                         SEQUENCE LISTING

<110>  The Government of the United States of America
 
<120>  TREATMENT OF INFECTIONS AND IMMUNE DYSREGULATION IN PATIENTS WITH
        PRIMARY IMMUNE DEFICIENCIES USING MRNA-CORRECTED AUTOLOGOUS 
       GRANULOCYTES, LYMPHOCYTES AND/OR NATURAL KILLER CELLS

<130>  4239-100131-02

<150>  62/710,339
<151>  2018-02-16

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  1792
<212>  DNA
<213>  Homo sapiens

<400>  1
aattctgcag tcgacggtac cgcgggcccg ggatccaccg gtccgggatc caccggtcct       60

tgcgggccac catgggcaac tgggcggtga acgagggcct gagcattttc gtgatcctcg      120

tgtggctggg cctgaatgtc tttctgttcg tgtggtacta ccgcgtgtat gacatcccac      180

cgaagttttt ctatacccgg aagctgctgg gctccgctct cgccctggct agggccccgg      240

ccgcctgcct gaatttcaat tgcatgctca tcctgctgcc cgtgtgtcgg aacctgctga      300

gcttcctgcg cgggtccagc gcctgctgca gcaccagggt gcgccgccag ctggaccgca      360

acctcacgtt ccacaagatg gtggcctgga tgatcgccct gcatagcgcc atccacacga      420

tcgcccacct gttcaacgtg gagtggtgcg tcaacgccag ggtgaataac agcgacccat      480

acagcgtcgc cctctccgag ctgggggacc gccagaacga gagctacctg aattttgccc      540

gcaagcggat taagaaccct gaaggcgggc tgtacctcgc cgtgaccctg ctggcgggca      600

tcaccggcgt ggtgattacc ctgtgcctca tcctgatcat caccagcagc accaagacca      660

tccgccgctc ctacttcgag gtgttctggt acacccacca cctgttcgtg attttcttca      720

tcggcctcgc cattcacggc gccgagcgca tcgtgcgggg ccagaccgcc gaatccctcg      780

cggtgcacaa catcacggtg tgcgagcaga aaatctccga gtggggcaaa atcaaggaat      840

gcccgatccc ccagttcgcg gggaatcccc ctatgacctg gaagtggatt gtgggcccta      900

tgttcctgta tctctgcgag cggctcgtca ggttttggcg cagccagcag aaggtggtca      960

ttaccaaagt cgtgacccac ccatttaaga ccatcgagct gcagatgaag aagaagggct     1020

tcaagatgga ggtgggccag tacatcttcg tgaagtgtcc gaaggtctcc aagctggagt     1080

ggcacccctt caccctcacc tccgctcctg aagaggattt cttctccatc cacatccgga     1140

tcgtgggcga ctggaccgag ggcctcttta acgcctgcgg gtgcgacaag caggagttcc     1200

aggacgcctg gaagctgccc aagatcgccg tggacggccc cttcggcacc gccagcgagg     1260

acgtctttag ctatgaggtg gtcatgctgg tgggcgccgg catcggggtg acccccttcg     1320

ccagcatcct gaagagcgtg tggtataagt actgtaacaa cgctaccaac ctgaagctga     1380

aaaagattta cttctactgg ctgtgtaggg acacccacgc gttcgagtgg tttgccgacc     1440

tgctgcagct gctggagagc cagatgcagg agcgcaacaa tgccggcttc ctgtcctaca     1500

acatctacct gaccgggtgg gacgagagcc aggcgaacca tttcgcggtg caccacgacg     1560

aggagaagga tgtcatcacc ggcctcaaac agaagaccct ctacggcagg cccaactggg     1620

ataacgagtt caagacgatc gctagccagc atcccaacac gaggatcggg gtcttcctct     1680

gtgggcccga ggctctcgct gaaacgctct ccaagcagtc catctccaac tccgaatccg     1740

ggccccgcgg ggtccatttc atcttcaaca aagaaaactt ctgaggatcc ga             1792


<210>  2
<211>  4035
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (63)..(1166)

<400>  2
gtgtagcgcc agcgcgctgt gacgtaatgt gaggggtctc ccggcagggc tgagctggac       60

ca atg agg aaa ggc aag ggg ccg att tgc ctg ttc tca cgc ccc acc         107
   Met Arg Lys Gly Lys Gly Pro Ile Cys Leu Phe Ser Arg Pro Thr            
   1               5                   10                  15             

ctc aga cct agc cgg agc aaa gtt tca ctt ata gaa ggg aga gga gcg        155
Leu Arg Pro Ser Arg Ser Lys Val Ser Leu Ile Glu Gly Arg Gly Ala           
                20                  25                  30                

aac atg gca gcg cgt tgg cgg ttt tgg tgt gtc tct gtg acc atg gtg        203
Asn Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val           
            35                  40                  45                    

gtg gcg ctg ctc atc gtt tgc gac gtt ccc tca gcc tct gcc caa aga        251
Val Ala Leu Leu Ile Val Cys Asp Val Pro Ser Ala Ser Ala Gln Arg           
        50                  55                  60                        

aag aag gag atg gtg tta tct gaa aag gtt agt cag ctg atg gaa tgg        299
Lys Lys Glu Met Val Leu Ser Glu Lys Val Ser Gln Leu Met Glu Trp           
    65                  70                  75                            

act aac aaa aga cct gta ata aga atg aat gga gac aag ttc cgt cgc        347
Thr Asn Lys Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Arg           
80                  85                  90                  95            

ctt gtg aaa gcc cca ccg aga aat tac tcc gtt atc gtc atg ttc act        395
Leu Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr           
                100                 105                 110               

gct ctc caa ctg cat aga cag tgt gtc gtt tgc aag caa gct gat gaa        443
Ala Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu           
            115                 120                 125                   

gaa ttc cag atc ctg gca aac tcc tgg cga tac tcc agt gca ttc acc        491
Glu Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr           
        130                 135                 140                       

aac agg ata ttt ttt gcc atg gtg gat ttt gat gaa ggc tct gat gta        539
Asn Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val           
    145                 150                 155                           

ttt cag atg cta aac atg aat tca gct cca act ttc atc aac ttt cct        587
Phe Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro           
160                 165                 170                 175           

gca aaa ggg aaa ccc aaa cgg ggt gat aca tat gag tta cag gtg cgg        635
Ala Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr Glu Leu Gln Val Arg           
                180                 185                 190               

ggt ttt tca gct gag cag att gcc cgg tgg atc gcc gac aga act gat        683
Gly Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp           
            195                 200                 205                   

gtc aat att aga gtg att aga ccc cca aat tat gct ggt ccc ctt atg        731
Val Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met           
        210                 215                 220                       

ttg gga ttg ctt ttg gct gtt att ggt gga ctt gtg tat ctt cga aga        779
Leu Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg           
    225                 230                 235                           

agt aat atg gaa ttt ctc ttt aat aaa act gga tgg gct ttt gca gct        827
Ser Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala           
240                 245                 250                 255           

ttg tgt ttt gtg ctt gct atg aca tct ggt caa atg tgg aac cat ata        875
Leu Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile           
                260                 265                 270               

aga gga cca cca tat gcc cat aag aat ccc cac acg gga cat gtg aat        923
Arg Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn           
            275                 280                 285                   

tat atc cat gga agc agt caa gcc cag ttt gta gct gaa aca cac att        971
Tyr Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile           
        290                 295                 300                       

gtt ctt ctg ttt aat ggt gga gtt acc tta gga atg gtg ctt tta tgt       1019
Val Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys           
    305                 310                 315                           

gaa gct gct acc tct gac atg gat att gga aag cga aag ata atg tgt       1067
Glu Ala Ala Thr Ser Asp Met Asp Ile Gly Lys Arg Lys Ile Met Cys           
320                 325                 330                 335           

gtg gct ggt att gga ctt gtt gta tta ttc ttc agt tgg atg ctc tct       1115
Val Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser           
                340                 345                 350               

att ttt aga tct aaa tat cat ggc tac cca tac agc ttt ctg atg agt       1163
Ile Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser           
            355                 360                 365                   

taa aaaggtccca gagatatata gacactggag tactggaaat tgaaaaacga            1216

aaatcgtgtg tgtttgaaaa gaagaatgca acttgtatat tttgtattac ctcttttttt     1276

caagtgattt aaatagttaa tcatttaacc aaagaagatg tgtagtgcct taacaagcaa     1336

tcctctgtca aaatctgagg tatttgaaaa taattatcct cttaaccttc tcttcccagt     1396

gaactttatg gaacatttaa tttagtacaa ttaagtatat tataaaaatt gtaaaactac     1456

tactttgttt tagttagaac aaagctcaaa actactttag ttaacttggt catctgattt     1516

tatattgcct tatccaaaga tggggaaagt aagtcctgac caggtgttcc cacatatgcc     1576

tgttacagat aactacatta ggaattcatt cttagcttct tcatctttgt gtggatgtgt     1636

atactttacg catctttcct tttgagtaga gaaattatgt gtgtcatgtg gtcttctgaa     1696

aatggaacac cattcttcag agcacacgtc tagccctcag caagacagtt gtttctcctc     1756

ctccttgcat atttcctact gaaatacagt gctgtctatg attgtttttg ttttgttgtt     1816

tttttgagac ggtctcgctg tgtcacacag gctggagtgc agtggcgtga gctcggctga     1876

ctgcaaactc tgcctcccag gtttaagcga ttctcctgtc acagcttccc aagtagctgg     1936

gatttacagg tgtgcaccgc catgccaggc taatttttgt gtttttagta gagacagggt     1996

ttcgccaagt tgtccaggct ggtcttgaac tcctgggctc aagtgatccg cccgcctcag     2056

tctcccaaag tgcgaggatg acatgtgtga gctaccacac cagcaatgtc tatgcttctc     2116

gatagctgtg aacatgaaaa gacatctatt gggagtccga ggcaggtgga ttgcttgagg     2176

ccaggagtta gagaccagcc tggccaacaa ggcaaaaccc cgtctctact aaaaatatga     2236

aaattagctg ggcttggtgg ctcatgccta taatcctagc tacttgggag gctgaggcac     2296

gagacttgct taatacctgg gaggcggaga ttgcagtgag ccgagatcac gctactgcgc     2356

tccagcctga gtgatagagt gagactctgt ctcaaaaaaa agtatctcta aatacaggat     2416

tataatttct gcttgagtat ggtgttaact accttgtatt tagaaagatt tcagattcat     2476

tccatctcct tagttttctt ttaaggtgac ccatctgtga taaaaatata gcttagtgct     2536

aaaatcagtg taacttatac atggcctaaa atgtttctac aaattagagt ttgtcactta     2596

ttccatttgt acctaagaga aaaataggct cagttagaaa aggactccct ggccaggcgc     2656

agtgacttac gcctgtaatc tcagcacttt gggaggccaa ggcaggcaga tcacgaggtc     2716

aggagttcga gaccatcctg gccaacatgg tgaaaccccg tctctactaa aaatataaaa     2776

attagctggg tgtggtggca ggagcctgta atcccagcta cacaggaggc tgaggcacga     2836

gaatcacttg aactcaggag atggaggttt cagtgagcca agatcacacc actgcactcc     2896

agcctggcaa cagagcgaga ctccatctca aaaaaaaaaa aaaaagtaag aaagaaaagg     2956

actcccttag aatgggaaag aaaaatcata aaatattgag ctgatgcctg tatatagaaa     3016

ttaagcgttt ctcgaaagct gttctatgtt ttgctgttat tttagtcttt attctcttcc     3076

tttaggtgga gaaacaaagt accaatttga agggattttt tttattttgt cttttggttt     3136

ctgtcagtag aaataaccat atgtgctaac caaatttctg tgaagaatgt tttcatggtt     3196

atcattatat ctaactataa cctcccccat agttatgaag agtaacctga aatgccacta     3256

ttgtggaaat aggataattg taattgtgaa aaaataattt taaggaaatc ttacaagtat     3316

tacattaaaa agatactatg actgccacct gccatttacc ttctaataac cctgccatgt     3376

ggtttgcaga aagagatgga tatagtagcc tcagaagaaa tattttatgt gggttttttg     3436

tttttcgtta ctagatttca tggatgaggg gatatggttg accttttact ttttaatgga     3496

gcagccagtt tttgttaatt actcacttgt aaattgtgag attctgaatt ccttacctgc     3556

tattcttgta cttgtctcag gccaaatcta tgctgtggtt cttatgagac ttgtatgaag     3616

atgccctgat ttgtacagat tgaccacggg aatactactg ccatgtaatc tgtatagttc     3676

cagataattt gtcatgaaca ttgacagaat gacaattttt tgtatttgct ttttctccct     3736

ttaagagcac attcttctgt aaggagaaag gcagcattct ggctaaaatg tgtagaaggt     3796

aatttactac acttataaaa tagtgtgact tttgtgaaaa ttttgaatta gctttcatat     3856

gaagtgcctt aagtagactc ttcatttact tttctggtaa tggtttaaat atcatttgtt     3916

atgcattttt aagatacagt tcagaatgac acattgtagt ggcaaagata accaaatgtc     3976

tggctgtttg ctttttgacc atatcaataa acttttacaa tctaaaaaaa aaaaaaaaa      4035


<210>  3
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Lys Gly Lys Gly Pro Ile Cys Leu Phe Ser Arg Pro Thr Leu 
1               5                   10                  15      


