                         SEQUENCE LISTING

<110>  Academia Sinica
 
<120>  PARASPECKLE COMPONENT 1 (PSPC1) PROMOTING EPITHELIAL-MESENCHYMAL 
       TRANSITION, STEMNESS AND METASTASIS AS AN ANTI-CANCER TARGET

<130>  10011-075PCT

<150>  62631503
<151>  2018-02-16

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Asp Met Gly Pro Arg Gly Ala Ile Asn Met Gly Asp Ala Phe 
1               5                   10                  15      


Ser Pro Ala Pro Ala Gly Asn Gln Gly Pro Pro Pro Met Met Gly Met 
            20                  25                  30          


Asn Met Asn Asn Arg Ala Thr Ile Pro Gly Pro Pro Met Gly Pro Gly 
        35                  40                  45              


Pro Ala Met Gly Pro Glu Gly Ala Ala Asn Met Gly Thr Pro Met Met 
    50                  55                  60                  


Pro Asp Asn Gly Ala Val His Asn Asp Arg Phe Pro Gln Gly Pro Pro 
65                  70                  75                  80  


Ser Gln Met Gly Ser Pro Met Gly Ser Arg Thr Gly Ser Glu Thr Pro 
                85                  90                  95      


Gln Ala Pro Met Ser Gly Val Gly Pro Val Ser Gly Gly Pro Gly Gly 
            100                 105                 110         


Phe Gly Arg Gly Ser Gln Gly Gly Asn Phe Glu Gly Pro Asn Lys Arg 
        115                 120                 125             


Arg Arg Tyr 
    130     


<210>  2
<211>  2401
<212>  DNA
<213>  Homo sapiens

<400>  2
gagtgcgcag gcgcgtcgtt ccggcgccgg ctttggcgga ggggtgggac ttgcaccggc       60

