360

acagatggca ctgtgggccc ctgggatgat ggagacttcc tgggagatga atccctccag      420

gaggagaagg acagccagga gacagatggg ctgctacctg gttcccgacc cagcacccgg      480

atatctggcg agaagagctt tcgcagagcg ggaaggagtg tgttctcggc catgaaactc      540

ggcaaaactc ggtcccacaa agaggagccc caaagacaag atgagccagc agtgctggag      600

atggaggacc tggaccacct agccattcag ctgggggatg ggctggatcc tgactccgtg      660

tctctagcct cggtcaccgc tctcaccagc aatgtctcca acaaacggtc taagccagat      720

attaagatgg agcccagtgc tggaaggccc atggattacc aggtcagcat cacagtgatt      780

gaggctcggc agctggtggg cttgaacatg gaccctgtgg tgtgtgtgga ggtgggtgat      840

gacaagaaat acacgtcaat gaaggagtcc acaaactgcc cttactacaa cgagtacttt      900

gtcttcgact tccatgtctc tcctgatgtc atgtttgaca agatcatcaa gatctcggtt      960

atccattcta agaacctgct tcggagcggc accctggtgg gttccttcaa aatggatgtg     1020

gggactgtgt attcccagcc tgaacaccag ttccatcaca aatgggccat cctgtcagac     1080

cccgatgaca tctctgctgg gttgaagggt tatgtaaagt gtgatgtcgc tgtggtgggc     1140

aagggagaca acatcaagac accccacaag gccaacgaga cggatgagga cgacattgaa     1200

gggaacttgc tgctccccga gggcgtgccc cccgaacggc agtgggcacg gttctatgtg     1260

aaaatttacc gagcagaggg actgccccgg atgaacacaa gcctcatggc caacgtgaag     1320

aaggcgttca tcggtgagaa caaggacctc gtcgacccct atgtgcaagt cttctttgct     1380

ggacaaaagg gcaaaacatc agtgcagaag agcagctatg agccgctatg gaatgagcag     1440

gtcgtcttca cagacttgtt ccccccactc tgcaaacgca tgaaggtgca gatccgggac     1500

tctgacaagg tcaatgatgt ggccatcggc acccacttca tcgacctgcg caagatttcc     1560

aacgatggag acaaaggctt cctgcctacc ctcggtccag cctgggtgaa catgtacggc     1620

tccacgcgca actacacact gctggacgag caccaggact tgaatgaagg cctgggggag     1680

ggtgtgtcct tccgggcccg cctcatgttg ggactagctg tggagatcct ggacacctcc     1740

aacccagagc tcaccagctc cacggaggtg caggtggagc aggccacgcc tgtctcggag     1800

agctgcacag ggagaatgga agaatttttt ctatttggag ccttcttgga agcctcaatg     1860

attgaccgga aaaatgggga caagccaatt acctttgagg tgaccatagg aaactacggc     1920

aatgaagtcg atggtatgtc ccggcccctg aggcctcggc cccggaaaga gcctggggat     1980

gaagaagagg tagacctgat tcagaactcc agtgacgatg aaggtgacga agccggggac     2040

ctggcctcgg tgtcctccac cccacctatg cggccccaga tcacggacag gaactatttc     2100

cacctgccct acctggagcg caagccctgc atctatatca agagctggtg gcctgaccag     2160

aggcggcgcc tctacaatgc caacatcatg gatcacattg ctgacaagct ggaagaaggc     2220

ctgaatgatg tacaggagat gatcaaaacg gagaagtcct acccggagcg ccgcctgcgg     2280

ggtgtgctag aggaactcag ctgtggctgc caccgcttcc tctccctctc ggacaaggac     2340

cagggccgct cgtcccgcac caggctggat cgagagcgtc ttaagtcctg tatgagggag     2400

ttggagagca tgggacagca ggccaagagc ctgagggctc aggtgaagcg gcacactgtt     2460

cgggacaagc tgaggtcatg ccagaacttt ctgcagaagc tacgcttcct ggcggatgag     2520

ccccagcaca gcattcctga tgtgttcatt tggatgatga gcaacaacaa acgtatcgcc     2580

tatgcccgcg tgccttccaa agacctgctc ttctccatcg tggaggagga actgggcaag     2640

gactgcgcca aagtcaagac cctcttcctg aagctgccag ggaagagggg cttcggctcg     2700

gcaggctgga cagtacaggc caagctggag ctctacctgt ggctgggcct cagcaagcag     2760

cgaaaggact tcctgtgtgg tctgccctgt ggcttcgagg aggtcaaggc agcccaaggc     2820

ctgggcctgc attcctttcc gcccatcagc ctagtctaca ccaagaagca agccttccag     2880

ctccgagcac acatgtatca ggcccgaagc ctctttgctg ctgacagcag tgggctctct     2940

gatccctttg cccgtgtctt cttcatcaac cagagccaat gcactgaggt tctaaacgag     3000

acactgtgtc ccacctggga ccagatgctg gtatttgaca acctggagct gtacggtgaa     3060

gctcacgagt tacgagatga tccccccatc attgtcattg aaatctacga ccaggacagc     3120

atgggcaaag ccgacttcat gggccggacc ttcgccaagc ccctggtgaa gatggcagat     3180

gaagcatact gcccacctcg cttcccgccg cagcttgagt actaccagat ctaccgaggc     3240

agtgccactg ccggagacct actggctgcc ttcgagctgc tgcagattgg gccatcaggg     3300

aaggctgacc tgccacccat caatggccca gtggacatgg acagagggcc catcatgcct     3360

gtgcccgtgg gaatccggcc agtgctcagc aagtaccgag tggaggtgct gttctggggc     3420

ctgagggacc taaagagggt gaacctggcc caggtggacc gaccacgggt ggacatcgag     3480

tgtgcaggaa agggggtaca atcctccctg attcacaatt ataagaagaa ccccaacttc     3540