Arg Pro Ser Arg Ser Lys Val Ser Leu Ile Glu Gly Arg Gly Ala Asn 
            20                  25                  30          


Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val Val 
        35                  40                  45              


Ala Leu Leu Ile Val Cys Asp Val Pro Ser Ala Ser Ala Gln Arg Lys 
    50                  55                  60                  


Lys Glu Met Val Leu Ser Glu Lys Val Ser Gln Leu Met Glu Trp Thr 
65                  70                  75                  80  


Asn Lys Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Arg Leu 
                85                  90                  95      


Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 
            100                 105                 110         


Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 
        115                 120                 125             


Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr Asn 
    130                 135                 140                 


Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 
145                 150                 155                 160 


Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro Ala 
                165                 170                 175     


Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr Glu Leu Gln Val Arg Gly 
            180                 185                 190         


Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp Val 
        195                 200                 205             


Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu 
    210                 215                 220                 


Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg Ser 
225                 230                 235                 240 


Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu 
                245                 250                 255     


Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg 
            260                 265                 270         


Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr 
        275                 280                 285             


Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile Val 
    290                 295                 300                 


Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 
305                 310                 315                 320 


Ala Ala Thr Ser Asp Met Asp Ile Gly Lys Arg Lys Ile Met Cys Val 
                325                 330                 335     


Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser Ile 
            340                 345                 350         


Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 
        355                 360                 365         


<210>  4
<211>  4353
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (62)..(1774)

<400>  4
attggaagaa gaagcatagt atagaagaaa ggcaaacaca acacattcaa cctctgccac       60

c atg ggg aac tgg gct gtg aat gag ggg ctc tcc att ttt gtc att ctg      109
  Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu         
  1               5                   10                  15              

gtt tgg ctg ggg ttg aac gtc ttc ctc ttt gtc tgg tat tac cgg gtt        157
Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Trp Tyr Tyr Arg Val           
            20                  25                  30                    

tat gat att cca cct aag ttc ttt tac aca aga aaa ctt ctt ggg tca        205
Tyr Asp Ile Pro Pro Lys Phe Phe Tyr Thr Arg Lys Leu Leu Gly Ser           
        35                  40                  45                        

gca ctg gca ctg gcc agg gcc cct gca gcc tgc ctg aat ttc aac tgc        253
Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys           
    50                  55                  60                            

atg ctg att ctc ttg cca gtc tgt cga aat ctg ctg tcc ttc ctc agg        301
Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg           
65                  70                  75                  80            

ggt tcc agt gcg tgc tgc tca aca aga gtt cga aga caa ctg gac agg        349
Gly Ser Ser Ala Cys Cys Ser Thr Arg Val Arg Arg Gln Leu Asp Arg           
                85                  90                  95                

aat ctc acc ttt cat aaa atg gtg gca tgg atg att gca ctt cac tct        397
Asn Leu Thr Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Ser           
            100                 105                 110                   

gcg att cac acc att gca cat cta ttt aat gtg gaa tgg tgt gtg aat        445
Ala Ile His Thr Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn           
        115                 120                 125                       

gcc cga gtc aat aat tct gat cct tat tca gta gca ctc tct gaa ctt        493
Ala Arg Val Asn Asn Ser Asp Pro Tyr Ser Val Ala Leu Ser Glu Leu           
    130                 135                 140                           

gga gac agg caa aat gaa agt tat ctc aat ttt gct cga aag aga ata        541
Gly Asp Arg Gln Asn Glu Ser Tyr Leu Asn Phe Ala Arg Lys Arg Ile           
145                 150                 155                 160           

aag aac cct gaa gga ggc ctg tac ctg gct gtg acc ctg ttg gca ggc        589
Lys Asn Pro Glu Gly Gly Leu Tyr Leu Ala Val Thr Leu Leu Ala Gly           
                165                 170                 175               

atc act gga gtt gtc atc acg ctg tgc ctc ata tta att atc act tcc        637
Ile Thr Gly Val Val Ile Thr Leu Cys Leu Ile Leu Ile Ile Thr Ser           
            180                 185                 190                   

tcc acc aaa acc atc cgg agg tct tac ttt gaa gtc ttt tgg tac aca        685
Ser Thr Lys Thr Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr           
        195                 200                 205                       

cat cat ctc ttt gtg atc ttc ttc att ggc ctt gcc atc cat gga gct        733
His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala           
    210                 215                 220                           

gaa cga att gta cgt ggg cag acc gca gag agt ttg gct gtg cat aat        781
Glu Arg Ile Val Arg Gly Gln Thr Ala Glu Ser Leu Ala Val His Asn           
225                 230                 235                 240           

ata aca gtt tgt gaa caa aaa atc tca gaa tgg gga aaa ata aag gaa        829
Ile Thr Val Cys Glu Gln Lys Ile Ser Glu Trp Gly Lys Ile Lys Glu           
                245                 250                 255               

tgc cca atc cct cag ttt gct gga aac cct cct atg act tgg aaa tgg        877
Cys Pro Ile Pro Gln Phe Ala Gly Asn Pro Pro Met Thr Trp Lys Trp           
            260                 265                 270                   

ata gtg ggt ccc atg ttt ctg tat ctc tgt gag agg ttg gtg cgg ttt        925
Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe           
        275                 280                 285                       

tgg cga tct caa cag aag gtg gtc atc acc aag gtg gtc act cac cct        973
Trp Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Thr His Pro           
    290                 295                 300                           

ttc aaa acc atc gag cta cag atg aag aag aag ggg ttc aaa atg gaa       1021
Phe Lys Thr Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu           
305                 310                 315                 320           

gtg gga caa tac att ttt gtc aag tgc cca aag gtg tcc aag ctg gag       1069
Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu           
                325                 330                 335               

tgg cac cct ttt aca ctg aca tcc gcc cct gag gaa gac ttc ttt agt       1117
Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser           
            340                 345                 350                   

atc cat atc cgc atc gtt ggg gac tgg aca gag ggg ctg ttc aat gct       1165
Ile His Ile Arg Ile Val Gly Asp Trp Thr Glu Gly Leu Phe Asn Ala           
        355                 360                 365                       

tgt ggc tgt gat aag cag gag ttt caa gat gcg tgg aaa cta cct aag       1213
Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys           
    370                 375                 380                           

ata gcg gtt gat ggg ccc ttt ggc act gcc agt gaa gat gtg ttc agc       1261
Ile Ala Val Asp Gly Pro Phe Gly Thr Ala Ser Glu Asp Val Phe Ser           
385                 390                 395                 400           

tat gag gtg gtg atg tta gtg gga gca ggg att ggg gtc aca ccc ttc       1309
Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Thr Pro Phe           
                405                 410                 415               

gca tcc att ctc aag tca gtc tgg tac aaa tat tgc aat aac gcc acc       1357
Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asn Asn Ala Thr           
            420                 425                 430                   

aat ctg aag ctc aaa aag atc tac ttc tac tgg ctg tgc cgg gac aca       1405
Asn Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Thr           
        435                 440                 445                       

cat gcc ttt gag tgg ttt gca gat ctg ctg caa ctg ctg gag agc cag       1453
His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Ser Gln           
    450                 455                 460                           

atg cag gaa agg aac aat gcc ggc ttc ctc agc tac aac atc tac ctc       1501
Met Gln Glu Arg Asn Asn Ala Gly Phe Leu Ser Tyr Asn Ile Tyr Leu           
465                 470                 475                 480           

act ggc tgg gat gag tct cag gcc aat cac ttt gct gtg cac cat gat       1549
Thr Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp           
                485                 490                 495               

gag gag aaa gat gtg atc aca ggc ctg aaa caa aag act ttg tat gga       1597
Glu Glu Lys Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Leu Tyr Gly           
            500                 505                 510                   

cgg ccc aac tgg gat aat gaa ttc aag aca att gca agt caa cac cct       1645
Arg Pro Asn Trp Asp Asn Glu Phe Lys Thr Ile Ala Ser Gln His Pro           
        515                 520                 525                       

aat acc aga ata gga gtt ttc ctc tgt gga cct gaa gcc ttg gct gaa       1693
Asn Thr Arg Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu           
    530                 535                 540                           

acc ctg agt aaa caa agc atc tcc aac tct gag tct ggc cct cgg gga       1741
Thr Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly           
545                 550                 555                 560           

gtg cat ttc att ttc aac aag gaa aac ttc taa cttgtctctt ccatgaggaa     1794
Val His Phe Ile Phe Asn Lys Glu Asn Phe                                   
                565                 570                                   

ataaatgtgg gttgtgctgc caaatgctca aataatgcta attgataata taaatacccc     1854

ctgcttaaaa atggacaaaa agaaactata atgtaatggt tttcccttaa aggaatgtca     1914

aagattgttt gatagtgata agttacattt atgtggagct ctatggtttt gagagcactt     1974

ttacaaacat tatttcattt ttttcctctc agtaatgtca gtggaagtta gggaaaagat     2034

tcttggactc aattttagaa tcaaaaggga aaggatcaaa aggttcagta acttccctaa     2094

gattatgaaa ctgtgaccag atctagccca tcttactcca ggtttgatac tctttccaca     2154

atactgagct gcctcagaat cctcaaaatc agtttttata ttccccaaaa gaagaaggaa     2214

accaaggagt agctatatat ttctactttg tgtcattttt gccatcatta ttatcatact     2274

gaaggaaatt ttccagatca ttaggacata atacatgttg agagtgtctc aacacttatt     2334

agtgacagta ttgacatctg agcatactcc agtttactaa tacagcaggg taactgggcc     2394

agatgttctt tctacagaag aatattggat tgattggagt taatgtaata ctcatcattt     2454

accactgtgc ttggcagaga gcggatactc aagtaagttt tgttaaatga atgaatgaat     2514

ttagaaccac acaatgccaa gatagaatta atttaaagcc ttaaacaaaa tttatctaaa     2574

gaaataactt ctattactgt catagaccaa aggaatctga ttctccctag ggtcaagaac     2634

aggctaagga tactaaccaa taggattgcc tgaagggttc tgcacattct tatttgaagc     2694

atgaaaaaag agggttggag gtggagaatt aacctcctgc catgactctg gctcatctag     2754

tcctgctcct tgtgctataa aataaatgca gactaatttc ctgcccaaag tggtcttctc     2814

cagctagccc ttatgaatat tgaacttagg aattgtgaca aatatgtatc tgatatggtc     2874

atttgtttta aataacaccc accccttatt ttccgtaaat acacacacaa aatggatcgc     2934

atctgtgtga ctaatggttt atttgtatta tatcatcatc atcatcctaa aattaacaac     2994

ccagaaacaa aaatctctat acagagatca aattcacact caatagtatg ttctgaatat     3054

atgttcaaga gagagtctct aaatcactgt tagtgtggcc aagagcaggg ttttcttttt     3114

gttcttagaa ctgctcccat ttctgggaac taaaaccagt tttatttgcc ccaccccttg     3174

gagccacaaa tgtttagaac tcttcaactt cggtaatgag gaagaaggag aaagagctgg     3234

gggaagggca gaagactggt ttaggaggaa aaggaaataa ggagaaaaga gaatgggaga     3294

gtgagagaaa ataaaaaagg caaaagggag agagagggga agggggtctc atattggtca     3354

ttccctgccc cagatttctt aaagtttgat atgtatagaa tataattgaa ggaggtatac     3414

acatattgat gttgttttga ttatctatgg tattgaatct tttaaaatct ggtcacaaat     3474

tttgatgctg agggggatta ttcaagggac taggatgaac taaataagaa ctcagttgtt     3534

ctttgtcata ctactattcc tttcgtctcc cagaatcctc agggcactga gggtaggtct     3594

gacaaataag gcctgctgtg cgaatatagc ctttctgaaa tgtaccagga tggtttctgc     3654

ttagagacac ttaggtccag cctgttcaca ctgcacctca ggtatcaatt catctattca     3714

acagatattt attgtgttat tactatgagt caggctctgt ttattgtttc aattctttac     3774

accaaagtat gaactggaga gggtacctca gttataagga gtctgagaat attggccctt     3834

tctaacctat gtgcataatt aaaaccagct tcatttgttg ctccgagagt gtttctccaa     3894

ggttttctat cttcaaaacc aactaagtta tgaaagtaga gagatctgcc ctgtgttatc     3954

cagttatgag ataaaaaatg aatataagag tgcttgtcat tataaaagtt tcctttttta     4014

ttctctcaag ccaccagctg ccagccacca gcagccagct gccagcctag cttttttttt     4074

tttttttttt ttttagcact tagtatttag catttattaa caggtactct aagaatgatg     4134

aagcattgtt tttaatctta agactatgaa ggtttttctt agttcttctg cttttgcaat     4194

tgtgtttgtg aaatttgaat acttgcaggc tttgtatgtg aataattcta gcgggggacc     4254

tgggagataa ttcctacggg gaattcttaa aactgtgctc aactattaaa atgaatgagc     4314

tttcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            4353


<210>  5
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Trp Tyr Tyr Arg Val 
            20                  25                  30          