gtctcttctt ctaactgcag tttgtggcag cgccattttg aatgtgcagc tgcagcgggc      120

gcctgtatcc ggtgtccgag gcgaactcag taagatgatg ttaagaggaa acctgaagca      180

agtgcgcatt gagaaaaacc cggcccgcct tcgcgccctg gagtccgcgg tgggcgagag      240

cgagccggcg gccgcggcag ccatggcgct cgctcttgcc ggggagccgg caccgcccgc      300

gcccgcgcct ccagaggacc acccggacga ggagatgggg ttcactatcg acatcaagag      360

tttcctcaag ccgggcgaga agacgtacac gcagcgctgc cgcctcttcg tgggaaatct      420

gcccaccgac atcacggagg aggacttcaa gaggctcttc gaacgctatg gcgagcccag      480

cgaagtcttc atcaaccggg accgtggctt cggcttcatc cgcttggaat ccagaaccct      540

ggctgaaatt gcaaaagcag agctggacgg caccattctc aagagcagac ctctacggat      600

tcgcttcgct acacatggag cagccttgac tgtcaagaac ctttctccag ttgtttccaa      660

tgagctgcta gagcaagcat tttctcagtt tggtccagta gagaaagctg ttgtggttgt      720

ggatgatcgc ggtagagcta caggaaaagg ttttgtagag tttgcagcaa aacctcctgc      780

acgaaaggct ctggaaagat gtggtgatgg ggcattcttg ctaacaacga cccctcgtcc      840

agtcattgtg gaacccatgg agcagtttga tgatgaagat ggcttgccag agaagctgat      900

gcagaaaact caacaatatc ataaggaaag agaacaacca ccacgttttg ctcaacctgg      960

gacatttgaa tttgagtatg catctcgatg gaaggctctt gatgaaatgg aaaagcagca     1020

gcgtgagcag gttgatagaa acatcagaga agccaaagag aaactggagg cagaaatgga     1080

agcagctagg catgaacacc aattaatgct aatgaggcaa gatctaatga ggcgtcaaga     1140

agaactcaga cgcttggaag aactcagaaa ccaagagttg caaaaacgga agcaaataca     1200

actaagacat gaagaggagc atcggcggcg tgaggaagaa atgatccgac acagagaaca     1260

ggaggaactg aggcgacagc aagagggctt taagccaaac tacatggaaa atagagaaca     1320

ggaaatgaga atgggtgata tgggtccccg tggagcaata aacatgggag atgcgtttag     1380

cccagcccct gctggtaacc aaggtcctcc tccaatgatg ggtatgaata tgaacaacag     1440

agcaactata cctggcccac caatgggtcc tggtcctgcc atgggaccag aaggagccgc     1500

aaatatggga actccaatga tgccagataa tggagcagtg cacaatgaca gatttcctca     1560

aggaccacca tctcagatgg gttcacctat ggggagtaga acaggttctg aaacccctca     1620

agcaccaatg agtggtgtag gtcctgtgag tggtggtcct ggtggctttg gtagaggaag     1680

tcaagggggc aactttgaag gccctaataa gcgtcgtaga tattaaacat tcgttcattc     1740

ctggctatct agaaaaaaaa aagtcagtgg tatgccttta tacttttacc tgttatctgg     1800

aagaaatggt tttattgtta atgtatgtag acttaaaagt tttttttttt ttgtaaaact     1860

tgaggttttt gtatttttct ttattcatga gctttgtaga ttagaatggt aatgatgctc     1920

atcattttga atgttgaaat gtgtttgtga ctttagctaa atataagtat tccatagtac     1980

tgtgaaatct atgtagttaa tctcaataaa gaaatcattt tggataattt aaaactgtta     2040

ttagtggtat tctcttacgg tcttactaaa ctttgctgta acagtaatgc tttggttgct     2100

ttaactaatc ctatcattaa aaatgaaaat gattttgctt tttaatttgc gcaagtagca     2160

ctaaagatag aagcttaatt aatgaaagct aatgtcaata aggggtagat agagtagtat     2220

atgtgggggt gggagggtat gggagtttaa tttgtataaa ccactgatgt tctgtgaaat     2280

cggaatttcc agctacattt catatagctt ctgaatattc aggtattctg agacagatta     2340

ttaaggatat ctttgtcctg tgctgatttt tccaaataaa tctttttcat cttgaaaaaa     2400

a                                                                     2401


<210>  3
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Met Leu Arg Gly Asn Leu Lys Gln Val Arg Ile Glu Lys Asn Pro 
1               5                   10                  15      


Ala Arg Leu Arg Ala Leu Glu Ser Ala Val Gly Glu Ser Glu Pro Ala 
            20                  25                  30          


Ala Ala Ala Ala Met Ala Leu Ala Leu Ala Gly Glu Pro Ala Pro Pro 
        35                  40                  45              


Ala Pro Ala Pro Pro Glu Asp His Pro Asp Glu Glu Met Gly Phe Thr 
    50                  55                  60                  


Ile Asp Ile Lys Ser Phe Leu Lys Pro Gly Glu Lys Thr Tyr Thr Gln 
65                  70                  75                  80  


Arg Cys Arg Leu Phe Val Gly Asn Leu Pro Thr Asp Ile Thr Glu Glu 
                85                  90                  95      


Asp Phe Lys Arg Leu Phe Glu Arg Tyr Gly Glu Pro Ser Glu Val Phe 
            100                 105                 110         


Ile Asn Arg Asp Arg Gly Phe Gly Phe Ile Arg Leu Glu Ser Arg Thr 
        115                 120                 125             


Leu Ala Glu Ile Ala Lys Ala Glu Leu Asp Gly Thr Ile Leu Lys Ser 
    130                 135                 140                 


Arg Pro Leu Arg Ile Arg Phe Ala Thr His Gly Ala Ala Leu Thr Val 
145                 150                 155                 160 


Lys Asn Leu Ser Pro Val Val Ser Asn Glu Leu Leu Glu Gln Ala Phe 
                165                 170                 175     