aacacgctgg tcaagtggtt tgaagtggac ctcccggaga atgagctcct gcacccaccc     3600

ttgaacatcc gagtggtaga ttgccgggcc tttggacgat acaccctggt gggttcccac     3660

gcagtcagct cactgaggcg cttcatctac cgacctccag accgctcagc ccccaactgg     3720

aacaccacag tcaggctgct ccggggctgc cacaggctgc gcaatggggg cccctcttct     3780

cgccccacag gggaggttgt agtaagcatg gagcctgagg agccagttaa gaagctggag     3840

accatggtga aactggatgc gacttctgat gctgtggtca aggtggatgt ggctgaagat     3900

gagaaggaaa ggaagaagaa gaaaaagaaa ggcccgtcag aggagccaga ggaggaagag     3960

cccgatgaga gcatgctgga ttggtggtcc aagtacttcg cctccatcga cacaatgaag     4020

gagcaacttc gacaacatga gacctctgga actgacttgg aagagaagga agagatggaa     4080

agcgctgagg gcctgaaggg accaatgaag agcaaggaga agtccagagc tgcaaaggag     4140

gagaaaaaga agaaaaacca gagccctggc cctggccagg gatcggaggc tcctgagaag     4200

aagaaagcca agatcgatga gcttaaggtg taccccaagg agctggaatc ggagtttgac     4260

agctttgagg actggctgca caccttcaac ctgttgaggg gcaagacggg agatgatgag     4320

gatggctcca cagaggagga gcgcatagta ggccgattca agggctccct ctgtgtgtac     4380

aaagtgccac tcccagaaga tgtatctcga gaagctggct atgatcccac ctatggaatg     4440

ttccagggca tcccaagcaa tgaccccatc aatgtgctgg tccgaatcta tgtggtccgg     4500

gccacagacc tgcacccggc cgacatcaat ggcaaagctg acccctatat tgccatcaag     4560

ttaggcaaga ccgacatccg agacaaggag aactacatct ccaagcagct caaccctgtg     4620

tttgggaagt cctttgacat tgaggcctcc ttccccatgg agtccatgtt gacagtggcc     4680

gtgtacgact gggatctggt gggcactgat gacctcatcg gagaaaccaa gattgacctg     4740

gaaaaccgct tctacagcaa gcatcgcgcc acctgcggca tcgcacagac ctattccata     4800

catggctaca atatctggag ggaccccatg aagcccagcc agatcctgac acgcctctgt     4860

aaagagggca aagtggacgg cccccacttt ggtccccatg ggagagtgag ggttgccaac     4920

cgtgtcttca cggggccttc agaaatagag gatgagaatg gtcagaggaa gcccacagat     4980

gagcacgtgg cactgtctgc tctgagacac tgggaggaca tcccccgggt gggctgccgc     5040

cttgtgccgg aacacgtgga gaccaggccg ctgctcaacc ctgacaagcc aggcattgag     5100

cagggccgcc tggagctgtg ggtggacatg ttccccatgg acatgccagc ccctgggaca     5160

cctctggata tatcccccag gaaacccaag aagtacgagc tgcgggtcat cgtgtggaac     5220

acagacgagg tggtcctgga agacgatgat ttcttcacgg gagagaagtc cagtgacatt     5280

tttgtgaggg ggtggctgaa gggccagcag gaggacaaac aggacacaga tgtccactat     5340

cactccctca cgggggaggg caacttcaac tggagatacc tcttcccctt cgactaccta     5400

gcggccgaag agaagatcgt tatgtccaaa aaggagtcta tgttctcctg ggatgagacg     5460

gagtacaaga tccctgcgcg gctcaccctg cagatctggg acgctgacca cttctcggct     5520

gacgacttcc tgggggctat cgagctggac ctgaaccggt tcccgagggg cgctaagaca     5580

gccaagcagt gcaccatgga gatggccacc ggggaggtgg acgtacccct ggtttccatc     5640

tttaaacaga aacgtgtcaa aggctggtgg cccctcctgg cccgcaatga gaatgatgag     5700

tttgagctca caggcaaagt ggaggcggag ctacacctac tcacggcaga ggaggcagag     5760

aagaaccctg tgggcctggc tcgcaatgaa cctgatcccc tagaaaaacc caatcggccg     5820

gacacaagct tcatctggtt cttgaaccct ctcaagtctg cccgctactt cctgtggcat     5880

acctaccgct ggctactcct caaattcctg ctgctcttcc tcctgctgct gctcttcgcc     5940

ctgtttctct actctctgcc tggctacctg gccaagaaga tccttggggc ctga           5994


<210>  19
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer A_F2

<400>  19
aattcaagct gctagcatgg ccctgattgt tcacc                                  35


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer A_R1

<400>  20
cgtttgttgt tgctcatcat ccaaatg                                           27


<210>  21
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer B_F1

<400>  21
gagcaacaac aaacgtatcg cctatgc                                           27


<210>  22
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer B_R1

<400>  22
gcagctcgta cttcttgggt ttcctg                                            26


<210>  23
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer C_F1

<400>  23
agaagtacga gctgcgggtc atcgtg                                            26


<210>  24
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer C_R2

<400>  24
gattatcgat aagcttttag gcccctagga gctt                                   34