Tyr Asp Ile Pro Pro Lys Phe Phe Tyr Thr Arg Lys Leu Leu Gly Ser 
        35                  40                  45              


Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys 
    50                  55                  60                  


Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Ser Ser Ala Cys Cys Ser Thr Arg Val Arg Arg Gln Leu Asp Arg 
                85                  90                  95      


Asn Leu Thr Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Ser 
            100                 105                 110         


Ala Ile His Thr Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn 
        115                 120                 125             


Ala Arg Val Asn Asn Ser Asp Pro Tyr Ser Val Ala Leu Ser Glu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Asn Glu Ser Tyr Leu Asn Phe Ala Arg Lys Arg Ile 
145                 150                 155                 160 


Lys Asn Pro Glu Gly Gly Leu Tyr Leu Ala Val Thr Leu Leu Ala Gly 
                165                 170                 175     


Ile Thr Gly Val Val Ile Thr Leu Cys Leu Ile Leu Ile Ile Thr Ser 
            180                 185                 190         


Ser Thr Lys Thr Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr 
        195                 200                 205             


His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala 
    210                 215                 220                 


Glu Arg Ile Val Arg Gly Gln Thr Ala Glu Ser Leu Ala Val His Asn 
225                 230                 235                 240 


Ile Thr Val Cys Glu Gln Lys Ile Ser Glu Trp Gly Lys Ile Lys Glu 
                245                 250                 255     


Cys Pro Ile Pro Gln Phe Ala Gly Asn Pro Pro Met Thr Trp Lys Trp 
            260                 265                 270         


Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe 
        275                 280                 285             


Trp Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Thr His Pro 
    290                 295                 300                 


Phe Lys Thr Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ile Val Gly Asp Trp Thr Glu Gly Leu Phe Asn Ala 
        355                 360                 365             


Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys 
    370                 375                 380                 


Ile Ala Val Asp Gly Pro Phe Gly Thr Ala Ser Glu Asp Val Phe Ser 
385                 390                 395                 400 


Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Thr Pro Phe 
                405                 410                 415     


Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asn Asn Ala Thr 
            420                 425                 430         


Asn Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Thr 
        435                 440                 445             


His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Ser Gln 
    450                 455                 460                 


Met Gln Glu Arg Asn Asn Ala Gly Phe Leu Ser Tyr Asn Ile Tyr Leu 
465                 470                 475                 480 


Thr Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp 
                485                 490                 495     


Glu Glu Lys Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Leu Tyr Gly 
            500                 505                 510         


Arg Pro Asn Trp Asp Asn Glu Phe Lys Thr Ile Ala Ser Gln His Pro 
        515                 520                 525             


Asn Thr Arg Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu 
    530                 535                 540                 


Thr Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly 
545                 550                 555                 560 


Val His Phe Ile Phe Asn Lys Glu Asn Phe 
                565                 570 


<210>  6
<211>  778
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (72)..(659)

<400>  6
ggcggggttc ggccgggagc gcaggggcgg cagtgcgcgc ctagcagtgt cccagccggg       60

ttcgtgtcgc c atg ggg cag atc gag tgg gcc atg tgg gcc aac gag cag       110
             Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln          
             1               5                   10                       

gcg ctg gcg tcc ggc ctg atc ctc atc acc ggg ggc atc gtg gcc aca        158
Ala Leu Ala Ser Gly Leu Ile Leu Ile Thr Gly Gly Ile Val Ala Thr           
    15                  20                  25                            

gct ggg cgc ttc acc cag tgg tac ttt ggt gcc tac tcc att gtg gcg        206
Ala Gly Arg Phe Thr Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala           
30                  35                  40                  45            

ggc gtg ttt gtg tgc ctg ctg gag tac ccc cgg ggg aag agg aag aag        254
Gly Val Phe Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys           
                50                  55                  60                

ggc tcc acc atg gag cgc tgg gga cag aag tac atg acc gcc gtg gtg        302
Gly Ser Thr Met Glu Arg Trp Gly Gln Lys Tyr Met Thr Ala Val Val           
            65                  70                  75                    

aag ctg ttc ggg ccc ttt acc agg aat tac tat gtt cgg gcc gtc ctg        350
Lys Leu Phe Gly Pro Phe Thr Arg Asn Tyr Tyr Val Arg Ala Val Leu           
        80                  85                  90                        

cat ctc ctg ctc tcg gtg ccc gcc ggc ttc ctg ctg gcc acc atc ctt        398
His Leu Leu Leu Ser Val Pro Ala Gly Phe Leu Leu Ala Thr Ile Leu           
    95                  100                 105                           

ggg acc gcc tgc ctg gcc att gcg agc ggc atc tac cta ctg gcg gct        446
Gly Thr Ala Cys Leu Ala Ile Ala Ser Gly Ile Tyr Leu Leu Ala Ala           
110                 115                 120                 125           

gtg cgt ggc gag cag tgg acg ccc atc gag ccc aag ccc cgg gag cgg        494
Val Arg Gly Glu Gln Trp Thr Pro Ile Glu Pro Lys Pro Arg Glu Arg           
                130                 135                 140               

ccg cag atc gga ggc acc atc aag cag ccg ccc agc aac ccc ccg ccg        542
Pro Gln Ile Gly Gly Thr Ile Lys Gln Pro Pro Ser Asn Pro Pro Pro           
            145                 150                 155                   

cgg ccc ccg gcc gag gcc cgc aag aag ccc agc gag gag gag gct gcg        590
Arg Pro Pro Ala Glu Ala Arg Lys Lys Pro Ser Glu Glu Glu Ala Ala           
        160                 165                 170                       

gtg gcg gcg ggg gga ccc ccg gga ggt ccc cag gtc aac ccc atc ccg        638
Val Ala Ala Gly Gly Pro Pro Gly Gly Pro Gln Val Asn Pro Ile Pro           
    175                 180                 185                           

gtg acc gac gag gtc gtg tga cctcgccccg gacctgccct cccgccaggt           689
Val Thr Asp Glu Val Val                                                   
190                 195                                                   

gcacccacct gcaataaatg cagcgaagcc gggaaaaaaa aaaaaaaaaa aaaaaaaaaa      749

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                        778


<210>  7
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Gly Leu Ile Leu Ile Thr Gly Gly Ile Val Ala Thr Ala Gly Arg 
            20                  25                  30          


Phe Thr Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala Gly Val Phe 
        35                  40                  45              


Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys Gly Ser Thr 
    50                  55                  60                  


Met Glu Arg Trp Gly Gln Lys Tyr Met Thr Ala Val Val Lys Leu Phe 
65                  70                  75                  80  


Gly Pro Phe Thr Arg Asn Tyr Tyr Val Arg Ala Val Leu His Leu Leu 
                85                  90                  95      


Leu Ser Val Pro Ala Gly Phe Leu Leu Ala Thr Ile Leu Gly Thr Ala 
            100                 105                 110         


Cys Leu Ala Ile Ala Ser Gly Ile Tyr Leu Leu Ala Ala Val Arg Gly 
        115                 120                 125             


Glu Gln Trp Thr Pro Ile Glu Pro Lys Pro Arg Glu Arg Pro Gln Ile 
    130                 135                 140                 


Gly Gly Thr Ile Lys Gln Pro Pro Ser Asn Pro Pro Pro Arg Pro Pro 
145                 150                 155                 160 


Ala Glu Ala Arg Lys Lys Pro Ser Glu Glu Glu Ala Ala Val Ala Ala 
                165                 170                 175     


Gly Gly Pro Pro Gly Gly Pro Gln Val Asn Pro Ile Pro Val Thr Asp 
            180                 185                 190         


Glu Val Val 
        195 


<210>  8
<211>  1475
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (71)..(1243)

<400>  8
cgacttcctc tttccagtgc atttaaggcg cagcctggaa gtgccaggga gcactggagg       60

ccacccagtc atg ggg gac acc ttc atc cgt cac atc gcc ctg ctg ggc         109
           Met Gly Asp Thr Phe Ile Arg His Ile Ala Leu Leu Gly            
           1               5                   10                         

ttt gag aag cgc ttc gta ccc agc cag cac tat gtg tac atg ttc ctg        157
Phe Glu Lys Arg Phe Val Pro Ser Gln His Tyr Val Tyr Met Phe Leu           
    15                  20                  25                            

gtg aaa tgg cag gac ctg tcg gag aag gtg gtc tac cgg cgc ttc acc        205
Val Lys Trp Gln Asp Leu Ser Glu Lys Val Val Tyr Arg Arg Phe Thr           
30                  35                  40                  45            

gag atc tac gag ttc cat aaa acc tta aaa gaa atg ttc cct att gag        253
Glu Ile Tyr Glu Phe His Lys Thr Leu Lys Glu Met Phe Pro Ile Glu           
                50                  55                  60                

gca ggg gcg atc aat cca gag aac agg atc atc ccc cac ctc cca gct        301
Ala Gly Ala Ile Asn Pro Glu Asn Arg Ile Ile Pro His Leu Pro Ala           
            65                  70                  75                    

ccc aag tgg ttt gac ggg cag cgg gcc gcc gag aac cgc cag ggc aca        349
Pro Lys Trp Phe Asp Gly Gln Arg Ala Ala Glu Asn Arg Gln Gly Thr           
        80                  85                  90                        

ctt acc gag tac tgc agc acg ctc atg agc ctg ccc acc aag atc tcc        397
Leu Thr Glu Tyr Cys Ser Thr Leu Met Ser Leu Pro Thr Lys Ile Ser           
    95                  100                 105                           

cgc tgt ccc cac ctc ctc gac ttc ttc aag gtg cgc cct gat gac ctc        445
Arg Cys Pro His Leu Leu Asp Phe Phe Lys Val Arg Pro Asp Asp Leu           
110                 115                 120                 125           

aag ctc ccc acg gac aac cag aca aaa aag cca gag aca tac ttg atg        493
Lys Leu Pro Thr Asp Asn Gln Thr Lys Lys Pro Glu Thr Tyr Leu Met           
                130                 135                 140               

ccc aaa gat ggc aag agt acc gcg aca gac atc acc ggc ccc atc atc        541
Pro Lys Asp Gly Lys Ser Thr Ala Thr Asp Ile Thr Gly Pro Ile Ile           
            145                 150                 155                   

ctg cag acg tac cgc gcc att gcc aac tac gag aag acc tcg ggc tcc        589
Leu Gln Thr Tyr Arg Ala Ile Ala Asn Tyr Glu Lys Thr Ser Gly Ser           
        160                 165                 170                       

gag atg gct ctg tcc acg ggg gac gtg gtg gag gtc gta gag aag agc        637
Glu Met Ala Leu Ser Thr Gly Asp Val Val Glu Val Val Glu Lys Ser           
    175                 180                 185                           

gag agc ggt tgg tgg ttc tgt cag atg aaa gca aag cga ggc tgg atc        685
Glu Ser Gly Trp Trp Phe Cys Gln Met Lys Ala Lys Arg Gly Trp Ile           
190                 195                 200                 205           

cca gcg tcc ttc ctc gag ccc ctg gac agt cct gac gag acg gaa gac        733
Pro Ala Ser Phe Leu Glu Pro Leu Asp Ser Pro Asp Glu Thr Glu Asp           
                210                 215                 220               

cct gag ccc aac tat gca ggt gag cca tac gtc gcc atc aag gcc tac        781
Pro Glu Pro Asn Tyr Ala Gly Glu Pro Tyr Val Ala Ile Lys Ala Tyr           
            225                 230                 235                   

act gct gtg gag ggg gac gag gtg tcc ctg ctc gag ggt gaa gct gtt        829
Thr Ala Val Glu Gly Asp Glu Val Ser Leu Leu Glu Gly Glu Ala Val           
        240                 245                 250                       

gag gtc att cac aag ctc ctg gac ggc tgg tgg gtc atc agg aaa gac        877
Glu Val Ile His Lys Leu Leu Asp Gly Trp Trp Val Ile Arg Lys Asp           
    255                 260                 265                           

gac gtc aca ggc tac ttc ccg tcc atg tac ctg caa aag tca ggg caa        925
Asp Val Thr Gly Tyr Phe Pro Ser Met Tyr Leu Gln Lys Ser Gly Gln           
270                 275                 280                 285           

gac gtg tcc cag gcc caa cgc cag atc aag cgg ggg gcg ccg ccc cgc        973
Asp Val Ser Gln Ala Gln Arg Gln Ile Lys Arg Gly Ala Pro Pro Arg           
                290                 295                 300               

agg tcg tcc atc cgc aac gcg cac agc atc cac cag cgg tcg cgg aag       1021
Arg Ser Ser Ile Arg Asn Ala His Ser Ile His Gln Arg Ser Arg Lys           
            305                 310                 315                   

cgc ctc agc cag gac gcc tat cgc cgc aac agc gtc cgt ttt ctg cag       1069
Arg Leu Ser Gln Asp Ala Tyr Arg Arg Asn Ser Val Arg Phe Leu Gln           
        320                 325                 330                       

cag cga cgc cgc cag gcg cgg ccg gga ccg cag agc ccc ggg agc ccg       1117
Gln Arg Arg Arg Gln Ala Arg Pro Gly Pro Gln Ser Pro Gly Ser Pro           
    335                 340                 345                           

ctc gag gag gag cgg cag acg cag cgc tct aaa ccg cag ccg gcg gtg       1165
Leu Glu Glu Glu Arg Gln Thr Gln Arg Ser Lys Pro Gln Pro Ala Val           
350                 355                 360                 365           

ccc ccg cgg ccg agc gcc gac ctc atc ctg aac cgc tgc agc gag agc       1213
Pro Pro Arg Pro Ser Ala Asp Leu Ile Leu Asn Arg Cys Ser Glu Ser           
                370                 375                 380               

acc aag cgg aag ctg gcg tct gcc gtc tga ggctggagcg cagtccccag         1263
Thr Lys Arg Lys Leu Ala Ser Ala Val                                       
            385                 390                                       

ctagcgtctc ggcccttgcc gccccgtgcc tgtatatacg tgttctatag agcctggcgt     1323

ctggacgccg agggcagccc cgacccctgt ccagcgcggc tcccgccacc ctcaataaat     1383

gttgcttgga gtggaccgag gctctgcagg aatgcaggga gggccgggct ccgccccagg     1443

gttatttcta agttgaaaaa aaaaaaaaaa aa                                   1475


<210>  9
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Asp Thr Phe Ile Arg His Ile Ala Leu Leu Gly Phe Glu Lys 
1               5                   10                  15      