Ser Gln Phe Gly Pro Val Glu Lys Ala Val Val Val Val Asp Asp Arg 
            180                 185                 190         


Gly Arg Ala Thr Gly Lys Gly Phe Val Glu Phe Ala Ala Lys Pro Pro 
        195                 200                 205             


Ala Arg Lys Ala Leu Glu Arg Cys Gly Asp Gly Ala Phe Leu Leu Thr 
    210                 215                 220                 


Thr Thr Pro Arg Pro Val Ile Val Glu Pro Met Glu Gln Phe Asp Asp 
225                 230                 235                 240 


Glu Asp Gly Leu Pro Glu Lys Leu Met Gln Lys Thr Gln Gln Tyr His 
                245                 250                 255     


Lys Glu Arg Glu Gln Pro Pro Arg Phe Ala Gln Pro Gly Thr Phe Glu 
            260                 265                 270         


Phe Glu Tyr Ala Ser Arg Trp Lys Ala Leu Asp Glu Met Glu Lys Gln 
        275                 280                 285             


Gln Arg Glu Gln Val Asp Arg Asn Ile Arg Glu Ala Lys Glu Lys Leu 
    290                 295                 300                 


Glu Ala Glu Met Glu Ala Ala Arg His Glu His Gln Leu Met Leu Met 
305                 310                 315                 320 


Arg Gln Asp Leu Met Arg Arg Gln Glu Glu Leu Arg Arg Leu Glu Glu 
                325                 330                 335     


Leu Arg Asn Gln Glu Leu Gln Lys Arg Lys Gln Ile Gln Leu Arg His 
            340                 345                 350         


Glu Glu Glu His Arg Arg Arg Glu Glu Glu Met Ile Arg His Arg Glu 
        355                 360                 365             


Gln Glu Glu Leu Arg Arg Gln Gln Glu Gly Phe Lys Pro Asn Tyr Met 
    370                 375                 380                 


Glu Asn Arg Glu Gln Glu Met Arg Met Gly Asp Met Gly Pro Arg Gly 
385                 390                 395                 400 


Ala Ile Asn Met Gly Asp Ala Phe Ser Pro Ala Pro Ala Gly Asn Gln 
                405                 410                 415     


Gly Pro Pro Pro Met Met Gly Met Asn Met Asn Asn Arg Ala Thr Ile 
            420                 425                 430         


Pro Gly Pro Pro Met Gly Pro Gly Pro Ala Met Gly Pro Glu Gly Ala 
        435                 440                 445             


Ala Asn Met Gly Thr Pro Met Met Pro Asp Asn Gly Ala Val His Asn 
    450                 455                 460                 


Asp Arg Phe Pro Gln Gly Pro Pro Ser Gln Met Gly Ser Pro Met Gly 
465                 470                 475                 480 


Ser Arg Thr Gly Ser Glu Thr Pro Gln Ala Pro Met Ser Gly Val Gly 
                485                 490                 495     


Pro Val Ser Gly Gly Pro Gly Gly Phe Gly Arg Gly Ser Gln Gly Gly 
            500                 505                 510         


Asn Phe Glu Gly Pro Asn Lys Arg Arg Arg Tyr 
        515                 520             


<210>  4
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Ser Arg Asp Gln Ala His Leu Gly Pro Lys Tyr Val Gly Leu 
1               5                   10                  15      


Trp Asp Phe Lys Ser Arg Thr Asp Glu Glu Leu Ser Phe Arg Ala Gly 
            20                  25                  30          


Asp Val Phe His Val Ala Arg Lys Glu Glu Gln Trp Trp Trp Ala Thr 
        35                  40                  45              


Leu Leu Asp Glu Ala Gly Gly Ala Val Ala Gln Gly Tyr Val Pro His 
    50                  55                  60                  


Asn Tyr Leu Ala Glu Arg Glu Thr Val Glu Ser Glu Pro Trp Phe Phe 
65                  70                  75                  80  