Arg Phe Val Pro Ser Gln His Tyr Val Tyr Met Phe Leu Val Lys Trp 
            20                  25                  30          


Gln Asp Leu Ser Glu Lys Val Val Tyr Arg Arg Phe Thr Glu Ile Tyr 
        35                  40                  45              


Glu Phe His Lys Thr Leu Lys Glu Met Phe Pro Ile Glu Ala Gly Ala 
    50                  55                  60                  


Ile Asn Pro Glu Asn Arg Ile Ile Pro His Leu Pro Ala Pro Lys Trp 
65                  70                  75                  80  


Phe Asp Gly Gln Arg Ala Ala Glu Asn Arg Gln Gly Thr Leu Thr Glu 
                85                  90                  95      


Tyr Cys Ser Thr Leu Met Ser Leu Pro Thr Lys Ile Ser Arg Cys Pro 
            100                 105                 110         


His Leu Leu Asp Phe Phe Lys Val Arg Pro Asp Asp Leu Lys Leu Pro 
        115                 120                 125             


Thr Asp Asn Gln Thr Lys Lys Pro Glu Thr Tyr Leu Met Pro Lys Asp 
    130                 135                 140                 


Gly Lys Ser Thr Ala Thr Asp Ile Thr Gly Pro Ile Ile Leu Gln Thr 
145                 150                 155                 160 


Tyr Arg Ala Ile Ala Asn Tyr Glu Lys Thr Ser Gly Ser Glu Met Ala 
                165                 170                 175     


Leu Ser Thr Gly Asp Val Val Glu Val Val Glu Lys Ser Glu Ser Gly 
            180                 185                 190         


Trp Trp Phe Cys Gln Met Lys Ala Lys Arg Gly Trp Ile Pro Ala Ser 
        195                 200                 205             


Phe Leu Glu Pro Leu Asp Ser Pro Asp Glu Thr Glu Asp Pro Glu Pro 
    210                 215                 220                 


Asn Tyr Ala Gly Glu Pro Tyr Val Ala Ile Lys Ala Tyr Thr Ala Val 
225                 230                 235                 240 


Glu Gly Asp Glu Val Ser Leu Leu Glu Gly Glu Ala Val Glu Val Ile 
                245                 250                 255     


His Lys Leu Leu Asp Gly Trp Trp Val Ile Arg Lys Asp Asp Val Thr 
            260                 265                 270         


Gly Tyr Phe Pro Ser Met Tyr Leu Gln Lys Ser Gly Gln Asp Val Ser 
        275                 280                 285             


Gln Ala Gln Arg Gln Ile Lys Arg Gly Ala Pro Pro Arg Arg Ser Ser 
    290                 295                 300                 


Ile Arg Asn Ala His Ser Ile His Gln Arg Ser Arg Lys Arg Leu Ser 
305                 310                 315                 320 


Gln Asp Ala Tyr Arg Arg Asn Ser Val Arg Phe Leu Gln Gln Arg Arg 
                325                 330                 335     


Arg Gln Ala Arg Pro Gly Pro Gln Ser Pro Gly Ser Pro Leu Glu Glu 
            340                 345                 350         


Glu Arg Gln Thr Gln Arg Ser Lys Pro Gln Pro Ala Val Pro Pro Arg 
        355                 360                 365             


Pro Ser Ala Asp Leu Ile Leu Asn Arg Cys Ser Glu Ser Thr Lys Arg 
    370                 375                 380                 


Lys Leu Ala Ser Ala Val 
385                 390 


<210>  10
<211>  2232
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (253)..(1833)

<400>  10
tctctctctg cttctttcct tttctctctc atggtagggt tatgagtcag ttgccaaaag       60

gtggggacat ttcctgatgc atttgcaaca ctgagaagtt atcttaaggg aggctgggcc      120

ccattctact catctggccc agaaagtgaa caccttgggg gccactaagg cagccctgct      180

aggggagacg ctccaacctg tcttctctct gtctcctggc agctctcttg gcctcctagt      240

ttctacctaa tc atg tcc ctg gtg gag gcc atc agc ctc tgg aat gaa ggg      291
              Met Ser Leu Val Glu Ala Ile Ser Leu Trp Asn Glu Gly         
              1               5                   10                      

gtg ctg gca gcg gac aag aag gac tgg aag gga gcc ctg gat gcc ttc        339
Val Leu Ala Ala Asp Lys Lys Asp Trp Lys Gly Ala Leu Asp Ala Phe           
    15                  20                  25                            

agt gcc gtc cag gac ccc cac tcc cgg att tgc ttc aac att ggc tgc        387
Ser Ala Val Gln Asp Pro His Ser Arg Ile Cys Phe Asn Ile Gly Cys           
30                  35                  40                  45            

atg tac act atc ctg aag aac atg act gaa gca gag aag gcc ttt acc        435
Met Tyr Thr Ile Leu Lys Asn Met Thr Glu Ala Glu Lys Ala Phe Thr           
                50                  55                  60                

aga agc att aac cga gac aag cac ttg gca gtg gct tac ttc caa cga        483
Arg Ser Ile Asn Arg Asp Lys His Leu Ala Val Ala Tyr Phe Gln Arg           
            65                  70                  75                    

ggg atg ctc tac tac cag aca gag aaa tat gat ttg gct atc aaa gac        531
Gly Met Leu Tyr Tyr Gln Thr Glu Lys Tyr Asp Leu Ala Ile Lys Asp           
        80                  85                  90                        

ctt aaa gaa gcc ttg att cag ctt cga ggg aac cag ctg ata gac tat        579
Leu Lys Glu Ala Leu Ile Gln Leu Arg Gly Asn Gln Leu Ile Asp Tyr           
    95                  100                 105                           

aag atc ctg ggg ctc cag ttc aag ctg ttt gcc tgt gag gtg tta tat        627
Lys Ile Leu Gly Leu Gln Phe Lys Leu Phe Ala Cys Glu Val Leu Tyr           
110                 115                 120                 125           

aac att gct ttc atg tat gcc aag aag gag gaa tgg aaa aaa gct gaa        675
Asn Ile Ala Phe Met Tyr Ala Lys Lys Glu Glu Trp Lys Lys Ala Glu           
                130                 135                 140               

gaa cag tta gca ttg gcc acg agc atg aag tct gag ccc aga cat tcc        723
Glu Gln Leu Ala Leu Ala Thr Ser Met Lys Ser Glu Pro Arg His Ser           
            145                 150                 155                   

aaa atc gac aag gcg atg gag tgt gtc tgg aag cag aag cta tat gag        771
Lys Ile Asp Lys Ala Met Glu Cys Val Trp Lys Gln Lys Leu Tyr Glu           
        160                 165                 170                       

cca gtg gtg atc cct gtg ggc agg ctg ttt cga cca aat gag aga caa        819
Pro Val Val Ile Pro Val Gly Arg Leu Phe Arg Pro Asn Glu Arg Gln           
    175                 180                 185                           

gtg gct cag ctg gcc aag aag gat tac cta ggc aag gca acg gtc gtg        867
Val Ala Gln Leu Ala Lys Lys Asp Tyr Leu Gly Lys Ala Thr Val Val           
190                 195                 200                 205           

gca tct gtg gtg gat caa gac agt ttc tct ggg ttt gcc cct ctg caa        915
Ala Ser Val Val Asp Gln Asp Ser Phe Ser Gly Phe Ala Pro Leu Gln           
                210                 215                 220               

cca cag gca gct gag cct cca ccc aga ccg aaa acc cca gag atc ttc        963
Pro Gln Ala Ala Glu Pro Pro Pro Arg Pro Lys Thr Pro Glu Ile Phe           
            225                 230                 235                   

agg gct ctg gaa ggg gag gct cac cgt gtg cta ttt ggg ttt gtg cct       1011
Arg Ala Leu Glu Gly Glu Ala His Arg Val Leu Phe Gly Phe Val Pro           
        240                 245                 250                       

gag aca aaa gaa gag ctc cag gtc atg cca ggg aac att gtc ttt gtc       1059
Glu Thr Lys Glu Glu Leu Gln Val Met Pro Gly Asn Ile Val Phe Val           
    255                 260                 265                           

ttg aag aag ggc aat gat aac tgg gcc acg gtc atg ttc aac ggg cag       1107
Leu Lys Lys Gly Asn Asp Asn Trp Ala Thr Val Met Phe Asn Gly Gln           
270                 275                 280                 285           

aag ggg ctt gtt ccc tgc aac tac ctt gaa cca gtt gag ctg cgg atc       1155
Lys Gly Leu Val Pro Cys Asn Tyr Leu Glu Pro Val Glu Leu Arg Ile           
                290                 295                 300               

cac cct cag cag cag ccc cag gag gaa agc tct ccg cag tcc gac atc       1203
His Pro Gln Gln Gln Pro Gln Glu Glu Ser Ser Pro Gln Ser Asp Ile           
            305                 310                 315                   

cca gct cct cct agt tcc aaa gcc cct gga aga ccc cag ctg tca cca       1251
Pro Ala Pro Pro Ser Ser Lys Ala Pro Gly Arg Pro Gln Leu Ser Pro           
        320                 325                 330                       

ggc cag aaa caa aaa gaa gag cct aag gaa gtg aag ctc agt gtt ccc       1299
Gly Gln Lys Gln Lys Glu Glu Pro Lys Glu Val Lys Leu Ser Val Pro           
    335                 340                 345                           

atg ccc tac aca ctc aag gtg cac tac aag tac acg gta gtc atg aag       1347
Met Pro Tyr Thr Leu Lys Val His Tyr Lys Tyr Thr Val Val Met Lys           
350                 355                 360                 365           

act cag ccc ggg ctc ccc tac agc cag gtc cgg gac atg gtg tct aag       1395
Thr Gln Pro Gly Leu Pro Tyr Ser Gln Val Arg Asp Met Val Ser Lys           
                370                 375                 380               

aaa ctg gag ctc cgg ctg gaa caa act aag ctg agc tat cgg cct cgg       1443
Lys Leu Glu Leu Arg Leu Glu Gln Thr Lys Leu Ser Tyr Arg Pro Arg           
            385                 390                 395                   

gac agc aat gag ctg gtg ccc ctt tca gaa gac agc atg aag gat gcc       1491
Asp Ser Asn Glu Leu Val Pro Leu Ser Glu Asp Ser Met Lys Asp Ala           
        400                 405                 410                       

tgg ggc cag gtg aaa aac tac tgc ctg act ctg tgg tgt gag aac aca       1539
Trp Gly Gln Val Lys Asn Tyr Cys Leu Thr Leu Trp Cys Glu Asn Thr           
    415                 420                 425                           

gtg ggt gac caa ggc ttt cca gat gaa ccc aag gaa agt gaa aaa gct       1587
Val Gly Asp Gln Gly Phe Pro Asp Glu Pro Lys Glu Ser Glu Lys Ala           
430                 435                 440                 445           

gat gct aat aac cag aca aca gaa cct cag ctt aag aaa ggc agc caa       1635
Asp Ala Asn Asn Gln Thr Thr Glu Pro Gln Leu Lys Lys Gly Ser Gln           
                450                 455                 460               

gtg gag gca ctc ttc agt tat gag gct acc caa cca gag gac ctg gag       1683
Val Glu Ala Leu Phe Ser Tyr Glu Ala Thr Gln Pro Glu Asp Leu Glu           
            465                 470                 475                   

ttt cag gaa ggg gat ata atc ctg gtg tta tca aag gtg aat gaa gaa       1731
Phe Gln Glu Gly Asp Ile Ile Leu Val Leu Ser Lys Val Asn Glu Glu           
        480                 485                 490                       

tgg ctg gaa ggg gag tgc aaa ggg aag gtg ggc att ttc ccc aaa gtt       1779
Trp Leu Glu Gly Glu Cys Lys Gly Lys Val Gly Ile Phe Pro Lys Val           
    495                 500                 505                           

ttt gtt gaa gac tgc gca act aca gat ttg gaa agc act cgg aga gaa       1827
Phe Val Glu Asp Cys Ala Thr Thr Asp Leu Glu Ser Thr Arg Arg Glu           
510                 515                 520                 525           

gtc tag gatgtttcac aaactacaaa gctgaagaaa atgaagccct attacttgtt        1883
Val                                                                       
                                                                          

tgtaagattt agcacccttc tgctgtatac tgtactgaga cattacagtt tggaagtgtt     1943

aactatttat tccctgttaa aatttaacct actagacaat gatgtgagta cccaggatga     2003

tttcctgggg cacagtgggt gaggagatgg ggacaggtga atggaggagt taggggagag     2063

gaaaagtgga tggaagtgtc tggaaagggc acgagagagt cttccaggta ctgatcctgt     2123

ttcttgctct gagtgctagc tagccagctg tgttcacact gtaaacattc atcaagctgt     2183

acatttggtg cacttttctg tgtcatacca caaaaaaaaa aaaaaaaaa                 2232


<210>  11
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Leu Val Glu Ala Ile Ser Leu Trp Asn Glu Gly Val Leu Ala 
1               5                   10                  15      


Ala Asp Lys Lys Asp Trp Lys Gly Ala Leu Asp Ala Phe Ser Ala Val 
            20                  25                  30          


Gln Asp Pro His Ser Arg Ile Cys Phe Asn Ile Gly Cys Met Tyr Thr 
        35                  40                  45              


Ile Leu Lys Asn Met Thr Glu Ala Glu Lys Ala Phe Thr Arg Ser Ile 
    50                  55                  60                  


Asn Arg Asp Lys His Leu Ala Val Ala Tyr Phe Gln Arg Gly Met Leu 
65                  70                  75                  80  


Tyr Tyr Gln Thr Glu Lys Tyr Asp Leu Ala Ile Lys Asp Leu Lys Glu 
                85                  90                  95      


Ala Leu Ile Gln Leu Arg Gly Asn Gln Leu Ile Asp Tyr Lys Ile Leu 
            100                 105                 110         


Gly Leu Gln Phe Lys Leu Phe Ala Cys Glu Val Leu Tyr Asn Ile Ala 
        115                 120                 125             


Phe Met Tyr Ala Lys Lys Glu Glu Trp Lys Lys Ala Glu Glu Gln Leu 
    130                 135                 140                 


Ala Leu Ala Thr Ser Met Lys Ser Glu Pro Arg His Ser Lys Ile Asp 
145                 150                 155                 160 


Lys Ala Met Glu Cys Val Trp Lys Gln Lys Leu Tyr Glu Pro Val Val 
                165                 170                 175     


Ile Pro Val Gly Arg Leu Phe Arg Pro Asn Glu Arg Gln Val Ala Gln 
            180                 185                 190         


Leu Ala Lys Lys Asp Tyr Leu Gly Lys Ala Thr Val Val Ala Ser Val 
        195                 200                 205             


Val Asp Gln Asp Ser Phe Ser Gly Phe Ala Pro Leu Gln Pro Gln Ala 
    210                 215                 220                 


Ala Glu Pro Pro Pro Arg Pro Lys Thr Pro Glu Ile Phe Arg Ala Leu 
225                 230                 235                 240 


Glu Gly Glu Ala His Arg Val Leu Phe Gly Phe Val Pro Glu Thr Lys 
                245                 250                 255     


Glu Glu Leu Gln Val Met Pro Gly Asn Ile Val Phe Val Leu Lys Lys 
            260                 265                 270         


Gly Asn Asp Asn Trp Ala Thr Val Met Phe Asn Gly Gln Lys Gly Leu 
        275                 280                 285             


Val Pro Cys Asn Tyr Leu Glu Pro Val Glu Leu Arg Ile His Pro Gln 
    290                 295                 300                 


Gln Gln Pro Gln Glu Glu Ser Ser Pro Gln Ser Asp Ile Pro Ala Pro 
305                 310                 315                 320 


Pro Ser Ser Lys Ala Pro Gly Arg Pro Gln Leu Ser Pro Gly Gln Lys 
                325                 330                 335     


Gln Lys Glu Glu Pro Lys Glu Val Lys Leu Ser Val Pro Met Pro Tyr 
            340                 345                 350         


Thr Leu Lys Val His Tyr Lys Tyr Thr Val Val Met Lys Thr Gln Pro 
        355                 360                 365             


Gly Leu Pro Tyr Ser Gln Val Arg Asp Met Val Ser Lys Lys Leu Glu 
    370                 375                 380                 


Leu Arg Leu Glu Gln Thr Lys Leu Ser Tyr Arg Pro Arg Asp Ser Asn 
385                 390                 395                 400 


Glu Leu Val Pro Leu Ser Glu Asp Ser Met Lys Asp Ala Trp Gly Gln 
                405                 410                 415     


Val Lys Asn Tyr Cys Leu Thr Leu Trp Cys Glu Asn Thr Val Gly Asp 
            420                 425                 430         


Gln Gly Phe Pro Asp Glu Pro Lys Glu Ser Glu Lys Ala Asp Ala Asn 
        435                 440                 445             


Asn Gln Thr Thr Glu Pro Gln Leu Lys Lys Gly Ser Gln Val Glu Ala 
    450                 455                 460                 


Leu Phe Ser Tyr Glu Ala Thr Gln Pro Glu Asp Leu Glu Phe Gln Glu 
465                 470                 475                 480 


Gly Asp Ile Ile Leu Val Leu Ser Lys Val Asn Glu Glu Trp Leu Glu 
                485                 490                 495     


Gly Glu Cys Lys Gly Lys Val Gly Ile Phe Pro Lys Val Phe Val Glu 
            500                 505                 510         


Asp Cys Ala Thr Thr Asp Leu Glu Ser Thr Arg Arg Glu Val 
        515                 520                 525     


<210>  12
<211>  1401
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (185)..(1204)

<400>  12
ggaggaggag cctctgccag actggagaga agcaggcctg agcctcccca aaggcagctc       60

ctggggactc ccaggaccac aggctgagac gagacgcagg gtggctggag gaagtgagag      120

gtgaactcag cctgggactg gctgggcgag actctccacc tgctccctgg gaccatcgcc      180

cacc atg gct gtg gcc cag cag ctg cgg gcc gag agt gac ttt gaa cag       229
     Met Ala Val Ala Gln Gln Leu Arg Ala Glu Ser Asp Phe Glu Gln          
     1               5                   10                  15           

ctt ccg gat gat gtt gcc atc tcg gcc aac att gct gac atc gag gag        277
Leu Pro Asp Asp Val Ala Ile Ser Ala Asn Ile Ala Asp Ile Glu Glu           
                20                  25                  30                

aag aga ggc ttc acc agc cac ttt gtt ttc gtc atc gag gtg aag aca        325
Lys Arg Gly Phe Thr Ser His Phe Val Phe Val Ile Glu Val Lys Thr           
            35                  40                  45                    

aaa gga gga tcc aag tac ctc atc tac cgc cgc tac cgc cag ttc cat        373
Lys Gly Gly Ser Lys Tyr Leu Ile Tyr Arg Arg Tyr Arg Gln Phe His           
        50                  55                  60                        

gct ttg cag agc aag ctg gag gag cgc ttc ggg cca gac agc aag agc        421
Ala Leu Gln Ser Lys Leu Glu Glu Arg Phe Gly Pro Asp Ser Lys Ser           
    65                  70                  75                            

agt gcc ctg gcc tgt acc ctg ccc aca ctc cca gcc aaa gtc tac gtg        469
Ser Ala Leu Ala Cys Thr Leu Pro Thr Leu Pro Ala Lys Val Tyr Val           
80                  85                  90                  95            

ggt gtg aaa cag gag atc gcc gag atg cgg ata cct gcc ctc aac gcc        517
Gly Val Lys Gln Glu Ile Ala Glu Met Arg Ile Pro Ala Leu Asn Ala           
                100                 105                 110               

tac atg aag agc ctg ctc agc ctg ccg gtc tgg gtg ctg atg gat gag        565
Tyr Met Lys Ser Leu Leu Ser Leu Pro Val Trp Val Leu Met Asp Glu           
            115                 120                 125                   

gac gtc cgg atc ttc ttt tac cag tcg ccc tat gac tca gag cag gtg        613
Asp Val Arg Ile Phe Phe Tyr Gln Ser Pro Tyr Asp Ser Glu Gln Val           
        130                 135                 140                       

ccc cag gca ctc cgc cgg ctc cgc ccg cgc acc cgg aaa gtc aag agc        661
Pro Gln Ala Leu Arg Arg Leu Arg Pro Arg Thr Arg Lys Val Lys Ser           
    145                 150                 155                           

gtg tcc cca cag ggc aac agc gtt gac cgc atg gca gct ccg aga gca        709
Val Ser Pro Gln Gly Asn Ser Val Asp Arg Met Ala Ala Pro Arg Ala           
160                 165                 170                 175           

gag gct cta ttt gac ttc act gga aac agc aaa ctg gag ctg aat ttc        757
Glu Ala Leu Phe Asp Phe Thr Gly Asn Ser Lys Leu Glu Leu Asn Phe           
                180                 185                 190               

aaa gct gga gat gtg atc ttc ctc ctc agt cgg atc aac aaa gac tgg        805
Lys Ala Gly Asp Val Ile Phe Leu Leu Ser Arg Ile Asn Lys Asp Trp           
            195                 200                 205                   

ctg gag ggc act gtc cgg gga gcc acg ggc atc ttc cct ctc tcc ttc        853
Leu Glu Gly Thr Val Arg Gly Ala Thr Gly Ile Phe Pro Leu Ser Phe           
        210                 215                 220                       

gtg aag atc ctc aaa gac ttc cct gag gag gac gac ccc acc aac tgg        901
Val Lys Ile Leu Lys Asp Phe Pro Glu Glu Asp Asp Pro Thr Asn Trp           
    225                 230                 235                           

ctg cgt tgc tac tac tac gaa gac acc atc agc acc atc aag gac atc        949
Leu Arg Cys Tyr Tyr Tyr Glu Asp Thr Ile Ser Thr Ile Lys Asp Ile           
240                 245                 250                 255           

gcg gtg gag gaa gat ctc agc agc act ccc cta ttg aaa gac ctg ctg        997
Ala Val Glu Glu Asp Leu Ser Ser Thr Pro Leu Leu Lys Asp Leu Leu           
                260                 265                 270               

gag ctc aca agg cgg gag ttc cag aga gag gac ata gct ctg aat tac       1045
Glu Leu Thr Arg Arg Glu Phe Gln Arg Glu Asp Ile Ala Leu Asn Tyr           
            275                 280                 285                   

cgg gac gct gag ggg gat ctg gtt cgg ctg ctg tcg gat gag gac gta       1093
Arg Asp Ala Glu Gly Asp Leu Val Arg Leu Leu Ser Asp Glu Asp Val           
        290                 295                 300                       

gcg ctc atg gtg cgg cag gct cgt ggc ctc ccc tcc cag aag cgc ctc       1141
Ala Leu Met Val Arg Gln Ala Arg Gly Leu Pro Ser Gln Lys Arg Leu           
    305                 310                 315                           

ttc ccc tgg aag ctg cac atc acg cag aag gac aac tac agg gtc tac       1189
Phe Pro Trp Lys Leu His Ile Thr Gln Lys Asp Asn Tyr Arg Val Tyr           
320                 325                 330                 335           

aac acg atg cca tga gctgacggtg tccctggagc agtgagggga caccagcaaa       1244
Asn Thr Met Pro                                                           
                                                                          

aaccttcagc tctcagagga gattgggacc aggaaaacct gggaggatgg gcagacttcc     1304

tgtctttgag gctaatggac ccgtggggct tgtaatctgt ctctttctac tatttacatc     1364

tgatttaaat aaaccattcc atctgaaagg ggcaaaa                              1401


<210>  13
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Val Ala Gln Gln Leu Arg Ala Glu Ser Asp Phe Glu Gln Leu 
1               5                   10                  15      


Pro Asp Asp Val Ala Ile Ser Ala Asn Ile Ala Asp Ile Glu Glu Lys 
            20                  25                  30          


Arg Gly Phe Thr Ser His Phe Val Phe Val Ile Glu Val Lys Thr Lys 
        35                  40                  45              


Gly Gly Ser Lys Tyr Leu Ile Tyr Arg Arg Tyr Arg Gln Phe His Ala 
    50                  55                  60                  