Gly Cys Ile Ser Arg Ser Glu Ala Val Arg Arg Leu Gln Ala Glu Gly 
                85                  90                  95      


Asn Ala Thr Gly Ala Phe Leu Ile Arg Val Ser Glu Lys Pro Ser Ala 
            100                 105                 110         


Asp Tyr Val Leu Ser Val Arg Asp Thr Gln Ala Val Arg His Tyr Lys 
        115                 120                 125             


Ile Trp Arg Arg Ala Gly Gly Arg Leu His Leu Asn Glu Ala Val Ser 
    130                 135                 140                 


Phe Leu Ser Leu Pro Glu Leu Val Asn Tyr His Arg Ala Gln Ser Leu 
145                 150                 155                 160 


Ser His Gly Leu Arg Leu Ala Ala Pro Cys Arg Lys His Glu Pro Glu 
                165                 170                 175     


Pro Leu Pro His Trp Asp Asp Trp Glu Arg Pro Arg Glu Glu Phe Thr 
            180                 185                 190         


Leu Cys Arg Lys Leu Gly Ser Gly Tyr Phe Gly Glu Val Phe Glu Gly 
        195                 200                 205             


Leu Trp Lys Asp Arg Val Gln Val Ala Ile Lys Val Ile Ser Arg Asp 
    210                 215                 220                 


Asn Leu Leu His Gln Gln Met Leu Gln Ser Glu Ile Gln Ala Met Lys 
225                 230                 235                 240 


Lys Leu Arg His Lys His Ile Leu Ala Leu Tyr Ala Val Val Ser Val 
                245                 250                 255     


Gly Asp Pro Val Tyr Ile Ile Thr Glu Leu Met Ala Lys Gly Ser Leu 
            260                 265                 270         


Leu Glu Leu Leu Arg Asp Ser Asp Glu Lys Val Leu Pro Val Ser Glu 
        275                 280                 285             


Leu Leu Asp Ile Ala Trp Gln Val Ala Glu Gly Met Cys Tyr Leu Glu 
    290                 295                 300                 


Ser Gln Asn Tyr Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
305                 310                 315                 320 


Gly Glu Asn Thr Leu Cys Lys Val Gly Asp Phe Gly Leu Ala Arg Leu 
                325                 330                 335     


Ile Lys Glu Asp Val Tyr Leu Ser His Asp His Asn Ile Pro Tyr Lys 
            340                 345                 350         


Trp Thr Ala Pro Glu Ala Leu Ser Arg Gly His Tyr Ser Thr Lys Ser 
        355                 360                 365             


Asp Val Trp Ser Phe Gly Ile Leu Leu His Glu Met Phe Ser Arg Gly 
    370                 375                 380                 


Gln Val Pro Tyr Pro Gly Met Ser Asn His Glu Ala Phe Leu Arg Val 
385                 390                 395                 400 


Asp Ala Gly Tyr Arg Met Pro Cys Pro Leu Glu Cys Pro Pro Ser Val 
                405                 410                 415     


His Lys Leu Met Leu Thr Cys Trp Cys Arg Asp Pro Glu Gln Arg Pro 
            420                 425                 430         


Cys Phe Lys Ala Leu Arg Glu Arg Leu Ser Ser Phe Thr Ser Tyr Glu 
        435                 440                 445             


Asn Pro Thr 
    450     


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  phosphopeptide amino acid sequence with Y phosphorylated

<400>  5

Cys Gly Gly Asn Phe Glu Gly Pro Asn Lys Arg Arg Arg Tyr 
1               5                   10                  


<210>  6
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y523F-F

<400>  6
ccctaataag cgtcgtagat tttaatctag agggccctat tc                          42


<210>  7
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y523F-R

<400>  7
gaataggccc tctagattaa aatctacgac gcttattagg g                           41


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal 511-523 of PSPC1

<400>  8

Gly Gly Asn Phe Glu Gly Pro Asn Lys Arg Arg Arg Tyr 
1               5                   10              