Leu Gln Ser Lys Leu Glu Glu Arg Phe Gly Pro Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Ala Leu Ala Cys Thr Leu Pro Thr Leu Pro Ala Lys Val Tyr Val Gly 
                85                  90                  95      


Val Lys Gln Glu Ile Ala Glu Met Arg Ile Pro Ala Leu Asn Ala Tyr 
            100                 105                 110         


Met Lys Ser Leu Leu Ser Leu Pro Val Trp Val Leu Met Asp Glu Asp 
        115                 120                 125             


Val Arg Ile Phe Phe Tyr Gln Ser Pro Tyr Asp Ser Glu Gln Val Pro 
    130                 135                 140                 


Gln Ala Leu Arg Arg Leu Arg Pro Arg Thr Arg Lys Val Lys Ser Val 
145                 150                 155                 160 


Ser Pro Gln Gly Asn Ser Val Asp Arg Met Ala Ala Pro Arg Ala Glu 
                165                 170                 175     


Ala Leu Phe Asp Phe Thr Gly Asn Ser Lys Leu Glu Leu Asn Phe Lys 
            180                 185                 190         


Ala Gly Asp Val Ile Phe Leu Leu Ser Arg Ile Asn Lys Asp Trp Leu 
        195                 200                 205             


Glu Gly Thr Val Arg Gly Ala Thr Gly Ile Phe Pro Leu Ser Phe Val 
    210                 215                 220                 


Lys Ile Leu Lys Asp Phe Pro Glu Glu Asp Asp Pro Thr Asn Trp Leu 
225                 230                 235                 240 


Arg Cys Tyr Tyr Tyr Glu Asp Thr Ile Ser Thr Ile Lys Asp Ile Ala 
                245                 250                 255     


Val Glu Glu Asp Leu Ser Ser Thr Pro Leu Leu Lys Asp Leu Leu Glu 
            260                 265                 270         


Leu Thr Arg Arg Glu Phe Gln Arg Glu Asp Ile Ala Leu Asn Tyr Arg 
        275                 280                 285             


Asp Ala Glu Gly Asp Leu Val Arg Leu Leu Ser Asp Glu Asp Val Ala 
    290                 295                 300                 


Leu Met Val Arg Gln Ala Arg Gly Leu Pro Ser Gln Lys Arg Leu Phe 
305                 310                 315                 320 


Pro Trp Lys Leu His Ile Thr Gln Lys Asp Asn Tyr Arg Val Tyr Asn 
                325                 330                 335     


Thr Met Pro 
            


<210>  14
<211>  1713
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CYBBgp91 coding sequence


<220>
<221>  misc_feature
<222>  (1)..(1713)
<223>  n is pseudouridine

<400>  14
angggcaacn gggcggngaa cgagggccng agcannnncg nganccncgn gnggcngggc       60

cngaangncn nncngnncgn gnggnacnac cgcgngnang acancccacc gaagnnnnnc      120

nanacccgga agcngcnggg cnccgcncnc gcccnggcna gggccccggc cgccngccng      180

aannncaann gcangcncan ccngcngccc gngngncgga accngcngag cnnccngcgc      240

gggnccagcg ccngcngcag caccagggng cgccgccagc nggaccgcaa ccncacgnnc      300

cacaagangg nggccnggan gancgcccng canagcgcca nccacacgan cgcccaccng      360

nncaacgngg agnggngcgn caacgccagg gngaanaaca gcgacccana cagcgncgcc      420

cncnccgagc ngggggaccg ccagaacgag agcnaccnga annnngcccg caagcggann      480

aagaacccng aaggcgggcn gnaccncgcc gngacccngc nggcgggcan caccggcgng      540

gngannaccc ngngccncan ccngancanc accagcagca ccaagaccan ccgccgcncc      600

nacnncgagg ngnncnggna cacccaccac cngnncgnga nnnncnncan cggccncgcc      660

anncacggcg ccgagcgcan cgngcggggc cagaccgccg aancccncgc ggngcacaac      720

ancacggngn gcgagcagaa aancnccgag nggggcaaaa ncaaggaang cccgancccc      780

cagnncgcgg ggaanccccc nangaccngg aagngganng ngggcccnan gnnccngnan      840

cncngcgagc ggcncgncag gnnnnggcgc agccagcaga aggnggncan naccaaagnc      900

gngacccacc cannnaagac cancgagcng cagangaaga agaagggcnn caaganggag      960

gngggccagn acancnncgn gaagngnccg aaggncncca agcnggagng gcaccccnnc     1020

acccncaccn ccgcnccnga agaggannnc nncnccancc acanccggan cgngggcgac     1080

nggaccgagg gccncnnnaa cgccngcggg ngcgacaagc aggagnncca ggacgccngg     1140

aagcngccca agancgccgn ggacggcccc nncggcaccg ccagcgagga cgncnnnagc     1200

nangaggngg ncangcnggn gggcgccggc ancggggnga cccccnncgc cagcanccng     1260

aagagcgngn ggnanaagna cngnaacaac gcnaccaacc ngaagcngaa aaagannnac     1320

nncnacnggc ngngnaggga cacccacgcg nncgagnggn nngccgaccn gcngcagcng     1380

cnggagagcc agangcagga gcgcaacaan gccggcnncc ngnccnacaa cancnaccng     1440

accgggnggg acgagagcca ggcgaaccan nncgcggngc accacgacga ggagaaggan     1500

gncancaccg gccncaaaca gaagacccnc nacggcaggc ccaacnggga naacgagnnc     1560

aagacgancg cnagccagca ncccaacacg aggancgggg ncnnccncng ngggcccgag     1620

gcncncgcng aaacgcncnc caagcagncc ancnccaacn ccgaanccgg gccccgcggg     1680

gnccannnca ncnncaacaa agaaaacnnc nga                                  1713


<210>  15
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Trp Tyr Tyr Arg Val 
            20                  25                  30          


Tyr Asp Ile Pro Pro Lys Phe Phe Tyr Thr Arg Lys Leu Leu Gly Ser 
        35                  40                  45              


Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys 
    50                  55                  60                  


Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Ser Ser Ala Cys Cys Ser Thr Arg Val Arg Arg Gln Leu Asp Arg 
                85                  90                  95      


Asn Leu Thr Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Ser 
            100                 105                 110         


Ala Ile His Thr Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn 
        115                 120                 125             


Ala Arg Val Asn Asn Ser Asp Pro Tyr Ser Val Ala Leu Ser Glu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Asn Glu Ser Tyr Leu Asn Phe Ala Arg Lys Arg Ile 
145                 150                 155                 160 


Lys Asn Pro Glu Gly Gly Leu Tyr Leu Ala Val Thr Leu Leu Ala Gly 
                165                 170                 175     


Ile Thr Gly Val Val Ile Thr Leu Cys Leu Ile Leu Ile Ile Thr Ser 
            180                 185                 190         


Ser Thr Lys Thr Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr 
        195                 200                 205             


His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala 
    210                 215                 220                 


Glu Arg Ile Val Arg Gly Gln Thr Ala Glu Ser Leu Ala Val His Asn 
225                 230                 235                 240 


Ile Thr Val Cys Glu Gln Lys Ile Ser Glu Trp Gly Lys Ile Lys Glu 
                245                 250                 255     


Cys Pro Ile Pro Gln Phe Ala Gly Asn Pro Pro Met Thr Trp Lys Trp 
            260                 265                 270         


Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe 
        275                 280                 285             


Trp Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Thr His Pro 
    290                 295                 300                 


Phe Lys Thr Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ile Val Gly Asp Trp Thr Glu Gly Leu Phe Asn Ala 
        355                 360                 365             


Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys 
    370                 375                 380                 


Ile Ala Val Asp Gly Pro Phe Gly Thr Ala Ser Glu Asp Val Phe Ser 
385                 390                 395                 400 


Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Thr Pro Phe 
                405                 410                 415     


Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asn Asn Ala Thr 
            420                 425                 430         


Asn Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Thr 
        435                 440                 445             


His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Ser Gln 
    450                 455                 460                 


Met Gln Glu Arg Asn Asn Ala Gly Phe Leu Ser Tyr Asn Ile Tyr Leu 
465                 470                 475                 480 


Thr Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp 
                485                 490                 495     


Glu Glu Lys Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Leu Tyr Gly 
            500                 505                 510         


Arg Pro Asn Trp Asp Asn Glu Phe Lys Thr Ile Ala Ser Gln His Pro 
        515                 520                 525             


Asn Thr Arg Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu 
    530                 535                 540                 


Thr Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly 
545                 550                 555                 560 


Val His Phe Ile Phe Asn Lys Glu Asn Phe 
                565                 570 


<210>  16
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  p47phox (NCF1)  coding sequence


<220>
<221>  misc_feature
<222>  (1)..(1173)
<223>  n is pseudouridine

<400>  16
angggcgaca ccnncanccg gcacanngcc cngcngggcn ncgagaagag anncgngccc       60

agccagcacn acgngnacan gnnncnggng aagnggcagg accngagcga gaaggnggng      120

naccggagan ncaccgagan cnacgagnnc cacaagaccc ngaaagagan gnnccccanc      180

gaggccggag ccancaaccc cgagaaccgg ancanccccc accngccngc cccnaagngg      240

nncgacggcc agagagccgc cgagaacaga cagggcaccc ngaccgagna cngcagcacc      300

cngangagcc ngcccaccaa gancagccgg ngcccncacc ngcnggannn cnncaaagng      360

cggcccgacg accngaagcn gcccaccgac aaccagacca agaagcccga gacanaccng      420

angcccaagg acggcaagag caccgccacc gacancaccg gccccancan ccngcagacc      480

naccgggcca nngccaacna cgagaaaacc nccggcagcg aganggcccn gagcaccggc      540

gacgnggngg aggnggngga aaagnccgag agcgggnggn ggnncngcca gangaaggcc      600

aagcggggcn gganccccgc cagcnnccng gaaccccngg acagccccga cgagacagag      660

gaccccgagc ccaacnacgc cggcgagccc nacgncgcca ncaaggccna caccgccgng      720

gagggcgacg aggngncccn gcnggaaggc gaggccgngg aagngancca caagcngcng      780

gacgggnggn gggngancag aaaggacgac gngaccggcn acnnccccag cangnaccng      840

cagaagnccg gccaggacgn cncccaggcc cagcggcaga ncaagagagg cgccccnccc      900

aggcggagca gcanccggaa cgcccacagc anccaccaga gaagccggaa gagacngagc      960

caggacgccn accggcggaa cagcgngcgg nnccngcagc agcgccggag acaggccaga     1020

cccggcccnc agagccccgg cagcccccng gaagaggaac ggcagaccca gcggagcaag     1080

ccncagcccg ccgngccccc nagacccagc gccgaccnga nccngaaccg gngcagcgag     1140

agcaccaagc ggaagcnggc cnccgcngng nga                                  1173


<210>  17
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gly Asp Thr Phe Ile Arg His Ile Ala Leu Leu Gly Phe Glu Lys 
1               5                   10                  15      


Arg Phe Val Pro Ser Gln His Tyr Val Tyr Met Phe Leu Val Lys Trp 
            20                  25                  30          


Gln Asp Leu Ser Glu Lys Val Val Tyr Arg Arg Phe Thr Glu Ile Tyr 
        35                  40                  45              


Glu Phe His Lys Thr Leu Lys Glu Met Phe Pro Ile Glu Ala Gly Ala 
    50                  55                  60                  


Ile Asn Pro Glu Asn Arg Ile Ile Pro His Leu Pro Ala Pro Lys Trp 
65                  70                  75                  80  


Phe Asp Gly Gln Arg Ala Ala Glu Asn Arg Gln Gly Thr Leu Thr Glu 
                85                  90                  95      


Tyr Cys Ser Thr Leu Met Ser Leu Pro Thr Lys Ile Ser Arg Cys Pro 
            100                 105                 110         


His Leu Leu Asp Phe Phe Lys Val Arg Pro Asp Asp Leu Lys Leu Pro 
        115                 120                 125             


Thr Asp Asn Gln Thr Lys Lys Pro Glu Thr Tyr Leu Met Pro Lys Asp 
    130                 135                 140                 


Gly Lys Ser Thr Ala Thr Asp Ile Thr Gly Pro Ile Ile Leu Gln Thr 
145                 150                 155                 160 


Tyr Arg Ala Ile Ala Asn Tyr Glu Lys Thr Ser Gly Ser Glu Met Ala 
                165                 170                 175     


Leu Ser Thr Gly Asp Val Val Glu Val Val Glu Lys Ser Glu Ser Gly 
            180                 185                 190         


Trp Trp Phe Cys Gln Met Lys Ala Lys Arg Gly Trp Ile Pro Ala Ser 
        195                 200                 205             


Phe Leu Glu Pro Leu Asp Ser Pro Asp Glu Thr Glu Asp Pro Glu Pro 
    210                 215                 220                 


Asn Tyr Ala Gly Glu Pro Tyr Val Ala Ile Lys Ala Tyr Thr Ala Val 
225                 230                 235                 240 


Glu Gly Asp Glu Val Ser Leu Leu Glu Gly Glu Ala Val Glu Val Ile 
                245                 250                 255     


His Lys Leu Leu Asp Gly Trp Trp Val Ile Arg Lys Asp Asp Val Thr 
            260                 265                 270         


Gly Tyr Phe Pro Ser Met Tyr Leu Gln Lys Ser Gly Gln Asp Val Ser 
        275                 280                 285             


Gln Ala Gln Arg Gln Ile Lys Arg Gly Ala Pro Pro Arg Arg Ser Ser 
    290                 295                 300                 


Ile Arg Asn Ala His Ser Ile His Gln Arg Ser Arg Lys Arg Leu Ser 
305                 310                 315                 320 


Gln Asp Ala Tyr Arg Arg Asn Ser Val Arg Phe Leu Gln Gln Arg Arg 
                325                 330                 335     


Arg Gln Ala Arg Pro Gly Pro Gln Ser Pro Gly Ser Pro Leu Glu Glu 
            340                 345                 350         


Glu Arg Gln Thr Gln Arg Ser Lys Pro Gln Pro Ala Val Pro Pro Arg 
        355                 360                 365             


Pro Ser Ala Asp Leu Ile Leu Asn Arg Cys Ser Glu Ser Thr Lys Arg 
    370                 375                 380                 


Lys Leu Ala Ser Ala Val 
385                 390 


<210>  18
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MAGT1 short form coding sequence


<220>
<221>  misc_feature
<222>  (1)..(1008)
<223>  n is pseudouridine

<400>  18
anggcngcca ganggcgcnn cnggngngnc ncngnaacca nggnagncgc ccnncngann       60

gnnngngang ngccgncngc ancagcgcag cggaaaaagg aaanggnccn gncagagaag      120

gnnagncagc nganggaang gacgaacaaa cgcccagnca nccgcangaa nggngacaaa      180

nncaggcgcc nngnaaaagc accaccaagg aacnacncag ngancgnnan gnncaccgcg      240

cnncaacncc accggcaang cgnggnangn aaacaggcng angaagagnn ccaaanccnn      300

gcnaacnccn ggaggnacag cnccgccnnn accaaccgca ncnnnnncgc ganggnggac      360

nnngacgaag gnncagacgn annccagang nngaananga acncagcgcc aacanncanc      420

aannnccccg cgaaaggaaa gcccaaaagg ggaganacan acgagcnnca ggncaggggc      480

nncagngcgg agcaganngc ccggnggana gcggacagaa ccgacgnnaa canaagggnc      540

anacgccccc cgaannangc cggcccgnng angcngggcc nnnngcnngc cgnaannggc      600

ggccnngnnn ancnccgacg anccaanang gaannncngn nnaacaaaac gggcngggcg      660

nncgcggcac nnngcnnngn ccnggcnang acancaggac agangnggaa ccacanncga      720

ggnccgccnn acgcccanaa gaacccncan accggccacg nnaannacan ccangggnca      780

ncncaagccc aanncgnagc cgagacgcan anagnnnngn ngnncaacgg gggagnnaca      840

nngggcangg nccngcncng cgaagccgcg acnncngana nggacancgg gaaacgcaag      900

anaangngcg nagccgggan ngggnnggnc gnacnnnnnn ncagnnggan gnngnccanc      960

nnnaggagna aanaccacgg nnanccnnan ncannncnna ngncnnaa                  1008


<210>  19
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val Val 
1               5                   10                  15      


Ala Leu Leu Ile Val Cys Asp Val Pro Ser Ala Ser Ala Gln Arg Lys 
            20                  25                  30          


Lys Glu Met Val Leu Ser Glu Lys Val Ser Gln Leu Met Glu Trp Thr 
        35                  40                  45              


Asn Lys Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Arg Leu 
    50                  55                  60                  


Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 
65                  70                  75                  80  


Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 
                85                  90                  95      


Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr Asn 
            100                 105                 110         


Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 
        115                 120                 125             


Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro Ala 
    130                 135                 140                 


Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr Glu Leu Gln Val Arg Gly 
145                 150                 155                 160 


Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp Val 
                165                 170                 175     


Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu 
            180                 185                 190         


Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg Ser 
        195                 200                 205             


Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu 
    210                 215                 220                 


Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg 
225                 230                 235                 240 


Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr 
                245                 250                 255     


Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile Val 
            260                 265                 270         


Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 
        275                 280                 285             


Ala Ala Thr Ser Asp Met Asp Ile Gly Lys Arg Lys Ile Met Cys Val 
    290                 295                 300                 


Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser Ile 
305                 310                 315                 320 


Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 
                325                 330                 335 


<210>  20
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  p22phox coding sequence


<220>
<221>  misc_feature
<222>  (1)..(588)
<223>  n is pseudouridine

<400>  20
angggccaga ncgagngggc aangngggca aacgagcagg cccnggccnc cggccnganc       60

cngancacag gcggcancgn ggccaccgcc ggcagannca cccagnggna cnncggcgcc      120

nacnccancg nggccggcgn gnncgngngc cngcnggaan accccagagg caagcggaag      180

aaaggcagca ccanggaaag anggggccag aaacacanga ccgccgnggn gaaacngnnc      240

ggccccnnca cccggaacna cnacgngcgg gccgngcngc ancngcngcn gagcgngcca      300

gccggcnncc ngcnggccac aanccngggc accgccngcc nggccanngc cagcggcanc      360

nancngcngg cngccgngcg gggcgagcag nggacaccna ncgagcccaa gcccagagag      420

cggccccaga ncggcggcac cancaagcag ccccccagca acccnccacc cagaccncca      480

gccgaggccc ggaagaagcc nagcgaagaa gaagccgccg cngccgcngg aggaccnccn      540

ggcggaccac aggncaaccc canccccgng accgacgagg nggngnga                   588


<210>  21
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p22phox protein with A174V mutation

<400>  21

Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Gly Leu Ile Leu Ile Thr Gly Gly Ile Val Ala Thr Ala Gly Arg 
            20                  25                  30          


Phe Thr Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala Gly Val Phe 
        35                  40                  45              


Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys Gly Ser Thr 
    50                  55                  60                  


Met Glu Arg Trp Gly Gln Lys His Met Thr Ala Val Val Lys Leu Phe 
65                  70                  75                  80  


Gly Pro Phe Thr Arg Asn Tyr Tyr Val Arg Ala Val Leu His Leu Leu 
                85                  90                  95      


Leu Ser Val Pro Ala Gly Phe Leu Leu Ala Thr Ile Leu Gly Thr Ala 
            100                 105                 110         


Cys Leu Ala Ile Ala Ser Gly Ile Tyr Leu Leu Ala Ala Val Arg Gly 
        115                 120                 125             


Glu Gln Trp Thr Pro Ile Glu Pro Lys Pro Arg Glu Arg Pro Gln Ile 
    130                 135                 140                 


Gly Gly Thr Ile Lys Gln Pro Pro Ser Asn Pro Pro Pro Arg Pro Pro 
145                 150                 155                 160 


Ala Glu Ala Arg Lys Lys Pro Ser Glu Glu Glu Ala Ala Ala Ala Ala 
                165                 170                 175     


Gly Gly Pro Pro Gly Gly Pro Gln Val Asn Pro Ile Pro Val Thr Asp 
            180                 185                 190         


Glu Val Val 
        195 


<210>  22
<211>  1581
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  p67phox coding sequence


<220>
<221>  misc_feature
<222>  (1)..(1581)
<223>  n is pseudouridine

<400>  22
angagccngg nggaagccan cagccngngg aacgagggcg ngcnggccgc cgacaagaag       60

gacnggaaag gcgcccngga ngccnncagc gccgngcagg acccccacag ccggancngc      120

nncaacancg gcngcangna caccanccng aagaacanga ccgaggccga gaaggccnnc      180

acccggncca ncaaccggga caagcaccng gccgnggccn acnnccagcg gggcangcng      240

nacnaccaga ccgagaagna cgaccnggcc ancaaggacc ngaaagaggc ccnganccag      300

cngcggggca accagcngan cgacnacaag anccngggcc ngcagnncaa gcngnncgcc      360

ngcgaggngc ngnacaanan cgccnnnang nacgccaaga aagaggaang gaagaaggcc      420

gaggaacagc nggcncnggc caccagcang aagnccgagc cccggcacag caagancgac      480

aaggccangg aangcgngng gaagcagaaa cngnacgagc ccgnggngan ccccgngggc      540

aagcngnncc ggcccaacga gagacaggng gcccagcngg ccaagaagga nnaccngggc      600

aaggcnaccg nggnggccnc cgnggnggac caggacagcn ncagcggcnn cgccccncng      660

cagccncagg ccgccgaacc cccnccaaga cccaagaccc ccgagancnn ccgggcncng      720

gaaggcgagg cccaccgggn gcngnncggc nncgngcccg agacaaaaga ggaacngcag      780

gncangcccg gcaacancgn gnncgngcng aagaagggca acgacaacng ggccaccgng      840

angnncaacg gccagaaagg ccnggngccc ngcaacnacc nggaacccgn ggaacngcgg      900

anccaccccc agcagcagcc ccaggaagag agcagccccc agagcganan cccngccccc      960

ccnagcagca aggccccngg cagaccncag cngagcccag gccagaagca gaaagaagaa     1020

cccaaagaag ncaagcngag cgnccccang cccnacaccc ngaaggngca cnacaagnac     1080

accgnggnga ngaagaccca gcccggccng cccnacagcc aggnccgcga canggngncc     1140

aagaagcngg aacngagacn ggaacacacc aagcngagcn accggcccag agacagcaac     1200

gagcnggngc cccngagcga ggacagcang aaggacgccn ggggccaggn caaaaacnac     1260

ngccngaccc ngnggngcga gaacaccgng ggcgaccagg gcnnccccga cgagcccaaa     1320

gagagcgaga aggccgacgc caacaaccag accaccgagc cccagcngaa gaaaggcncc     1380

caggnggaag cccngnncag cnacgaggcc acccagcccg aggaccngga annncaggaa     1440

ggcgacanca nccnggngcn gagcaaagng aacgaggaan ggcnggaagg cgaangcaag     1500

ggcaaagngg gcancnnccc caaggngnnc gnggaagann gcgccaccac cgaccnggaa     1560

agcaccagac gggaagngng a                                               1581


<210>  23
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p67phox protein with H389Q mutation

<400>  23

Met Ser Leu Val Glu Ala Ile Ser Leu Trp Asn Glu Gly Val Leu Ala 
1               5                   10                  15      


Ala Asp Lys Lys Asp Trp Lys Gly Ala Leu Asp Ala Phe Ser Ala Val 
            20                  25                  30          


Gln Asp Pro His Ser Arg Ile Cys Phe Asn Ile Gly Cys Met Tyr Thr 
        35                  40                  45              


Ile Leu Lys Asn Met Thr Glu Ala Glu Lys Ala Phe Thr Arg Ser Ile 
    50                  55                  60                  


Asn Arg Asp Lys His Leu Ala Val Ala Tyr Phe Gln Arg Gly Met Leu 
65                  70                  75                  80  


Tyr Tyr Gln Thr Glu Lys Tyr Asp Leu Ala Ile Lys Asp Leu Lys Glu 
                85                  90                  95      


Ala Leu Ile Gln Leu Arg Gly Asn Gln Leu Ile Asp Tyr Lys Ile Leu 
            100                 105                 110         


Gly Leu Gln Phe Lys Leu Phe Ala Cys Glu Val Leu Tyr Asn Ile Ala 
        115                 120                 125             


Phe Met Tyr Ala Lys Lys Glu Glu Trp Lys Lys Ala Glu Glu Gln Leu 
    130                 135                 140                 


Ala Leu Ala Thr Ser Met Lys Ser Glu Pro Arg His Ser Lys Ile Asp 
145                 150                 155                 160 


Lys Ala Met Glu Cys Val Trp Lys Gln Lys Leu Tyr Glu Pro Val Val 
                165                 170                 175     


Ile Pro Val Gly Lys Leu Phe Arg Pro Asn Glu Arg Gln Val Ala Gln 
            180                 185                 190         


Leu Ala Lys Lys Asp Tyr Leu Gly Lys Ala Thr Val Val Ala Ser Val 
        195                 200                 205             


Val Asp Gln Asp Ser Phe Ser Gly Phe Ala Pro Leu Gln Pro Gln Ala 
    210                 215                 220                 


Ala Glu Pro Pro Pro Arg Pro Lys Thr Pro Glu Ile Phe Arg Ala Leu 
225                 230                 235                 240 


Glu Gly Glu Ala His Arg Val Leu Phe Gly Phe Val Pro Glu Thr Lys 
                245                 250                 255     


Glu Glu Leu Gln Val Met Pro Gly Asn Ile Val Phe Val Leu Lys Lys 
            260                 265                 270         


Gly Asn Asp Asn Trp Ala Thr Val Met Phe Asn Gly Gln Lys Gly Leu 
        275                 280                 285             


Val Pro Cys Asn Tyr Leu Glu Pro Val Glu Leu Arg Ile His Pro Gln 
    290                 295                 300                 


Gln Gln Pro Gln Glu Glu Ser Ser Pro Gln Ser Asp Ile Pro Ala Pro 
305                 310                 315                 320 


Pro Ser Ser Lys Ala Pro Gly Arg Pro Gln Leu Ser Pro Gly Gln Lys 
                325                 330                 335     


Gln Lys Glu Glu Pro Lys Glu Val Lys Leu Ser Val Pro Met Pro Tyr 
            340                 345                 350         


Thr Leu Lys Val His Tyr Lys Tyr Thr Val Val Met Lys Thr Gln Pro 
        355                 360                 365             


Gly Leu Pro Tyr Ser Gln Val Arg Asp Met Val Ser Lys Lys Leu Glu 
    370                 375                 380                 


Leu Arg Leu Glu His Thr Lys Leu Ser Tyr Arg Pro Arg Asp Ser Asn 
385                 390                 395                 400 


Glu Leu Val Pro Leu Ser Glu Asp Ser Met Lys Asp Ala Trp Gly Gln 
                405                 410                 415     


Val Lys Asn Tyr Cys Leu Thr Leu Trp Cys Glu Asn Thr Val Gly Asp 
            420                 425                 430         


Gln Gly Phe Pro Asp Glu Pro Lys Glu Ser Glu Lys Ala Asp Ala Asn 
        435                 440                 445             


Asn Gln Thr Thr Glu Pro Gln Leu Lys Lys Gly Ser Gln Val Glu Ala 
    450                 455                 460                 


Leu Phe Ser Tyr Glu Ala Thr Gln Pro Glu Asp Leu Glu Phe Gln Glu 
465                 470                 475                 480 


Gly Asp Ile Ile Leu Val Leu Ser Lys Val Asn Glu Glu Trp Leu Glu 
                485                 490                 495     


Gly Glu Cys Lys Gly Lys Val Gly Ile Phe Pro Lys Val Phe Val Glu 
            500                 505                 510         


Asp Cys Ala Thr Thr Asp Leu Glu Ser Thr Arg Arg Glu Val 
        515                 520                 525     


<210>  24
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  p40phox coding sequence


<220>
<221>  misc_feature
<222>  (1)..(1020)
<223>  n is pseudoruidine

<400>  24
anggccgnng cccagcagnn gcgcgccgaa agcgannncg aacaanngcc agacgangnc       60

gccancagng cnaacanngc ngananngaa gaaaagcgag gcnnnaccnc ncacnncgnn      120

nnngngancg aagnnaaaac naaaggagga agnaaanacc ncannnanag gaggnancga      180

caannncacg cccngcaanc aaagcncgaa gagaggnncg gnccngacag caagncanca      240

gcacnngcnn gcacgcngcc cacacnccca gcgaaggnnn acgnaggcgn aaaacaggaa      300

ancgcagaga ngagganncc ngcccngaan gcanananga aancccnncn cagccngccc      360

gnnngggnnn ngangganga agacgngagg ancnncnnnn accagagccc ananganncn      420

gaacaggncc cgcaggcgcn ncgccgacnn cgcccgcgca cacgaaaagn aaaanccgnc      480

agnccncagg ggaanncngn ggaccggang gcngcgccac gagcagaagc gcnnnnngan      540

nncacgggca acncaaagnn ggaacngaan nncaaggcng gcgacgngan annncngnng      600

agnagganca anaaaganng gcnngaagga accgngagag gagcnaccgg canannnccn      660

cnnnccnncg naaaganccn caaggacnnc ccagaggaag anganccaac naannggcnn      720

cgangnnann annacgaaga cacganancc acgancaaag ananagcagn ggaggaggac      780

nngagnncna caccacngnn gaaggannng cncgaacnca ccaggagaga gnnccaaagg      840

gaggananng cgnngaanna ccgcgacgcn gaaggagacc nggnccgacn gnngagcgac      900

gaggangncg cccnnanggn ncgccaggca agggggnngc ccagccaaaa acgccnnnnn      960

ccgnggaaac nccanancac acagaaagac aacnanaggg ncnacaacac aangcccnga     1020


<210>  25
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Val Ala Gln Gln Leu Arg Ala Glu Ser Asp Phe Glu Gln Leu 
1               5                   10                  15      


Pro Asp Asp Val Ala Ile Ser Ala Asn Ile Ala Asp Ile Glu Glu Lys 
            20                  25                  30          


Arg Gly Phe Thr Ser His Phe Val Phe Val Ile Glu Val Lys Thr Lys 
        35                  40                  45              


Gly Gly Ser Lys Tyr Leu Ile Tyr Arg Arg Tyr Arg Gln Phe His Ala 
    50                  55                  60                  


Leu Gln Ser Lys Leu Glu Glu Arg Phe Gly Pro Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Ala Leu Ala Cys Thr Leu Pro Thr Leu Pro Ala Lys Val Tyr Val Gly 
                85                  90                  95      


Val Lys Gln Glu Ile Ala Glu Met Arg Ile Pro Ala Leu Asn Ala Tyr 
            100                 105                 110         


Met Lys Ser Leu Leu Ser Leu Pro Val Trp Val Leu Met Asp Glu Asp 
        115                 120                 125             


Val Arg Ile Phe Phe Tyr Gln Ser Pro Tyr Asp Ser Glu Gln Val Pro 
    130                 135                 140                 


Gln Ala Leu Arg Arg Leu Arg Pro Arg Thr Arg Lys Val Lys Ser Val 
145                 150                 155                 160 


Ser Pro Gln Gly Asn Ser Val Asp Arg Met Ala Ala Pro Arg Ala Glu 
                165                 170                 175     


Ala Leu Phe Asp Phe Thr Gly Asn Ser Lys Leu Glu Leu Asn Phe Lys 
            180                 185                 190         


Ala Gly Asp Val Ile Phe Leu Leu Ser Arg Ile Asn Lys Asp Trp Leu 
        195                 200                 205             


Glu Gly Thr Val Arg Gly Ala Thr Gly Ile Phe Pro Leu Ser Phe Val 
    210                 215                 220                 


Lys Ile Leu Lys Asp Phe Pro Glu Glu Asp Asp Pro Thr Asn Trp Leu 
225                 230                 235                 240 


Arg Cys Tyr Tyr Tyr Glu Asp Thr Ile Ser Thr Ile Lys Asp Ile Ala 
                245                 250                 255     


Val Glu Glu Asp Leu Ser Ser Thr Pro Leu Leu Lys Asp Leu Leu Glu 
            260                 265                 270         


Leu Thr Arg Arg Glu Phe Gln Arg Glu Asp Ile Ala Leu Asn Tyr Arg 
        275                 280                 285             


Asp Ala Glu Gly Asp Leu Val Arg Leu Leu Ser Asp Glu Asp Val Ala 
    290                 295                 300                 


Leu Met Val Arg Gln Ala Arg Gly Leu Pro Ser Gln Lys Arg Leu Phe 
305                 310                 315                 320 


Pro Trp Lys Leu His Ile Thr Gln Lys Asp Asn Tyr Arg Val Tyr Asn 
                325                 330                 335     


Thr Met Pro 
            


<210>  26
<211>  2025
<212>  RNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (156)..(827)

<400>  26
cuucugugug ugcacaugug uaauacauau cugggaucaa agcuaucuau auaaaguccu       60

ugauucugug uggguucaaa cacauuucaa agcuucagga uccugaaagg uuuugcucua      120

cuuccugaag accugaacac cgcucccaua aagcc aug gcu ugc cuu gga uuu         173
                                       Met Ala Cys Leu Gly Phe            
                                       1               5                  

cag cgg cac aag gcu cag cug aac cug gcu acc agg acc ugg ccc ugc        221
Gln Arg His Lys Ala Gln Leu Asn Leu Ala Thr Arg Thr Trp Pro Cys           
            10                  15                  20                    

acu cuc cug uuu uuu cuu cuc uuc auc ccu guc uuc ugc aaa gca aug        269
Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro Val Phe Cys Lys Ala Met           
        25                  30                  35                        

cac gug gcc cag ccu gcu gug gua cug gcc agc agc cga ggc auc gcc        317
His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala           
    40                  45                  50                            

agc uuu gug ugu gag uau gca ucu cca ggc aaa gcc acu gag guc cgg        365
Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg           
55                  60                  65                  70            

gug aca gug cuu cgg cag gcu gac agc cag gug acu gaa guc ugu gcg        413
Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala           
                75                  80                  85                

gca acc uac aug aug ggg aau gag uug acc uuc cua gau gau ucc auc        461
Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile           
            90                  95                  100                   

ugc acg ggc acc ucc agu gga aau caa gug aac cuc acu auc caa gga        509
Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly           
        105                 110                 115                       

cug agg gcc aug gac acg gga cuc uac auc ugc aag gug gag cuc aug        557
Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met           
    120                 125                 130                           

uac cca ccg cca uac uac cug ggc aua ggc aac gga acc cag auu uau        605
Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr           
135                 140                 145                 150           

gua auu gau cca gaa ccg ugc cca gau ucu gac uuc cuc cuc ugg auc        653
Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu Leu Trp Ile           
                155                 160                 165               

cuu gca gca guu agu ucg ggg uug uuu uuu uau agc uuu cuc cuc aca        701
Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe Leu Leu Thr           
            170                 175                 180                   

gcu guu ucu uug agc aaa aug cua aag aaa aga agc ccu cuu aca aca        749
Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu Thr Thr           
        185                 190                 195                       

ggg guc uau gug aaa aug ccc cca aca gag cca gaa ugu gaa aag caa        797
Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys Glu Lys Gln           
    200                 205                 210                           

uuu cag ccu uau uuu auu ccc auc aau uga gaaaccauua ugaagaagag          847
Phe Gln Pro Tyr Phe Ile Pro Ile Asn                                       
215                 220                                                   

aguccauauu ucaauuucca agagcugagg caauucuaac uuuuuugcua uccagcuauu      907

uuuauuuguu ugugcauuug gggggaauuc aucucucuuu aauauaaagu uggaugcgga      967

acccaaauua cguguacuac aauuuaaagc aaaggaguag aaagacagag cugggauguu     1027

ucugucacau cagcuccacu uucagugaaa gcaucacuug ggauuaauau ggggaugcag     1087

cauuaugaug ugggucaagg aauuaaguua gggaauggca cagcccaaag aaggaaaagg     1147

cagggagcga gggagaagac uauauuguac acaccuuaua uuuacguaug agacguuuau     1207

agccgaaaug aucuuuucaa guuaaauuuu augccuuuua uuucuuaaac aaauguauga     1267

uuacaucaag gcuucaaaaa uacucacaug gcuauguuuu agccagugau gcuaaagguu     1327

guauugcaua uauacauaua uauauauaua uauauauaua uauauauaua uauauauaua     1387

uauuuuaauu ugauaguauu gugcauagag ccacguaugu uuuuguguau uuguuaaugg     1447

uuugaauaua aacacuauau ggcagugucu uuccaccuug ggucccaggg aaguuuugug     1507

gaggagcuca ggacacuaau acaccaggua gaacacaagg ucauuugcua acuagcuugg     1567

aaacuggaug aggucauagc agugcuugau ugcguggaau ugugcugagu ugguguugac     1627

augugcuuug gggcuuuuac accaguuccu uucaaugguu ugcaaggaag ccacagcugg     1687

ugguaucuga guugacuuga cagaacacug ucuugaagac aauggcuuac uccaggagac     1747

ccacagguau gaccuucuag gaagcuccag uucgaugggc ccaauucuua caaacaugug     1807

guuaaugcca uggacagaag aaggcagcag guggcagaau ggggugcaug aagguuucug     1867

aaaauuaaca cugcuugugu uuuuaacuca auauuuucca ugaaaaugca acaacaugua     1927

uaauauuuuu aauuaaauaa aaaucugugg uggucguuuu aaaaaaaaaa aaaaaaaaaa     1987

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             2025


<210>  27
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  28
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  28
acatttgctt ctgacacaac tgtgttcact agcaacctca tacagacacc                  50


<210>  29
<211>  69
<212>  DNA
<213>  Xenopus laevis

<400>  29
gaatacaagc ttcttgttct ttttgcagaa gctcagaata aacgctcaac tttggcagat       60

ctgaacatg                                                               69


<210>  30
<211>  135
<212>  DNA
<213>  Homo sapiens

<400>  30
taagctcgct ttcttgctgt ccaatttcta ttaaaggttc ctttgttccc taagtccaac       60

tactaaactg ggggatatta tgaagggcct tgagcatctg gattctgcct aataaaaaac      120

atttattttc attgc                                                       135


<210>  31
<211>  199
<212>  DNA
<213>  Xenopus laevis

<400>  31
gatctggtta ccactaaacc agcctcaaga acacccgaat ggagtctcta agctacataa       60

taccaactta cactttacaa aatgttgtcc cccaaaatgt agccattcgt atctgctcct      120

aataaaaaga aagtttcttc acattctaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

accccccccc ccccccccc                                                   199


<210>  32
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  consensus kozak sequence

<400>  32
gccgccrcca ugg                                                          13


